locus-tag	class	description
CXD80_RS00005	COG0445	tRNA wobble uridine modification
CXD80_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
CXD80_RS00015	COG1192	Involved in chromosome partitioning
CXD80_RS00025	COG1475	DNA binding
CXD80_RS00050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CXD80_RS00060	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CXD80_RS00070	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CXD80_RS00075	COG0081	regulation of translation
CXD80_RS00080	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CXD80_RS00085	COG0222	ribosome binding
CXD80_RS00090	COG0085	RNA polymerase activity
CXD80_RS00095	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CXD80_RS00135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD80_RS00160	COG1024	Enoyl-CoA hydratase
CXD80_RS00180	COG0752	glycyl-tRNA synthetase alpha subunit
CXD80_RS00185	COG0751	glycine-tRNA ligase activity
CXD80_RS00190	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CXD80_RS00195	COG0204	Acyl-transferase
CXD80_RS00210	COG0242	peptide deformylase activity
CXD80_RS00250	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CXD80_RS00255	COG2813	Specifically methylates the guanine in position
CXD80_RS00255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CXD80_RS00270	COG2223	nitrite transmembrane transporter activity
CXD80_RS00280	COG1794	racemase activity, acting on amino acids and derivatives
CXD80_RS00285	COG1126	abc transporter atp-binding protein
CXD80_RS00290	COG0765	amino acid transport
CXD80_RS00295	COG0765	amino acid transport
CXD80_RS00300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD80_RS00365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CXD80_RS00395	COG0326	Molecular chaperone. Has ATPase activity
CXD80_RS00400	COG0625	glutathione transferase activity
CXD80_RS00415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CXD80_RS00420	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CXD80_RS00450	COG0438	transferase activity, transferring glycosyl groups
CXD80_RS00455	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CXD80_RS00460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CXD80_RS00490	COG0859	PFAM glycosyl transferase family 9
CXD80_RS00505	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CXD80_RS00515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CXD80_RS00520	COG1127	ABC transporter
CXD80_RS00540	COG1686	Belongs to the peptidase S11 family
CXD80_RS00550	COG2921	Belongs to the UPF0250 family
CXD80_RS00555	COG0321	lipoyl(octanoyl) transferase activity
CXD80_RS00560	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CXD80_RS00595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CXD80_RS00605	COG0018	arginyl-trna synthetase
CXD80_RS00625	COG0395	ABC-type sugar transport system, permease component
CXD80_RS00630	COG1175	transmembrane transport
CXD80_RS00635	COG1653	transport
CXD80_RS00640	COG3842	ATPase activity
CXD80_RS00645	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CXD80_RS00655	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CXD80_RS00675	COG1609	Transcriptional regulator
CXD80_RS00685	COG0154	amidase activity
CXD80_RS00690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CXD80_RS00700	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CXD80_RS00710	COG0583	DNA-binding transcription factor activity
CXD80_RS00730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CXD80_RS00745	COG1802	Transcriptional regulator
CXD80_RS00760	COG1024	Enoyl-CoA hydratase
CXD80_RS00770	COG3181	Tripartite tricarboxylate transporter family receptor
CXD80_RS00785	COG1984	allophanate hydrolase subunit 2
CXD80_RS00790	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CXD80_RS00800	COG0583	DNA-binding transcription factor activity
CXD80_RS00805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CXD80_RS00815	COG5002	protein histidine kinase activity
CXD80_RS00825	COG5002	protein histidine kinase activity
CXD80_RS00830	COG0745	RESPONSE REGULATOR receiver
CXD80_RS00835	COG2226	methyltransferase
CXD80_RS00850	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CXD80_RS00870	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CXD80_RS00880	COG0513	Belongs to the DEAD box helicase family
CXD80_RS00885	COG1280	lysine exporter protein (LysE YggA)
CXD80_RS00890	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CXD80_RS00930	COG1054	Belongs to the UPF0176 family
CXD80_RS00935	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CXD80_RS00935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CXD80_RS00945	COG0489	protein tyrosine kinase activity
CXD80_RS00960	COG0717	Belongs to the dCTP deaminase family
CXD80_RS00990	COG2081	HI0933 family
CXD80_RS01000	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CXD80_RS01010	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CXD80_RS01015	COG0509	glycine decarboxylation via glycine cleavage system
CXD80_RS01020	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CXD80_RS01020	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CXD80_RS01060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CXD80_RS01075	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CXD80_RS01085	COG1414	Transcriptional regulator
CXD80_RS01090	COG1028	Short-chain dehydrogenase reductase Sdr
CXD80_RS01095	COG2031	fatty acid transporter
CXD80_RS01100	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXD80_RS01110	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CXD80_RS01115	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CXD80_RS01125	COG4257	antibiotic catabolic process
CXD80_RS01150	COG1012	belongs to the aldehyde dehydrogenase family
CXD80_RS01155	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CXD80_RS01160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CXD80_RS01185	COG1028	Short-chain dehydrogenase reductase Sdr
CXD80_RS01195	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CXD80_RS01205	COG2188	Transcriptional regulator
CXD80_RS01210	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CXD80_RS01235	COG0617	tRNA 3'-terminal CCA addition
CXD80_RS01250	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CXD80_RS01255	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CXD80_RS01260	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CXD80_RS01265	COG0586	Pfam SNARE associated Golgi protein
CXD80_RS01270	COG0860	N-Acetylmuramoyl-L-alanine amidase
CXD80_RS01275	COG0802	atpase or kinase
CXD80_RS01280	COG0114	fumarate hydratase activity
CXD80_RS01290	COG3181	Tripartite tricarboxylate transporter family receptor
CXD80_RS01300	COG0405	Gamma-glutamyltransferase
CXD80_RS01305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD80_RS01340	COG1294	oxidase, subunit
CXD80_RS01350	COG4988	ABC transporter
CXD80_RS01355	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CXD80_RS01405	COG2969	positive regulation of protein catabolic process
CXD80_RS01410	COG0625	glutathione transferase activity
CXD80_RS01415	COG2857	Cytochrome c1
CXD80_RS01420	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CXD80_RS01425	COG0723	plastoquinol--plastocyanin reductase activity
CXD80_RS01430	COG1970	mechanosensitive ion channel activity
CXD80_RS01435	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CXD80_RS01450	COG2808	Putative FMN-binding domain
CXD80_RS01455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CXD80_RS01460	COG0747	negative chemotaxis
CXD80_RS01465	COG0657	acetylesterase activity
CXD80_RS01475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CXD80_RS01480	COG2207	Transcriptional regulator
CXD80_RS01485	COG0129	dihydroxy-acid dehydratase activity
CXD80_RS01490	COG2814	Major facilitator Superfamily
CXD80_RS01495	COG0583	DNA-binding transcription factor activity
CXD80_RS01505	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
CXD80_RS01575	COG1024	Enoyl-CoA hydratase
CXD80_RS01580	COG1960	acyl-CoA dehydrogenase activity
CXD80_RS01605	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CXD80_RS01610	COG0352	thiamine-phosphate diphosphorylase activity
CXD80_RS01625	COG1678	Uncharacterized ACR, COG1678
CXD80_RS01630	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CXD80_RS01635	COG0540	Belongs to the ATCase OTCase family
CXD80_RS01650	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CXD80_RS01660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CXD80_RS01695	COG1234	tRNA 3'-trailer cleavage
CXD80_RS01715	COG3064	Membrane
CXD80_RS01745	COG1683	Conserved Protein
CXD80_RS01750	COG1120	ATPase activity
CXD80_RS01755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXD80_RS01760	COG4558	Periplasmic binding protein
CXD80_RS01765	COG3720	iron ion transport
CXD80_RS01775	COG3712	iron ion homeostasis
CXD80_RS01780	COG1595	DNA-templated transcription, initiation
CXD80_RS01815	COG1802	Transcriptional regulator
CXD80_RS01825	COG3069	C4-dicarboxylate transmembrane transporter activity
CXD80_RS01835	COG1012	belongs to the aldehyde dehydrogenase family
CXD80_RS01870	COG2860	membrane
CXD80_RS01875	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CXD80_RS01880	COG0708	Exodeoxyribonuclease III
CXD80_RS01885	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CXD80_RS01890	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CXD80_RS01895	COG0154	amidase activity
CXD80_RS01900	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CXD80_RS01905	COG1077	Cell shape determining protein MreB Mrl
CXD80_RS01910	COG1792	Involved in formation and maintenance of cell shape
CXD80_RS01920	COG0768	penicillin binding
CXD80_RS01925	COG0772	Belongs to the SEDS family
CXD80_RS01930	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CXD80_RS01935	COG0471	metal ion transport
CXD80_RS01940	COG1309	transcriptional regulator
CXD80_RS01950	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CXD80_RS01965	COG2823	Periplasmic or secreted lipoprotein
CXD80_RS01970	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CXD80_RS01985	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CXD80_RS02005	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD80_RS02015	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD80_RS02035	COG0492	ferredoxin-NADP+ reductase activity
CXD80_RS02045	COG3181	Tripartite tricarboxylate transporter family receptor
CXD80_RS02050	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXD80_RS02050	COG1024	Enoyl-CoA hydratase
CXD80_RS02055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD80_RS02060	COG0028	Belongs to the TPP enzyme family
CXD80_RS02085	COG3181	Tripartite tricarboxylate transporter family receptor
CXD80_RS02100	COG0697	spore germination
CXD80_RS02130	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CXD80_RS02135	COG0463	Glycosyl transferase, family 2
CXD80_RS02150	COG0786	glutamate:sodium symporter activity
CXD80_RS02160	COG2031	fatty acid transporter
CXD80_RS02175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CXD80_RS02205	COG3181	Tripartite tricarboxylate transporter family receptor
CXD80_RS02215	COG0277	FAD linked oxidase domain protein
CXD80_RS02220	COG1960	acyl-CoA dehydrogenase activity
CXD80_RS02225	COG1960	acyl-CoA dehydrogenase activity
CXD80_RS02235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CXD80_RS02250	COG2072	flavoprotein involved in K transport
CXD80_RS02255	COG0604	alcohol dehydrogenase
CXD80_RS02270	COG1024	Enoyl-CoA hydratase
CXD80_RS02290	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CXD80_RS02295	COG1522	sequence-specific DNA binding
CXD80_RS02300	COG0183	Belongs to the thiolase family
CXD80_RS02310	COG1960	acyl-CoA dehydrogenase activity
CXD80_RS02350	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CXD80_RS02355	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CXD80_RS02360	COG2890	protein-(glutamine-N5) methyltransferase activity
CXD80_RS02365	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CXD80_RS02375	COG3181	Tripartite tricarboxylate transporter family receptor
CXD80_RS02410	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CXD80_RS02415	COG1660	Displays ATPase and GTPase activities
CXD80_RS02425	COG2010	Cytochrome c
CXD80_RS02425	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CXD80_RS02430	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CXD80_RS02445	COG1137	ATPase activity
CXD80_RS02460	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CXD80_RS02470	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CXD80_RS02505	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CXD80_RS02510	COG3568	Endonuclease Exonuclease Phosphatase
CXD80_RS02515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXD80_RS02545	COG0154	amidase activity
CXD80_RS02555	COG1414	Transcriptional regulator
CXD80_RS02565	COG1024	Enoyl-CoA hydratase
CXD80_RS02565	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXD80_RS02575	COG2132	Multicopper oxidase
CXD80_RS02630	COG1024	Enoyl-CoA hydratase
CXD80_RS02635	COG1024	Enoyl-CoA hydratase
CXD80_RS02640	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CXD80_RS02660	COG0601	transmembrane transport
CXD80_RS02665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD80_RS02670	COG4172	Belongs to the ABC transporter superfamily
CXD80_RS02680	COG2195	Cleaves the N-terminal amino acid of tripeptides
CXD80_RS02690	COG0210	DNA helicase
CXD80_RS02695	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CXD80_RS02700	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CXD80_RS02710	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CXD80_RS02715	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CXD80_RS02720	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CXD80_RS02725	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CXD80_RS02730	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CXD80_RS02735	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CXD80_RS02745	COG0356	it plays a direct role in the translocation of protons across the membrane
CXD80_RS02770	COG1024	Enoyl-CoA hydratase
CXD80_RS02775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CXD80_RS02780	COG3634	alkyl hydroperoxide reductase activity
CXD80_RS02790	COG0037	tRNA processing
CXD80_RS02800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CXD80_RS02805	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CXD80_RS02810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CXD80_RS02815	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CXD80_RS02820	COG2967	ApaG domain
CXD80_RS02825	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CXD80_RS02830	COG0546	phosphoglycolate phosphatase activity
CXD80_RS02840	COG0512	Glutamine amidotransferase of anthranilate synthase
CXD80_RS02845	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CXD80_RS02850	COG0134	indole-3-glycerol-phosphate synthase activity
CXD80_RS02875	COG0583	DNA-binding transcription factor activity
CXD80_RS02890	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CXD80_RS02895	COG0259	pyridoxamine-phosphate oxidase activity
CXD80_RS02905	COG2814	Major facilitator Superfamily
CXD80_RS02910	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CXD80_RS02915	COG2188	Transcriptional regulator
CXD80_RS02920	COG0318	PFAM AMP-dependent synthetase and ligase
CXD80_RS02940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CXD80_RS02950	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CXD80_RS02965	COG1215	transferase activity, transferring glycosyl groups
CXD80_RS02975	COG0601	transmembrane transport
CXD80_RS03010	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CXD80_RS03015	COG2894	cell division
CXD80_RS03020	COG0850	regulation of cytokinetic process
CXD80_RS03025	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CXD80_RS03030	COG1271	oxidase subunit
CXD80_RS03065	COG2979	Protein of unknown function (DUF533)
CXD80_RS03085	COG1388	LysM domain
CXD80_RS03085	COG0741	lytic transglycosylase activity
CXD80_RS03090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CXD80_RS03095	COG2226	methyltransferase
CXD80_RS03100	COG0328	RNA-DNA hybrid ribonuclease activity
CXD80_RS03150	COG2030	dehydratase
CXD80_RS03200	COG1960	acyl-CoA dehydrogenase activity
CXD80_RS03215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD80_RS03235	COG2718	Belongs to the UPF0229 family
CXD80_RS03240	COG2719	SpoVR family
CXD80_RS03265	COG2188	Transcriptional regulator
CXD80_RS03295	COG0829	nickel cation binding
CXD80_RS03300	COG0831	urea catabolic process
CXD80_RS03310	COG0832	Belongs to the urease beta subunit family
CXD80_RS03315	COG0804	urea catabolic process
CXD80_RS03325	COG0830	nickel cation binding
CXD80_RS03330	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CXD80_RS03350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD80_RS03355	COG0601	transmembrane transport
CXD80_RS03360	COG0747	negative chemotaxis
CXD80_RS03370	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CXD80_RS03375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXD80_RS03385	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CXD80_RS03395	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CXD80_RS03400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CXD80_RS03405	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CXD80_RS03420	COG0438	transferase activity, transferring glycosyl groups
CXD80_RS03435	COG0438	transferase activity, transferring glycosyl groups
CXD80_RS03440	COG0438	transferase activity, transferring glycosyl groups
CXD80_RS03445	COG0166	Belongs to the GPI family
CXD80_RS03460	COG0277	FAD linked oxidase domain protein
CXD80_RS03465	COG0745	RESPONSE REGULATOR receiver
CXD80_RS03470	COG0642	Histidine kinase
CXD80_RS03475	COG1368	sulfuric ester hydrolase activity
CXD80_RS03485	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CXD80_RS03510	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CXD80_RS03520	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CXD80_RS03525	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CXD80_RS03535	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CXD80_RS03540	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CXD80_RS03545	COG0193	aminoacyl-tRNA hydrolase activity
CXD80_RS03555	COG0012	GTP binding
CXD80_RS03560	COG0582	viral genome integration into host DNA
CXD80_RS03585	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CXD80_RS03650	COG0745	RESPONSE REGULATOR receiver
CXD80_RS03665	COG1309	transcriptional regulator
CXD80_RS03695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD80_RS03705	COG0405	Gamma-glutamyltransferase
CXD80_RS03780	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CXD80_RS03785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXD80_RS03795	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CXD80_RS03800	COG0513	Belongs to the DEAD box helicase family
CXD80_RS03810	COG0617	tRNA 3'-terminal CCA addition
CXD80_RS03825	COG0477	Major facilitator Superfamily
CXD80_RS03835	COG0583	DNA-binding transcription factor activity
CXD80_RS03850	COG1950	PFAM Membrane protein of
CXD80_RS03855	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CXD80_RS03870	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CXD80_RS03880	COG1560	Kdo2-lipid A biosynthetic process
CXD80_RS03885	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CXD80_RS03895	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CXD80_RS03905	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CXD80_RS03915	COG0803	Belongs to the bacterial solute-binding protein 9 family
CXD80_RS03930	COG0735	belongs to the Fur family
CXD80_RS03935	COG0523	cobalamin synthesis protein
CXD80_RS03945	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CXD80_RS03950	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CXD80_RS03965	COG2096	Adenosyltransferase
CXD80_RS03985	COG2084	Dehydrogenase
CXD80_RS04035	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CXD80_RS04040	COG0129	dihydroxy-acid dehydratase activity
CXD80_RS04045	COG4654	Cytochrome c, class I
CXD80_RS04050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CXD80_RS04100	COG1473	amidohydrolase
CXD80_RS04105	COG0418	dihydroorotase activity
CXD80_RS04110	COG0488	(ABC) transporter
CXD80_RS04120	COG2001	Belongs to the MraZ family
CXD80_RS04125	COG0275	rRNA processing
CXD80_RS04130	COG3116	cell division
CXD80_RS04140	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CXD80_RS04145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CXD80_RS04150	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CXD80_RS04160	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CXD80_RS04165	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CXD80_RS04170	COG1181	Belongs to the D-alanine--D-alanine ligase family
CXD80_RS04175	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CXD80_RS04185	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CXD80_RS04190	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CXD80_RS04200	COG0739	heme binding
CXD80_RS04205	COG0653	protein targeting
CXD80_RS04225	COG1028	Short-chain dehydrogenase reductase Sdr
CXD80_RS04230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD80_RS04235	COG1522	sequence-specific DNA binding
CXD80_RS04255	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CXD80_RS04265	COG0557	exoribonuclease II activity
CXD80_RS04270	COG3150	esterase
CXD80_RS04275	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CXD80_RS04280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CXD80_RS04285	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CXD80_RS04290	COG0511	ligase activity, forming carbon-carbon bonds
CXD80_RS04295	COG0439	Biotin carboxylase
CXD80_RS04310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CXD80_RS04335	COG1696	Membrane protein involved in D-alanine export
CXD80_RS04340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXD80_RS04375	COG1522	sequence-specific DNA binding
CXD80_RS04390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CXD80_RS04395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CXD80_RS04395	COG0045	succinate-CoA ligase (ADP-forming) activity
CXD80_RS04395	COG1042	CoA-binding domain protein
CXD80_RS04410	COG1802	Transcriptional regulator
CXD80_RS04415	COG3069	C4-dicarboxylate transmembrane transporter activity
CXD80_RS04420	COG0513	Belongs to the DEAD box helicase family
CXD80_RS04425	COG0346	lactoylglutathione lyase activity
CXD80_RS04430	COG1335	isochorismatase
CXD80_RS04435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD80_RS04440	COG1116	anion transmembrane transporter activity
CXD80_RS04455	COG3028	Belongs to the UPF0307 family
CXD80_RS04460	COG0312	modulator of DNA gyrase
CXD80_RS04465	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CXD80_RS04470	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CXD80_RS04475	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CXD80_RS04480	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CXD80_RS04490	COG0316	Belongs to the HesB IscA family
CXD80_RS04495	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CXD80_RS04510	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CXD80_RS04520	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CXD80_RS04525	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CXD80_RS04540	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CXD80_RS04540	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CXD80_RS04575	COG0583	DNA-binding transcription factor activity
CXD80_RS04580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD80_RS04615	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CXD80_RS04625	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CXD80_RS04630	COG1845	cytochrome c oxidase, subunit III
CXD80_RS04635	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CXD80_RS04640	COG0640	Transcriptional regulator
CXD80_RS04660	COG3220	belongs to the UPF0276 family
CXD80_RS04705	COG1666	GTP binding
CXD80_RS04740	COG0312	modulator of DNA gyrase
CXD80_RS04745	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CXD80_RS04750	COG3210	domain, Protein
CXD80_RS04750	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CXD80_RS04750	COG3210	domain, Protein
CXD80_RS04750	COG3064	Membrane
CXD80_RS04750	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CXD80_RS04750	COG3064	Membrane
CXD80_RS04755	COG0277	FAD linked oxidase domain protein
CXD80_RS04760	COG0277	FAD linked oxidase domain protein
CXD80_RS04765	COG0277	FAD linked oxidase domain protein
CXD80_RS04770	COG0247	lactate metabolic process
CXD80_RS04775	COG2819	hydrolase of the alpha beta superfamily
CXD80_RS04815	COG0583	DNA-binding transcription factor activity
CXD80_RS04820	COG0482	sulfurtransferase activity
CXD80_RS04825	COG0730	response to heat
CXD80_RS04830	COG0625	glutathione transferase activity
CXD80_RS04835	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CXD80_RS04840	COG3909	cytochrome
CXD80_RS04880	COG0154	amidase activity
CXD80_RS04885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD80_RS04890	COG1024	Enoyl-CoA hydratase
CXD80_RS04905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD80_RS04920	COG1028	Short-chain dehydrogenase reductase Sdr
CXD80_RS04925	COG1414	Transcriptional regulator
CXD80_RS04935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CXD80_RS04940	COG0251	oxidation-reduction process
CXD80_RS04945	COG0559	Belongs to the binding-protein-dependent transport system permease family
CXD80_RS04980	COG0583	DNA-binding transcription factor activity
CXD80_RS04990	COG0590	tRNA wobble adenosine to inosine editing
CXD80_RS04995	COG2807	transmembrane transport
CXD80_RS05015	COG0154	amidase activity
CXD80_RS05020	COG0307	riboflavin synthase, alpha
CXD80_RS05025	COG3181	Tripartite tricarboxylate transporter family receptor
CXD80_RS05030	COG1522	sequence-specific DNA binding
CXD80_RS05040	COG0318	PFAM AMP-dependent synthetase and ligase
CXD80_RS05050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD80_RS05070	COG1063	alcohol dehydrogenase
CXD80_RS05095	COG1418	mRNA catabolic process
CXD80_RS05100	COG1448	Aminotransferase
CXD80_RS05105	COG0583	DNA-binding transcription factor activity
CXD80_RS05115	COG0477	Major facilitator Superfamily
CXD80_RS05120	COG1028	Short-chain dehydrogenase reductase Sdr
CXD80_RS05135	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CXD80_RS05140	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CXD80_RS05145	COG0583	DNA-binding transcription factor activity
CXD80_RS05205	COG1028	Short-chain dehydrogenase reductase Sdr
CXD80_RS05210	COG1309	transcriptional regulator
CXD80_RS05220	COG2982	Protein involved in outer membrane biogenesis
CXD80_RS05225	COG2818	Glycosylase
CXD80_RS05245	COG1653	transport
CXD80_RS05260	COG3842	ATPase activity
CXD80_RS05265	COG0395	ABC-type sugar transport system, permease component
CXD80_RS05270	COG1175	transmembrane transport
CXD80_RS05290	COG3181	Tripartite tricarboxylate transporter family receptor
CXD80_RS05295	COG2186	Transcriptional regulator
CXD80_RS05325	COG1454	alcohol dehydrogenase
CXD80_RS05345	COG2011	ABC-type metal ion transport system permease component
CXD80_RS05350	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CXD80_RS05355	COG1501	Belongs to the glycosyl hydrolase 31 family
CXD80_RS05380	COG0318	PFAM AMP-dependent synthetase and ligase
CXD80_RS05385	COG1473	amidohydrolase
CXD80_RS05395	COG2855	membrane
CXD80_RS05405	COG2239	Acts as a magnesium transporter
CXD80_RS05425	COG3181	Tripartite tricarboxylate transporter family receptor
CXD80_RS05435	COG1722	exodeoxyribonuclease VII activity
CXD80_RS05440	COG0142	geranyltranstransferase activity
CXD80_RS05445	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CXD80_RS05450	COG1469	GTP cyclohydrolase I activity
CXD80_RS05455	COG0360	Binds together with S18 to 16S ribosomal RNA
CXD80_RS05460	COG2965	DNA replication, synthesis of RNA primer
CXD80_RS05465	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CXD80_RS05470	COG0359	binds to the 23S rRNA
CXD80_RS05480	COG0305	Participates in initiation and elongation during chromosome replication
CXD80_RS05490	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CXD80_RS05495	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CXD80_RS05500	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CXD80_RS05505	COG3737	Protein of unknown function (DUF498/DUF598)
CXD80_RS05510	COG0436	Aminotransferase
CXD80_RS05535	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CXD80_RS05570	COG0268	Binds directly to 16S ribosomal RNA
CXD80_RS05580	COG0728	peptidoglycan biosynthetic process
CXD80_RS05590	COG0563	adenylate kinase activity
CXD80_RS05595	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CXD80_RS05600	COG2835	tetraacyldisaccharide 4'-kinase activity
CXD80_RS05605	COG1663	tetraacyldisaccharide 4'-kinase activity
CXD80_RS05610	COG0848	biopolymer transport protein
CXD80_RS05615	COG0811	peptide transport
CXD80_RS05625	COG1570	exodeoxyribonuclease VII activity
CXD80_RS05630	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CXD80_RS05635	COG0038	chloride channel
CXD80_RS05640	COG0183	Belongs to the thiolase family
CXD80_RS05650	COG1278	Cold shock
CXD80_RS05655	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CXD80_RS05665	COG4953	penicillin-binding protein 1C
CXD80_RS05670	COG0542	response to heat
CXD80_RS05675	COG2995	paraquat-inducible protein a
CXD80_RS05680	COG3008	intermembrane lipid transfer
CXD80_RS05680	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CXD80_RS05690	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CXD80_RS05690	COG0506	proline dehydrogenase activity
CXD80_RS05690	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CXD80_RS05725	COG2271	Major facilitator Superfamily
CXD80_RS05730	COG1309	transcriptional regulator
CXD80_RS05765	COG0477	Major facilitator Superfamily
CXD80_RS05775	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CXD80_RS05780	COG1845	cytochrome c oxidase, subunit III
CXD80_RS05785	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CXD80_RS05795	COG1028	Short-chain dehydrogenase reductase Sdr
CXD80_RS05815	COG0789	Transcriptional regulator
CXD80_RS05840	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CXD80_RS05845	COG0697	spore germination
CXD80_RS05855	COG0678	peroxiredoxin activity
CXD80_RS05865	COG0412	Dienelactone hydrolase
CXD80_RS05875	COG0315	cyclic pyranopterin monophosphate synthase activity
CXD80_RS05890	COG0521	Mo-molybdopterin cofactor biosynthetic process
CXD80_RS05895	COG0303	'Molybdopterin
CXD80_RS05900	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CXD80_RS05920	COG0165	Argininosuccinate lyase
CXD80_RS05925	COG0668	transmembrane transport
CXD80_RS05970	COG0747	negative chemotaxis
CXD80_RS05975	COG0601	transmembrane transport
CXD80_RS05990	COG1162	GTPase activity
CXD80_RS05995	COG0501	Belongs to the peptidase M48B family
CXD80_RS06000	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CXD80_RS06010	COG3327	negative regulation of DNA-templated transcription, initiation
CXD80_RS06015	COG3396	Phenylacetate-CoA oxygenase
CXD80_RS06020	COG3460	Phenylacetate-CoA oxygenase
CXD80_RS06025	COG3396	Phenylacetate-CoA oxygenase
CXD80_RS06030	COG2151	metal-sulfur cluster biosynthetic enzyme
CXD80_RS06050	COG1012	belongs to the aldehyde dehydrogenase family
CXD80_RS06055	COG1024	Enoyl-CoA hydratase
CXD80_RS06060	COG2050	protein possibly involved in aromatic compounds catabolism
CXD80_RS06070	COG3539	Fimbrial protein
CXD80_RS06090	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CXD80_RS06095	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CXD80_RS06095	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CXD80_RS06100	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CXD80_RS06105	COG0047	phosphoribosylformylglycinamidine synthase activity
CXD80_RS06105	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CXD80_RS06110	COG3210	domain, Protein
CXD80_RS06110	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CXD80_RS06110	COG3064	Membrane
CXD80_RS06140	COG0235	Class ii aldolase
CXD80_RS06145	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CXD80_RS06150	COG0720	synthase
CXD80_RS06155	COG0602	queuosine metabolic process
CXD80_RS06180	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXD80_RS06215	COG3181	Tripartite tricarboxylate transporter family receptor
CXD80_RS06240	COG3842	ATPase activity
CXD80_RS06250	COG0395	ABC-type sugar transport system, permease component
CXD80_RS06280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD80_RS06285	COG0420	3'-5' exonuclease activity
CXD80_RS06330	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CXD80_RS06330	COG0519	Catalyzes the synthesis of GMP from XMP
CXD80_RS06345	COG3550	peptidyl-serine autophosphorylation
CXD80_RS06355	COG0477	Major facilitator Superfamily
CXD80_RS06370	COG1228	amidohydrolase
CXD80_RS06380	COG1116	anion transmembrane transporter activity
CXD80_RS06385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD80_RS06420	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CXD80_RS06440	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CXD80_RS06470	COG2814	Major facilitator Superfamily
CXD80_RS06485	COG1280	lysine exporter protein (LysE YggA)
CXD80_RS06505	COG0747	negative chemotaxis
CXD80_RS06510	COG0601	transmembrane transport
CXD80_RS06515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD80_RS06520	COG4172	Belongs to the ABC transporter superfamily
CXD80_RS06525	COG1609	Transcriptional regulator
CXD80_RS06555	COG0586	Pfam SNARE associated Golgi protein
CXD80_RS06570	COG0500	methyltransferase
CXD80_RS06585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXD80_RS06595	COG0756	dUTP diphosphatase activity
CXD80_RS06605	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CXD80_RS06610	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CXD80_RS06615	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CXD80_RS06620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CXD80_RS06620	COG0072	phenylalanine-tRNA ligase activity
CXD80_RS06625	COG0776	regulation of translation
CXD80_RS06690	COG0540	Belongs to the ATCase OTCase family
CXD80_RS06695	COG2974	May be involved in recombination
CXD80_RS06705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD80_RS06710	COG0583	DNA-binding transcription factor activity
CXD80_RS06730	COG1028	Short-chain dehydrogenase reductase Sdr
CXD80_RS06745	COG3842	ATPase activity
CXD80_RS06750	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXD80_RS06750	COG1024	Enoyl-CoA hydratase
CXD80_RS06770	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CXD80_RS06775	COG2137	regulation of response to DNA damage stimulus
CXD80_RS06785	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CXD80_RS06795	COG0045	succinate-CoA ligase (ADP-forming) activity
CXD80_RS06800	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CXD80_RS06805	COG0861	Integral membrane protein TerC family
CXD80_RS06810	COG0861	Integral membrane protein TerC family
CXD80_RS06815	COG0181	hydroxymethylbilane synthase activity
CXD80_RS06875	COG4964	Belongs to the GSP D family
CXD80_RS06900	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CXD80_RS06910	COG0583	DNA-binding transcription factor activity
CXD80_RS06920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD80_RS06925	COG4311	Sarcosine oxidase, delta subunit
CXD80_RS06930	COG0446	pyridine nucleotide-disulphide oxidoreductase
CXD80_RS06930	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CXD80_RS06965	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CXD80_RS06970	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CXD80_RS06975	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CXD80_RS06980	COG0735	belongs to the Fur family
CXD80_RS06985	COG0497	DNA recombination
CXD80_RS06990	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CXD80_RS06995	COG1420	regulation of RNA biosynthetic process
CXD80_RS07000	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CXD80_RS07010	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CXD80_RS07020	COG0443	Heat shock 70 kDa protein
CXD80_RS07025	COG0484	heat shock protein binding
CXD80_RS07030	COG0612	Peptidase, M16
CXD80_RS07050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CXD80_RS07095	COG0745	RESPONSE REGULATOR receiver
CXD80_RS07105	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CXD80_RS07110	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CXD80_RS07115	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CXD80_RS07130	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CXD80_RS07150	COG1193	negative regulation of DNA recombination
CXD80_RS07155	COG0492	ferredoxin-NADP+ reductase activity
CXD80_RS07160	COG1674	ftsk spoiiie
CXD80_RS07165	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CXD80_RS07170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CXD80_RS07175	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CXD80_RS07200	COG3706	GGDEF domain
CXD80_RS07220	COG2814	Major facilitator Superfamily
CXD80_RS07250	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CXD80_RS07265	COG1028	Short-chain dehydrogenase reductase Sdr
CXD80_RS07275	COG3022	response to hydroperoxide
CXD80_RS07315	COG2197	response regulator
CXD80_RS07320	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CXD80_RS07325	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CXD80_RS07330	COG0189	ligase activity
CXD80_RS07340	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CXD80_RS07345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CXD80_RS07360	COG2423	ornithine cyclodeaminase activity
CXD80_RS07370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD80_RS07375	COG0765	amino acid transport
CXD80_RS07380	COG0765	amino acid transport
CXD80_RS07385	COG1126	abc transporter atp-binding protein
CXD80_RS07440	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CXD80_RS07450	COG2944	sequence-specific DNA binding
CXD80_RS07460	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CXD80_RS07465	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CXD80_RS07470	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CXD80_RS07475	COG0009	L-threonylcarbamoyladenylate synthase
CXD80_RS07480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD80_RS07485	COG1414	Transcriptional regulator
CXD80_RS07500	COG0765	amino acid transport
CXD80_RS07505	COG1126	abc transporter atp-binding protein
CXD80_RS07510	COG0028	Belongs to the TPP enzyme family
CXD80_RS07525	COG0028	Belongs to the TPP enzyme family
CXD80_RS07530	COG0583	DNA-binding transcription factor activity
CXD80_RS07535	COG4974	Belongs to the 'phage' integrase family
CXD80_RS07540	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CXD80_RS07545	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CXD80_RS07560	COG1686	Belongs to the peptidase S11 family
CXD80_RS07570	COG2814	Major facilitator Superfamily
CXD80_RS07580	COG1074	ATP-dependent DNA helicase activity
CXD80_RS07590	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CXD80_RS07595	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CXD80_RS07600	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CXD80_RS07620	COG2321	neutral zinc metallopeptidase
CXD80_RS07625	COG0009	L-threonylcarbamoyladenylate synthase
CXD80_RS07670	COG3360	Dodecin
CXD80_RS07675	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CXD80_RS07680	COG2850	peptidyl-arginine hydroxylation
CXD80_RS07685	COG3539	Fimbrial protein
CXD80_RS07690	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CXD80_RS07695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXD80_RS07710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD80_RS07715	COG0765	amino acid transport
CXD80_RS07720	COG1126	abc transporter atp-binding protein
CXD80_RS07725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CXD80_RS07730	COG1758	RNA polymerase activity
CXD80_RS07735	COG0194	GDP metabolic process
CXD80_RS07740	COG3258	Cytochrome c
CXD80_RS07745	COG2863	cytochrome
CXD80_RS07750	COG1028	Short-chain dehydrogenase reductase Sdr
CXD80_RS07755	COG0791	NLP P60 protein
CXD80_RS07760	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CXD80_RS07780	COG1561	YicC-like family, N-terminal region
CXD80_RS07785	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CXD80_RS07805	COG2199	diguanylate cyclase activity
CXD80_RS07805	COG2200	EAL domain
CXD80_RS07810	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CXD80_RS07820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CXD80_RS07825	COG0174	glutamine synthetase
CXD80_RS07835	COG2204	response regulator
CXD80_RS07840	COG0583	DNA-binding transcription factor activity
CXD80_RS07845	COG1741	Belongs to the pirin family
CXD80_RS07850	COG1741	Belongs to the pirin family
CXD80_RS07860	COG3842	ATPase activity
CXD80_RS07865	COG1178	ABC-type Fe3 transport system permease component
CXD80_RS07870	COG1840	ABC-type Fe3 transport system, periplasmic component
CXD80_RS07880	COG0583	DNA-binding transcription factor activity
CXD80_RS07890	COG0656	L-ascorbic acid biosynthetic process
CXD80_RS07905	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CXD80_RS07910	COG0583	DNA-binding transcription factor activity
CXD80_RS07925	COG0783	Belongs to the Dps family
CXD80_RS07945	COG0463	Glycosyl transferase, family 2
CXD80_RS07965	COG0438	transferase activity, transferring glycosyl groups
CXD80_RS07980	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CXD80_RS08005	COG0300	oxidoreductase activity
CXD80_RS08050	COG0861	Integral membrane protein TerC family
CXD80_RS08055	COG1028	Short-chain dehydrogenase reductase Sdr
CXD80_RS08075	COG0714	Associated with various cellular activities
CXD80_RS08110	COG3119	arylsulfatase activity
CXD80_RS08135	COG2197	response regulator
CXD80_RS08145	COG2944	sequence-specific DNA binding
CXD80_RS08155	COG0625	glutathione transferase activity
CXD80_RS08185	COG0179	Fumarylacetoacetate (FAA) hydrolase
CXD80_RS08190	COG1028	Short-chain dehydrogenase reductase Sdr
CXD80_RS08235	COG0431	NADPH-dependent FMN reductase
CXD80_RS08265	COG1028	Short-chain dehydrogenase reductase Sdr
CXD80_RS08270	COG0583	DNA-binding transcription factor activity
CXD80_RS08290	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CXD80_RS08290	COG2111	Na H antiporter
CXD80_RS08295	COG1006	Multisubunit Na H antiporter MnhC subunit
CXD80_RS08300	COG0651	ATP synthesis coupled electron transport
CXD80_RS08305	COG1863	multisubunit Na H antiporter MnhE subunit
CXD80_RS08310	COG2212	antiporter activity
CXD80_RS08335	COG0590	tRNA wobble adenosine to inosine editing
CXD80_RS08340	COG1619	proteins homologs of microcin C7 resistance protein MccF
CXD80_RS08345	COG1024	Enoyl-CoA hydratase
CXD80_RS08360	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CXD80_RS08365	COG0488	(ABC) transporter
CXD80_RS08400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CXD80_RS08400	COG1017	nitric oxide dioxygenase activity
CXD80_RS08405	COG1959	2 iron, 2 sulfur cluster binding
CXD80_RS08410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD80_RS08430	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CXD80_RS08435	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CXD80_RS08440	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CXD80_RS08445	COG0084	hydrolase, TatD family'
CXD80_RS08460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD80_RS08470	COG1126	abc transporter atp-binding protein
CXD80_RS08480	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CXD80_RS08495	COG0028	Belongs to the TPP enzyme family
CXD80_RS08505	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CXD80_RS08505	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CXD80_RS08515	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CXD80_RS08565	COG4336	lyase activity
CXD80_RS08575	COG2205	protein histidine kinase activity
CXD80_RS08575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD80_RS08580	COG2197	response regulator
CXD80_RS08585	COG3210	domain, Protein
CXD80_RS08585	COG3064	Membrane
CXD80_RS08585	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CXD80_RS08595	COG3121	Chaperone
CXD80_RS08600	COG3188	usher protein
CXD80_RS08605	COG3539	Fimbrial protein
CXD80_RS08610	COG2831	hemolysin activation secretion protein
CXD80_RS08625	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CXD80_RS08675	COG0668	transmembrane transport
CXD80_RS08695	COG0483	inositol monophosphate 1-phosphatase activity
CXD80_RS08700	COG1253	flavin adenine dinucleotide binding
CXD80_RS08705	COG1968	undecaprenyl-diphosphatase activity
CXD80_RS08710	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CXD80_RS08725	COG0215	cysteine-tRNA ligase activity
CXD80_RS08735	COG0825	malonyl-CoA metabolic process
CXD80_RS08745	COG0037	tRNA processing
CXD80_RS08750	COG0527	aspartate kinase activity
CXD80_RS08775	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXD80_RS08780	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CXD80_RS08780	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CXD80_RS08795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CXD80_RS08800	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CXD80_RS08805	COG1028	Short-chain dehydrogenase reductase Sdr
CXD80_RS08815	COG0583	DNA-binding transcription factor activity
CXD80_RS08840	COG3842	ATPase activity
CXD80_RS08850	COG0446	pyridine nucleotide-disulphide oxidoreductase
CXD80_RS08850	COG1902	pentaerythritol trinitrate reductase activity
CXD80_RS08855	COG1414	Transcriptional regulator
CXD80_RS08860	COG1832	CoA-binding protein
CXD80_RS08870	COG0251	oxidation-reduction process
CXD80_RS08895	COG1902	pentaerythritol trinitrate reductase activity
CXD80_RS08905	COG1215	transferase activity, transferring glycosyl groups
CXD80_RS08910	COG0726	polysaccharide deacetylase
CXD80_RS08910	COG1649	PFAM Uncharacterised BCR, COG1649
CXD80_RS08930	COG1846	Transcriptional regulator
CXD80_RS08935	COG2197	response regulator
CXD80_RS08950	COG0166	Belongs to the GPI family
CXD80_RS08955	COG1045	serine acetyltransferase
CXD80_RS08965	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CXD80_RS08970	COG0483	inositol monophosphate 1-phosphatase activity
CXD80_RS08975	COG1012	belongs to the aldehyde dehydrogenase family
CXD80_RS08980	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CXD80_RS08995	COG0210	DNA helicase
CXD80_RS09000	COG0598	Magnesium transport protein CorA
CXD80_RS09010	COG0747	negative chemotaxis
CXD80_RS09015	COG0601	transmembrane transport
CXD80_RS09020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD80_RS09025	COG4172	Belongs to the ABC transporter superfamily
CXD80_RS09030	COG1846	Transcriptional regulator
CXD80_RS09085	COG4964	Belongs to the GSP D family
CXD80_RS09125	COG2204	response regulator
CXD80_RS09140	COG1595	DNA-templated transcription, initiation
CXD80_RS09150	COG3474	cytochrome
CXD80_RS09155	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CXD80_RS09170	COG3384	dioxygenase
CXD80_RS09175	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CXD80_RS09205	COG2885	chlorophyll binding
CXD80_RS09240	COG0697	spore germination
CXD80_RS09245	COG0730	response to heat
CXD80_RS09265	COG0583	DNA-binding transcription factor activity
CXD80_RS09270	COG0427	acetyl-CoA hydrolase
CXD80_RS09325	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXD80_RS09330	COG0154	amidase activity
CXD80_RS09340	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CXD80_RS09355	COG0495	leucyl-tRNA aminoacylation
CXD80_RS09360	COG2814	Major facilitator Superfamily
CXD80_RS09395	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CXD80_RS09400	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CXD80_RS09405	COG2814	Major facilitator Superfamily
CXD80_RS09425	COG4176	ABC-type proline glycine betaine transport system permease component
CXD80_RS09435	COG1942	4-Oxalocrotonate Tautomerase
CXD80_RS09440	COG0183	Belongs to the thiolase family
CXD80_RS09450	COG1802	Transcriptional regulator
CXD80_RS09460	COG1024	Enoyl-CoA hydratase
CXD80_RS09475	COG2032	superoxide dismutase activity
CXD80_RS09490	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CXD80_RS09515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CXD80_RS09520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CXD80_RS09530	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CXD80_RS09535	COG0736	holo-[acyl-carrier-protein] synthase activity
CXD80_RS09540	COG1472	Belongs to the glycosyl hydrolase 3 family
CXD80_RS09545	COG0322	excinuclease ABC activity
CXD80_RS09550	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CXD80_RS09560	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CXD80_RS09560	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CXD80_RS09565	COG2224	Isocitrate lyase
CXD80_RS09590	COG0559	Belongs to the binding-protein-dependent transport system permease family
CXD80_RS09600	COG4638	Rieske (2fe-2S)
CXD80_RS09610	COG1024	Enoyl-CoA hydratase
CXD80_RS09620	COG0633	Ferredoxin
CXD80_RS09625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD80_RS09640	COG0183	Belongs to the thiolase family
CXD80_RS09655	COG0583	DNA-binding transcription factor activity
CXD80_RS09685	COG2346	COG2346, Truncated hemoglobins
CXD80_RS09815	COG2207	Transcriptional regulator
CXD80_RS09865	COG1132	(ABC) transporter
CXD80_RS09890	COG0659	secondary active sulfate transmembrane transporter activity
CXD80_RS09920	COG2169	Transcriptional regulator
CXD80_RS09925	COG5507	3-demethylubiquinone-9 3-methyltransferase
CXD80_RS09930	COG0384	phenazine biosynthesis protein PhzF
CXD80_RS09935	COG0583	DNA-binding transcription factor activity
CXD80_RS09940	COG2733	membrane
CXD80_RS09955	COG1012	belongs to the aldehyde dehydrogenase family
CXD80_RS09960	COG3284	Transcriptional regulator
CXD80_RS09985	COG1380	Effector of murein hydrolase LrgA
CXD80_RS09990	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CXD80_RS09990	COG4106	trans-aconitate 2-methyltransferase activity
CXD80_RS10000	COG0156	8-amino-7-oxononanoate synthase activity
CXD80_RS10070	COG1131	(ABC) transporter
CXD80_RS10075	COG0842	Transport permease protein
CXD80_RS10080	COG0628	permease
CXD80_RS10115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CXD80_RS10125	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CXD80_RS10130	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CXD80_RS10135	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CXD80_RS10140	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CXD80_RS10145	COG0330	HflC and HflK could
CXD80_RS10150	COG0330	HflC and HflK could
CXD80_RS10155	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CXD80_RS10160	COG1923	regulation of RNA biosynthetic process
CXD80_RS10165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CXD80_RS10170	COG1160	GTP binding
CXD80_RS10175	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CXD80_RS10180	COG2976	Protein conserved in bacteria
CXD80_RS10185	COG0124	histidyl-tRNA synthetase
CXD80_RS10190	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CXD80_RS10200	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CXD80_RS10205	COG0105	UTP biosynthetic process
CXD80_RS10210	COG0525	valine-tRNA ligase activity
CXD80_RS10225	COG0642	Histidine kinase
CXD80_RS10250	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CXD80_RS10255	COG0336	Belongs to the RNA methyltransferase TrmD family
CXD80_RS10260	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CXD80_RS10265	COG0228	four-way junction DNA binding
CXD80_RS10275	COG0425	Belongs to the sulfur carrier protein TusA family
CXD80_RS10280	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CXD80_RS10325	COG0154	amidase activity
CXD80_RS10330	COG4172	Belongs to the ABC transporter superfamily
CXD80_RS10335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD80_RS10340	COG0601	transmembrane transport
CXD80_RS10345	COG0747	negative chemotaxis
CXD80_RS10375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD80_RS10385	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CXD80_RS10405	COG3395	kinase activity
CXD80_RS10420	COG1024	Enoyl-CoA hydratase
CXD80_RS10440	COG0633	Ferredoxin
CXD80_RS10445	COG0443	Heat shock 70 kDa protein
CXD80_RS10450	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CXD80_RS10455	COG0316	Belongs to the HesB IscA family
CXD80_RS10460	COG0822	iron-sulfur transferase activity
CXD80_RS10465	COG1104	cysteine desulfurase activity
CXD80_RS10475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CXD80_RS10480	COG0556	nucleotide-excision repair
CXD80_RS10490	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CXD80_RS10520	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CXD80_RS10540	COG1028	Short-chain dehydrogenase reductase Sdr
CXD80_RS10545	COG0183	Belongs to the thiolase family
CXD80_RS10555	COG1024	Enoyl-CoA hydratase
CXD80_RS10570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD80_RS10575	COG0583	DNA-binding transcription factor activity
CXD80_RS10580	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CXD80_RS10585	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CXD80_RS10590	COG0740	serine-type endopeptidase activity
CXD80_RS10595	COG0544	peptidyl-prolyl cis-trans isomerase activity
CXD80_RS10605	COG1278	Cold shock
CXD80_RS10615	COG1278	Cold shock
CXD80_RS10650	COG2171	N-acyltransferase activity
CXD80_RS10655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CXD80_RS10660	COG2890	protein-(glutamine-N5) methyltransferase activity
CXD80_RS10665	COG0488	(ABC) transporter
CXD80_RS10670	COG4771	TonB-dependent receptor
CXD80_RS10675	COG0210	DNA helicase
CXD80_RS10695	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CXD80_RS10700	COG0196	riboflavin kinase activity
CXD80_RS10705	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CXD80_RS10710	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CXD80_RS10715	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CXD80_RS10725	COG1522	sequence-specific DNA binding
CXD80_RS10745	COG2951	lytic endotransglycosylase activity
CXD80_RS10750	COG2833	Protein of unknown function (DUF455)
CXD80_RS10770	COG0189	ligase activity
CXD80_RS10770	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CXD80_RS10775	COG1181	Belongs to the D-alanine--D-alanine ligase family
CXD80_RS10775	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CXD80_RS10780	COG3237	CsbD-like
CXD80_RS10790	COG2823	Periplasmic or secreted lipoprotein
CXD80_RS10815	COG4181	ATPase activity
CXD80_RS10825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CXD80_RS10830	COG0584	glycerophosphoryl diester phosphodiesterase
CXD80_RS10835	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CXD80_RS10845	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CXD80_RS10845	COG0678	peroxiredoxin activity
CXD80_RS10855	COG0789	Transcriptional regulator
CXD80_RS10860	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CXD80_RS10890	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CXD80_RS10895	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CXD80_RS10905	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CXD80_RS10910	COG2252	PERMEase
CXD80_RS10920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CXD80_RS10950	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CXD80_RS10955	COG2358	TRAP transporter, solute receptor (TAXI family
CXD80_RS10990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXD80_RS10995	COG1366	Belongs to the anti-sigma-factor antagonist family
CXD80_RS11000	COG2172	sigma factor antagonist activity
CXD80_RS11005	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CXD80_RS11015	COG2208	phosphoserine phosphatase activity
CXD80_RS11015	COG2770	Histidine kinase
CXD80_RS11040	COG1595	DNA-templated transcription, initiation
CXD80_RS11055	COG4792	protein secretion
CXD80_RS11060	COG4791	protein targeting
CXD80_RS11065	COG4794	Type iii secretion
CXD80_RS11070	COG4790	Type iii secretion
CXD80_RS11105	COG4669	(LipO)protein
CXD80_RS11170	COG4789	Type iii secretion
CXD80_RS11200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CXD80_RS11205	COG0840	transmembrane signaling receptor activity
CXD80_RS11210	COG2233	PERMEase
CXD80_RS11235	COG1840	ABC-type Fe3 transport system, periplasmic component
CXD80_RS11240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CXD80_RS11245	COG1178	ABC-type Fe3 transport system permease component
CXD80_RS11250	COG3842	ATPase activity
CXD80_RS11255	COG0583	DNA-binding transcription factor activity
CXD80_RS11275	COG0501	Belongs to the peptidase M48B family
CXD80_RS11285	COG0697	spore germination
CXD80_RS11295	COG1846	Transcriptional regulator
CXD80_RS11305	COG1566	PFAM secretion protein HlyD family protein
CXD80_RS11310	COG2814	Major facilitator Superfamily
CXD80_RS11315	COG0473	3-isopropylmalate dehydrogenase activity
CXD80_RS11325	COG0747	negative chemotaxis
CXD80_RS11335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD80_RS11350	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CXD80_RS11375	COG1012	belongs to the aldehyde dehydrogenase family
CXD80_RS11385	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CXD80_RS11390	COG1115	amino acid carrier protein
CXD80_RS11395	COG0433	COG0433 Predicted ATPase
CXD80_RS11400	COG0217	transcriptional regulatory protein
CXD80_RS11405	COG0151	Belongs to the GarS family
CXD80_RS11410	COG0408	coproporphyrinogen oxidase activity
CXD80_RS11415	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CXD80_RS11420	COG0799	negative regulation of ribosome biogenesis
CXD80_RS11425	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CXD80_RS11430	COG0424	maF-like protein
CXD80_RS11435	COG3468	outer membrane autotransporter barrel domain protein
CXD80_RS11475	COG1530	ribonuclease E activity
CXD80_RS11480	COG0077	Prephenate dehydratase
CXD80_RS11495	COG1132	(ABC) transporter
CXD80_RS11500	COG0859	PFAM glycosyl transferase family 9
CXD80_RS11525	COG2194	sulfuric ester hydrolase activity
CXD80_RS11530	COG0438	transferase activity, transferring glycosyl groups
CXD80_RS11535	COG0463	Glycosyl transferase, family 2
CXD80_RS11540	COG0726	polysaccharide deacetylase
CXD80_RS11545	COG0438	transferase activity, transferring glycosyl groups
CXD80_RS11560	COG1643	Atp-dependent helicase
CXD80_RS11565	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CXD80_RS11565	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CXD80_RS11570	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CXD80_RS11580	COG0704	Plays a role in the regulation of phosphate uptake
CXD80_RS11585	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CXD80_RS11590	COG1960	acyl-CoA dehydrogenase activity
CXD80_RS11615	COG1177	transmembrane transport
CXD80_RS11620	COG1176	ABC-type spermidine putrescine transport system, permease component I
CXD80_RS11625	COG3842	ATPase activity
CXD80_RS11630	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CXD80_RS11645	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CXD80_RS11650	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CXD80_RS11660	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CXD80_RS11660	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CXD80_RS11675	COG0372	Belongs to the citrate synthase family
CXD80_RS11680	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CXD80_RS11685	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CXD80_RS11690	COG1053	succinate dehydrogenase
CXD80_RS11695	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CXD80_RS11700	COG2009	succinate dehydrogenase
CXD80_RS11705	COG2188	Transcriptional regulator
CXD80_RS11710	COG0039	L-malate dehydrogenase activity
CXD80_RS11740	COG1981	membrane
CXD80_RS11765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CXD80_RS11775	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CXD80_RS11805	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CXD80_RS11810	COG0148	phosphopyruvate hydratase activity
CXD80_RS11820	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CXD80_RS11825	COG0504	CTP synthase activity
CXD80_RS11850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD80_RS11860	COG0747	negative chemotaxis
CXD80_RS11865	COG4172	Belongs to the ABC transporter superfamily
CXD80_RS11870	COG1446	asparaginase
CXD80_RS11900	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CXD80_RS11915	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CXD80_RS11920	COG0697	spore germination
CXD80_RS11925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CXD80_RS11935	COG3193	protein, possibly involved in utilization of glycolate and propanediol
CXD80_RS11945	COG0791	NLP P60 protein
CXD80_RS11960	COG0583	DNA-binding transcription factor activity
CXD80_RS11975	COG0583	DNA-binding transcription factor activity
CXD80_RS11985	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CXD80_RS12000	COG0670	Belongs to the BI1 family
CXD80_RS12005	COG3181	Tripartite tricarboxylate transporter family receptor
CXD80_RS12020	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CXD80_RS12030	COG1381	Involved in DNA repair and RecF pathway recombination
CXD80_RS12035	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CXD80_RS12040	COG0571	ribonuclease III activity
CXD80_RS12045	COG0681	Belongs to the peptidase S26 family
CXD80_RS12050	COG0481	GTPase activity
CXD80_RS12055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CXD80_RS12080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CXD80_RS12085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CXD80_RS12100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CXD80_RS12105	COG0416	fatty acid biosynthetic process
CXD80_RS12110	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CXD80_RS12115	COG1399	metal-binding, possibly nucleic acid-binding protein
CXD80_RS12120	COG0424	maF-like protein
CXD80_RS12130	COG3023	N-Acetylmuramoyl-L-alanine amidase
CXD80_RS12145	COG3022	response to hydroperoxide
CXD80_RS12160	COG0135	phosphoribosylanthranilate isomerase activity
CXD80_RS12175	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CXD80_RS12180	COG0101	tRNA pseudouridine synthase activity
CXD80_RS12190	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CXD80_RS12195	COG0473	3-isopropylmalate dehydrogenase activity
CXD80_RS12200	COG0066	3-isopropylmalate dehydratase activity
CXD80_RS12205	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CXD80_RS12215	COG1122	ATPase activity
CXD80_RS12250	COG0243	molybdopterin cofactor binding
CXD80_RS12250	COG3383	formate dehydrogenase (NAD+) activity
CXD80_RS12280	COG0489	protein tyrosine kinase activity
CXD80_RS12285	COG0746	molybdenum cofactor guanylyltransferase activity
CXD80_RS12290	COG0303	'Molybdopterin
CXD80_RS12295	COG1763	Mo-molybdopterin cofactor biosynthetic process
CXD80_RS12305	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CXD80_RS12310	COG5001	Diguanylate cyclase
CXD80_RS12330	COG3842	ATPase activity
CXD80_RS12340	COG0406	alpha-ribazole phosphatase activity
CXD80_RS12350	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CXD80_RS12355	COG0505	Belongs to the CarA family
CXD80_RS12360	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CXD80_RS12395	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CXD80_RS12400	COG1960	acyl-CoA dehydrogenase activity
CXD80_RS12410	COG2867	negative regulation of translational initiation
CXD80_RS12420	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CXD80_RS12425	COG3706	GGDEF domain
CXD80_RS12430	COG0330	HflC and HflK could
CXD80_RS12445	COG0519	Catalyzes the synthesis of GMP from XMP
CXD80_RS12445	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CXD80_RS12455	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CXD80_RS12460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CXD80_RS12465	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CXD80_RS12470	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CXD80_RS12480	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CXD80_RS12485	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CXD80_RS12490	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CXD80_RS12495	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CXD80_RS12500	COG0750	zinc metalloprotease
CXD80_RS12505	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CXD80_RS12515	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CXD80_RS12520	COG0233	cytoplasmic translational termination
CXD80_RS12525	COG0528	UMP kinase activity
CXD80_RS12530	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CXD80_RS12535	COG0052	Belongs to the universal ribosomal protein uS2 family
CXD80_RS12540	COG0024	Methionine aminopeptidase
CXD80_RS12545	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CXD80_RS12575	COG0285	dihydrofolate synthase activity
CXD80_RS12610	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CXD80_RS12620	COG1677	Flagellar hook-basal body complex protein FliE
CXD80_RS12630	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CXD80_RS12640	COG1157	protein secretion by the type III secretion system
CXD80_RS12665	COG1580	Controls the rotational direction of flagella during chemotaxis
CXD80_RS12685	COG1338	Plays a role in the flagellum-specific transport system
CXD80_RS12705	COG0840	transmembrane signaling receptor activity
CXD80_RS12710	COG0840	transmembrane signaling receptor activity
CXD80_RS12715	COG0840	transmembrane signaling receptor activity
CXD80_RS12725	COG1256	bacterial-type flagellum assembly
CXD80_RS12735	COG1706	bacterial-type flagellum-dependent cell motility
CXD80_RS12740	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CXD80_RS12755	COG1749	Flagellar hook protein flgE
CXD80_RS12765	COG1558	bacterial-type flagellum-dependent cell motility
CXD80_RS12770	COG1815	bacterial-type flagellum-dependent cell motility
CXD80_RS12810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD80_RS12815	COG0765	amino acid transport
CXD80_RS12820	COG1126	abc transporter atp-binding protein
CXD80_RS12835	COG4948	Mandelate Racemase Muconate Lactonizing
CXD80_RS12840	COG3181	Tripartite tricarboxylate transporter family receptor
CXD80_RS12850	COG0066	3-isopropylmalate dehydratase activity
CXD80_RS12865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD80_RS12875	COG3181	Tripartite tricarboxylate transporter family receptor
CXD80_RS12885	COG1802	Transcriptional regulator
CXD80_RS12900	COG0583	DNA-binding transcription factor activity
CXD80_RS12920	COG1695	Transcriptional regulator
CXD80_RS12930	COG3568	Endonuclease Exonuclease Phosphatase
CXD80_RS12935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXD80_RS12985	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CXD80_RS12995	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CXD80_RS13015	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CXD80_RS13045	COG0667	Aldo Keto reductase
CXD80_RS13060	COG2259	Doxx family
CXD80_RS13090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD80_RS13110	COG0386	Belongs to the glutathione peroxidase family
CXD80_RS13115	COG0625	glutathione transferase activity
CXD80_RS13130	COG0095	Lipoate-protein ligase
CXD80_RS13145	COG0688	phosphatidylethanolamine metabolic process
CXD80_RS13155	COG1464	Belongs to the NlpA lipoprotein family
CXD80_RS13170	COG2363	Small membrane protein
CXD80_RS13195	COG3842	ATPase activity
CXD80_RS13200	COG0395	ABC-type sugar transport system, permease component
CXD80_RS13205	COG1175	transmembrane transport
CXD80_RS13210	COG1653	transport
CXD80_RS13220	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CXD80_RS13240	COG0559	Belongs to the binding-protein-dependent transport system permease family
CXD80_RS13260	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CXD80_RS13285	COG2311	Membrane
CXD80_RS13310	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CXD80_RS13320	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CXD80_RS13325	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CXD80_RS13330	COG1760	l-serine dehydratase
CXD80_RS13335	COG1283	sodium-dependent phosphate transmembrane transporter activity
CXD80_RS13340	COG0412	Dienelactone hydrolase
CXD80_RS13355	COG1611	Belongs to the LOG family
CXD80_RS13375	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CXD80_RS13380	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CXD80_RS13385	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CXD80_RS13390	COG2251	uridine kinase activity
CXD80_RS13390	COG0195	Participates in both transcription termination and antitermination
CXD80_RS13395	COG0779	Required for maturation of 30S ribosomal subunits
CXD80_RS13400	COG1187	pseudouridine synthase activity
CXD80_RS13405	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CXD80_RS13415	COG0583	DNA-binding transcription factor activity
CXD80_RS13425	COG0523	cobalamin synthesis protein
CXD80_RS13445	COG0625	glutathione transferase activity
CXD80_RS13450	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CXD80_RS13455	COG1047	Peptidyl-prolyl cis-trans
CXD80_RS13460	COG2003	Belongs to the UPF0758 family
CXD80_RS13465	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CXD80_RS13470	COG3483	tryptophan 2,3-dioxygenase activity
CXD80_RS13475	COG0254	rRNA binding
CXD80_RS13485	COG0534	Mate efflux family protein
CXD80_RS13505	COG2304	oxidoreductase activity
CXD80_RS13525	COG1028	Short-chain dehydrogenase reductase Sdr
CXD80_RS13530	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CXD80_RS13535	COG1562	ergosterol biosynthetic process
CXD80_RS13540	COG1562	ergosterol biosynthetic process
CXD80_RS13545	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CXD80_RS13545	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CXD80_RS13550	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CXD80_RS13560	COG0842	Transport permease protein
CXD80_RS13565	COG1131	(ABC) transporter
CXD80_RS13585	COG1477	protein flavinylation
CXD80_RS13600	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CXD80_RS13615	COG5564	TIM-barrel signal transduction protein
CXD80_RS13620	COG5441	Belongs to the UPF0261 family
CXD80_RS13630	COG3468	outer membrane autotransporter barrel domain protein
CXD80_RS13650	COG0542	response to heat
CXD80_RS13655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CXD80_RS13670	COG0494	nUDIX hydrolase
CXD80_RS13675	COG3530	Putative quorum-sensing-regulated virulence factor
CXD80_RS13685	COG1595	DNA-templated transcription, initiation
CXD80_RS13690	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CXD80_RS13725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD80_RS13730	COG0765	amino acid transport
CXD80_RS13735	COG0765	amino acid transport
CXD80_RS13760	COG2988	succinylglutamate desuccinylase activity
CXD80_RS13785	COG3181	Tripartite tricarboxylate transporter family receptor
CXD80_RS13790	COG2084	Dehydrogenase
CXD80_RS13805	COG1619	proteins homologs of microcin C7 resistance protein MccF
CXD80_RS13820	COG2814	Major facilitator Superfamily
CXD80_RS13830	COG0583	DNA-binding transcription factor activity
CXD80_RS13870	COG0672	)-iron permease
CXD80_RS13885	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
CXD80_RS13890	COG1028	Short-chain dehydrogenase reductase Sdr
CXD80_RS13895	COG3243	poly(R)-hydroxyalkanoic acid synthase
CXD80_RS13905	COG0564	pseudouridine synthase activity
CXD80_RS13915	COG1199	ATP-dependent helicase activity
CXD80_RS13920	COG2183	response to ionizing radiation
CXD80_RS13925	COG0180	Tryptophanyl-tRNA synthetase
CXD80_RS13950	COG3181	Tripartite tricarboxylate transporter family receptor
CXD80_RS13960	COG0583	DNA-binding transcription factor activity
CXD80_RS13965	COG1028	Short-chain dehydrogenase reductase Sdr
CXD80_RS13970	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CXD80_RS13975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CXD80_RS13980	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXD80_RS13985	COG0567	Dehydrogenase, E1 component
CXD80_RS13995	COG1522	sequence-specific DNA binding
CXD80_RS14005	COG0281	malic enzyme
CXD80_RS14005	COG0280	phosphate acetyltransferase
CXD80_RS14010	COG3539	Fimbrial protein
CXD80_RS14030	COG0613	PHP domain protein
CXD80_RS14040	COG2333	competence protein COMEC
CXD80_RS14040	COG0658	competence protein
CXD80_RS14065	COG0084	hydrolase, TatD family'
CXD80_RS14070	COG1136	(ABC) transporter
CXD80_RS14085	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CXD80_RS14095	COG1028	Short-chain dehydrogenase reductase Sdr
CXD80_RS14100	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CXD80_RS14115	COG1022	Amp-dependent synthetase and ligase
CXD80_RS14150	COG2205	protein histidine kinase activity
CXD80_RS14155	COG0745	RESPONSE REGULATOR receiver
CXD80_RS14160	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CXD80_RS14170	COG1295	ribonuclease BN
CXD80_RS14185	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CXD80_RS14215	COG1534	Rna-binding protein
CXD80_RS14220	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CXD80_RS14225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CXD80_RS14235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CXD80_RS14245	COG0248	Ppx GppA phosphatase
CXD80_RS14270	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CXD80_RS14285	COG2732	(Barnase) inhibitor
CXD80_RS14295	COG0280	phosphate acetyltransferase
CXD80_RS14295	COG0281	malic enzyme
CXD80_RS14305	COG0436	Aminotransferase
CXD80_RS14315	COG0741	lytic transglycosylase activity
CXD80_RS14320	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CXD80_RS14345	COG1648	precorrin-2 dehydrogenase activity
CXD80_RS14345	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CXD80_RS14350	COG3468	outer membrane autotransporter barrel domain protein
CXD80_RS14360	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CXD80_RS14365	COG2027	D-alanyl-D-alanine carboxypeptidase
CXD80_RS14370	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CXD80_RS14375	COG0343	queuine tRNA-ribosyltransferase activity
CXD80_RS14380	COG1862	Preprotein translocase
CXD80_RS14385	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CXD80_RS14390	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CXD80_RS14405	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CXD80_RS14410	COG1702	phosphate starvation-inducible protein PhoH
CXD80_RS14415	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CXD80_RS14420	COG4535	Mg2 and Co2 transporter CorC
CXD80_RS14430	COG0667	Aldo Keto reductase
CXD80_RS14455	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CXD80_RS14460	COG0745	RESPONSE REGULATOR receiver
CXD80_RS14465	COG2201	protein-glutamate methylesterase activity
CXD80_RS14475	COG0840	transmembrane signaling receptor activity
CXD80_RS14490	COG0745	RESPONSE REGULATOR receiver
CXD80_RS14525	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CXD80_RS14535	COG0739	heme binding
CXD80_RS14545	COG0521	Mo-molybdopterin cofactor biosynthetic process
CXD80_RS14555	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CXD80_RS14585	COG0625	glutathione transferase activity
CXD80_RS14600	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CXD80_RS14605	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CXD80_RS14610	COG0126	phosphoglycerate kinase activity
CXD80_RS14615	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CXD80_RS14620	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CXD80_RS14625	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CXD80_RS14635	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CXD80_RS14640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CXD80_RS14645	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXD80_RS14650	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CXD80_RS14660	COG4566	intracellular signal transduction
CXD80_RS14665	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CXD80_RS14670	COG0339	signal peptide processing
CXD80_RS14675	COG1999	signal sequence binding
CXD80_RS14705	COG1187	pseudouridine synthase activity
CXD80_RS14710	COG3161	chorismate lyase activity
CXD80_RS14725	COG0667	Aldo Keto reductase
CXD80_RS14740	COG0335	large ribosomal subunit rRNA binding
CXD80_RS14775	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CXD80_RS14795	COG0450	alkyl hydroperoxide reductase
CXD80_RS14800	COG1960	acyl-CoA dehydrogenase activity
CXD80_RS14815	COG0123	including yeast histone deacetylase and acetoin utilization protein
CXD80_RS14820	COG2951	lytic endotransglycosylase activity
CXD80_RS14835	COG1555	photosystem II stabilization
CXD80_RS14835	COG1596	polysaccharide export
CXD80_RS14840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CXD80_RS14845	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CXD80_RS14850	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CXD80_RS14870	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CXD80_RS14875	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CXD80_RS14880	COG0287	Prephenate dehydrogenase
CXD80_RS14890	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CXD80_RS14905	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CXD80_RS14915	COG2814	Major facilitator Superfamily
CXD80_RS14950	COG0583	DNA-binding transcription factor activity
CXD80_RS14990	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CXD80_RS15005	COG0667	Aldo Keto reductase
CXD80_RS15015	COG5265	(ABC) transporter
CXD80_RS15065	COG0439	Biotin carboxylase
CXD80_RS15070	COG2188	Transcriptional regulator
CXD80_RS15095	COG0511	ligase activity, forming carbon-carbon bonds
CXD80_RS15105	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CXD80_RS15125	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CXD80_RS15145	COG0500	methyltransferase
CXD80_RS15150	COG5265	(ABC) transporter
CXD80_RS15165	COG0028	Belongs to the TPP enzyme family
CXD80_RS15170	COG0440	acetolactate synthase activity
CXD80_RS15175	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CXD80_RS15180	COG1183	phosphatidylcholine synthase activity
CXD80_RS15195	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CXD80_RS15200	COG1185	polyribonucleotide nucleotidyltransferase activity
CXD80_RS15215	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CXD80_RS15235	COG0149	triose-phosphate isomerase activity
CXD80_RS15240	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CXD80_RS15250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CXD80_RS15260	COG3799	methylaspartate ammonia-lyase activity
CXD80_RS15295	COG0583	DNA-binding transcription factor activity
CXD80_RS15300	COG0626	cystathionine gamma-synthase activity
CXD80_RS15305	COG3608	succinylglutamate desuccinylase aspartoacylase
CXD80_RS15325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD80_RS15345	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
CXD80_RS15360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CXD80_RS15365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CXD80_RS15370	COG1733	regulation of RNA biosynthetic process
CXD80_RS15380	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CXD80_RS15385	COG0583	DNA-binding transcription factor activity
CXD80_RS15390	COG1597	lipid kinase activity
CXD80_RS15400	COG0671	phosphoesterase, PA-phosphatase related
CXD80_RS15430	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CXD80_RS15435	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CXD80_RS15440	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CXD80_RS15445	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CXD80_RS15450	COG0649	NAD binding
CXD80_RS15455	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CXD80_RS15465	COG1034	ATP synthesis coupled electron transport
CXD80_RS15470	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CXD80_RS15475	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CXD80_RS15485	COG0713	ATP synthesis coupled electron transport
CXD80_RS15500	COG1007	ATP synthesis coupled electron transport
CXD80_RS15510	COG4774	siderophore transport
CXD80_RS15515	COG4774	siderophore transport
CXD80_RS15530	COG0028	Belongs to the TPP enzyme family
CXD80_RS15535	COG3181	Tripartite tricarboxylate transporter family receptor
CXD80_RS15540	COG0583	DNA-binding transcription factor activity
CXD80_RS15545	COG0560	Phosphoserine phosphatase
CXD80_RS15550	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CXD80_RS15555	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CXD80_RS15560	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CXD80_RS15575	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CXD80_RS15580	COG0308	aminopeptidase N
CXD80_RS15600	COG0028	Belongs to the TPP enzyme family
CXD80_RS15620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD80_RS15630	COG0318	PFAM AMP-dependent synthetase and ligase
CXD80_RS15640	COG1802	Transcriptional regulator
CXD80_RS15650	COG1802	Transcriptional regulator
CXD80_RS15660	COG1028	Short-chain dehydrogenase reductase Sdr
CXD80_RS15680	COG1126	abc transporter atp-binding protein
CXD80_RS15685	COG0765	amino acid transport
CXD80_RS15705	COG1538	Outer membrane efflux protein
CXD80_RS15710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CXD80_RS15715	COG2274	protein secretion by the type I secretion system
CXD80_RS15720	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CXD80_RS15730	COG2994	toxin metabolic process
CXD80_RS15750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD80_RS15755	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
CXD80_RS15765	COG0583	DNA-binding transcription factor activity
CXD80_RS15775	COG0142	geranyltranstransferase activity
CXD80_RS15785	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CXD80_RS15790	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CXD80_RS15795	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CXD80_RS15800	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CXD80_RS15845	COG3712	iron ion homeostasis
CXD80_RS15850	COG4774	siderophore transport
CXD80_RS15855	COG2353	YceI-like domain
CXD80_RS15870	COG0019	diaminopimelate decarboxylase activity
CXD80_RS15890	COG0747	negative chemotaxis
CXD80_RS15895	COG0601	transmembrane transport
CXD80_RS15900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD80_RS15910	COG0154	amidase activity
CXD80_RS15915	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CXD80_RS15940	COG2154	pterin-4-alpha-carbinolamine dehydratase
CXD80_RS15950	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CXD80_RS15960	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CXD80_RS15965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CXD80_RS15970	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CXD80_RS15975	COG1929	Belongs to the glycerate kinase type-1 family
CXD80_RS15980	COG0469	pyruvate kinase activity
CXD80_RS15985	COG0700	Nucleoside recognition
CXD80_RS16020	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CXD80_RS16025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXD80_RS16040	COG0823	Involved in the tonB-independent uptake of proteins
CXD80_RS16050	COG0848	biopolymer transport protein
CXD80_RS16055	COG0811	peptide transport
CXD80_RS16060	COG0824	Thioesterase
CXD80_RS16065	COG0442	prolyl-tRNA aminoacylation
CXD80_RS16070	COG0494	nUDIX hydrolase
CXD80_RS16085	COG2135	peptidase activity
CXD80_RS16160	COG1196	nuclear chromosome segregation
CXD80_RS16300	COG1464	Belongs to the NlpA lipoprotein family
CXD80_RS16330	COG4211	Belongs to the binding-protein-dependent transport system permease family
CXD80_RS16340	COG0154	amidase activity
CXD80_RS16345	COG0288	reversible hydration of carbon dioxide
CXD80_RS16360	COG0514	ATP-dependent DNA helicase (RecQ)
CXD80_RS16365	COG2255	four-way junction helicase activity
CXD80_RS16380	COG0632	four-way junction helicase activity
CXD80_RS16385	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CXD80_RS16405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CXD80_RS16415	COG0006	proline dipeptidase activity
CXD80_RS16440	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CXD80_RS16455	COG4783	chaperone-mediated protein folding
CXD80_RS16460	COG0429	hydrolase of the alpha beta-hydrolase fold
CXD80_RS16490	COG0513	Belongs to the DEAD box helicase family
CXD80_RS16510	COG1546	Belongs to the CinA family
CXD80_RS16510	COG1058	Belongs to the CinA family
CXD80_RS16515	COG1414	Transcriptional regulator
CXD80_RS16535	COG0167	dihydroorotate dehydrogenase activity
CXD80_RS16540	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CXD80_RS16555	COG0583	DNA-binding transcription factor activity
CXD80_RS16615	COG0280	phosphate acetyltransferase
CXD80_RS16615	COG0281	malic enzyme
CXD80_RS16625	COG0601	transmembrane transport
CXD80_RS16630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD80_RS16635	COG4172	Belongs to the ABC transporter superfamily
CXD80_RS16665	COG0640	Transcriptional regulator
CXD80_RS16680	COG3135	benzoate transporter
CXD80_RS16685	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CXD80_RS16690	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CXD80_RS16695	COG0742	ribosomal rna small subunit methyltransferase
CXD80_RS16710	COG3639	organic phosphonate transmembrane transporter activity
CXD80_RS16715	COG3639	organic phosphonate transmembrane transporter activity
CXD80_RS16755	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CXD80_RS16760	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CXD80_RS16770	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CXD80_RS16775	COG1058	Belongs to the CinA family
CXD80_RS16775	COG1546	Belongs to the CinA family
CXD80_RS16780	COG0284	orotidine-5'-phosphate decarboxylase activity
CXD80_RS16785	COG1252	NADH dehydrogenase
CXD80_RS16800	COG3468	outer membrane autotransporter barrel domain protein
CXD80_RS16805	COG0459	protein refolding
CXD80_RS16810	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CXD80_RS16830	COG1053	succinate dehydrogenase
CXD80_RS16845	COG0583	DNA-binding transcription factor activity
CXD80_RS16850	COG1053	succinate dehydrogenase
CXD80_RS16875	COG3706	GGDEF domain
CXD80_RS16915	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CXD80_RS16925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXD80_RS16935	COG0069	glutamate synthase activity
CXD80_RS16940	COG2391	methyltransferase activity
CXD80_RS16945	COG0679	Auxin Efflux Carrier
CXD80_RS16970	COG0557	exoribonuclease II activity
CXD80_RS16975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CXD80_RS16985	COG3128	pkhd-type hydroxylase
CXD80_RS16990	COG0776	regulation of translation
CXD80_RS17020	COG0642	Histidine kinase
CXD80_RS17025	COG3158	transport of potassium into the cell
CXD80_RS17030	COG0137	argininosuccinate synthase activity
CXD80_RS17035	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CXD80_RS17040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CXD80_RS17050	COG0583	DNA-binding transcription factor activity
CXD80_RS17060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CXD80_RS17080	COG2186	Transcriptional regulator
CXD80_RS17090	COG2223	nitrite transmembrane transporter activity
CXD80_RS17100	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CXD80_RS17105	COG0450	alkyl hydroperoxide reductase
CXD80_RS17125	COG1214	PFAM Peptidase M22, glycoprotease
CXD80_RS17130	COG1573	uracil-dna glycosylase
CXD80_RS17135	COG0477	Major facilitator Superfamily
CXD80_RS17140	COG1196	nuclear chromosome segregation
CXD80_RS17150	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CXD80_RS17155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CXD80_RS17170	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CXD80_RS17175	COG1122	ATPase activity
CXD80_RS17180	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CXD80_RS17185	COG1268	BioY protein
CXD80_RS17205	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CXD80_RS17240	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CXD80_RS17245	COG2878	Part of a membrane complex involved in electron transport
CXD80_RS17260	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CXD80_RS17265	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CXD80_RS17270	COG0251	oxidation-reduction process
CXD80_RS17280	COG3228	Belongs to the MtfA family
CXD80_RS17285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CXD80_RS17295	COG0133	tryptophan synthase activity
CXD80_RS17300	COG0159	tryptophan synthase activity
CXD80_RS17305	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CXD80_RS17325	COG1530	ribonuclease E activity
CXD80_RS17335	COG0546	phosphoglycolate phosphatase activity
CXD80_RS17340	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CXD80_RS17345	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CXD80_RS17370	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD80_RS17375	COG0583	DNA-binding transcription factor activity
CXD80_RS17385	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD80_RS17405	COG0251	oxidation-reduction process
CXD80_RS17410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CXD80_RS17410	COG1017	nitric oxide dioxygenase activity
CXD80_RS17415	COG2031	fatty acid transporter
CXD80_RS17420	COG1012	belongs to the aldehyde dehydrogenase family
CXD80_RS17425	COG1802	Transcriptional regulator
CXD80_RS17435	COG1278	Cold shock
CXD80_RS17440	COG0583	DNA-binding transcription factor activity
CXD80_RS17465	COG0183	Belongs to the thiolase family
CXD80_RS17475	COG1960	acyl-CoA dehydrogenase activity
CXD80_RS17480	COG0583	DNA-binding transcription factor activity
CXD80_RS17485	COG3181	Tripartite tricarboxylate transporter family receptor
CXD80_RS17490	COG1024	Enoyl-CoA hydratase
CXD80_RS17495	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD80_RS17500	COG1253	flavin adenine dinucleotide binding
CXD80_RS17505	COG1285	pathogenesis
CXD80_RS17515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXD80_RS17530	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CXD80_RS17540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXD80_RS17550	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD80_RS17555	COG3181	Tripartite tricarboxylate transporter family receptor
CXD80_RS17560	COG1960	acyl-CoA dehydrogenase activity
CXD80_RS17580	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CXD80_RS17585	COG1024	Enoyl-CoA hydratase
CXD80_RS17590	COG1960	acyl-CoA dehydrogenase activity
CXD80_RS17610	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CXD80_RS17615	COG0022	dehydrogenase e1 component
CXD80_RS17620	COG1024	Enoyl-CoA hydratase
CXD80_RS17625	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXD80_RS17645	COG0683	leucine binding
CXD80_RS17650	COG0559	Belongs to the binding-protein-dependent transport system permease family
CXD80_RS17655	COG0411	ABC transporter
CXD80_RS17665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CXD80_RS17680	COG3181	Tripartite tricarboxylate transporter family receptor
CXD80_RS17710	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CXD80_RS17715	COG0793	Belongs to the peptidase S41A family
CXD80_RS17720	COG4942	peptidase
CXD80_RS17725	COG0588	phosphoglycerate mutase activity
CXD80_RS17730	COG1054	Belongs to the UPF0176 family
CXD80_RS17735	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CXD80_RS17740	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CXD80_RS17745	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CXD80_RS17750	COG3181	Tripartite tricarboxylate transporter family receptor
CXD80_RS17765	COG2226	methyltransferase
CXD80_RS17770	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CXD80_RS17785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD80_RS17790	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CXD80_RS17815	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CXD80_RS17840	COG1335	isochorismatase
CXD80_RS17845	COG2309	aminopeptidase activity
CXD80_RS17855	COG3473	Maleate cis-trans isomerase
CXD80_RS17865	COG2068	MobA-Related Protein
CXD80_RS17890	COG2204	response regulator
CXD80_RS17895	COG5000	phosphorelay sensor kinase activity
CXD80_RS17905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CXD80_RS17905	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CXD80_RS17915	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CXD80_RS17950	COG0583	DNA-binding transcription factor activity
CXD80_RS17970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXD80_RS17975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD80_RS17990	COG0758	DNA mediated transformation
CXD80_RS17995	COG1522	sequence-specific DNA binding
CXD80_RS18005	COG0242	peptide deformylase activity
CXD80_RS18020	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CXD80_RS18030	COG0546	phosphoglycolate phosphatase activity
CXD80_RS18050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CXD80_RS18055	COG1942	4-Oxalocrotonate Tautomerase
CXD80_RS18060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD80_RS18085	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CXD80_RS18105	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CXD80_RS18110	COG1024	Enoyl-CoA hydratase
CXD80_RS18115	COG1414	Transcriptional regulator
CXD80_RS18120	COG0318	PFAM AMP-dependent synthetase and ligase
CXD80_RS18125	COG3181	Tripartite tricarboxylate transporter family receptor
CXD80_RS18170	COG3422	double-strand break repair
CXD80_RS18175	COG0330	HflC and HflK could
CXD80_RS18185	COG0251	oxidation-reduction process
CXD80_RS18235	COG3723	Recombinational DNA repair protein, rece pathway
CXD80_RS18270	COG0582	viral genome integration into host DNA
CXD80_RS18305	COG0706	membrane insertase activity
CXD80_RS18310	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CXD80_RS18315	COG0594	ribonuclease P activity
CXD80_RS18320	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CXD80_RS18325	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CXD80_RS18340	COG1414	Transcriptional regulator
CXD80_RS18345	COG0154	amidase activity
CXD80_RS18360	COG1304	FMN binding
CXD80_RS18410	COG0183	Belongs to the thiolase family
CXD80_RS18415	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CXD80_RS18430	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CXD80_RS18435	COG3181	Tripartite tricarboxylate transporter family receptor
CXD80_RS18445	COG2358	TRAP transporter, solute receptor (TAXI family
CXD80_RS18455	COG1629	transport
CXD80_RS18460	COG2922	Belongs to the Smg family
CXD80_RS18485	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CXD80_RS18490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD80_RS18495	COG1028	Short-chain dehydrogenase reductase Sdr
CXD80_RS18500	COG1012	belongs to the aldehyde dehydrogenase family
CXD80_RS18510	COG0028	Belongs to the TPP enzyme family
CXD80_RS18515	COG1522	sequence-specific DNA binding
CXD80_RS18520	COG3781	membrane
CXD80_RS18530	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CXD80_RS18550	COG4206	TonB-dependent receptor
CXD80_RS18555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CXD80_RS18560	COG2022	thiamine diphosphate biosynthetic process
CXD80_RS18565	COG0351	phosphomethylpyrimidine kinase
CXD80_RS18570	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CXD80_RS18585	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CXD80_RS18595	COG0628	permease
CXD80_RS18605	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CXD80_RS18620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CXD80_RS18625	COG0049	tRNA binding
CXD80_RS18630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CXD80_RS18635	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CXD80_RS18640	COG0051	transcription antitermination factor activity, RNA binding
CXD80_RS18645	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CXD80_RS18650	COG0088	Forms part of the polypeptide exit tunnel
CXD80_RS18655	COG0089	rRNA binding
CXD80_RS18660	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CXD80_RS18665	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CXD80_RS18670	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CXD80_RS18675	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CXD80_RS18680	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CXD80_RS18685	COG0255	Belongs to the universal ribosomal protein uL29 family
CXD80_RS18690	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CXD80_RS18710	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CXD80_RS18715	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CXD80_RS18720	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CXD80_RS18725	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CXD80_RS18730	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CXD80_RS18735	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CXD80_RS18740	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CXD80_RS18745	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CXD80_RS18750	COG1841	ribosomal large subunit assembly
CXD80_RS18755	COG0200	Binds to the 23S rRNA
CXD80_RS18760	COG0201	protein transport
CXD80_RS18765	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CXD80_RS18770	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CXD80_RS18775	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CXD80_RS18780	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CXD80_RS18785	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CXD80_RS18790	COG0202	RNA polymerase activity
CXD80_RS18795	COG0203	ribosomal protein L17
CXD80_RS18800	COG0537	adenosine 5'-monophosphoramidase activity
CXD80_RS18805	COG1324	tolerance protein
CXD80_RS18810	COG4232	protein-disulfide reductase activity
CXD80_RS18825	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CXD80_RS18835	COG1333	cytochrome c biogenesis protein
CXD80_RS18840	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CXD80_RS18855	COG1965	Belongs to the frataxin family
CXD80_RS18865	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CXD80_RS18870	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CXD80_RS18875	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CXD80_RS18890	COG2814	Major facilitator Superfamily
CXD80_RS18895	COG0629	single-stranded DNA binding
CXD80_RS18935	COG0402	S-adenosylhomocysteine deaminase activity
CXD80_RS18945	COG0438	transferase activity, transferring glycosyl groups
CXD80_RS18965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD80_RS18990	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CXD80_RS19015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXD80_RS19020	COG1956	GAF domain-containing protein
CXD80_RS19025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXD80_RS19040	COG1652	LysM domain
CXD80_RS19055	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CXD80_RS19070	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CXD80_RS19100	COG3181	Tripartite tricarboxylate transporter family receptor
CXD80_RS19115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD80_RS19130	COG1024	Enoyl-CoA hydratase
CXD80_RS19145	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD80_RS19150	COG1309	transcriptional regulator
CXD80_RS19155	COG2816	NAD+ diphosphatase activity
CXD80_RS19160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CXD80_RS19245	COG2814	Major facilitator Superfamily
CXD80_RS19250	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CXD80_RS19270	COG1999	signal sequence binding
CXD80_RS19275	COG0109	protoheme IX farnesyltransferase activity
CXD80_RS19315	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CXD80_RS19335	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CXD80_RS19340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CXD80_RS19350	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CXD80_RS19355	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CXD80_RS19365	COG0067	glutamate synthase
CXD80_RS19365	COG0069	glutamate synthase activity
CXD80_RS19365	COG0070	glutamate synthase
CXD80_RS19375	COG3047	cAMP biosynthetic process
CXD80_RS19385	COG1127	ABC transporter
CXD80_RS19390	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CXD80_RS19395	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CXD80_RS19400	COG2853	Lipoprotein
CXD80_RS19415	COG0842	Transport permease protein
CXD80_RS19425	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CXD80_RS19430	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CXD80_RS19435	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CXD80_RS19440	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CXD80_RS19445	COG0131	Imidazoleglycerol-phosphate dehydratase
CXD80_RS19450	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CXD80_RS19455	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CXD80_RS19460	COG0107	imidazoleglycerol-phosphate synthase activity
CXD80_RS19465	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CXD80_RS19470	COG0140	phosphoribosyl-ATP diphosphatase activity
CXD80_RS19475	COG0537	adenosine 5'-monophosphoramidase activity
CXD80_RS19480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CXD80_RS19485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CXD80_RS19500	COG3181	Tripartite tricarboxylate transporter family receptor
CXD80_RS19535	COG3702	type iv secretory pathway
CXD80_RS19540	COG3451	type IV secretory pathway VirB4
CXD80_RS19555	COG3736	Type IV secretory pathway, component VirB8
CXD80_RS19560	COG3504	Conjugal transfer protein
CXD80_RS19565	COG2948	multi-organism process
CXD80_RS19570	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
CXD80_RS19580	COG0697	spore germination
CXD80_RS19600	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CXD80_RS19605	COG0747	negative chemotaxis
CXD80_RS19610	COG0601	transmembrane transport
CXD80_RS19615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD80_RS19630	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CXD80_RS19640	COG0494	nUDIX hydrolase
CXD80_RS19685	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CXD80_RS19690	COG0237	dephospho-CoA kinase activity
CXD80_RS19695	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CXD80_RS19710	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CXD80_RS19715	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CXD80_RS19725	COG0477	Major facilitator Superfamily
CXD80_RS19730	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CXD80_RS19745	COG1126	abc transporter atp-binding protein
CXD80_RS19750	COG0765	amino acid transport
CXD80_RS19755	COG4597	amino acid ABC transporter
CXD80_RS19760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD80_RS19765	COG2884	Cell division ATP-binding protein ftsE
CXD80_RS19770	COG2177	Part of the ABC transporter FtsEX involved in
CXD80_RS19775	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CXD80_RS19785	COG1194	a g-specific adenine glycosylase
CXD80_RS19795	COG2226	methyltransferase
CXD80_RS19805	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD80_RS19810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD80_RS19825	COG1024	Enoyl-CoA hydratase
CXD80_RS19845	COG1024	Enoyl-CoA hydratase
CXD80_RS19850	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD80_RS19865	COG0753	catalase activity
CXD80_RS19870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD80_RS19875	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CXD80_RS19885	COG2175	clavaminate synthase activity
CXD80_RS19890	COG1473	amidohydrolase
CXD80_RS19895	COG4608	Belongs to the ABC transporter superfamily
CXD80_RS19900	COG0444	Belongs to the ABC transporter superfamily
CXD80_RS19915	COG0747	negative chemotaxis
CXD80_RS19920	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CXD80_RS19955	COG0436	Aminotransferase
CXD80_RS19960	COG1278	Cold shock