locus-tag	class	description
RD15_RS00005	COG0445	tRNA wobble uridine modification
RD15_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
RD15_RS00015	COG1192	Involved in chromosome partitioning
RD15_RS00025	COG1475	DNA binding
RD15_RS00030	COG0252	asparaginase activity
RD15_RS00055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RD15_RS00065	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RD15_RS00075	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RD15_RS00080	COG0081	regulation of translation
RD15_RS00085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RD15_RS00090	COG0222	ribosome binding
RD15_RS00095	COG0085	RNA polymerase activity
RD15_RS00100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RD15_RS00140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD15_RS00165	COG1024	Enoyl-CoA hydratase
RD15_RS00185	COG0752	glycyl-tRNA synthetase alpha subunit
RD15_RS00190	COG0751	glycine-tRNA ligase activity
RD15_RS00195	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RD15_RS00200	COG0204	Acyl-transferase
RD15_RS00215	COG0242	peptide deformylase activity
RD15_RS00250	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RD15_RS00255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RD15_RS00260	COG2813	Specifically methylates the guanine in position
RD15_RS00260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RD15_RS00270	COG2223	nitrite transmembrane transporter activity
RD15_RS00280	COG1794	racemase activity, acting on amino acids and derivatives
RD15_RS00285	COG1126	abc transporter atp-binding protein
RD15_RS00290	COG0765	amino acid transport
RD15_RS00295	COG0765	amino acid transport
RD15_RS00300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD15_RS00360	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD15_RS00390	COG0326	Molecular chaperone. Has ATPase activity
RD15_RS00395	COG0625	glutathione transferase activity
RD15_RS00410	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RD15_RS00415	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RD15_RS00445	COG0438	transferase activity, transferring glycosyl groups
RD15_RS00450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RD15_RS00455	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RD15_RS00485	COG0859	PFAM glycosyl transferase family 9
RD15_RS00500	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
RD15_RS00510	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RD15_RS00515	COG1127	ABC transporter
RD15_RS00540	COG1686	Belongs to the peptidase S11 family
RD15_RS00550	COG2921	Belongs to the UPF0250 family
RD15_RS00555	COG0321	lipoyl(octanoyl) transferase activity
RD15_RS00560	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RD15_RS00595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RD15_RS00605	COG0018	arginyl-trna synthetase
RD15_RS00625	COG0395	ABC-type sugar transport system, permease component
RD15_RS00630	COG1175	transmembrane transport
RD15_RS00635	COG1653	transport
RD15_RS00640	COG3842	ATPase activity
RD15_RS00645	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RD15_RS00660	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RD15_RS00680	COG1609	Transcriptional regulator
RD15_RS00690	COG0154	amidase activity
RD15_RS00695	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RD15_RS00705	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RD15_RS00715	COG0583	DNA-binding transcription factor activity
RD15_RS00730	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RD15_RS00735	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RD15_RS00750	COG1802	Transcriptional regulator
RD15_RS00765	COG1024	Enoyl-CoA hydratase
RD15_RS00780	COG3181	Tripartite tricarboxylate transporter family receptor
RD15_RS00795	COG1984	allophanate hydrolase subunit 2
RD15_RS00800	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RD15_RS00810	COG0583	DNA-binding transcription factor activity
RD15_RS00815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RD15_RS00825	COG5002	protein histidine kinase activity
RD15_RS00835	COG5002	protein histidine kinase activity
RD15_RS00840	COG0745	RESPONSE REGULATOR receiver
RD15_RS00845	COG2226	methyltransferase
RD15_RS00860	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RD15_RS00880	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
RD15_RS00890	COG0513	Belongs to the DEAD box helicase family
RD15_RS00895	COG1280	lysine exporter protein (LysE YggA)
RD15_RS00900	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
RD15_RS00935	COG1054	Belongs to the UPF0176 family
RD15_RS00940	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RD15_RS00940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RD15_RS00950	COG0489	protein tyrosine kinase activity
RD15_RS00965	COG0717	Belongs to the dCTP deaminase family
RD15_RS00995	COG2081	HI0933 family
RD15_RS01005	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RD15_RS01015	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RD15_RS01020	COG0509	glycine decarboxylation via glycine cleavage system
RD15_RS01025	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RD15_RS01025	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RD15_RS01065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RD15_RS01080	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RD15_RS01090	COG1414	Transcriptional regulator
RD15_RS01095	COG1028	Short-chain dehydrogenase reductase Sdr
RD15_RS01100	COG2031	fatty acid transporter
RD15_RS01105	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD15_RS01115	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
RD15_RS01120	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
RD15_RS01130	COG4257	antibiotic catabolic process
RD15_RS01150	COG1012	belongs to the aldehyde dehydrogenase family
RD15_RS01155	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
RD15_RS01160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RD15_RS01240	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
RD15_RS01250	COG0583	DNA-binding transcription factor activity
RD15_RS01255	COG2814	Major facilitator Superfamily
RD15_RS01260	COG0129	dihydroxy-acid dehydratase activity
RD15_RS01265	COG2207	Transcriptional regulator
RD15_RS01270	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RD15_RS01280	COG0657	acetylesterase activity
RD15_RS01285	COG0747	negative chemotaxis
RD15_RS01290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RD15_RS01295	COG2808	Putative FMN-binding domain
RD15_RS01310	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RD15_RS01315	COG1970	mechanosensitive ion channel activity
RD15_RS01320	COG0723	plastoquinol--plastocyanin reductase activity
RD15_RS01325	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RD15_RS01330	COG2857	Cytochrome c1
RD15_RS01335	COG0625	glutathione transferase activity
RD15_RS01365	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RD15_RS01380	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RD15_RS01385	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
RD15_RS01390	COG4988	ABC transporter
RD15_RS01400	COG1294	oxidase, subunit
RD15_RS01425	COG1960	acyl-CoA dehydrogenase activity
RD15_RS01435	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD15_RS01440	COG0405	Gamma-glutamyltransferase
RD15_RS01450	COG3181	Tripartite tricarboxylate transporter family receptor
RD15_RS01460	COG0114	fumarate hydratase activity
RD15_RS01465	COG0802	atpase or kinase
RD15_RS01470	COG0860	N-Acetylmuramoyl-L-alanine amidase
RD15_RS01475	COG0586	Pfam SNARE associated Golgi protein
RD15_RS01480	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RD15_RS01485	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RD15_RS01490	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RD15_RS01505	COG0617	tRNA 3'-terminal CCA addition
RD15_RS01530	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD15_RS01535	COG2188	Transcriptional regulator
RD15_RS01545	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RD15_RS01555	COG1028	Short-chain dehydrogenase reductase Sdr
RD15_RS01565	COG1902	pentaerythritol trinitrate reductase activity
RD15_RS01575	COG1024	Enoyl-CoA hydratase
RD15_RS01580	COG1960	acyl-CoA dehydrogenase activity
RD15_RS01605	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RD15_RS01610	COG0352	thiamine-phosphate diphosphorylase activity
RD15_RS01625	COG1678	Uncharacterized ACR, COG1678
RD15_RS01630	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RD15_RS01635	COG0540	Belongs to the ATCase OTCase family
RD15_RS01650	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RD15_RS01660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RD15_RS01695	COG1234	tRNA 3'-trailer cleavage
RD15_RS01740	COG1683	Conserved Protein
RD15_RS01745	COG1120	ATPase activity
RD15_RS01750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RD15_RS01755	COG4558	Periplasmic binding protein
RD15_RS01760	COG3720	iron ion transport
RD15_RS01770	COG3712	iron ion homeostasis
RD15_RS01775	COG1595	DNA-templated transcription, initiation
RD15_RS01810	COG1802	Transcriptional regulator
RD15_RS01820	COG3069	C4-dicarboxylate transmembrane transporter activity
RD15_RS01830	COG1012	belongs to the aldehyde dehydrogenase family
RD15_RS01865	COG2860	membrane
RD15_RS01870	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RD15_RS01875	COG0708	Exodeoxyribonuclease III
RD15_RS01880	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RD15_RS01885	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RD15_RS01890	COG0154	amidase activity
RD15_RS01895	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RD15_RS01900	COG1077	Cell shape determining protein MreB Mrl
RD15_RS01905	COG1792	Involved in formation and maintenance of cell shape
RD15_RS01915	COG0768	penicillin binding
RD15_RS01920	COG0772	Belongs to the SEDS family
RD15_RS01925	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RD15_RS01930	COG0471	metal ion transport
RD15_RS01935	COG1309	transcriptional regulator
RD15_RS01945	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RD15_RS01960	COG2823	Periplasmic or secreted lipoprotein
RD15_RS01965	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
RD15_RS01980	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RD15_RS02000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD15_RS02010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD15_RS02040	COG0492	ferredoxin-NADP+ reductase activity
RD15_RS02050	COG3181	Tripartite tricarboxylate transporter family receptor
RD15_RS02055	COG1024	Enoyl-CoA hydratase
RD15_RS02055	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD15_RS02060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD15_RS02065	COG0028	Belongs to the TPP enzyme family
RD15_RS02090	COG3181	Tripartite tricarboxylate transporter family receptor
RD15_RS02100	COG0697	spore germination
RD15_RS02125	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RD15_RS02130	COG0463	Glycosyl transferase, family 2
RD15_RS02145	COG0786	glutamate:sodium symporter activity
RD15_RS02155	COG2031	fatty acid transporter
RD15_RS02170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RD15_RS02175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RD15_RS02185	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RD15_RS02200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RD15_RS02210	COG1285	pathogenesis
RD15_RS02215	COG1253	flavin adenine dinucleotide binding
RD15_RS02220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD15_RS02225	COG1024	Enoyl-CoA hydratase
RD15_RS02230	COG3181	Tripartite tricarboxylate transporter family receptor
RD15_RS02235	COG0583	DNA-binding transcription factor activity
RD15_RS02240	COG1960	acyl-CoA dehydrogenase activity
RD15_RS02250	COG0183	Belongs to the thiolase family
RD15_RS02265	COG0583	DNA-binding transcription factor activity
RD15_RS02270	COG1278	Cold shock
RD15_RS02280	COG1802	Transcriptional regulator
RD15_RS02285	COG1012	belongs to the aldehyde dehydrogenase family
RD15_RS02290	COG2031	fatty acid transporter
RD15_RS02295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RD15_RS02295	COG1017	nitric oxide dioxygenase activity
RD15_RS02300	COG0251	oxidation-reduction process
RD15_RS02325	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD15_RS02335	COG0583	DNA-binding transcription factor activity
RD15_RS02340	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD15_RS02350	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
RD15_RS02355	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RD15_RS02360	COG0546	phosphoglycolate phosphatase activity
RD15_RS02370	COG1530	ribonuclease E activity
RD15_RS02395	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RD15_RS02405	COG3781	membrane
RD15_RS02410	COG1522	sequence-specific DNA binding
RD15_RS02415	COG0028	Belongs to the TPP enzyme family
RD15_RS02425	COG1012	belongs to the aldehyde dehydrogenase family
RD15_RS02430	COG1028	Short-chain dehydrogenase reductase Sdr
RD15_RS02435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD15_RS02440	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
RD15_RS02465	COG2922	Belongs to the Smg family
RD15_RS02470	COG1629	transport
RD15_RS02480	COG2358	TRAP transporter, solute receptor (TAXI family
RD15_RS02490	COG3181	Tripartite tricarboxylate transporter family receptor
RD15_RS02495	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RD15_RS02510	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RD15_RS02515	COG0183	Belongs to the thiolase family
RD15_RS02525	COG1960	acyl-CoA dehydrogenase activity
RD15_RS02545	COG1960	acyl-CoA dehydrogenase activity
RD15_RS02565	COG1304	FMN binding
RD15_RS02580	COG0154	amidase activity
RD15_RS02585	COG1414	Transcriptional regulator
RD15_RS02600	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RD15_RS02605	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RD15_RS02610	COG0594	ribonuclease P activity
RD15_RS02615	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RD15_RS02620	COG0706	membrane insertase activity
RD15_RS02630	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RD15_RS02655	COG0582	viral genome integration into host DNA
RD15_RS02690	COG3723	Recombinational DNA repair protein, rece pathway
RD15_RS02735	COG0251	oxidation-reduction process
RD15_RS02745	COG0330	HflC and HflK could
RD15_RS02750	COG3422	double-strand break repair
RD15_RS02765	COG0583	DNA-binding transcription factor activity
RD15_RS02795	COG3181	Tripartite tricarboxylate transporter family receptor
RD15_RS02800	COG0318	PFAM AMP-dependent synthetase and ligase
RD15_RS02805	COG1414	Transcriptional regulator
RD15_RS02810	COG1024	Enoyl-CoA hydratase
RD15_RS02815	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RD15_RS02835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RD15_RS02855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD15_RS02860	COG1942	4-Oxalocrotonate Tautomerase
RD15_RS02865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RD15_RS02885	COG0546	phosphoglycolate phosphatase activity
RD15_RS02895	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RD15_RS02900	COG0242	peptide deformylase activity
RD15_RS02910	COG1522	sequence-specific DNA binding
RD15_RS02915	COG0758	DNA mediated transformation
RD15_RS02930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD15_RS02935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RD15_RS02940	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RD15_RS02955	COG0583	DNA-binding transcription factor activity
RD15_RS02975	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
RD15_RS02985	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RD15_RS02985	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RD15_RS02995	COG5000	phosphorelay sensor kinase activity
RD15_RS03000	COG2204	response regulator
RD15_RS03025	COG2068	MobA-Related Protein
RD15_RS03035	COG3473	Maleate cis-trans isomerase
RD15_RS03040	COG0596	Alpha beta hydrolase
RD15_RS03045	COG2309	aminopeptidase activity
RD15_RS03050	COG1335	isochorismatase
RD15_RS03075	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD15_RS03100	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
RD15_RS03105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD15_RS03120	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
RD15_RS03125	COG2226	methyltransferase
RD15_RS03140	COG3181	Tripartite tricarboxylate transporter family receptor
RD15_RS03145	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RD15_RS03150	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
RD15_RS03155	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RD15_RS03160	COG1054	Belongs to the UPF0176 family
RD15_RS03165	COG0588	phosphoglycerate mutase activity
RD15_RS03170	COG4942	peptidase
RD15_RS03175	COG0793	Belongs to the peptidase S41A family
RD15_RS03180	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RD15_RS03205	COG3181	Tripartite tricarboxylate transporter family receptor
RD15_RS03220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RD15_RS03230	COG0411	ABC transporter
RD15_RS03235	COG0559	Belongs to the binding-protein-dependent transport system permease family
RD15_RS03240	COG0683	leucine binding
RD15_RS03260	COG0508	dehydrogenase complex catalyzes the overall conversion of
RD15_RS03265	COG1024	Enoyl-CoA hydratase
RD15_RS03270	COG0022	dehydrogenase e1 component
RD15_RS03275	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RD15_RS03295	COG1960	acyl-CoA dehydrogenase activity
RD15_RS03300	COG1024	Enoyl-CoA hydratase
RD15_RS03305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RD15_RS03325	COG1960	acyl-CoA dehydrogenase activity
RD15_RS03330	COG3181	Tripartite tricarboxylate transporter family receptor
RD15_RS03335	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD15_RS03345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RD15_RS03365	COG3181	Tripartite tricarboxylate transporter family receptor
RD15_RS03375	COG0277	FAD linked oxidase domain protein
RD15_RS03380	COG1960	acyl-CoA dehydrogenase activity
RD15_RS03385	COG1960	acyl-CoA dehydrogenase activity
RD15_RS03395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RD15_RS03410	COG2072	flavoprotein involved in K transport
RD15_RS03415	COG0604	alcohol dehydrogenase
RD15_RS03430	COG1024	Enoyl-CoA hydratase
RD15_RS03450	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RD15_RS03455	COG1522	sequence-specific DNA binding
RD15_RS03460	COG0183	Belongs to the thiolase family
RD15_RS03470	COG1960	acyl-CoA dehydrogenase activity
RD15_RS03515	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RD15_RS03520	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RD15_RS03525	COG2890	protein-(glutamine-N5) methyltransferase activity
RD15_RS03530	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
RD15_RS03540	COG3181	Tripartite tricarboxylate transporter family receptor
RD15_RS03580	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RD15_RS03585	COG1660	Displays ATPase and GTPase activities
RD15_RS03595	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RD15_RS03595	COG2010	Cytochrome c
RD15_RS03600	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
RD15_RS03610	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RD15_RS03615	COG1137	ATPase activity
RD15_RS03630	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
RD15_RS03640	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
RD15_RS03675	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RD15_RS03680	COG3568	Endonuclease Exonuclease Phosphatase
RD15_RS03685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RD15_RS03715	COG0154	amidase activity
RD15_RS03725	COG1414	Transcriptional regulator
RD15_RS03740	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD15_RS03740	COG1024	Enoyl-CoA hydratase
RD15_RS03750	COG2132	Multicopper oxidase
RD15_RS03780	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD15_RS03805	COG1024	Enoyl-CoA hydratase
RD15_RS03810	COG1024	Enoyl-CoA hydratase
RD15_RS03815	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RD15_RS03835	COG0601	transmembrane transport
RD15_RS03840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD15_RS03845	COG4608	Belongs to the ABC transporter superfamily
RD15_RS03855	COG2195	Cleaves the N-terminal amino acid of tripeptides
RD15_RS03865	COG0210	DNA helicase
RD15_RS03870	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RD15_RS03875	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
RD15_RS03885	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RD15_RS03890	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RD15_RS03895	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RD15_RS03900	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RD15_RS03905	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RD15_RS03910	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RD15_RS03920	COG0356	it plays a direct role in the translocation of protons across the membrane
RD15_RS03945	COG1024	Enoyl-CoA hydratase
RD15_RS03950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RD15_RS03955	COG3634	alkyl hydroperoxide reductase activity
RD15_RS03965	COG0037	tRNA processing
RD15_RS03975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RD15_RS03980	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RD15_RS03985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RD15_RS03990	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
RD15_RS03995	COG2967	ApaG domain
RD15_RS04000	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RD15_RS04005	COG0546	phosphoglycolate phosphatase activity
RD15_RS04015	COG0512	Glutamine amidotransferase of anthranilate synthase
RD15_RS04020	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RD15_RS04025	COG0134	indole-3-glycerol-phosphate synthase activity
RD15_RS04050	COG1960	acyl-CoA dehydrogenase activity
RD15_RS04055	COG0583	DNA-binding transcription factor activity
RD15_RS04070	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RD15_RS04075	COG0259	pyridoxamine-phosphate oxidase activity
RD15_RS04085	COG2814	Major facilitator Superfamily
RD15_RS04090	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RD15_RS04095	COG2188	Transcriptional regulator
RD15_RS04100	COG0318	PFAM AMP-dependent synthetase and ligase
RD15_RS04120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RD15_RS04130	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RD15_RS04145	COG1215	transferase activity, transferring glycosyl groups
RD15_RS04155	COG0601	transmembrane transport
RD15_RS04165	COG0488	(ABC) transporter
RD15_RS04185	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
RD15_RS04190	COG2894	cell division
RD15_RS04195	COG0850	regulation of cytokinetic process
RD15_RS04200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RD15_RS04205	COG1271	oxidase subunit
RD15_RS04240	COG2979	Protein of unknown function (DUF533)
RD15_RS04260	COG1388	LysM domain
RD15_RS04260	COG0741	lytic transglycosylase activity
RD15_RS04265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RD15_RS04270	COG2226	methyltransferase
RD15_RS04275	COG0328	RNA-DNA hybrid ribonuclease activity
RD15_RS04320	COG2030	dehydratase
RD15_RS04325	COG0183	Belongs to the thiolase family
RD15_RS04370	COG1960	acyl-CoA dehydrogenase activity
RD15_RS04385	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD15_RS04390	COG1028	Short-chain dehydrogenase reductase Sdr
RD15_RS04405	COG2718	Belongs to the UPF0229 family
RD15_RS04410	COG2719	SpoVR family
RD15_RS04435	COG2188	Transcriptional regulator
RD15_RS04450	COG0633	Ferredoxin
RD15_RS04460	COG0829	nickel cation binding
RD15_RS04465	COG0831	urea catabolic process
RD15_RS04475	COG0832	Belongs to the urease beta subunit family
RD15_RS04480	COG0804	urea catabolic process
RD15_RS04490	COG0830	nickel cation binding
RD15_RS04495	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RD15_RS04515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD15_RS04520	COG0601	transmembrane transport
RD15_RS04525	COG0747	negative chemotaxis
RD15_RS04535	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RD15_RS04540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RD15_RS04550	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RD15_RS04560	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
RD15_RS04565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RD15_RS04570	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
RD15_RS04585	COG0438	transferase activity, transferring glycosyl groups
RD15_RS04600	COG0438	transferase activity, transferring glycosyl groups
RD15_RS04605	COG0438	transferase activity, transferring glycosyl groups
RD15_RS04610	COG0166	Belongs to the GPI family
RD15_RS04625	COG0277	FAD linked oxidase domain protein
RD15_RS04630	COG0745	RESPONSE REGULATOR receiver
RD15_RS04635	COG0642	Histidine kinase
RD15_RS04640	COG1368	sulfuric ester hydrolase activity
RD15_RS04650	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
RD15_RS04675	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RD15_RS04685	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
RD15_RS04690	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RD15_RS04700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RD15_RS04705	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RD15_RS04710	COG0193	aminoacyl-tRNA hydrolase activity
RD15_RS04720	COG0012	GTP binding
RD15_RS04725	COG0582	viral genome integration into host DNA
RD15_RS04745	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RD15_RS04785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD15_RS04795	COG0405	Gamma-glutamyltransferase
RD15_RS04810	COG1280	lysine exporter protein (LysE YggA)
RD15_RS04870	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
RD15_RS04875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RD15_RS04885	COG2096	Adenosyltransferase
RD15_RS04895	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
RD15_RS04900	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
RD15_RS04910	COG0523	cobalamin synthesis protein
RD15_RS04915	COG0735	belongs to the Fur family
RD15_RS04935	COG0803	Belongs to the bacterial solute-binding protein 9 family
RD15_RS04945	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
RD15_RS04955	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
RD15_RS04965	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RD15_RS04970	COG1560	Kdo2-lipid A biosynthetic process
RD15_RS04980	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RD15_RS04995	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
RD15_RS05000	COG1950	PFAM Membrane protein of
RD15_RS05015	COG0583	DNA-binding transcription factor activity
RD15_RS05025	COG0477	Major facilitator Superfamily
RD15_RS05040	COG0617	tRNA 3'-terminal CCA addition
RD15_RS05050	COG0513	Belongs to the DEAD box helicase family
RD15_RS05055	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RD15_RS05065	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RD15_RS05070	COG2084	Dehydrogenase
RD15_RS05120	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RD15_RS05125	COG0129	dihydroxy-acid dehydratase activity
RD15_RS05130	COG4654	Cytochrome c, class I
RD15_RS05135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RD15_RS05185	COG1473	amidohydrolase
RD15_RS05190	COG0418	dihydroorotase activity
RD15_RS05195	COG0488	(ABC) transporter
RD15_RS05205	COG2001	Belongs to the MraZ family
RD15_RS05210	COG0275	rRNA processing
RD15_RS05215	COG3116	cell division
RD15_RS05225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RD15_RS05230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RD15_RS05235	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RD15_RS05245	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RD15_RS05250	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RD15_RS05255	COG1181	Belongs to the D-alanine--D-alanine ligase family
RD15_RS05260	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RD15_RS05270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RD15_RS05275	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
RD15_RS05285	COG0739	heme binding
RD15_RS05290	COG0653	protein targeting
RD15_RS05310	COG1028	Short-chain dehydrogenase reductase Sdr
RD15_RS05315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD15_RS05320	COG1522	sequence-specific DNA binding
RD15_RS05340	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RD15_RS05350	COG0557	exoribonuclease II activity
RD15_RS05355	COG3150	esterase
RD15_RS05360	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RD15_RS05365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RD15_RS05370	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RD15_RS05375	COG0511	ligase activity, forming carbon-carbon bonds
RD15_RS05380	COG0439	Biotin carboxylase
RD15_RS05385	COG2264	protein methyltransferase activity
RD15_RS05395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RD15_RS05420	COG1696	Membrane protein involved in D-alanine export
RD15_RS05425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RD15_RS05460	COG1522	sequence-specific DNA binding
RD15_RS05475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RD15_RS05480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RD15_RS05480	COG1042	CoA-binding domain protein
RD15_RS05480	COG0045	succinate-CoA ligase (ADP-forming) activity
RD15_RS05490	COG1802	Transcriptional regulator
RD15_RS05495	COG3069	C4-dicarboxylate transmembrane transporter activity
RD15_RS05500	COG0513	Belongs to the DEAD box helicase family
RD15_RS05505	COG0346	lactoylglutathione lyase activity
RD15_RS05510	COG1335	isochorismatase
RD15_RS05515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD15_RS05520	COG1116	anion transmembrane transporter activity
RD15_RS05535	COG3028	Belongs to the UPF0307 family
RD15_RS05540	COG0312	modulator of DNA gyrase
RD15_RS05545	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD15_RS05550	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RD15_RS05555	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RD15_RS05560	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RD15_RS05570	COG0316	Belongs to the HesB IscA family
RD15_RS05575	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
RD15_RS05590	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RD15_RS05600	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RD15_RS05605	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RD15_RS05620	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RD15_RS05620	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RD15_RS05650	COG0583	DNA-binding transcription factor activity
RD15_RS05655	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD15_RS05690	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
RD15_RS05700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RD15_RS05705	COG1845	cytochrome c oxidase, subunit III
RD15_RS05710	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RD15_RS05715	COG0640	Transcriptional regulator
RD15_RS05735	COG3220	belongs to the UPF0276 family
RD15_RS05780	COG1666	GTP binding
RD15_RS05815	COG0312	modulator of DNA gyrase
RD15_RS05820	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RD15_RS05825	COG3064	Membrane
RD15_RS05825	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
RD15_RS05825	COG3064	Membrane
RD15_RS05825	COG3210	domain, Protein
RD15_RS05825	COG3210	domain, Protein
RD15_RS05825	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
RD15_RS05830	COG0277	FAD linked oxidase domain protein
RD15_RS05835	COG0277	FAD linked oxidase domain protein
RD15_RS05840	COG0277	FAD linked oxidase domain protein
RD15_RS05845	COG0247	lactate metabolic process
RD15_RS05850	COG2819	hydrolase of the alpha beta superfamily
RD15_RS05885	COG0583	DNA-binding transcription factor activity
RD15_RS05890	COG0482	sulfurtransferase activity
RD15_RS05895	COG0730	response to heat
RD15_RS05900	COG0625	glutathione transferase activity
RD15_RS05905	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RD15_RS05910	COG3909	cytochrome
RD15_RS05950	COG0154	amidase activity
RD15_RS05955	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD15_RS05960	COG1024	Enoyl-CoA hydratase
RD15_RS05975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD15_RS05990	COG1028	Short-chain dehydrogenase reductase Sdr
RD15_RS05995	COG1414	Transcriptional regulator
RD15_RS06005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RD15_RS06010	COG0251	oxidation-reduction process
RD15_RS06015	COG0559	Belongs to the binding-protein-dependent transport system permease family
RD15_RS06035	COG1902	pentaerythritol trinitrate reductase activity
RD15_RS06050	COG0583	DNA-binding transcription factor activity
RD15_RS06060	COG0590	tRNA wobble adenosine to inosine editing
RD15_RS06065	COG2807	transmembrane transport
RD15_RS06085	COG0154	amidase activity
RD15_RS06090	COG0307	riboflavin synthase, alpha
RD15_RS06095	COG3181	Tripartite tricarboxylate transporter family receptor
RD15_RS06100	COG1522	sequence-specific DNA binding
RD15_RS06110	COG0318	PFAM AMP-dependent synthetase and ligase
RD15_RS06120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD15_RS06140	COG1063	alcohol dehydrogenase
RD15_RS06165	COG1418	mRNA catabolic process
RD15_RS06170	COG1448	Aminotransferase
RD15_RS06175	COG0583	DNA-binding transcription factor activity
RD15_RS06185	COG0477	Major facilitator Superfamily
RD15_RS06190	COG1028	Short-chain dehydrogenase reductase Sdr
RD15_RS06205	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RD15_RS06210	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
RD15_RS06215	COG0583	DNA-binding transcription factor activity
RD15_RS06255	COG1028	Short-chain dehydrogenase reductase Sdr
RD15_RS06260	COG1309	transcriptional regulator
RD15_RS06265	COG2982	Protein involved in outer membrane biogenesis
RD15_RS06270	COG2818	Glycosylase
RD15_RS06290	COG1653	transport
RD15_RS06300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RD15_RS06305	COG3842	ATPase activity
RD15_RS06310	COG0395	ABC-type sugar transport system, permease component
RD15_RS06315	COG1175	transmembrane transport
RD15_RS06335	COG3181	Tripartite tricarboxylate transporter family receptor
RD15_RS06340	COG2186	Transcriptional regulator
RD15_RS06365	COG1454	alcohol dehydrogenase
RD15_RS06385	COG2011	ABC-type metal ion transport system permease component
RD15_RS06390	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RD15_RS06395	COG1501	Belongs to the glycosyl hydrolase 31 family
RD15_RS06420	COG0318	PFAM AMP-dependent synthetase and ligase
RD15_RS06425	COG1473	amidohydrolase
RD15_RS06435	COG2855	membrane
RD15_RS06445	COG2239	Acts as a magnesium transporter
RD15_RS06465	COG3181	Tripartite tricarboxylate transporter family receptor
RD15_RS06475	COG1722	exodeoxyribonuclease VII activity
RD15_RS06480	COG0142	geranyltranstransferase activity
RD15_RS06485	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RD15_RS06490	COG1469	GTP cyclohydrolase I activity
RD15_RS06495	COG0360	Binds together with S18 to 16S ribosomal RNA
RD15_RS06500	COG2965	DNA replication, synthesis of RNA primer
RD15_RS06505	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RD15_RS06510	COG0359	binds to the 23S rRNA
RD15_RS06520	COG0305	Participates in initiation and elongation during chromosome replication
RD15_RS06530	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RD15_RS06535	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
RD15_RS06540	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RD15_RS06545	COG3737	Protein of unknown function (DUF498/DUF598)
RD15_RS06550	COG0436	Aminotransferase
RD15_RS06575	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RD15_RS06605	COG0268	Binds directly to 16S ribosomal RNA
RD15_RS06615	COG0728	peptidoglycan biosynthetic process
RD15_RS06625	COG0563	adenylate kinase activity
RD15_RS06630	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
RD15_RS06635	COG2835	tetraacyldisaccharide 4'-kinase activity
RD15_RS06640	COG1663	tetraacyldisaccharide 4'-kinase activity
RD15_RS06645	COG0848	biopolymer transport protein
RD15_RS06650	COG0811	peptide transport
RD15_RS06660	COG1570	exodeoxyribonuclease VII activity
RD15_RS06665	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RD15_RS06670	COG0038	chloride channel
RD15_RS06675	COG0183	Belongs to the thiolase family
RD15_RS06685	COG1278	Cold shock
RD15_RS06690	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RD15_RS06700	COG4953	penicillin-binding protein 1C
RD15_RS06705	COG0542	response to heat
RD15_RS06710	COG2995	paraquat-inducible protein a
RD15_RS06715	COG3008	intermembrane lipid transfer
RD15_RS06715	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RD15_RS06725	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RD15_RS06725	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RD15_RS06725	COG0506	proline dehydrogenase activity
RD15_RS06760	COG2271	Major facilitator Superfamily
RD15_RS06765	COG1309	transcriptional regulator
RD15_RS06775	COG3468	outer membrane autotransporter barrel domain protein
RD15_RS06805	COG0477	Major facilitator Superfamily
RD15_RS06815	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RD15_RS06820	COG1845	cytochrome c oxidase, subunit III
RD15_RS06825	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RD15_RS06835	COG1028	Short-chain dehydrogenase reductase Sdr
RD15_RS06850	COG0789	Transcriptional regulator
RD15_RS06875	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RD15_RS06880	COG0697	spore germination
RD15_RS06890	COG0678	peroxiredoxin activity
RD15_RS06900	COG0412	Dienelactone hydrolase
RD15_RS06910	COG0315	cyclic pyranopterin monophosphate synthase activity
RD15_RS06925	COG0521	Mo-molybdopterin cofactor biosynthetic process
RD15_RS06930	COG0303	'Molybdopterin
RD15_RS06935	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RD15_RS06955	COG0165	Argininosuccinate lyase
RD15_RS06960	COG0668	transmembrane transport
RD15_RS07005	COG0747	negative chemotaxis
RD15_RS07010	COG0601	transmembrane transport
RD15_RS07015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD15_RS07020	COG1162	GTPase activity
RD15_RS07025	COG0501	Belongs to the peptidase M48B family
RD15_RS07030	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
RD15_RS07040	COG3327	negative regulation of DNA-templated transcription, initiation
RD15_RS07045	COG3396	Phenylacetate-CoA oxygenase
RD15_RS07050	COG3460	Phenylacetate-CoA oxygenase
RD15_RS07055	COG3396	Phenylacetate-CoA oxygenase
RD15_RS07060	COG2151	metal-sulfur cluster biosynthetic enzyme
RD15_RS07065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RD15_RS07075	COG1012	belongs to the aldehyde dehydrogenase family
RD15_RS07080	COG1024	Enoyl-CoA hydratase
RD15_RS07085	COG2050	protein possibly involved in aromatic compounds catabolism
RD15_RS07095	COG3539	Fimbrial protein
RD15_RS07105	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD15_RS07110	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD15_RS07110	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD15_RS07115	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD15_RS07120	COG0047	phosphoribosylformylglycinamidine synthase activity
RD15_RS07120	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RD15_RS07125	COG3064	Membrane
RD15_RS07125	COG3210	domain, Protein
RD15_RS07125	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
RD15_RS07150	COG0235	Class ii aldolase
RD15_RS07155	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD15_RS07160	COG0720	synthase
RD15_RS07165	COG0602	queuosine metabolic process
RD15_RS07190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RD15_RS07225	COG3181	Tripartite tricarboxylate transporter family receptor
RD15_RS07255	COG3842	ATPase activity
RD15_RS07265	COG0395	ABC-type sugar transport system, permease component
RD15_RS07295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD15_RS07300	COG0420	3'-5' exonuclease activity
RD15_RS07325	COG2197	response regulator
RD15_RS07350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RD15_RS07350	COG0519	Catalyzes the synthesis of GMP from XMP
RD15_RS07360	COG3550	peptidyl-serine autophosphorylation
RD15_RS07370	COG0477	Major facilitator Superfamily
RD15_RS07385	COG1228	amidohydrolase
RD15_RS07395	COG1116	anion transmembrane transporter activity
RD15_RS07400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD15_RS07425	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
RD15_RS07445	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
RD15_RS07475	COG2814	Major facilitator Superfamily
RD15_RS07490	COG1280	lysine exporter protein (LysE YggA)
RD15_RS07510	COG0747	negative chemotaxis
RD15_RS07515	COG0601	transmembrane transport
RD15_RS07520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD15_RS07525	COG4172	Belongs to the ABC transporter superfamily
RD15_RS07530	COG1609	Transcriptional regulator
RD15_RS07555	COG0586	Pfam SNARE associated Golgi protein
RD15_RS07565	COG0500	methyltransferase
RD15_RS07580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RD15_RS07590	COG0756	dUTP diphosphatase activity
RD15_RS07600	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RD15_RS07605	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RD15_RS07610	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RD15_RS07615	COG0072	phenylalanine-tRNA ligase activity
RD15_RS07615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RD15_RS07620	COG0776	regulation of translation
RD15_RS07690	COG0540	Belongs to the ATCase OTCase family
RD15_RS07695	COG2974	May be involved in recombination
RD15_RS07705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD15_RS07710	COG0583	DNA-binding transcription factor activity
RD15_RS07730	COG1028	Short-chain dehydrogenase reductase Sdr
RD15_RS07745	COG3842	ATPase activity
RD15_RS07750	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD15_RS07750	COG1024	Enoyl-CoA hydratase
RD15_RS07770	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RD15_RS07775	COG2137	regulation of response to DNA damage stimulus
RD15_RS07785	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
RD15_RS07795	COG0045	succinate-CoA ligase (ADP-forming) activity
RD15_RS07800	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RD15_RS07805	COG0861	Integral membrane protein TerC family
RD15_RS07810	COG0861	Integral membrane protein TerC family
RD15_RS07815	COG0181	hydroxymethylbilane synthase activity
RD15_RS07875	COG4964	Belongs to the GSP D family
RD15_RS07905	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RD15_RS07915	COG0583	DNA-binding transcription factor activity
RD15_RS07925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD15_RS07930	COG4311	Sarcosine oxidase, delta subunit
RD15_RS07935	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RD15_RS07935	COG0446	pyridine nucleotide-disulphide oxidoreductase
RD15_RS07970	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RD15_RS07975	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RD15_RS07980	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RD15_RS07985	COG0735	belongs to the Fur family
RD15_RS07990	COG0497	DNA recombination
RD15_RS07995	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RD15_RS08000	COG1420	regulation of RNA biosynthetic process
RD15_RS08005	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RD15_RS08015	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RD15_RS08025	COG0443	Heat shock 70 kDa protein
RD15_RS08035	COG0612	Peptidase, M16
RD15_RS08055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RD15_RS08100	COG0745	RESPONSE REGULATOR receiver
RD15_RS08105	COG2205	protein histidine kinase activity
RD15_RS08110	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
RD15_RS08115	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
RD15_RS08120	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
RD15_RS08130	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RD15_RS08145	COG1193	negative regulation of DNA recombination
RD15_RS08150	COG0492	ferredoxin-NADP+ reductase activity
RD15_RS08155	COG1674	ftsk spoiiie
RD15_RS08160	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
RD15_RS08165	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RD15_RS08170	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RD15_RS08195	COG3706	GGDEF domain
RD15_RS08215	COG2814	Major facilitator Superfamily
RD15_RS08245	COG3486	L-lysine 6-monooxygenase (NADPH) activity
RD15_RS08260	COG1028	Short-chain dehydrogenase reductase Sdr
RD15_RS08270	COG3022	response to hydroperoxide
RD15_RS08280	COG1289	transmembrane transporter activity
RD15_RS08285	COG3023	N-Acetylmuramoyl-L-alanine amidase
RD15_RS08295	COG0424	maF-like protein
RD15_RS08300	COG1399	metal-binding, possibly nucleic acid-binding protein
RD15_RS08305	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RD15_RS08310	COG0416	fatty acid biosynthetic process
RD15_RS08315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RD15_RS08330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RD15_RS08335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RD15_RS08360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RD15_RS08365	COG0481	GTPase activity
RD15_RS08370	COG0681	Belongs to the peptidase S26 family
RD15_RS08375	COG0571	ribonuclease III activity
RD15_RS08380	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RD15_RS08385	COG1381	Involved in DNA repair and RecF pathway recombination
RD15_RS08395	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RD15_RS08410	COG3181	Tripartite tricarboxylate transporter family receptor
RD15_RS08415	COG0670	Belongs to the BI1 family
RD15_RS08430	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RD15_RS08440	COG0583	DNA-binding transcription factor activity
RD15_RS08455	COG0583	DNA-binding transcription factor activity
RD15_RS08470	COG0791	NLP P60 protein
RD15_RS08475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RD15_RS08480	COG3193	protein, possibly involved in utilization of glycolate and propanediol
RD15_RS08490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RD15_RS08495	COG0697	spore germination
RD15_RS08500	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
RD15_RS08515	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RD15_RS08545	COG1446	asparaginase
RD15_RS08550	COG4172	Belongs to the ABC transporter superfamily
RD15_RS08555	COG0747	negative chemotaxis
RD15_RS08565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD15_RS08590	COG0504	CTP synthase activity
RD15_RS08595	COG2877	3-deoxy-8-phosphooctulonate synthase activity
RD15_RS08605	COG0148	phosphopyruvate hydratase activity
RD15_RS08610	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
RD15_RS08640	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
RD15_RS08650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RD15_RS08675	COG1981	membrane
RD15_RS08705	COG0039	L-malate dehydrogenase activity
RD15_RS08710	COG2188	Transcriptional regulator
RD15_RS08715	COG2009	succinate dehydrogenase
RD15_RS08720	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
RD15_RS08725	COG1053	succinate dehydrogenase
RD15_RS08730	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RD15_RS08735	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
RD15_RS08740	COG0372	Belongs to the citrate synthase family
RD15_RS08760	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD15_RS08760	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD15_RS08770	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD15_RS08775	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
RD15_RS08790	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RD15_RS08795	COG3842	ATPase activity
RD15_RS08800	COG1176	ABC-type spermidine putrescine transport system, permease component I
RD15_RS08805	COG1177	transmembrane transport
RD15_RS08830	COG1960	acyl-CoA dehydrogenase activity
RD15_RS08835	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
RD15_RS08840	COG0704	Plays a role in the regulation of phosphate uptake
RD15_RS08850	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
RD15_RS08855	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RD15_RS08855	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RD15_RS08860	COG1643	Atp-dependent helicase
RD15_RS08875	COG0438	transferase activity, transferring glycosyl groups
RD15_RS08880	COG0726	polysaccharide deacetylase
RD15_RS08885	COG0463	Glycosyl transferase, family 2
RD15_RS08890	COG0438	transferase activity, transferring glycosyl groups
RD15_RS08895	COG2194	sulfuric ester hydrolase activity
RD15_RS08920	COG0859	PFAM glycosyl transferase family 9
RD15_RS08925	COG1132	(ABC) transporter
RD15_RS08940	COG0077	Prephenate dehydratase
RD15_RS08945	COG1530	ribonuclease E activity
RD15_RS08985	COG3468	outer membrane autotransporter barrel domain protein
RD15_RS08990	COG0424	maF-like protein
RD15_RS08995	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RD15_RS09000	COG0799	negative regulation of ribosome biogenesis
RD15_RS09005	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RD15_RS09010	COG0408	coproporphyrinogen oxidase activity
RD15_RS09015	COG0151	Belongs to the GarS family
RD15_RS09020	COG0217	transcriptional regulatory protein
RD15_RS09025	COG0433	COG0433 Predicted ATPase
RD15_RS09030	COG1115	amino acid carrier protein
RD15_RS09035	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RD15_RS09045	COG1012	belongs to the aldehyde dehydrogenase family
RD15_RS09070	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RD15_RS09085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD15_RS09095	COG0747	negative chemotaxis
RD15_RS09105	COG0473	3-isopropylmalate dehydrogenase activity
RD15_RS09110	COG2814	Major facilitator Superfamily
RD15_RS09115	COG1566	PFAM secretion protein HlyD family protein
RD15_RS09125	COG1846	Transcriptional regulator
RD15_RS09135	COG0697	spore germination
RD15_RS09145	COG0501	Belongs to the peptidase M48B family
RD15_RS09165	COG0583	DNA-binding transcription factor activity
RD15_RS09170	COG3842	ATPase activity
RD15_RS09175	COG1178	ABC-type Fe3 transport system permease component
RD15_RS09180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RD15_RS09185	COG1840	ABC-type Fe3 transport system, periplasmic component
RD15_RS09190	COG0492	ferredoxin-NADP+ reductase activity
RD15_RS09210	COG2233	PERMEase
RD15_RS09215	COG0840	transmembrane signaling receptor activity
RD15_RS09220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RD15_RS09250	COG4789	Type iii secretion
RD15_RS09315	COG4669	(LipO)protein
RD15_RS09350	COG4790	Type iii secretion
RD15_RS09355	COG4794	Type iii secretion
RD15_RS09360	COG4791	protein targeting
RD15_RS09365	COG4792	protein secretion
RD15_RS09380	COG1595	DNA-templated transcription, initiation
RD15_RS09405	COG2208	phosphoserine phosphatase activity
RD15_RS09405	COG2770	Histidine kinase
RD15_RS09415	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RD15_RS09420	COG2172	sigma factor antagonist activity
RD15_RS09425	COG1366	Belongs to the anti-sigma-factor antagonist family
RD15_RS09430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RD15_RS09460	COG2358	TRAP transporter, solute receptor (TAXI family
RD15_RS09465	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RD15_RS09495	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RD15_RS09495	COG1017	nitric oxide dioxygenase activity
RD15_RS09500	COG1959	2 iron, 2 sulfur cluster binding
RD15_RS09505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD15_RS09530	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RD15_RS09535	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RD15_RS09540	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RD15_RS09545	COG0084	hydrolase, TatD family'
RD15_RS09560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD15_RS09570	COG1126	abc transporter atp-binding protein
RD15_RS09575	COG0010	Belongs to the arginase family
RD15_RS09580	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RD15_RS09585	COG1012	belongs to the aldehyde dehydrogenase family
RD15_RS09595	COG0028	Belongs to the TPP enzyme family
RD15_RS09605	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD15_RS09605	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD15_RS09615	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD15_RS09630	COG3189	MarR family transcriptional regulator
RD15_RS09655	COG4336	lyase activity
RD15_RS09665	COG2205	protein histidine kinase activity
RD15_RS09665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD15_RS09670	COG2197	response regulator
RD15_RS09675	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
RD15_RS09675	COG3064	Membrane
RD15_RS09675	COG3210	domain, Protein
RD15_RS09685	COG3121	Chaperone
RD15_RS09690	COG3188	usher protein
RD15_RS09695	COG3539	Fimbrial protein
RD15_RS09700	COG2831	hemolysin activation secretion protein
RD15_RS09715	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD15_RS09740	COG0583	DNA-binding transcription factor activity
RD15_RS09765	COG0668	transmembrane transport
RD15_RS09785	COG0483	inositol monophosphate 1-phosphatase activity
RD15_RS09790	COG1253	flavin adenine dinucleotide binding
RD15_RS09795	COG1968	undecaprenyl-diphosphatase activity
RD15_RS09800	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RD15_RS09815	COG0215	cysteine-tRNA ligase activity
RD15_RS09825	COG0825	malonyl-CoA metabolic process
RD15_RS09835	COG0037	tRNA processing
RD15_RS09840	COG0527	aspartate kinase activity
RD15_RS09865	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD15_RS09870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD15_RS09870	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD15_RS09885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RD15_RS09890	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
RD15_RS09895	COG1028	Short-chain dehydrogenase reductase Sdr
RD15_RS09905	COG0583	DNA-binding transcription factor activity
RD15_RS09935	COG3842	ATPase activity
RD15_RS09945	COG1902	pentaerythritol trinitrate reductase activity
RD15_RS09945	COG0446	pyridine nucleotide-disulphide oxidoreductase
RD15_RS09950	COG1414	Transcriptional regulator
RD15_RS09955	COG1832	CoA-binding protein
RD15_RS09965	COG0251	oxidation-reduction process
RD15_RS09990	COG1902	pentaerythritol trinitrate reductase activity
RD15_RS10000	COG1215	transferase activity, transferring glycosyl groups
RD15_RS10005	COG0726	polysaccharide deacetylase
RD15_RS10005	COG1649	PFAM Uncharacterised BCR, COG1649
RD15_RS10025	COG1846	Transcriptional regulator
RD15_RS10055	COG2010	Cytochrome c
RD15_RS10055	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RD15_RS10060	COG2080	2 iron, 2 sulfur cluster binding
RD15_RS10065	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RD15_RS10070	COG3473	Maleate cis-trans isomerase
RD15_RS10075	COG0596	Alpha beta hydrolase
RD15_RS10080	COG2309	aminopeptidase activity
RD15_RS10085	COG1335	isochorismatase
RD15_RS10100	COG1017	nitric oxide dioxygenase activity
RD15_RS10100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RD15_RS10115	COG3181	Tripartite tricarboxylate transporter family receptor
RD15_RS10140	COG0166	Belongs to the GPI family
RD15_RS10145	COG1045	serine acetyltransferase
RD15_RS10155	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RD15_RS10160	COG0483	inositol monophosphate 1-phosphatase activity
RD15_RS10165	COG1012	belongs to the aldehyde dehydrogenase family
RD15_RS10170	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RD15_RS10185	COG0210	DNA helicase
RD15_RS10190	COG0598	Magnesium transport protein CorA
RD15_RS10200	COG0747	negative chemotaxis
RD15_RS10205	COG0601	transmembrane transport
RD15_RS10210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD15_RS10215	COG4172	Belongs to the ABC transporter superfamily
RD15_RS10220	COG1846	Transcriptional regulator
RD15_RS10265	COG4964	Belongs to the GSP D family
RD15_RS10305	COG2204	response regulator
RD15_RS10320	COG1595	DNA-templated transcription, initiation
RD15_RS10330	COG3474	cytochrome
RD15_RS10335	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RD15_RS10350	COG3384	dioxygenase
RD15_RS10355	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RD15_RS10380	COG2885	chlorophyll binding
RD15_RS10415	COG0697	spore germination
RD15_RS10420	COG0730	response to heat
RD15_RS10435	COG0583	DNA-binding transcription factor activity
RD15_RS10440	COG0427	acetyl-CoA hydrolase
RD15_RS10495	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD15_RS10500	COG0154	amidase activity
RD15_RS10510	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RD15_RS10525	COG0495	leucyl-tRNA aminoacylation
RD15_RS10530	COG2814	Major facilitator Superfamily
RD15_RS10555	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RD15_RS10560	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RD15_RS10565	COG2814	Major facilitator Superfamily
RD15_RS10570	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RD15_RS10585	COG4176	ABC-type proline glycine betaine transport system permease component
RD15_RS10595	COG1942	4-Oxalocrotonate Tautomerase
RD15_RS10600	COG0183	Belongs to the thiolase family
RD15_RS10610	COG1802	Transcriptional regulator
RD15_RS10620	COG1024	Enoyl-CoA hydratase
RD15_RS10635	COG2032	superoxide dismutase activity
RD15_RS10650	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RD15_RS10675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RD15_RS10680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RD15_RS10690	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
RD15_RS10695	COG0736	holo-[acyl-carrier-protein] synthase activity
RD15_RS10700	COG1472	Belongs to the glycosyl hydrolase 3 family
RD15_RS10705	COG0322	excinuclease ABC activity
RD15_RS10710	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RD15_RS10725	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RD15_RS10725	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RD15_RS10730	COG2224	Isocitrate lyase
RD15_RS10750	COG0559	Belongs to the binding-protein-dependent transport system permease family
RD15_RS10760	COG4638	Rieske (2fe-2S)
RD15_RS10770	COG1024	Enoyl-CoA hydratase
RD15_RS10780	COG0633	Ferredoxin
RD15_RS10785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD15_RS10800	COG0183	Belongs to the thiolase family
RD15_RS10810	COG4692	amylo-alpha-1,6-glucosidase activity
RD15_RS10815	COG0583	DNA-binding transcription factor activity
RD15_RS10840	COG2346	COG2346, Truncated hemoglobins
RD15_RS10965	COG2207	Transcriptional regulator
RD15_RS11010	COG1132	(ABC) transporter
RD15_RS11035	COG0659	secondary active sulfate transmembrane transporter activity
RD15_RS11065	COG2169	Transcriptional regulator
RD15_RS11070	COG5507	3-demethylubiquinone-9 3-methyltransferase
RD15_RS11075	COG0384	phenazine biosynthesis protein PhzF
RD15_RS11080	COG0583	DNA-binding transcription factor activity
RD15_RS11085	COG2733	membrane
RD15_RS11100	COG1012	belongs to the aldehyde dehydrogenase family
RD15_RS11105	COG3284	Transcriptional regulator
RD15_RS11115	COG1346	cytolysis
RD15_RS11120	COG1380	Effector of murein hydrolase LrgA
RD15_RS11125	COG4106	trans-aconitate 2-methyltransferase activity
RD15_RS11125	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RD15_RS11135	COG0156	8-amino-7-oxononanoate synthase activity
RD15_RS11205	COG1131	(ABC) transporter
RD15_RS11210	COG0842	Transport permease protein
RD15_RS11215	COG0628	permease
RD15_RS11240	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RD15_RS11250	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RD15_RS11255	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
RD15_RS11260	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RD15_RS11265	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
RD15_RS11270	COG0330	HflC and HflK could
RD15_RS11275	COG0330	HflC and HflK could
RD15_RS11280	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RD15_RS11285	COG1923	regulation of RNA biosynthetic process
RD15_RS11290	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RD15_RS11295	COG1160	GTP binding
RD15_RS11300	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RD15_RS11305	COG2976	Protein conserved in bacteria
RD15_RS11310	COG0124	histidyl-tRNA synthetase
RD15_RS11315	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RD15_RS11325	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RD15_RS11330	COG0105	UTP biosynthetic process
RD15_RS11335	COG0525	valine-tRNA ligase activity
RD15_RS11350	COG0642	Histidine kinase
RD15_RS11370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RD15_RS11375	COG0336	Belongs to the RNA methyltransferase TrmD family
RD15_RS11380	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RD15_RS11385	COG0228	four-way junction DNA binding
RD15_RS11395	COG0425	Belongs to the sulfur carrier protein TusA family
RD15_RS11400	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RD15_RS11445	COG0154	amidase activity
RD15_RS11450	COG4172	Belongs to the ABC transporter superfamily
RD15_RS11455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD15_RS11460	COG0601	transmembrane transport
RD15_RS11465	COG0747	negative chemotaxis
RD15_RS11490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD15_RS11500	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
RD15_RS11515	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RD15_RS11520	COG3395	kinase activity
RD15_RS11535	COG1024	Enoyl-CoA hydratase
RD15_RS11555	COG0633	Ferredoxin
RD15_RS11560	COG0443	Heat shock 70 kDa protein
RD15_RS11565	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RD15_RS11570	COG0316	Belongs to the HesB IscA family
RD15_RS11575	COG0822	iron-sulfur transferase activity
RD15_RS11580	COG1104	cysteine desulfurase activity
RD15_RS11590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RD15_RS11595	COG0556	nucleotide-excision repair
RD15_RS11605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RD15_RS11610	COG3468	outer membrane autotransporter barrel domain protein
RD15_RS11640	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RD15_RS11655	COG1960	acyl-CoA dehydrogenase activity
RD15_RS11660	COG1028	Short-chain dehydrogenase reductase Sdr
RD15_RS11665	COG0183	Belongs to the thiolase family
RD15_RS11675	COG1024	Enoyl-CoA hydratase
RD15_RS11690	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD15_RS11695	COG0583	DNA-binding transcription factor activity
RD15_RS11700	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RD15_RS11705	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RD15_RS11710	COG0740	serine-type endopeptidase activity
RD15_RS11715	COG0544	peptidyl-prolyl cis-trans isomerase activity
RD15_RS11725	COG1278	Cold shock
RD15_RS11735	COG1278	Cold shock
RD15_RS11770	COG2171	N-acyltransferase activity
RD15_RS11775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RD15_RS11780	COG2890	protein-(glutamine-N5) methyltransferase activity
RD15_RS11785	COG0488	(ABC) transporter
RD15_RS11790	COG4771	TonB-dependent receptor
RD15_RS11795	COG0210	DNA helicase
RD15_RS11820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RD15_RS11820	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RD15_RS11825	COG0196	riboflavin kinase activity
RD15_RS11830	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RD15_RS11835	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RD15_RS11840	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RD15_RS11850	COG1522	sequence-specific DNA binding
RD15_RS11865	COG2951	lytic endotransglycosylase activity
RD15_RS11870	COG2833	Protein of unknown function (DUF455)
RD15_RS11890	COG0189	ligase activity
RD15_RS11890	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RD15_RS11895	COG1181	Belongs to the D-alanine--D-alanine ligase family
RD15_RS11895	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RD15_RS11900	COG3237	CsbD-like
RD15_RS11910	COG2823	Periplasmic or secreted lipoprotein
RD15_RS11920	COG4181	ATPase activity
RD15_RS11930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RD15_RS11935	COG0584	glycerophosphoryl diester phosphodiesterase
RD15_RS11940	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
RD15_RS11950	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RD15_RS11950	COG0678	peroxiredoxin activity
RD15_RS11960	COG0789	Transcriptional regulator
RD15_RS11965	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RD15_RS11995	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
RD15_RS12000	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RD15_RS12010	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RD15_RS12015	COG2252	PERMEase
RD15_RS12025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RD15_RS12060	COG0488	(ABC) transporter
RD15_RS12065	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD15_RS12080	COG1024	Enoyl-CoA hydratase
RD15_RS12085	COG1619	proteins homologs of microcin C7 resistance protein MccF
RD15_RS12090	COG0590	tRNA wobble adenosine to inosine editing
RD15_RS12115	COG2212	antiporter activity
RD15_RS12120	COG1863	multisubunit Na H antiporter MnhE subunit
RD15_RS12125	COG0651	ATP synthesis coupled electron transport
RD15_RS12130	COG1006	Multisubunit Na H antiporter MnhC subunit
RD15_RS12135	COG2111	Na H antiporter
RD15_RS12135	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RD15_RS12140	COG3181	Tripartite tricarboxylate transporter family receptor
RD15_RS12155	COG0583	DNA-binding transcription factor activity
RD15_RS12160	COG1028	Short-chain dehydrogenase reductase Sdr
RD15_RS12190	COG0431	NADPH-dependent FMN reductase
RD15_RS12235	COG1028	Short-chain dehydrogenase reductase Sdr
RD15_RS12240	COG0179	Fumarylacetoacetate (FAA) hydrolase
RD15_RS12270	COG0625	glutathione transferase activity
RD15_RS12275	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
RD15_RS12280	COG2944	sequence-specific DNA binding
RD15_RS12290	COG2197	response regulator
RD15_RS12310	COG0300	oxidoreductase activity
RD15_RS12355	COG0861	Integral membrane protein TerC family
RD15_RS12360	COG1028	Short-chain dehydrogenase reductase Sdr
RD15_RS12380	COG0714	Associated with various cellular activities
RD15_RS12410	COG3119	arylsulfatase activity
RD15_RS12440	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
RD15_RS12455	COG0438	transferase activity, transferring glycosyl groups
RD15_RS12490	COG0783	Belongs to the Dps family
RD15_RS12505	COG0583	DNA-binding transcription factor activity
RD15_RS12510	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RD15_RS12525	COG0656	L-ascorbic acid biosynthetic process
RD15_RS12535	COG0583	DNA-binding transcription factor activity
RD15_RS12545	COG1840	ABC-type Fe3 transport system, periplasmic component
RD15_RS12550	COG1178	ABC-type Fe3 transport system permease component
RD15_RS12555	COG3842	ATPase activity
RD15_RS12565	COG1741	Belongs to the pirin family
RD15_RS12570	COG1741	Belongs to the pirin family
RD15_RS12575	COG0583	DNA-binding transcription factor activity
RD15_RS12580	COG2204	response regulator
RD15_RS12590	COG0174	glutamine synthetase
RD15_RS12595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RD15_RS12605	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RD15_RS12610	COG2199	diguanylate cyclase activity
RD15_RS12610	COG2200	EAL domain
RD15_RS12635	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RD15_RS12640	COG1561	YicC-like family, N-terminal region
RD15_RS12660	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RD15_RS12665	COG0791	NLP P60 protein
RD15_RS12670	COG1028	Short-chain dehydrogenase reductase Sdr
RD15_RS12675	COG2863	cytochrome
RD15_RS12680	COG3258	Cytochrome c
RD15_RS12685	COG0194	GDP metabolic process
RD15_RS12690	COG1758	RNA polymerase activity
RD15_RS12695	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RD15_RS12700	COG1126	abc transporter atp-binding protein
RD15_RS12705	COG0765	amino acid transport
RD15_RS12710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD15_RS12725	COG1994	Peptidase M50
RD15_RS12730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RD15_RS12735	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
RD15_RS12740	COG3539	Fimbrial protein
RD15_RS12745	COG2850	peptidyl-arginine hydroxylation
RD15_RS12750	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RD15_RS12755	COG3360	Dodecin
RD15_RS12795	COG0009	L-threonylcarbamoyladenylate synthase
RD15_RS12800	COG2321	neutral zinc metallopeptidase
RD15_RS12820	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RD15_RS12825	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RD15_RS12830	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RD15_RS12840	COG1074	ATP-dependent DNA helicase activity
RD15_RS12850	COG2814	Major facilitator Superfamily
RD15_RS12860	COG1686	Belongs to the peptidase S11 family
RD15_RS12875	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
RD15_RS12880	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RD15_RS12885	COG4974	Belongs to the 'phage' integrase family
RD15_RS12890	COG0583	DNA-binding transcription factor activity
RD15_RS12895	COG0028	Belongs to the TPP enzyme family
RD15_RS12910	COG0028	Belongs to the TPP enzyme family
RD15_RS12915	COG1126	abc transporter atp-binding protein
RD15_RS12920	COG0765	amino acid transport
RD15_RS12935	COG1414	Transcriptional regulator
RD15_RS12940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD15_RS12945	COG0009	L-threonylcarbamoyladenylate synthase
RD15_RS12950	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RD15_RS12955	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RD15_RS12960	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
RD15_RS12965	COG2944	sequence-specific DNA binding
RD15_RS12975	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RD15_RS13030	COG1126	abc transporter atp-binding protein
RD15_RS13035	COG0765	amino acid transport
RD15_RS13040	COG0765	amino acid transport
RD15_RS13045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD15_RS13055	COG2423	ornithine cyclodeaminase activity
RD15_RS13065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RD15_RS13070	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RD15_RS13080	COG0189	ligase activity
RD15_RS13085	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RD15_RS13090	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RD15_RS13095	COG2197	response regulator
RD15_RS13105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RD15_RS13130	COG0135	phosphoribosylanthranilate isomerase activity
RD15_RS13145	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD15_RS13150	COG0101	tRNA pseudouridine synthase activity
RD15_RS13160	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RD15_RS13165	COG0473	3-isopropylmalate dehydrogenase activity
RD15_RS13170	COG0066	3-isopropylmalate dehydratase activity
RD15_RS13175	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RD15_RS13185	COG1122	ATPase activity
RD15_RS13215	COG0437	4 iron, 4 sulfur cluster binding
RD15_RS13220	COG3383	formate dehydrogenase (NAD+) activity
RD15_RS13220	COG0243	molybdopterin cofactor binding
RD15_RS13250	COG0489	protein tyrosine kinase activity
RD15_RS13255	COG0746	molybdenum cofactor guanylyltransferase activity
RD15_RS13260	COG0303	'Molybdopterin
RD15_RS13265	COG1763	Mo-molybdopterin cofactor biosynthetic process
RD15_RS13275	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RD15_RS13280	COG5001	Diguanylate cyclase
RD15_RS13300	COG3842	ATPase activity
RD15_RS13310	COG0406	alpha-ribazole phosphatase activity
RD15_RS13320	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RD15_RS13325	COG0505	Belongs to the CarA family
RD15_RS13330	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RD15_RS13360	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
RD15_RS13365	COG1960	acyl-CoA dehydrogenase activity
RD15_RS13375	COG2867	negative regulation of translational initiation
RD15_RS13380	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RD15_RS13385	COG3706	GGDEF domain
RD15_RS13390	COG0330	HflC and HflK could
RD15_RS13405	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RD15_RS13405	COG0519	Catalyzes the synthesis of GMP from XMP
RD15_RS13415	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
RD15_RS13420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RD15_RS13425	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RD15_RS13430	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RD15_RS13440	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RD15_RS13445	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RD15_RS13450	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
RD15_RS13455	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RD15_RS13460	COG0750	zinc metalloprotease
RD15_RS13465	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RD15_RS13475	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RD15_RS13480	COG0233	cytoplasmic translational termination
RD15_RS13485	COG0528	UMP kinase activity
RD15_RS13490	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RD15_RS13495	COG0052	Belongs to the universal ribosomal protein uS2 family
RD15_RS13500	COG0024	Methionine aminopeptidase
RD15_RS13505	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
RD15_RS13535	COG0285	dihydrofolate synthase activity
RD15_RS13570	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RD15_RS13580	COG1677	Flagellar hook-basal body complex protein FliE
RD15_RS13590	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RD15_RS13600	COG1157	protein secretion by the type III secretion system
RD15_RS13625	COG1580	Controls the rotational direction of flagella during chemotaxis
RD15_RS13645	COG1338	Plays a role in the flagellum-specific transport system
RD15_RS13665	COG0840	transmembrane signaling receptor activity
RD15_RS13670	COG0840	transmembrane signaling receptor activity
RD15_RS13675	COG0840	transmembrane signaling receptor activity
RD15_RS13685	COG1256	bacterial-type flagellum assembly
RD15_RS13695	COG1706	bacterial-type flagellum-dependent cell motility
RD15_RS13700	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
RD15_RS13715	COG1749	Flagellar hook protein flgE
RD15_RS13725	COG1558	bacterial-type flagellum-dependent cell motility
RD15_RS13730	COG1815	bacterial-type flagellum-dependent cell motility
RD15_RS13770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD15_RS13775	COG0765	amino acid transport
RD15_RS13780	COG1126	abc transporter atp-binding protein
RD15_RS13795	COG4948	Mandelate Racemase Muconate Lactonizing
RD15_RS13800	COG3181	Tripartite tricarboxylate transporter family receptor
RD15_RS13810	COG0066	3-isopropylmalate dehydratase activity
RD15_RS13825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD15_RS13835	COG3181	Tripartite tricarboxylate transporter family receptor
RD15_RS13845	COG1802	Transcriptional regulator
RD15_RS13860	COG0583	DNA-binding transcription factor activity
RD15_RS13880	COG1695	Transcriptional regulator
RD15_RS13885	COG3568	Endonuclease Exonuclease Phosphatase
RD15_RS13890	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RD15_RS13905	COG0392	lysyltransferase activity
RD15_RS13945	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RD15_RS13955	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RD15_RS13965	COG1640	4-alpha-glucanotransferase
RD15_RS13980	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
RD15_RS14010	COG0667	Aldo Keto reductase
RD15_RS14025	COG2259	Doxx family
RD15_RS14055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD15_RS14075	COG0386	Belongs to the glutathione peroxidase family
RD15_RS14080	COG0625	glutathione transferase activity
RD15_RS14095	COG0095	Lipoate-protein ligase
RD15_RS14110	COG0688	phosphatidylethanolamine metabolic process
RD15_RS14120	COG1464	Belongs to the NlpA lipoprotein family
RD15_RS14135	COG2363	Small membrane protein
RD15_RS14160	COG3842	ATPase activity
RD15_RS14165	COG0395	ABC-type sugar transport system, permease component
RD15_RS14170	COG1175	transmembrane transport
RD15_RS14175	COG1653	transport
RD15_RS14185	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
RD15_RS14200	COG0559	Belongs to the binding-protein-dependent transport system permease family
RD15_RS14220	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RD15_RS14235	COG0697	spore germination
RD15_RS14245	COG2311	Membrane
RD15_RS14270	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RD15_RS14280	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RD15_RS14285	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RD15_RS14290	COG1760	l-serine dehydratase
RD15_RS14295	COG1283	sodium-dependent phosphate transmembrane transporter activity
RD15_RS14300	COG0412	Dienelactone hydrolase
RD15_RS14315	COG1611	Belongs to the LOG family
RD15_RS14335	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RD15_RS14340	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RD15_RS14345	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RD15_RS14350	COG2251	uridine kinase activity
RD15_RS14350	COG0195	Participates in both transcription termination and antitermination
RD15_RS14355	COG0779	Required for maturation of 30S ribosomal subunits
RD15_RS14360	COG1187	pseudouridine synthase activity
RD15_RS14365	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RD15_RS14375	COG0583	DNA-binding transcription factor activity
RD15_RS14385	COG0523	cobalamin synthesis protein
RD15_RS14405	COG0625	glutathione transferase activity
RD15_RS14410	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RD15_RS14415	COG1047	Peptidyl-prolyl cis-trans
RD15_RS14420	COG2003	Belongs to the UPF0758 family
RD15_RS14425	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
RD15_RS14430	COG3483	tryptophan 2,3-dioxygenase activity
RD15_RS14435	COG0254	rRNA binding
RD15_RS14445	COG0534	Mate efflux family protein
RD15_RS14465	COG2304	oxidoreductase activity
RD15_RS14485	COG1028	Short-chain dehydrogenase reductase Sdr
RD15_RS14490	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RD15_RS14495	COG1562	ergosterol biosynthetic process
RD15_RS14500	COG1562	ergosterol biosynthetic process
RD15_RS14505	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
RD15_RS14505	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
RD15_RS14510	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RD15_RS14520	COG0842	Transport permease protein
RD15_RS14525	COG1131	(ABC) transporter
RD15_RS14545	COG1477	protein flavinylation
RD15_RS14560	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
RD15_RS14575	COG5564	TIM-barrel signal transduction protein
RD15_RS14580	COG5441	Belongs to the UPF0261 family
RD15_RS14590	COG3468	outer membrane autotransporter barrel domain protein
RD15_RS14595	COG3468	outer membrane autotransporter barrel domain protein
RD15_RS14605	COG0542	response to heat
RD15_RS14610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RD15_RS14625	COG0494	nUDIX hydrolase
RD15_RS14630	COG3530	Putative quorum-sensing-regulated virulence factor
RD15_RS14640	COG1595	DNA-templated transcription, initiation
RD15_RS14645	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RD15_RS14680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD15_RS14685	COG0765	amino acid transport
RD15_RS14690	COG0765	amino acid transport
RD15_RS14715	COG2988	succinylglutamate desuccinylase activity
RD15_RS14740	COG3181	Tripartite tricarboxylate transporter family receptor
RD15_RS14745	COG2084	Dehydrogenase
RD15_RS14760	COG1619	proteins homologs of microcin C7 resistance protein MccF
RD15_RS14775	COG2814	Major facilitator Superfamily
RD15_RS14785	COG0583	DNA-binding transcription factor activity
RD15_RS14825	COG0672	)-iron permease
RD15_RS14840	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
RD15_RS14845	COG1028	Short-chain dehydrogenase reductase Sdr
RD15_RS14850	COG3243	poly(R)-hydroxyalkanoic acid synthase
RD15_RS14860	COG0564	pseudouridine synthase activity
RD15_RS14870	COG1199	ATP-dependent helicase activity
RD15_RS14875	COG2183	response to ionizing radiation
RD15_RS14880	COG0180	Tryptophanyl-tRNA synthetase
RD15_RS14905	COG4774	siderophore transport
RD15_RS14910	COG3712	iron ion homeostasis
RD15_RS14915	COG1595	DNA-templated transcription, initiation
RD15_RS14940	COG3181	Tripartite tricarboxylate transporter family receptor
RD15_RS14950	COG0583	DNA-binding transcription factor activity
RD15_RS14955	COG1028	Short-chain dehydrogenase reductase Sdr
RD15_RS14960	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RD15_RS14965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RD15_RS14970	COG0508	dehydrogenase complex catalyzes the overall conversion of
RD15_RS14975	COG0567	Dehydrogenase, E1 component
RD15_RS14980	COG1297	OPT oligopeptide transporter protein
RD15_RS14985	COG1297	OPT oligopeptide transporter protein
RD15_RS14990	COG1522	sequence-specific DNA binding
RD15_RS15000	COG0281	malic enzyme
RD15_RS15000	COG0280	phosphate acetyltransferase
RD15_RS15005	COG3539	Fimbrial protein
RD15_RS15020	COG0613	PHP domain protein
RD15_RS15055	COG0084	hydrolase, TatD family'
RD15_RS15060	COG1136	(ABC) transporter
RD15_RS15075	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RD15_RS15080	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RD15_RS15085	COG1028	Short-chain dehydrogenase reductase Sdr
RD15_RS15090	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RD15_RS15105	COG1022	Amp-dependent synthetase and ligase
RD15_RS15140	COG2205	protein histidine kinase activity
RD15_RS15145	COG0745	RESPONSE REGULATOR receiver
RD15_RS15150	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
RD15_RS15160	COG1295	ribonuclease BN
RD15_RS15175	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RD15_RS15200	COG1534	Rna-binding protein
RD15_RS15205	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
RD15_RS15210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RD15_RS15220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RD15_RS15230	COG0248	Ppx GppA phosphatase
RD15_RS15255	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RD15_RS15275	COG2732	(Barnase) inhibitor
RD15_RS15285	COG0280	phosphate acetyltransferase
RD15_RS15285	COG0281	malic enzyme
RD15_RS15295	COG0436	Aminotransferase
RD15_RS15300	COG0741	lytic transglycosylase activity
RD15_RS15305	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
RD15_RS15330	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RD15_RS15330	COG1648	precorrin-2 dehydrogenase activity
RD15_RS15335	COG3468	outer membrane autotransporter barrel domain protein
RD15_RS15345	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RD15_RS15350	COG2027	D-alanyl-D-alanine carboxypeptidase
RD15_RS15355	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RD15_RS15360	COG0343	queuine tRNA-ribosyltransferase activity
RD15_RS15370	COG1862	Preprotein translocase
RD15_RS15375	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RD15_RS15380	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RD15_RS15395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RD15_RS15400	COG1702	phosphate starvation-inducible protein PhoH
RD15_RS15405	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RD15_RS15410	COG4535	Mg2 and Co2 transporter CorC
RD15_RS15420	COG0667	Aldo Keto reductase
RD15_RS15445	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
RD15_RS15450	COG0745	RESPONSE REGULATOR receiver
RD15_RS15455	COG2201	protein-glutamate methylesterase activity
RD15_RS15465	COG0840	transmembrane signaling receptor activity
RD15_RS15480	COG0745	RESPONSE REGULATOR receiver
RD15_RS15515	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RD15_RS15525	COG0739	heme binding
RD15_RS15535	COG0521	Mo-molybdopterin cofactor biosynthetic process
RD15_RS15540	COG0306	phosphate transporter
RD15_RS15545	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
RD15_RS15575	COG0625	glutathione transferase activity
RD15_RS15590	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RD15_RS15595	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RD15_RS15600	COG0126	phosphoglycerate kinase activity
RD15_RS15605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RD15_RS15610	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RD15_RS15615	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RD15_RS15625	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RD15_RS15630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RD15_RS15640	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
RD15_RS15650	COG4566	intracellular signal transduction
RD15_RS15655	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RD15_RS15660	COG0339	signal peptide processing
RD15_RS15665	COG1999	signal sequence binding
RD15_RS15685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RD15_RS15695	COG1187	pseudouridine synthase activity
RD15_RS15700	COG3161	chorismate lyase activity
RD15_RS15705	COG2814	Major facilitator Superfamily
RD15_RS15715	COG0667	Aldo Keto reductase
RD15_RS15725	COG0335	large ribosomal subunit rRNA binding
RD15_RS15755	COG0175	sulfate reduction
RD15_RS15760	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RD15_RS15765	COG4208	sulfate ABC transporter
RD15_RS15770	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
RD15_RS15785	COG0450	alkyl hydroperoxide reductase
RD15_RS15790	COG1960	acyl-CoA dehydrogenase activity
RD15_RS15805	COG0123	including yeast histone deacetylase and acetoin utilization protein
RD15_RS15810	COG2951	lytic endotransglycosylase activity
RD15_RS15825	COG1555	photosystem II stabilization
RD15_RS15825	COG1596	polysaccharide export
RD15_RS15830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RD15_RS15835	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
RD15_RS15840	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
RD15_RS15860	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RD15_RS15865	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RD15_RS15870	COG0287	Prephenate dehydrogenase
RD15_RS15880	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RD15_RS15895	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RD15_RS15905	COG2814	Major facilitator Superfamily
RD15_RS15930	COG0583	DNA-binding transcription factor activity
RD15_RS15970	COG0583	DNA-binding transcription factor activity
RD15_RS15985	COG0179	Fumarylacetoacetate (FAA) hydrolase
RD15_RS16010	COG1053	succinate dehydrogenase
RD15_RS16015	COG1012	belongs to the aldehyde dehydrogenase family
RD15_RS16020	COG2079	MmgE PrpD family protein
RD15_RS16030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD15_RS16045	COG0583	DNA-binding transcription factor activity
RD15_RS16080	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RD15_RS16095	COG0667	Aldo Keto reductase
RD15_RS16105	COG5265	(ABC) transporter
RD15_RS16150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RD15_RS16155	COG0439	Biotin carboxylase
RD15_RS16160	COG2188	Transcriptional regulator
RD15_RS16185	COG0511	ligase activity, forming carbon-carbon bonds
RD15_RS16215	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
RD15_RS16230	COG0500	methyltransferase
RD15_RS16235	COG5265	(ABC) transporter
RD15_RS16250	COG0308	aminopeptidase N
RD15_RS16255	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
RD15_RS16265	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RD15_RS16270	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RD15_RS16275	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RD15_RS16280	COG0560	Phosphoserine phosphatase
RD15_RS16285	COG0583	DNA-binding transcription factor activity
RD15_RS16290	COG3181	Tripartite tricarboxylate transporter family receptor
RD15_RS16295	COG0028	Belongs to the TPP enzyme family
RD15_RS16310	COG4774	siderophore transport
RD15_RS16315	COG4774	siderophore transport
RD15_RS16325	COG1007	ATP synthesis coupled electron transport
RD15_RS16340	COG0713	ATP synthesis coupled electron transport
RD15_RS16350	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RD15_RS16355	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
RD15_RS16360	COG1034	ATP synthesis coupled electron transport
RD15_RS16370	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
RD15_RS16375	COG0649	NAD binding
RD15_RS16380	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RD15_RS16385	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RD15_RS16390	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RD15_RS16395	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RD15_RS16420	COG0671	phosphoesterase, PA-phosphatase related
RD15_RS16430	COG1597	lipid kinase activity
RD15_RS16435	COG0583	DNA-binding transcription factor activity
RD15_RS16440	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RD15_RS16450	COG1733	regulation of RNA biosynthetic process
RD15_RS16455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RD15_RS16460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RD15_RS16475	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
RD15_RS16495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD15_RS16515	COG3608	succinylglutamate desuccinylase aspartoacylase
RD15_RS16520	COG0626	cystathionine gamma-synthase activity
RD15_RS16525	COG0583	DNA-binding transcription factor activity
RD15_RS16565	COG3799	methylaspartate ammonia-lyase activity
RD15_RS16575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RD15_RS16585	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RD15_RS16590	COG0149	triose-phosphate isomerase activity
RD15_RS16610	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RD15_RS16625	COG1185	polyribonucleotide nucleotidyltransferase activity
RD15_RS16630	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RD15_RS16640	COG1183	phosphatidylcholine synthase activity
RD15_RS16645	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RD15_RS16650	COG0440	acetolactate synthase activity
RD15_RS16655	COG0028	Belongs to the TPP enzyme family
RD15_RS16675	COG0028	Belongs to the TPP enzyme family
RD15_RS16695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD15_RS16705	COG0318	PFAM AMP-dependent synthetase and ligase
RD15_RS16715	COG1802	Transcriptional regulator
RD15_RS16725	COG1802	Transcriptional regulator
RD15_RS16735	COG1028	Short-chain dehydrogenase reductase Sdr
RD15_RS16755	COG1126	abc transporter atp-binding protein
RD15_RS16760	COG0765	amino acid transport
RD15_RS16780	COG1538	Outer membrane efflux protein
RD15_RS16785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RD15_RS16790	COG2274	protein secretion by the type I secretion system
RD15_RS16795	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
RD15_RS16805	COG2994	toxin metabolic process
RD15_RS16820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD15_RS16825	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
RD15_RS16835	COG0583	DNA-binding transcription factor activity
RD15_RS16845	COG0142	geranyltranstransferase activity
RD15_RS16855	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RD15_RS16860	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RD15_RS16865	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RD15_RS16870	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RD15_RS16910	COG3712	iron ion homeostasis
RD15_RS16915	COG4774	siderophore transport
RD15_RS16920	COG2353	YceI-like domain
RD15_RS16940	COG0019	diaminopimelate decarboxylase activity
RD15_RS16960	COG0747	negative chemotaxis
RD15_RS16965	COG0601	transmembrane transport
RD15_RS16970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD15_RS16980	COG0154	amidase activity
RD15_RS16985	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RD15_RS17010	COG2154	pterin-4-alpha-carbinolamine dehydratase
RD15_RS17020	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RD15_RS17030	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RD15_RS17035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RD15_RS17040	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RD15_RS17045	COG1929	Belongs to the glycerate kinase type-1 family
RD15_RS17050	COG0469	pyruvate kinase activity
RD15_RS17055	COG0700	Nucleoside recognition
RD15_RS17085	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
RD15_RS17090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RD15_RS17105	COG0823	Involved in the tonB-independent uptake of proteins
RD15_RS17115	COG0848	biopolymer transport protein
RD15_RS17120	COG0811	peptide transport
RD15_RS17125	COG0824	Thioesterase
RD15_RS17130	COG0442	prolyl-tRNA aminoacylation
RD15_RS17135	COG0494	nUDIX hydrolase
RD15_RS17150	COG2135	peptidase activity
RD15_RS17215	COG1196	nuclear chromosome segregation
RD15_RS17360	COG0513	Belongs to the DEAD box helicase family
RD15_RS17390	COG0429	hydrolase of the alpha beta-hydrolase fold
RD15_RS17395	COG4783	chaperone-mediated protein folding
RD15_RS17410	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RD15_RS17435	COG0006	proline dipeptidase activity
RD15_RS17445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RD15_RS17465	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RD15_RS17470	COG0632	four-way junction helicase activity
RD15_RS17485	COG2255	four-way junction helicase activity
RD15_RS17490	COG0514	ATP-dependent DNA helicase (RecQ)
RD15_RS17505	COG0288	reversible hydration of carbon dioxide
RD15_RS17510	COG0154	amidase activity
RD15_RS17520	COG4211	Belongs to the binding-protein-dependent transport system permease family
RD15_RS17550	COG1464	Belongs to the NlpA lipoprotein family
RD15_RS17565	COG1058	Belongs to the CinA family
RD15_RS17565	COG1546	Belongs to the CinA family
RD15_RS17570	COG1414	Transcriptional regulator
RD15_RS17590	COG0167	dihydroorotate dehydrogenase activity
RD15_RS17595	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
RD15_RS17605	COG0583	DNA-binding transcription factor activity
RD15_RS17665	COG0280	phosphate acetyltransferase
RD15_RS17665	COG0281	malic enzyme
RD15_RS17675	COG0601	transmembrane transport
RD15_RS17680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD15_RS17685	COG4172	Belongs to the ABC transporter superfamily
RD15_RS17715	COG0640	Transcriptional regulator
RD15_RS17730	COG3135	benzoate transporter
RD15_RS17735	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RD15_RS17740	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RD15_RS17745	COG0742	ribosomal rna small subunit methyltransferase
RD15_RS17765	COG3639	organic phosphonate transmembrane transporter activity
RD15_RS17770	COG3639	organic phosphonate transmembrane transporter activity
RD15_RS17775	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RD15_RS17810	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RD15_RS17815	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RD15_RS17825	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RD15_RS17830	COG1058	Belongs to the CinA family
RD15_RS17830	COG1546	Belongs to the CinA family
RD15_RS17835	COG0284	orotidine-5'-phosphate decarboxylase activity
RD15_RS17840	COG1252	NADH dehydrogenase
RD15_RS17855	COG3468	outer membrane autotransporter barrel domain protein
RD15_RS17860	COG0459	protein refolding
RD15_RS17865	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RD15_RS17885	COG1053	succinate dehydrogenase
RD15_RS17895	COG0583	DNA-binding transcription factor activity
RD15_RS17900	COG1053	succinate dehydrogenase
RD15_RS17920	COG3706	GGDEF domain
RD15_RS17955	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RD15_RS17960	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
RD15_RS17970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RD15_RS17980	COG0069	glutamate synthase activity
RD15_RS17985	COG2391	methyltransferase activity
RD15_RS17990	COG0679	Auxin Efflux Carrier
RD15_RS18015	COG0557	exoribonuclease II activity
RD15_RS18020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RD15_RS18030	COG3128	pkhd-type hydroxylase
RD15_RS18035	COG0776	regulation of translation
RD15_RS18065	COG0642	Histidine kinase
RD15_RS18070	COG3158	transport of potassium into the cell
RD15_RS18075	COG0137	argininosuccinate synthase activity
RD15_RS18080	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RD15_RS18085	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RD15_RS18095	COG0583	DNA-binding transcription factor activity
RD15_RS18105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RD15_RS18125	COG2186	Transcriptional regulator
RD15_RS18135	COG2223	nitrite transmembrane transporter activity
RD15_RS18145	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RD15_RS18150	COG0450	alkyl hydroperoxide reductase
RD15_RS18170	COG1214	PFAM Peptidase M22, glycoprotease
RD15_RS18175	COG1573	uracil-dna glycosylase
RD15_RS18180	COG0477	Major facilitator Superfamily
RD15_RS18185	COG1196	nuclear chromosome segregation
RD15_RS18195	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RD15_RS18200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RD15_RS18215	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RD15_RS18220	COG1122	ATPase activity
RD15_RS18225	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
RD15_RS18230	COG1268	BioY protein
RD15_RS18250	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RD15_RS18285	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RD15_RS18290	COG2878	Part of a membrane complex involved in electron transport
RD15_RS18305	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RD15_RS18310	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
RD15_RS18315	COG0251	oxidation-reduction process
RD15_RS18325	COG3228	Belongs to the MtfA family
RD15_RS18330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RD15_RS18340	COG0133	tryptophan synthase activity
RD15_RS18345	COG0159	tryptophan synthase activity
RD15_RS18350	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RD15_RS18355	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
RD15_RS18375	COG4206	TonB-dependent receptor
RD15_RS18380	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RD15_RS18385	COG2022	thiamine diphosphate biosynthetic process
RD15_RS18390	COG0351	phosphomethylpyrimidine kinase
RD15_RS18395	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RD15_RS18410	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RD15_RS18420	COG0628	permease
RD15_RS18430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RD15_RS18440	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RD15_RS18445	COG0049	tRNA binding
RD15_RS18450	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RD15_RS18455	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RD15_RS18460	COG0051	transcription antitermination factor activity, RNA binding
RD15_RS18465	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RD15_RS18470	COG0088	Forms part of the polypeptide exit tunnel
RD15_RS18475	COG0089	rRNA binding
RD15_RS18480	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RD15_RS18485	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RD15_RS18490	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RD15_RS18495	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RD15_RS18500	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RD15_RS18505	COG0255	Belongs to the universal ribosomal protein uL29 family
RD15_RS18510	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RD15_RS18530	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RD15_RS18535	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RD15_RS18540	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RD15_RS18545	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RD15_RS18550	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RD15_RS18555	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RD15_RS18560	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RD15_RS18565	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RD15_RS18570	COG1841	ribosomal large subunit assembly
RD15_RS18575	COG0200	Binds to the 23S rRNA
RD15_RS18580	COG0201	protein transport
RD15_RS18585	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RD15_RS18590	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RD15_RS18595	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RD15_RS18600	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RD15_RS18605	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RD15_RS18610	COG0202	RNA polymerase activity
RD15_RS18615	COG0203	ribosomal protein L17
RD15_RS18625	COG1324	tolerance protein
RD15_RS18630	COG4232	protein-disulfide reductase activity
RD15_RS18645	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RD15_RS18655	COG1333	cytochrome c biogenesis protein
RD15_RS18660	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RD15_RS18670	COG1965	Belongs to the frataxin family
RD15_RS18680	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RD15_RS18685	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RD15_RS18690	COG0232	Belongs to the dGTPase family. Type 2 subfamily
RD15_RS18705	COG2814	Major facilitator Superfamily
RD15_RS18710	COG0629	single-stranded DNA binding
RD15_RS18750	COG0402	S-adenosylhomocysteine deaminase activity
RD15_RS18760	COG0438	transferase activity, transferring glycosyl groups
RD15_RS18780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD15_RS18805	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RD15_RS18810	COG2186	Transcriptional regulator
RD15_RS18830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RD15_RS18835	COG1956	GAF domain-containing protein
RD15_RS18840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RD15_RS18850	COG1652	LysM domain
RD15_RS18865	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RD15_RS18880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RD15_RS18905	COG3181	Tripartite tricarboxylate transporter family receptor
RD15_RS18920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD15_RS18935	COG1024	Enoyl-CoA hydratase
RD15_RS18950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD15_RS18955	COG1309	transcriptional regulator
RD15_RS18960	COG2816	NAD+ diphosphatase activity
RD15_RS18965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RD15_RS19050	COG2814	Major facilitator Superfamily
RD15_RS19055	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RD15_RS19075	COG1999	signal sequence binding
RD15_RS19080	COG0109	protoheme IX farnesyltransferase activity
RD15_RS19120	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RD15_RS19140	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RD15_RS19145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RD15_RS19155	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
RD15_RS19160	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
RD15_RS19170	COG0067	glutamate synthase
RD15_RS19170	COG0069	glutamate synthase activity
RD15_RS19170	COG0070	glutamate synthase
RD15_RS19180	COG3047	cAMP biosynthetic process
RD15_RS19190	COG1127	ABC transporter
RD15_RS19195	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RD15_RS19200	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RD15_RS19205	COG2853	Lipoprotein
RD15_RS19215	COG1131	(ABC) transporter
RD15_RS19220	COG0842	Transport permease protein
RD15_RS19230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RD15_RS19235	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RD15_RS19240	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RD15_RS19245	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RD15_RS19250	COG0131	Imidazoleglycerol-phosphate dehydratase
RD15_RS19255	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RD15_RS19260	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RD15_RS19265	COG0107	imidazoleglycerol-phosphate synthase activity
RD15_RS19270	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RD15_RS19275	COG0140	phosphoribosyl-ATP diphosphatase activity
RD15_RS19280	COG0537	adenosine 5'-monophosphoramidase activity
RD15_RS19285	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RD15_RS19290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RD15_RS19305	COG3181	Tripartite tricarboxylate transporter family receptor
RD15_RS19340	COG3702	type iv secretory pathway
RD15_RS19345	COG3451	type IV secretory pathway VirB4
RD15_RS19360	COG3736	Type IV secretory pathway, component VirB8
RD15_RS19365	COG3504	Conjugal transfer protein
RD15_RS19370	COG2948	multi-organism process
RD15_RS19375	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
RD15_RS19385	COG0697	spore germination
RD15_RS19405	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RD15_RS19410	COG0747	negative chemotaxis
RD15_RS19415	COG0601	transmembrane transport
RD15_RS19420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD15_RS19425	COG0444	Belongs to the ABC transporter superfamily
RD15_RS19435	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
RD15_RS19445	COG0494	nUDIX hydrolase
RD15_RS19480	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
RD15_RS19485	COG0237	dephospho-CoA kinase activity
RD15_RS19490	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
RD15_RS19505	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RD15_RS19510	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
RD15_RS19520	COG0477	Major facilitator Superfamily
RD15_RS19525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RD15_RS19540	COG1126	abc transporter atp-binding protein
RD15_RS19545	COG0765	amino acid transport
RD15_RS19550	COG4597	amino acid ABC transporter
RD15_RS19555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD15_RS19560	COG2884	Cell division ATP-binding protein ftsE
RD15_RS19565	COG2177	Part of the ABC transporter FtsEX involved in
RD15_RS19570	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
RD15_RS19580	COG1194	a g-specific adenine glycosylase
RD15_RS19590	COG2226	methyltransferase
RD15_RS19600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD15_RS19605	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD15_RS19620	COG1024	Enoyl-CoA hydratase
RD15_RS19640	COG1024	Enoyl-CoA hydratase
RD15_RS19645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD15_RS19650	COG3181	Tripartite tricarboxylate transporter family receptor
RD15_RS19660	COG0753	catalase activity
RD15_RS19665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD15_RS19670	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
RD15_RS19680	COG2175	clavaminate synthase activity
RD15_RS19685	COG1473	amidohydrolase
RD15_RS19690	COG4608	Belongs to the ABC transporter superfamily
RD15_RS19695	COG0444	Belongs to the ABC transporter superfamily
RD15_RS19710	COG0747	negative chemotaxis
RD15_RS19715	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RD15_RS19750	COG0436	Aminotransferase
RD15_RS19755	COG1278	Cold shock