locus-tag	class	description
CXD75_RS00005	COG0445	tRNA wobble uridine modification
CXD75_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
CXD75_RS00015	COG1192	Involved in chromosome partitioning
CXD75_RS00025	COG1475	DNA binding
CXD75_RS00050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CXD75_RS00060	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CXD75_RS00070	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CXD75_RS00075	COG0081	regulation of translation
CXD75_RS00080	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CXD75_RS00085	COG0222	ribosome binding
CXD75_RS00090	COG0085	RNA polymerase activity
CXD75_RS00095	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CXD75_RS00135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD75_RS00160	COG1024	Enoyl-CoA hydratase
CXD75_RS00180	COG0752	glycyl-tRNA synthetase alpha subunit
CXD75_RS00185	COG0751	glycine-tRNA ligase activity
CXD75_RS00190	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CXD75_RS00195	COG0204	Acyl-transferase
CXD75_RS00210	COG0242	peptide deformylase activity
CXD75_RS00250	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CXD75_RS00255	COG2813	Specifically methylates the guanine in position
CXD75_RS00255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CXD75_RS00270	COG2223	nitrite transmembrane transporter activity
CXD75_RS00280	COG1794	racemase activity, acting on amino acids and derivatives
CXD75_RS00285	COG1126	abc transporter atp-binding protein
CXD75_RS00290	COG0765	amino acid transport
CXD75_RS00295	COG0765	amino acid transport
CXD75_RS00300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD75_RS00365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CXD75_RS00395	COG0326	Molecular chaperone. Has ATPase activity
CXD75_RS00400	COG0625	glutathione transferase activity
CXD75_RS00415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CXD75_RS00420	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CXD75_RS00450	COG0438	transferase activity, transferring glycosyl groups
CXD75_RS00455	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CXD75_RS00460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CXD75_RS00490	COG0859	PFAM glycosyl transferase family 9
CXD75_RS00505	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CXD75_RS00515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CXD75_RS00520	COG1127	ABC transporter
CXD75_RS00540	COG1686	Belongs to the peptidase S11 family
CXD75_RS00550	COG2921	Belongs to the UPF0250 family
CXD75_RS00555	COG0321	lipoyl(octanoyl) transferase activity
CXD75_RS00560	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CXD75_RS00595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CXD75_RS00605	COG0018	arginyl-trna synthetase
CXD75_RS00625	COG0395	ABC-type sugar transport system, permease component
CXD75_RS00630	COG1175	transmembrane transport
CXD75_RS00635	COG1653	transport
CXD75_RS00640	COG3842	ATPase activity
CXD75_RS00645	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CXD75_RS00655	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CXD75_RS00675	COG1609	Transcriptional regulator
CXD75_RS00685	COG0154	amidase activity
CXD75_RS00690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CXD75_RS00700	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CXD75_RS00710	COG0583	DNA-binding transcription factor activity
CXD75_RS00730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CXD75_RS00745	COG1802	Transcriptional regulator
CXD75_RS00760	COG1024	Enoyl-CoA hydratase
CXD75_RS00770	COG3181	Tripartite tricarboxylate transporter family receptor
CXD75_RS00785	COG1984	allophanate hydrolase subunit 2
CXD75_RS00790	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CXD75_RS00800	COG0583	DNA-binding transcription factor activity
CXD75_RS00805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CXD75_RS00815	COG5002	protein histidine kinase activity
CXD75_RS00825	COG5002	protein histidine kinase activity
CXD75_RS00830	COG0745	RESPONSE REGULATOR receiver
CXD75_RS00835	COG2226	methyltransferase
CXD75_RS00850	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CXD75_RS00870	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CXD75_RS00880	COG0513	Belongs to the DEAD box helicase family
CXD75_RS00885	COG1280	lysine exporter protein (LysE YggA)
CXD75_RS00890	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CXD75_RS00930	COG1054	Belongs to the UPF0176 family
CXD75_RS00935	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CXD75_RS00935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CXD75_RS00945	COG0489	protein tyrosine kinase activity
CXD75_RS00960	COG0717	Belongs to the dCTP deaminase family
CXD75_RS00990	COG2081	HI0933 family
CXD75_RS01000	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CXD75_RS01010	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CXD75_RS01015	COG0509	glycine decarboxylation via glycine cleavage system
CXD75_RS01020	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CXD75_RS01020	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CXD75_RS01060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CXD75_RS01075	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CXD75_RS01085	COG1414	Transcriptional regulator
CXD75_RS01090	COG1028	Short-chain dehydrogenase reductase Sdr
CXD75_RS01095	COG2031	fatty acid transporter
CXD75_RS01100	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXD75_RS01110	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CXD75_RS01115	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CXD75_RS01125	COG4257	antibiotic catabolic process
CXD75_RS01150	COG1012	belongs to the aldehyde dehydrogenase family
CXD75_RS01155	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CXD75_RS01160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CXD75_RS01185	COG1028	Short-chain dehydrogenase reductase Sdr
CXD75_RS01195	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CXD75_RS01205	COG2188	Transcriptional regulator
CXD75_RS01210	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CXD75_RS01235	COG0617	tRNA 3'-terminal CCA addition
CXD75_RS01250	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CXD75_RS01255	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CXD75_RS01260	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CXD75_RS01265	COG0586	Pfam SNARE associated Golgi protein
CXD75_RS01270	COG0860	N-Acetylmuramoyl-L-alanine amidase
CXD75_RS01275	COG0802	atpase or kinase
CXD75_RS01280	COG0114	fumarate hydratase activity
CXD75_RS01290	COG3181	Tripartite tricarboxylate transporter family receptor
CXD75_RS01300	COG0405	Gamma-glutamyltransferase
CXD75_RS01305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD75_RS01340	COG1294	oxidase, subunit
CXD75_RS01350	COG4988	ABC transporter
CXD75_RS01355	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CXD75_RS01405	COG2969	positive regulation of protein catabolic process
CXD75_RS01410	COG0625	glutathione transferase activity
CXD75_RS01415	COG2857	Cytochrome c1
CXD75_RS01420	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CXD75_RS01425	COG0723	plastoquinol--plastocyanin reductase activity
CXD75_RS01430	COG1970	mechanosensitive ion channel activity
CXD75_RS01435	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CXD75_RS01450	COG2808	Putative FMN-binding domain
CXD75_RS01455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CXD75_RS01460	COG0747	negative chemotaxis
CXD75_RS01465	COG0657	acetylesterase activity
CXD75_RS01475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CXD75_RS01480	COG2207	Transcriptional regulator
CXD75_RS01485	COG0129	dihydroxy-acid dehydratase activity
CXD75_RS01490	COG2814	Major facilitator Superfamily
CXD75_RS01495	COG0583	DNA-binding transcription factor activity
CXD75_RS01505	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
CXD75_RS01575	COG1024	Enoyl-CoA hydratase
CXD75_RS01580	COG1960	acyl-CoA dehydrogenase activity
CXD75_RS01605	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CXD75_RS01610	COG0352	thiamine-phosphate diphosphorylase activity
CXD75_RS01625	COG1678	Uncharacterized ACR, COG1678
CXD75_RS01630	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CXD75_RS01635	COG0540	Belongs to the ATCase OTCase family
CXD75_RS01650	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CXD75_RS01660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CXD75_RS01695	COG1234	tRNA 3'-trailer cleavage
CXD75_RS01715	COG3064	Membrane
CXD75_RS01745	COG1683	Conserved Protein
CXD75_RS01750	COG1120	ATPase activity
CXD75_RS01755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXD75_RS01760	COG4558	Periplasmic binding protein
CXD75_RS01765	COG3720	iron ion transport
CXD75_RS01775	COG3712	iron ion homeostasis
CXD75_RS01780	COG1595	DNA-templated transcription, initiation
CXD75_RS01815	COG1802	Transcriptional regulator
CXD75_RS01825	COG3069	C4-dicarboxylate transmembrane transporter activity
CXD75_RS01835	COG1012	belongs to the aldehyde dehydrogenase family
CXD75_RS01870	COG2860	membrane
CXD75_RS01875	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CXD75_RS01880	COG0708	Exodeoxyribonuclease III
CXD75_RS01885	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CXD75_RS01890	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CXD75_RS01895	COG0154	amidase activity
CXD75_RS01900	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CXD75_RS01905	COG1077	Cell shape determining protein MreB Mrl
CXD75_RS01910	COG1792	Involved in formation and maintenance of cell shape
CXD75_RS01920	COG0768	penicillin binding
CXD75_RS01925	COG0772	Belongs to the SEDS family
CXD75_RS01930	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CXD75_RS01935	COG0471	metal ion transport
CXD75_RS01940	COG1309	transcriptional regulator
CXD75_RS01950	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CXD75_RS01965	COG2823	Periplasmic or secreted lipoprotein
CXD75_RS01970	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CXD75_RS01985	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CXD75_RS02005	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD75_RS02015	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD75_RS02035	COG0492	ferredoxin-NADP+ reductase activity
CXD75_RS02045	COG3181	Tripartite tricarboxylate transporter family receptor
CXD75_RS02050	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXD75_RS02050	COG1024	Enoyl-CoA hydratase
CXD75_RS02055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD75_RS02060	COG0028	Belongs to the TPP enzyme family
CXD75_RS02085	COG3181	Tripartite tricarboxylate transporter family receptor
CXD75_RS02100	COG0697	spore germination
CXD75_RS02130	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CXD75_RS02135	COG0463	Glycosyl transferase, family 2
CXD75_RS02150	COG0786	glutamate:sodium symporter activity
CXD75_RS02160	COG2031	fatty acid transporter
CXD75_RS02175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CXD75_RS02190	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CXD75_RS02205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXD75_RS02215	COG1285	pathogenesis
CXD75_RS02220	COG1253	flavin adenine dinucleotide binding
CXD75_RS02225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD75_RS02230	COG1024	Enoyl-CoA hydratase
CXD75_RS02235	COG3181	Tripartite tricarboxylate transporter family receptor
CXD75_RS02240	COG0583	DNA-binding transcription factor activity
CXD75_RS02245	COG1960	acyl-CoA dehydrogenase activity
CXD75_RS02255	COG0183	Belongs to the thiolase family
CXD75_RS02275	COG0583	DNA-binding transcription factor activity
CXD75_RS02280	COG1278	Cold shock
CXD75_RS02290	COG1802	Transcriptional regulator
CXD75_RS02295	COG1012	belongs to the aldehyde dehydrogenase family
CXD75_RS02300	COG2031	fatty acid transporter
CXD75_RS02305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CXD75_RS02305	COG1017	nitric oxide dioxygenase activity
CXD75_RS02310	COG0251	oxidation-reduction process
CXD75_RS02330	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD75_RS02340	COG0583	DNA-binding transcription factor activity
CXD75_RS02345	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD75_RS02360	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CXD75_RS02365	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CXD75_RS02370	COG0546	phosphoglycolate phosphatase activity
CXD75_RS02380	COG1530	ribonuclease E activity
CXD75_RS02400	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CXD75_RS02405	COG0159	tryptophan synthase activity
CXD75_RS02410	COG0133	tryptophan synthase activity
CXD75_RS02420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CXD75_RS02425	COG3228	Belongs to the MtfA family
CXD75_RS02435	COG0251	oxidation-reduction process
CXD75_RS02440	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CXD75_RS02445	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CXD75_RS02460	COG2878	Part of a membrane complex involved in electron transport
CXD75_RS02465	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CXD75_RS02500	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CXD75_RS02520	COG1268	BioY protein
CXD75_RS02525	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CXD75_RS02530	COG1122	ATPase activity
CXD75_RS02535	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CXD75_RS02550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CXD75_RS02555	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CXD75_RS02565	COG1196	nuclear chromosome segregation
CXD75_RS02570	COG0477	Major facilitator Superfamily
CXD75_RS02575	COG1573	uracil-dna glycosylase
CXD75_RS02580	COG1214	PFAM Peptidase M22, glycoprotease
CXD75_RS02600	COG0450	alkyl hydroperoxide reductase
CXD75_RS02605	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CXD75_RS02615	COG2223	nitrite transmembrane transporter activity
CXD75_RS02625	COG2186	Transcriptional regulator
CXD75_RS02645	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CXD75_RS02655	COG0583	DNA-binding transcription factor activity
CXD75_RS02665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CXD75_RS02670	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CXD75_RS02675	COG0137	argininosuccinate synthase activity
CXD75_RS02680	COG3158	transport of potassium into the cell
CXD75_RS02685	COG0642	Histidine kinase
CXD75_RS02715	COG0776	regulation of translation
CXD75_RS02720	COG3128	pkhd-type hydroxylase
CXD75_RS02730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CXD75_RS02735	COG0557	exoribonuclease II activity
CXD75_RS02760	COG0679	Auxin Efflux Carrier
CXD75_RS02765	COG2391	methyltransferase activity
CXD75_RS02770	COG0069	glutamate synthase activity
CXD75_RS02780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXD75_RS02790	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CXD75_RS02830	COG3706	GGDEF domain
CXD75_RS02855	COG1053	succinate dehydrogenase
CXD75_RS02860	COG0583	DNA-binding transcription factor activity
CXD75_RS02875	COG1053	succinate dehydrogenase
CXD75_RS02895	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CXD75_RS02900	COG0459	protein refolding
CXD75_RS02905	COG3468	outer membrane autotransporter barrel domain protein
CXD75_RS02920	COG1252	NADH dehydrogenase
CXD75_RS02925	COG0284	orotidine-5'-phosphate decarboxylase activity
CXD75_RS02930	COG1058	Belongs to the CinA family
CXD75_RS02930	COG1546	Belongs to the CinA family
CXD75_RS02935	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CXD75_RS02945	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CXD75_RS02950	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CXD75_RS02990	COG3639	organic phosphonate transmembrane transporter activity
CXD75_RS02995	COG3639	organic phosphonate transmembrane transporter activity
CXD75_RS03015	COG0742	ribosomal rna small subunit methyltransferase
CXD75_RS03020	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CXD75_RS03025	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CXD75_RS03030	COG3135	benzoate transporter
CXD75_RS03045	COG0640	Transcriptional regulator
CXD75_RS03075	COG4172	Belongs to the ABC transporter superfamily
CXD75_RS03080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD75_RS03085	COG0601	transmembrane transport
CXD75_RS03095	COG0281	malic enzyme
CXD75_RS03095	COG0280	phosphate acetyltransferase
CXD75_RS03155	COG0583	DNA-binding transcription factor activity
CXD75_RS03170	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CXD75_RS03175	COG0167	dihydroorotate dehydrogenase activity
CXD75_RS03195	COG1414	Transcriptional regulator
CXD75_RS03200	COG1546	Belongs to the CinA family
CXD75_RS03200	COG1058	Belongs to the CinA family
CXD75_RS03220	COG0513	Belongs to the DEAD box helicase family
CXD75_RS03250	COG0429	hydrolase of the alpha beta-hydrolase fold
CXD75_RS03255	COG4783	chaperone-mediated protein folding
CXD75_RS03270	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CXD75_RS03295	COG0006	proline dipeptidase activity
CXD75_RS03305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CXD75_RS03325	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CXD75_RS03330	COG0632	four-way junction helicase activity
CXD75_RS03345	COG2255	four-way junction helicase activity
CXD75_RS03350	COG0514	ATP-dependent DNA helicase (RecQ)
CXD75_RS03365	COG0288	reversible hydration of carbon dioxide
CXD75_RS03370	COG0154	amidase activity
CXD75_RS03380	COG4211	Belongs to the binding-protein-dependent transport system permease family
CXD75_RS03410	COG1464	Belongs to the NlpA lipoprotein family
CXD75_RS03550	COG1196	nuclear chromosome segregation
CXD75_RS03625	COG2135	peptidase activity
CXD75_RS03640	COG0494	nUDIX hydrolase
CXD75_RS03645	COG0442	prolyl-tRNA aminoacylation
CXD75_RS03650	COG0824	Thioesterase
CXD75_RS03655	COG0811	peptide transport
CXD75_RS03660	COG0848	biopolymer transport protein
CXD75_RS03670	COG0823	Involved in the tonB-independent uptake of proteins
CXD75_RS03685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXD75_RS03690	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CXD75_RS03725	COG0700	Nucleoside recognition
CXD75_RS03730	COG0469	pyruvate kinase activity
CXD75_RS03735	COG1929	Belongs to the glycerate kinase type-1 family
CXD75_RS03740	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CXD75_RS03745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CXD75_RS03750	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CXD75_RS03760	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CXD75_RS03770	COG2154	pterin-4-alpha-carbinolamine dehydratase
CXD75_RS03795	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CXD75_RS03800	COG0154	amidase activity
CXD75_RS03810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD75_RS03815	COG0601	transmembrane transport
CXD75_RS03820	COG0747	negative chemotaxis
CXD75_RS03840	COG0019	diaminopimelate decarboxylase activity
CXD75_RS03855	COG2353	YceI-like domain
CXD75_RS03860	COG4774	siderophore transport
CXD75_RS03865	COG3712	iron ion homeostasis
CXD75_RS03910	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CXD75_RS03915	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CXD75_RS03920	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CXD75_RS03925	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CXD75_RS03935	COG0142	geranyltranstransferase activity
CXD75_RS03945	COG0583	DNA-binding transcription factor activity
CXD75_RS03955	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
CXD75_RS03960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD75_RS03980	COG2994	toxin metabolic process
CXD75_RS03990	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CXD75_RS03995	COG2274	protein secretion by the type I secretion system
CXD75_RS04000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CXD75_RS04005	COG1538	Outer membrane efflux protein
CXD75_RS04025	COG0765	amino acid transport
CXD75_RS04030	COG1126	abc transporter atp-binding protein
CXD75_RS04050	COG1028	Short-chain dehydrogenase reductase Sdr
CXD75_RS04060	COG1802	Transcriptional regulator
CXD75_RS04070	COG1802	Transcriptional regulator
CXD75_RS04080	COG0318	PFAM AMP-dependent synthetase and ligase
CXD75_RS04090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD75_RS04110	COG0028	Belongs to the TPP enzyme family
CXD75_RS04130	COG0308	aminopeptidase N
CXD75_RS04135	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CXD75_RS04150	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CXD75_RS04155	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CXD75_RS04160	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CXD75_RS04165	COG0560	Phosphoserine phosphatase
CXD75_RS04170	COG0583	DNA-binding transcription factor activity
CXD75_RS04175	COG3181	Tripartite tricarboxylate transporter family receptor
CXD75_RS04180	COG0028	Belongs to the TPP enzyme family
CXD75_RS04195	COG4774	siderophore transport
CXD75_RS04200	COG4774	siderophore transport
CXD75_RS04210	COG1007	ATP synthesis coupled electron transport
CXD75_RS04225	COG0713	ATP synthesis coupled electron transport
CXD75_RS04235	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CXD75_RS04240	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CXD75_RS04245	COG1034	ATP synthesis coupled electron transport
CXD75_RS04255	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CXD75_RS04260	COG0649	NAD binding
CXD75_RS04265	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CXD75_RS04270	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CXD75_RS04275	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CXD75_RS04280	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CXD75_RS04310	COG0671	phosphoesterase, PA-phosphatase related
CXD75_RS04320	COG1597	lipid kinase activity
CXD75_RS04325	COG0583	DNA-binding transcription factor activity
CXD75_RS04330	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CXD75_RS04340	COG1733	regulation of RNA biosynthetic process
CXD75_RS04345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CXD75_RS04350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CXD75_RS04365	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
CXD75_RS04385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD75_RS04405	COG3608	succinylglutamate desuccinylase aspartoacylase
CXD75_RS04410	COG0626	cystathionine gamma-synthase activity
CXD75_RS04415	COG0583	DNA-binding transcription factor activity
CXD75_RS04450	COG3799	methylaspartate ammonia-lyase activity
CXD75_RS04460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CXD75_RS04470	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CXD75_RS04475	COG0149	triose-phosphate isomerase activity
CXD75_RS04495	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CXD75_RS04510	COG1185	polyribonucleotide nucleotidyltransferase activity
CXD75_RS04515	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CXD75_RS04530	COG1183	phosphatidylcholine synthase activity
CXD75_RS04535	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CXD75_RS04540	COG0440	acetolactate synthase activity
CXD75_RS04545	COG0028	Belongs to the TPP enzyme family
CXD75_RS04560	COG5265	(ABC) transporter
CXD75_RS04565	COG0500	methyltransferase
CXD75_RS04585	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CXD75_RS04605	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CXD75_RS04615	COG0511	ligase activity, forming carbon-carbon bonds
CXD75_RS04640	COG2188	Transcriptional regulator
CXD75_RS04645	COG0439	Biotin carboxylase
CXD75_RS04695	COG5265	(ABC) transporter
CXD75_RS04705	COG0667	Aldo Keto reductase
CXD75_RS04720	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CXD75_RS04760	COG0583	DNA-binding transcription factor activity
CXD75_RS04795	COG2814	Major facilitator Superfamily
CXD75_RS04805	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CXD75_RS04820	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CXD75_RS04830	COG0287	Prephenate dehydrogenase
CXD75_RS04835	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CXD75_RS04840	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CXD75_RS04860	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CXD75_RS04865	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CXD75_RS04870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CXD75_RS04875	COG1555	photosystem II stabilization
CXD75_RS04875	COG1596	polysaccharide export
CXD75_RS04890	COG2951	lytic endotransglycosylase activity
CXD75_RS04895	COG0123	including yeast histone deacetylase and acetoin utilization protein
CXD75_RS04910	COG1960	acyl-CoA dehydrogenase activity
CXD75_RS04915	COG0450	alkyl hydroperoxide reductase
CXD75_RS04935	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CXD75_RS04970	COG0335	large ribosomal subunit rRNA binding
CXD75_RS04985	COG0667	Aldo Keto reductase
CXD75_RS05000	COG3161	chorismate lyase activity
CXD75_RS05005	COG1187	pseudouridine synthase activity
CXD75_RS05035	COG1999	signal sequence binding
CXD75_RS05040	COG0339	signal peptide processing
CXD75_RS05045	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CXD75_RS05050	COG4566	intracellular signal transduction
CXD75_RS05060	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CXD75_RS05065	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXD75_RS05070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CXD75_RS05075	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CXD75_RS05085	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CXD75_RS05090	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CXD75_RS05095	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CXD75_RS05100	COG0126	phosphoglycerate kinase activity
CXD75_RS05105	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CXD75_RS05110	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CXD75_RS05125	COG0625	glutathione transferase activity
CXD75_RS05155	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CXD75_RS05165	COG0521	Mo-molybdopterin cofactor biosynthetic process
CXD75_RS05175	COG0739	heme binding
CXD75_RS05185	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CXD75_RS05225	COG0745	RESPONSE REGULATOR receiver
CXD75_RS05240	COG0840	transmembrane signaling receptor activity
CXD75_RS05250	COG2201	protein-glutamate methylesterase activity
CXD75_RS05255	COG0745	RESPONSE REGULATOR receiver
CXD75_RS05260	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CXD75_RS05285	COG0667	Aldo Keto reductase
CXD75_RS05295	COG4535	Mg2 and Co2 transporter CorC
CXD75_RS05300	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CXD75_RS05305	COG1702	phosphate starvation-inducible protein PhoH
CXD75_RS05310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CXD75_RS05325	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CXD75_RS05330	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CXD75_RS05335	COG1862	Preprotein translocase
CXD75_RS05340	COG0343	queuine tRNA-ribosyltransferase activity
CXD75_RS05345	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CXD75_RS05350	COG2027	D-alanyl-D-alanine carboxypeptidase
CXD75_RS05355	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CXD75_RS05365	COG3468	outer membrane autotransporter barrel domain protein
CXD75_RS05370	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CXD75_RS05370	COG1648	precorrin-2 dehydrogenase activity
CXD75_RS05395	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CXD75_RS05400	COG0741	lytic transglycosylase activity
CXD75_RS05410	COG0436	Aminotransferase
CXD75_RS05420	COG0281	malic enzyme
CXD75_RS05420	COG0280	phosphate acetyltransferase
CXD75_RS05430	COG2732	(Barnase) inhibitor
CXD75_RS05445	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CXD75_RS05470	COG0248	Ppx GppA phosphatase
CXD75_RS05480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CXD75_RS05490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CXD75_RS05495	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CXD75_RS05500	COG1534	Rna-binding protein
CXD75_RS05530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CXD75_RS05545	COG1295	ribonuclease BN
CXD75_RS05555	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CXD75_RS05560	COG0745	RESPONSE REGULATOR receiver
CXD75_RS05565	COG2205	protein histidine kinase activity
CXD75_RS05600	COG1022	Amp-dependent synthetase and ligase
CXD75_RS05615	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CXD75_RS05620	COG1028	Short-chain dehydrogenase reductase Sdr
CXD75_RS05630	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CXD75_RS05645	COG1136	(ABC) transporter
CXD75_RS05650	COG0084	hydrolase, TatD family'
CXD75_RS05675	COG0658	competence protein
CXD75_RS05675	COG2333	competence protein COMEC
CXD75_RS05685	COG0613	PHP domain protein
CXD75_RS05705	COG3539	Fimbrial protein
CXD75_RS05710	COG0281	malic enzyme
CXD75_RS05710	COG0280	phosphate acetyltransferase
CXD75_RS05720	COG1522	sequence-specific DNA binding
CXD75_RS05730	COG0567	Dehydrogenase, E1 component
CXD75_RS05735	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXD75_RS05740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CXD75_RS05745	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CXD75_RS05750	COG1028	Short-chain dehydrogenase reductase Sdr
CXD75_RS05755	COG0583	DNA-binding transcription factor activity
CXD75_RS05765	COG3181	Tripartite tricarboxylate transporter family receptor
CXD75_RS05790	COG0180	Tryptophanyl-tRNA synthetase
CXD75_RS05795	COG2183	response to ionizing radiation
CXD75_RS05800	COG1199	ATP-dependent helicase activity
CXD75_RS05810	COG0564	pseudouridine synthase activity
CXD75_RS05820	COG3243	poly(R)-hydroxyalkanoic acid synthase
CXD75_RS05825	COG1028	Short-chain dehydrogenase reductase Sdr
CXD75_RS05830	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
CXD75_RS05845	COG0672	)-iron permease
CXD75_RS05885	COG0583	DNA-binding transcription factor activity
CXD75_RS05895	COG2814	Major facilitator Superfamily
CXD75_RS05910	COG1619	proteins homologs of microcin C7 resistance protein MccF
CXD75_RS05925	COG2084	Dehydrogenase
CXD75_RS05930	COG3181	Tripartite tricarboxylate transporter family receptor
CXD75_RS05955	COG2988	succinylglutamate desuccinylase activity
CXD75_RS05980	COG0765	amino acid transport
CXD75_RS05985	COG0765	amino acid transport
CXD75_RS05990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD75_RS06025	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CXD75_RS06030	COG1595	DNA-templated transcription, initiation
CXD75_RS06040	COG3530	Putative quorum-sensing-regulated virulence factor
CXD75_RS06045	COG0494	nUDIX hydrolase
CXD75_RS06060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CXD75_RS06065	COG0542	response to heat
CXD75_RS06085	COG3468	outer membrane autotransporter barrel domain protein
CXD75_RS06095	COG5441	Belongs to the UPF0261 family
CXD75_RS06100	COG5564	TIM-barrel signal transduction protein
CXD75_RS06115	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CXD75_RS06130	COG1477	protein flavinylation
CXD75_RS06150	COG1131	(ABC) transporter
CXD75_RS06155	COG0842	Transport permease protein
CXD75_RS06165	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CXD75_RS06170	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CXD75_RS06170	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CXD75_RS06175	COG1562	ergosterol biosynthetic process
CXD75_RS06180	COG1562	ergosterol biosynthetic process
CXD75_RS06185	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CXD75_RS06190	COG1028	Short-chain dehydrogenase reductase Sdr
CXD75_RS06210	COG2304	oxidoreductase activity
CXD75_RS06230	COG0534	Mate efflux family protein
CXD75_RS06240	COG0254	rRNA binding
CXD75_RS06245	COG3483	tryptophan 2,3-dioxygenase activity
CXD75_RS06250	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CXD75_RS06255	COG2003	Belongs to the UPF0758 family
CXD75_RS06260	COG1047	Peptidyl-prolyl cis-trans
CXD75_RS06265	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CXD75_RS06270	COG0625	glutathione transferase activity
CXD75_RS06290	COG0523	cobalamin synthesis protein
CXD75_RS06300	COG0583	DNA-binding transcription factor activity
CXD75_RS06310	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CXD75_RS06315	COG1187	pseudouridine synthase activity
CXD75_RS06320	COG0779	Required for maturation of 30S ribosomal subunits
CXD75_RS06325	COG0195	Participates in both transcription termination and antitermination
CXD75_RS06325	COG2251	uridine kinase activity
CXD75_RS06330	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CXD75_RS06335	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CXD75_RS06340	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CXD75_RS06360	COG1611	Belongs to the LOG family
CXD75_RS06375	COG0412	Dienelactone hydrolase
CXD75_RS06380	COG1283	sodium-dependent phosphate transmembrane transporter activity
CXD75_RS06385	COG1760	l-serine dehydratase
CXD75_RS06390	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CXD75_RS06395	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CXD75_RS06405	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CXD75_RS06430	COG2311	Membrane
CXD75_RS06455	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CXD75_RS06475	COG0559	Belongs to the binding-protein-dependent transport system permease family
CXD75_RS06495	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CXD75_RS06505	COG1653	transport
CXD75_RS06510	COG1175	transmembrane transport
CXD75_RS06515	COG0395	ABC-type sugar transport system, permease component
CXD75_RS06520	COG3842	ATPase activity
CXD75_RS06545	COG2363	Small membrane protein
CXD75_RS06560	COG1464	Belongs to the NlpA lipoprotein family
CXD75_RS06570	COG0688	phosphatidylethanolamine metabolic process
CXD75_RS06585	COG0095	Lipoate-protein ligase
CXD75_RS06600	COG0625	glutathione transferase activity
CXD75_RS06605	COG0386	Belongs to the glutathione peroxidase family
CXD75_RS06625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD75_RS06655	COG2259	Doxx family
CXD75_RS06670	COG0667	Aldo Keto reductase
CXD75_RS06700	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CXD75_RS06720	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CXD75_RS06730	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CXD75_RS06780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXD75_RS06785	COG3568	Endonuclease Exonuclease Phosphatase
CXD75_RS06795	COG1695	Transcriptional regulator
CXD75_RS06815	COG0583	DNA-binding transcription factor activity
CXD75_RS06830	COG1802	Transcriptional regulator
CXD75_RS06840	COG3181	Tripartite tricarboxylate transporter family receptor
CXD75_RS06850	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD75_RS06865	COG0066	3-isopropylmalate dehydratase activity
CXD75_RS06875	COG3181	Tripartite tricarboxylate transporter family receptor
CXD75_RS06880	COG4948	Mandelate Racemase Muconate Lactonizing
CXD75_RS06895	COG1126	abc transporter atp-binding protein
CXD75_RS06900	COG0765	amino acid transport
CXD75_RS06905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD75_RS06945	COG1815	bacterial-type flagellum-dependent cell motility
CXD75_RS06950	COG1558	bacterial-type flagellum-dependent cell motility
CXD75_RS06960	COG1749	Flagellar hook protein flgE
CXD75_RS06975	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CXD75_RS06980	COG1706	bacterial-type flagellum-dependent cell motility
CXD75_RS06990	COG1256	bacterial-type flagellum assembly
CXD75_RS07000	COG0840	transmembrane signaling receptor activity
CXD75_RS07005	COG0840	transmembrane signaling receptor activity
CXD75_RS07010	COG0840	transmembrane signaling receptor activity
CXD75_RS07030	COG1338	Plays a role in the flagellum-specific transport system
CXD75_RS07050	COG1580	Controls the rotational direction of flagella during chemotaxis
CXD75_RS07075	COG1157	protein secretion by the type III secretion system
CXD75_RS07085	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CXD75_RS07095	COG1677	Flagellar hook-basal body complex protein FliE
CXD75_RS07105	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CXD75_RS07140	COG0285	dihydrofolate synthase activity
CXD75_RS07170	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CXD75_RS07175	COG0024	Methionine aminopeptidase
CXD75_RS07180	COG0052	Belongs to the universal ribosomal protein uS2 family
CXD75_RS07185	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CXD75_RS07190	COG0528	UMP kinase activity
CXD75_RS07195	COG0233	cytoplasmic translational termination
CXD75_RS07200	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CXD75_RS07210	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CXD75_RS07215	COG0750	zinc metalloprotease
CXD75_RS07220	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CXD75_RS07225	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CXD75_RS07230	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CXD75_RS07235	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CXD75_RS07245	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CXD75_RS07250	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CXD75_RS07255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CXD75_RS07260	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CXD75_RS07270	COG0519	Catalyzes the synthesis of GMP from XMP
CXD75_RS07270	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CXD75_RS07285	COG0330	HflC and HflK could
CXD75_RS07290	COG3706	GGDEF domain
CXD75_RS07295	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CXD75_RS07305	COG2867	negative regulation of translational initiation
CXD75_RS07315	COG1960	acyl-CoA dehydrogenase activity
CXD75_RS07320	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CXD75_RS07355	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CXD75_RS07360	COG0505	Belongs to the CarA family
CXD75_RS07365	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CXD75_RS07375	COG0406	alpha-ribazole phosphatase activity
CXD75_RS07385	COG3842	ATPase activity
CXD75_RS07405	COG5001	Diguanylate cyclase
CXD75_RS07410	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CXD75_RS07420	COG1763	Mo-molybdopterin cofactor biosynthetic process
CXD75_RS07425	COG0303	'Molybdopterin
CXD75_RS07430	COG0746	molybdenum cofactor guanylyltransferase activity
CXD75_RS07435	COG0489	protein tyrosine kinase activity
CXD75_RS07465	COG0243	molybdopterin cofactor binding
CXD75_RS07465	COG3383	formate dehydrogenase (NAD+) activity
CXD75_RS07500	COG1122	ATPase activity
CXD75_RS07510	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CXD75_RS07515	COG0066	3-isopropylmalate dehydratase activity
CXD75_RS07520	COG0473	3-isopropylmalate dehydrogenase activity
CXD75_RS07525	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CXD75_RS07535	COG0101	tRNA pseudouridine synthase activity
CXD75_RS07540	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CXD75_RS07555	COG0135	phosphoribosylanthranilate isomerase activity
CXD75_RS07570	COG3022	response to hydroperoxide
CXD75_RS07585	COG3023	N-Acetylmuramoyl-L-alanine amidase
CXD75_RS07595	COG0424	maF-like protein
CXD75_RS07600	COG1399	metal-binding, possibly nucleic acid-binding protein
CXD75_RS07605	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CXD75_RS07610	COG0416	fatty acid biosynthetic process
CXD75_RS07615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CXD75_RS07630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CXD75_RS07635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CXD75_RS07660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CXD75_RS07665	COG0481	GTPase activity
CXD75_RS07670	COG0681	Belongs to the peptidase S26 family
CXD75_RS07675	COG0571	ribonuclease III activity
CXD75_RS07680	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CXD75_RS07685	COG1381	Involved in DNA repair and RecF pathway recombination
CXD75_RS07695	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CXD75_RS07710	COG3181	Tripartite tricarboxylate transporter family receptor
CXD75_RS07715	COG0670	Belongs to the BI1 family
CXD75_RS07730	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CXD75_RS07740	COG0583	DNA-binding transcription factor activity
CXD75_RS07755	COG0583	DNA-binding transcription factor activity
CXD75_RS07770	COG0791	NLP P60 protein
CXD75_RS07780	COG3193	protein, possibly involved in utilization of glycolate and propanediol
CXD75_RS07790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CXD75_RS07795	COG0697	spore germination
CXD75_RS07800	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CXD75_RS07815	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CXD75_RS07845	COG1446	asparaginase
CXD75_RS07850	COG4172	Belongs to the ABC transporter superfamily
CXD75_RS07855	COG0747	negative chemotaxis
CXD75_RS07865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD75_RS07890	COG0504	CTP synthase activity
CXD75_RS07895	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CXD75_RS07905	COG0148	phosphopyruvate hydratase activity
CXD75_RS07910	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CXD75_RS07940	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CXD75_RS07950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CXD75_RS07975	COG1981	membrane
CXD75_RS08005	COG0039	L-malate dehydrogenase activity
CXD75_RS08010	COG2188	Transcriptional regulator
CXD75_RS08015	COG2009	succinate dehydrogenase
CXD75_RS08020	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CXD75_RS08025	COG1053	succinate dehydrogenase
CXD75_RS08030	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CXD75_RS08035	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CXD75_RS08040	COG0372	Belongs to the citrate synthase family
CXD75_RS08055	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CXD75_RS08055	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CXD75_RS08065	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CXD75_RS08070	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CXD75_RS08085	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CXD75_RS08090	COG3842	ATPase activity
CXD75_RS08095	COG1176	ABC-type spermidine putrescine transport system, permease component I
CXD75_RS08100	COG1177	transmembrane transport
CXD75_RS08125	COG1960	acyl-CoA dehydrogenase activity
CXD75_RS08130	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CXD75_RS08135	COG0704	Plays a role in the regulation of phosphate uptake
CXD75_RS08145	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CXD75_RS08150	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CXD75_RS08150	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CXD75_RS08155	COG1643	Atp-dependent helicase
CXD75_RS08170	COG0438	transferase activity, transferring glycosyl groups
CXD75_RS08175	COG0726	polysaccharide deacetylase
CXD75_RS08180	COG0463	Glycosyl transferase, family 2
CXD75_RS08185	COG0438	transferase activity, transferring glycosyl groups
CXD75_RS08190	COG2194	sulfuric ester hydrolase activity
CXD75_RS08215	COG0859	PFAM glycosyl transferase family 9
CXD75_RS08220	COG1132	(ABC) transporter
CXD75_RS08235	COG0077	Prephenate dehydratase
CXD75_RS08240	COG1530	ribonuclease E activity
CXD75_RS08290	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXD75_RS08295	COG0154	amidase activity
CXD75_RS08305	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CXD75_RS08320	COG0495	leucyl-tRNA aminoacylation
CXD75_RS08325	COG2814	Major facilitator Superfamily
CXD75_RS08355	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CXD75_RS08360	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CXD75_RS08365	COG2814	Major facilitator Superfamily
CXD75_RS08385	COG4176	ABC-type proline glycine betaine transport system permease component
CXD75_RS08395	COG1942	4-Oxalocrotonate Tautomerase
CXD75_RS08400	COG0183	Belongs to the thiolase family
CXD75_RS08410	COG1802	Transcriptional regulator
CXD75_RS08420	COG1024	Enoyl-CoA hydratase
CXD75_RS08435	COG2032	superoxide dismutase activity
CXD75_RS08450	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CXD75_RS08475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CXD75_RS08480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CXD75_RS08490	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CXD75_RS08495	COG0736	holo-[acyl-carrier-protein] synthase activity
CXD75_RS08500	COG1472	Belongs to the glycosyl hydrolase 3 family
CXD75_RS08505	COG0322	excinuclease ABC activity
CXD75_RS08510	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CXD75_RS08520	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CXD75_RS08520	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CXD75_RS08525	COG2224	Isocitrate lyase
CXD75_RS08545	COG0559	Belongs to the binding-protein-dependent transport system permease family
CXD75_RS08555	COG4638	Rieske (2fe-2S)
CXD75_RS08565	COG1024	Enoyl-CoA hydratase
CXD75_RS08575	COG0633	Ferredoxin
CXD75_RS08580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD75_RS08595	COG0183	Belongs to the thiolase family
CXD75_RS08610	COG0583	DNA-binding transcription factor activity
CXD75_RS08640	COG2346	COG2346, Truncated hemoglobins
CXD75_RS08770	COG2207	Transcriptional regulator
CXD75_RS08820	COG1132	(ABC) transporter
CXD75_RS08845	COG0659	secondary active sulfate transmembrane transporter activity
CXD75_RS08875	COG2169	Transcriptional regulator
CXD75_RS08880	COG5507	3-demethylubiquinone-9 3-methyltransferase
CXD75_RS08885	COG0384	phenazine biosynthesis protein PhzF
CXD75_RS08890	COG0583	DNA-binding transcription factor activity
CXD75_RS08895	COG2733	membrane
CXD75_RS08910	COG1012	belongs to the aldehyde dehydrogenase family
CXD75_RS08915	COG3284	Transcriptional regulator
CXD75_RS08935	COG1380	Effector of murein hydrolase LrgA
CXD75_RS08940	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CXD75_RS08940	COG4106	trans-aconitate 2-methyltransferase activity
CXD75_RS08950	COG0156	8-amino-7-oxononanoate synthase activity
CXD75_RS09020	COG1131	(ABC) transporter
CXD75_RS09025	COG0842	Transport permease protein
CXD75_RS09030	COG0628	permease
CXD75_RS09065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CXD75_RS09080	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CXD75_RS09085	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CXD75_RS09090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CXD75_RS09095	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CXD75_RS09100	COG0330	HflC and HflK could
CXD75_RS09105	COG0330	HflC and HflK could
CXD75_RS09110	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CXD75_RS09115	COG1923	regulation of RNA biosynthetic process
CXD75_RS09120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CXD75_RS09125	COG1160	GTP binding
CXD75_RS09130	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CXD75_RS09135	COG2976	Protein conserved in bacteria
CXD75_RS09140	COG0124	histidyl-tRNA synthetase
CXD75_RS09145	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CXD75_RS09155	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CXD75_RS09160	COG0105	UTP biosynthetic process
CXD75_RS09165	COG0525	valine-tRNA ligase activity
CXD75_RS09180	COG0642	Histidine kinase
CXD75_RS09205	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CXD75_RS09210	COG0336	Belongs to the RNA methyltransferase TrmD family
CXD75_RS09215	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CXD75_RS09220	COG0228	four-way junction DNA binding
CXD75_RS09230	COG0425	Belongs to the sulfur carrier protein TusA family
CXD75_RS09235	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CXD75_RS09280	COG0154	amidase activity
CXD75_RS09285	COG4172	Belongs to the ABC transporter superfamily
CXD75_RS09290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD75_RS09295	COG0601	transmembrane transport
CXD75_RS09300	COG0747	negative chemotaxis
CXD75_RS09330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD75_RS09340	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CXD75_RS09360	COG3395	kinase activity
CXD75_RS09375	COG1024	Enoyl-CoA hydratase
CXD75_RS09395	COG0633	Ferredoxin
CXD75_RS09400	COG0443	Heat shock 70 kDa protein
CXD75_RS09405	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CXD75_RS09410	COG0316	Belongs to the HesB IscA family
CXD75_RS09415	COG0822	iron-sulfur transferase activity
CXD75_RS09420	COG1104	cysteine desulfurase activity
CXD75_RS09430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CXD75_RS09435	COG0556	nucleotide-excision repair
CXD75_RS09445	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CXD75_RS09475	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CXD75_RS09495	COG1028	Short-chain dehydrogenase reductase Sdr
CXD75_RS09500	COG0183	Belongs to the thiolase family
CXD75_RS09510	COG1024	Enoyl-CoA hydratase
CXD75_RS09525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD75_RS09530	COG0583	DNA-binding transcription factor activity
CXD75_RS09535	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CXD75_RS09540	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CXD75_RS09545	COG0740	serine-type endopeptidase activity
CXD75_RS09550	COG0544	peptidyl-prolyl cis-trans isomerase activity
CXD75_RS09560	COG1278	Cold shock
CXD75_RS09570	COG1278	Cold shock
CXD75_RS09605	COG2171	N-acyltransferase activity
CXD75_RS09610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CXD75_RS09615	COG2890	protein-(glutamine-N5) methyltransferase activity
CXD75_RS09620	COG0488	(ABC) transporter
CXD75_RS09625	COG4771	TonB-dependent receptor
CXD75_RS09630	COG0210	DNA helicase
CXD75_RS09650	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CXD75_RS09655	COG0196	riboflavin kinase activity
CXD75_RS09660	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CXD75_RS09665	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CXD75_RS09670	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CXD75_RS09680	COG1522	sequence-specific DNA binding
CXD75_RS09700	COG2951	lytic endotransglycosylase activity
CXD75_RS09705	COG2833	Protein of unknown function (DUF455)
CXD75_RS09725	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CXD75_RS09725	COG0189	ligase activity
CXD75_RS09730	COG1181	Belongs to the D-alanine--D-alanine ligase family
CXD75_RS09730	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CXD75_RS09735	COG3237	CsbD-like
CXD75_RS09745	COG2823	Periplasmic or secreted lipoprotein
CXD75_RS09760	COG4181	ATPase activity
CXD75_RS09770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CXD75_RS09775	COG0584	glycerophosphoryl diester phosphodiesterase
CXD75_RS09780	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CXD75_RS09790	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CXD75_RS09790	COG0678	peroxiredoxin activity
CXD75_RS09800	COG0789	Transcriptional regulator
CXD75_RS09805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CXD75_RS09835	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CXD75_RS09840	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CXD75_RS09850	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CXD75_RS09855	COG2252	PERMEase
CXD75_RS09865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CXD75_RS09895	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CXD75_RS09900	COG2358	TRAP transporter, solute receptor (TAXI family
CXD75_RS09935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXD75_RS09940	COG1366	Belongs to the anti-sigma-factor antagonist family
CXD75_RS09945	COG2172	sigma factor antagonist activity
CXD75_RS09950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CXD75_RS09960	COG2208	phosphoserine phosphatase activity
CXD75_RS09960	COG2770	Histidine kinase
CXD75_RS09985	COG1595	DNA-templated transcription, initiation
CXD75_RS10000	COG4792	protein secretion
CXD75_RS10005	COG4791	protein targeting
CXD75_RS10010	COG4794	Type iii secretion
CXD75_RS10015	COG4790	Type iii secretion
CXD75_RS10050	COG4669	(LipO)protein
CXD75_RS10115	COG4789	Type iii secretion
CXD75_RS10145	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CXD75_RS10150	COG0840	transmembrane signaling receptor activity
CXD75_RS10155	COG2233	PERMEase
CXD75_RS10180	COG1840	ABC-type Fe3 transport system, periplasmic component
CXD75_RS10185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CXD75_RS10190	COG1178	ABC-type Fe3 transport system permease component
CXD75_RS10195	COG3842	ATPase activity
CXD75_RS10200	COG0583	DNA-binding transcription factor activity
CXD75_RS10220	COG0501	Belongs to the peptidase M48B family
CXD75_RS10230	COG0697	spore germination
CXD75_RS10240	COG1846	Transcriptional regulator
CXD75_RS10250	COG1566	PFAM secretion protein HlyD family protein
CXD75_RS10255	COG2814	Major facilitator Superfamily
CXD75_RS10260	COG0473	3-isopropylmalate dehydrogenase activity
CXD75_RS10270	COG0747	negative chemotaxis
CXD75_RS10280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD75_RS10295	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CXD75_RS10320	COG1012	belongs to the aldehyde dehydrogenase family
CXD75_RS10330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CXD75_RS10335	COG1115	amino acid carrier protein
CXD75_RS10340	COG0433	COG0433 Predicted ATPase
CXD75_RS10345	COG0217	transcriptional regulatory protein
CXD75_RS10350	COG0151	Belongs to the GarS family
CXD75_RS10355	COG0408	coproporphyrinogen oxidase activity
CXD75_RS10360	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CXD75_RS10365	COG0799	negative regulation of ribosome biogenesis
CXD75_RS10370	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CXD75_RS10375	COG0424	maF-like protein
CXD75_RS10380	COG3468	outer membrane autotransporter barrel domain protein
CXD75_RS10425	COG0427	acetyl-CoA hydrolase
CXD75_RS10430	COG0583	DNA-binding transcription factor activity
CXD75_RS10450	COG0730	response to heat
CXD75_RS10455	COG0697	spore germination
CXD75_RS10490	COG2885	chlorophyll binding
CXD75_RS10520	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CXD75_RS10525	COG3384	dioxygenase
CXD75_RS10540	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CXD75_RS10545	COG3474	cytochrome
CXD75_RS10555	COG1595	DNA-templated transcription, initiation
CXD75_RS10570	COG2204	response regulator
CXD75_RS10610	COG4964	Belongs to the GSP D family
CXD75_RS10665	COG1846	Transcriptional regulator
CXD75_RS10670	COG4172	Belongs to the ABC transporter superfamily
CXD75_RS10675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD75_RS10680	COG0601	transmembrane transport
CXD75_RS10685	COG0747	negative chemotaxis
CXD75_RS10695	COG0598	Magnesium transport protein CorA
CXD75_RS10700	COG0210	DNA helicase
CXD75_RS10715	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CXD75_RS10720	COG1012	belongs to the aldehyde dehydrogenase family
CXD75_RS10725	COG0483	inositol monophosphate 1-phosphatase activity
CXD75_RS10730	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CXD75_RS10740	COG1045	serine acetyltransferase
CXD75_RS10745	COG0166	Belongs to the GPI family
CXD75_RS10760	COG2197	response regulator
CXD75_RS10765	COG1846	Transcriptional regulator
CXD75_RS10785	COG1649	PFAM Uncharacterised BCR, COG1649
CXD75_RS10785	COG0726	polysaccharide deacetylase
CXD75_RS10790	COG1215	transferase activity, transferring glycosyl groups
CXD75_RS10800	COG1902	pentaerythritol trinitrate reductase activity
CXD75_RS10825	COG0251	oxidation-reduction process
CXD75_RS10835	COG1832	CoA-binding protein
CXD75_RS10840	COG1414	Transcriptional regulator
CXD75_RS10845	COG1902	pentaerythritol trinitrate reductase activity
CXD75_RS10845	COG0446	pyridine nucleotide-disulphide oxidoreductase
CXD75_RS10855	COG3842	ATPase activity
CXD75_RS10880	COG0583	DNA-binding transcription factor activity
CXD75_RS10890	COG1028	Short-chain dehydrogenase reductase Sdr
CXD75_RS10895	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CXD75_RS10900	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CXD75_RS10915	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CXD75_RS10915	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CXD75_RS10920	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXD75_RS10945	COG0527	aspartate kinase activity
CXD75_RS10950	COG0037	tRNA processing
CXD75_RS10960	COG0825	malonyl-CoA metabolic process
CXD75_RS10970	COG0215	cysteine-tRNA ligase activity
CXD75_RS10985	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CXD75_RS10990	COG1968	undecaprenyl-diphosphatase activity
CXD75_RS10995	COG1253	flavin adenine dinucleotide binding
CXD75_RS11000	COG0483	inositol monophosphate 1-phosphatase activity
CXD75_RS11020	COG0668	transmembrane transport
CXD75_RS11070	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CXD75_RS11085	COG2831	hemolysin activation secretion protein
CXD75_RS11090	COG3539	Fimbrial protein
CXD75_RS11095	COG3188	usher protein
CXD75_RS11100	COG3121	Chaperone
CXD75_RS11110	COG3210	domain, Protein
CXD75_RS11110	COG3064	Membrane
CXD75_RS11110	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CXD75_RS11115	COG2197	response regulator
CXD75_RS11120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD75_RS11120	COG2205	protein histidine kinase activity
CXD75_RS11130	COG4336	lyase activity
CXD75_RS11180	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CXD75_RS11190	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CXD75_RS11190	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CXD75_RS11200	COG0028	Belongs to the TPP enzyme family
CXD75_RS11215	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CXD75_RS11225	COG1126	abc transporter atp-binding protein
CXD75_RS11235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD75_RS11250	COG0084	hydrolase, TatD family'
CXD75_RS11255	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CXD75_RS11260	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CXD75_RS11265	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CXD75_RS11285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD75_RS11290	COG1959	2 iron, 2 sulfur cluster binding
CXD75_RS11295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CXD75_RS11295	COG1017	nitric oxide dioxygenase activity
CXD75_RS11330	COG0488	(ABC) transporter
CXD75_RS11335	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CXD75_RS11350	COG1024	Enoyl-CoA hydratase
CXD75_RS11355	COG1619	proteins homologs of microcin C7 resistance protein MccF
CXD75_RS11360	COG0590	tRNA wobble adenosine to inosine editing
CXD75_RS11385	COG2212	antiporter activity
CXD75_RS11390	COG1863	multisubunit Na H antiporter MnhE subunit
CXD75_RS11395	COG0651	ATP synthesis coupled electron transport
CXD75_RS11400	COG1006	Multisubunit Na H antiporter MnhC subunit
CXD75_RS11405	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CXD75_RS11405	COG2111	Na H antiporter
CXD75_RS11425	COG0583	DNA-binding transcription factor activity
CXD75_RS11430	COG1028	Short-chain dehydrogenase reductase Sdr
CXD75_RS11460	COG0431	NADPH-dependent FMN reductase
CXD75_RS11505	COG1028	Short-chain dehydrogenase reductase Sdr
CXD75_RS11510	COG0179	Fumarylacetoacetate (FAA) hydrolase
CXD75_RS11540	COG0625	glutathione transferase activity
CXD75_RS11550	COG2944	sequence-specific DNA binding
CXD75_RS11560	COG2197	response regulator
CXD75_RS11585	COG3119	arylsulfatase activity
CXD75_RS11620	COG0714	Associated with various cellular activities
CXD75_RS11640	COG1028	Short-chain dehydrogenase reductase Sdr
CXD75_RS11645	COG0861	Integral membrane protein TerC family
CXD75_RS11690	COG0300	oxidoreductase activity
CXD75_RS11715	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CXD75_RS11730	COG0438	transferase activity, transferring glycosyl groups
CXD75_RS11750	COG0463	Glycosyl transferase, family 2
CXD75_RS11770	COG0783	Belongs to the Dps family
CXD75_RS11785	COG0583	DNA-binding transcription factor activity
CXD75_RS11790	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CXD75_RS11805	COG0656	L-ascorbic acid biosynthetic process
CXD75_RS11815	COG0583	DNA-binding transcription factor activity
CXD75_RS11825	COG1840	ABC-type Fe3 transport system, periplasmic component
CXD75_RS11830	COG1178	ABC-type Fe3 transport system permease component
CXD75_RS11835	COG3842	ATPase activity
CXD75_RS11845	COG1741	Belongs to the pirin family
CXD75_RS11850	COG1741	Belongs to the pirin family
CXD75_RS11855	COG0583	DNA-binding transcription factor activity
CXD75_RS11860	COG2204	response regulator
CXD75_RS11870	COG0174	glutamine synthetase
CXD75_RS11875	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CXD75_RS11885	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CXD75_RS11890	COG2200	EAL domain
CXD75_RS11890	COG2199	diguanylate cyclase activity
CXD75_RS11910	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CXD75_RS11915	COG1561	YicC-like family, N-terminal region
CXD75_RS11935	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CXD75_RS11940	COG0791	NLP P60 protein
CXD75_RS11945	COG1028	Short-chain dehydrogenase reductase Sdr
CXD75_RS11950	COG2863	cytochrome
CXD75_RS11955	COG3258	Cytochrome c
CXD75_RS11960	COG0194	GDP metabolic process
CXD75_RS11965	COG1758	RNA polymerase activity
CXD75_RS11970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CXD75_RS11975	COG1126	abc transporter atp-binding protein
CXD75_RS11980	COG0765	amino acid transport
CXD75_RS11985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD75_RS12000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXD75_RS12005	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CXD75_RS12010	COG3539	Fimbrial protein
CXD75_RS12015	COG2850	peptidyl-arginine hydroxylation
CXD75_RS12020	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CXD75_RS12025	COG3360	Dodecin
CXD75_RS12070	COG0009	L-threonylcarbamoyladenylate synthase
CXD75_RS12075	COG2321	neutral zinc metallopeptidase
CXD75_RS12095	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CXD75_RS12100	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CXD75_RS12105	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CXD75_RS12115	COG1074	ATP-dependent DNA helicase activity
CXD75_RS12125	COG2814	Major facilitator Superfamily
CXD75_RS12135	COG1686	Belongs to the peptidase S11 family
CXD75_RS12150	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CXD75_RS12155	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CXD75_RS12160	COG4974	Belongs to the 'phage' integrase family
CXD75_RS12165	COG0583	DNA-binding transcription factor activity
CXD75_RS12170	COG0028	Belongs to the TPP enzyme family
CXD75_RS12185	COG0028	Belongs to the TPP enzyme family
CXD75_RS12190	COG1126	abc transporter atp-binding protein
CXD75_RS12195	COG0765	amino acid transport
CXD75_RS12210	COG1414	Transcriptional regulator
CXD75_RS12215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD75_RS12220	COG0009	L-threonylcarbamoyladenylate synthase
CXD75_RS12225	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CXD75_RS12230	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CXD75_RS12235	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CXD75_RS12245	COG2944	sequence-specific DNA binding
CXD75_RS12255	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CXD75_RS12310	COG1126	abc transporter atp-binding protein
CXD75_RS12315	COG0765	amino acid transport
CXD75_RS12320	COG0765	amino acid transport
CXD75_RS12325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD75_RS12335	COG2423	ornithine cyclodeaminase activity
CXD75_RS12350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CXD75_RS12355	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CXD75_RS12365	COG0189	ligase activity
CXD75_RS12370	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CXD75_RS12375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CXD75_RS12380	COG2197	response regulator
CXD75_RS12420	COG3022	response to hydroperoxide
CXD75_RS12430	COG1028	Short-chain dehydrogenase reductase Sdr
CXD75_RS12445	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CXD75_RS12475	COG2814	Major facilitator Superfamily
CXD75_RS12495	COG3706	GGDEF domain
CXD75_RS12520	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CXD75_RS12525	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CXD75_RS12530	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CXD75_RS12535	COG1674	ftsk spoiiie
CXD75_RS12540	COG0492	ferredoxin-NADP+ reductase activity
CXD75_RS12545	COG1193	negative regulation of DNA recombination
CXD75_RS12565	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CXD75_RS12580	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CXD75_RS12585	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CXD75_RS12590	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CXD75_RS12600	COG0745	RESPONSE REGULATOR receiver
CXD75_RS12645	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CXD75_RS12665	COG0612	Peptidase, M16
CXD75_RS12675	COG0443	Heat shock 70 kDa protein
CXD75_RS12685	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CXD75_RS12695	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CXD75_RS12700	COG1420	regulation of RNA biosynthetic process
CXD75_RS12705	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CXD75_RS12710	COG0497	DNA recombination
CXD75_RS12715	COG0735	belongs to the Fur family
CXD75_RS12720	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CXD75_RS12725	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CXD75_RS12730	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CXD75_RS12765	COG0446	pyridine nucleotide-disulphide oxidoreductase
CXD75_RS12765	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CXD75_RS12770	COG4311	Sarcosine oxidase, delta subunit
CXD75_RS12775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD75_RS12785	COG0583	DNA-binding transcription factor activity
CXD75_RS12795	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CXD75_RS12820	COG4964	Belongs to the GSP D family
CXD75_RS12880	COG0181	hydroxymethylbilane synthase activity
CXD75_RS12885	COG0861	Integral membrane protein TerC family
CXD75_RS12890	COG0861	Integral membrane protein TerC family
CXD75_RS12895	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CXD75_RS12900	COG0045	succinate-CoA ligase (ADP-forming) activity
CXD75_RS12910	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CXD75_RS12920	COG2137	regulation of response to DNA damage stimulus
CXD75_RS12925	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CXD75_RS12945	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXD75_RS12945	COG1024	Enoyl-CoA hydratase
CXD75_RS12950	COG3842	ATPase activity
CXD75_RS12965	COG1028	Short-chain dehydrogenase reductase Sdr
CXD75_RS12985	COG0583	DNA-binding transcription factor activity
CXD75_RS12990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD75_RS13000	COG2974	May be involved in recombination
CXD75_RS13005	COG0540	Belongs to the ATCase OTCase family
CXD75_RS13070	COG0776	regulation of translation
CXD75_RS13075	COG0072	phenylalanine-tRNA ligase activity
CXD75_RS13075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CXD75_RS13080	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CXD75_RS13085	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CXD75_RS13090	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CXD75_RS13100	COG0756	dUTP diphosphatase activity
CXD75_RS13110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXD75_RS13125	COG0500	methyltransferase
CXD75_RS13140	COG0586	Pfam SNARE associated Golgi protein
CXD75_RS13170	COG1609	Transcriptional regulator
CXD75_RS13175	COG4172	Belongs to the ABC transporter superfamily
CXD75_RS13180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD75_RS13185	COG0601	transmembrane transport
CXD75_RS13190	COG0747	negative chemotaxis
CXD75_RS13205	COG1280	lysine exporter protein (LysE YggA)
CXD75_RS13220	COG2814	Major facilitator Superfamily
CXD75_RS13250	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CXD75_RS13270	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CXD75_RS13305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD75_RS13310	COG1116	anion transmembrane transporter activity
CXD75_RS13320	COG1228	amidohydrolase
CXD75_RS13335	COG0477	Major facilitator Superfamily
CXD75_RS13345	COG3550	peptidyl-serine autophosphorylation
CXD75_RS13360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CXD75_RS13360	COG0519	Catalyzes the synthesis of GMP from XMP
CXD75_RS13405	COG0420	3'-5' exonuclease activity
CXD75_RS13410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD75_RS13440	COG0395	ABC-type sugar transport system, permease component
CXD75_RS13450	COG3842	ATPase activity
CXD75_RS13475	COG3181	Tripartite tricarboxylate transporter family receptor
CXD75_RS13510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXD75_RS13535	COG0602	queuosine metabolic process
CXD75_RS13540	COG0720	synthase
CXD75_RS13545	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CXD75_RS13550	COG0235	Class ii aldolase
CXD75_RS13580	COG3064	Membrane
CXD75_RS13580	COG3210	domain, Protein
CXD75_RS13580	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CXD75_RS13585	COG0047	phosphoribosylformylglycinamidine synthase activity
CXD75_RS13585	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CXD75_RS13590	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CXD75_RS13595	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CXD75_RS13595	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CXD75_RS13600	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CXD75_RS13620	COG3539	Fimbrial protein
CXD75_RS13630	COG2050	protein possibly involved in aromatic compounds catabolism
CXD75_RS13635	COG1024	Enoyl-CoA hydratase
CXD75_RS13640	COG1012	belongs to the aldehyde dehydrogenase family
CXD75_RS13660	COG2151	metal-sulfur cluster biosynthetic enzyme
CXD75_RS13665	COG3396	Phenylacetate-CoA oxygenase
CXD75_RS13670	COG3460	Phenylacetate-CoA oxygenase
CXD75_RS13675	COG3396	Phenylacetate-CoA oxygenase
CXD75_RS13680	COG3327	negative regulation of DNA-templated transcription, initiation
CXD75_RS13690	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CXD75_RS13695	COG0501	Belongs to the peptidase M48B family
CXD75_RS13700	COG1162	GTPase activity
CXD75_RS13715	COG0601	transmembrane transport
CXD75_RS13720	COG0747	negative chemotaxis
CXD75_RS13765	COG0668	transmembrane transport
CXD75_RS13770	COG0165	Argininosuccinate lyase
CXD75_RS13790	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CXD75_RS13795	COG0303	'Molybdopterin
CXD75_RS13800	COG0521	Mo-molybdopterin cofactor biosynthetic process
CXD75_RS13815	COG0315	cyclic pyranopterin monophosphate synthase activity
CXD75_RS13825	COG0412	Dienelactone hydrolase
CXD75_RS13835	COG0678	peroxiredoxin activity
CXD75_RS13845	COG0697	spore germination
CXD75_RS13850	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CXD75_RS13875	COG0789	Transcriptional regulator
CXD75_RS13895	COG1028	Short-chain dehydrogenase reductase Sdr
CXD75_RS13905	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CXD75_RS13910	COG1845	cytochrome c oxidase, subunit III
CXD75_RS13915	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CXD75_RS13925	COG0477	Major facilitator Superfamily
CXD75_RS13960	COG1309	transcriptional regulator
CXD75_RS13965	COG2271	Major facilitator Superfamily
CXD75_RS14000	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CXD75_RS14000	COG0506	proline dehydrogenase activity
CXD75_RS14000	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CXD75_RS14010	COG3008	intermembrane lipid transfer
CXD75_RS14010	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CXD75_RS14015	COG2995	paraquat-inducible protein a
CXD75_RS14020	COG0542	response to heat
CXD75_RS14025	COG4953	penicillin-binding protein 1C
CXD75_RS14035	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CXD75_RS14040	COG1278	Cold shock
CXD75_RS14050	COG0183	Belongs to the thiolase family
CXD75_RS14055	COG0038	chloride channel
CXD75_RS14060	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CXD75_RS14065	COG1570	exodeoxyribonuclease VII activity
CXD75_RS14075	COG0811	peptide transport
CXD75_RS14080	COG0848	biopolymer transport protein
CXD75_RS14085	COG1663	tetraacyldisaccharide 4'-kinase activity
CXD75_RS14090	COG2835	tetraacyldisaccharide 4'-kinase activity
CXD75_RS14095	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CXD75_RS14100	COG0563	adenylate kinase activity
CXD75_RS14110	COG0728	peptidoglycan biosynthetic process
CXD75_RS14120	COG0268	Binds directly to 16S ribosomal RNA
CXD75_RS14155	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CXD75_RS14180	COG0436	Aminotransferase
CXD75_RS14185	COG3737	Protein of unknown function (DUF498/DUF598)
CXD75_RS14190	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CXD75_RS14195	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CXD75_RS14200	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CXD75_RS14210	COG0305	Participates in initiation and elongation during chromosome replication
CXD75_RS14220	COG0359	binds to the 23S rRNA
CXD75_RS14225	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CXD75_RS14230	COG2965	DNA replication, synthesis of RNA primer
CXD75_RS14235	COG0360	Binds together with S18 to 16S ribosomal RNA
CXD75_RS14240	COG1469	GTP cyclohydrolase I activity
CXD75_RS14245	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CXD75_RS14250	COG0142	geranyltranstransferase activity
CXD75_RS14255	COG1722	exodeoxyribonuclease VII activity
CXD75_RS14265	COG3181	Tripartite tricarboxylate transporter family receptor
CXD75_RS14285	COG2239	Acts as a magnesium transporter
CXD75_RS14295	COG2855	membrane
CXD75_RS14305	COG1473	amidohydrolase
CXD75_RS14310	COG0318	PFAM AMP-dependent synthetase and ligase
CXD75_RS14335	COG1501	Belongs to the glycosyl hydrolase 31 family
CXD75_RS14340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CXD75_RS14345	COG2011	ABC-type metal ion transport system permease component
CXD75_RS14365	COG1454	alcohol dehydrogenase
CXD75_RS14395	COG2186	Transcriptional regulator
CXD75_RS14400	COG3181	Tripartite tricarboxylate transporter family receptor
CXD75_RS14420	COG1175	transmembrane transport
CXD75_RS14425	COG0395	ABC-type sugar transport system, permease component
CXD75_RS14430	COG3842	ATPase activity
CXD75_RS14445	COG1653	transport
CXD75_RS14465	COG2818	Glycosylase
CXD75_RS14470	COG2982	Protein involved in outer membrane biogenesis
CXD75_RS14480	COG1309	transcriptional regulator
CXD75_RS14485	COG1028	Short-chain dehydrogenase reductase Sdr
CXD75_RS14545	COG0583	DNA-binding transcription factor activity
CXD75_RS14550	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CXD75_RS14555	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CXD75_RS14570	COG1028	Short-chain dehydrogenase reductase Sdr
CXD75_RS14575	COG0477	Major facilitator Superfamily
CXD75_RS14585	COG0583	DNA-binding transcription factor activity
CXD75_RS14590	COG1448	Aminotransferase
CXD75_RS14595	COG1418	mRNA catabolic process
CXD75_RS14620	COG1063	alcohol dehydrogenase
CXD75_RS14640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD75_RS14650	COG0318	PFAM AMP-dependent synthetase and ligase
CXD75_RS14660	COG1522	sequence-specific DNA binding
CXD75_RS14665	COG3181	Tripartite tricarboxylate transporter family receptor
CXD75_RS14670	COG0307	riboflavin synthase, alpha
CXD75_RS14675	COG0154	amidase activity
CXD75_RS14695	COG2807	transmembrane transport
CXD75_RS14700	COG0590	tRNA wobble adenosine to inosine editing
CXD75_RS14710	COG0583	DNA-binding transcription factor activity
CXD75_RS14745	COG0559	Belongs to the binding-protein-dependent transport system permease family
CXD75_RS14750	COG0251	oxidation-reduction process
CXD75_RS14755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CXD75_RS14765	COG1414	Transcriptional regulator
CXD75_RS14770	COG1028	Short-chain dehydrogenase reductase Sdr
CXD75_RS14785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD75_RS14800	COG1024	Enoyl-CoA hydratase
CXD75_RS14805	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD75_RS14810	COG0154	amidase activity
CXD75_RS14850	COG3909	cytochrome
CXD75_RS14855	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CXD75_RS14860	COG0625	glutathione transferase activity
CXD75_RS14865	COG0730	response to heat
CXD75_RS14870	COG0482	sulfurtransferase activity
CXD75_RS14875	COG0583	DNA-binding transcription factor activity
CXD75_RS14915	COG2819	hydrolase of the alpha beta superfamily
CXD75_RS14920	COG0247	lactate metabolic process
CXD75_RS14925	COG0277	FAD linked oxidase domain protein
CXD75_RS14930	COG0277	FAD linked oxidase domain protein
CXD75_RS14935	COG0277	FAD linked oxidase domain protein
CXD75_RS14940	COG3064	Membrane
CXD75_RS14940	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CXD75_RS14940	COG3064	Membrane
CXD75_RS14940	COG3210	domain, Protein
CXD75_RS14940	COG3210	domain, Protein
CXD75_RS14940	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CXD75_RS14945	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CXD75_RS14950	COG0312	modulator of DNA gyrase
CXD75_RS14985	COG1666	GTP binding
CXD75_RS15030	COG3220	belongs to the UPF0276 family
CXD75_RS15050	COG0640	Transcriptional regulator
CXD75_RS15055	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CXD75_RS15060	COG1845	cytochrome c oxidase, subunit III
CXD75_RS15065	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CXD75_RS15075	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CXD75_RS15110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD75_RS15115	COG0583	DNA-binding transcription factor activity
CXD75_RS15150	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CXD75_RS15150	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CXD75_RS15165	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CXD75_RS15170	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CXD75_RS15180	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CXD75_RS15195	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CXD75_RS15200	COG0316	Belongs to the HesB IscA family
CXD75_RS15210	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CXD75_RS15215	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CXD75_RS15220	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CXD75_RS15225	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CXD75_RS15230	COG0312	modulator of DNA gyrase
CXD75_RS15235	COG3028	Belongs to the UPF0307 family
CXD75_RS15250	COG1116	anion transmembrane transporter activity
CXD75_RS15255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD75_RS15260	COG1335	isochorismatase
CXD75_RS15265	COG0346	lactoylglutathione lyase activity
CXD75_RS15270	COG0513	Belongs to the DEAD box helicase family
CXD75_RS15275	COG3069	C4-dicarboxylate transmembrane transporter activity
CXD75_RS15280	COG1802	Transcriptional regulator
CXD75_RS15295	COG1042	CoA-binding domain protein
CXD75_RS15295	COG0045	succinate-CoA ligase (ADP-forming) activity
CXD75_RS15295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CXD75_RS15300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CXD75_RS15315	COG1522	sequence-specific DNA binding
CXD75_RS15350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXD75_RS15355	COG1696	Membrane protein involved in D-alanine export
CXD75_RS15380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CXD75_RS15395	COG0439	Biotin carboxylase
CXD75_RS15400	COG0511	ligase activity, forming carbon-carbon bonds
CXD75_RS15405	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CXD75_RS15410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CXD75_RS15415	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CXD75_RS15420	COG3150	esterase
CXD75_RS15425	COG0557	exoribonuclease II activity
CXD75_RS15435	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CXD75_RS15455	COG1522	sequence-specific DNA binding
CXD75_RS15460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD75_RS15465	COG1028	Short-chain dehydrogenase reductase Sdr
CXD75_RS15485	COG0653	protein targeting
CXD75_RS15490	COG0739	heme binding
CXD75_RS15500	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CXD75_RS15505	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CXD75_RS15515	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CXD75_RS15520	COG1181	Belongs to the D-alanine--D-alanine ligase family
CXD75_RS15525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CXD75_RS15530	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CXD75_RS15540	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CXD75_RS15545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CXD75_RS15550	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CXD75_RS15560	COG3116	cell division
CXD75_RS15565	COG0275	rRNA processing
CXD75_RS15570	COG2001	Belongs to the MraZ family
CXD75_RS15580	COG0488	(ABC) transporter
CXD75_RS15585	COG0418	dihydroorotase activity
CXD75_RS15590	COG1473	amidohydrolase
CXD75_RS15640	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CXD75_RS15645	COG4654	Cytochrome c, class I
CXD75_RS15650	COG0129	dihydroxy-acid dehydratase activity
CXD75_RS15655	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CXD75_RS15705	COG2084	Dehydrogenase
CXD75_RS15720	COG2096	Adenosyltransferase
CXD75_RS15735	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CXD75_RS15740	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CXD75_RS15750	COG0523	cobalamin synthesis protein
CXD75_RS15755	COG0735	belongs to the Fur family
CXD75_RS15770	COG0803	Belongs to the bacterial solute-binding protein 9 family
CXD75_RS15780	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CXD75_RS15790	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CXD75_RS15800	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CXD75_RS15805	COG1560	Kdo2-lipid A biosynthetic process
CXD75_RS15815	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CXD75_RS15830	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CXD75_RS15835	COG1950	PFAM Membrane protein of
CXD75_RS15895	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CXD75_RS15900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXD75_RS15910	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CXD75_RS15915	COG0513	Belongs to the DEAD box helicase family
CXD75_RS15925	COG0617	tRNA 3'-terminal CCA addition
CXD75_RS15940	COG0477	Major facilitator Superfamily
CXD75_RS15950	COG0583	DNA-binding transcription factor activity
CXD75_RS15980	COG0405	Gamma-glutamyltransferase
CXD75_RS15990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD75_RS16020	COG1309	transcriptional regulator
CXD75_RS16035	COG0745	RESPONSE REGULATOR receiver
CXD75_RS16085	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CXD75_RS16110	COG0582	viral genome integration into host DNA
CXD75_RS16115	COG0012	GTP binding
CXD75_RS16125	COG0193	aminoacyl-tRNA hydrolase activity
CXD75_RS16130	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CXD75_RS16135	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CXD75_RS16145	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CXD75_RS16150	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CXD75_RS16160	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CXD75_RS16185	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CXD75_RS16195	COG1368	sulfuric ester hydrolase activity
CXD75_RS16200	COG0642	Histidine kinase
CXD75_RS16205	COG0745	RESPONSE REGULATOR receiver
CXD75_RS16210	COG0277	FAD linked oxidase domain protein
CXD75_RS16225	COG0166	Belongs to the GPI family
CXD75_RS16230	COG0438	transferase activity, transferring glycosyl groups
CXD75_RS16235	COG0438	transferase activity, transferring glycosyl groups
CXD75_RS16250	COG0438	transferase activity, transferring glycosyl groups
CXD75_RS16265	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CXD75_RS16270	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CXD75_RS16275	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CXD75_RS16285	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CXD75_RS16295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXD75_RS16300	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CXD75_RS16310	COG0747	negative chemotaxis
CXD75_RS16315	COG0601	transmembrane transport
CXD75_RS16320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD75_RS16340	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CXD75_RS16345	COG0830	nickel cation binding
CXD75_RS16355	COG0804	urea catabolic process
CXD75_RS16360	COG0832	Belongs to the urease beta subunit family
CXD75_RS16370	COG0831	urea catabolic process
CXD75_RS16375	COG0829	nickel cation binding
CXD75_RS16405	COG2188	Transcriptional regulator
CXD75_RS16430	COG2719	SpoVR family
CXD75_RS16435	COG2718	Belongs to the UPF0229 family
CXD75_RS16455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD75_RS16470	COG1960	acyl-CoA dehydrogenase activity
CXD75_RS16520	COG2030	dehydratase
CXD75_RS16570	COG0328	RNA-DNA hybrid ribonuclease activity
CXD75_RS16575	COG2226	methyltransferase
CXD75_RS16580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CXD75_RS16585	COG1388	LysM domain
CXD75_RS16585	COG0741	lytic transglycosylase activity
CXD75_RS16605	COG2979	Protein of unknown function (DUF533)
CXD75_RS16640	COG1271	oxidase subunit
CXD75_RS16645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CXD75_RS16650	COG0850	regulation of cytokinetic process
CXD75_RS16655	COG2894	cell division
CXD75_RS16660	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CXD75_RS16695	COG0601	transmembrane transport
CXD75_RS16705	COG1215	transferase activity, transferring glycosyl groups
CXD75_RS16720	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CXD75_RS16730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CXD75_RS16750	COG0318	PFAM AMP-dependent synthetase and ligase
CXD75_RS16755	COG2188	Transcriptional regulator
CXD75_RS16760	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CXD75_RS16765	COG2814	Major facilitator Superfamily
CXD75_RS16775	COG0259	pyridoxamine-phosphate oxidase activity
CXD75_RS16780	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CXD75_RS16795	COG0583	DNA-binding transcription factor activity
CXD75_RS16820	COG0134	indole-3-glycerol-phosphate synthase activity
CXD75_RS16825	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CXD75_RS16830	COG0512	Glutamine amidotransferase of anthranilate synthase
CXD75_RS16840	COG0546	phosphoglycolate phosphatase activity
CXD75_RS16845	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CXD75_RS16850	COG2967	ApaG domain
CXD75_RS16855	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CXD75_RS16860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CXD75_RS16865	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CXD75_RS16870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CXD75_RS16880	COG0037	tRNA processing
CXD75_RS16890	COG3634	alkyl hydroperoxide reductase activity
CXD75_RS16895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CXD75_RS16900	COG1024	Enoyl-CoA hydratase
CXD75_RS16925	COG0356	it plays a direct role in the translocation of protons across the membrane
CXD75_RS16935	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CXD75_RS16940	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CXD75_RS16945	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CXD75_RS16950	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CXD75_RS16955	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CXD75_RS16960	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CXD75_RS16970	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CXD75_RS16975	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CXD75_RS16980	COG0210	DNA helicase
CXD75_RS16990	COG2195	Cleaves the N-terminal amino acid of tripeptides
CXD75_RS17000	COG4172	Belongs to the ABC transporter superfamily
CXD75_RS17005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD75_RS17010	COG0601	transmembrane transport
CXD75_RS17030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CXD75_RS17035	COG1024	Enoyl-CoA hydratase
CXD75_RS17040	COG1024	Enoyl-CoA hydratase
CXD75_RS17095	COG2132	Multicopper oxidase
CXD75_RS17105	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXD75_RS17105	COG1024	Enoyl-CoA hydratase
CXD75_RS17115	COG1414	Transcriptional regulator
CXD75_RS17125	COG0154	amidase activity
CXD75_RS17155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXD75_RS17160	COG3568	Endonuclease Exonuclease Phosphatase
CXD75_RS17165	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CXD75_RS17200	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CXD75_RS17210	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CXD75_RS17225	COG1137	ATPase activity
CXD75_RS17240	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CXD75_RS17245	COG2010	Cytochrome c
CXD75_RS17245	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CXD75_RS17255	COG1660	Displays ATPase and GTPase activities
CXD75_RS17260	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CXD75_RS17295	COG3181	Tripartite tricarboxylate transporter family receptor
CXD75_RS17305	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CXD75_RS17310	COG2890	protein-(glutamine-N5) methyltransferase activity
CXD75_RS17315	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CXD75_RS17320	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CXD75_RS17370	COG1960	acyl-CoA dehydrogenase activity
CXD75_RS17380	COG0183	Belongs to the thiolase family
CXD75_RS17385	COG1522	sequence-specific DNA binding
CXD75_RS17390	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CXD75_RS17410	COG1024	Enoyl-CoA hydratase
CXD75_RS17425	COG0604	alcohol dehydrogenase
CXD75_RS17445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CXD75_RS17455	COG1960	acyl-CoA dehydrogenase activity
CXD75_RS17460	COG1960	acyl-CoA dehydrogenase activity
CXD75_RS17465	COG0277	FAD linked oxidase domain protein
CXD75_RS17475	COG3181	Tripartite tricarboxylate transporter family receptor
CXD75_RS17500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXD75_RS17510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD75_RS17515	COG3181	Tripartite tricarboxylate transporter family receptor
CXD75_RS17520	COG1960	acyl-CoA dehydrogenase activity
CXD75_RS17540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CXD75_RS17545	COG1024	Enoyl-CoA hydratase
CXD75_RS17550	COG1960	acyl-CoA dehydrogenase activity
CXD75_RS17570	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CXD75_RS17575	COG0022	dehydrogenase e1 component
CXD75_RS17580	COG1024	Enoyl-CoA hydratase
CXD75_RS17585	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXD75_RS17605	COG0683	leucine binding
CXD75_RS17610	COG0559	Belongs to the binding-protein-dependent transport system permease family
CXD75_RS17615	COG0411	ABC transporter
CXD75_RS17625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CXD75_RS17640	COG3181	Tripartite tricarboxylate transporter family receptor
CXD75_RS17670	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CXD75_RS17675	COG0793	Belongs to the peptidase S41A family
CXD75_RS17680	COG4942	peptidase
CXD75_RS17685	COG0588	phosphoglycerate mutase activity
CXD75_RS17690	COG1054	Belongs to the UPF0176 family
CXD75_RS17695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CXD75_RS17700	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CXD75_RS17705	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CXD75_RS17710	COG3181	Tripartite tricarboxylate transporter family receptor
CXD75_RS17725	COG2226	methyltransferase
CXD75_RS17730	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CXD75_RS17745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD75_RS17750	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CXD75_RS17775	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CXD75_RS17800	COG1335	isochorismatase
CXD75_RS17805	COG2309	aminopeptidase activity
CXD75_RS17815	COG3473	Maleate cis-trans isomerase
CXD75_RS17825	COG2068	MobA-Related Protein
CXD75_RS17850	COG2204	response regulator
CXD75_RS17855	COG5000	phosphorelay sensor kinase activity
CXD75_RS17865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CXD75_RS17865	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CXD75_RS17875	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CXD75_RS17910	COG0583	DNA-binding transcription factor activity
CXD75_RS17930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXD75_RS17935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD75_RS17950	COG0758	DNA mediated transformation
CXD75_RS17955	COG1522	sequence-specific DNA binding
CXD75_RS17965	COG0242	peptide deformylase activity
CXD75_RS17980	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CXD75_RS17990	COG0546	phosphoglycolate phosphatase activity
CXD75_RS18010	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CXD75_RS18015	COG1942	4-Oxalocrotonate Tautomerase
CXD75_RS18020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD75_RS18045	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CXD75_RS18065	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CXD75_RS18070	COG1024	Enoyl-CoA hydratase
CXD75_RS18075	COG1414	Transcriptional regulator
CXD75_RS18080	COG0318	PFAM AMP-dependent synthetase and ligase
CXD75_RS18085	COG3181	Tripartite tricarboxylate transporter family receptor
CXD75_RS18130	COG3422	double-strand break repair
CXD75_RS18135	COG0330	HflC and HflK could
CXD75_RS18145	COG0251	oxidation-reduction process
CXD75_RS18195	COG3723	Recombinational DNA repair protein, rece pathway
CXD75_RS18230	COG0582	viral genome integration into host DNA
CXD75_RS18270	COG0706	membrane insertase activity
CXD75_RS18275	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CXD75_RS18280	COG0594	ribonuclease P activity
CXD75_RS18285	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CXD75_RS18290	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CXD75_RS18305	COG1414	Transcriptional regulator
CXD75_RS18310	COG0154	amidase activity
CXD75_RS18325	COG1304	FMN binding
CXD75_RS18375	COG0183	Belongs to the thiolase family
CXD75_RS18380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CXD75_RS18395	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CXD75_RS18400	COG3181	Tripartite tricarboxylate transporter family receptor
CXD75_RS18410	COG2358	TRAP transporter, solute receptor (TAXI family
CXD75_RS18420	COG1629	transport
CXD75_RS18425	COG2922	Belongs to the Smg family
CXD75_RS18450	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CXD75_RS18455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD75_RS18460	COG1028	Short-chain dehydrogenase reductase Sdr
CXD75_RS18465	COG1012	belongs to the aldehyde dehydrogenase family
CXD75_RS18475	COG0028	Belongs to the TPP enzyme family
CXD75_RS18480	COG1522	sequence-specific DNA binding
CXD75_RS18485	COG3781	membrane
CXD75_RS18495	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CXD75_RS18515	COG4206	TonB-dependent receptor
CXD75_RS18520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CXD75_RS18525	COG2022	thiamine diphosphate biosynthetic process
CXD75_RS18530	COG0351	phosphomethylpyrimidine kinase
CXD75_RS18535	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CXD75_RS18550	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CXD75_RS18560	COG0628	permease
CXD75_RS18570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CXD75_RS18585	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CXD75_RS18590	COG0049	tRNA binding
CXD75_RS18595	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CXD75_RS18600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CXD75_RS18605	COG0051	transcription antitermination factor activity, RNA binding
CXD75_RS18610	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CXD75_RS18615	COG0088	Forms part of the polypeptide exit tunnel
CXD75_RS18620	COG0089	rRNA binding
CXD75_RS18625	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CXD75_RS18630	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CXD75_RS18635	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CXD75_RS18640	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CXD75_RS18645	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CXD75_RS18650	COG0255	Belongs to the universal ribosomal protein uL29 family
CXD75_RS18655	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CXD75_RS18675	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CXD75_RS18680	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CXD75_RS18685	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CXD75_RS18690	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CXD75_RS18695	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CXD75_RS18700	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CXD75_RS18705	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CXD75_RS18710	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CXD75_RS18715	COG1841	ribosomal large subunit assembly
CXD75_RS18720	COG0200	Binds to the 23S rRNA
CXD75_RS18725	COG0201	protein transport
CXD75_RS18730	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CXD75_RS18735	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CXD75_RS18740	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CXD75_RS18745	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CXD75_RS18750	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CXD75_RS18755	COG0202	RNA polymerase activity
CXD75_RS18760	COG0203	ribosomal protein L17
CXD75_RS18765	COG0537	adenosine 5'-monophosphoramidase activity
CXD75_RS18770	COG1324	tolerance protein
CXD75_RS18775	COG4232	protein-disulfide reductase activity
CXD75_RS18790	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CXD75_RS18800	COG1333	cytochrome c biogenesis protein
CXD75_RS18805	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CXD75_RS18820	COG1965	Belongs to the frataxin family
CXD75_RS18830	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CXD75_RS18835	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CXD75_RS18840	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CXD75_RS18855	COG2814	Major facilitator Superfamily
CXD75_RS18860	COG0629	single-stranded DNA binding
CXD75_RS18900	COG0402	S-adenosylhomocysteine deaminase activity
CXD75_RS18910	COG0438	transferase activity, transferring glycosyl groups
CXD75_RS18930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD75_RS18955	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CXD75_RS18980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXD75_RS18985	COG1956	GAF domain-containing protein
CXD75_RS18990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXD75_RS19005	COG1652	LysM domain
CXD75_RS19020	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CXD75_RS19035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CXD75_RS19065	COG3181	Tripartite tricarboxylate transporter family receptor
CXD75_RS19080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD75_RS19095	COG1024	Enoyl-CoA hydratase
CXD75_RS19110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD75_RS19115	COG1309	transcriptional regulator
CXD75_RS19120	COG2816	NAD+ diphosphatase activity
CXD75_RS19125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CXD75_RS19210	COG2814	Major facilitator Superfamily
CXD75_RS19215	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CXD75_RS19235	COG1999	signal sequence binding
CXD75_RS19240	COG0109	protoheme IX farnesyltransferase activity
CXD75_RS19280	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CXD75_RS19300	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CXD75_RS19305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CXD75_RS19315	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CXD75_RS19320	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CXD75_RS19330	COG0070	glutamate synthase
CXD75_RS19330	COG0069	glutamate synthase activity
CXD75_RS19330	COG0067	glutamate synthase
CXD75_RS19340	COG3047	cAMP biosynthetic process
CXD75_RS19350	COG1127	ABC transporter
CXD75_RS19355	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CXD75_RS19360	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CXD75_RS19365	COG2853	Lipoprotein
CXD75_RS19380	COG0842	Transport permease protein
CXD75_RS19390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CXD75_RS19395	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CXD75_RS19400	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CXD75_RS19405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CXD75_RS19410	COG0131	Imidazoleglycerol-phosphate dehydratase
CXD75_RS19415	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CXD75_RS19420	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CXD75_RS19425	COG0107	imidazoleglycerol-phosphate synthase activity
CXD75_RS19430	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CXD75_RS19435	COG0140	phosphoribosyl-ATP diphosphatase activity
CXD75_RS19440	COG0537	adenosine 5'-monophosphoramidase activity
CXD75_RS19445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CXD75_RS19450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CXD75_RS19465	COG3181	Tripartite tricarboxylate transporter family receptor
CXD75_RS19500	COG3702	type iv secretory pathway
CXD75_RS19505	COG3451	type IV secretory pathway VirB4
CXD75_RS19520	COG3736	Type IV secretory pathway, component VirB8
CXD75_RS19525	COG3504	Conjugal transfer protein
CXD75_RS19530	COG2948	multi-organism process
CXD75_RS19535	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
CXD75_RS19545	COG0697	spore germination
CXD75_RS19565	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CXD75_RS19570	COG0747	negative chemotaxis
CXD75_RS19575	COG0601	transmembrane transport
CXD75_RS19580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD75_RS19595	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CXD75_RS19605	COG0494	nUDIX hydrolase
CXD75_RS19650	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CXD75_RS19655	COG0237	dephospho-CoA kinase activity
CXD75_RS19660	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CXD75_RS19675	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CXD75_RS19680	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CXD75_RS19690	COG0477	Major facilitator Superfamily
CXD75_RS19695	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CXD75_RS19710	COG1126	abc transporter atp-binding protein
CXD75_RS19715	COG0765	amino acid transport
CXD75_RS19720	COG4597	amino acid ABC transporter
CXD75_RS19725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD75_RS19730	COG2884	Cell division ATP-binding protein ftsE
CXD75_RS19735	COG2177	Part of the ABC transporter FtsEX involved in
CXD75_RS19740	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CXD75_RS19750	COG1194	a g-specific adenine glycosylase
CXD75_RS19760	COG2226	methyltransferase
CXD75_RS19770	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD75_RS19775	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD75_RS19790	COG1024	Enoyl-CoA hydratase
CXD75_RS19810	COG1024	Enoyl-CoA hydratase
CXD75_RS19815	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD75_RS19830	COG0753	catalase activity
CXD75_RS19835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD75_RS19840	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CXD75_RS19850	COG2175	clavaminate synthase activity
CXD75_RS19855	COG1473	amidohydrolase
CXD75_RS19860	COG4608	Belongs to the ABC transporter superfamily
CXD75_RS19865	COG0444	Belongs to the ABC transporter superfamily
CXD75_RS19880	COG0747	negative chemotaxis
CXD75_RS19885	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CXD75_RS19920	COG0436	Aminotransferase
CXD75_RS19925	COG1278	Cold shock