locus-tag	class	description
LDO21_RS00020	COG1414	Transcriptional regulator
LDO21_RS00025	COG0154	amidase activity
LDO21_RS00040	COG1304	FMN binding
LDO21_RS00100	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LDO21_RS00115	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LDO21_RS00120	COG3181	Tripartite tricarboxylate transporter family receptor
LDO21_RS00130	COG2358	TRAP transporter, solute receptor (TAXI family
LDO21_RS00140	COG1629	transport
LDO21_RS00145	COG2922	Belongs to the Smg family
LDO21_RS00170	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LDO21_RS00175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LDO21_RS00180	COG1028	Short-chain dehydrogenase reductase Sdr
LDO21_RS00185	COG1012	belongs to the aldehyde dehydrogenase family
LDO21_RS00195	COG0028	Belongs to the TPP enzyme family
LDO21_RS00200	COG1522	sequence-specific DNA binding
LDO21_RS00205	COG3781	membrane
LDO21_RS00215	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LDO21_RS00235	COG4206	TonB-dependent receptor
LDO21_RS00240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LDO21_RS00245	COG2022	thiamine diphosphate biosynthetic process
LDO21_RS00250	COG0351	phosphomethylpyrimidine kinase
LDO21_RS00255	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LDO21_RS00265	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LDO21_RS00275	COG0628	permease
LDO21_RS00285	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LDO21_RS00295	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LDO21_RS00300	COG0049	tRNA binding
LDO21_RS00305	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LDO21_RS00310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LDO21_RS00315	COG0051	transcription antitermination factor activity, RNA binding
LDO21_RS00320	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LDO21_RS00325	COG0088	Forms part of the polypeptide exit tunnel
LDO21_RS00330	COG0089	rRNA binding
LDO21_RS00335	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LDO21_RS00340	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LDO21_RS00345	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LDO21_RS00350	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LDO21_RS00355	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LDO21_RS00360	COG0255	Belongs to the universal ribosomal protein uL29 family
LDO21_RS00365	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LDO21_RS00385	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LDO21_RS00390	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LDO21_RS00395	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LDO21_RS00400	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LDO21_RS00405	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LDO21_RS00410	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LDO21_RS00415	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LDO21_RS00420	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LDO21_RS00425	COG1841	ribosomal large subunit assembly
LDO21_RS00430	COG0200	Binds to the 23S rRNA
LDO21_RS00435	COG0201	protein transport
LDO21_RS00440	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LDO21_RS00445	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LDO21_RS00450	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LDO21_RS00455	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LDO21_RS00460	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LDO21_RS00465	COG0202	RNA polymerase activity
LDO21_RS00470	COG0203	ribosomal protein L17
LDO21_RS00475	COG0537	adenosine 5'-monophosphoramidase activity
LDO21_RS00480	COG1324	tolerance protein
LDO21_RS00485	COG4232	protein-disulfide reductase activity
LDO21_RS00500	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LDO21_RS00510	COG1333	cytochrome c biogenesis protein
LDO21_RS00515	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LDO21_RS00530	COG1965	Belongs to the frataxin family
LDO21_RS00540	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LDO21_RS00545	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LDO21_RS00550	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LDO21_RS00565	COG2814	Major facilitator Superfamily
LDO21_RS00570	COG0629	single-stranded DNA binding
LDO21_RS00610	COG0402	S-adenosylhomocysteine deaminase activity
LDO21_RS00620	COG0438	transferase activity, transferring glycosyl groups
LDO21_RS00640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LDO21_RS00660	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LDO21_RS00685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LDO21_RS00690	COG1956	GAF domain-containing protein
LDO21_RS00695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LDO21_RS00705	COG1652	LysM domain
LDO21_RS00720	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LDO21_RS00735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LDO21_RS00765	COG3181	Tripartite tricarboxylate transporter family receptor
LDO21_RS00780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LDO21_RS00795	COG1024	Enoyl-CoA hydratase
LDO21_RS00810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDO21_RS00815	COG1309	transcriptional regulator
LDO21_RS00820	COG2816	NAD+ diphosphatase activity
LDO21_RS00825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LDO21_RS00910	COG2814	Major facilitator Superfamily
LDO21_RS00915	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LDO21_RS00935	COG1999	signal sequence binding
LDO21_RS00940	COG0109	protoheme IX farnesyltransferase activity
LDO21_RS00980	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LDO21_RS01000	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LDO21_RS01005	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LDO21_RS01015	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LDO21_RS01020	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LDO21_RS01030	COG0067	glutamate synthase
LDO21_RS01030	COG0069	glutamate synthase activity
LDO21_RS01030	COG0070	glutamate synthase
LDO21_RS01040	COG3047	cAMP biosynthetic process
LDO21_RS01050	COG1127	ABC transporter
LDO21_RS01055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LDO21_RS01060	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LDO21_RS01065	COG2853	Lipoprotein
LDO21_RS01080	COG0842	Transport permease protein
LDO21_RS01090	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LDO21_RS01095	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LDO21_RS01100	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LDO21_RS01105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LDO21_RS01110	COG0131	Imidazoleglycerol-phosphate dehydratase
LDO21_RS01115	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LDO21_RS01120	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LDO21_RS01125	COG0107	imidazoleglycerol-phosphate synthase activity
LDO21_RS01130	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LDO21_RS01135	COG0140	phosphoribosyl-ATP diphosphatase activity
LDO21_RS01140	COG0537	adenosine 5'-monophosphoramidase activity
LDO21_RS01145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LDO21_RS01150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LDO21_RS01175	COG3181	Tripartite tricarboxylate transporter family receptor
LDO21_RS01210	COG3702	type iv secretory pathway
LDO21_RS01215	COG3451	type IV secretory pathway VirB4
LDO21_RS01230	COG3736	Type IV secretory pathway, component VirB8
LDO21_RS01235	COG3504	Conjugal transfer protein
LDO21_RS01240	COG2948	multi-organism process
LDO21_RS01245	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
LDO21_RS01255	COG0697	spore germination
LDO21_RS01275	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LDO21_RS01280	COG0747	negative chemotaxis
LDO21_RS01285	COG0601	transmembrane transport
LDO21_RS01290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDO21_RS01305	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LDO21_RS01315	COG0494	nUDIX hydrolase
LDO21_RS01350	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
LDO21_RS01355	COG0237	dephospho-CoA kinase activity
LDO21_RS01360	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LDO21_RS01375	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LDO21_RS01380	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LDO21_RS01390	COG0477	Major facilitator Superfamily
LDO21_RS01395	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LDO21_RS01410	COG1126	abc transporter atp-binding protein
LDO21_RS01415	COG0765	amino acid transport
LDO21_RS01420	COG4597	amino acid ABC transporter
LDO21_RS01425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDO21_RS01430	COG2884	Cell division ATP-binding protein ftsE
LDO21_RS01435	COG2177	Part of the ABC transporter FtsEX involved in
LDO21_RS01440	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
LDO21_RS01455	COG1194	a g-specific adenine glycosylase
LDO21_RS01465	COG2226	methyltransferase
LDO21_RS01480	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDO21_RS01485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDO21_RS01500	COG1024	Enoyl-CoA hydratase
LDO21_RS01520	COG1024	Enoyl-CoA hydratase
LDO21_RS01525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDO21_RS01530	COG3181	Tripartite tricarboxylate transporter family receptor
LDO21_RS01540	COG0753	catalase activity
LDO21_RS01545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LDO21_RS01550	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LDO21_RS01560	COG2175	clavaminate synthase activity
LDO21_RS01565	COG1473	amidohydrolase
LDO21_RS01570	COG4608	Belongs to the ABC transporter superfamily
LDO21_RS01575	COG0444	Belongs to the ABC transporter superfamily
LDO21_RS01590	COG0747	negative chemotaxis
LDO21_RS01595	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LDO21_RS01630	COG0436	Aminotransferase
LDO21_RS01635	COG1278	Cold shock
LDO21_RS01640	COG0445	tRNA wobble uridine modification
LDO21_RS01645	COG0357	Ribosomal RNA small subunit methyltransferase G
LDO21_RS01650	COG1192	Involved in chromosome partitioning
LDO21_RS01660	COG1475	DNA binding
LDO21_RS01685	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LDO21_RS01695	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LDO21_RS01705	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LDO21_RS01710	COG0081	regulation of translation
LDO21_RS01715	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LDO21_RS01720	COG0222	ribosome binding
LDO21_RS01725	COG0085	RNA polymerase activity
LDO21_RS01730	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LDO21_RS01795	COG1024	Enoyl-CoA hydratase
LDO21_RS01825	COG0752	glycyl-tRNA synthetase alpha subunit
LDO21_RS01830	COG0751	glycine-tRNA ligase activity
LDO21_RS01835	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LDO21_RS01840	COG0204	Acyl-transferase
LDO21_RS01855	COG0242	peptide deformylase activity
LDO21_RS01895	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LDO21_RS01900	COG2813	Specifically methylates the guanine in position
LDO21_RS01900	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LDO21_RS01910	COG2223	nitrite transmembrane transporter activity
LDO21_RS01920	COG1794	racemase activity, acting on amino acids and derivatives
LDO21_RS01925	COG1126	abc transporter atp-binding protein
LDO21_RS01930	COG0765	amino acid transport
LDO21_RS01935	COG0765	amino acid transport
LDO21_RS02005	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LDO21_RS02035	COG0326	Molecular chaperone. Has ATPase activity
LDO21_RS02040	COG0625	glutathione transferase activity
LDO21_RS02055	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LDO21_RS02060	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LDO21_RS02095	COG0438	transferase activity, transferring glycosyl groups
LDO21_RS02100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LDO21_RS02105	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LDO21_RS02135	COG0859	PFAM glycosyl transferase family 9
LDO21_RS02150	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LDO21_RS02160	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LDO21_RS02165	COG1127	ABC transporter
LDO21_RS02185	COG1686	Belongs to the peptidase S11 family
LDO21_RS02195	COG2921	Belongs to the UPF0250 family
LDO21_RS02200	COG0321	lipoyl(octanoyl) transferase activity
LDO21_RS02205	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LDO21_RS02240	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LDO21_RS02250	COG0018	arginyl-trna synthetase
LDO21_RS02270	COG0395	ABC-type sugar transport system, permease component
LDO21_RS02275	COG1175	transmembrane transport
LDO21_RS02280	COG1653	transport
LDO21_RS02285	COG3842	ATPase activity
LDO21_RS02290	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LDO21_RS02300	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LDO21_RS02320	COG1609	Transcriptional regulator
LDO21_RS02330	COG0154	amidase activity
LDO21_RS02335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LDO21_RS02345	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LDO21_RS02355	COG0583	DNA-binding transcription factor activity
LDO21_RS02375	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LDO21_RS02390	COG1802	Transcriptional regulator
LDO21_RS02405	COG1024	Enoyl-CoA hydratase
LDO21_RS02415	COG3181	Tripartite tricarboxylate transporter family receptor
LDO21_RS02430	COG1984	allophanate hydrolase subunit 2
LDO21_RS02435	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LDO21_RS02445	COG0583	DNA-binding transcription factor activity
LDO21_RS02450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LDO21_RS02460	COG5002	protein histidine kinase activity
LDO21_RS02470	COG5002	protein histidine kinase activity
LDO21_RS02475	COG0745	RESPONSE REGULATOR receiver
LDO21_RS02480	COG2226	methyltransferase
LDO21_RS02495	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LDO21_RS02515	COG4608	Belongs to the ABC transporter superfamily
LDO21_RS02520	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
LDO21_RS02530	COG0513	Belongs to the DEAD box helicase family
LDO21_RS02535	COG1280	lysine exporter protein (LysE YggA)
LDO21_RS02540	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LDO21_RS02580	COG1054	Belongs to the UPF0176 family
LDO21_RS02585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LDO21_RS02585	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LDO21_RS02595	COG0489	protein tyrosine kinase activity
LDO21_RS02610	COG0717	Belongs to the dCTP deaminase family
LDO21_RS02640	COG2081	HI0933 family
LDO21_RS02650	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LDO21_RS02660	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LDO21_RS02665	COG0509	glycine decarboxylation via glycine cleavage system
LDO21_RS02670	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LDO21_RS02670	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LDO21_RS02710	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LDO21_RS02725	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LDO21_RS02735	COG1414	Transcriptional regulator
LDO21_RS02740	COG1028	Short-chain dehydrogenase reductase Sdr
LDO21_RS02745	COG2031	fatty acid transporter
LDO21_RS02750	COG1250	3-hydroxyacyl-CoA dehydrogenase
LDO21_RS02760	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LDO21_RS02765	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LDO21_RS02775	COG4257	antibiotic catabolic process
LDO21_RS02795	COG1012	belongs to the aldehyde dehydrogenase family
LDO21_RS02800	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LDO21_RS02805	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LDO21_RS02830	COG1028	Short-chain dehydrogenase reductase Sdr
LDO21_RS02840	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LDO21_RS02850	COG2188	Transcriptional regulator
LDO21_RS02855	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LDO21_RS02880	COG0617	tRNA 3'-terminal CCA addition
LDO21_RS02895	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LDO21_RS02900	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LDO21_RS02905	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LDO21_RS02910	COG0586	Pfam SNARE associated Golgi protein
LDO21_RS02915	COG0860	N-Acetylmuramoyl-L-alanine amidase
LDO21_RS02920	COG0802	atpase or kinase
LDO21_RS02925	COG0114	fumarate hydratase activity
LDO21_RS02935	COG3181	Tripartite tricarboxylate transporter family receptor
LDO21_RS02945	COG0405	Gamma-glutamyltransferase
LDO21_RS02950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDO21_RS02985	COG1294	oxidase, subunit
LDO21_RS02995	COG4988	ABC transporter
LDO21_RS03000	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LDO21_RS03005	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LDO21_RS03045	COG2969	positive regulation of protein catabolic process
LDO21_RS03050	COG0625	glutathione transferase activity
LDO21_RS03055	COG2857	Cytochrome c1
LDO21_RS03060	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LDO21_RS03065	COG0723	plastoquinol--plastocyanin reductase activity
LDO21_RS03070	COG1970	mechanosensitive ion channel activity
LDO21_RS03075	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LDO21_RS03090	COG2808	Putative FMN-binding domain
LDO21_RS03095	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LDO21_RS03100	COG0747	negative chemotaxis
LDO21_RS03105	COG0657	acetylesterase activity
LDO21_RS03115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LDO21_RS03120	COG2207	Transcriptional regulator
LDO21_RS03125	COG0129	dihydroxy-acid dehydratase activity
LDO21_RS03130	COG2814	Major facilitator Superfamily
LDO21_RS03135	COG0583	DNA-binding transcription factor activity
LDO21_RS03145	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
LDO21_RS03215	COG1024	Enoyl-CoA hydratase
LDO21_RS03220	COG1960	acyl-CoA dehydrogenase activity
LDO21_RS03245	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LDO21_RS03250	COG0352	thiamine-phosphate diphosphorylase activity
LDO21_RS03265	COG1678	Uncharacterized ACR, COG1678
LDO21_RS03270	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LDO21_RS03275	COG0540	Belongs to the ATCase OTCase family
LDO21_RS03290	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LDO21_RS03300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LDO21_RS03335	COG1234	tRNA 3'-trailer cleavage
LDO21_RS03355	COG3064	Membrane
LDO21_RS03385	COG1683	Conserved Protein
LDO21_RS03390	COG1120	ATPase activity
LDO21_RS03395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LDO21_RS03400	COG4558	Periplasmic binding protein
LDO21_RS03405	COG3720	iron ion transport
LDO21_RS03415	COG3712	iron ion homeostasis
LDO21_RS03420	COG1595	DNA-templated transcription, initiation
LDO21_RS03455	COG1802	Transcriptional regulator
LDO21_RS03465	COG3069	C4-dicarboxylate transmembrane transporter activity
LDO21_RS03475	COG1012	belongs to the aldehyde dehydrogenase family
LDO21_RS03510	COG2860	membrane
LDO21_RS03515	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LDO21_RS03520	COG0708	Exodeoxyribonuclease III
LDO21_RS03525	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LDO21_RS03530	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LDO21_RS03535	COG0154	amidase activity
LDO21_RS03540	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LDO21_RS03545	COG1077	Cell shape determining protein MreB Mrl
LDO21_RS03550	COG1792	Involved in formation and maintenance of cell shape
LDO21_RS03560	COG0768	penicillin binding
LDO21_RS03565	COG0772	Belongs to the SEDS family
LDO21_RS03570	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
LDO21_RS03575	COG0471	metal ion transport
LDO21_RS03580	COG1309	transcriptional regulator
LDO21_RS03590	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LDO21_RS03605	COG2823	Periplasmic or secreted lipoprotein
LDO21_RS03610	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LDO21_RS03625	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LDO21_RS03645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDO21_RS03655	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDO21_RS03680	COG0492	ferredoxin-NADP+ reductase activity
LDO21_RS03690	COG3181	Tripartite tricarboxylate transporter family receptor
LDO21_RS03695	COG1250	3-hydroxyacyl-CoA dehydrogenase
LDO21_RS03695	COG1024	Enoyl-CoA hydratase
LDO21_RS03700	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDO21_RS03705	COG0028	Belongs to the TPP enzyme family
LDO21_RS03730	COG3181	Tripartite tricarboxylate transporter family receptor
LDO21_RS03770	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LDO21_RS03775	COG0463	Glycosyl transferase, family 2
LDO21_RS03790	COG0786	glutamate:sodium symporter activity
LDO21_RS03800	COG2031	fatty acid transporter
LDO21_RS03815	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LDO21_RS03845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LDO21_RS03855	COG1285	pathogenesis
LDO21_RS03860	COG1253	flavin adenine dinucleotide binding
LDO21_RS03865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDO21_RS03870	COG1024	Enoyl-CoA hydratase
LDO21_RS03875	COG3181	Tripartite tricarboxylate transporter family receptor
LDO21_RS03880	COG0583	DNA-binding transcription factor activity
LDO21_RS03885	COG1960	acyl-CoA dehydrogenase activity
LDO21_RS03895	COG0183	Belongs to the thiolase family
LDO21_RS03920	COG0583	DNA-binding transcription factor activity
LDO21_RS03925	COG1278	Cold shock
LDO21_RS03940	COG1012	belongs to the aldehyde dehydrogenase family
LDO21_RS03945	COG2031	fatty acid transporter
LDO21_RS03950	COG1017	nitric oxide dioxygenase activity
LDO21_RS03950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LDO21_RS03955	COG0251	oxidation-reduction process
LDO21_RS03970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDO21_RS03980	COG0583	DNA-binding transcription factor activity
LDO21_RS03985	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDO21_RS03995	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
LDO21_RS04000	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LDO21_RS04005	COG0546	phosphoglycolate phosphatase activity
LDO21_RS04015	COG1530	ribonuclease E activity
LDO21_RS04035	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LDO21_RS04040	COG0159	tryptophan synthase activity
LDO21_RS04045	COG0133	tryptophan synthase activity
LDO21_RS04055	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LDO21_RS04060	COG3228	Belongs to the MtfA family
LDO21_RS04070	COG0251	oxidation-reduction process
LDO21_RS04075	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LDO21_RS04080	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LDO21_RS04095	COG2878	Part of a membrane complex involved in electron transport
LDO21_RS04100	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LDO21_RS04135	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LDO21_RS04155	COG1268	BioY protein
LDO21_RS04160	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LDO21_RS04165	COG1122	ATPase activity
LDO21_RS04170	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LDO21_RS04185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LDO21_RS04190	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LDO21_RS04200	COG1196	nuclear chromosome segregation
LDO21_RS04205	COG0477	Major facilitator Superfamily
LDO21_RS04210	COG1573	uracil-dna glycosylase
LDO21_RS04215	COG1214	PFAM Peptidase M22, glycoprotease
LDO21_RS04235	COG0450	alkyl hydroperoxide reductase
LDO21_RS04240	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LDO21_RS04250	COG2223	nitrite transmembrane transporter activity
LDO21_RS04260	COG2186	Transcriptional regulator
LDO21_RS04280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LDO21_RS04290	COG0583	DNA-binding transcription factor activity
LDO21_RS04300	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LDO21_RS04305	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LDO21_RS04310	COG0137	argininosuccinate synthase activity
LDO21_RS04315	COG3158	transport of potassium into the cell
LDO21_RS04320	COG0642	Histidine kinase
LDO21_RS04350	COG0776	regulation of translation
LDO21_RS04355	COG3128	pkhd-type hydroxylase
LDO21_RS04365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LDO21_RS04370	COG0557	exoribonuclease II activity
LDO21_RS04395	COG0679	Auxin Efflux Carrier
LDO21_RS04400	COG2391	methyltransferase activity
LDO21_RS04405	COG0069	glutamate synthase activity
LDO21_RS04415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LDO21_RS04425	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
LDO21_RS04465	COG3706	GGDEF domain
LDO21_RS04480	COG1053	succinate dehydrogenase
LDO21_RS04485	COG0583	DNA-binding transcription factor activity
LDO21_RS04495	COG1053	succinate dehydrogenase
LDO21_RS04515	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LDO21_RS04520	COG0459	protein refolding
LDO21_RS04525	COG3468	outer membrane autotransporter barrel domain protein
LDO21_RS04540	COG1252	NADH dehydrogenase
LDO21_RS04545	COG0284	orotidine-5'-phosphate decarboxylase activity
LDO21_RS04550	COG1058	Belongs to the CinA family
LDO21_RS04550	COG1546	Belongs to the CinA family
LDO21_RS04555	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LDO21_RS04565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LDO21_RS04570	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LDO21_RS04610	COG3639	organic phosphonate transmembrane transporter activity
LDO21_RS04615	COG3639	organic phosphonate transmembrane transporter activity
LDO21_RS04635	COG0742	ribosomal rna small subunit methyltransferase
LDO21_RS04640	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LDO21_RS04645	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LDO21_RS04650	COG3135	benzoate transporter
LDO21_RS04665	COG0640	Transcriptional regulator
LDO21_RS04695	COG4172	Belongs to the ABC transporter superfamily
LDO21_RS04700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDO21_RS04705	COG0601	transmembrane transport
LDO21_RS04715	COG0280	phosphate acetyltransferase
LDO21_RS04715	COG0281	malic enzyme
LDO21_RS04775	COG0583	DNA-binding transcription factor activity
LDO21_RS04790	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LDO21_RS04795	COG0167	dihydroorotate dehydrogenase activity
LDO21_RS04815	COG1414	Transcriptional regulator
LDO21_RS04820	COG1058	Belongs to the CinA family
LDO21_RS04820	COG1546	Belongs to the CinA family
LDO21_RS04840	COG0513	Belongs to the DEAD box helicase family
LDO21_RS04870	COG0429	hydrolase of the alpha beta-hydrolase fold
LDO21_RS04875	COG4783	chaperone-mediated protein folding
LDO21_RS04890	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LDO21_RS04910	COG0006	proline dipeptidase activity
LDO21_RS04920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LDO21_RS04940	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LDO21_RS04945	COG0632	four-way junction helicase activity
LDO21_RS04960	COG2255	four-way junction helicase activity
LDO21_RS04965	COG0514	ATP-dependent DNA helicase (RecQ)
LDO21_RS04980	COG0288	reversible hydration of carbon dioxide
LDO21_RS04985	COG0154	amidase activity
LDO21_RS04995	COG4211	Belongs to the binding-protein-dependent transport system permease family
LDO21_RS05025	COG1464	Belongs to the NlpA lipoprotein family
LDO21_RS05165	COG1196	nuclear chromosome segregation
LDO21_RS05235	COG2135	peptidase activity
LDO21_RS05250	COG0494	nUDIX hydrolase
LDO21_RS05255	COG0442	prolyl-tRNA aminoacylation
LDO21_RS05260	COG0824	Thioesterase
LDO21_RS05265	COG0811	peptide transport
LDO21_RS05270	COG0848	biopolymer transport protein
LDO21_RS05280	COG0823	Involved in the tonB-independent uptake of proteins
LDO21_RS05295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LDO21_RS05300	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LDO21_RS05330	COG0700	Nucleoside recognition
LDO21_RS05335	COG0469	pyruvate kinase activity
LDO21_RS05340	COG1929	Belongs to the glycerate kinase type-1 family
LDO21_RS05345	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LDO21_RS05350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LDO21_RS05355	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LDO21_RS05365	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LDO21_RS05375	COG2154	pterin-4-alpha-carbinolamine dehydratase
LDO21_RS05400	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LDO21_RS05405	COG0154	amidase activity
LDO21_RS05415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDO21_RS05420	COG0601	transmembrane transport
LDO21_RS05425	COG0747	negative chemotaxis
LDO21_RS05445	COG0019	diaminopimelate decarboxylase activity
LDO21_RS05460	COG2353	YceI-like domain
LDO21_RS05465	COG4774	siderophore transport
LDO21_RS05470	COG3712	iron ion homeostasis
LDO21_RS05510	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LDO21_RS05515	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LDO21_RS05520	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LDO21_RS05525	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LDO21_RS05535	COG0142	geranyltranstransferase activity
LDO21_RS05545	COG0583	DNA-binding transcription factor activity
LDO21_RS05555	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
LDO21_RS05560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LDO21_RS05580	COG2994	toxin metabolic process
LDO21_RS05590	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
LDO21_RS05595	COG2274	protein secretion by the type I secretion system
LDO21_RS05600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LDO21_RS05605	COG1538	Outer membrane efflux protein
LDO21_RS05630	COG0765	amino acid transport
LDO21_RS05635	COG1126	abc transporter atp-binding protein
LDO21_RS05655	COG1028	Short-chain dehydrogenase reductase Sdr
LDO21_RS05665	COG1802	Transcriptional regulator
LDO21_RS05675	COG1802	Transcriptional regulator
LDO21_RS05685	COG0318	PFAM AMP-dependent synthetase and ligase
LDO21_RS05695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LDO21_RS05715	COG0028	Belongs to the TPP enzyme family
LDO21_RS05735	COG0308	aminopeptidase N
LDO21_RS05740	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LDO21_RS05750	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LDO21_RS05755	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LDO21_RS05760	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LDO21_RS05765	COG0560	Phosphoserine phosphatase
LDO21_RS05770	COG0583	DNA-binding transcription factor activity
LDO21_RS05775	COG3181	Tripartite tricarboxylate transporter family receptor
LDO21_RS05780	COG0028	Belongs to the TPP enzyme family
LDO21_RS05795	COG4774	siderophore transport
LDO21_RS05800	COG4774	siderophore transport
LDO21_RS05810	COG1007	ATP synthesis coupled electron transport
LDO21_RS05825	COG0713	ATP synthesis coupled electron transport
LDO21_RS05835	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LDO21_RS05840	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LDO21_RS05845	COG1034	ATP synthesis coupled electron transport
LDO21_RS05855	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
LDO21_RS05860	COG0649	NAD binding
LDO21_RS05865	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LDO21_RS05870	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LDO21_RS05875	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LDO21_RS05880	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LDO21_RS05905	COG0671	phosphoesterase, PA-phosphatase related
LDO21_RS05925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LDO21_RS05935	COG1733	regulation of RNA biosynthetic process
LDO21_RS05940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LDO21_RS05945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LDO21_RS05960	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
LDO21_RS05980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LDO21_RS06000	COG3608	succinylglutamate desuccinylase aspartoacylase
LDO21_RS06005	COG0626	cystathionine gamma-synthase activity
LDO21_RS06010	COG0583	DNA-binding transcription factor activity
LDO21_RS06050	COG3799	methylaspartate ammonia-lyase activity
LDO21_RS06060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LDO21_RS06070	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LDO21_RS06075	COG0149	triose-phosphate isomerase activity
LDO21_RS06095	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LDO21_RS06110	COG1185	polyribonucleotide nucleotidyltransferase activity
LDO21_RS06115	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LDO21_RS06125	COG1183	phosphatidylcholine synthase activity
LDO21_RS06130	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LDO21_RS06135	COG0440	acetolactate synthase activity
LDO21_RS06140	COG0028	Belongs to the TPP enzyme family
LDO21_RS06160	COG0583	DNA-binding transcription factor activity
LDO21_RS06170	COG0477	Major facilitator Superfamily
LDO21_RS06185	COG0617	tRNA 3'-terminal CCA addition
LDO21_RS06195	COG0513	Belongs to the DEAD box helicase family
LDO21_RS06200	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LDO21_RS06210	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LDO21_RS06215	COG2084	Dehydrogenase
LDO21_RS06265	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LDO21_RS06270	COG0129	dihydroxy-acid dehydratase activity
LDO21_RS06275	COG4654	Cytochrome c, class I
LDO21_RS06280	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LDO21_RS06330	COG1473	amidohydrolase
LDO21_RS06335	COG0418	dihydroorotase activity
LDO21_RS06340	COG0488	(ABC) transporter
LDO21_RS06350	COG2001	Belongs to the MraZ family
LDO21_RS06355	COG0275	rRNA processing
LDO21_RS06360	COG3116	cell division
LDO21_RS06370	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LDO21_RS06375	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LDO21_RS06380	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LDO21_RS06390	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LDO21_RS06395	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LDO21_RS06400	COG1181	Belongs to the D-alanine--D-alanine ligase family
LDO21_RS06405	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LDO21_RS06415	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LDO21_RS06420	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LDO21_RS06430	COG0739	heme binding
LDO21_RS06435	COG0653	protein targeting
LDO21_RS06460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LDO21_RS06465	COG1522	sequence-specific DNA binding
LDO21_RS06485	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LDO21_RS06495	COG0557	exoribonuclease II activity
LDO21_RS06500	COG3150	esterase
LDO21_RS06505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LDO21_RS06510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LDO21_RS06515	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LDO21_RS06520	COG0511	ligase activity, forming carbon-carbon bonds
LDO21_RS06525	COG0439	Biotin carboxylase
LDO21_RS06540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LDO21_RS06560	COG1696	Membrane protein involved in D-alanine export
LDO21_RS06565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LDO21_RS06600	COG1522	sequence-specific DNA binding
LDO21_RS06615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LDO21_RS06620	COG1042	CoA-binding domain protein
LDO21_RS06620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LDO21_RS06620	COG0045	succinate-CoA ligase (ADP-forming) activity
LDO21_RS06630	COG1802	Transcriptional regulator
LDO21_RS06635	COG3069	C4-dicarboxylate transmembrane transporter activity
LDO21_RS06640	COG0513	Belongs to the DEAD box helicase family
LDO21_RS06645	COG0346	lactoylglutathione lyase activity
LDO21_RS06650	COG1335	isochorismatase
LDO21_RS06655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LDO21_RS06660	COG1116	anion transmembrane transporter activity
LDO21_RS06675	COG3028	Belongs to the UPF0307 family
LDO21_RS06680	COG0312	modulator of DNA gyrase
LDO21_RS06685	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LDO21_RS06690	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LDO21_RS06695	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LDO21_RS06700	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LDO21_RS06710	COG0316	Belongs to the HesB IscA family
LDO21_RS06715	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LDO21_RS06730	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LDO21_RS06740	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LDO21_RS06745	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LDO21_RS06760	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LDO21_RS06760	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LDO21_RS06790	COG0583	DNA-binding transcription factor activity
LDO21_RS06795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDO21_RS06830	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
LDO21_RS06840	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LDO21_RS06845	COG1845	cytochrome c oxidase, subunit III
LDO21_RS06850	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LDO21_RS06855	COG0640	Transcriptional regulator
LDO21_RS06875	COG3220	belongs to the UPF0276 family
LDO21_RS06920	COG1666	GTP binding
LDO21_RS06955	COG0312	modulator of DNA gyrase
LDO21_RS06960	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LDO21_RS06965	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
LDO21_RS06965	COG3064	Membrane
LDO21_RS06965	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
LDO21_RS06965	COG3210	domain, Protein
LDO21_RS06965	COG3210	domain, Protein
LDO21_RS06965	COG3064	Membrane
LDO21_RS06970	COG0277	FAD linked oxidase domain protein
LDO21_RS06975	COG0277	FAD linked oxidase domain protein
LDO21_RS06980	COG0277	FAD linked oxidase domain protein
LDO21_RS06985	COG0247	lactate metabolic process
LDO21_RS06990	COG2819	hydrolase of the alpha beta superfamily
LDO21_RS07030	COG0583	DNA-binding transcription factor activity
LDO21_RS07035	COG0482	sulfurtransferase activity
LDO21_RS07040	COG0730	response to heat
LDO21_RS07045	COG0625	glutathione transferase activity
LDO21_RS07050	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LDO21_RS07055	COG3909	cytochrome
LDO21_RS07095	COG0154	amidase activity
LDO21_RS07100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDO21_RS07105	COG1024	Enoyl-CoA hydratase
LDO21_RS07120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LDO21_RS07135	COG1028	Short-chain dehydrogenase reductase Sdr
LDO21_RS07140	COG1414	Transcriptional regulator
LDO21_RS07150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LDO21_RS07155	COG0251	oxidation-reduction process
LDO21_RS07160	COG0559	Belongs to the binding-protein-dependent transport system permease family
LDO21_RS07180	COG1902	pentaerythritol trinitrate reductase activity
LDO21_RS07195	COG0583	DNA-binding transcription factor activity
LDO21_RS07205	COG0590	tRNA wobble adenosine to inosine editing
LDO21_RS07210	COG2807	transmembrane transport
LDO21_RS07220	COG3181	Tripartite tricarboxylate transporter family receptor
LDO21_RS07230	COG0154	amidase activity
LDO21_RS07235	COG0307	riboflavin synthase, alpha
LDO21_RS07240	COG3181	Tripartite tricarboxylate transporter family receptor
LDO21_RS07245	COG1522	sequence-specific DNA binding
LDO21_RS07255	COG0318	PFAM AMP-dependent synthetase and ligase
LDO21_RS07265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LDO21_RS07275	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LDO21_RS07285	COG1063	alcohol dehydrogenase
LDO21_RS07310	COG1418	mRNA catabolic process
LDO21_RS07315	COG1448	Aminotransferase
LDO21_RS07320	COG0583	DNA-binding transcription factor activity
LDO21_RS07330	COG0477	Major facilitator Superfamily
LDO21_RS07335	COG1028	Short-chain dehydrogenase reductase Sdr
LDO21_RS07350	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LDO21_RS07355	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LDO21_RS07360	COG0583	DNA-binding transcription factor activity
LDO21_RS07410	COG1028	Short-chain dehydrogenase reductase Sdr
LDO21_RS07415	COG1309	transcriptional regulator
LDO21_RS07425	COG2982	Protein involved in outer membrane biogenesis
LDO21_RS07430	COG2818	Glycosylase
LDO21_RS07450	COG1653	transport
LDO21_RS07465	COG3842	ATPase activity
LDO21_RS07470	COG0395	ABC-type sugar transport system, permease component
LDO21_RS07475	COG1175	transmembrane transport
LDO21_RS07495	COG3181	Tripartite tricarboxylate transporter family receptor
LDO21_RS07500	COG2186	Transcriptional regulator
LDO21_RS07525	COG1454	alcohol dehydrogenase
LDO21_RS07545	COG2011	ABC-type metal ion transport system permease component
LDO21_RS07550	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LDO21_RS07555	COG1501	Belongs to the glycosyl hydrolase 31 family
LDO21_RS07575	COG0318	PFAM AMP-dependent synthetase and ligase
LDO21_RS07580	COG1473	amidohydrolase
LDO21_RS07590	COG2855	membrane
LDO21_RS07600	COG2239	Acts as a magnesium transporter
LDO21_RS07620	COG3181	Tripartite tricarboxylate transporter family receptor
LDO21_RS07630	COG1722	exodeoxyribonuclease VII activity
LDO21_RS07635	COG0142	geranyltranstransferase activity
LDO21_RS07640	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LDO21_RS07645	COG1469	GTP cyclohydrolase I activity
LDO21_RS07650	COG0360	Binds together with S18 to 16S ribosomal RNA
LDO21_RS07655	COG2965	DNA replication, synthesis of RNA primer
LDO21_RS07660	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LDO21_RS07665	COG0359	binds to the 23S rRNA
LDO21_RS07675	COG0305	Participates in initiation and elongation during chromosome replication
LDO21_RS07685	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LDO21_RS07690	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LDO21_RS07695	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LDO21_RS07700	COG3737	Protein of unknown function (DUF498/DUF598)
LDO21_RS07705	COG0436	Aminotransferase
LDO21_RS07730	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
LDO21_RS07760	COG0268	Binds directly to 16S ribosomal RNA
LDO21_RS07770	COG0728	peptidoglycan biosynthetic process
LDO21_RS07780	COG0563	adenylate kinase activity
LDO21_RS07785	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LDO21_RS07790	COG2835	tetraacyldisaccharide 4'-kinase activity
LDO21_RS07795	COG1663	tetraacyldisaccharide 4'-kinase activity
LDO21_RS07800	COG0848	biopolymer transport protein
LDO21_RS07805	COG0811	peptide transport
LDO21_RS07815	COG1570	exodeoxyribonuclease VII activity
LDO21_RS07820	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LDO21_RS07825	COG0038	chloride channel
LDO21_RS07830	COG0183	Belongs to the thiolase family
LDO21_RS07840	COG1278	Cold shock
LDO21_RS07845	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LDO21_RS07855	COG4953	penicillin-binding protein 1C
LDO21_RS07860	COG0542	response to heat
LDO21_RS07865	COG2995	paraquat-inducible protein a
LDO21_RS07870	COG3008	intermembrane lipid transfer
LDO21_RS07870	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LDO21_RS07880	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LDO21_RS07880	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LDO21_RS07880	COG0506	proline dehydrogenase activity
LDO21_RS07915	COG2271	Major facilitator Superfamily
LDO21_RS07920	COG1309	transcriptional regulator
LDO21_RS07955	COG0477	Major facilitator Superfamily
LDO21_RS07965	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LDO21_RS07970	COG1845	cytochrome c oxidase, subunit III
LDO21_RS07975	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LDO21_RS07985	COG1028	Short-chain dehydrogenase reductase Sdr
LDO21_RS08005	COG0789	Transcriptional regulator
LDO21_RS08030	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LDO21_RS08035	COG0697	spore germination
LDO21_RS08045	COG0678	peroxiredoxin activity
LDO21_RS08055	COG0412	Dienelactone hydrolase
LDO21_RS08065	COG0315	cyclic pyranopterin monophosphate synthase activity
LDO21_RS08080	COG0521	Mo-molybdopterin cofactor biosynthetic process
LDO21_RS08085	COG0303	'Molybdopterin
LDO21_RS08090	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LDO21_RS08110	COG0165	Argininosuccinate lyase
LDO21_RS08115	COG0668	transmembrane transport
LDO21_RS08160	COG0747	negative chemotaxis
LDO21_RS08165	COG0601	transmembrane transport
LDO21_RS08170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDO21_RS08175	COG1162	GTPase activity
LDO21_RS08180	COG0501	Belongs to the peptidase M48B family
LDO21_RS08185	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LDO21_RS08195	COG3327	negative regulation of DNA-templated transcription, initiation
LDO21_RS08200	COG3396	Phenylacetate-CoA oxygenase
LDO21_RS08205	COG3460	Phenylacetate-CoA oxygenase
LDO21_RS08210	COG3396	Phenylacetate-CoA oxygenase
LDO21_RS08215	COG2151	metal-sulfur cluster biosynthetic enzyme
LDO21_RS08230	COG1012	belongs to the aldehyde dehydrogenase family
LDO21_RS08235	COG1024	Enoyl-CoA hydratase
LDO21_RS08240	COG2050	protein possibly involved in aromatic compounds catabolism
LDO21_RS08250	COG3539	Fimbrial protein
LDO21_RS08265	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LDO21_RS08270	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LDO21_RS08270	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LDO21_RS08275	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LDO21_RS08280	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LDO21_RS08280	COG0047	phosphoribosylformylglycinamidine synthase activity
LDO21_RS08285	COG3064	Membrane
LDO21_RS08285	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
LDO21_RS08285	COG3210	domain, Protein
LDO21_RS08310	COG0235	Class ii aldolase
LDO21_RS08315	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LDO21_RS08320	COG0720	synthase
LDO21_RS08325	COG0602	queuosine metabolic process
LDO21_RS08350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LDO21_RS08385	COG3181	Tripartite tricarboxylate transporter family receptor
LDO21_RS08415	COG3842	ATPase activity
LDO21_RS08425	COG0395	ABC-type sugar transport system, permease component
LDO21_RS08455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LDO21_RS08460	COG0420	3'-5' exonuclease activity
LDO21_RS08485	COG2197	response regulator
LDO21_RS08505	COG0519	Catalyzes the synthesis of GMP from XMP
LDO21_RS08505	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LDO21_RS08515	COG3550	peptidyl-serine autophosphorylation
LDO21_RS08525	COG0477	Major facilitator Superfamily
LDO21_RS08540	COG1228	amidohydrolase
LDO21_RS08550	COG1116	anion transmembrane transporter activity
LDO21_RS08555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LDO21_RS08590	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LDO21_RS08605	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LDO21_RS08635	COG2814	Major facilitator Superfamily
LDO21_RS08650	COG1280	lysine exporter protein (LysE YggA)
LDO21_RS08670	COG0747	negative chemotaxis
LDO21_RS08675	COG0601	transmembrane transport
LDO21_RS08680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDO21_RS08685	COG4172	Belongs to the ABC transporter superfamily
LDO21_RS08690	COG1609	Transcriptional regulator
LDO21_RS08720	COG0586	Pfam SNARE associated Golgi protein
LDO21_RS08735	COG0500	methyltransferase
LDO21_RS08760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LDO21_RS08770	COG0756	dUTP diphosphatase activity
LDO21_RS08780	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LDO21_RS08785	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LDO21_RS08790	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LDO21_RS08795	COG0072	phenylalanine-tRNA ligase activity
LDO21_RS08795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LDO21_RS08800	COG0776	regulation of translation
LDO21_RS08865	COG0540	Belongs to the ATCase OTCase family
LDO21_RS08870	COG2974	May be involved in recombination
LDO21_RS08880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDO21_RS08885	COG0583	DNA-binding transcription factor activity
LDO21_RS08905	COG1028	Short-chain dehydrogenase reductase Sdr
LDO21_RS08920	COG3842	ATPase activity
LDO21_RS08925	COG1024	Enoyl-CoA hydratase
LDO21_RS08925	COG1250	3-hydroxyacyl-CoA dehydrogenase
LDO21_RS08945	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LDO21_RS08950	COG2137	regulation of response to DNA damage stimulus
LDO21_RS08960	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LDO21_RS08970	COG0045	succinate-CoA ligase (ADP-forming) activity
LDO21_RS08975	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LDO21_RS08980	COG0861	Integral membrane protein TerC family
LDO21_RS08985	COG0861	Integral membrane protein TerC family
LDO21_RS08990	COG0181	hydroxymethylbilane synthase activity
LDO21_RS09045	COG4964	Belongs to the GSP D family
LDO21_RS09070	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LDO21_RS09080	COG0583	DNA-binding transcription factor activity
LDO21_RS09090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LDO21_RS09095	COG4311	Sarcosine oxidase, delta subunit
LDO21_RS09100	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LDO21_RS09100	COG0446	pyridine nucleotide-disulphide oxidoreductase
LDO21_RS09135	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LDO21_RS09140	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LDO21_RS09145	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LDO21_RS09150	COG0735	belongs to the Fur family
LDO21_RS09155	COG0497	DNA recombination
LDO21_RS09160	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LDO21_RS09165	COG1420	regulation of RNA biosynthetic process
LDO21_RS09170	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LDO21_RS09180	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LDO21_RS09190	COG0443	Heat shock 70 kDa protein
LDO21_RS09200	COG0612	Peptidase, M16
LDO21_RS09220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LDO21_RS09265	COG0745	RESPONSE REGULATOR receiver
LDO21_RS09275	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LDO21_RS09280	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LDO21_RS09285	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LDO21_RS09300	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LDO21_RS09315	COG1193	negative regulation of DNA recombination
LDO21_RS09320	COG0492	ferredoxin-NADP+ reductase activity
LDO21_RS09325	COG1674	ftsk spoiiie
LDO21_RS09330	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LDO21_RS09335	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LDO21_RS09340	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LDO21_RS09365	COG3706	GGDEF domain
LDO21_RS09385	COG2814	Major facilitator Superfamily
LDO21_RS09415	COG3486	L-lysine 6-monooxygenase (NADPH) activity
LDO21_RS09430	COG1028	Short-chain dehydrogenase reductase Sdr
LDO21_RS09440	COG3022	response to hydroperoxide
LDO21_RS09455	COG1289	transmembrane transporter activity
LDO21_RS09475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LDO21_RS09485	COG2197	response regulator
LDO21_RS09490	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LDO21_RS09495	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LDO21_RS09500	COG0189	ligase activity
LDO21_RS09510	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LDO21_RS09515	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LDO21_RS09530	COG2423	ornithine cyclodeaminase activity
LDO21_RS09540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDO21_RS09545	COG0765	amino acid transport
LDO21_RS09550	COG0765	amino acid transport
LDO21_RS09555	COG1126	abc transporter atp-binding protein
LDO21_RS09610	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LDO21_RS09620	COG2944	sequence-specific DNA binding
LDO21_RS09630	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LDO21_RS09635	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LDO21_RS09640	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LDO21_RS09645	COG0009	L-threonylcarbamoyladenylate synthase
LDO21_RS09650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDO21_RS09655	COG1414	Transcriptional regulator
LDO21_RS09670	COG0765	amino acid transport
LDO21_RS09675	COG1126	abc transporter atp-binding protein
LDO21_RS09680	COG0028	Belongs to the TPP enzyme family
LDO21_RS09695	COG0028	Belongs to the TPP enzyme family
LDO21_RS09700	COG0583	DNA-binding transcription factor activity
LDO21_RS09705	COG4974	Belongs to the 'phage' integrase family
LDO21_RS09710	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LDO21_RS09715	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
LDO21_RS09730	COG1686	Belongs to the peptidase S11 family
LDO21_RS09740	COG2814	Major facilitator Superfamily
LDO21_RS09755	COG1074	ATP-dependent DNA helicase activity
LDO21_RS09765	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LDO21_RS09770	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LDO21_RS09775	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LDO21_RS09795	COG2321	neutral zinc metallopeptidase
LDO21_RS09800	COG0009	L-threonylcarbamoyladenylate synthase
LDO21_RS09840	COG3360	Dodecin
LDO21_RS09845	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LDO21_RS09850	COG2850	peptidyl-arginine hydroxylation
LDO21_RS09855	COG3539	Fimbrial protein
LDO21_RS09860	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
LDO21_RS09865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LDO21_RS09880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDO21_RS09885	COG0765	amino acid transport
LDO21_RS09890	COG1126	abc transporter atp-binding protein
LDO21_RS09895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LDO21_RS09900	COG1758	RNA polymerase activity
LDO21_RS09905	COG0194	GDP metabolic process
LDO21_RS09910	COG3258	Cytochrome c
LDO21_RS09915	COG2863	cytochrome
LDO21_RS09920	COG1028	Short-chain dehydrogenase reductase Sdr
LDO21_RS09925	COG0791	NLP P60 protein
LDO21_RS09930	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LDO21_RS09945	COG1561	YicC-like family, N-terminal region
LDO21_RS09950	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LDO21_RS09970	COG2199	diguanylate cyclase activity
LDO21_RS09970	COG2200	EAL domain
LDO21_RS09975	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LDO21_RS09985	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LDO21_RS09990	COG0174	glutamine synthetase
LDO21_RS10000	COG2204	response regulator
LDO21_RS10005	COG0583	DNA-binding transcription factor activity
LDO21_RS10010	COG1741	Belongs to the pirin family
LDO21_RS10015	COG1741	Belongs to the pirin family
LDO21_RS10025	COG3842	ATPase activity
LDO21_RS10030	COG1178	ABC-type Fe3 transport system permease component
LDO21_RS10035	COG1840	ABC-type Fe3 transport system, periplasmic component
LDO21_RS10045	COG0583	DNA-binding transcription factor activity
LDO21_RS10055	COG0656	L-ascorbic acid biosynthetic process
LDO21_RS10070	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LDO21_RS10075	COG0583	DNA-binding transcription factor activity
LDO21_RS10090	COG0783	Belongs to the Dps family
LDO21_RS10105	COG0463	Glycosyl transferase, family 2
LDO21_RS10130	COG0438	transferase activity, transferring glycosyl groups
LDO21_RS10145	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LDO21_RS10170	COG0300	oxidoreductase activity
LDO21_RS10210	COG0861	Integral membrane protein TerC family
LDO21_RS10215	COG1028	Short-chain dehydrogenase reductase Sdr
LDO21_RS10235	COG0714	Associated with various cellular activities
LDO21_RS10270	COG3119	arylsulfatase activity
LDO21_RS10295	COG2197	response regulator
LDO21_RS10305	COG2944	sequence-specific DNA binding
LDO21_RS10310	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
LDO21_RS10315	COG0625	glutathione transferase activity
LDO21_RS10345	COG0179	Fumarylacetoacetate (FAA) hydrolase
LDO21_RS10350	COG1028	Short-chain dehydrogenase reductase Sdr
LDO21_RS10395	COG0431	NADPH-dependent FMN reductase
LDO21_RS10425	COG1028	Short-chain dehydrogenase reductase Sdr
LDO21_RS10430	COG0583	DNA-binding transcription factor activity
LDO21_RS10450	COG2111	Na H antiporter
LDO21_RS10450	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LDO21_RS10455	COG1006	Multisubunit Na H antiporter MnhC subunit
LDO21_RS10460	COG0651	ATP synthesis coupled electron transport
LDO21_RS10465	COG1863	multisubunit Na H antiporter MnhE subunit
LDO21_RS10470	COG2212	antiporter activity
LDO21_RS10495	COG0590	tRNA wobble adenosine to inosine editing
LDO21_RS10500	COG1619	proteins homologs of microcin C7 resistance protein MccF
LDO21_RS10505	COG1024	Enoyl-CoA hydratase
LDO21_RS10520	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LDO21_RS10525	COG0488	(ABC) transporter
LDO21_RS10560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LDO21_RS10570	COG2252	PERMEase
LDO21_RS10575	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LDO21_RS10585	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LDO21_RS10590	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LDO21_RS10620	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LDO21_RS10625	COG0789	Transcriptional regulator
LDO21_RS10635	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LDO21_RS10635	COG0678	peroxiredoxin activity
LDO21_RS10645	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LDO21_RS10650	COG0584	glycerophosphoryl diester phosphodiesterase
LDO21_RS10655	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LDO21_RS10665	COG4181	ATPase activity
LDO21_RS10675	COG2823	Periplasmic or secreted lipoprotein
LDO21_RS10685	COG3237	CsbD-like
LDO21_RS10690	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LDO21_RS10690	COG1181	Belongs to the D-alanine--D-alanine ligase family
LDO21_RS10695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LDO21_RS10695	COG0189	ligase activity
LDO21_RS10715	COG2833	Protein of unknown function (DUF455)
LDO21_RS10720	COG2951	lytic endotransglycosylase activity
LDO21_RS10740	COG1522	sequence-specific DNA binding
LDO21_RS10750	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LDO21_RS10755	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LDO21_RS10760	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LDO21_RS10765	COG0196	riboflavin kinase activity
LDO21_RS10770	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LDO21_RS10795	COG0210	DNA helicase
LDO21_RS10800	COG4771	TonB-dependent receptor
LDO21_RS10805	COG0488	(ABC) transporter
LDO21_RS10810	COG2890	protein-(glutamine-N5) methyltransferase activity
LDO21_RS10815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LDO21_RS10820	COG2171	N-acyltransferase activity
LDO21_RS10855	COG1278	Cold shock
LDO21_RS10865	COG1278	Cold shock
LDO21_RS10875	COG0544	peptidyl-prolyl cis-trans isomerase activity
LDO21_RS10880	COG0740	serine-type endopeptidase activity
LDO21_RS10885	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LDO21_RS10890	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LDO21_RS10895	COG0583	DNA-binding transcription factor activity
LDO21_RS10900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDO21_RS10915	COG1024	Enoyl-CoA hydratase
LDO21_RS10925	COG0183	Belongs to the thiolase family
LDO21_RS10930	COG1028	Short-chain dehydrogenase reductase Sdr
LDO21_RS10955	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LDO21_RS10980	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LDO21_RS10990	COG0556	nucleotide-excision repair
LDO21_RS10995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LDO21_RS11005	COG1104	cysteine desulfurase activity
LDO21_RS11010	COG0822	iron-sulfur transferase activity
LDO21_RS11015	COG0316	Belongs to the HesB IscA family
LDO21_RS11020	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LDO21_RS11025	COG0443	Heat shock 70 kDa protein
LDO21_RS11030	COG0633	Ferredoxin
LDO21_RS11050	COG1024	Enoyl-CoA hydratase
LDO21_RS11065	COG3395	kinase activity
LDO21_RS11085	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LDO21_RS11095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LDO21_RS11120	COG0747	negative chemotaxis
LDO21_RS11125	COG0601	transmembrane transport
LDO21_RS11130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDO21_RS11135	COG4172	Belongs to the ABC transporter superfamily
LDO21_RS11140	COG0154	amidase activity
LDO21_RS11180	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LDO21_RS11185	COG0425	Belongs to the sulfur carrier protein TusA family
LDO21_RS11195	COG0228	four-way junction DNA binding
LDO21_RS11200	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LDO21_RS11205	COG0336	Belongs to the RNA methyltransferase TrmD family
LDO21_RS11210	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LDO21_RS11230	COG0642	Histidine kinase
LDO21_RS11245	COG0525	valine-tRNA ligase activity
LDO21_RS11250	COG0105	UTP biosynthetic process
LDO21_RS11255	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LDO21_RS11265	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LDO21_RS11270	COG0124	histidyl-tRNA synthetase
LDO21_RS11275	COG2976	Protein conserved in bacteria
LDO21_RS11280	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LDO21_RS11285	COG1160	GTP binding
LDO21_RS11290	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LDO21_RS11295	COG1923	regulation of RNA biosynthetic process
LDO21_RS11300	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LDO21_RS11305	COG0330	HflC and HflK could
LDO21_RS11310	COG0330	HflC and HflK could
LDO21_RS11315	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
LDO21_RS11320	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LDO21_RS11325	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LDO21_RS11330	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LDO21_RS11345	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LDO21_RS11375	COG0628	permease
LDO21_RS11380	COG0842	Transport permease protein
LDO21_RS11385	COG1131	(ABC) transporter
LDO21_RS11455	COG0156	8-amino-7-oxononanoate synthase activity
LDO21_RS11465	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LDO21_RS11465	COG4106	trans-aconitate 2-methyltransferase activity
LDO21_RS11470	COG1380	Effector of murein hydrolase LrgA
LDO21_RS11475	COG1346	cytolysis
LDO21_RS11490	COG3284	Transcriptional regulator
LDO21_RS11495	COG1012	belongs to the aldehyde dehydrogenase family
LDO21_RS11510	COG2733	membrane
LDO21_RS11515	COG0583	DNA-binding transcription factor activity
LDO21_RS11520	COG0384	phenazine biosynthesis protein PhzF
LDO21_RS11525	COG5507	3-demethylubiquinone-9 3-methyltransferase
LDO21_RS11530	COG2169	Transcriptional regulator
LDO21_RS11560	COG0659	secondary active sulfate transmembrane transporter activity
LDO21_RS11585	COG1132	(ABC) transporter
LDO21_RS11630	COG2207	Transcriptional regulator
LDO21_RS11760	COG2346	COG2346, Truncated hemoglobins
LDO21_RS11795	COG4692	amylo-alpha-1,6-glucosidase activity
LDO21_RS11805	COG0183	Belongs to the thiolase family
LDO21_RS11820	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDO21_RS11825	COG0633	Ferredoxin
LDO21_RS11835	COG1024	Enoyl-CoA hydratase
LDO21_RS11845	COG4638	Rieske (2fe-2S)
LDO21_RS11855	COG0559	Belongs to the binding-protein-dependent transport system permease family
LDO21_RS11875	COG2224	Isocitrate lyase
LDO21_RS11880	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LDO21_RS11880	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LDO21_RS11890	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LDO21_RS11895	COG0322	excinuclease ABC activity
LDO21_RS11900	COG1472	Belongs to the glycosyl hydrolase 3 family
LDO21_RS11905	COG0736	holo-[acyl-carrier-protein] synthase activity
LDO21_RS11910	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LDO21_RS11920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LDO21_RS11925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LDO21_RS11950	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LDO21_RS11965	COG2032	superoxide dismutase activity
LDO21_RS11980	COG1024	Enoyl-CoA hydratase
LDO21_RS11990	COG1802	Transcriptional regulator
LDO21_RS12000	COG0183	Belongs to the thiolase family
LDO21_RS12005	COG1942	4-Oxalocrotonate Tautomerase
LDO21_RS12015	COG4176	ABC-type proline glycine betaine transport system permease component
LDO21_RS12035	COG2814	Major facilitator Superfamily
LDO21_RS12040	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LDO21_RS12045	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LDO21_RS12070	COG2814	Major facilitator Superfamily
LDO21_RS12075	COG0495	leucyl-tRNA aminoacylation
LDO21_RS12090	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LDO21_RS12100	COG0154	amidase activity
LDO21_RS12105	COG1250	3-hydroxyacyl-CoA dehydrogenase
LDO21_RS12160	COG0427	acetyl-CoA hydrolase
LDO21_RS12165	COG0583	DNA-binding transcription factor activity
LDO21_RS12180	COG0730	response to heat
LDO21_RS12185	COG0697	spore germination
LDO21_RS12220	COG2885	chlorophyll binding
LDO21_RS12245	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LDO21_RS12250	COG3384	dioxygenase
LDO21_RS12265	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LDO21_RS12270	COG3474	cytochrome
LDO21_RS12280	COG1595	DNA-templated transcription, initiation
LDO21_RS12295	COG2204	response regulator
LDO21_RS12335	COG4964	Belongs to the GSP D family
LDO21_RS12390	COG1846	Transcriptional regulator
LDO21_RS12395	COG4172	Belongs to the ABC transporter superfamily
LDO21_RS12400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDO21_RS12405	COG0601	transmembrane transport
LDO21_RS12410	COG0747	negative chemotaxis
LDO21_RS12420	COG0598	Magnesium transport protein CorA
LDO21_RS12425	COG0210	DNA helicase
LDO21_RS12440	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LDO21_RS12445	COG1012	belongs to the aldehyde dehydrogenase family
LDO21_RS12450	COG0483	inositol monophosphate 1-phosphatase activity
LDO21_RS12455	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LDO21_RS12465	COG1045	serine acetyltransferase
LDO21_RS12470	COG0166	Belongs to the GPI family
LDO21_RS12500	COG3181	Tripartite tricarboxylate transporter family receptor
LDO21_RS12515	COG1017	nitric oxide dioxygenase activity
LDO21_RS12515	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LDO21_RS12530	COG1335	isochorismatase
LDO21_RS12535	COG2309	aminopeptidase activity
LDO21_RS12545	COG3473	Maleate cis-trans isomerase
LDO21_RS12550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LDO21_RS12555	COG2080	2 iron, 2 sulfur cluster binding
LDO21_RS12560	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LDO21_RS12560	COG2010	Cytochrome c
LDO21_RS12600	COG1846	Transcriptional regulator
LDO21_RS12620	COG1649	PFAM Uncharacterised BCR, COG1649
LDO21_RS12620	COG0726	polysaccharide deacetylase
LDO21_RS12625	COG1215	transferase activity, transferring glycosyl groups
LDO21_RS12635	COG1902	pentaerythritol trinitrate reductase activity
LDO21_RS12660	COG0251	oxidation-reduction process
LDO21_RS12670	COG1832	CoA-binding protein
LDO21_RS12675	COG1414	Transcriptional regulator
LDO21_RS12680	COG0446	pyridine nucleotide-disulphide oxidoreductase
LDO21_RS12680	COG1902	pentaerythritol trinitrate reductase activity
LDO21_RS12690	COG3842	ATPase activity
LDO21_RS12715	COG0583	DNA-binding transcription factor activity
LDO21_RS12725	COG1028	Short-chain dehydrogenase reductase Sdr
LDO21_RS12730	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
LDO21_RS12735	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LDO21_RS12750	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LDO21_RS12750	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LDO21_RS12755	COG1250	3-hydroxyacyl-CoA dehydrogenase
LDO21_RS12780	COG0527	aspartate kinase activity
LDO21_RS12785	COG0037	tRNA processing
LDO21_RS12795	COG0825	malonyl-CoA metabolic process
LDO21_RS12805	COG0215	cysteine-tRNA ligase activity
LDO21_RS12820	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LDO21_RS12825	COG1968	undecaprenyl-diphosphatase activity
LDO21_RS12830	COG1253	flavin adenine dinucleotide binding
LDO21_RS12835	COG0483	inositol monophosphate 1-phosphatase activity
LDO21_RS12855	COG0668	transmembrane transport
LDO21_RS12880	COG0583	DNA-binding transcription factor activity
LDO21_RS12905	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LDO21_RS12920	COG2831	hemolysin activation secretion protein
LDO21_RS12925	COG3539	Fimbrial protein
LDO21_RS12930	COG3188	usher protein
LDO21_RS12935	COG3121	Chaperone
LDO21_RS12945	COG3064	Membrane
LDO21_RS12945	COG3210	domain, Protein
LDO21_RS12945	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
LDO21_RS12950	COG2197	response regulator
LDO21_RS12955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDO21_RS12955	COG2205	protein histidine kinase activity
LDO21_RS12965	COG4336	lyase activity
LDO21_RS13010	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LDO21_RS13020	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LDO21_RS13020	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LDO21_RS13030	COG0028	Belongs to the TPP enzyme family
LDO21_RS13045	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LDO21_RS13055	COG1126	abc transporter atp-binding protein
LDO21_RS13065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDO21_RS13080	COG0084	hydrolase, TatD family'
LDO21_RS13085	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LDO21_RS13090	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LDO21_RS13095	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LDO21_RS13115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LDO21_RS13120	COG1959	2 iron, 2 sulfur cluster binding
LDO21_RS13125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LDO21_RS13125	COG1017	nitric oxide dioxygenase activity
LDO21_RS13155	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LDO21_RS13160	COG2358	TRAP transporter, solute receptor (TAXI family
LDO21_RS13190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LDO21_RS13195	COG1366	Belongs to the anti-sigma-factor antagonist family
LDO21_RS13200	COG2172	sigma factor antagonist activity
LDO21_RS13205	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LDO21_RS13215	COG2208	phosphoserine phosphatase activity
LDO21_RS13215	COG2770	Histidine kinase
LDO21_RS13245	COG1595	DNA-templated transcription, initiation
LDO21_RS13260	COG4792	protein secretion
LDO21_RS13265	COG4791	protein targeting
LDO21_RS13270	COG4794	Type iii secretion
LDO21_RS13275	COG4790	Type iii secretion
LDO21_RS13310	COG4669	(LipO)protein
LDO21_RS13375	COG4789	Type iii secretion
LDO21_RS13410	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LDO21_RS13415	COG0840	transmembrane signaling receptor activity
LDO21_RS13420	COG2233	PERMEase
LDO21_RS13445	COG1840	ABC-type Fe3 transport system, periplasmic component
LDO21_RS13450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LDO21_RS13455	COG1178	ABC-type Fe3 transport system permease component
LDO21_RS13460	COG3842	ATPase activity
LDO21_RS13465	COG0583	DNA-binding transcription factor activity
LDO21_RS13485	COG0501	Belongs to the peptidase M48B family
LDO21_RS13495	COG0697	spore germination
LDO21_RS13505	COG1846	Transcriptional regulator
LDO21_RS13520	COG1566	PFAM secretion protein HlyD family protein
LDO21_RS13525	COG2814	Major facilitator Superfamily
LDO21_RS13530	COG0473	3-isopropylmalate dehydrogenase activity
LDO21_RS13540	COG0747	negative chemotaxis
LDO21_RS13550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDO21_RS13565	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LDO21_RS13590	COG1012	belongs to the aldehyde dehydrogenase family
LDO21_RS13600	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LDO21_RS13605	COG1115	amino acid carrier protein
LDO21_RS13610	COG0433	COG0433 Predicted ATPase
LDO21_RS13615	COG0217	transcriptional regulatory protein
LDO21_RS13620	COG0151	Belongs to the GarS family
LDO21_RS13625	COG0408	coproporphyrinogen oxidase activity
LDO21_RS13630	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LDO21_RS13635	COG0799	negative regulation of ribosome biogenesis
LDO21_RS13640	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LDO21_RS13645	COG0424	maF-like protein
LDO21_RS13650	COG3468	outer membrane autotransporter barrel domain protein
LDO21_RS13685	COG1530	ribonuclease E activity
LDO21_RS13690	COG0077	Prephenate dehydratase
LDO21_RS13705	COG1132	(ABC) transporter
LDO21_RS13710	COG0859	PFAM glycosyl transferase family 9
LDO21_RS13735	COG2194	sulfuric ester hydrolase activity
LDO21_RS13740	COG0438	transferase activity, transferring glycosyl groups
LDO21_RS13745	COG0463	Glycosyl transferase, family 2
LDO21_RS13750	COG0726	polysaccharide deacetylase
LDO21_RS13755	COG0438	transferase activity, transferring glycosyl groups
LDO21_RS13770	COG1643	Atp-dependent helicase
LDO21_RS13775	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LDO21_RS13775	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LDO21_RS13780	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LDO21_RS13790	COG0704	Plays a role in the regulation of phosphate uptake
LDO21_RS13795	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LDO21_RS13800	COG1960	acyl-CoA dehydrogenase activity
LDO21_RS13825	COG1177	transmembrane transport
LDO21_RS13830	COG1176	ABC-type spermidine putrescine transport system, permease component I
LDO21_RS13835	COG3842	ATPase activity
LDO21_RS13840	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LDO21_RS13855	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LDO21_RS13860	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LDO21_RS13870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LDO21_RS13870	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LDO21_RS13890	COG0372	Belongs to the citrate synthase family
LDO21_RS13895	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LDO21_RS13900	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LDO21_RS13905	COG1053	succinate dehydrogenase
LDO21_RS13910	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LDO21_RS13915	COG2009	succinate dehydrogenase
LDO21_RS13920	COG2188	Transcriptional regulator
LDO21_RS13925	COG0039	L-malate dehydrogenase activity
LDO21_RS13955	COG1981	membrane
LDO21_RS13980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LDO21_RS13990	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LDO21_RS14020	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LDO21_RS14025	COG0148	phosphopyruvate hydratase activity
LDO21_RS14035	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LDO21_RS14040	COG0504	CTP synthase activity
LDO21_RS14065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDO21_RS14075	COG0747	negative chemotaxis
LDO21_RS14080	COG4172	Belongs to the ABC transporter superfamily
LDO21_RS14085	COG1446	asparaginase
LDO21_RS14115	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LDO21_RS14130	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
LDO21_RS14135	COG0697	spore germination
LDO21_RS14140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LDO21_RS14150	COG3193	protein, possibly involved in utilization of glycolate and propanediol
LDO21_RS14160	COG0791	NLP P60 protein
LDO21_RS14175	COG0583	DNA-binding transcription factor activity
LDO21_RS14190	COG0583	DNA-binding transcription factor activity
LDO21_RS14200	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LDO21_RS14215	COG0670	Belongs to the BI1 family
LDO21_RS14220	COG3181	Tripartite tricarboxylate transporter family receptor
LDO21_RS14245	COG1381	Involved in DNA repair and RecF pathway recombination
LDO21_RS14250	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LDO21_RS14255	COG0571	ribonuclease III activity
LDO21_RS14260	COG0681	Belongs to the peptidase S26 family
LDO21_RS14265	COG0481	GTPase activity
LDO21_RS14270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LDO21_RS14295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LDO21_RS14300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LDO21_RS14315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LDO21_RS14320	COG0416	fatty acid biosynthetic process
LDO21_RS14325	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LDO21_RS14330	COG1399	metal-binding, possibly nucleic acid-binding protein
LDO21_RS14335	COG0424	maF-like protein
LDO21_RS14345	COG3023	N-Acetylmuramoyl-L-alanine amidase
LDO21_RS14350	COG1289	transmembrane transporter activity
LDO21_RS14365	COG3022	response to hydroperoxide
LDO21_RS14380	COG0135	phosphoribosylanthranilate isomerase activity
LDO21_RS14395	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LDO21_RS14400	COG0101	tRNA pseudouridine synthase activity
LDO21_RS14410	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LDO21_RS14415	COG0473	3-isopropylmalate dehydrogenase activity
LDO21_RS14420	COG0066	3-isopropylmalate dehydratase activity
LDO21_RS14425	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LDO21_RS14435	COG1122	ATPase activity
LDO21_RS14470	COG0243	molybdopterin cofactor binding
LDO21_RS14470	COG3383	formate dehydrogenase (NAD+) activity
LDO21_RS14500	COG0489	protein tyrosine kinase activity
LDO21_RS14505	COG0746	molybdenum cofactor guanylyltransferase activity
LDO21_RS14510	COG0303	'Molybdopterin
LDO21_RS14515	COG1763	Mo-molybdopterin cofactor biosynthetic process
LDO21_RS14525	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LDO21_RS14530	COG5001	Diguanylate cyclase
LDO21_RS14560	COG3842	ATPase activity
LDO21_RS14570	COG0406	alpha-ribazole phosphatase activity
LDO21_RS14580	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LDO21_RS14585	COG0505	Belongs to the CarA family
LDO21_RS14590	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LDO21_RS14615	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LDO21_RS14620	COG1960	acyl-CoA dehydrogenase activity
LDO21_RS14630	COG2867	negative regulation of translational initiation
LDO21_RS14640	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LDO21_RS14645	COG3706	GGDEF domain
LDO21_RS14650	COG0330	HflC and HflK could
LDO21_RS14665	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LDO21_RS14665	COG0519	Catalyzes the synthesis of GMP from XMP
LDO21_RS14675	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LDO21_RS14680	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LDO21_RS14685	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LDO21_RS14690	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LDO21_RS14700	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LDO21_RS14705	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LDO21_RS14710	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
LDO21_RS14715	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LDO21_RS14720	COG0750	zinc metalloprotease
LDO21_RS14725	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LDO21_RS14735	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LDO21_RS14740	COG0233	cytoplasmic translational termination
LDO21_RS14745	COG0528	UMP kinase activity
LDO21_RS14750	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LDO21_RS14755	COG0052	Belongs to the universal ribosomal protein uS2 family
LDO21_RS14760	COG0024	Methionine aminopeptidase
LDO21_RS14765	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LDO21_RS14795	COG0285	dihydrofolate synthase activity
LDO21_RS14830	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LDO21_RS14840	COG1677	Flagellar hook-basal body complex protein FliE
LDO21_RS14850	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LDO21_RS14860	COG1157	protein secretion by the type III secretion system
LDO21_RS14885	COG1580	Controls the rotational direction of flagella during chemotaxis
LDO21_RS14905	COG1338	Plays a role in the flagellum-specific transport system
LDO21_RS14925	COG0840	transmembrane signaling receptor activity
LDO21_RS14930	COG0840	transmembrane signaling receptor activity
LDO21_RS14935	COG0840	transmembrane signaling receptor activity
LDO21_RS14945	COG1256	bacterial-type flagellum assembly
LDO21_RS14955	COG1706	bacterial-type flagellum-dependent cell motility
LDO21_RS14960	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LDO21_RS14975	COG1749	Flagellar hook protein flgE
LDO21_RS14985	COG1558	bacterial-type flagellum-dependent cell motility
LDO21_RS14990	COG1815	bacterial-type flagellum-dependent cell motility
LDO21_RS15030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDO21_RS15035	COG0765	amino acid transport
LDO21_RS15040	COG1126	abc transporter atp-binding protein
LDO21_RS15055	COG4948	Mandelate Racemase Muconate Lactonizing
LDO21_RS15060	COG3181	Tripartite tricarboxylate transporter family receptor
LDO21_RS15070	COG0066	3-isopropylmalate dehydratase activity
LDO21_RS15085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDO21_RS15095	COG3181	Tripartite tricarboxylate transporter family receptor
LDO21_RS15105	COG1802	Transcriptional regulator
LDO21_RS15120	COG0583	DNA-binding transcription factor activity
LDO21_RS15140	COG1695	Transcriptional regulator
LDO21_RS15150	COG3568	Endonuclease Exonuclease Phosphatase
LDO21_RS15155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LDO21_RS15170	COG0392	lysyltransferase activity
LDO21_RS15210	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LDO21_RS15220	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LDO21_RS15230	COG1640	4-alpha-glucanotransferase
LDO21_RS15245	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LDO21_RS15275	COG0667	Aldo Keto reductase
LDO21_RS15290	COG2259	Doxx family
LDO21_RS15320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDO21_RS15345	COG0386	Belongs to the glutathione peroxidase family
LDO21_RS15350	COG0625	glutathione transferase activity
LDO21_RS15365	COG0095	Lipoate-protein ligase
LDO21_RS15380	COG0688	phosphatidylethanolamine metabolic process
LDO21_RS15390	COG1464	Belongs to the NlpA lipoprotein family
LDO21_RS15405	COG2363	Small membrane protein
LDO21_RS15430	COG3842	ATPase activity
LDO21_RS15435	COG0395	ABC-type sugar transport system, permease component
LDO21_RS15440	COG1175	transmembrane transport
LDO21_RS15445	COG1653	transport
LDO21_RS15455	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LDO21_RS15470	COG0559	Belongs to the binding-protein-dependent transport system permease family
LDO21_RS15505	COG0697	spore germination
LDO21_RS15515	COG2311	Membrane
LDO21_RS15540	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LDO21_RS15550	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LDO21_RS15555	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LDO21_RS15560	COG1760	l-serine dehydratase
LDO21_RS15565	COG1283	sodium-dependent phosphate transmembrane transporter activity
LDO21_RS15570	COG0412	Dienelactone hydrolase
LDO21_RS15585	COG1611	Belongs to the LOG family
LDO21_RS15605	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LDO21_RS15610	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LDO21_RS15615	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LDO21_RS15620	COG0195	Participates in both transcription termination and antitermination
LDO21_RS15620	COG2251	uridine kinase activity
LDO21_RS15625	COG0779	Required for maturation of 30S ribosomal subunits
LDO21_RS15630	COG1187	pseudouridine synthase activity
LDO21_RS15635	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LDO21_RS15645	COG0583	DNA-binding transcription factor activity
LDO21_RS15655	COG0523	cobalamin synthesis protein
LDO21_RS15675	COG0625	glutathione transferase activity
LDO21_RS15680	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LDO21_RS15685	COG1047	Peptidyl-prolyl cis-trans
LDO21_RS15690	COG2003	Belongs to the UPF0758 family
LDO21_RS15695	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
LDO21_RS15700	COG3483	tryptophan 2,3-dioxygenase activity
LDO21_RS15705	COG0254	rRNA binding
LDO21_RS15715	COG0534	Mate efflux family protein
LDO21_RS15735	COG2304	oxidoreductase activity
LDO21_RS15755	COG1028	Short-chain dehydrogenase reductase Sdr
LDO21_RS15760	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LDO21_RS15765	COG1562	ergosterol biosynthetic process
LDO21_RS15770	COG1562	ergosterol biosynthetic process
LDO21_RS15775	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
LDO21_RS15775	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
LDO21_RS15780	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LDO21_RS15790	COG0842	Transport permease protein
LDO21_RS15795	COG1131	(ABC) transporter
LDO21_RS15815	COG1477	protein flavinylation
LDO21_RS15830	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LDO21_RS15845	COG5564	TIM-barrel signal transduction protein
LDO21_RS15850	COG5441	Belongs to the UPF0261 family
LDO21_RS15860	COG3468	outer membrane autotransporter barrel domain protein
LDO21_RS15865	COG3468	outer membrane autotransporter barrel domain protein
LDO21_RS15880	COG0542	response to heat
LDO21_RS15885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LDO21_RS15900	COG0494	nUDIX hydrolase
LDO21_RS15905	COG3530	Putative quorum-sensing-regulated virulence factor
LDO21_RS15915	COG1595	DNA-templated transcription, initiation
LDO21_RS15920	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LDO21_RS15955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDO21_RS15960	COG0765	amino acid transport
LDO21_RS15965	COG0765	amino acid transport
LDO21_RS15995	COG2988	succinylglutamate desuccinylase activity
LDO21_RS16020	COG3181	Tripartite tricarboxylate transporter family receptor
LDO21_RS16025	COG2084	Dehydrogenase
LDO21_RS16040	COG1619	proteins homologs of microcin C7 resistance protein MccF
LDO21_RS16055	COG2814	Major facilitator Superfamily
LDO21_RS16065	COG0583	DNA-binding transcription factor activity
LDO21_RS16110	COG0672	)-iron permease
LDO21_RS16125	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
LDO21_RS16130	COG1028	Short-chain dehydrogenase reductase Sdr
LDO21_RS16135	COG3243	poly(R)-hydroxyalkanoic acid synthase
LDO21_RS16145	COG0564	pseudouridine synthase activity
LDO21_RS16155	COG1199	ATP-dependent helicase activity
LDO21_RS16160	COG2183	response to ionizing radiation
LDO21_RS16165	COG0180	Tryptophanyl-tRNA synthetase
LDO21_RS16190	COG3181	Tripartite tricarboxylate transporter family receptor
LDO21_RS16200	COG0583	DNA-binding transcription factor activity
LDO21_RS16205	COG1028	Short-chain dehydrogenase reductase Sdr
LDO21_RS16210	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LDO21_RS16215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LDO21_RS16220	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDO21_RS16225	COG0567	Dehydrogenase, E1 component
LDO21_RS16235	COG1522	sequence-specific DNA binding
LDO21_RS16245	COG0280	phosphate acetyltransferase
LDO21_RS16245	COG0281	malic enzyme
LDO21_RS16250	COG3539	Fimbrial protein
LDO21_RS16265	COG0613	PHP domain protein
LDO21_RS16295	COG0084	hydrolase, TatD family'
LDO21_RS16300	COG1136	(ABC) transporter
LDO21_RS16315	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LDO21_RS16325	COG1028	Short-chain dehydrogenase reductase Sdr
LDO21_RS16330	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LDO21_RS16345	COG1022	Amp-dependent synthetase and ligase
LDO21_RS16380	COG2205	protein histidine kinase activity
LDO21_RS16385	COG0745	RESPONSE REGULATOR receiver
LDO21_RS16390	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LDO21_RS16400	COG1295	ribonuclease BN
LDO21_RS16415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LDO21_RS16445	COG1534	Rna-binding protein
LDO21_RS16450	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LDO21_RS16460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LDO21_RS16470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LDO21_RS16480	COG0248	Ppx GppA phosphatase
LDO21_RS16505	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LDO21_RS16525	COG2732	(Barnase) inhibitor
LDO21_RS16535	COG0281	malic enzyme
LDO21_RS16535	COG0280	phosphate acetyltransferase
LDO21_RS16545	COG0436	Aminotransferase
LDO21_RS16550	COG0741	lytic transglycosylase activity
LDO21_RS16555	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LDO21_RS16580	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LDO21_RS16580	COG1648	precorrin-2 dehydrogenase activity
LDO21_RS16595	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LDO21_RS16600	COG2027	D-alanyl-D-alanine carboxypeptidase
LDO21_RS16605	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LDO21_RS16610	COG0343	queuine tRNA-ribosyltransferase activity
LDO21_RS16615	COG1862	Preprotein translocase
LDO21_RS16620	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LDO21_RS16625	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LDO21_RS16645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LDO21_RS16650	COG1702	phosphate starvation-inducible protein PhoH
LDO21_RS16655	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LDO21_RS16660	COG4535	Mg2 and Co2 transporter CorC
LDO21_RS16670	COG0667	Aldo Keto reductase
LDO21_RS16695	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LDO21_RS16700	COG0745	RESPONSE REGULATOR receiver
LDO21_RS16705	COG2201	protein-glutamate methylesterase activity
LDO21_RS16715	COG0840	transmembrane signaling receptor activity
LDO21_RS16730	COG0745	RESPONSE REGULATOR receiver
LDO21_RS16765	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LDO21_RS16775	COG0739	heme binding
LDO21_RS16785	COG0521	Mo-molybdopterin cofactor biosynthetic process
LDO21_RS16835	COG0625	glutathione transferase activity
LDO21_RS16850	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LDO21_RS16855	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LDO21_RS16860	COG0126	phosphoglycerate kinase activity
LDO21_RS16865	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LDO21_RS16870	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LDO21_RS16875	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LDO21_RS16885	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LDO21_RS16890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LDO21_RS16895	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDO21_RS16900	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LDO21_RS16910	COG4566	intracellular signal transduction
LDO21_RS16915	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LDO21_RS16920	COG0339	signal peptide processing
LDO21_RS16925	COG1999	signal sequence binding
LDO21_RS16955	COG1187	pseudouridine synthase activity
LDO21_RS16960	COG3161	chorismate lyase activity
LDO21_RS16975	COG0667	Aldo Keto reductase
LDO21_RS16990	COG0335	large ribosomal subunit rRNA binding
LDO21_RS17025	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LDO21_RS17045	COG0450	alkyl hydroperoxide reductase
LDO21_RS17050	COG1960	acyl-CoA dehydrogenase activity
LDO21_RS17065	COG0123	including yeast histone deacetylase and acetoin utilization protein
LDO21_RS17070	COG2951	lytic endotransglycosylase activity
LDO21_RS17085	COG1555	photosystem II stabilization
LDO21_RS17085	COG1596	polysaccharide export
LDO21_RS17090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LDO21_RS17095	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LDO21_RS17100	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LDO21_RS17120	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LDO21_RS17125	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LDO21_RS17130	COG0287	Prephenate dehydrogenase
LDO21_RS17140	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LDO21_RS17155	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LDO21_RS17165	COG2814	Major facilitator Superfamily
LDO21_RS17190	COG0583	DNA-binding transcription factor activity
LDO21_RS17225	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LDO21_RS17240	COG0667	Aldo Keto reductase
LDO21_RS17250	COG5265	(ABC) transporter
LDO21_RS17295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LDO21_RS17300	COG0439	Biotin carboxylase
LDO21_RS17305	COG2188	Transcriptional regulator
LDO21_RS17330	COG0511	ligase activity, forming carbon-carbon bonds
LDO21_RS17340	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LDO21_RS17345	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LDO21_RS17365	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
LDO21_RS17385	COG0500	methyltransferase
LDO21_RS17390	COG5265	(ABC) transporter
LDO21_RS17405	COG1950	PFAM Membrane protein of
LDO21_RS17410	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LDO21_RS17425	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LDO21_RS17435	COG1560	Kdo2-lipid A biosynthetic process
LDO21_RS17440	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LDO21_RS17450	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LDO21_RS17460	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
LDO21_RS17470	COG0803	Belongs to the bacterial solute-binding protein 9 family
LDO21_RS17490	COG0735	belongs to the Fur family
LDO21_RS17495	COG0523	cobalamin synthesis protein
LDO21_RS17505	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LDO21_RS17510	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LDO21_RS17520	COG2096	Adenosyltransferase
LDO21_RS17530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LDO21_RS17535	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LDO21_RS17610	COG0405	Gamma-glutamyltransferase
LDO21_RS17620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LDO21_RS17645	COG1309	transcriptional regulator
LDO21_RS17660	COG0745	RESPONSE REGULATOR receiver
LDO21_RS17705	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LDO21_RS17725	COG0582	viral genome integration into host DNA
LDO21_RS17730	COG0012	GTP binding
LDO21_RS17740	COG0193	aminoacyl-tRNA hydrolase activity
LDO21_RS17745	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LDO21_RS17750	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LDO21_RS17760	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LDO21_RS17765	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LDO21_RS17775	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LDO21_RS17800	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LDO21_RS17810	COG1368	sulfuric ester hydrolase activity
LDO21_RS17815	COG0642	Histidine kinase
LDO21_RS17820	COG0745	RESPONSE REGULATOR receiver
LDO21_RS17825	COG0277	FAD linked oxidase domain protein
LDO21_RS17840	COG0166	Belongs to the GPI family
LDO21_RS17845	COG0438	transferase activity, transferring glycosyl groups
LDO21_RS17850	COG0438	transferase activity, transferring glycosyl groups
LDO21_RS17865	COG0438	transferase activity, transferring glycosyl groups
LDO21_RS17880	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LDO21_RS17885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LDO21_RS17890	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
LDO21_RS17900	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LDO21_RS17910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LDO21_RS17915	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LDO21_RS17925	COG0747	negative chemotaxis
LDO21_RS17930	COG0601	transmembrane transport
LDO21_RS17935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDO21_RS17955	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LDO21_RS17970	COG0804	urea catabolic process
LDO21_RS17975	COG0832	Belongs to the urease beta subunit family
LDO21_RS17985	COG0831	urea catabolic process
LDO21_RS17990	COG0829	nickel cation binding
LDO21_RS18020	COG2188	Transcriptional regulator
LDO21_RS18045	COG2719	SpoVR family
LDO21_RS18050	COG2718	Belongs to the UPF0229 family
LDO21_RS18065	COG1028	Short-chain dehydrogenase reductase Sdr
LDO21_RS18070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDO21_RS18085	COG1960	acyl-CoA dehydrogenase activity
LDO21_RS18135	COG2030	dehydratase
LDO21_RS18180	COG0328	RNA-DNA hybrid ribonuclease activity
LDO21_RS18185	COG2226	methyltransferase
LDO21_RS18190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LDO21_RS18195	COG0741	lytic transglycosylase activity
LDO21_RS18195	COG1388	LysM domain
LDO21_RS18215	COG2979	Protein of unknown function (DUF533)
LDO21_RS18250	COG1271	oxidase subunit
LDO21_RS18255	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LDO21_RS18260	COG0850	regulation of cytokinetic process
LDO21_RS18265	COG2894	cell division
LDO21_RS18270	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LDO21_RS18290	COG0488	(ABC) transporter
LDO21_RS18315	COG1215	transferase activity, transferring glycosyl groups
LDO21_RS18325	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LDO21_RS18335	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LDO21_RS18355	COG0318	PFAM AMP-dependent synthetase and ligase
LDO21_RS18360	COG2188	Transcriptional regulator
LDO21_RS18365	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LDO21_RS18370	COG2814	Major facilitator Superfamily
LDO21_RS18380	COG0259	pyridoxamine-phosphate oxidase activity
LDO21_RS18385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LDO21_RS18400	COG0583	DNA-binding transcription factor activity
LDO21_RS18435	COG0134	indole-3-glycerol-phosphate synthase activity
LDO21_RS18440	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LDO21_RS18445	COG0512	Glutamine amidotransferase of anthranilate synthase
LDO21_RS18455	COG0546	phosphoglycolate phosphatase activity
LDO21_RS18460	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LDO21_RS18465	COG2967	ApaG domain
LDO21_RS18470	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LDO21_RS18475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LDO21_RS18480	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LDO21_RS18485	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LDO21_RS18495	COG0037	tRNA processing
LDO21_RS18505	COG3634	alkyl hydroperoxide reductase activity
LDO21_RS18510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LDO21_RS18515	COG1024	Enoyl-CoA hydratase
LDO21_RS18540	COG0356	it plays a direct role in the translocation of protons across the membrane
LDO21_RS18550	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LDO21_RS18555	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LDO21_RS18560	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LDO21_RS18565	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LDO21_RS18570	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LDO21_RS18575	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LDO21_RS18585	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LDO21_RS18590	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LDO21_RS18595	COG0210	DNA helicase
LDO21_RS18605	COG2195	Cleaves the N-terminal amino acid of tripeptides
LDO21_RS18620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDO21_RS18625	COG0601	transmembrane transport
LDO21_RS18645	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LDO21_RS18650	COG1024	Enoyl-CoA hydratase
LDO21_RS18655	COG1024	Enoyl-CoA hydratase
LDO21_RS18710	COG2132	Multicopper oxidase
LDO21_RS18720	COG1250	3-hydroxyacyl-CoA dehydrogenase
LDO21_RS18720	COG1024	Enoyl-CoA hydratase
LDO21_RS18730	COG1414	Transcriptional regulator
LDO21_RS18740	COG0154	amidase activity
LDO21_RS18770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LDO21_RS18775	COG3568	Endonuclease Exonuclease Phosphatase
LDO21_RS18780	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LDO21_RS18815	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LDO21_RS18825	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LDO21_RS18840	COG1137	ATPase activity
LDO21_RS18855	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LDO21_RS18860	COG2010	Cytochrome c
LDO21_RS18860	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LDO21_RS18870	COG1660	Displays ATPase and GTPase activities
LDO21_RS18875	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LDO21_RS18915	COG3181	Tripartite tricarboxylate transporter family receptor
LDO21_RS18925	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LDO21_RS18930	COG2890	protein-(glutamine-N5) methyltransferase activity
LDO21_RS18935	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LDO21_RS18940	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LDO21_RS18980	COG1960	acyl-CoA dehydrogenase activity
LDO21_RS18990	COG0183	Belongs to the thiolase family
LDO21_RS18995	COG1522	sequence-specific DNA binding
LDO21_RS19000	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LDO21_RS19020	COG1024	Enoyl-CoA hydratase
LDO21_RS19035	COG0604	alcohol dehydrogenase
LDO21_RS19040	COG2072	flavoprotein involved in K transport
LDO21_RS19055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LDO21_RS19065	COG1960	acyl-CoA dehydrogenase activity
LDO21_RS19070	COG1960	acyl-CoA dehydrogenase activity
LDO21_RS19075	COG0277	FAD linked oxidase domain protein
LDO21_RS19085	COG3181	Tripartite tricarboxylate transporter family receptor
LDO21_RS19105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LDO21_RS19115	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LDO21_RS19120	COG3181	Tripartite tricarboxylate transporter family receptor
LDO21_RS19125	COG1960	acyl-CoA dehydrogenase activity
LDO21_RS19145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LDO21_RS19150	COG1024	Enoyl-CoA hydratase
LDO21_RS19155	COG1960	acyl-CoA dehydrogenase activity
LDO21_RS19175	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LDO21_RS19180	COG0022	dehydrogenase e1 component
LDO21_RS19185	COG1024	Enoyl-CoA hydratase
LDO21_RS19190	COG0508	dehydrogenase complex catalyzes the overall conversion of
LDO21_RS19210	COG0683	leucine binding
LDO21_RS19215	COG0559	Belongs to the binding-protein-dependent transport system permease family
LDO21_RS19220	COG0411	ABC transporter
LDO21_RS19230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LDO21_RS19245	COG3181	Tripartite tricarboxylate transporter family receptor
LDO21_RS19270	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LDO21_RS19275	COG0793	Belongs to the peptidase S41A family
LDO21_RS19280	COG4942	peptidase
LDO21_RS19285	COG0588	phosphoglycerate mutase activity
LDO21_RS19290	COG1054	Belongs to the UPF0176 family
LDO21_RS19295	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LDO21_RS19300	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LDO21_RS19305	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LDO21_RS19310	COG3181	Tripartite tricarboxylate transporter family receptor
LDO21_RS19325	COG2226	methyltransferase
LDO21_RS19330	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LDO21_RS19345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LDO21_RS19350	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LDO21_RS19375	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LDO21_RS19400	COG1335	isochorismatase
LDO21_RS19405	COG2309	aminopeptidase activity
LDO21_RS19415	COG3473	Maleate cis-trans isomerase
LDO21_RS19425	COG2068	MobA-Related Protein
LDO21_RS19450	COG2204	response regulator
LDO21_RS19455	COG5000	phosphorelay sensor kinase activity
LDO21_RS19465	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LDO21_RS19465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LDO21_RS19475	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
LDO21_RS19500	COG0583	DNA-binding transcription factor activity
LDO21_RS19520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LDO21_RS19525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDO21_RS19540	COG0758	DNA mediated transformation
LDO21_RS19545	COG1522	sequence-specific DNA binding
LDO21_RS19555	COG0242	peptide deformylase activity
LDO21_RS19565	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LDO21_RS19575	COG0546	phosphoglycolate phosphatase activity
LDO21_RS19595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LDO21_RS19600	COG1942	4-Oxalocrotonate Tautomerase
LDO21_RS19605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LDO21_RS19625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LDO21_RS19645	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LDO21_RS19650	COG1024	Enoyl-CoA hydratase
LDO21_RS19655	COG1414	Transcriptional regulator
LDO21_RS19660	COG0318	PFAM AMP-dependent synthetase and ligase
LDO21_RS19665	COG3181	Tripartite tricarboxylate transporter family receptor
LDO21_RS19705	COG3422	double-strand break repair
LDO21_RS19710	COG0330	HflC and HflK could
LDO21_RS19720	COG0251	oxidation-reduction process
LDO21_RS19760	COG3723	Recombinational DNA repair protein, rece pathway
LDO21_RS19790	COG0582	viral genome integration into host DNA
LDO21_RS19825	COG0706	membrane insertase activity
LDO21_RS19830	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LDO21_RS19835	COG0594	ribonuclease P activity
LDO21_RS19840	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LDO21_RS19870	COG0318	PFAM AMP-dependent synthetase and ligase
LDO21_RS19900	COG0477	Major facilitator Superfamily
LDO21_RS19970	COG2333	competence protein COMEC
LDO21_RS19970	COG0658	competence protein
LDO21_RS20010	COG4608	Belongs to the ABC transporter superfamily