locus-tag	class	description
RD16_RS00005	COG0445	tRNA wobble uridine modification
RD16_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
RD16_RS00015	COG1192	Involved in chromosome partitioning
RD16_RS00025	COG1475	DNA binding
RD16_RS00030	COG0252	asparaginase activity
RD16_RS00055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RD16_RS00065	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RD16_RS00075	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RD16_RS00080	COG0081	regulation of translation
RD16_RS00085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RD16_RS00090	COG0222	ribosome binding
RD16_RS00095	COG0085	RNA polymerase activity
RD16_RS00100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RD16_RS00140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD16_RS00165	COG1024	Enoyl-CoA hydratase
RD16_RS00185	COG0752	glycyl-tRNA synthetase alpha subunit
RD16_RS00190	COG0751	glycine-tRNA ligase activity
RD16_RS00195	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RD16_RS00200	COG0204	Acyl-transferase
RD16_RS00215	COG0242	peptide deformylase activity
RD16_RS00255	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RD16_RS00260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RD16_RS00265	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RD16_RS00265	COG2813	Specifically methylates the guanine in position
RD16_RS00275	COG2223	nitrite transmembrane transporter activity
RD16_RS00285	COG1794	racemase activity, acting on amino acids and derivatives
RD16_RS00290	COG1126	abc transporter atp-binding protein
RD16_RS00295	COG0765	amino acid transport
RD16_RS00300	COG0765	amino acid transport
RD16_RS00305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD16_RS00365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD16_RS00395	COG0326	Molecular chaperone. Has ATPase activity
RD16_RS00400	COG0625	glutathione transferase activity
RD16_RS00415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RD16_RS00420	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RD16_RS00450	COG0438	transferase activity, transferring glycosyl groups
RD16_RS00455	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RD16_RS00460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RD16_RS00490	COG0859	PFAM glycosyl transferase family 9
RD16_RS00505	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
RD16_RS00515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RD16_RS00520	COG1127	ABC transporter
RD16_RS00545	COG1686	Belongs to the peptidase S11 family
RD16_RS00555	COG2921	Belongs to the UPF0250 family
RD16_RS00560	COG0321	lipoyl(octanoyl) transferase activity
RD16_RS00565	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RD16_RS00600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RD16_RS00610	COG0018	arginyl-trna synthetase
RD16_RS00630	COG0395	ABC-type sugar transport system, permease component
RD16_RS00635	COG1175	transmembrane transport
RD16_RS00640	COG1653	transport
RD16_RS00645	COG3842	ATPase activity
RD16_RS00650	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RD16_RS00665	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RD16_RS00685	COG1609	Transcriptional regulator
RD16_RS00695	COG0154	amidase activity
RD16_RS00700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RD16_RS00710	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RD16_RS00720	COG0583	DNA-binding transcription factor activity
RD16_RS00735	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RD16_RS00740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RD16_RS00755	COG1802	Transcriptional regulator
RD16_RS00770	COG1024	Enoyl-CoA hydratase
RD16_RS00785	COG3181	Tripartite tricarboxylate transporter family receptor
RD16_RS00800	COG1984	allophanate hydrolase subunit 2
RD16_RS00805	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RD16_RS00815	COG0583	DNA-binding transcription factor activity
RD16_RS00820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RD16_RS00830	COG5002	protein histidine kinase activity
RD16_RS00840	COG5002	protein histidine kinase activity
RD16_RS00845	COG0745	RESPONSE REGULATOR receiver
RD16_RS00850	COG2226	methyltransferase
RD16_RS00865	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RD16_RS00885	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
RD16_RS00895	COG0513	Belongs to the DEAD box helicase family
RD16_RS00900	COG1280	lysine exporter protein (LysE YggA)
RD16_RS00905	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
RD16_RS00940	COG1054	Belongs to the UPF0176 family
RD16_RS00945	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RD16_RS00945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RD16_RS00955	COG0489	protein tyrosine kinase activity
RD16_RS00970	COG0717	Belongs to the dCTP deaminase family
RD16_RS01000	COG2081	HI0933 family
RD16_RS01010	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RD16_RS01020	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RD16_RS01025	COG0509	glycine decarboxylation via glycine cleavage system
RD16_RS01030	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RD16_RS01030	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RD16_RS01070	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RD16_RS01075	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
RD16_RS01080	COG1012	belongs to the aldehyde dehydrogenase family
RD16_RS01105	COG4257	antibiotic catabolic process
RD16_RS01115	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
RD16_RS01120	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
RD16_RS01130	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD16_RS01135	COG2031	fatty acid transporter
RD16_RS01140	COG1028	Short-chain dehydrogenase reductase Sdr
RD16_RS01145	COG1414	Transcriptional regulator
RD16_RS01155	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RD16_RS01170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RD16_RS01190	COG1028	Short-chain dehydrogenase reductase Sdr
RD16_RS01200	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RD16_RS01210	COG2188	Transcriptional regulator
RD16_RS01215	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD16_RS01240	COG0617	tRNA 3'-terminal CCA addition
RD16_RS01255	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RD16_RS01260	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RD16_RS01265	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RD16_RS01270	COG0586	Pfam SNARE associated Golgi protein
RD16_RS01275	COG0860	N-Acetylmuramoyl-L-alanine amidase
RD16_RS01280	COG0802	atpase or kinase
RD16_RS01285	COG0114	fumarate hydratase activity
RD16_RS01295	COG3181	Tripartite tricarboxylate transporter family receptor
RD16_RS01305	COG0405	Gamma-glutamyltransferase
RD16_RS01310	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD16_RS01320	COG1960	acyl-CoA dehydrogenase activity
RD16_RS01345	COG1294	oxidase, subunit
RD16_RS01355	COG4988	ABC transporter
RD16_RS01360	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
RD16_RS01365	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RD16_RS01380	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RD16_RS01405	COG2969	positive regulation of protein catabolic process
RD16_RS01410	COG0625	glutathione transferase activity
RD16_RS01415	COG2857	Cytochrome c1
RD16_RS01420	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RD16_RS01425	COG0723	plastoquinol--plastocyanin reductase activity
RD16_RS01430	COG1970	mechanosensitive ion channel activity
RD16_RS01435	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RD16_RS01450	COG2808	Putative FMN-binding domain
RD16_RS01455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RD16_RS01460	COG0747	negative chemotaxis
RD16_RS01465	COG0657	acetylesterase activity
RD16_RS01475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RD16_RS01480	COG2207	Transcriptional regulator
RD16_RS01485	COG0129	dihydroxy-acid dehydratase activity
RD16_RS01490	COG2814	Major facilitator Superfamily
RD16_RS01495	COG0583	DNA-binding transcription factor activity
RD16_RS01505	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
RD16_RS01575	COG1024	Enoyl-CoA hydratase
RD16_RS01580	COG1960	acyl-CoA dehydrogenase activity
RD16_RS01605	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RD16_RS01610	COG0352	thiamine-phosphate diphosphorylase activity
RD16_RS01625	COG1678	Uncharacterized ACR, COG1678
RD16_RS01630	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RD16_RS01635	COG0540	Belongs to the ATCase OTCase family
RD16_RS01650	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RD16_RS01660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RD16_RS01695	COG1234	tRNA 3'-trailer cleavage
RD16_RS01740	COG1683	Conserved Protein
RD16_RS01745	COG1120	ATPase activity
RD16_RS01750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RD16_RS01755	COG4558	Periplasmic binding protein
RD16_RS01760	COG3720	iron ion transport
RD16_RS01770	COG3712	iron ion homeostasis
RD16_RS01775	COG1595	DNA-templated transcription, initiation
RD16_RS01810	COG1802	Transcriptional regulator
RD16_RS01820	COG3069	C4-dicarboxylate transmembrane transporter activity
RD16_RS01830	COG1012	belongs to the aldehyde dehydrogenase family
RD16_RS01865	COG2860	membrane
RD16_RS01870	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RD16_RS01875	COG0708	Exodeoxyribonuclease III
RD16_RS01880	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RD16_RS01885	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RD16_RS01890	COG0154	amidase activity
RD16_RS01895	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RD16_RS01900	COG1077	Cell shape determining protein MreB Mrl
RD16_RS01905	COG1792	Involved in formation and maintenance of cell shape
RD16_RS01915	COG0768	penicillin binding
RD16_RS01920	COG0772	Belongs to the SEDS family
RD16_RS01925	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RD16_RS01930	COG0471	metal ion transport
RD16_RS01935	COG1309	transcriptional regulator
RD16_RS01945	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RD16_RS01960	COG2823	Periplasmic or secreted lipoprotein
RD16_RS01965	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
RD16_RS01980	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RD16_RS01990	COG0697	spore germination
RD16_RS02015	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RD16_RS02020	COG0463	Glycosyl transferase, family 2
RD16_RS02035	COG0786	glutamate:sodium symporter activity
RD16_RS02045	COG2031	fatty acid transporter
RD16_RS02060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RD16_RS02065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RD16_RS02075	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RD16_RS02090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RD16_RS02100	COG1285	pathogenesis
RD16_RS02105	COG1253	flavin adenine dinucleotide binding
RD16_RS02110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD16_RS02115	COG1024	Enoyl-CoA hydratase
RD16_RS02120	COG3181	Tripartite tricarboxylate transporter family receptor
RD16_RS02125	COG0583	DNA-binding transcription factor activity
RD16_RS02130	COG1960	acyl-CoA dehydrogenase activity
RD16_RS02140	COG0183	Belongs to the thiolase family
RD16_RS02155	COG0583	DNA-binding transcription factor activity
RD16_RS02160	COG1278	Cold shock
RD16_RS02170	COG1802	Transcriptional regulator
RD16_RS02175	COG1012	belongs to the aldehyde dehydrogenase family
RD16_RS02180	COG2031	fatty acid transporter
RD16_RS02185	COG1017	nitric oxide dioxygenase activity
RD16_RS02185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RD16_RS02190	COG0251	oxidation-reduction process
RD16_RS02215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD16_RS02225	COG0583	DNA-binding transcription factor activity
RD16_RS02230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD16_RS02245	COG1960	acyl-CoA dehydrogenase activity
RD16_RS02265	COG1960	acyl-CoA dehydrogenase activity
RD16_RS02275	COG0183	Belongs to the thiolase family
RD16_RS02280	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RD16_RS02295	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RD16_RS02300	COG3181	Tripartite tricarboxylate transporter family receptor
RD16_RS02310	COG2358	TRAP transporter, solute receptor (TAXI family
RD16_RS02320	COG1629	transport
RD16_RS02325	COG2922	Belongs to the Smg family
RD16_RS02350	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
RD16_RS02355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD16_RS02360	COG1028	Short-chain dehydrogenase reductase Sdr
RD16_RS02365	COG1012	belongs to the aldehyde dehydrogenase family
RD16_RS02375	COG0028	Belongs to the TPP enzyme family
RD16_RS02380	COG1522	sequence-specific DNA binding
RD16_RS02385	COG3781	membrane
RD16_RS02395	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RD16_RS02415	COG1530	ribonuclease E activity
RD16_RS02425	COG0546	phosphoglycolate phosphatase activity
RD16_RS02430	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RD16_RS02435	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
RD16_RS02455	COG1304	FMN binding
RD16_RS02470	COG0154	amidase activity
RD16_RS02475	COG1414	Transcriptional regulator
RD16_RS02490	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RD16_RS02495	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RD16_RS02500	COG0594	ribonuclease P activity
RD16_RS02505	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RD16_RS02510	COG0706	membrane insertase activity
RD16_RS02520	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RD16_RS02545	COG0582	viral genome integration into host DNA
RD16_RS02580	COG3723	Recombinational DNA repair protein, rece pathway
RD16_RS02625	COG0251	oxidation-reduction process
RD16_RS02635	COG0330	HflC and HflK could
RD16_RS02640	COG3422	double-strand break repair
RD16_RS02655	COG0583	DNA-binding transcription factor activity
RD16_RS02685	COG3181	Tripartite tricarboxylate transporter family receptor
RD16_RS02690	COG0318	PFAM AMP-dependent synthetase and ligase
RD16_RS02695	COG1414	Transcriptional regulator
RD16_RS02700	COG1024	Enoyl-CoA hydratase
RD16_RS02705	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RD16_RS02725	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RD16_RS02745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD16_RS02750	COG1942	4-Oxalocrotonate Tautomerase
RD16_RS02755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RD16_RS02775	COG0546	phosphoglycolate phosphatase activity
RD16_RS02785	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RD16_RS02790	COG0242	peptide deformylase activity
RD16_RS02800	COG1522	sequence-specific DNA binding
RD16_RS02805	COG0758	DNA mediated transformation
RD16_RS02820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD16_RS02825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RD16_RS02830	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RD16_RS02845	COG0583	DNA-binding transcription factor activity
RD16_RS02865	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
RD16_RS02875	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RD16_RS02875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RD16_RS02885	COG5000	phosphorelay sensor kinase activity
RD16_RS02890	COG2204	response regulator
RD16_RS02915	COG2068	MobA-Related Protein
RD16_RS02925	COG3473	Maleate cis-trans isomerase
RD16_RS02930	COG0596	Alpha beta hydrolase
RD16_RS02935	COG2309	aminopeptidase activity
RD16_RS02940	COG1335	isochorismatase
RD16_RS02965	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD16_RS02990	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
RD16_RS02995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD16_RS03010	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
RD16_RS03015	COG2226	methyltransferase
RD16_RS03030	COG3181	Tripartite tricarboxylate transporter family receptor
RD16_RS03035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RD16_RS03040	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
RD16_RS03045	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RD16_RS03050	COG1054	Belongs to the UPF0176 family
RD16_RS03055	COG0588	phosphoglycerate mutase activity
RD16_RS03060	COG4942	peptidase
RD16_RS03065	COG0793	Belongs to the peptidase S41A family
RD16_RS03070	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RD16_RS03095	COG3181	Tripartite tricarboxylate transporter family receptor
RD16_RS03110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RD16_RS03120	COG0411	ABC transporter
RD16_RS03125	COG0559	Belongs to the binding-protein-dependent transport system permease family
RD16_RS03130	COG0683	leucine binding
RD16_RS03150	COG0508	dehydrogenase complex catalyzes the overall conversion of
RD16_RS03155	COG1024	Enoyl-CoA hydratase
RD16_RS03160	COG0022	dehydrogenase e1 component
RD16_RS03165	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RD16_RS03185	COG1960	acyl-CoA dehydrogenase activity
RD16_RS03190	COG1024	Enoyl-CoA hydratase
RD16_RS03195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RD16_RS03215	COG1960	acyl-CoA dehydrogenase activity
RD16_RS03220	COG3181	Tripartite tricarboxylate transporter family receptor
RD16_RS03225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD16_RS03235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RD16_RS03260	COG3181	Tripartite tricarboxylate transporter family receptor
RD16_RS03270	COG0277	FAD linked oxidase domain protein
RD16_RS03275	COG1960	acyl-CoA dehydrogenase activity
RD16_RS03280	COG1960	acyl-CoA dehydrogenase activity
RD16_RS03290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RD16_RS03305	COG2072	flavoprotein involved in K transport
RD16_RS03310	COG0604	alcohol dehydrogenase
RD16_RS03325	COG1024	Enoyl-CoA hydratase
RD16_RS03345	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RD16_RS03350	COG1522	sequence-specific DNA binding
RD16_RS03355	COG0183	Belongs to the thiolase family
RD16_RS03365	COG1960	acyl-CoA dehydrogenase activity
RD16_RS03410	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RD16_RS03415	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RD16_RS03420	COG2890	protein-(glutamine-N5) methyltransferase activity
RD16_RS03425	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
RD16_RS03435	COG3181	Tripartite tricarboxylate transporter family receptor
RD16_RS03475	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RD16_RS03480	COG1660	Displays ATPase and GTPase activities
RD16_RS03490	COG2010	Cytochrome c
RD16_RS03490	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RD16_RS03495	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
RD16_RS03505	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RD16_RS03510	COG1137	ATPase activity
RD16_RS03525	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
RD16_RS03535	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
RD16_RS03570	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RD16_RS03575	COG3568	Endonuclease Exonuclease Phosphatase
RD16_RS03580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RD16_RS03615	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RD16_RS03620	COG0154	amidase activity
RD16_RS03630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD16_RS03635	COG0601	transmembrane transport
RD16_RS03640	COG0747	negative chemotaxis
RD16_RS03660	COG0019	diaminopimelate decarboxylase activity
RD16_RS03680	COG2353	YceI-like domain
RD16_RS03685	COG4774	siderophore transport
RD16_RS03690	COG3712	iron ion homeostasis
RD16_RS03730	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RD16_RS03735	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RD16_RS03740	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RD16_RS03745	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RD16_RS03755	COG0142	geranyltranstransferase activity
RD16_RS03765	COG0583	DNA-binding transcription factor activity
RD16_RS03775	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
RD16_RS03780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD16_RS03795	COG2994	toxin metabolic process
RD16_RS03805	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
RD16_RS03810	COG2274	protein secretion by the type I secretion system
RD16_RS03815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RD16_RS03820	COG1538	Outer membrane efflux protein
RD16_RS03840	COG0765	amino acid transport
RD16_RS03845	COG1126	abc transporter atp-binding protein
RD16_RS03865	COG1028	Short-chain dehydrogenase reductase Sdr
RD16_RS03875	COG1802	Transcriptional regulator
RD16_RS03885	COG1802	Transcriptional regulator
RD16_RS03895	COG0318	PFAM AMP-dependent synthetase and ligase
RD16_RS03905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD16_RS03925	COG0028	Belongs to the TPP enzyme family
RD16_RS03945	COG0028	Belongs to the TPP enzyme family
RD16_RS03950	COG0440	acetolactate synthase activity
RD16_RS03955	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RD16_RS03960	COG1183	phosphatidylcholine synthase activity
RD16_RS03970	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RD16_RS03975	COG1185	polyribonucleotide nucleotidyltransferase activity
RD16_RS03990	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RD16_RS04010	COG0149	triose-phosphate isomerase activity
RD16_RS04015	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RD16_RS04025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RD16_RS04035	COG3799	methylaspartate ammonia-lyase activity
RD16_RS04075	COG0583	DNA-binding transcription factor activity
RD16_RS04080	COG0626	cystathionine gamma-synthase activity
RD16_RS04085	COG3608	succinylglutamate desuccinylase aspartoacylase
RD16_RS04105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD16_RS04125	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
RD16_RS04140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RD16_RS04145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RD16_RS04150	COG1733	regulation of RNA biosynthetic process
RD16_RS04160	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RD16_RS04165	COG0583	DNA-binding transcription factor activity
RD16_RS04170	COG1597	lipid kinase activity
RD16_RS04180	COG0671	phosphoesterase, PA-phosphatase related
RD16_RS04205	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RD16_RS04210	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RD16_RS04215	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RD16_RS04220	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RD16_RS04225	COG0649	NAD binding
RD16_RS04230	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
RD16_RS04240	COG1034	ATP synthesis coupled electron transport
RD16_RS04245	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
RD16_RS04250	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RD16_RS04260	COG0713	ATP synthesis coupled electron transport
RD16_RS04275	COG1007	ATP synthesis coupled electron transport
RD16_RS04285	COG4774	siderophore transport
RD16_RS04290	COG4774	siderophore transport
RD16_RS04305	COG0028	Belongs to the TPP enzyme family
RD16_RS04310	COG3181	Tripartite tricarboxylate transporter family receptor
RD16_RS04315	COG0583	DNA-binding transcription factor activity
RD16_RS04320	COG0560	Phosphoserine phosphatase
RD16_RS04325	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RD16_RS04330	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RD16_RS04335	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RD16_RS04345	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
RD16_RS04350	COG0308	aminopeptidase N
RD16_RS04365	COG5265	(ABC) transporter
RD16_RS04370	COG0500	methyltransferase
RD16_RS04385	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
RD16_RS04415	COG0511	ligase activity, forming carbon-carbon bonds
RD16_RS04440	COG2188	Transcriptional regulator
RD16_RS04445	COG0439	Biotin carboxylase
RD16_RS04450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RD16_RS04495	COG5265	(ABC) transporter
RD16_RS04505	COG0667	Aldo Keto reductase
RD16_RS04520	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RD16_RS04555	COG0583	DNA-binding transcription factor activity
RD16_RS04570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD16_RS04580	COG2079	MmgE PrpD family protein
RD16_RS04585	COG1012	belongs to the aldehyde dehydrogenase family
RD16_RS04590	COG1053	succinate dehydrogenase
RD16_RS04615	COG0179	Fumarylacetoacetate (FAA) hydrolase
RD16_RS04630	COG0583	DNA-binding transcription factor activity
RD16_RS04670	COG0583	DNA-binding transcription factor activity
RD16_RS04695	COG2814	Major facilitator Superfamily
RD16_RS04705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RD16_RS04720	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RD16_RS04730	COG0287	Prephenate dehydrogenase
RD16_RS04735	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RD16_RS04740	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RD16_RS04760	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
RD16_RS04765	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
RD16_RS04770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RD16_RS04775	COG1555	photosystem II stabilization
RD16_RS04775	COG1596	polysaccharide export
RD16_RS04790	COG2951	lytic endotransglycosylase activity
RD16_RS04795	COG0123	including yeast histone deacetylase and acetoin utilization protein
RD16_RS04810	COG1960	acyl-CoA dehydrogenase activity
RD16_RS04815	COG0450	alkyl hydroperoxide reductase
RD16_RS04830	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
RD16_RS04835	COG4208	sulfate ABC transporter
RD16_RS04840	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RD16_RS04845	COG0175	sulfate reduction
RD16_RS04875	COG0335	large ribosomal subunit rRNA binding
RD16_RS04885	COG0667	Aldo Keto reductase
RD16_RS04895	COG2814	Major facilitator Superfamily
RD16_RS04900	COG3161	chorismate lyase activity
RD16_RS04905	COG1187	pseudouridine synthase activity
RD16_RS04915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RD16_RS04935	COG1999	signal sequence binding
RD16_RS04940	COG0339	signal peptide processing
RD16_RS04945	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RD16_RS04950	COG4566	intracellular signal transduction
RD16_RS04960	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
RD16_RS04965	COG0508	dehydrogenase complex catalyzes the overall conversion of
RD16_RS04970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RD16_RS04975	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RD16_RS04985	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RD16_RS04990	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RD16_RS04995	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RD16_RS05000	COG0126	phosphoglycerate kinase activity
RD16_RS05005	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RD16_RS05010	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RD16_RS05025	COG0625	glutathione transferase activity
RD16_RS05055	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
RD16_RS05060	COG0306	phosphate transporter
RD16_RS05065	COG0521	Mo-molybdopterin cofactor biosynthetic process
RD16_RS05075	COG0739	heme binding
RD16_RS05085	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RD16_RS05120	COG0745	RESPONSE REGULATOR receiver
RD16_RS05135	COG0840	transmembrane signaling receptor activity
RD16_RS05145	COG2201	protein-glutamate methylesterase activity
RD16_RS05150	COG0745	RESPONSE REGULATOR receiver
RD16_RS05155	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
RD16_RS05180	COG0667	Aldo Keto reductase
RD16_RS05190	COG4535	Mg2 and Co2 transporter CorC
RD16_RS05195	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RD16_RS05200	COG1702	phosphate starvation-inducible protein PhoH
RD16_RS05205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RD16_RS05220	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RD16_RS05225	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RD16_RS05230	COG1862	Preprotein translocase
RD16_RS05240	COG0343	queuine tRNA-ribosyltransferase activity
RD16_RS05245	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RD16_RS05250	COG2027	D-alanyl-D-alanine carboxypeptidase
RD16_RS05255	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RD16_RS05265	COG3468	outer membrane autotransporter barrel domain protein
RD16_RS05270	COG1648	precorrin-2 dehydrogenase activity
RD16_RS05270	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RD16_RS05295	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
RD16_RS05300	COG0741	lytic transglycosylase activity
RD16_RS05305	COG0436	Aminotransferase
RD16_RS05325	COG2732	(Barnase) inhibitor
RD16_RS05340	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RD16_RS05365	COG0248	Ppx GppA phosphatase
RD16_RS05375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RD16_RS05385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RD16_RS05390	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
RD16_RS05395	COG1534	Rna-binding protein
RD16_RS05425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RD16_RS05440	COG1295	ribonuclease BN
RD16_RS05450	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
RD16_RS05455	COG0745	RESPONSE REGULATOR receiver
RD16_RS05460	COG2205	protein histidine kinase activity
RD16_RS05495	COG1022	Amp-dependent synthetase and ligase
RD16_RS05510	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RD16_RS05515	COG1028	Short-chain dehydrogenase reductase Sdr
RD16_RS05520	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RD16_RS05525	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RD16_RS05540	COG1136	(ABC) transporter
RD16_RS05545	COG0084	hydrolase, TatD family'
RD16_RS05580	COG0613	PHP domain protein
RD16_RS05595	COG3539	Fimbrial protein
RD16_RS05600	COG0281	malic enzyme
RD16_RS05600	COG0280	phosphate acetyltransferase
RD16_RS05610	COG1522	sequence-specific DNA binding
RD16_RS05615	COG1297	OPT oligopeptide transporter protein
RD16_RS05620	COG0567	Dehydrogenase, E1 component
RD16_RS05625	COG0508	dehydrogenase complex catalyzes the overall conversion of
RD16_RS05630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RD16_RS05635	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RD16_RS05640	COG1028	Short-chain dehydrogenase reductase Sdr
RD16_RS05645	COG0583	DNA-binding transcription factor activity
RD16_RS05655	COG3181	Tripartite tricarboxylate transporter family receptor
RD16_RS05680	COG1595	DNA-templated transcription, initiation
RD16_RS05685	COG3712	iron ion homeostasis
RD16_RS05690	COG4774	siderophore transport
RD16_RS05715	COG0180	Tryptophanyl-tRNA synthetase
RD16_RS05720	COG2183	response to ionizing radiation
RD16_RS05725	COG1199	ATP-dependent helicase activity
RD16_RS05735	COG0564	pseudouridine synthase activity
RD16_RS05745	COG3243	poly(R)-hydroxyalkanoic acid synthase
RD16_RS05750	COG1028	Short-chain dehydrogenase reductase Sdr
RD16_RS05755	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
RD16_RS05770	COG0672	)-iron permease
RD16_RS05810	COG0583	DNA-binding transcription factor activity
RD16_RS05820	COG2814	Major facilitator Superfamily
RD16_RS05835	COG1619	proteins homologs of microcin C7 resistance protein MccF
RD16_RS05850	COG2084	Dehydrogenase
RD16_RS05855	COG3181	Tripartite tricarboxylate transporter family receptor
RD16_RS05880	COG2988	succinylglutamate desuccinylase activity
RD16_RS05905	COG0765	amino acid transport
RD16_RS05910	COG0765	amino acid transport
RD16_RS05915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD16_RS05950	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RD16_RS05955	COG1595	DNA-templated transcription, initiation
RD16_RS05965	COG3530	Putative quorum-sensing-regulated virulence factor
RD16_RS05970	COG0494	nUDIX hydrolase
RD16_RS05985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RD16_RS05990	COG0542	response to heat
RD16_RS06000	COG3468	outer membrane autotransporter barrel domain protein
RD16_RS06005	COG3468	outer membrane autotransporter barrel domain protein
RD16_RS06015	COG5441	Belongs to the UPF0261 family
RD16_RS06020	COG5564	TIM-barrel signal transduction protein
RD16_RS06035	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
RD16_RS06050	COG1477	protein flavinylation
RD16_RS06070	COG1131	(ABC) transporter
RD16_RS06075	COG0842	Transport permease protein
RD16_RS06085	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RD16_RS06090	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
RD16_RS06090	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
RD16_RS06095	COG1562	ergosterol biosynthetic process
RD16_RS06100	COG1562	ergosterol biosynthetic process
RD16_RS06105	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RD16_RS06110	COG1028	Short-chain dehydrogenase reductase Sdr
RD16_RS06130	COG2304	oxidoreductase activity
RD16_RS06150	COG0534	Mate efflux family protein
RD16_RS06160	COG0254	rRNA binding
RD16_RS06165	COG3483	tryptophan 2,3-dioxygenase activity
RD16_RS06170	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
RD16_RS06175	COG2003	Belongs to the UPF0758 family
RD16_RS06180	COG1047	Peptidyl-prolyl cis-trans
RD16_RS06185	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RD16_RS06190	COG0625	glutathione transferase activity
RD16_RS06210	COG0523	cobalamin synthesis protein
RD16_RS06220	COG0583	DNA-binding transcription factor activity
RD16_RS06230	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RD16_RS06235	COG1187	pseudouridine synthase activity
RD16_RS06240	COG0779	Required for maturation of 30S ribosomal subunits
RD16_RS06245	COG2251	uridine kinase activity
RD16_RS06245	COG0195	Participates in both transcription termination and antitermination
RD16_RS06250	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RD16_RS06255	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RD16_RS06260	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RD16_RS06280	COG1611	Belongs to the LOG family
RD16_RS06295	COG0412	Dienelactone hydrolase
RD16_RS06300	COG1283	sodium-dependent phosphate transmembrane transporter activity
RD16_RS06305	COG1760	l-serine dehydratase
RD16_RS06310	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RD16_RS06315	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RD16_RS06325	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RD16_RS06350	COG2311	Membrane
RD16_RS06360	COG0697	spore germination
RD16_RS06375	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RD16_RS06395	COG0559	Belongs to the binding-protein-dependent transport system permease family
RD16_RS06410	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
RD16_RS06420	COG1653	transport
RD16_RS06425	COG1175	transmembrane transport
RD16_RS06430	COG0395	ABC-type sugar transport system, permease component
RD16_RS06435	COG3842	ATPase activity
RD16_RS06470	COG2363	Small membrane protein
RD16_RS06485	COG1464	Belongs to the NlpA lipoprotein family
RD16_RS06495	COG0688	phosphatidylethanolamine metabolic process
RD16_RS06510	COG0095	Lipoate-protein ligase
RD16_RS06525	COG0625	glutathione transferase activity
RD16_RS06530	COG0386	Belongs to the glutathione peroxidase family
RD16_RS06550	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD16_RS06580	COG2259	Doxx family
RD16_RS06595	COG0667	Aldo Keto reductase
RD16_RS06625	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
RD16_RS06640	COG1640	4-alpha-glucanotransferase
RD16_RS06650	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RD16_RS06660	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RD16_RS06700	COG0392	lysyltransferase activity
RD16_RS06715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RD16_RS06720	COG3568	Endonuclease Exonuclease Phosphatase
RD16_RS06725	COG1695	Transcriptional regulator
RD16_RS06745	COG0583	DNA-binding transcription factor activity
RD16_RS06760	COG1802	Transcriptional regulator
RD16_RS06770	COG3181	Tripartite tricarboxylate transporter family receptor
RD16_RS06780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD16_RS06795	COG0066	3-isopropylmalate dehydratase activity
RD16_RS06805	COG3181	Tripartite tricarboxylate transporter family receptor
RD16_RS06810	COG4948	Mandelate Racemase Muconate Lactonizing
RD16_RS06825	COG1126	abc transporter atp-binding protein
RD16_RS06830	COG0765	amino acid transport
RD16_RS06835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD16_RS06875	COG1815	bacterial-type flagellum-dependent cell motility
RD16_RS06880	COG1558	bacterial-type flagellum-dependent cell motility
RD16_RS06890	COG1749	Flagellar hook protein flgE
RD16_RS06905	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
RD16_RS06910	COG1706	bacterial-type flagellum-dependent cell motility
RD16_RS06920	COG1256	bacterial-type flagellum assembly
RD16_RS06930	COG0840	transmembrane signaling receptor activity
RD16_RS06935	COG0840	transmembrane signaling receptor activity
RD16_RS06940	COG0840	transmembrane signaling receptor activity
RD16_RS06960	COG1338	Plays a role in the flagellum-specific transport system
RD16_RS06980	COG1580	Controls the rotational direction of flagella during chemotaxis
RD16_RS07005	COG1157	protein secretion by the type III secretion system
RD16_RS07015	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RD16_RS07025	COG1677	Flagellar hook-basal body complex protein FliE
RD16_RS07035	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RD16_RS07070	COG0285	dihydrofolate synthase activity
RD16_RS07100	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
RD16_RS07105	COG0024	Methionine aminopeptidase
RD16_RS07110	COG0052	Belongs to the universal ribosomal protein uS2 family
RD16_RS07115	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RD16_RS07120	COG0528	UMP kinase activity
RD16_RS07125	COG0233	cytoplasmic translational termination
RD16_RS07130	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RD16_RS07140	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RD16_RS07145	COG0750	zinc metalloprotease
RD16_RS07150	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RD16_RS07155	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
RD16_RS07160	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RD16_RS07165	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RD16_RS07175	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RD16_RS07180	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RD16_RS07185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RD16_RS07190	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
RD16_RS07200	COG0519	Catalyzes the synthesis of GMP from XMP
RD16_RS07200	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RD16_RS07215	COG0330	HflC and HflK could
RD16_RS07220	COG3706	GGDEF domain
RD16_RS07225	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RD16_RS07230	COG2867	negative regulation of translational initiation
RD16_RS07240	COG1960	acyl-CoA dehydrogenase activity
RD16_RS07245	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
RD16_RS07275	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RD16_RS07280	COG0505	Belongs to the CarA family
RD16_RS07285	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RD16_RS07295	COG0406	alpha-ribazole phosphatase activity
RD16_RS07305	COG3842	ATPase activity
RD16_RS07325	COG5001	Diguanylate cyclase
RD16_RS07330	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RD16_RS07340	COG1763	Mo-molybdopterin cofactor biosynthetic process
RD16_RS07345	COG0303	'Molybdopterin
RD16_RS07350	COG0746	molybdenum cofactor guanylyltransferase activity
RD16_RS07355	COG0489	protein tyrosine kinase activity
RD16_RS07385	COG0243	molybdopterin cofactor binding
RD16_RS07385	COG3383	formate dehydrogenase (NAD+) activity
RD16_RS07390	COG0437	4 iron, 4 sulfur cluster binding
RD16_RS07420	COG1122	ATPase activity
RD16_RS07430	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RD16_RS07435	COG0066	3-isopropylmalate dehydratase activity
RD16_RS07440	COG0473	3-isopropylmalate dehydrogenase activity
RD16_RS07445	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RD16_RS07455	COG0101	tRNA pseudouridine synthase activity
RD16_RS07460	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD16_RS07475	COG0135	phosphoribosylanthranilate isomerase activity
RD16_RS07500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RD16_RS07510	COG2197	response regulator
RD16_RS07515	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RD16_RS07520	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RD16_RS07525	COG0189	ligase activity
RD16_RS07535	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RD16_RS07540	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RD16_RS07550	COG2423	ornithine cyclodeaminase activity
RD16_RS07560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD16_RS07565	COG0765	amino acid transport
RD16_RS07570	COG0765	amino acid transport
RD16_RS07575	COG1126	abc transporter atp-binding protein
RD16_RS07630	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RD16_RS07640	COG2944	sequence-specific DNA binding
RD16_RS07645	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
RD16_RS07650	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RD16_RS07655	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RD16_RS07660	COG0009	L-threonylcarbamoyladenylate synthase
RD16_RS07665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD16_RS07670	COG1414	Transcriptional regulator
RD16_RS07685	COG0765	amino acid transport
RD16_RS07690	COG1126	abc transporter atp-binding protein
RD16_RS07695	COG0028	Belongs to the TPP enzyme family
RD16_RS07710	COG0028	Belongs to the TPP enzyme family
RD16_RS07715	COG0583	DNA-binding transcription factor activity
RD16_RS07720	COG4974	Belongs to the 'phage' integrase family
RD16_RS07725	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RD16_RS07730	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
RD16_RS07745	COG1686	Belongs to the peptidase S11 family
RD16_RS07755	COG2814	Major facilitator Superfamily
RD16_RS07765	COG1074	ATP-dependent DNA helicase activity
RD16_RS07775	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RD16_RS07780	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RD16_RS07785	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RD16_RS07805	COG2321	neutral zinc metallopeptidase
RD16_RS07810	COG0009	L-threonylcarbamoyladenylate synthase
RD16_RS07850	COG3360	Dodecin
RD16_RS07855	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RD16_RS07860	COG2850	peptidyl-arginine hydroxylation
RD16_RS07865	COG3539	Fimbrial protein
RD16_RS07870	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
RD16_RS07875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RD16_RS07880	COG1994	Peptidase M50
RD16_RS07890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD16_RS07895	COG0765	amino acid transport
RD16_RS07900	COG1126	abc transporter atp-binding protein
RD16_RS07905	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RD16_RS07910	COG1758	RNA polymerase activity
RD16_RS07915	COG0194	GDP metabolic process
RD16_RS07920	COG3258	Cytochrome c
RD16_RS07925	COG2863	cytochrome
RD16_RS07930	COG1028	Short-chain dehydrogenase reductase Sdr
RD16_RS07935	COG0791	NLP P60 protein
RD16_RS07940	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RD16_RS07960	COG1561	YicC-like family, N-terminal region
RD16_RS07965	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RD16_RS07980	COG2199	diguanylate cyclase activity
RD16_RS07980	COG2200	EAL domain
RD16_RS07985	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RD16_RS07995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RD16_RS08000	COG0174	glutamine synthetase
RD16_RS08010	COG2204	response regulator
RD16_RS08015	COG0583	DNA-binding transcription factor activity
RD16_RS08020	COG1741	Belongs to the pirin family
RD16_RS08025	COG1741	Belongs to the pirin family
RD16_RS08035	COG3842	ATPase activity
RD16_RS08040	COG1178	ABC-type Fe3 transport system permease component
RD16_RS08045	COG1840	ABC-type Fe3 transport system, periplasmic component
RD16_RS08055	COG0583	DNA-binding transcription factor activity
RD16_RS08065	COG0656	L-ascorbic acid biosynthetic process
RD16_RS08080	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RD16_RS08085	COG0583	DNA-binding transcription factor activity
RD16_RS08100	COG0783	Belongs to the Dps family
RD16_RS08135	COG0438	transferase activity, transferring glycosyl groups
RD16_RS08150	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
RD16_RS08180	COG3119	arylsulfatase activity
RD16_RS08210	COG0714	Associated with various cellular activities
RD16_RS08230	COG1028	Short-chain dehydrogenase reductase Sdr
RD16_RS08235	COG0861	Integral membrane protein TerC family
RD16_RS08280	COG0300	oxidoreductase activity
RD16_RS08300	COG2197	response regulator
RD16_RS08310	COG2944	sequence-specific DNA binding
RD16_RS08315	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
RD16_RS08320	COG0625	glutathione transferase activity
RD16_RS08350	COG0179	Fumarylacetoacetate (FAA) hydrolase
RD16_RS08355	COG1028	Short-chain dehydrogenase reductase Sdr
RD16_RS08400	COG0431	NADPH-dependent FMN reductase
RD16_RS08430	COG1028	Short-chain dehydrogenase reductase Sdr
RD16_RS08435	COG0583	DNA-binding transcription factor activity
RD16_RS08450	COG3181	Tripartite tricarboxylate transporter family receptor
RD16_RS08455	COG2111	Na H antiporter
RD16_RS08455	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RD16_RS08460	COG1006	Multisubunit Na H antiporter MnhC subunit
RD16_RS08465	COG0651	ATP synthesis coupled electron transport
RD16_RS08470	COG1863	multisubunit Na H antiporter MnhE subunit
RD16_RS08475	COG2212	antiporter activity
RD16_RS08500	COG0590	tRNA wobble adenosine to inosine editing
RD16_RS08505	COG1619	proteins homologs of microcin C7 resistance protein MccF
RD16_RS08510	COG1024	Enoyl-CoA hydratase
RD16_RS08525	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD16_RS08530	COG0488	(ABC) transporter
RD16_RS08565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RD16_RS08575	COG2252	PERMEase
RD16_RS08580	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RD16_RS08590	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RD16_RS08595	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
RD16_RS08625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RD16_RS08630	COG0789	Transcriptional regulator
RD16_RS08640	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RD16_RS08640	COG0678	peroxiredoxin activity
RD16_RS08650	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
RD16_RS08655	COG0584	glycerophosphoryl diester phosphodiesterase
RD16_RS08660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RD16_RS08670	COG4181	ATPase activity
RD16_RS08680	COG2823	Periplasmic or secreted lipoprotein
RD16_RS08690	COG3237	CsbD-like
RD16_RS08695	COG1181	Belongs to the D-alanine--D-alanine ligase family
RD16_RS08695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RD16_RS08700	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RD16_RS08700	COG0189	ligase activity
RD16_RS08720	COG2833	Protein of unknown function (DUF455)
RD16_RS08725	COG2951	lytic endotransglycosylase activity
RD16_RS08740	COG1522	sequence-specific DNA binding
RD16_RS08750	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RD16_RS08755	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RD16_RS08760	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RD16_RS08765	COG0196	riboflavin kinase activity
RD16_RS08770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RD16_RS08770	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RD16_RS08795	COG0210	DNA helicase
RD16_RS08800	COG4771	TonB-dependent receptor
RD16_RS08805	COG0488	(ABC) transporter
RD16_RS08810	COG2890	protein-(glutamine-N5) methyltransferase activity
RD16_RS08815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RD16_RS08820	COG2171	N-acyltransferase activity
RD16_RS08855	COG1278	Cold shock
RD16_RS08865	COG1278	Cold shock
RD16_RS08875	COG0544	peptidyl-prolyl cis-trans isomerase activity
RD16_RS08880	COG0740	serine-type endopeptidase activity
RD16_RS08885	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RD16_RS08890	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RD16_RS08895	COG0583	DNA-binding transcription factor activity
RD16_RS08900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD16_RS08915	COG1024	Enoyl-CoA hydratase
RD16_RS08925	COG0183	Belongs to the thiolase family
RD16_RS08930	COG1028	Short-chain dehydrogenase reductase Sdr
RD16_RS08935	COG1960	acyl-CoA dehydrogenase activity
RD16_RS08950	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RD16_RS08975	COG3468	outer membrane autotransporter barrel domain protein
RD16_RS08980	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RD16_RS08990	COG0556	nucleotide-excision repair
RD16_RS08995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RD16_RS09005	COG1104	cysteine desulfurase activity
RD16_RS09010	COG0822	iron-sulfur transferase activity
RD16_RS09015	COG0316	Belongs to the HesB IscA family
RD16_RS09020	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RD16_RS09025	COG0443	Heat shock 70 kDa protein
RD16_RS09030	COG0633	Ferredoxin
RD16_RS09050	COG1024	Enoyl-CoA hydratase
RD16_RS09070	COG3395	kinase activity
RD16_RS09075	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RD16_RS09090	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
RD16_RS09100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD16_RS09125	COG0747	negative chemotaxis
RD16_RS09130	COG0601	transmembrane transport
RD16_RS09135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD16_RS09140	COG4172	Belongs to the ABC transporter superfamily
RD16_RS09145	COG0154	amidase activity
RD16_RS09190	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RD16_RS09195	COG0425	Belongs to the sulfur carrier protein TusA family
RD16_RS09205	COG0228	four-way junction DNA binding
RD16_RS09210	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RD16_RS09215	COG0336	Belongs to the RNA methyltransferase TrmD family
RD16_RS09220	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RD16_RS09245	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RD16_RS09250	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RD16_RS09255	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RD16_RS09260	COG0084	hydrolase, TatD family'
RD16_RS09275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD16_RS09285	COG1126	abc transporter atp-binding protein
RD16_RS09290	COG0010	Belongs to the arginase family
RD16_RS09295	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RD16_RS09300	COG1012	belongs to the aldehyde dehydrogenase family
RD16_RS09310	COG0028	Belongs to the TPP enzyme family
RD16_RS09320	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD16_RS09320	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD16_RS09330	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD16_RS09345	COG3189	MarR family transcriptional regulator
RD16_RS09370	COG4336	lyase activity
RD16_RS09380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD16_RS09380	COG2205	protein histidine kinase activity
RD16_RS09385	COG2197	response regulator
RD16_RS09390	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
RD16_RS09390	COG3210	domain, Protein
RD16_RS09390	COG3064	Membrane
RD16_RS09400	COG3121	Chaperone
RD16_RS09405	COG3188	usher protein
RD16_RS09410	COG3539	Fimbrial protein
RD16_RS09415	COG2831	hemolysin activation secretion protein
RD16_RS09430	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD16_RS09455	COG0583	DNA-binding transcription factor activity
RD16_RS09480	COG0668	transmembrane transport
RD16_RS09500	COG0483	inositol monophosphate 1-phosphatase activity
RD16_RS09505	COG1253	flavin adenine dinucleotide binding
RD16_RS09510	COG1968	undecaprenyl-diphosphatase activity
RD16_RS09515	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RD16_RS09530	COG0215	cysteine-tRNA ligase activity
RD16_RS09540	COG0825	malonyl-CoA metabolic process
RD16_RS09550	COG0037	tRNA processing
RD16_RS09555	COG0527	aspartate kinase activity
RD16_RS09580	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD16_RS09585	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD16_RS09585	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD16_RS09600	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RD16_RS09605	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
RD16_RS09610	COG1028	Short-chain dehydrogenase reductase Sdr
RD16_RS09620	COG0583	DNA-binding transcription factor activity
RD16_RS09650	COG3842	ATPase activity
RD16_RS09660	COG1902	pentaerythritol trinitrate reductase activity
RD16_RS09660	COG0446	pyridine nucleotide-disulphide oxidoreductase
RD16_RS09665	COG1414	Transcriptional regulator
RD16_RS09670	COG1832	CoA-binding protein
RD16_RS09680	COG0251	oxidation-reduction process
RD16_RS09705	COG1902	pentaerythritol trinitrate reductase activity
RD16_RS09715	COG1215	transferase activity, transferring glycosyl groups
RD16_RS09720	COG0726	polysaccharide deacetylase
RD16_RS09720	COG1649	PFAM Uncharacterised BCR, COG1649
RD16_RS09740	COG1846	Transcriptional regulator
RD16_RS09770	COG2010	Cytochrome c
RD16_RS09770	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RD16_RS09775	COG2080	2 iron, 2 sulfur cluster binding
RD16_RS09780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RD16_RS09785	COG3473	Maleate cis-trans isomerase
RD16_RS09790	COG0596	Alpha beta hydrolase
RD16_RS09795	COG2309	aminopeptidase activity
RD16_RS09800	COG1335	isochorismatase
RD16_RS09815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RD16_RS09815	COG1017	nitric oxide dioxygenase activity
RD16_RS09830	COG3181	Tripartite tricarboxylate transporter family receptor
RD16_RS09855	COG0166	Belongs to the GPI family
RD16_RS09860	COG1045	serine acetyltransferase
RD16_RS09870	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RD16_RS09875	COG0483	inositol monophosphate 1-phosphatase activity
RD16_RS09880	COG1012	belongs to the aldehyde dehydrogenase family
RD16_RS09885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RD16_RS09900	COG0210	DNA helicase
RD16_RS09905	COG0598	Magnesium transport protein CorA
RD16_RS09915	COG0747	negative chemotaxis
RD16_RS09920	COG0601	transmembrane transport
RD16_RS09925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD16_RS09930	COG4172	Belongs to the ABC transporter superfamily
RD16_RS09935	COG1846	Transcriptional regulator
RD16_RS09980	COG4964	Belongs to the GSP D family
RD16_RS10020	COG2204	response regulator
RD16_RS10035	COG1595	DNA-templated transcription, initiation
RD16_RS10045	COG3474	cytochrome
RD16_RS10050	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RD16_RS10065	COG3384	dioxygenase
RD16_RS10070	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RD16_RS10095	COG2885	chlorophyll binding
RD16_RS10130	COG0697	spore germination
RD16_RS10135	COG0730	response to heat
RD16_RS10150	COG0583	DNA-binding transcription factor activity
RD16_RS10155	COG0427	acetyl-CoA hydrolase
RD16_RS10210	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD16_RS10215	COG0154	amidase activity
RD16_RS10225	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RD16_RS10240	COG0495	leucyl-tRNA aminoacylation
RD16_RS10245	COG2814	Major facilitator Superfamily
RD16_RS10270	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RD16_RS10275	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RD16_RS10280	COG2814	Major facilitator Superfamily
RD16_RS10285	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RD16_RS10300	COG4176	ABC-type proline glycine betaine transport system permease component
RD16_RS10310	COG1942	4-Oxalocrotonate Tautomerase
RD16_RS10315	COG0183	Belongs to the thiolase family
RD16_RS10325	COG1802	Transcriptional regulator
RD16_RS10335	COG1024	Enoyl-CoA hydratase
RD16_RS10350	COG2032	superoxide dismutase activity
RD16_RS10365	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RD16_RS10390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RD16_RS10395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RD16_RS10405	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
RD16_RS10410	COG0736	holo-[acyl-carrier-protein] synthase activity
RD16_RS10415	COG1472	Belongs to the glycosyl hydrolase 3 family
RD16_RS10420	COG0322	excinuclease ABC activity
RD16_RS10425	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RD16_RS10440	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RD16_RS10440	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RD16_RS10445	COG2224	Isocitrate lyase
RD16_RS10465	COG0559	Belongs to the binding-protein-dependent transport system permease family
RD16_RS10475	COG4638	Rieske (2fe-2S)
RD16_RS10485	COG1024	Enoyl-CoA hydratase
RD16_RS10495	COG0633	Ferredoxin
RD16_RS10500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD16_RS10515	COG0183	Belongs to the thiolase family
RD16_RS10525	COG4692	amylo-alpha-1,6-glucosidase activity
RD16_RS10530	COG0583	DNA-binding transcription factor activity
RD16_RS10555	COG2346	COG2346, Truncated hemoglobins
RD16_RS10680	COG2207	Transcriptional regulator
RD16_RS10730	COG1132	(ABC) transporter
RD16_RS10755	COG0659	secondary active sulfate transmembrane transporter activity
RD16_RS10785	COG2169	Transcriptional regulator
RD16_RS10790	COG5507	3-demethylubiquinone-9 3-methyltransferase
RD16_RS10795	COG0384	phenazine biosynthesis protein PhzF
RD16_RS10800	COG0583	DNA-binding transcription factor activity
RD16_RS10805	COG2733	membrane
RD16_RS10820	COG1012	belongs to the aldehyde dehydrogenase family
RD16_RS10825	COG3284	Transcriptional regulator
RD16_RS10835	COG1346	cytolysis
RD16_RS10840	COG1380	Effector of murein hydrolase LrgA
RD16_RS10845	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RD16_RS10845	COG4106	trans-aconitate 2-methyltransferase activity
RD16_RS10855	COG0156	8-amino-7-oxononanoate synthase activity
RD16_RS10925	COG1131	(ABC) transporter
RD16_RS10930	COG0842	Transport permease protein
RD16_RS10935	COG0628	permease
RD16_RS10960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RD16_RS10970	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RD16_RS10975	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
RD16_RS10980	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RD16_RS10985	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
RD16_RS10990	COG0330	HflC and HflK could
RD16_RS10995	COG0330	HflC and HflK could
RD16_RS11000	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RD16_RS11005	COG1923	regulation of RNA biosynthetic process
RD16_RS11010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RD16_RS11015	COG1160	GTP binding
RD16_RS11020	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RD16_RS11025	COG2976	Protein conserved in bacteria
RD16_RS11030	COG0124	histidyl-tRNA synthetase
RD16_RS11035	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RD16_RS11045	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RD16_RS11050	COG0105	UTP biosynthetic process
RD16_RS11055	COG0525	valine-tRNA ligase activity
RD16_RS11070	COG0642	Histidine kinase
RD16_RS11085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD16_RS11090	COG1959	2 iron, 2 sulfur cluster binding
RD16_RS11095	COG1017	nitric oxide dioxygenase activity
RD16_RS11095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RD16_RS11125	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RD16_RS11130	COG2358	TRAP transporter, solute receptor (TAXI family
RD16_RS11160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RD16_RS11165	COG1366	Belongs to the anti-sigma-factor antagonist family
RD16_RS11170	COG2172	sigma factor antagonist activity
RD16_RS11175	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RD16_RS11185	COG2208	phosphoserine phosphatase activity
RD16_RS11185	COG2770	Histidine kinase
RD16_RS11210	COG1595	DNA-templated transcription, initiation
RD16_RS11225	COG4792	protein secretion
RD16_RS11230	COG4791	protein targeting
RD16_RS11235	COG4794	Type iii secretion
RD16_RS11240	COG4790	Type iii secretion
RD16_RS11275	COG4669	(LipO)protein
RD16_RS11340	COG4789	Type iii secretion
RD16_RS11370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RD16_RS11375	COG0840	transmembrane signaling receptor activity
RD16_RS11380	COG2233	PERMEase
RD16_RS11400	COG0492	ferredoxin-NADP+ reductase activity
RD16_RS11405	COG1840	ABC-type Fe3 transport system, periplasmic component
RD16_RS11410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RD16_RS11415	COG1178	ABC-type Fe3 transport system permease component
RD16_RS11420	COG3842	ATPase activity
RD16_RS11425	COG0583	DNA-binding transcription factor activity
RD16_RS11445	COG0501	Belongs to the peptidase M48B family
RD16_RS11455	COG0697	spore germination
RD16_RS11465	COG1846	Transcriptional regulator
RD16_RS11475	COG1566	PFAM secretion protein HlyD family protein
RD16_RS11480	COG2814	Major facilitator Superfamily
RD16_RS11485	COG0473	3-isopropylmalate dehydrogenase activity
RD16_RS11495	COG0747	negative chemotaxis
RD16_RS11505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD16_RS11520	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RD16_RS11545	COG1012	belongs to the aldehyde dehydrogenase family
RD16_RS11555	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RD16_RS11560	COG1115	amino acid carrier protein
RD16_RS11565	COG0433	COG0433 Predicted ATPase
RD16_RS11570	COG0217	transcriptional regulatory protein
RD16_RS11575	COG0151	Belongs to the GarS family
RD16_RS11580	COG0408	coproporphyrinogen oxidase activity
RD16_RS11585	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RD16_RS11590	COG0799	negative regulation of ribosome biogenesis
RD16_RS11595	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RD16_RS11600	COG0424	maF-like protein
RD16_RS11605	COG3468	outer membrane autotransporter barrel domain protein
RD16_RS11645	COG1530	ribonuclease E activity
RD16_RS11650	COG0077	Prephenate dehydratase
RD16_RS11665	COG1132	(ABC) transporter
RD16_RS11670	COG0859	PFAM glycosyl transferase family 9
RD16_RS11695	COG2194	sulfuric ester hydrolase activity
RD16_RS11700	COG0438	transferase activity, transferring glycosyl groups
RD16_RS11705	COG0463	Glycosyl transferase, family 2
RD16_RS11710	COG0726	polysaccharide deacetylase
RD16_RS11715	COG0438	transferase activity, transferring glycosyl groups
RD16_RS11730	COG1643	Atp-dependent helicase
RD16_RS11735	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RD16_RS11735	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RD16_RS11740	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
RD16_RS11750	COG0704	Plays a role in the regulation of phosphate uptake
RD16_RS11755	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
RD16_RS11760	COG1960	acyl-CoA dehydrogenase activity
RD16_RS11785	COG1177	transmembrane transport
RD16_RS11790	COG1176	ABC-type spermidine putrescine transport system, permease component I
RD16_RS11795	COG3842	ATPase activity
RD16_RS11800	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RD16_RS11815	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
RD16_RS11820	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD16_RS11830	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD16_RS11830	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD16_RS11850	COG0372	Belongs to the citrate synthase family
RD16_RS11855	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
RD16_RS11860	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RD16_RS11865	COG1053	succinate dehydrogenase
RD16_RS11870	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
RD16_RS11875	COG2009	succinate dehydrogenase
RD16_RS11880	COG2188	Transcriptional regulator
RD16_RS11885	COG0039	L-malate dehydrogenase activity
RD16_RS11915	COG1981	membrane
RD16_RS11940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RD16_RS11950	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
RD16_RS11980	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
RD16_RS11985	COG0148	phosphopyruvate hydratase activity
RD16_RS11995	COG2877	3-deoxy-8-phosphooctulonate synthase activity
RD16_RS12000	COG0504	CTP synthase activity
RD16_RS12025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD16_RS12035	COG0747	negative chemotaxis
RD16_RS12040	COG4172	Belongs to the ABC transporter superfamily
RD16_RS12045	COG1446	asparaginase
RD16_RS12075	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RD16_RS12090	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
RD16_RS12095	COG0697	spore germination
RD16_RS12100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RD16_RS12110	COG3193	protein, possibly involved in utilization of glycolate and propanediol
RD16_RS12115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RD16_RS12120	COG0791	NLP P60 protein
RD16_RS12135	COG0583	DNA-binding transcription factor activity
RD16_RS12150	COG0583	DNA-binding transcription factor activity
RD16_RS12160	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RD16_RS12175	COG0670	Belongs to the BI1 family
RD16_RS12180	COG3181	Tripartite tricarboxylate transporter family receptor
RD16_RS12195	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RD16_RS12205	COG1381	Involved in DNA repair and RecF pathway recombination
RD16_RS12210	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RD16_RS12215	COG0571	ribonuclease III activity
RD16_RS12220	COG0681	Belongs to the peptidase S26 family
RD16_RS12225	COG0481	GTPase activity
RD16_RS12230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RD16_RS12255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RD16_RS12260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RD16_RS12275	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RD16_RS12280	COG0416	fatty acid biosynthetic process
RD16_RS12285	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RD16_RS12290	COG1399	metal-binding, possibly nucleic acid-binding protein
RD16_RS12295	COG0424	maF-like protein
RD16_RS12305	COG3023	N-Acetylmuramoyl-L-alanine amidase
RD16_RS12310	COG1289	transmembrane transporter activity
RD16_RS12320	COG3022	response to hydroperoxide
RD16_RS12330	COG1028	Short-chain dehydrogenase reductase Sdr
RD16_RS12345	COG3486	L-lysine 6-monooxygenase (NADPH) activity
RD16_RS12375	COG2814	Major facilitator Superfamily
RD16_RS12395	COG3706	GGDEF domain
RD16_RS12420	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RD16_RS12425	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RD16_RS12430	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
RD16_RS12435	COG1674	ftsk spoiiie
RD16_RS12440	COG0492	ferredoxin-NADP+ reductase activity
RD16_RS12445	COG1193	negative regulation of DNA recombination
RD16_RS12460	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RD16_RS12470	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
RD16_RS12475	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
RD16_RS12480	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
RD16_RS12485	COG2205	protein histidine kinase activity
RD16_RS12490	COG0745	RESPONSE REGULATOR receiver
RD16_RS12535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RD16_RS12555	COG0612	Peptidase, M16
RD16_RS12560	COG0484	heat shock protein binding
RD16_RS12565	COG0443	Heat shock 70 kDa protein
RD16_RS12575	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RD16_RS12585	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RD16_RS12590	COG1420	regulation of RNA biosynthetic process
RD16_RS12595	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RD16_RS12600	COG0497	DNA recombination
RD16_RS12605	COG0735	belongs to the Fur family
RD16_RS12610	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RD16_RS12615	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RD16_RS12620	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RD16_RS12655	COG0446	pyridine nucleotide-disulphide oxidoreductase
RD16_RS12655	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RD16_RS12660	COG4311	Sarcosine oxidase, delta subunit
RD16_RS12665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD16_RS12675	COG0583	DNA-binding transcription factor activity
RD16_RS12685	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RD16_RS12715	COG4964	Belongs to the GSP D family
RD16_RS12775	COG0181	hydroxymethylbilane synthase activity
RD16_RS12780	COG0861	Integral membrane protein TerC family
RD16_RS12785	COG0861	Integral membrane protein TerC family
RD16_RS12790	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RD16_RS12795	COG0045	succinate-CoA ligase (ADP-forming) activity
RD16_RS12805	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
RD16_RS12815	COG2137	regulation of response to DNA damage stimulus
RD16_RS12820	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RD16_RS12840	COG1024	Enoyl-CoA hydratase
RD16_RS12840	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD16_RS12845	COG3842	ATPase activity
RD16_RS12860	COG1028	Short-chain dehydrogenase reductase Sdr
RD16_RS12880	COG0583	DNA-binding transcription factor activity
RD16_RS12885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD16_RS12895	COG2974	May be involved in recombination
RD16_RS12900	COG0540	Belongs to the ATCase OTCase family
RD16_RS12970	COG0776	regulation of translation
RD16_RS12975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RD16_RS12975	COG0072	phenylalanine-tRNA ligase activity
RD16_RS12980	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RD16_RS12985	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RD16_RS12990	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RD16_RS13000	COG0756	dUTP diphosphatase activity
RD16_RS13010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RD16_RS13025	COG0500	methyltransferase
RD16_RS13035	COG0586	Pfam SNARE associated Golgi protein
RD16_RS13060	COG1609	Transcriptional regulator
RD16_RS13065	COG4172	Belongs to the ABC transporter superfamily
RD16_RS13070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD16_RS13075	COG0601	transmembrane transport
RD16_RS13080	COG0747	negative chemotaxis
RD16_RS13095	COG1280	lysine exporter protein (LysE YggA)
RD16_RS13110	COG2814	Major facilitator Superfamily
RD16_RS13140	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
RD16_RS13155	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
RD16_RS13180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD16_RS13185	COG1116	anion transmembrane transporter activity
RD16_RS13195	COG1228	amidohydrolase
RD16_RS13210	COG0477	Major facilitator Superfamily
RD16_RS13220	COG3550	peptidyl-serine autophosphorylation
RD16_RS13230	COG0519	Catalyzes the synthesis of GMP from XMP
RD16_RS13230	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RD16_RS13255	COG2197	response regulator
RD16_RS13280	COG0420	3'-5' exonuclease activity
RD16_RS13285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD16_RS13315	COG0395	ABC-type sugar transport system, permease component
RD16_RS13325	COG3842	ATPase activity
RD16_RS13355	COG3181	Tripartite tricarboxylate transporter family receptor
RD16_RS13390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RD16_RS13415	COG0602	queuosine metabolic process
RD16_RS13420	COG0720	synthase
RD16_RS13425	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD16_RS13430	COG0235	Class ii aldolase
RD16_RS13455	COG3064	Membrane
RD16_RS13455	COG3210	domain, Protein
RD16_RS13455	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
RD16_RS13460	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RD16_RS13460	COG0047	phosphoribosylformylglycinamidine synthase activity
RD16_RS13465	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD16_RS13470	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD16_RS13470	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD16_RS13475	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD16_RS13495	COG3539	Fimbrial protein
RD16_RS13505	COG2050	protein possibly involved in aromatic compounds catabolism
RD16_RS13510	COG1024	Enoyl-CoA hydratase
RD16_RS13515	COG1012	belongs to the aldehyde dehydrogenase family
RD16_RS13525	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RD16_RS13530	COG2151	metal-sulfur cluster biosynthetic enzyme
RD16_RS13535	COG3396	Phenylacetate-CoA oxygenase
RD16_RS13540	COG3460	Phenylacetate-CoA oxygenase
RD16_RS13545	COG3396	Phenylacetate-CoA oxygenase
RD16_RS13550	COG3327	negative regulation of DNA-templated transcription, initiation
RD16_RS13560	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
RD16_RS13565	COG0501	Belongs to the peptidase M48B family
RD16_RS13570	COG1162	GTPase activity
RD16_RS13575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD16_RS13580	COG0601	transmembrane transport
RD16_RS13585	COG0747	negative chemotaxis
RD16_RS13630	COG0668	transmembrane transport
RD16_RS13635	COG0165	Argininosuccinate lyase
RD16_RS13655	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RD16_RS13660	COG0303	'Molybdopterin
RD16_RS13665	COG0521	Mo-molybdopterin cofactor biosynthetic process
RD16_RS13680	COG0315	cyclic pyranopterin monophosphate synthase activity
RD16_RS13690	COG0412	Dienelactone hydrolase
RD16_RS13700	COG0678	peroxiredoxin activity
RD16_RS13710	COG0697	spore germination
RD16_RS13715	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RD16_RS13740	COG0789	Transcriptional regulator
RD16_RS13755	COG1028	Short-chain dehydrogenase reductase Sdr
RD16_RS13765	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RD16_RS13770	COG1845	cytochrome c oxidase, subunit III
RD16_RS13775	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RD16_RS13785	COG0477	Major facilitator Superfamily
RD16_RS13815	COG3468	outer membrane autotransporter barrel domain protein
RD16_RS13825	COG1309	transcriptional regulator
RD16_RS13830	COG2271	Major facilitator Superfamily
RD16_RS13865	COG0506	proline dehydrogenase activity
RD16_RS13865	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RD16_RS13865	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RD16_RS13875	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RD16_RS13875	COG3008	intermembrane lipid transfer
RD16_RS13880	COG2995	paraquat-inducible protein a
RD16_RS13885	COG0542	response to heat
RD16_RS13890	COG4953	penicillin-binding protein 1C
RD16_RS13900	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RD16_RS13905	COG1278	Cold shock
RD16_RS13915	COG0183	Belongs to the thiolase family
RD16_RS13920	COG0038	chloride channel
RD16_RS13925	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RD16_RS13930	COG1570	exodeoxyribonuclease VII activity
RD16_RS13940	COG0811	peptide transport
RD16_RS13945	COG0848	biopolymer transport protein
RD16_RS13950	COG1663	tetraacyldisaccharide 4'-kinase activity
RD16_RS13955	COG2835	tetraacyldisaccharide 4'-kinase activity
RD16_RS13960	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
RD16_RS13965	COG0563	adenylate kinase activity
RD16_RS13975	COG0728	peptidoglycan biosynthetic process
RD16_RS13985	COG0268	Binds directly to 16S ribosomal RNA
RD16_RS14015	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RD16_RS14040	COG0436	Aminotransferase
RD16_RS14045	COG3737	Protein of unknown function (DUF498/DUF598)
RD16_RS14050	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RD16_RS14055	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
RD16_RS14060	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RD16_RS14070	COG0305	Participates in initiation and elongation during chromosome replication
RD16_RS14080	COG0359	binds to the 23S rRNA
RD16_RS14085	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RD16_RS14090	COG2965	DNA replication, synthesis of RNA primer
RD16_RS14095	COG0360	Binds together with S18 to 16S ribosomal RNA
RD16_RS14100	COG1469	GTP cyclohydrolase I activity
RD16_RS14105	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RD16_RS14110	COG0142	geranyltranstransferase activity
RD16_RS14115	COG1722	exodeoxyribonuclease VII activity
RD16_RS14125	COG3181	Tripartite tricarboxylate transporter family receptor
RD16_RS14145	COG2239	Acts as a magnesium transporter
RD16_RS14155	COG2855	membrane
RD16_RS14165	COG1473	amidohydrolase
RD16_RS14170	COG0318	PFAM AMP-dependent synthetase and ligase
RD16_RS14190	COG1501	Belongs to the glycosyl hydrolase 31 family
RD16_RS14195	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RD16_RS14200	COG2011	ABC-type metal ion transport system permease component
RD16_RS14220	COG1454	alcohol dehydrogenase
RD16_RS14245	COG2186	Transcriptional regulator
RD16_RS14250	COG3181	Tripartite tricarboxylate transporter family receptor
RD16_RS14270	COG1175	transmembrane transport
RD16_RS14275	COG0395	ABC-type sugar transport system, permease component
RD16_RS14280	COG3842	ATPase activity
RD16_RS14285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RD16_RS14295	COG1653	transport
RD16_RS14315	COG2818	Glycosylase
RD16_RS14320	COG2982	Protein involved in outer membrane biogenesis
RD16_RS14325	COG1309	transcriptional regulator
RD16_RS14330	COG1028	Short-chain dehydrogenase reductase Sdr
RD16_RS14370	COG0583	DNA-binding transcription factor activity
RD16_RS14375	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
RD16_RS14380	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RD16_RS14395	COG1028	Short-chain dehydrogenase reductase Sdr
RD16_RS14400	COG0477	Major facilitator Superfamily
RD16_RS14410	COG0583	DNA-binding transcription factor activity
RD16_RS14415	COG1448	Aminotransferase
RD16_RS14420	COG1418	mRNA catabolic process
RD16_RS14445	COG1063	alcohol dehydrogenase
RD16_RS14465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD16_RS14475	COG0318	PFAM AMP-dependent synthetase and ligase
RD16_RS14485	COG1522	sequence-specific DNA binding
RD16_RS14490	COG3181	Tripartite tricarboxylate transporter family receptor
RD16_RS14495	COG0307	riboflavin synthase, alpha
RD16_RS14500	COG0154	amidase activity
RD16_RS14520	COG2807	transmembrane transport
RD16_RS14525	COG0590	tRNA wobble adenosine to inosine editing
RD16_RS14535	COG0583	DNA-binding transcription factor activity
RD16_RS14570	COG3909	cytochrome
RD16_RS14575	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RD16_RS14580	COG0625	glutathione transferase activity
RD16_RS14585	COG0730	response to heat
RD16_RS14590	COG0482	sulfurtransferase activity
RD16_RS14595	COG0583	DNA-binding transcription factor activity
RD16_RS14630	COG2819	hydrolase of the alpha beta superfamily
RD16_RS14635	COG0247	lactate metabolic process
RD16_RS14640	COG0277	FAD linked oxidase domain protein
RD16_RS14645	COG0277	FAD linked oxidase domain protein
RD16_RS14650	COG0277	FAD linked oxidase domain protein
RD16_RS14655	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
RD16_RS14655	COG3210	domain, Protein
RD16_RS14655	COG3064	Membrane
RD16_RS14655	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
RD16_RS14655	COG3210	domain, Protein
RD16_RS14655	COG3064	Membrane
RD16_RS14660	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RD16_RS14665	COG0312	modulator of DNA gyrase
RD16_RS14700	COG1666	GTP binding
RD16_RS14745	COG3220	belongs to the UPF0276 family
RD16_RS14765	COG0640	Transcriptional regulator
RD16_RS14770	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RD16_RS14775	COG1845	cytochrome c oxidase, subunit III
RD16_RS14780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RD16_RS14790	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
RD16_RS14825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD16_RS14830	COG0583	DNA-binding transcription factor activity
RD16_RS14860	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RD16_RS14860	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RD16_RS14875	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RD16_RS14880	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RD16_RS14890	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RD16_RS14905	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
RD16_RS14910	COG0316	Belongs to the HesB IscA family
RD16_RS14920	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RD16_RS14925	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RD16_RS14930	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RD16_RS14935	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD16_RS14940	COG0312	modulator of DNA gyrase
RD16_RS14945	COG3028	Belongs to the UPF0307 family
RD16_RS14960	COG1116	anion transmembrane transporter activity
RD16_RS14965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD16_RS14970	COG1335	isochorismatase
RD16_RS14975	COG0346	lactoylglutathione lyase activity
RD16_RS14980	COG0513	Belongs to the DEAD box helicase family
RD16_RS14985	COG3069	C4-dicarboxylate transmembrane transporter activity
RD16_RS14990	COG1802	Transcriptional regulator
RD16_RS15000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RD16_RS15000	COG1042	CoA-binding domain protein
RD16_RS15000	COG0045	succinate-CoA ligase (ADP-forming) activity
RD16_RS15005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RD16_RS15020	COG1522	sequence-specific DNA binding
RD16_RS15055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RD16_RS15060	COG1696	Membrane protein involved in D-alanine export
RD16_RS15085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RD16_RS15095	COG2264	protein methyltransferase activity
RD16_RS15100	COG0439	Biotin carboxylase
RD16_RS15105	COG0511	ligase activity, forming carbon-carbon bonds
RD16_RS15110	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RD16_RS15115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RD16_RS15120	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RD16_RS15125	COG3150	esterase
RD16_RS15130	COG0557	exoribonuclease II activity
RD16_RS15140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RD16_RS15165	COG1522	sequence-specific DNA binding
RD16_RS15170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD16_RS15175	COG1028	Short-chain dehydrogenase reductase Sdr
RD16_RS15195	COG0653	protein targeting
RD16_RS15200	COG0739	heme binding
RD16_RS15210	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
RD16_RS15215	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RD16_RS15225	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RD16_RS15230	COG1181	Belongs to the D-alanine--D-alanine ligase family
RD16_RS15235	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RD16_RS15240	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RD16_RS15250	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RD16_RS15255	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RD16_RS15260	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RD16_RS15270	COG3116	cell division
RD16_RS15275	COG0275	rRNA processing
RD16_RS15280	COG2001	Belongs to the MraZ family
RD16_RS15290	COG0488	(ABC) transporter
RD16_RS15295	COG0418	dihydroorotase activity
RD16_RS15300	COG1473	amidohydrolase
RD16_RS15350	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RD16_RS15355	COG4654	Cytochrome c, class I
RD16_RS15360	COG0129	dihydroxy-acid dehydratase activity
RD16_RS15365	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RD16_RS15415	COG2084	Dehydrogenase
RD16_RS15420	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RD16_RS15430	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RD16_RS15435	COG0513	Belongs to the DEAD box helicase family
RD16_RS15445	COG0617	tRNA 3'-terminal CCA addition
RD16_RS15460	COG0477	Major facilitator Superfamily
RD16_RS15470	COG0583	DNA-binding transcription factor activity
RD16_RS15485	COG1950	PFAM Membrane protein of
RD16_RS15490	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
RD16_RS15505	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RD16_RS15515	COG1560	Kdo2-lipid A biosynthetic process
RD16_RS15520	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RD16_RS15530	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
RD16_RS15540	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
RD16_RS15550	COG0803	Belongs to the bacterial solute-binding protein 9 family
RD16_RS15570	COG0735	belongs to the Fur family
RD16_RS15575	COG0523	cobalamin synthesis protein
RD16_RS15585	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
RD16_RS15590	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
RD16_RS15600	COG2096	Adenosyltransferase
RD16_RS15615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RD16_RS15620	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
RD16_RS15680	COG1280	lysine exporter protein (LysE YggA)
RD16_RS15695	COG0405	Gamma-glutamyltransferase
RD16_RS15705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD16_RS15745	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RD16_RS15765	COG0582	viral genome integration into host DNA
RD16_RS15770	COG0012	GTP binding
RD16_RS15780	COG0193	aminoacyl-tRNA hydrolase activity
RD16_RS15785	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RD16_RS15790	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RD16_RS15800	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RD16_RS15805	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
RD16_RS15815	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RD16_RS15840	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
RD16_RS15850	COG1368	sulfuric ester hydrolase activity
RD16_RS15855	COG0642	Histidine kinase
RD16_RS15860	COG0745	RESPONSE REGULATOR receiver
RD16_RS15865	COG0277	FAD linked oxidase domain protein
RD16_RS15880	COG0166	Belongs to the GPI family
RD16_RS15885	COG0438	transferase activity, transferring glycosyl groups
RD16_RS15890	COG0438	transferase activity, transferring glycosyl groups
RD16_RS15905	COG0438	transferase activity, transferring glycosyl groups
RD16_RS15920	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
RD16_RS15925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RD16_RS15930	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
RD16_RS15940	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RD16_RS15950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RD16_RS15955	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RD16_RS15965	COG0747	negative chemotaxis
RD16_RS15970	COG0601	transmembrane transport
RD16_RS15975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD16_RS15995	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RD16_RS16000	COG0830	nickel cation binding
RD16_RS16010	COG0804	urea catabolic process
RD16_RS16015	COG0832	Belongs to the urease beta subunit family
RD16_RS16025	COG0831	urea catabolic process
RD16_RS16030	COG0829	nickel cation binding
RD16_RS16040	COG0633	Ferredoxin
RD16_RS16055	COG2188	Transcriptional regulator
RD16_RS16080	COG2719	SpoVR family
RD16_RS16085	COG2718	Belongs to the UPF0229 family
RD16_RS16105	COG1028	Short-chain dehydrogenase reductase Sdr
RD16_RS16110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD16_RS16125	COG1960	acyl-CoA dehydrogenase activity
RD16_RS16170	COG0183	Belongs to the thiolase family
RD16_RS16175	COG2030	dehydratase
RD16_RS16220	COG0328	RNA-DNA hybrid ribonuclease activity
RD16_RS16225	COG2226	methyltransferase
RD16_RS16230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RD16_RS16235	COG1388	LysM domain
RD16_RS16235	COG0741	lytic transglycosylase activity
RD16_RS16255	COG2979	Protein of unknown function (DUF533)
RD16_RS16290	COG1271	oxidase subunit
RD16_RS16295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RD16_RS16300	COG0850	regulation of cytokinetic process
RD16_RS16305	COG2894	cell division
RD16_RS16310	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
RD16_RS16330	COG0488	(ABC) transporter
RD16_RS16340	COG0601	transmembrane transport
RD16_RS16350	COG1215	transferase activity, transferring glycosyl groups
RD16_RS16365	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RD16_RS16375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RD16_RS16395	COG0318	PFAM AMP-dependent synthetase and ligase
RD16_RS16400	COG2188	Transcriptional regulator
RD16_RS16405	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RD16_RS16410	COG2814	Major facilitator Superfamily
RD16_RS16420	COG0259	pyridoxamine-phosphate oxidase activity
RD16_RS16425	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RD16_RS16440	COG0583	DNA-binding transcription factor activity
RD16_RS16445	COG1960	acyl-CoA dehydrogenase activity
RD16_RS16470	COG0134	indole-3-glycerol-phosphate synthase activity
RD16_RS16475	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RD16_RS16480	COG0512	Glutamine amidotransferase of anthranilate synthase
RD16_RS16490	COG0546	phosphoglycolate phosphatase activity
RD16_RS16495	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RD16_RS16500	COG2967	ApaG domain
RD16_RS16505	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
RD16_RS16510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RD16_RS16515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RD16_RS16520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RD16_RS16530	COG0037	tRNA processing
RD16_RS16540	COG3634	alkyl hydroperoxide reductase activity
RD16_RS16545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RD16_RS16550	COG1024	Enoyl-CoA hydratase
RD16_RS16575	COG0356	it plays a direct role in the translocation of protons across the membrane
RD16_RS16585	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RD16_RS16590	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RD16_RS16595	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RD16_RS16600	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RD16_RS16605	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RD16_RS16610	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RD16_RS16620	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
RD16_RS16625	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RD16_RS16630	COG0210	DNA helicase
RD16_RS16640	COG2195	Cleaves the N-terminal amino acid of tripeptides
RD16_RS16650	COG4608	Belongs to the ABC transporter superfamily
RD16_RS16655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD16_RS16660	COG0601	transmembrane transport
RD16_RS16680	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RD16_RS16685	COG1024	Enoyl-CoA hydratase
RD16_RS16690	COG1024	Enoyl-CoA hydratase
RD16_RS16715	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD16_RS16745	COG2132	Multicopper oxidase
RD16_RS16755	COG1024	Enoyl-CoA hydratase
RD16_RS16755	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD16_RS16770	COG1414	Transcriptional regulator
RD16_RS16780	COG0154	amidase activity
RD16_RS16800	COG2154	pterin-4-alpha-carbinolamine dehydratase
RD16_RS16810	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RD16_RS16820	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RD16_RS16825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RD16_RS16830	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RD16_RS16835	COG1929	Belongs to the glycerate kinase type-1 family
RD16_RS16840	COG0469	pyruvate kinase activity
RD16_RS16845	COG0700	Nucleoside recognition
RD16_RS16875	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
RD16_RS16880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RD16_RS16895	COG0823	Involved in the tonB-independent uptake of proteins
RD16_RS16905	COG0848	biopolymer transport protein
RD16_RS16910	COG0811	peptide transport
RD16_RS16915	COG0824	Thioesterase
RD16_RS16920	COG0442	prolyl-tRNA aminoacylation
RD16_RS16925	COG0494	nUDIX hydrolase
RD16_RS16940	COG2135	peptidase activity
RD16_RS17005	COG1196	nuclear chromosome segregation
RD16_RS17155	COG0513	Belongs to the DEAD box helicase family
RD16_RS17185	COG0429	hydrolase of the alpha beta-hydrolase fold
RD16_RS17190	COG4783	chaperone-mediated protein folding
RD16_RS17205	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RD16_RS17235	COG0006	proline dipeptidase activity
RD16_RS17245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RD16_RS17265	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RD16_RS17270	COG0632	four-way junction helicase activity
RD16_RS17285	COG2255	four-way junction helicase activity
RD16_RS17290	COG0514	ATP-dependent DNA helicase (RecQ)
RD16_RS17305	COG0288	reversible hydration of carbon dioxide
RD16_RS17310	COG0154	amidase activity
RD16_RS17320	COG4211	Belongs to the binding-protein-dependent transport system permease family
RD16_RS17350	COG1464	Belongs to the NlpA lipoprotein family
RD16_RS17365	COG1546	Belongs to the CinA family
RD16_RS17365	COG1058	Belongs to the CinA family
RD16_RS17370	COG1414	Transcriptional regulator
RD16_RS17390	COG0167	dihydroorotate dehydrogenase activity
RD16_RS17395	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
RD16_RS17405	COG0583	DNA-binding transcription factor activity
RD16_RS17465	COG0280	phosphate acetyltransferase
RD16_RS17465	COG0281	malic enzyme
RD16_RS17475	COG0601	transmembrane transport
RD16_RS17480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD16_RS17485	COG4172	Belongs to the ABC transporter superfamily
RD16_RS17515	COG0640	Transcriptional regulator
RD16_RS17530	COG3135	benzoate transporter
RD16_RS17535	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RD16_RS17540	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RD16_RS17545	COG0742	ribosomal rna small subunit methyltransferase
RD16_RS17565	COG3639	organic phosphonate transmembrane transporter activity
RD16_RS17570	COG3639	organic phosphonate transmembrane transporter activity
RD16_RS17575	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RD16_RS17610	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RD16_RS17615	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RD16_RS17625	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RD16_RS17630	COG1058	Belongs to the CinA family
RD16_RS17630	COG1546	Belongs to the CinA family
RD16_RS17635	COG0284	orotidine-5'-phosphate decarboxylase activity
RD16_RS17640	COG1252	NADH dehydrogenase
RD16_RS17655	COG3468	outer membrane autotransporter barrel domain protein
RD16_RS17660	COG0459	protein refolding
RD16_RS17665	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RD16_RS17685	COG1053	succinate dehydrogenase
RD16_RS17695	COG0583	DNA-binding transcription factor activity
RD16_RS17700	COG1053	succinate dehydrogenase
RD16_RS17715	COG3706	GGDEF domain
RD16_RS17755	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RD16_RS17760	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
RD16_RS17770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RD16_RS17790	COG0069	glutamate synthase activity
RD16_RS17795	COG2391	methyltransferase activity
RD16_RS17800	COG0679	Auxin Efflux Carrier
RD16_RS17825	COG0557	exoribonuclease II activity
RD16_RS17830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RD16_RS17840	COG3128	pkhd-type hydroxylase
RD16_RS17845	COG0776	regulation of translation
RD16_RS17875	COG0642	Histidine kinase
RD16_RS17880	COG3158	transport of potassium into the cell
RD16_RS17885	COG0137	argininosuccinate synthase activity
RD16_RS17890	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RD16_RS17895	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RD16_RS17905	COG0583	DNA-binding transcription factor activity
RD16_RS17915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RD16_RS17935	COG2186	Transcriptional regulator
RD16_RS17945	COG2223	nitrite transmembrane transporter activity
RD16_RS17955	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RD16_RS17960	COG0450	alkyl hydroperoxide reductase
RD16_RS17980	COG1214	PFAM Peptidase M22, glycoprotease
RD16_RS17985	COG1573	uracil-dna glycosylase
RD16_RS17990	COG0477	Major facilitator Superfamily
RD16_RS17995	COG1196	nuclear chromosome segregation
RD16_RS18005	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RD16_RS18010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RD16_RS18025	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RD16_RS18030	COG1122	ATPase activity
RD16_RS18035	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
RD16_RS18040	COG1268	BioY protein
RD16_RS18060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RD16_RS18095	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RD16_RS18100	COG2878	Part of a membrane complex involved in electron transport
RD16_RS18115	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RD16_RS18120	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
RD16_RS18125	COG0251	oxidation-reduction process
RD16_RS18135	COG3228	Belongs to the MtfA family
RD16_RS18140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RD16_RS18150	COG0133	tryptophan synthase activity
RD16_RS18155	COG0159	tryptophan synthase activity
RD16_RS18160	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RD16_RS18165	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
RD16_RS18180	COG4206	TonB-dependent receptor
RD16_RS18185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RD16_RS18190	COG2022	thiamine diphosphate biosynthetic process
RD16_RS18195	COG0351	phosphomethylpyrimidine kinase
RD16_RS18200	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RD16_RS18215	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RD16_RS18225	COG0628	permease
RD16_RS18235	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RD16_RS18245	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RD16_RS18250	COG0049	tRNA binding
RD16_RS18255	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RD16_RS18260	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RD16_RS18265	COG0051	transcription antitermination factor activity, RNA binding
RD16_RS18270	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RD16_RS18275	COG0088	Forms part of the polypeptide exit tunnel
RD16_RS18280	COG0089	rRNA binding
RD16_RS18285	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RD16_RS18290	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RD16_RS18295	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RD16_RS18300	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RD16_RS18305	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RD16_RS18310	COG0255	Belongs to the universal ribosomal protein uL29 family
RD16_RS18315	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RD16_RS18335	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RD16_RS18340	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RD16_RS18345	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RD16_RS18350	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RD16_RS18355	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RD16_RS18360	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RD16_RS18365	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RD16_RS18370	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RD16_RS18375	COG1841	ribosomal large subunit assembly
RD16_RS18380	COG0200	Binds to the 23S rRNA
RD16_RS18385	COG0201	protein transport
RD16_RS18390	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RD16_RS18395	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RD16_RS18400	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RD16_RS18405	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RD16_RS18410	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RD16_RS18415	COG0202	RNA polymerase activity
RD16_RS18420	COG0203	ribosomal protein L17
RD16_RS18430	COG1324	tolerance protein
RD16_RS18435	COG4232	protein-disulfide reductase activity
RD16_RS18450	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RD16_RS18460	COG1333	cytochrome c biogenesis protein
RD16_RS18465	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RD16_RS18475	COG1965	Belongs to the frataxin family
RD16_RS18485	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RD16_RS18490	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RD16_RS18495	COG0232	Belongs to the dGTPase family. Type 2 subfamily
RD16_RS18510	COG2814	Major facilitator Superfamily
RD16_RS18515	COG0629	single-stranded DNA binding
RD16_RS18555	COG0402	S-adenosylhomocysteine deaminase activity
RD16_RS18565	COG0438	transferase activity, transferring glycosyl groups
RD16_RS18585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD16_RS18610	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RD16_RS18615	COG2186	Transcriptional regulator
RD16_RS18635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RD16_RS18640	COG1956	GAF domain-containing protein
RD16_RS18645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RD16_RS18655	COG1652	LysM domain
RD16_RS18670	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RD16_RS18685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RD16_RS18710	COG3181	Tripartite tricarboxylate transporter family receptor
RD16_RS18725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD16_RS18740	COG1024	Enoyl-CoA hydratase
RD16_RS18755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD16_RS18760	COG1309	transcriptional regulator
RD16_RS18765	COG2816	NAD+ diphosphatase activity
RD16_RS18770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RD16_RS18855	COG2814	Major facilitator Superfamily
RD16_RS18860	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RD16_RS18880	COG1999	signal sequence binding
RD16_RS18885	COG0109	protoheme IX farnesyltransferase activity
RD16_RS18925	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RD16_RS18945	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RD16_RS18950	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RD16_RS18960	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
RD16_RS18965	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
RD16_RS18975	COG0069	glutamate synthase activity
RD16_RS18975	COG0067	glutamate synthase
RD16_RS18975	COG0070	glutamate synthase
RD16_RS18985	COG3047	cAMP biosynthetic process
RD16_RS18995	COG1127	ABC transporter
RD16_RS19000	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RD16_RS19005	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RD16_RS19010	COG2853	Lipoprotein
RD16_RS19025	COG0842	Transport permease protein
RD16_RS19035	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RD16_RS19040	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RD16_RS19045	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RD16_RS19050	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RD16_RS19055	COG0131	Imidazoleglycerol-phosphate dehydratase
RD16_RS19060	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RD16_RS19065	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RD16_RS19070	COG0107	imidazoleglycerol-phosphate synthase activity
RD16_RS19075	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RD16_RS19080	COG0140	phosphoribosyl-ATP diphosphatase activity
RD16_RS19085	COG0537	adenosine 5'-monophosphoramidase activity
RD16_RS19090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RD16_RS19095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RD16_RS19110	COG3181	Tripartite tricarboxylate transporter family receptor
RD16_RS19145	COG3702	type iv secretory pathway
RD16_RS19150	COG3451	type IV secretory pathway VirB4
RD16_RS19165	COG3736	Type IV secretory pathway, component VirB8
RD16_RS19170	COG3504	Conjugal transfer protein
RD16_RS19175	COG2948	multi-organism process
RD16_RS19180	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
RD16_RS19190	COG0697	spore germination
RD16_RS19210	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RD16_RS19215	COG0747	negative chemotaxis
RD16_RS19220	COG0601	transmembrane transport
RD16_RS19225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD16_RS19230	COG0444	Belongs to the ABC transporter superfamily
RD16_RS19240	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
RD16_RS19250	COG0494	nUDIX hydrolase
RD16_RS19285	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
RD16_RS19290	COG0237	dephospho-CoA kinase activity
RD16_RS19295	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
RD16_RS19310	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RD16_RS19315	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
RD16_RS19325	COG0477	Major facilitator Superfamily
RD16_RS19330	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RD16_RS19345	COG1126	abc transporter atp-binding protein
RD16_RS19350	COG0765	amino acid transport
RD16_RS19355	COG4597	amino acid ABC transporter
RD16_RS19360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD16_RS19365	COG2884	Cell division ATP-binding protein ftsE
RD16_RS19370	COG2177	Part of the ABC transporter FtsEX involved in
RD16_RS19375	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
RD16_RS19385	COG1194	a g-specific adenine glycosylase
RD16_RS19395	COG2226	methyltransferase
RD16_RS19405	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD16_RS19410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD16_RS19425	COG1024	Enoyl-CoA hydratase
RD16_RS19445	COG1024	Enoyl-CoA hydratase
RD16_RS19450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD16_RS19455	COG3181	Tripartite tricarboxylate transporter family receptor
RD16_RS19465	COG0753	catalase activity
RD16_RS19470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD16_RS19475	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
RD16_RS19485	COG2175	clavaminate synthase activity
RD16_RS19490	COG1473	amidohydrolase
RD16_RS19495	COG4608	Belongs to the ABC transporter superfamily
RD16_RS19500	COG0444	Belongs to the ABC transporter superfamily
RD16_RS19515	COG0747	negative chemotaxis
RD16_RS19520	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RD16_RS19555	COG0436	Aminotransferase
RD16_RS19560	COG1278	Cold shock