locus-tag	class	description
CXD77_RS00005	COG0445	tRNA wobble uridine modification
CXD77_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
CXD77_RS00015	COG1192	Involved in chromosome partitioning
CXD77_RS00025	COG1475	DNA binding
CXD77_RS00050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CXD77_RS00060	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CXD77_RS00070	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CXD77_RS00075	COG0081	regulation of translation
CXD77_RS00080	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CXD77_RS00085	COG0222	ribosome binding
CXD77_RS00090	COG0085	RNA polymerase activity
CXD77_RS00095	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CXD77_RS00135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD77_RS00160	COG1024	Enoyl-CoA hydratase
CXD77_RS00180	COG0752	glycyl-tRNA synthetase alpha subunit
CXD77_RS00185	COG0751	glycine-tRNA ligase activity
CXD77_RS00190	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CXD77_RS00195	COG0204	Acyl-transferase
CXD77_RS00210	COG0242	peptide deformylase activity
CXD77_RS00250	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CXD77_RS00255	COG2813	Specifically methylates the guanine in position
CXD77_RS00255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CXD77_RS00270	COG2223	nitrite transmembrane transporter activity
CXD77_RS00280	COG1794	racemase activity, acting on amino acids and derivatives
CXD77_RS00285	COG1126	abc transporter atp-binding protein
CXD77_RS00290	COG0765	amino acid transport
CXD77_RS00295	COG0765	amino acid transport
CXD77_RS00300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD77_RS00365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CXD77_RS00395	COG0326	Molecular chaperone. Has ATPase activity
CXD77_RS00400	COG0625	glutathione transferase activity
CXD77_RS00415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CXD77_RS00420	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CXD77_RS00450	COG0438	transferase activity, transferring glycosyl groups
CXD77_RS00455	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CXD77_RS00460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CXD77_RS00490	COG0859	PFAM glycosyl transferase family 9
CXD77_RS00505	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CXD77_RS00515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CXD77_RS00520	COG1127	ABC transporter
CXD77_RS00540	COG1686	Belongs to the peptidase S11 family
CXD77_RS00550	COG2921	Belongs to the UPF0250 family
CXD77_RS00555	COG0321	lipoyl(octanoyl) transferase activity
CXD77_RS00560	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CXD77_RS00595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CXD77_RS00605	COG0018	arginyl-trna synthetase
CXD77_RS00625	COG0395	ABC-type sugar transport system, permease component
CXD77_RS00630	COG1175	transmembrane transport
CXD77_RS00635	COG1653	transport
CXD77_RS00640	COG3842	ATPase activity
CXD77_RS00645	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CXD77_RS00655	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CXD77_RS00675	COG1609	Transcriptional regulator
CXD77_RS00685	COG0154	amidase activity
CXD77_RS00690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CXD77_RS00700	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CXD77_RS00710	COG0583	DNA-binding transcription factor activity
CXD77_RS00730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CXD77_RS00745	COG1802	Transcriptional regulator
CXD77_RS00760	COG1024	Enoyl-CoA hydratase
CXD77_RS00770	COG3181	Tripartite tricarboxylate transporter family receptor
CXD77_RS00785	COG1984	allophanate hydrolase subunit 2
CXD77_RS00790	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CXD77_RS00800	COG0583	DNA-binding transcription factor activity
CXD77_RS00805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CXD77_RS00815	COG5002	protein histidine kinase activity
CXD77_RS00825	COG5002	protein histidine kinase activity
CXD77_RS00830	COG0745	RESPONSE REGULATOR receiver
CXD77_RS00835	COG2226	methyltransferase
CXD77_RS00850	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CXD77_RS00870	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CXD77_RS00880	COG0513	Belongs to the DEAD box helicase family
CXD77_RS00885	COG1280	lysine exporter protein (LysE YggA)
CXD77_RS00890	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CXD77_RS00930	COG1054	Belongs to the UPF0176 family
CXD77_RS00935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CXD77_RS00935	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CXD77_RS00945	COG0489	protein tyrosine kinase activity
CXD77_RS00960	COG0717	Belongs to the dCTP deaminase family
CXD77_RS00990	COG2081	HI0933 family
CXD77_RS01000	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CXD77_RS01010	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CXD77_RS01015	COG0509	glycine decarboxylation via glycine cleavage system
CXD77_RS01020	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CXD77_RS01020	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CXD77_RS01060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CXD77_RS01075	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CXD77_RS01085	COG1414	Transcriptional regulator
CXD77_RS01090	COG1028	Short-chain dehydrogenase reductase Sdr
CXD77_RS01095	COG2031	fatty acid transporter
CXD77_RS01100	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXD77_RS01110	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CXD77_RS01115	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CXD77_RS01125	COG4257	antibiotic catabolic process
CXD77_RS01150	COG1012	belongs to the aldehyde dehydrogenase family
CXD77_RS01155	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CXD77_RS01160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CXD77_RS01185	COG1028	Short-chain dehydrogenase reductase Sdr
CXD77_RS01195	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CXD77_RS01205	COG2188	Transcriptional regulator
CXD77_RS01210	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CXD77_RS01235	COG0617	tRNA 3'-terminal CCA addition
CXD77_RS01250	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CXD77_RS01255	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CXD77_RS01260	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CXD77_RS01265	COG0586	Pfam SNARE associated Golgi protein
CXD77_RS01270	COG0860	N-Acetylmuramoyl-L-alanine amidase
CXD77_RS01275	COG0802	atpase or kinase
CXD77_RS01280	COG0114	fumarate hydratase activity
CXD77_RS01290	COG3181	Tripartite tricarboxylate transporter family receptor
CXD77_RS01300	COG0405	Gamma-glutamyltransferase
CXD77_RS01305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD77_RS01340	COG1294	oxidase, subunit
CXD77_RS01350	COG4988	ABC transporter
CXD77_RS01355	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CXD77_RS01405	COG2969	positive regulation of protein catabolic process
CXD77_RS01410	COG0625	glutathione transferase activity
CXD77_RS01415	COG2857	Cytochrome c1
CXD77_RS01420	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CXD77_RS01425	COG0723	plastoquinol--plastocyanin reductase activity
CXD77_RS01430	COG1970	mechanosensitive ion channel activity
CXD77_RS01435	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CXD77_RS01450	COG2808	Putative FMN-binding domain
CXD77_RS01455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CXD77_RS01460	COG0747	negative chemotaxis
CXD77_RS01465	COG0657	acetylesterase activity
CXD77_RS01475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CXD77_RS01480	COG2207	Transcriptional regulator
CXD77_RS01485	COG0129	dihydroxy-acid dehydratase activity
CXD77_RS01490	COG2814	Major facilitator Superfamily
CXD77_RS01495	COG0583	DNA-binding transcription factor activity
CXD77_RS01505	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
CXD77_RS01575	COG1024	Enoyl-CoA hydratase
CXD77_RS01580	COG1960	acyl-CoA dehydrogenase activity
CXD77_RS01605	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CXD77_RS01610	COG0352	thiamine-phosphate diphosphorylase activity
CXD77_RS01625	COG1678	Uncharacterized ACR, COG1678
CXD77_RS01630	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CXD77_RS01635	COG0540	Belongs to the ATCase OTCase family
CXD77_RS01650	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CXD77_RS01660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CXD77_RS01695	COG1234	tRNA 3'-trailer cleavage
CXD77_RS01715	COG3064	Membrane
CXD77_RS01745	COG1683	Conserved Protein
CXD77_RS01750	COG1120	ATPase activity
CXD77_RS01755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXD77_RS01760	COG4558	Periplasmic binding protein
CXD77_RS01765	COG3720	iron ion transport
CXD77_RS01775	COG3712	iron ion homeostasis
CXD77_RS01780	COG1595	DNA-templated transcription, initiation
CXD77_RS01815	COG1802	Transcriptional regulator
CXD77_RS01825	COG3069	C4-dicarboxylate transmembrane transporter activity
CXD77_RS01835	COG1012	belongs to the aldehyde dehydrogenase family
CXD77_RS01870	COG2860	membrane
CXD77_RS01875	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CXD77_RS01880	COG0708	Exodeoxyribonuclease III
CXD77_RS01885	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CXD77_RS01890	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CXD77_RS01895	COG0154	amidase activity
CXD77_RS01900	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CXD77_RS01905	COG1077	Cell shape determining protein MreB Mrl
CXD77_RS01910	COG1792	Involved in formation and maintenance of cell shape
CXD77_RS01920	COG0768	penicillin binding
CXD77_RS01925	COG0772	Belongs to the SEDS family
CXD77_RS01930	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CXD77_RS01935	COG0471	metal ion transport
CXD77_RS01940	COG1309	transcriptional regulator
CXD77_RS01950	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CXD77_RS01965	COG2823	Periplasmic or secreted lipoprotein
CXD77_RS01970	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CXD77_RS01985	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CXD77_RS02005	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD77_RS02015	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD77_RS02035	COG0492	ferredoxin-NADP+ reductase activity
CXD77_RS02045	COG3181	Tripartite tricarboxylate transporter family receptor
CXD77_RS02050	COG1024	Enoyl-CoA hydratase
CXD77_RS02050	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXD77_RS02055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD77_RS02060	COG0028	Belongs to the TPP enzyme family
CXD77_RS02085	COG3181	Tripartite tricarboxylate transporter family receptor
CXD77_RS02100	COG0697	spore germination
CXD77_RS02130	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CXD77_RS02135	COG0463	Glycosyl transferase, family 2
CXD77_RS02150	COG0786	glutamate:sodium symporter activity
CXD77_RS02160	COG2031	fatty acid transporter
CXD77_RS02175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CXD77_RS02205	COG3181	Tripartite tricarboxylate transporter family receptor
CXD77_RS02215	COG0277	FAD linked oxidase domain protein
CXD77_RS02220	COG1960	acyl-CoA dehydrogenase activity
CXD77_RS02225	COG1960	acyl-CoA dehydrogenase activity
CXD77_RS02235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CXD77_RS02250	COG2072	flavoprotein involved in K transport
CXD77_RS02255	COG0604	alcohol dehydrogenase
CXD77_RS02270	COG1024	Enoyl-CoA hydratase
CXD77_RS02290	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CXD77_RS02295	COG1522	sequence-specific DNA binding
CXD77_RS02300	COG0183	Belongs to the thiolase family
CXD77_RS02310	COG1960	acyl-CoA dehydrogenase activity
CXD77_RS02350	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CXD77_RS02355	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CXD77_RS02360	COG2890	protein-(glutamine-N5) methyltransferase activity
CXD77_RS02365	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CXD77_RS02375	COG3181	Tripartite tricarboxylate transporter family receptor
CXD77_RS02410	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CXD77_RS02415	COG1660	Displays ATPase and GTPase activities
CXD77_RS02425	COG2010	Cytochrome c
CXD77_RS02425	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CXD77_RS02430	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CXD77_RS02445	COG1137	ATPase activity
CXD77_RS02460	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CXD77_RS02470	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CXD77_RS02505	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CXD77_RS02510	COG3568	Endonuclease Exonuclease Phosphatase
CXD77_RS02515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXD77_RS02545	COG0154	amidase activity
CXD77_RS02555	COG1414	Transcriptional regulator
CXD77_RS02565	COG1024	Enoyl-CoA hydratase
CXD77_RS02565	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXD77_RS02575	COG2132	Multicopper oxidase
CXD77_RS02630	COG1024	Enoyl-CoA hydratase
CXD77_RS02635	COG1024	Enoyl-CoA hydratase
CXD77_RS02640	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CXD77_RS02660	COG0601	transmembrane transport
CXD77_RS02665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD77_RS02670	COG4172	Belongs to the ABC transporter superfamily
CXD77_RS02680	COG2195	Cleaves the N-terminal amino acid of tripeptides
CXD77_RS02690	COG0210	DNA helicase
CXD77_RS02695	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CXD77_RS02700	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CXD77_RS02710	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CXD77_RS02715	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CXD77_RS02720	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CXD77_RS02725	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CXD77_RS02730	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CXD77_RS02735	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CXD77_RS02745	COG0356	it plays a direct role in the translocation of protons across the membrane
CXD77_RS02770	COG1024	Enoyl-CoA hydratase
CXD77_RS02775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CXD77_RS02780	COG3634	alkyl hydroperoxide reductase activity
CXD77_RS02790	COG0037	tRNA processing
CXD77_RS02800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CXD77_RS02805	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CXD77_RS02810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CXD77_RS02815	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CXD77_RS02820	COG2967	ApaG domain
CXD77_RS02825	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CXD77_RS02830	COG0546	phosphoglycolate phosphatase activity
CXD77_RS02840	COG0512	Glutamine amidotransferase of anthranilate synthase
CXD77_RS02845	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CXD77_RS02850	COG0134	indole-3-glycerol-phosphate synthase activity
CXD77_RS02880	COG0583	DNA-binding transcription factor activity
CXD77_RS02895	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CXD77_RS02900	COG0259	pyridoxamine-phosphate oxidase activity
CXD77_RS02910	COG2814	Major facilitator Superfamily
CXD77_RS02915	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CXD77_RS02920	COG2188	Transcriptional regulator
CXD77_RS02925	COG0318	PFAM AMP-dependent synthetase and ligase
CXD77_RS02945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CXD77_RS02955	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CXD77_RS02970	COG1215	transferase activity, transferring glycosyl groups
CXD77_RS02980	COG0601	transmembrane transport
CXD77_RS03015	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CXD77_RS03020	COG2894	cell division
CXD77_RS03025	COG0850	regulation of cytokinetic process
CXD77_RS03030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CXD77_RS03035	COG1271	oxidase subunit
CXD77_RS03070	COG2979	Protein of unknown function (DUF533)
CXD77_RS03090	COG0741	lytic transglycosylase activity
CXD77_RS03090	COG1388	LysM domain
CXD77_RS03095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CXD77_RS03100	COG2226	methyltransferase
CXD77_RS03105	COG0328	RNA-DNA hybrid ribonuclease activity
CXD77_RS03160	COG2030	dehydratase
CXD77_RS03210	COG1960	acyl-CoA dehydrogenase activity
CXD77_RS03225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD77_RS03245	COG2718	Belongs to the UPF0229 family
CXD77_RS03250	COG2719	SpoVR family
CXD77_RS03275	COG2188	Transcriptional regulator
CXD77_RS03305	COG0829	nickel cation binding
CXD77_RS03310	COG0831	urea catabolic process
CXD77_RS03320	COG0832	Belongs to the urease beta subunit family
CXD77_RS03325	COG0804	urea catabolic process
CXD77_RS03335	COG0830	nickel cation binding
CXD77_RS03340	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CXD77_RS03360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD77_RS03365	COG0601	transmembrane transport
CXD77_RS03370	COG0747	negative chemotaxis
CXD77_RS03380	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CXD77_RS03385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXD77_RS03395	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CXD77_RS03405	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CXD77_RS03410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CXD77_RS03415	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CXD77_RS03430	COG0438	transferase activity, transferring glycosyl groups
CXD77_RS03445	COG0438	transferase activity, transferring glycosyl groups
CXD77_RS03450	COG0438	transferase activity, transferring glycosyl groups
CXD77_RS03455	COG0166	Belongs to the GPI family
CXD77_RS03470	COG0277	FAD linked oxidase domain protein
CXD77_RS03475	COG0745	RESPONSE REGULATOR receiver
CXD77_RS03480	COG0642	Histidine kinase
CXD77_RS03485	COG1368	sulfuric ester hydrolase activity
CXD77_RS03495	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CXD77_RS03520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CXD77_RS03530	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CXD77_RS03535	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CXD77_RS03545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CXD77_RS03550	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CXD77_RS03555	COG0193	aminoacyl-tRNA hydrolase activity
CXD77_RS03565	COG0012	GTP binding
CXD77_RS03570	COG0582	viral genome integration into host DNA
CXD77_RS03595	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CXD77_RS03660	COG0745	RESPONSE REGULATOR receiver
CXD77_RS03675	COG1309	transcriptional regulator
CXD77_RS03705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD77_RS03715	COG0405	Gamma-glutamyltransferase
CXD77_RS03790	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CXD77_RS03795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXD77_RS03805	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CXD77_RS03810	COG0513	Belongs to the DEAD box helicase family
CXD77_RS03820	COG0617	tRNA 3'-terminal CCA addition
CXD77_RS03835	COG0477	Major facilitator Superfamily
CXD77_RS03845	COG0583	DNA-binding transcription factor activity
CXD77_RS03860	COG1950	PFAM Membrane protein of
CXD77_RS03865	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CXD77_RS03880	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CXD77_RS03890	COG1560	Kdo2-lipid A biosynthetic process
CXD77_RS03895	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CXD77_RS03905	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CXD77_RS03915	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CXD77_RS03925	COG0803	Belongs to the bacterial solute-binding protein 9 family
CXD77_RS03940	COG0735	belongs to the Fur family
CXD77_RS03945	COG0523	cobalamin synthesis protein
CXD77_RS03955	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CXD77_RS03960	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CXD77_RS03975	COG2096	Adenosyltransferase
CXD77_RS03995	COG2084	Dehydrogenase
CXD77_RS04045	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CXD77_RS04050	COG0129	dihydroxy-acid dehydratase activity
CXD77_RS04055	COG4654	Cytochrome c, class I
CXD77_RS04060	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CXD77_RS04110	COG1473	amidohydrolase
CXD77_RS04115	COG0418	dihydroorotase activity
CXD77_RS04120	COG0488	(ABC) transporter
CXD77_RS04130	COG2001	Belongs to the MraZ family
CXD77_RS04135	COG0275	rRNA processing
CXD77_RS04140	COG3116	cell division
CXD77_RS04150	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CXD77_RS04155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CXD77_RS04160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CXD77_RS04170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CXD77_RS04175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CXD77_RS04180	COG1181	Belongs to the D-alanine--D-alanine ligase family
CXD77_RS04185	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CXD77_RS04195	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CXD77_RS04200	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CXD77_RS04210	COG0739	heme binding
CXD77_RS04215	COG0653	protein targeting
CXD77_RS04235	COG1028	Short-chain dehydrogenase reductase Sdr
CXD77_RS04240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD77_RS04245	COG1522	sequence-specific DNA binding
CXD77_RS04265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CXD77_RS04275	COG0557	exoribonuclease II activity
CXD77_RS04280	COG3150	esterase
CXD77_RS04285	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CXD77_RS04290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CXD77_RS04295	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CXD77_RS04300	COG0511	ligase activity, forming carbon-carbon bonds
CXD77_RS04305	COG0439	Biotin carboxylase
CXD77_RS04320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CXD77_RS04345	COG1696	Membrane protein involved in D-alanine export
CXD77_RS04350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXD77_RS04385	COG1522	sequence-specific DNA binding
CXD77_RS04400	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CXD77_RS04405	COG0045	succinate-CoA ligase (ADP-forming) activity
CXD77_RS04405	COG1042	CoA-binding domain protein
CXD77_RS04405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CXD77_RS04420	COG1802	Transcriptional regulator
CXD77_RS04425	COG3069	C4-dicarboxylate transmembrane transporter activity
CXD77_RS04430	COG0513	Belongs to the DEAD box helicase family
CXD77_RS04435	COG0346	lactoylglutathione lyase activity
CXD77_RS04440	COG1335	isochorismatase
CXD77_RS04445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD77_RS04450	COG1116	anion transmembrane transporter activity
CXD77_RS04465	COG3028	Belongs to the UPF0307 family
CXD77_RS04470	COG0312	modulator of DNA gyrase
CXD77_RS04475	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CXD77_RS04480	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CXD77_RS04485	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CXD77_RS04490	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CXD77_RS04500	COG0316	Belongs to the HesB IscA family
CXD77_RS04505	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CXD77_RS04520	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CXD77_RS04530	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CXD77_RS04535	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CXD77_RS04550	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CXD77_RS04550	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CXD77_RS04585	COG0583	DNA-binding transcription factor activity
CXD77_RS04590	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD77_RS04625	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CXD77_RS04635	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CXD77_RS04640	COG1845	cytochrome c oxidase, subunit III
CXD77_RS04645	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CXD77_RS04650	COG0640	Transcriptional regulator
CXD77_RS04670	COG3220	belongs to the UPF0276 family
CXD77_RS04715	COG1666	GTP binding
CXD77_RS04750	COG0312	modulator of DNA gyrase
CXD77_RS04755	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CXD77_RS04760	COG3210	domain, Protein
CXD77_RS04760	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CXD77_RS04760	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CXD77_RS04760	COG3210	domain, Protein
CXD77_RS04760	COG3064	Membrane
CXD77_RS04760	COG3064	Membrane
CXD77_RS04765	COG0277	FAD linked oxidase domain protein
CXD77_RS04770	COG0277	FAD linked oxidase domain protein
CXD77_RS04775	COG0277	FAD linked oxidase domain protein
CXD77_RS04780	COG0247	lactate metabolic process
CXD77_RS04785	COG2819	hydrolase of the alpha beta superfamily
CXD77_RS04825	COG0583	DNA-binding transcription factor activity
CXD77_RS04830	COG0482	sulfurtransferase activity
CXD77_RS04835	COG0730	response to heat
CXD77_RS04840	COG0625	glutathione transferase activity
CXD77_RS04845	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CXD77_RS04850	COG3909	cytochrome
CXD77_RS04890	COG0154	amidase activity
CXD77_RS04895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD77_RS04900	COG1024	Enoyl-CoA hydratase
CXD77_RS04915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD77_RS04930	COG1028	Short-chain dehydrogenase reductase Sdr
CXD77_RS04935	COG1414	Transcriptional regulator
CXD77_RS04945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CXD77_RS04950	COG0251	oxidation-reduction process
CXD77_RS04955	COG0559	Belongs to the binding-protein-dependent transport system permease family
CXD77_RS04990	COG0583	DNA-binding transcription factor activity
CXD77_RS05000	COG0590	tRNA wobble adenosine to inosine editing
CXD77_RS05005	COG2807	transmembrane transport
CXD77_RS05025	COG0154	amidase activity
CXD77_RS05030	COG0307	riboflavin synthase, alpha
CXD77_RS05035	COG3181	Tripartite tricarboxylate transporter family receptor
CXD77_RS05040	COG1522	sequence-specific DNA binding
CXD77_RS05050	COG0318	PFAM AMP-dependent synthetase and ligase
CXD77_RS05060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD77_RS05080	COG1063	alcohol dehydrogenase
CXD77_RS05105	COG1418	mRNA catabolic process
CXD77_RS05110	COG1448	Aminotransferase
CXD77_RS05115	COG0583	DNA-binding transcription factor activity
CXD77_RS05125	COG0477	Major facilitator Superfamily
CXD77_RS05130	COG1028	Short-chain dehydrogenase reductase Sdr
CXD77_RS05145	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CXD77_RS05150	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CXD77_RS05155	COG0583	DNA-binding transcription factor activity
CXD77_RS05215	COG1028	Short-chain dehydrogenase reductase Sdr
CXD77_RS05220	COG1309	transcriptional regulator
CXD77_RS05230	COG2982	Protein involved in outer membrane biogenesis
CXD77_RS05235	COG2818	Glycosylase
CXD77_RS05255	COG1653	transport
CXD77_RS05270	COG3842	ATPase activity
CXD77_RS05275	COG0395	ABC-type sugar transport system, permease component
CXD77_RS05280	COG1175	transmembrane transport
CXD77_RS05300	COG3181	Tripartite tricarboxylate transporter family receptor
CXD77_RS05305	COG2186	Transcriptional regulator
CXD77_RS05345	COG1454	alcohol dehydrogenase
CXD77_RS05365	COG2011	ABC-type metal ion transport system permease component
CXD77_RS05370	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CXD77_RS05375	COG1501	Belongs to the glycosyl hydrolase 31 family
CXD77_RS05400	COG0318	PFAM AMP-dependent synthetase and ligase
CXD77_RS05405	COG1473	amidohydrolase
CXD77_RS05415	COG2855	membrane
CXD77_RS05425	COG2239	Acts as a magnesium transporter
CXD77_RS05445	COG3181	Tripartite tricarboxylate transporter family receptor
CXD77_RS05455	COG1722	exodeoxyribonuclease VII activity
CXD77_RS05460	COG0142	geranyltranstransferase activity
CXD77_RS05465	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CXD77_RS05470	COG1469	GTP cyclohydrolase I activity
CXD77_RS05475	COG0360	Binds together with S18 to 16S ribosomal RNA
CXD77_RS05480	COG2965	DNA replication, synthesis of RNA primer
CXD77_RS05485	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CXD77_RS05490	COG0359	binds to the 23S rRNA
CXD77_RS05500	COG0305	Participates in initiation and elongation during chromosome replication
CXD77_RS05510	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CXD77_RS05520	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CXD77_RS05525	COG3737	Protein of unknown function (DUF498/DUF598)
CXD77_RS05530	COG0436	Aminotransferase
CXD77_RS05555	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CXD77_RS05590	COG0268	Binds directly to 16S ribosomal RNA
CXD77_RS05600	COG0728	peptidoglycan biosynthetic process
CXD77_RS05610	COG0563	adenylate kinase activity
CXD77_RS05615	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CXD77_RS05620	COG2835	tetraacyldisaccharide 4'-kinase activity
CXD77_RS05625	COG1663	tetraacyldisaccharide 4'-kinase activity
CXD77_RS05630	COG0848	biopolymer transport protein
CXD77_RS05635	COG0811	peptide transport
CXD77_RS05645	COG1570	exodeoxyribonuclease VII activity
CXD77_RS05650	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CXD77_RS05655	COG0038	chloride channel
CXD77_RS05660	COG0183	Belongs to the thiolase family
CXD77_RS05670	COG1278	Cold shock
CXD77_RS05675	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CXD77_RS05685	COG4953	penicillin-binding protein 1C
CXD77_RS05690	COG0542	response to heat
CXD77_RS05695	COG2995	paraquat-inducible protein a
CXD77_RS05700	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CXD77_RS05700	COG3008	intermembrane lipid transfer
CXD77_RS05710	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CXD77_RS05710	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CXD77_RS05710	COG0506	proline dehydrogenase activity
CXD77_RS05745	COG2271	Major facilitator Superfamily
CXD77_RS05750	COG1309	transcriptional regulator
CXD77_RS05785	COG0477	Major facilitator Superfamily
CXD77_RS05795	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CXD77_RS05800	COG1845	cytochrome c oxidase, subunit III
CXD77_RS05805	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CXD77_RS05815	COG1028	Short-chain dehydrogenase reductase Sdr
CXD77_RS05835	COG0789	Transcriptional regulator
CXD77_RS05860	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CXD77_RS05865	COG0697	spore germination
CXD77_RS05875	COG0678	peroxiredoxin activity
CXD77_RS05885	COG0412	Dienelactone hydrolase
CXD77_RS05895	COG0315	cyclic pyranopterin monophosphate synthase activity
CXD77_RS05910	COG0521	Mo-molybdopterin cofactor biosynthetic process
CXD77_RS05915	COG0303	'Molybdopterin
CXD77_RS05920	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CXD77_RS05940	COG0165	Argininosuccinate lyase
CXD77_RS05945	COG0668	transmembrane transport
CXD77_RS05990	COG0747	negative chemotaxis
CXD77_RS05995	COG0601	transmembrane transport
CXD77_RS06010	COG1162	GTPase activity
CXD77_RS06015	COG0501	Belongs to the peptidase M48B family
CXD77_RS06020	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CXD77_RS06030	COG3327	negative regulation of DNA-templated transcription, initiation
CXD77_RS06035	COG3396	Phenylacetate-CoA oxygenase
CXD77_RS06040	COG3460	Phenylacetate-CoA oxygenase
CXD77_RS06045	COG3396	Phenylacetate-CoA oxygenase
CXD77_RS06050	COG2151	metal-sulfur cluster biosynthetic enzyme
CXD77_RS06070	COG1012	belongs to the aldehyde dehydrogenase family
CXD77_RS06075	COG1024	Enoyl-CoA hydratase
CXD77_RS06080	COG2050	protein possibly involved in aromatic compounds catabolism
CXD77_RS06090	COG3539	Fimbrial protein
CXD77_RS06110	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CXD77_RS06115	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CXD77_RS06115	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CXD77_RS06120	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CXD77_RS06125	COG0047	phosphoribosylformylglycinamidine synthase activity
CXD77_RS06125	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CXD77_RS06160	COG0235	Class ii aldolase
CXD77_RS06165	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CXD77_RS06170	COG0720	synthase
CXD77_RS06175	COG0602	queuosine metabolic process
CXD77_RS06200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXD77_RS06235	COG3181	Tripartite tricarboxylate transporter family receptor
CXD77_RS06260	COG3842	ATPase activity
CXD77_RS06270	COG0395	ABC-type sugar transport system, permease component
CXD77_RS06300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD77_RS06305	COG0420	3'-5' exonuclease activity
CXD77_RS06350	COG0519	Catalyzes the synthesis of GMP from XMP
CXD77_RS06350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CXD77_RS06365	COG3550	peptidyl-serine autophosphorylation
CXD77_RS06375	COG0477	Major facilitator Superfamily
CXD77_RS06390	COG1228	amidohydrolase
CXD77_RS06400	COG1116	anion transmembrane transporter activity
CXD77_RS06405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD77_RS06440	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CXD77_RS06460	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CXD77_RS06490	COG2814	Major facilitator Superfamily
CXD77_RS06505	COG1280	lysine exporter protein (LysE YggA)
CXD77_RS06525	COG0747	negative chemotaxis
CXD77_RS06530	COG0601	transmembrane transport
CXD77_RS06535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD77_RS06540	COG4172	Belongs to the ABC transporter superfamily
CXD77_RS06545	COG1609	Transcriptional regulator
CXD77_RS06575	COG0586	Pfam SNARE associated Golgi protein
CXD77_RS06590	COG0500	methyltransferase
CXD77_RS06610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXD77_RS06620	COG0756	dUTP diphosphatase activity
CXD77_RS06630	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CXD77_RS06635	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CXD77_RS06640	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CXD77_RS06645	COG0072	phenylalanine-tRNA ligase activity
CXD77_RS06645	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CXD77_RS06650	COG0776	regulation of translation
CXD77_RS06715	COG0540	Belongs to the ATCase OTCase family
CXD77_RS06720	COG2974	May be involved in recombination
CXD77_RS06730	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD77_RS06735	COG0583	DNA-binding transcription factor activity
CXD77_RS06755	COG1028	Short-chain dehydrogenase reductase Sdr
CXD77_RS06770	COG3842	ATPase activity
CXD77_RS06775	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXD77_RS06775	COG1024	Enoyl-CoA hydratase
CXD77_RS06795	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CXD77_RS06800	COG2137	regulation of response to DNA damage stimulus
CXD77_RS06810	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CXD77_RS06820	COG0045	succinate-CoA ligase (ADP-forming) activity
CXD77_RS06825	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CXD77_RS06830	COG0861	Integral membrane protein TerC family
CXD77_RS06835	COG0861	Integral membrane protein TerC family
CXD77_RS06840	COG0181	hydroxymethylbilane synthase activity
CXD77_RS06900	COG4964	Belongs to the GSP D family
CXD77_RS06925	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CXD77_RS06935	COG0583	DNA-binding transcription factor activity
CXD77_RS06945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD77_RS06950	COG4311	Sarcosine oxidase, delta subunit
CXD77_RS06955	COG0446	pyridine nucleotide-disulphide oxidoreductase
CXD77_RS06955	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CXD77_RS06990	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CXD77_RS06995	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CXD77_RS07000	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CXD77_RS07005	COG0735	belongs to the Fur family
CXD77_RS07010	COG0497	DNA recombination
CXD77_RS07015	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CXD77_RS07020	COG1420	regulation of RNA biosynthetic process
CXD77_RS07025	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CXD77_RS07035	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CXD77_RS07045	COG0443	Heat shock 70 kDa protein
CXD77_RS07055	COG0612	Peptidase, M16
CXD77_RS07075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CXD77_RS07120	COG0745	RESPONSE REGULATOR receiver
CXD77_RS07130	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CXD77_RS07135	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CXD77_RS07140	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CXD77_RS07155	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CXD77_RS07175	COG1193	negative regulation of DNA recombination
CXD77_RS07180	COG0492	ferredoxin-NADP+ reductase activity
CXD77_RS07185	COG1674	ftsk spoiiie
CXD77_RS07190	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CXD77_RS07195	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CXD77_RS07200	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CXD77_RS07225	COG3706	GGDEF domain
CXD77_RS07245	COG2814	Major facilitator Superfamily
CXD77_RS07275	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CXD77_RS07290	COG1028	Short-chain dehydrogenase reductase Sdr
CXD77_RS07300	COG3022	response to hydroperoxide
CXD77_RS07340	COG2197	response regulator
CXD77_RS07345	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CXD77_RS07350	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CXD77_RS07355	COG0189	ligase activity
CXD77_RS07365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CXD77_RS07370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CXD77_RS07385	COG2423	ornithine cyclodeaminase activity
CXD77_RS07395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD77_RS07400	COG0765	amino acid transport
CXD77_RS07405	COG0765	amino acid transport
CXD77_RS07410	COG1126	abc transporter atp-binding protein
CXD77_RS07465	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CXD77_RS07475	COG2944	sequence-specific DNA binding
CXD77_RS07485	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CXD77_RS07490	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CXD77_RS07495	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CXD77_RS07500	COG0009	L-threonylcarbamoyladenylate synthase
CXD77_RS07505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD77_RS07510	COG1414	Transcriptional regulator
CXD77_RS07525	COG0765	amino acid transport
CXD77_RS07530	COG1126	abc transporter atp-binding protein
CXD77_RS07535	COG0028	Belongs to the TPP enzyme family
CXD77_RS07550	COG0028	Belongs to the TPP enzyme family
CXD77_RS07555	COG0583	DNA-binding transcription factor activity
CXD77_RS07560	COG4974	Belongs to the 'phage' integrase family
CXD77_RS07565	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CXD77_RS07570	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CXD77_RS07585	COG1686	Belongs to the peptidase S11 family
CXD77_RS07595	COG2814	Major facilitator Superfamily
CXD77_RS07605	COG1074	ATP-dependent DNA helicase activity
CXD77_RS07615	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CXD77_RS07620	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CXD77_RS07625	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CXD77_RS07645	COG2321	neutral zinc metallopeptidase
CXD77_RS07650	COG0009	L-threonylcarbamoyladenylate synthase
CXD77_RS07700	COG3360	Dodecin
CXD77_RS07705	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CXD77_RS07710	COG2850	peptidyl-arginine hydroxylation
CXD77_RS07715	COG3539	Fimbrial protein
CXD77_RS07720	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CXD77_RS07725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXD77_RS07740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD77_RS07745	COG0765	amino acid transport
CXD77_RS07750	COG1126	abc transporter atp-binding protein
CXD77_RS07755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CXD77_RS07760	COG1758	RNA polymerase activity
CXD77_RS07765	COG0194	GDP metabolic process
CXD77_RS07770	COG3258	Cytochrome c
CXD77_RS07775	COG2863	cytochrome
CXD77_RS07780	COG1028	Short-chain dehydrogenase reductase Sdr
CXD77_RS07785	COG0791	NLP P60 protein
CXD77_RS07790	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CXD77_RS07810	COG1561	YicC-like family, N-terminal region
CXD77_RS07815	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CXD77_RS07835	COG2200	EAL domain
CXD77_RS07835	COG2199	diguanylate cyclase activity
CXD77_RS07840	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CXD77_RS07850	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CXD77_RS07855	COG0174	glutamine synthetase
CXD77_RS07865	COG2204	response regulator
CXD77_RS07870	COG0583	DNA-binding transcription factor activity
CXD77_RS07875	COG1741	Belongs to the pirin family
CXD77_RS07880	COG1741	Belongs to the pirin family
CXD77_RS07890	COG3842	ATPase activity
CXD77_RS07895	COG1178	ABC-type Fe3 transport system permease component
CXD77_RS07900	COG1840	ABC-type Fe3 transport system, periplasmic component
CXD77_RS07910	COG0583	DNA-binding transcription factor activity
CXD77_RS07920	COG0656	L-ascorbic acid biosynthetic process
CXD77_RS07935	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CXD77_RS07940	COG0583	DNA-binding transcription factor activity
CXD77_RS07955	COG0783	Belongs to the Dps family
CXD77_RS07975	COG0463	Glycosyl transferase, family 2
CXD77_RS07995	COG0438	transferase activity, transferring glycosyl groups
CXD77_RS08010	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CXD77_RS08035	COG0300	oxidoreductase activity
CXD77_RS08080	COG0861	Integral membrane protein TerC family
CXD77_RS08085	COG1028	Short-chain dehydrogenase reductase Sdr
CXD77_RS08105	COG0714	Associated with various cellular activities
CXD77_RS08140	COG3119	arylsulfatase activity
CXD77_RS08165	COG2197	response regulator
CXD77_RS08175	COG2944	sequence-specific DNA binding
CXD77_RS08185	COG0625	glutathione transferase activity
CXD77_RS08215	COG0179	Fumarylacetoacetate (FAA) hydrolase
CXD77_RS08220	COG1028	Short-chain dehydrogenase reductase Sdr
CXD77_RS08265	COG0431	NADPH-dependent FMN reductase
CXD77_RS08295	COG1028	Short-chain dehydrogenase reductase Sdr
CXD77_RS08300	COG0583	DNA-binding transcription factor activity
CXD77_RS08320	COG2111	Na H antiporter
CXD77_RS08320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CXD77_RS08325	COG1006	Multisubunit Na H antiporter MnhC subunit
CXD77_RS08330	COG0651	ATP synthesis coupled electron transport
CXD77_RS08335	COG1863	multisubunit Na H antiporter MnhE subunit
CXD77_RS08340	COG2212	antiporter activity
CXD77_RS08365	COG0590	tRNA wobble adenosine to inosine editing
CXD77_RS08370	COG1619	proteins homologs of microcin C7 resistance protein MccF
CXD77_RS08375	COG1024	Enoyl-CoA hydratase
CXD77_RS08390	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CXD77_RS08395	COG0488	(ABC) transporter
CXD77_RS08430	COG1017	nitric oxide dioxygenase activity
CXD77_RS08430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CXD77_RS08435	COG1959	2 iron, 2 sulfur cluster binding
CXD77_RS08440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD77_RS08460	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CXD77_RS08465	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CXD77_RS08470	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CXD77_RS08475	COG0084	hydrolase, TatD family'
CXD77_RS08490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD77_RS08500	COG1126	abc transporter atp-binding protein
CXD77_RS08510	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CXD77_RS08525	COG0028	Belongs to the TPP enzyme family
CXD77_RS08535	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CXD77_RS08535	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CXD77_RS08545	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CXD77_RS08595	COG4336	lyase activity
CXD77_RS08605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD77_RS08605	COG2205	protein histidine kinase activity
CXD77_RS08610	COG2197	response regulator
CXD77_RS08615	COG3210	domain, Protein
CXD77_RS08615	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CXD77_RS08615	COG3064	Membrane
CXD77_RS08625	COG3121	Chaperone
CXD77_RS08630	COG3188	usher protein
CXD77_RS08635	COG3539	Fimbrial protein
CXD77_RS08640	COG2831	hemolysin activation secretion protein
CXD77_RS08655	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CXD77_RS08705	COG0668	transmembrane transport
CXD77_RS08725	COG0483	inositol monophosphate 1-phosphatase activity
CXD77_RS08730	COG1253	flavin adenine dinucleotide binding
CXD77_RS08735	COG1968	undecaprenyl-diphosphatase activity
CXD77_RS08740	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CXD77_RS08755	COG0215	cysteine-tRNA ligase activity
CXD77_RS08765	COG0825	malonyl-CoA metabolic process
CXD77_RS08775	COG0037	tRNA processing
CXD77_RS08780	COG0527	aspartate kinase activity
CXD77_RS08805	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXD77_RS08810	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CXD77_RS08810	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CXD77_RS08825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CXD77_RS08830	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CXD77_RS08835	COG1028	Short-chain dehydrogenase reductase Sdr
CXD77_RS08845	COG0583	DNA-binding transcription factor activity
CXD77_RS08870	COG3842	ATPase activity
CXD77_RS08880	COG0446	pyridine nucleotide-disulphide oxidoreductase
CXD77_RS08880	COG1902	pentaerythritol trinitrate reductase activity
CXD77_RS08885	COG1414	Transcriptional regulator
CXD77_RS08890	COG1832	CoA-binding protein
CXD77_RS08900	COG0251	oxidation-reduction process
CXD77_RS08925	COG1902	pentaerythritol trinitrate reductase activity
CXD77_RS08935	COG1215	transferase activity, transferring glycosyl groups
CXD77_RS08940	COG1649	PFAM Uncharacterised BCR, COG1649
CXD77_RS08940	COG0726	polysaccharide deacetylase
CXD77_RS08960	COG1846	Transcriptional regulator
CXD77_RS08965	COG2197	response regulator
CXD77_RS08980	COG0166	Belongs to the GPI family
CXD77_RS08985	COG1045	serine acetyltransferase
CXD77_RS08995	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CXD77_RS09000	COG0483	inositol monophosphate 1-phosphatase activity
CXD77_RS09005	COG1012	belongs to the aldehyde dehydrogenase family
CXD77_RS09010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CXD77_RS09025	COG0210	DNA helicase
CXD77_RS09030	COG0598	Magnesium transport protein CorA
CXD77_RS09040	COG0747	negative chemotaxis
CXD77_RS09045	COG0601	transmembrane transport
CXD77_RS09050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD77_RS09055	COG4172	Belongs to the ABC transporter superfamily
CXD77_RS09060	COG1846	Transcriptional regulator
CXD77_RS09115	COG4964	Belongs to the GSP D family
CXD77_RS09155	COG2204	response regulator
CXD77_RS09170	COG1595	DNA-templated transcription, initiation
CXD77_RS09180	COG3474	cytochrome
CXD77_RS09185	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CXD77_RS09200	COG3384	dioxygenase
CXD77_RS09205	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CXD77_RS09235	COG2885	chlorophyll binding
CXD77_RS09270	COG0697	spore germination
CXD77_RS09275	COG0730	response to heat
CXD77_RS09290	COG0583	DNA-binding transcription factor activity
CXD77_RS09295	COG0427	acetyl-CoA hydrolase
CXD77_RS09340	COG3468	outer membrane autotransporter barrel domain protein
CXD77_RS09345	COG0424	maF-like protein
CXD77_RS09350	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CXD77_RS09355	COG0799	negative regulation of ribosome biogenesis
CXD77_RS09360	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CXD77_RS09365	COG0408	coproporphyrinogen oxidase activity
CXD77_RS09370	COG0151	Belongs to the GarS family
CXD77_RS09375	COG0217	transcriptional regulatory protein
CXD77_RS09380	COG0433	COG0433 Predicted ATPase
CXD77_RS09385	COG1115	amino acid carrier protein
CXD77_RS09390	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CXD77_RS09400	COG1012	belongs to the aldehyde dehydrogenase family
CXD77_RS09425	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CXD77_RS09440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD77_RS09450	COG0747	negative chemotaxis
CXD77_RS09460	COG0473	3-isopropylmalate dehydrogenase activity
CXD77_RS09465	COG2814	Major facilitator Superfamily
CXD77_RS09470	COG1566	PFAM secretion protein HlyD family protein
CXD77_RS09480	COG1846	Transcriptional regulator
CXD77_RS09490	COG0697	spore germination
CXD77_RS09500	COG0501	Belongs to the peptidase M48B family
CXD77_RS09520	COG0583	DNA-binding transcription factor activity
CXD77_RS09525	COG3842	ATPase activity
CXD77_RS09530	COG1178	ABC-type Fe3 transport system permease component
CXD77_RS09535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CXD77_RS09540	COG1840	ABC-type Fe3 transport system, periplasmic component
CXD77_RS09565	COG2233	PERMEase
CXD77_RS09570	COG0840	transmembrane signaling receptor activity
CXD77_RS09575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CXD77_RS09605	COG4789	Type iii secretion
CXD77_RS09670	COG4669	(LipO)protein
CXD77_RS09705	COG4790	Type iii secretion
CXD77_RS09710	COG4794	Type iii secretion
CXD77_RS09715	COG4791	protein targeting
CXD77_RS09720	COG4792	protein secretion
CXD77_RS09735	COG1595	DNA-templated transcription, initiation
CXD77_RS09760	COG2770	Histidine kinase
CXD77_RS09760	COG2208	phosphoserine phosphatase activity
CXD77_RS09770	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CXD77_RS09775	COG2172	sigma factor antagonist activity
CXD77_RS09780	COG1366	Belongs to the anti-sigma-factor antagonist family
CXD77_RS09785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXD77_RS09820	COG2358	TRAP transporter, solute receptor (TAXI family
CXD77_RS09825	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CXD77_RS09855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CXD77_RS09865	COG2252	PERMEase
CXD77_RS09870	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CXD77_RS09880	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CXD77_RS09885	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CXD77_RS09915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CXD77_RS09920	COG0789	Transcriptional regulator
CXD77_RS09930	COG0678	peroxiredoxin activity
CXD77_RS09930	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CXD77_RS09940	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CXD77_RS09945	COG0584	glycerophosphoryl diester phosphodiesterase
CXD77_RS09950	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CXD77_RS09960	COG4181	ATPase activity
CXD77_RS09980	COG2823	Periplasmic or secreted lipoprotein
CXD77_RS09990	COG3237	CsbD-like
CXD77_RS09995	COG1181	Belongs to the D-alanine--D-alanine ligase family
CXD77_RS09995	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CXD77_RS10000	COG0189	ligase activity
CXD77_RS10000	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CXD77_RS10020	COG2833	Protein of unknown function (DUF455)
CXD77_RS10025	COG2951	lytic endotransglycosylase activity
CXD77_RS10045	COG1522	sequence-specific DNA binding
CXD77_RS10055	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CXD77_RS10060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CXD77_RS10065	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CXD77_RS10070	COG0196	riboflavin kinase activity
CXD77_RS10075	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CXD77_RS10095	COG0210	DNA helicase
CXD77_RS10100	COG4771	TonB-dependent receptor
CXD77_RS10105	COG0488	(ABC) transporter
CXD77_RS10110	COG2890	protein-(glutamine-N5) methyltransferase activity
CXD77_RS10115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CXD77_RS10120	COG2171	N-acyltransferase activity
CXD77_RS10155	COG1278	Cold shock
CXD77_RS10165	COG1278	Cold shock
CXD77_RS10175	COG0544	peptidyl-prolyl cis-trans isomerase activity
CXD77_RS10180	COG0740	serine-type endopeptidase activity
CXD77_RS10185	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CXD77_RS10190	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CXD77_RS10195	COG0583	DNA-binding transcription factor activity
CXD77_RS10200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD77_RS10215	COG1024	Enoyl-CoA hydratase
CXD77_RS10225	COG0183	Belongs to the thiolase family
CXD77_RS10230	COG1028	Short-chain dehydrogenase reductase Sdr
CXD77_RS10250	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CXD77_RS10280	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CXD77_RS10290	COG0556	nucleotide-excision repair
CXD77_RS10295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CXD77_RS10305	COG1104	cysteine desulfurase activity
CXD77_RS10310	COG0822	iron-sulfur transferase activity
CXD77_RS10315	COG0316	Belongs to the HesB IscA family
CXD77_RS10320	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CXD77_RS10325	COG0443	Heat shock 70 kDa protein
CXD77_RS10330	COG0633	Ferredoxin
CXD77_RS10350	COG1024	Enoyl-CoA hydratase
CXD77_RS10365	COG3395	kinase activity
CXD77_RS10385	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CXD77_RS10395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD77_RS10425	COG0747	negative chemotaxis
CXD77_RS10430	COG0601	transmembrane transport
CXD77_RS10435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD77_RS10440	COG4172	Belongs to the ABC transporter superfamily
CXD77_RS10445	COG0154	amidase activity
CXD77_RS10490	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CXD77_RS10495	COG0425	Belongs to the sulfur carrier protein TusA family
CXD77_RS10505	COG0228	four-way junction DNA binding
CXD77_RS10510	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CXD77_RS10515	COG0336	Belongs to the RNA methyltransferase TrmD family
CXD77_RS10520	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CXD77_RS10545	COG0642	Histidine kinase
CXD77_RS10560	COG0525	valine-tRNA ligase activity
CXD77_RS10565	COG0105	UTP biosynthetic process
CXD77_RS10570	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CXD77_RS10580	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CXD77_RS10585	COG0124	histidyl-tRNA synthetase
CXD77_RS10590	COG2976	Protein conserved in bacteria
CXD77_RS10595	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CXD77_RS10600	COG1160	GTP binding
CXD77_RS10605	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CXD77_RS10610	COG1923	regulation of RNA biosynthetic process
CXD77_RS10615	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CXD77_RS10620	COG0330	HflC and HflK could
CXD77_RS10625	COG0330	HflC and HflK could
CXD77_RS10630	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CXD77_RS10635	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CXD77_RS10640	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CXD77_RS10645	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CXD77_RS10660	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CXD77_RS10695	COG0628	permease
CXD77_RS10700	COG0842	Transport permease protein
CXD77_RS10705	COG1131	(ABC) transporter
CXD77_RS10775	COG0156	8-amino-7-oxononanoate synthase activity
CXD77_RS10785	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CXD77_RS10785	COG4106	trans-aconitate 2-methyltransferase activity
CXD77_RS10790	COG1380	Effector of murein hydrolase LrgA
CXD77_RS10815	COG3284	Transcriptional regulator
CXD77_RS10820	COG1012	belongs to the aldehyde dehydrogenase family
CXD77_RS10835	COG2733	membrane
CXD77_RS10840	COG0583	DNA-binding transcription factor activity
CXD77_RS10845	COG0384	phenazine biosynthesis protein PhzF
CXD77_RS10850	COG5507	3-demethylubiquinone-9 3-methyltransferase
CXD77_RS10855	COG2169	Transcriptional regulator
CXD77_RS10885	COG0659	secondary active sulfate transmembrane transporter activity
CXD77_RS10910	COG1132	(ABC) transporter
CXD77_RS10950	COG2207	Transcriptional regulator
CXD77_RS11090	COG2346	COG2346, Truncated hemoglobins
CXD77_RS11120	COG0583	DNA-binding transcription factor activity
CXD77_RS11135	COG0183	Belongs to the thiolase family
CXD77_RS11150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD77_RS11155	COG0633	Ferredoxin
CXD77_RS11165	COG1024	Enoyl-CoA hydratase
CXD77_RS11175	COG4638	Rieske (2fe-2S)
CXD77_RS11185	COG0559	Belongs to the binding-protein-dependent transport system permease family
CXD77_RS11205	COG2224	Isocitrate lyase
CXD77_RS11210	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CXD77_RS11210	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CXD77_RS11220	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CXD77_RS11225	COG0322	excinuclease ABC activity
CXD77_RS11230	COG1472	Belongs to the glycosyl hydrolase 3 family
CXD77_RS11235	COG0736	holo-[acyl-carrier-protein] synthase activity
CXD77_RS11240	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CXD77_RS11250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CXD77_RS11255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CXD77_RS11280	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CXD77_RS11295	COG2032	superoxide dismutase activity
CXD77_RS11310	COG1024	Enoyl-CoA hydratase
CXD77_RS11320	COG1802	Transcriptional regulator
CXD77_RS11330	COG0183	Belongs to the thiolase family
CXD77_RS11335	COG1942	4-Oxalocrotonate Tautomerase
CXD77_RS11345	COG4176	ABC-type proline glycine betaine transport system permease component
CXD77_RS11365	COG2814	Major facilitator Superfamily
CXD77_RS11370	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CXD77_RS11375	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CXD77_RS11410	COG2814	Major facilitator Superfamily
CXD77_RS11415	COG0495	leucyl-tRNA aminoacylation
CXD77_RS11430	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CXD77_RS11440	COG0154	amidase activity
CXD77_RS11445	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXD77_RS11495	COG1530	ribonuclease E activity
CXD77_RS11500	COG0077	Prephenate dehydratase
CXD77_RS11515	COG1132	(ABC) transporter
CXD77_RS11520	COG0859	PFAM glycosyl transferase family 9
CXD77_RS11545	COG2194	sulfuric ester hydrolase activity
CXD77_RS11550	COG0438	transferase activity, transferring glycosyl groups
CXD77_RS11555	COG0463	Glycosyl transferase, family 2
CXD77_RS11560	COG0726	polysaccharide deacetylase
CXD77_RS11565	COG0438	transferase activity, transferring glycosyl groups
CXD77_RS11580	COG1643	Atp-dependent helicase
CXD77_RS11585	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CXD77_RS11585	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CXD77_RS11590	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CXD77_RS11600	COG0704	Plays a role in the regulation of phosphate uptake
CXD77_RS11605	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CXD77_RS11610	COG1960	acyl-CoA dehydrogenase activity
CXD77_RS11635	COG1177	transmembrane transport
CXD77_RS11640	COG1176	ABC-type spermidine putrescine transport system, permease component I
CXD77_RS11645	COG3842	ATPase activity
CXD77_RS11650	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CXD77_RS11665	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CXD77_RS11670	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CXD77_RS11680	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CXD77_RS11680	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CXD77_RS11695	COG0372	Belongs to the citrate synthase family
CXD77_RS11700	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CXD77_RS11705	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CXD77_RS11710	COG1053	succinate dehydrogenase
CXD77_RS11715	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CXD77_RS11720	COG2009	succinate dehydrogenase
CXD77_RS11725	COG2188	Transcriptional regulator
CXD77_RS11730	COG0039	L-malate dehydrogenase activity
CXD77_RS11760	COG1981	membrane
CXD77_RS11785	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CXD77_RS11795	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CXD77_RS11825	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CXD77_RS11830	COG0148	phosphopyruvate hydratase activity
CXD77_RS11840	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CXD77_RS11845	COG0504	CTP synthase activity
CXD77_RS11870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD77_RS11880	COG0747	negative chemotaxis
CXD77_RS11885	COG4172	Belongs to the ABC transporter superfamily
CXD77_RS11890	COG1446	asparaginase
CXD77_RS11920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CXD77_RS11935	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CXD77_RS11940	COG0697	spore germination
CXD77_RS11945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CXD77_RS11955	COG3193	protein, possibly involved in utilization of glycolate and propanediol
CXD77_RS11965	COG0791	NLP P60 protein
CXD77_RS11980	COG0583	DNA-binding transcription factor activity
CXD77_RS11995	COG0583	DNA-binding transcription factor activity
CXD77_RS12005	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CXD77_RS12020	COG0670	Belongs to the BI1 family
CXD77_RS12025	COG3181	Tripartite tricarboxylate transporter family receptor
CXD77_RS12040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CXD77_RS12050	COG1381	Involved in DNA repair and RecF pathway recombination
CXD77_RS12055	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CXD77_RS12060	COG0571	ribonuclease III activity
CXD77_RS12065	COG0681	Belongs to the peptidase S26 family
CXD77_RS12070	COG0481	GTPase activity
CXD77_RS12075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CXD77_RS12100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CXD77_RS12105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CXD77_RS12120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CXD77_RS12125	COG0416	fatty acid biosynthetic process
CXD77_RS12130	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CXD77_RS12135	COG1399	metal-binding, possibly nucleic acid-binding protein
CXD77_RS12140	COG0424	maF-like protein
CXD77_RS12150	COG3023	N-Acetylmuramoyl-L-alanine amidase
CXD77_RS12165	COG3022	response to hydroperoxide
CXD77_RS12180	COG0135	phosphoribosylanthranilate isomerase activity
CXD77_RS12195	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CXD77_RS12200	COG0101	tRNA pseudouridine synthase activity
CXD77_RS12210	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CXD77_RS12215	COG0473	3-isopropylmalate dehydrogenase activity
CXD77_RS12220	COG0066	3-isopropylmalate dehydratase activity
CXD77_RS12225	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CXD77_RS12235	COG1122	ATPase activity
CXD77_RS12270	COG0243	molybdopterin cofactor binding
CXD77_RS12270	COG3383	formate dehydrogenase (NAD+) activity
CXD77_RS12300	COG0489	protein tyrosine kinase activity
CXD77_RS12305	COG0746	molybdenum cofactor guanylyltransferase activity
CXD77_RS12310	COG0303	'Molybdopterin
CXD77_RS12315	COG1763	Mo-molybdopterin cofactor biosynthetic process
CXD77_RS12325	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CXD77_RS12330	COG5001	Diguanylate cyclase
CXD77_RS12350	COG3842	ATPase activity
CXD77_RS12360	COG0406	alpha-ribazole phosphatase activity
CXD77_RS12370	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CXD77_RS12375	COG0505	Belongs to the CarA family
CXD77_RS12380	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CXD77_RS12415	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CXD77_RS12420	COG1960	acyl-CoA dehydrogenase activity
CXD77_RS12430	COG2867	negative regulation of translational initiation
CXD77_RS12440	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CXD77_RS12445	COG3706	GGDEF domain
CXD77_RS12450	COG0330	HflC and HflK could
CXD77_RS12465	COG0519	Catalyzes the synthesis of GMP from XMP
CXD77_RS12465	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CXD77_RS12475	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CXD77_RS12480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CXD77_RS12485	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CXD77_RS12490	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CXD77_RS12500	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CXD77_RS12505	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CXD77_RS12510	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CXD77_RS12515	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CXD77_RS12520	COG0750	zinc metalloprotease
CXD77_RS12525	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CXD77_RS12535	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CXD77_RS12540	COG0233	cytoplasmic translational termination
CXD77_RS12545	COG0528	UMP kinase activity
CXD77_RS12550	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CXD77_RS12555	COG0052	Belongs to the universal ribosomal protein uS2 family
CXD77_RS12560	COG0024	Methionine aminopeptidase
CXD77_RS12565	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CXD77_RS12595	COG0285	dihydrofolate synthase activity
CXD77_RS12630	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CXD77_RS12640	COG1677	Flagellar hook-basal body complex protein FliE
CXD77_RS12650	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CXD77_RS12655	COG1317	bacterial-type flagellum organization
CXD77_RS12660	COG1157	protein secretion by the type III secretion system
CXD77_RS12685	COG1580	Controls the rotational direction of flagella during chemotaxis
CXD77_RS12705	COG1338	Plays a role in the flagellum-specific transport system
CXD77_RS12725	COG0840	transmembrane signaling receptor activity
CXD77_RS12730	COG0840	transmembrane signaling receptor activity
CXD77_RS12735	COG0840	transmembrane signaling receptor activity
CXD77_RS12745	COG1256	bacterial-type flagellum assembly
CXD77_RS12755	COG1706	bacterial-type flagellum-dependent cell motility
CXD77_RS12760	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CXD77_RS12775	COG1749	Flagellar hook protein flgE
CXD77_RS12785	COG1558	bacterial-type flagellum-dependent cell motility
CXD77_RS12790	COG1815	bacterial-type flagellum-dependent cell motility
CXD77_RS12830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD77_RS12835	COG0765	amino acid transport
CXD77_RS12840	COG1126	abc transporter atp-binding protein
CXD77_RS12855	COG4948	Mandelate Racemase Muconate Lactonizing
CXD77_RS12860	COG3181	Tripartite tricarboxylate transporter family receptor
CXD77_RS12870	COG0066	3-isopropylmalate dehydratase activity
CXD77_RS12885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD77_RS12895	COG3181	Tripartite tricarboxylate transporter family receptor
CXD77_RS12905	COG1802	Transcriptional regulator
CXD77_RS12920	COG0583	DNA-binding transcription factor activity
CXD77_RS12940	COG1695	Transcriptional regulator
CXD77_RS12950	COG3568	Endonuclease Exonuclease Phosphatase
CXD77_RS12955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXD77_RS13005	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CXD77_RS13015	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CXD77_RS13035	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CXD77_RS13065	COG0667	Aldo Keto reductase
CXD77_RS13080	COG2259	Doxx family
CXD77_RS13110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD77_RS13130	COG0386	Belongs to the glutathione peroxidase family
CXD77_RS13135	COG0625	glutathione transferase activity
CXD77_RS13150	COG0095	Lipoate-protein ligase
CXD77_RS13165	COG0688	phosphatidylethanolamine metabolic process
CXD77_RS13175	COG1464	Belongs to the NlpA lipoprotein family
CXD77_RS13190	COG2363	Small membrane protein
CXD77_RS13215	COG3842	ATPase activity
CXD77_RS13220	COG0395	ABC-type sugar transport system, permease component
CXD77_RS13225	COG1175	transmembrane transport
CXD77_RS13230	COG1653	transport
CXD77_RS13240	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CXD77_RS13260	COG0559	Belongs to the binding-protein-dependent transport system permease family
CXD77_RS13280	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CXD77_RS13305	COG2311	Membrane
CXD77_RS13330	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CXD77_RS13340	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CXD77_RS13345	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CXD77_RS13350	COG1760	l-serine dehydratase
CXD77_RS13355	COG1283	sodium-dependent phosphate transmembrane transporter activity
CXD77_RS13360	COG0412	Dienelactone hydrolase
CXD77_RS13375	COG1611	Belongs to the LOG family
CXD77_RS13395	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CXD77_RS13400	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CXD77_RS13405	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CXD77_RS13410	COG0195	Participates in both transcription termination and antitermination
CXD77_RS13410	COG2251	uridine kinase activity
CXD77_RS13415	COG0779	Required for maturation of 30S ribosomal subunits
CXD77_RS13420	COG1187	pseudouridine synthase activity
CXD77_RS13425	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CXD77_RS13435	COG0583	DNA-binding transcription factor activity
CXD77_RS13445	COG0523	cobalamin synthesis protein
CXD77_RS13465	COG0625	glutathione transferase activity
CXD77_RS13470	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CXD77_RS13475	COG1047	Peptidyl-prolyl cis-trans
CXD77_RS13480	COG2003	Belongs to the UPF0758 family
CXD77_RS13485	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CXD77_RS13490	COG3483	tryptophan 2,3-dioxygenase activity
CXD77_RS13495	COG0254	rRNA binding
CXD77_RS13505	COG0534	Mate efflux family protein
CXD77_RS13525	COG2304	oxidoreductase activity
CXD77_RS13545	COG1028	Short-chain dehydrogenase reductase Sdr
CXD77_RS13550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CXD77_RS13555	COG1562	ergosterol biosynthetic process
CXD77_RS13560	COG1562	ergosterol biosynthetic process
CXD77_RS13565	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CXD77_RS13565	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CXD77_RS13570	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CXD77_RS13580	COG0842	Transport permease protein
CXD77_RS13585	COG1131	(ABC) transporter
CXD77_RS13605	COG1477	protein flavinylation
CXD77_RS13620	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CXD77_RS13635	COG5564	TIM-barrel signal transduction protein
CXD77_RS13640	COG5441	Belongs to the UPF0261 family
CXD77_RS13650	COG3468	outer membrane autotransporter barrel domain protein
CXD77_RS13670	COG0542	response to heat
CXD77_RS13675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CXD77_RS13690	COG0494	nUDIX hydrolase
CXD77_RS13695	COG3530	Putative quorum-sensing-regulated virulence factor
CXD77_RS13705	COG1595	DNA-templated transcription, initiation
CXD77_RS13710	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CXD77_RS13745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD77_RS13750	COG0765	amino acid transport
CXD77_RS13755	COG0765	amino acid transport
CXD77_RS13785	COG2988	succinylglutamate desuccinylase activity
CXD77_RS13810	COG3181	Tripartite tricarboxylate transporter family receptor
CXD77_RS13815	COG2084	Dehydrogenase
CXD77_RS13830	COG1619	proteins homologs of microcin C7 resistance protein MccF
CXD77_RS13845	COG2814	Major facilitator Superfamily
CXD77_RS13855	COG0583	DNA-binding transcription factor activity
CXD77_RS13895	COG0672	)-iron permease
CXD77_RS13910	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
CXD77_RS13915	COG1028	Short-chain dehydrogenase reductase Sdr
CXD77_RS13920	COG3243	poly(R)-hydroxyalkanoic acid synthase
CXD77_RS13930	COG0564	pseudouridine synthase activity
CXD77_RS13940	COG1199	ATP-dependent helicase activity
CXD77_RS13945	COG2183	response to ionizing radiation
CXD77_RS13950	COG0180	Tryptophanyl-tRNA synthetase
CXD77_RS13975	COG3181	Tripartite tricarboxylate transporter family receptor
CXD77_RS13985	COG0583	DNA-binding transcription factor activity
CXD77_RS13990	COG1028	Short-chain dehydrogenase reductase Sdr
CXD77_RS13995	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CXD77_RS14000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CXD77_RS14005	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXD77_RS14010	COG0567	Dehydrogenase, E1 component
CXD77_RS14020	COG1522	sequence-specific DNA binding
CXD77_RS14030	COG0281	malic enzyme
CXD77_RS14030	COG0280	phosphate acetyltransferase
CXD77_RS14035	COG3539	Fimbrial protein
CXD77_RS14055	COG0613	PHP domain protein
CXD77_RS14065	COG0658	competence protein
CXD77_RS14065	COG2333	competence protein COMEC
CXD77_RS14090	COG0084	hydrolase, TatD family'
CXD77_RS14095	COG1136	(ABC) transporter
CXD77_RS14110	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CXD77_RS14120	COG1028	Short-chain dehydrogenase reductase Sdr
CXD77_RS14125	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CXD77_RS14140	COG1022	Amp-dependent synthetase and ligase
CXD77_RS14175	COG2205	protein histidine kinase activity
CXD77_RS14180	COG0745	RESPONSE REGULATOR receiver
CXD77_RS14185	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CXD77_RS14195	COG1295	ribonuclease BN
CXD77_RS14210	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CXD77_RS14240	COG1534	Rna-binding protein
CXD77_RS14245	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CXD77_RS14250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CXD77_RS14260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CXD77_RS14270	COG0248	Ppx GppA phosphatase
CXD77_RS14295	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CXD77_RS14310	COG2732	(Barnase) inhibitor
CXD77_RS14320	COG0280	phosphate acetyltransferase
CXD77_RS14320	COG0281	malic enzyme
CXD77_RS14330	COG0436	Aminotransferase
CXD77_RS14340	COG0741	lytic transglycosylase activity
CXD77_RS14345	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CXD77_RS14370	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CXD77_RS14370	COG1648	precorrin-2 dehydrogenase activity
CXD77_RS14375	COG3468	outer membrane autotransporter barrel domain protein
CXD77_RS14385	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CXD77_RS14390	COG2027	D-alanyl-D-alanine carboxypeptidase
CXD77_RS14395	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CXD77_RS14400	COG0343	queuine tRNA-ribosyltransferase activity
CXD77_RS14405	COG1862	Preprotein translocase
CXD77_RS14410	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CXD77_RS14415	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CXD77_RS14430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CXD77_RS14435	COG1702	phosphate starvation-inducible protein PhoH
CXD77_RS14440	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CXD77_RS14445	COG4535	Mg2 and Co2 transporter CorC
CXD77_RS14455	COG0667	Aldo Keto reductase
CXD77_RS14480	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CXD77_RS14485	COG0745	RESPONSE REGULATOR receiver
CXD77_RS14490	COG2201	protein-glutamate methylesterase activity
CXD77_RS14500	COG0840	transmembrane signaling receptor activity
CXD77_RS14515	COG0745	RESPONSE REGULATOR receiver
CXD77_RS14550	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CXD77_RS14560	COG0739	heme binding
CXD77_RS14570	COG0521	Mo-molybdopterin cofactor biosynthetic process
CXD77_RS14580	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CXD77_RS14610	COG0625	glutathione transferase activity
CXD77_RS14625	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CXD77_RS14630	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CXD77_RS14635	COG0126	phosphoglycerate kinase activity
CXD77_RS14640	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CXD77_RS14645	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CXD77_RS14650	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CXD77_RS14660	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CXD77_RS14665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CXD77_RS14670	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXD77_RS14675	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CXD77_RS14685	COG4566	intracellular signal transduction
CXD77_RS14690	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CXD77_RS14695	COG0339	signal peptide processing
CXD77_RS14700	COG1999	signal sequence binding
CXD77_RS14730	COG1187	pseudouridine synthase activity
CXD77_RS14735	COG3161	chorismate lyase activity
CXD77_RS14750	COG0667	Aldo Keto reductase
CXD77_RS14765	COG0335	large ribosomal subunit rRNA binding
CXD77_RS14800	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CXD77_RS14820	COG0450	alkyl hydroperoxide reductase
CXD77_RS14825	COG1960	acyl-CoA dehydrogenase activity
CXD77_RS14840	COG0123	including yeast histone deacetylase and acetoin utilization protein
CXD77_RS14845	COG2951	lytic endotransglycosylase activity
CXD77_RS14860	COG1596	polysaccharide export
CXD77_RS14860	COG1555	photosystem II stabilization
CXD77_RS14865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CXD77_RS14870	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CXD77_RS14875	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CXD77_RS14895	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CXD77_RS14900	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CXD77_RS14905	COG0287	Prephenate dehydrogenase
CXD77_RS14915	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CXD77_RS14930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CXD77_RS14940	COG2814	Major facilitator Superfamily
CXD77_RS14975	COG0583	DNA-binding transcription factor activity
CXD77_RS15015	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CXD77_RS15030	COG0667	Aldo Keto reductase
CXD77_RS15040	COG5265	(ABC) transporter
CXD77_RS15090	COG0439	Biotin carboxylase
CXD77_RS15095	COG2188	Transcriptional regulator
CXD77_RS15120	COG0511	ligase activity, forming carbon-carbon bonds
CXD77_RS15130	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CXD77_RS15150	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CXD77_RS15170	COG0500	methyltransferase
CXD77_RS15175	COG5265	(ABC) transporter
CXD77_RS15190	COG0028	Belongs to the TPP enzyme family
CXD77_RS15195	COG0440	acetolactate synthase activity
CXD77_RS15200	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CXD77_RS15205	COG1183	phosphatidylcholine synthase activity
CXD77_RS15220	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CXD77_RS15225	COG1185	polyribonucleotide nucleotidyltransferase activity
CXD77_RS15240	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CXD77_RS15260	COG0149	triose-phosphate isomerase activity
CXD77_RS15265	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CXD77_RS15275	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CXD77_RS15285	COG3799	methylaspartate ammonia-lyase activity
CXD77_RS15320	COG0583	DNA-binding transcription factor activity
CXD77_RS15325	COG0626	cystathionine gamma-synthase activity
CXD77_RS15330	COG3608	succinylglutamate desuccinylase aspartoacylase
CXD77_RS15350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD77_RS15370	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
CXD77_RS15385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CXD77_RS15390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CXD77_RS15395	COG1733	regulation of RNA biosynthetic process
CXD77_RS15410	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CXD77_RS15415	COG0583	DNA-binding transcription factor activity
CXD77_RS15420	COG1597	lipid kinase activity
CXD77_RS15430	COG0671	phosphoesterase, PA-phosphatase related
CXD77_RS15460	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CXD77_RS15465	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CXD77_RS15470	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CXD77_RS15475	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CXD77_RS15480	COG0649	NAD binding
CXD77_RS15485	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CXD77_RS15495	COG1034	ATP synthesis coupled electron transport
CXD77_RS15500	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CXD77_RS15505	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CXD77_RS15515	COG0713	ATP synthesis coupled electron transport
CXD77_RS15530	COG1007	ATP synthesis coupled electron transport
CXD77_RS15540	COG4774	siderophore transport
CXD77_RS15545	COG4774	siderophore transport
CXD77_RS15560	COG0028	Belongs to the TPP enzyme family
CXD77_RS15565	COG3181	Tripartite tricarboxylate transporter family receptor
CXD77_RS15570	COG0583	DNA-binding transcription factor activity
CXD77_RS15575	COG0560	Phosphoserine phosphatase
CXD77_RS15580	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CXD77_RS15585	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CXD77_RS15590	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CXD77_RS15605	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CXD77_RS15610	COG0308	aminopeptidase N
CXD77_RS15630	COG0028	Belongs to the TPP enzyme family
CXD77_RS15650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD77_RS15660	COG0318	PFAM AMP-dependent synthetase and ligase
CXD77_RS15670	COG1802	Transcriptional regulator
CXD77_RS15680	COG1802	Transcriptional regulator
CXD77_RS15690	COG1028	Short-chain dehydrogenase reductase Sdr
CXD77_RS15710	COG1126	abc transporter atp-binding protein
CXD77_RS15715	COG0765	amino acid transport
CXD77_RS15735	COG1538	Outer membrane efflux protein
CXD77_RS15740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CXD77_RS15745	COG2274	protein secretion by the type I secretion system
CXD77_RS15750	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CXD77_RS15760	COG2994	toxin metabolic process
CXD77_RS15780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD77_RS15785	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
CXD77_RS15795	COG0583	DNA-binding transcription factor activity
CXD77_RS15805	COG0142	geranyltranstransferase activity
CXD77_RS15815	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CXD77_RS15820	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CXD77_RS15825	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CXD77_RS15830	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CXD77_RS15875	COG3712	iron ion homeostasis
CXD77_RS15880	COG4774	siderophore transport
CXD77_RS15885	COG2353	YceI-like domain
CXD77_RS15900	COG0019	diaminopimelate decarboxylase activity
CXD77_RS15920	COG0747	negative chemotaxis
CXD77_RS15925	COG0601	transmembrane transport
CXD77_RS15930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD77_RS15940	COG0154	amidase activity
CXD77_RS15945	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CXD77_RS15970	COG2154	pterin-4-alpha-carbinolamine dehydratase
CXD77_RS15980	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CXD77_RS15990	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CXD77_RS15995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CXD77_RS16000	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CXD77_RS16005	COG1929	Belongs to the glycerate kinase type-1 family
CXD77_RS16010	COG0469	pyruvate kinase activity
CXD77_RS16015	COG0700	Nucleoside recognition
CXD77_RS16050	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CXD77_RS16055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXD77_RS16070	COG0823	Involved in the tonB-independent uptake of proteins
CXD77_RS16080	COG0848	biopolymer transport protein
CXD77_RS16085	COG0811	peptide transport
CXD77_RS16090	COG0824	Thioesterase
CXD77_RS16095	COG0442	prolyl-tRNA aminoacylation
CXD77_RS16100	COG0494	nUDIX hydrolase
CXD77_RS16115	COG2135	peptidase activity
CXD77_RS16190	COG1196	nuclear chromosome segregation
CXD77_RS16330	COG1464	Belongs to the NlpA lipoprotein family
CXD77_RS16360	COG4211	Belongs to the binding-protein-dependent transport system permease family
CXD77_RS16370	COG0154	amidase activity
CXD77_RS16375	COG0288	reversible hydration of carbon dioxide
CXD77_RS16390	COG0514	ATP-dependent DNA helicase (RecQ)
CXD77_RS16395	COG2255	four-way junction helicase activity
CXD77_RS16410	COG0632	four-way junction helicase activity
CXD77_RS16415	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CXD77_RS16435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CXD77_RS16445	COG0006	proline dipeptidase activity
CXD77_RS16470	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CXD77_RS16485	COG4783	chaperone-mediated protein folding
CXD77_RS16490	COG0429	hydrolase of the alpha beta-hydrolase fold
CXD77_RS16520	COG0513	Belongs to the DEAD box helicase family
CXD77_RS16540	COG1058	Belongs to the CinA family
CXD77_RS16540	COG1546	Belongs to the CinA family
CXD77_RS16545	COG1414	Transcriptional regulator
CXD77_RS16565	COG0167	dihydroorotate dehydrogenase activity
CXD77_RS16570	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CXD77_RS16585	COG0583	DNA-binding transcription factor activity
CXD77_RS16655	COG0601	transmembrane transport
CXD77_RS16660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD77_RS16665	COG4172	Belongs to the ABC transporter superfamily
CXD77_RS16695	COG0640	Transcriptional regulator
CXD77_RS16710	COG3135	benzoate transporter
CXD77_RS16715	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CXD77_RS16720	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CXD77_RS16725	COG0742	ribosomal rna small subunit methyltransferase
CXD77_RS16740	COG3639	organic phosphonate transmembrane transporter activity
CXD77_RS16745	COG3639	organic phosphonate transmembrane transporter activity
CXD77_RS16785	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CXD77_RS16790	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CXD77_RS16800	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CXD77_RS16805	COG1058	Belongs to the CinA family
CXD77_RS16805	COG1546	Belongs to the CinA family
CXD77_RS16810	COG0284	orotidine-5'-phosphate decarboxylase activity
CXD77_RS16815	COG1252	NADH dehydrogenase
CXD77_RS16830	COG3468	outer membrane autotransporter barrel domain protein
CXD77_RS16835	COG0459	protein refolding
CXD77_RS16840	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CXD77_RS16860	COG1053	succinate dehydrogenase
CXD77_RS16875	COG0583	DNA-binding transcription factor activity
CXD77_RS16880	COG1053	succinate dehydrogenase
CXD77_RS16900	COG3706	GGDEF domain
CXD77_RS16940	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CXD77_RS16950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXD77_RS16960	COG0069	glutamate synthase activity
CXD77_RS16965	COG2391	methyltransferase activity
CXD77_RS16970	COG0679	Auxin Efflux Carrier
CXD77_RS16995	COG0557	exoribonuclease II activity
CXD77_RS17000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CXD77_RS17010	COG3128	pkhd-type hydroxylase
CXD77_RS17015	COG0776	regulation of translation
CXD77_RS17045	COG0642	Histidine kinase
CXD77_RS17050	COG3158	transport of potassium into the cell
CXD77_RS17055	COG0137	argininosuccinate synthase activity
CXD77_RS17060	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CXD77_RS17065	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CXD77_RS17075	COG0583	DNA-binding transcription factor activity
CXD77_RS17085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CXD77_RS17105	COG2186	Transcriptional regulator
CXD77_RS17115	COG2223	nitrite transmembrane transporter activity
CXD77_RS17125	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CXD77_RS17130	COG0450	alkyl hydroperoxide reductase
CXD77_RS17150	COG1214	PFAM Peptidase M22, glycoprotease
CXD77_RS17155	COG1573	uracil-dna glycosylase
CXD77_RS17160	COG0477	Major facilitator Superfamily
CXD77_RS17165	COG1196	nuclear chromosome segregation
CXD77_RS17175	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CXD77_RS17180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CXD77_RS17195	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CXD77_RS17200	COG1122	ATPase activity
CXD77_RS17205	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CXD77_RS17210	COG1268	BioY protein
CXD77_RS17230	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CXD77_RS17265	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CXD77_RS17270	COG2878	Part of a membrane complex involved in electron transport
CXD77_RS17285	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CXD77_RS17290	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CXD77_RS17295	COG0251	oxidation-reduction process
CXD77_RS17305	COG3228	Belongs to the MtfA family
CXD77_RS17310	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CXD77_RS17320	COG0133	tryptophan synthase activity
CXD77_RS17325	COG0159	tryptophan synthase activity
CXD77_RS17330	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CXD77_RS17350	COG1530	ribonuclease E activity
CXD77_RS17360	COG0546	phosphoglycolate phosphatase activity
CXD77_RS17365	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CXD77_RS17370	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CXD77_RS17385	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD77_RS17390	COG0583	DNA-binding transcription factor activity
CXD77_RS17400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD77_RS17420	COG0251	oxidation-reduction process
CXD77_RS17425	COG1017	nitric oxide dioxygenase activity
CXD77_RS17425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CXD77_RS17430	COG2031	fatty acid transporter
CXD77_RS17435	COG1012	belongs to the aldehyde dehydrogenase family
CXD77_RS17440	COG1802	Transcriptional regulator
CXD77_RS17450	COG1278	Cold shock
CXD77_RS17455	COG0583	DNA-binding transcription factor activity
CXD77_RS17480	COG0183	Belongs to the thiolase family
CXD77_RS17490	COG1960	acyl-CoA dehydrogenase activity
CXD77_RS17495	COG0583	DNA-binding transcription factor activity
CXD77_RS17500	COG3181	Tripartite tricarboxylate transporter family receptor
CXD77_RS17505	COG1024	Enoyl-CoA hydratase
CXD77_RS17510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD77_RS17515	COG1253	flavin adenine dinucleotide binding
CXD77_RS17520	COG1285	pathogenesis
CXD77_RS17530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXD77_RS17545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CXD77_RS17555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXD77_RS17565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD77_RS17570	COG3181	Tripartite tricarboxylate transporter family receptor
CXD77_RS17575	COG1960	acyl-CoA dehydrogenase activity
CXD77_RS17595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CXD77_RS17600	COG1024	Enoyl-CoA hydratase
CXD77_RS17605	COG1960	acyl-CoA dehydrogenase activity
CXD77_RS17625	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CXD77_RS17630	COG0022	dehydrogenase e1 component
CXD77_RS17635	COG1024	Enoyl-CoA hydratase
CXD77_RS17640	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXD77_RS17660	COG0683	leucine binding
CXD77_RS17665	COG0559	Belongs to the binding-protein-dependent transport system permease family
CXD77_RS17670	COG0411	ABC transporter
CXD77_RS17680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CXD77_RS17695	COG3181	Tripartite tricarboxylate transporter family receptor
CXD77_RS17725	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CXD77_RS17730	COG0793	Belongs to the peptidase S41A family
CXD77_RS17735	COG4942	peptidase
CXD77_RS17740	COG0588	phosphoglycerate mutase activity
CXD77_RS17745	COG1054	Belongs to the UPF0176 family
CXD77_RS17750	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CXD77_RS17755	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CXD77_RS17760	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CXD77_RS17765	COG3181	Tripartite tricarboxylate transporter family receptor
CXD77_RS17780	COG2226	methyltransferase
CXD77_RS17785	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CXD77_RS17800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD77_RS17805	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CXD77_RS17830	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CXD77_RS17855	COG1335	isochorismatase
CXD77_RS17860	COG2309	aminopeptidase activity
CXD77_RS17870	COG3473	Maleate cis-trans isomerase
CXD77_RS17880	COG2068	MobA-Related Protein
CXD77_RS17905	COG2204	response regulator
CXD77_RS17910	COG5000	phosphorelay sensor kinase activity
CXD77_RS17920	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CXD77_RS17920	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CXD77_RS17930	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CXD77_RS17965	COG0583	DNA-binding transcription factor activity
CXD77_RS17985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXD77_RS17990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD77_RS18005	COG0758	DNA mediated transformation
CXD77_RS18010	COG1522	sequence-specific DNA binding
CXD77_RS18020	COG0242	peptide deformylase activity
CXD77_RS18035	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CXD77_RS18045	COG0546	phosphoglycolate phosphatase activity
CXD77_RS18065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CXD77_RS18070	COG1942	4-Oxalocrotonate Tautomerase
CXD77_RS18075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD77_RS18100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CXD77_RS18120	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CXD77_RS18125	COG1024	Enoyl-CoA hydratase
CXD77_RS18130	COG1414	Transcriptional regulator
CXD77_RS18135	COG0318	PFAM AMP-dependent synthetase and ligase
CXD77_RS18140	COG3181	Tripartite tricarboxylate transporter family receptor
CXD77_RS18185	COG3422	double-strand break repair
CXD77_RS18190	COG0330	HflC and HflK could
CXD77_RS18200	COG0251	oxidation-reduction process
CXD77_RS18250	COG3723	Recombinational DNA repair protein, rece pathway
CXD77_RS18285	COG0582	viral genome integration into host DNA
CXD77_RS18320	COG0706	membrane insertase activity
CXD77_RS18325	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CXD77_RS18330	COG0594	ribonuclease P activity
CXD77_RS18335	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CXD77_RS18340	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CXD77_RS18355	COG1414	Transcriptional regulator
CXD77_RS18360	COG0154	amidase activity
CXD77_RS18375	COG1304	FMN binding
CXD77_RS18425	COG0183	Belongs to the thiolase family
CXD77_RS18430	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CXD77_RS18445	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CXD77_RS18450	COG3181	Tripartite tricarboxylate transporter family receptor
CXD77_RS18460	COG2358	TRAP transporter, solute receptor (TAXI family
CXD77_RS18470	COG1629	transport
CXD77_RS18475	COG2922	Belongs to the Smg family
CXD77_RS18500	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CXD77_RS18505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD77_RS18510	COG1028	Short-chain dehydrogenase reductase Sdr
CXD77_RS18515	COG1012	belongs to the aldehyde dehydrogenase family
CXD77_RS18525	COG0028	Belongs to the TPP enzyme family
CXD77_RS18530	COG1522	sequence-specific DNA binding
CXD77_RS18535	COG3781	membrane
CXD77_RS18545	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CXD77_RS18565	COG4206	TonB-dependent receptor
CXD77_RS18570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CXD77_RS18575	COG2022	thiamine diphosphate biosynthetic process
CXD77_RS18580	COG0351	phosphomethylpyrimidine kinase
CXD77_RS18585	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CXD77_RS18600	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CXD77_RS18610	COG0628	permease
CXD77_RS18620	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CXD77_RS18635	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CXD77_RS18640	COG0049	tRNA binding
CXD77_RS18645	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CXD77_RS18650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CXD77_RS18655	COG0051	transcription antitermination factor activity, RNA binding
CXD77_RS18660	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CXD77_RS18665	COG0088	Forms part of the polypeptide exit tunnel
CXD77_RS18670	COG0089	rRNA binding
CXD77_RS18675	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CXD77_RS18680	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CXD77_RS18685	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CXD77_RS18690	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CXD77_RS18695	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CXD77_RS18700	COG0255	Belongs to the universal ribosomal protein uL29 family
CXD77_RS18705	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CXD77_RS18725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CXD77_RS18730	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CXD77_RS18735	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CXD77_RS18740	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CXD77_RS18745	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CXD77_RS18750	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CXD77_RS18755	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CXD77_RS18760	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CXD77_RS18765	COG1841	ribosomal large subunit assembly
CXD77_RS18770	COG0200	Binds to the 23S rRNA
CXD77_RS18775	COG0201	protein transport
CXD77_RS18780	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CXD77_RS18785	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CXD77_RS18790	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CXD77_RS18795	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CXD77_RS18800	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CXD77_RS18805	COG0202	RNA polymerase activity
CXD77_RS18810	COG0203	ribosomal protein L17
CXD77_RS18815	COG0537	adenosine 5'-monophosphoramidase activity
CXD77_RS18820	COG1324	tolerance protein
CXD77_RS18825	COG4232	protein-disulfide reductase activity
CXD77_RS18840	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CXD77_RS18850	COG1333	cytochrome c biogenesis protein
CXD77_RS18855	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CXD77_RS18870	COG1965	Belongs to the frataxin family
CXD77_RS18880	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CXD77_RS18885	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CXD77_RS18890	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CXD77_RS18905	COG2814	Major facilitator Superfamily
CXD77_RS18910	COG0629	single-stranded DNA binding
CXD77_RS18950	COG0402	S-adenosylhomocysteine deaminase activity
CXD77_RS18960	COG0438	transferase activity, transferring glycosyl groups
CXD77_RS18980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD77_RS19005	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CXD77_RS19030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXD77_RS19035	COG1956	GAF domain-containing protein
CXD77_RS19040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXD77_RS19055	COG1652	LysM domain
CXD77_RS19070	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CXD77_RS19085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CXD77_RS19115	COG3181	Tripartite tricarboxylate transporter family receptor
CXD77_RS19130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD77_RS19145	COG1024	Enoyl-CoA hydratase
CXD77_RS19160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD77_RS19165	COG1309	transcriptional regulator
CXD77_RS19170	COG2816	NAD+ diphosphatase activity
CXD77_RS19175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CXD77_RS19260	COG2814	Major facilitator Superfamily
CXD77_RS19265	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CXD77_RS19285	COG1999	signal sequence binding
CXD77_RS19290	COG0109	protoheme IX farnesyltransferase activity
CXD77_RS19330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CXD77_RS19350	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CXD77_RS19355	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CXD77_RS19365	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CXD77_RS19370	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CXD77_RS19380	COG0067	glutamate synthase
CXD77_RS19380	COG0069	glutamate synthase activity
CXD77_RS19380	COG0070	glutamate synthase
CXD77_RS19390	COG3047	cAMP biosynthetic process
CXD77_RS19400	COG1127	ABC transporter
CXD77_RS19405	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CXD77_RS19410	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CXD77_RS19415	COG2853	Lipoprotein
CXD77_RS19430	COG0842	Transport permease protein
CXD77_RS19440	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CXD77_RS19445	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CXD77_RS19450	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CXD77_RS19455	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CXD77_RS19460	COG0131	Imidazoleglycerol-phosphate dehydratase
CXD77_RS19465	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CXD77_RS19470	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CXD77_RS19475	COG0107	imidazoleglycerol-phosphate synthase activity
CXD77_RS19480	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CXD77_RS19485	COG0140	phosphoribosyl-ATP diphosphatase activity
CXD77_RS19490	COG0537	adenosine 5'-monophosphoramidase activity
CXD77_RS19495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CXD77_RS19500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CXD77_RS19515	COG3181	Tripartite tricarboxylate transporter family receptor
CXD77_RS19550	COG3702	type iv secretory pathway
CXD77_RS19555	COG3451	type IV secretory pathway VirB4
CXD77_RS19570	COG3736	Type IV secretory pathway, component VirB8
CXD77_RS19575	COG3504	Conjugal transfer protein
CXD77_RS19580	COG2948	multi-organism process
CXD77_RS19585	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
CXD77_RS19595	COG0697	spore germination
CXD77_RS19615	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CXD77_RS19620	COG0747	negative chemotaxis
CXD77_RS19625	COG0601	transmembrane transport
CXD77_RS19630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD77_RS19645	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CXD77_RS19655	COG0494	nUDIX hydrolase
CXD77_RS19700	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CXD77_RS19705	COG0237	dephospho-CoA kinase activity
CXD77_RS19710	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CXD77_RS19725	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CXD77_RS19730	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CXD77_RS19740	COG0477	Major facilitator Superfamily
CXD77_RS19745	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CXD77_RS19760	COG1126	abc transporter atp-binding protein
CXD77_RS19765	COG0765	amino acid transport
CXD77_RS19770	COG4597	amino acid ABC transporter
CXD77_RS19775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD77_RS19780	COG2884	Cell division ATP-binding protein ftsE
CXD77_RS19785	COG2177	Part of the ABC transporter FtsEX involved in
CXD77_RS19790	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CXD77_RS19800	COG1194	a g-specific adenine glycosylase
CXD77_RS19810	COG2226	methyltransferase
CXD77_RS19820	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD77_RS19825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD77_RS19840	COG1024	Enoyl-CoA hydratase
CXD77_RS19860	COG1024	Enoyl-CoA hydratase
CXD77_RS19865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD77_RS19880	COG0753	catalase activity
CXD77_RS19885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD77_RS19890	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CXD77_RS19900	COG2175	clavaminate synthase activity
CXD77_RS19905	COG1473	amidohydrolase
CXD77_RS19910	COG4608	Belongs to the ABC transporter superfamily
CXD77_RS19915	COG0444	Belongs to the ABC transporter superfamily
CXD77_RS19930	COG0747	negative chemotaxis
CXD77_RS19935	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CXD77_RS19970	COG0436	Aminotransferase
CXD77_RS19975	COG1278	Cold shock