locus-tag	class	description
BFW77_RS00005	COG0445	tRNA wobble uridine modification
BFW77_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
BFW77_RS00015	COG1192	Involved in chromosome partitioning
BFW77_RS00025	COG1475	DNA binding
BFW77_RS00050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BFW77_RS00060	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BFW77_RS00070	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BFW77_RS00075	COG0081	regulation of translation
BFW77_RS00080	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BFW77_RS00085	COG0222	ribosome binding
BFW77_RS00090	COG0085	RNA polymerase activity
BFW77_RS00095	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BFW77_RS00135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BFW77_RS00160	COG1024	Enoyl-CoA hydratase
BFW77_RS00180	COG0752	glycyl-tRNA synthetase alpha subunit
BFW77_RS00185	COG0751	glycine-tRNA ligase activity
BFW77_RS00190	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BFW77_RS00195	COG0204	Acyl-transferase
BFW77_RS00210	COG0242	peptide deformylase activity
BFW77_RS00245	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BFW77_RS00260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BFW77_RS00265	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BFW77_RS00265	COG2813	Specifically methylates the guanine in position
BFW77_RS00280	COG2223	nitrite transmembrane transporter activity
BFW77_RS00290	COG1794	racemase activity, acting on amino acids and derivatives
BFW77_RS00295	COG1126	abc transporter atp-binding protein
BFW77_RS00300	COG0765	amino acid transport
BFW77_RS00305	COG0765	amino acid transport
BFW77_RS00310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BFW77_RS00375	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BFW77_RS00405	COG0326	Molecular chaperone. Has ATPase activity
BFW77_RS00410	COG0625	glutathione transferase activity
BFW77_RS00425	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BFW77_RS00430	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BFW77_RS00460	COG0438	transferase activity, transferring glycosyl groups
BFW77_RS00465	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BFW77_RS00470	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BFW77_RS00500	COG0859	PFAM glycosyl transferase family 9
BFW77_RS00515	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BFW77_RS00525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BFW77_RS00530	COG1127	ABC transporter
BFW77_RS00550	COG1686	Belongs to the peptidase S11 family
BFW77_RS00560	COG2921	Belongs to the UPF0250 family
BFW77_RS00565	COG0321	lipoyl(octanoyl) transferase activity
BFW77_RS00570	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BFW77_RS00605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BFW77_RS00615	COG0018	arginyl-trna synthetase
BFW77_RS00635	COG0395	ABC-type sugar transport system, permease component
BFW77_RS00640	COG1175	transmembrane transport
BFW77_RS00645	COG1653	transport
BFW77_RS00650	COG3842	ATPase activity
BFW77_RS00655	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BFW77_RS00665	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BFW77_RS00685	COG1609	Transcriptional regulator
BFW77_RS00695	COG0154	amidase activity
BFW77_RS00700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BFW77_RS00710	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BFW77_RS00720	COG0583	DNA-binding transcription factor activity
BFW77_RS00735	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BFW77_RS00740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BFW77_RS00755	COG1802	Transcriptional regulator
BFW77_RS00770	COG1024	Enoyl-CoA hydratase
BFW77_RS00785	COG3181	Tripartite tricarboxylate transporter family receptor
BFW77_RS00800	COG1984	allophanate hydrolase subunit 2
BFW77_RS00805	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BFW77_RS00815	COG0583	DNA-binding transcription factor activity
BFW77_RS00820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BFW77_RS00830	COG5002	protein histidine kinase activity
BFW77_RS00840	COG5002	protein histidine kinase activity
BFW77_RS00845	COG0745	RESPONSE REGULATOR receiver
BFW77_RS00850	COG2226	methyltransferase
BFW77_RS00865	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BFW77_RS00885	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
BFW77_RS00895	COG0513	Belongs to the DEAD box helicase family
BFW77_RS00900	COG1280	lysine exporter protein (LysE YggA)
BFW77_RS00905	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BFW77_RS00940	COG1054	Belongs to the UPF0176 family
BFW77_RS00945	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BFW77_RS00945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BFW77_RS00955	COG0489	protein tyrosine kinase activity
BFW77_RS00970	COG0717	Belongs to the dCTP deaminase family
BFW77_RS01000	COG2081	HI0933 family
BFW77_RS01020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BFW77_RS01030	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BFW77_RS01035	COG0509	glycine decarboxylation via glycine cleavage system
BFW77_RS01040	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BFW77_RS01040	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BFW77_RS01080	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BFW77_RS01095	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BFW77_RS01105	COG1414	Transcriptional regulator
BFW77_RS01110	COG1028	Short-chain dehydrogenase reductase Sdr
BFW77_RS01115	COG2031	fatty acid transporter
BFW77_RS01120	COG1250	3-hydroxyacyl-CoA dehydrogenase
BFW77_RS01130	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BFW77_RS01135	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BFW77_RS01145	COG4257	antibiotic catabolic process
BFW77_RS01170	COG1012	belongs to the aldehyde dehydrogenase family
BFW77_RS01175	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BFW77_RS01180	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BFW77_RS01205	COG1028	Short-chain dehydrogenase reductase Sdr
BFW77_RS01215	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BFW77_RS01225	COG2188	Transcriptional regulator
BFW77_RS01230	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BFW77_RS01255	COG0617	tRNA 3'-terminal CCA addition
BFW77_RS01270	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BFW77_RS01275	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BFW77_RS01280	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BFW77_RS01285	COG0586	Pfam SNARE associated Golgi protein
BFW77_RS01290	COG0860	N-Acetylmuramoyl-L-alanine amidase
BFW77_RS01295	COG0802	atpase or kinase
BFW77_RS01300	COG0114	fumarate hydratase activity
BFW77_RS01310	COG3181	Tripartite tricarboxylate transporter family receptor
BFW77_RS01320	COG0405	Gamma-glutamyltransferase
BFW77_RS01325	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BFW77_RS01335	COG1960	acyl-CoA dehydrogenase activity
BFW77_RS01360	COG1294	oxidase, subunit
BFW77_RS01370	COG4988	ABC transporter
BFW77_RS01375	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BFW77_RS01395	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BFW77_RS01425	COG2969	positive regulation of protein catabolic process
BFW77_RS01430	COG0625	glutathione transferase activity
BFW77_RS01435	COG2857	Cytochrome c1
BFW77_RS01440	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BFW77_RS01445	COG0723	plastoquinol--plastocyanin reductase activity
BFW77_RS01450	COG1970	mechanosensitive ion channel activity
BFW77_RS01455	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BFW77_RS01470	COG2808	Putative FMN-binding domain
BFW77_RS01475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BFW77_RS01480	COG0747	negative chemotaxis
BFW77_RS01485	COG0657	acetylesterase activity
BFW77_RS01495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BFW77_RS01500	COG2207	Transcriptional regulator
BFW77_RS01505	COG0129	dihydroxy-acid dehydratase activity
BFW77_RS01510	COG2814	Major facilitator Superfamily
BFW77_RS01515	COG0583	DNA-binding transcription factor activity
BFW77_RS01525	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
BFW77_RS01595	COG1024	Enoyl-CoA hydratase
BFW77_RS01600	COG1960	acyl-CoA dehydrogenase activity
BFW77_RS01625	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BFW77_RS01630	COG0352	thiamine-phosphate diphosphorylase activity
BFW77_RS01645	COG1678	Uncharacterized ACR, COG1678
BFW77_RS01650	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BFW77_RS01655	COG0540	Belongs to the ATCase OTCase family
BFW77_RS01670	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BFW77_RS01680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BFW77_RS01715	COG1234	tRNA 3'-trailer cleavage
BFW77_RS01725	COG0583	DNA-binding transcription factor activity
BFW77_RS01735	COG3064	Membrane
BFW77_RS01765	COG1683	Conserved Protein
BFW77_RS01770	COG1120	ATPase activity
BFW77_RS01775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BFW77_RS01780	COG4558	Periplasmic binding protein
BFW77_RS01785	COG3720	iron ion transport
BFW77_RS01795	COG3712	iron ion homeostasis
BFW77_RS01800	COG1595	DNA-templated transcription, initiation
BFW77_RS01835	COG1802	Transcriptional regulator
BFW77_RS01845	COG3069	C4-dicarboxylate transmembrane transporter activity
BFW77_RS01855	COG1012	belongs to the aldehyde dehydrogenase family
BFW77_RS01890	COG2860	membrane
BFW77_RS01895	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BFW77_RS01900	COG0708	Exodeoxyribonuclease III
BFW77_RS01905	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BFW77_RS01910	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BFW77_RS01915	COG0154	amidase activity
BFW77_RS01920	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BFW77_RS01925	COG1077	Cell shape determining protein MreB Mrl
BFW77_RS01930	COG1792	Involved in formation and maintenance of cell shape
BFW77_RS01940	COG0768	penicillin binding
BFW77_RS01945	COG0772	Belongs to the SEDS family
BFW77_RS01950	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BFW77_RS01955	COG0471	metal ion transport
BFW77_RS01960	COG1309	transcriptional regulator
BFW77_RS01970	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BFW77_RS01985	COG2823	Periplasmic or secreted lipoprotein
BFW77_RS01990	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BFW77_RS02005	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BFW77_RS02025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BFW77_RS02035	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BFW77_RS02055	COG0492	ferredoxin-NADP+ reductase activity
BFW77_RS02065	COG3181	Tripartite tricarboxylate transporter family receptor
BFW77_RS02070	COG1250	3-hydroxyacyl-CoA dehydrogenase
BFW77_RS02070	COG1024	Enoyl-CoA hydratase
BFW77_RS02075	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BFW77_RS02080	COG0028	Belongs to the TPP enzyme family
BFW77_RS02105	COG3181	Tripartite tricarboxylate transporter family receptor
BFW77_RS02115	COG0697	spore germination
BFW77_RS02145	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BFW77_RS02150	COG0463	Glycosyl transferase, family 2
BFW77_RS02165	COG0786	glutamate:sodium symporter activity
BFW77_RS02175	COG2031	fatty acid transporter
BFW77_RS02190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BFW77_RS02195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BFW77_RS02220	COG3181	Tripartite tricarboxylate transporter family receptor
BFW77_RS02230	COG0277	FAD linked oxidase domain protein
BFW77_RS02235	COG1960	acyl-CoA dehydrogenase activity
BFW77_RS02240	COG1960	acyl-CoA dehydrogenase activity
BFW77_RS02250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BFW77_RS02265	COG2072	flavoprotein involved in K transport
BFW77_RS02270	COG0604	alcohol dehydrogenase
BFW77_RS02285	COG1024	Enoyl-CoA hydratase
BFW77_RS02305	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BFW77_RS02310	COG1522	sequence-specific DNA binding
BFW77_RS02315	COG0183	Belongs to the thiolase family
BFW77_RS02325	COG1960	acyl-CoA dehydrogenase activity
BFW77_RS02370	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BFW77_RS02375	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BFW77_RS02380	COG2890	protein-(glutamine-N5) methyltransferase activity
BFW77_RS02385	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BFW77_RS02395	COG3181	Tripartite tricarboxylate transporter family receptor
BFW77_RS02430	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BFW77_RS02435	COG1660	Displays ATPase and GTPase activities
BFW77_RS02445	COG2010	Cytochrome c
BFW77_RS02445	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BFW77_RS02450	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BFW77_RS02465	COG1137	ATPase activity
BFW77_RS02480	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BFW77_RS02490	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BFW77_RS02525	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BFW77_RS02530	COG3568	Endonuclease Exonuclease Phosphatase
BFW77_RS02535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BFW77_RS02565	COG0154	amidase activity
BFW77_RS02575	COG1414	Transcriptional regulator
BFW77_RS02585	COG1250	3-hydroxyacyl-CoA dehydrogenase
BFW77_RS02585	COG1024	Enoyl-CoA hydratase
BFW77_RS02595	COG2132	Multicopper oxidase
BFW77_RS02625	COG1250	3-hydroxyacyl-CoA dehydrogenase
BFW77_RS02650	COG1024	Enoyl-CoA hydratase
BFW77_RS02655	COG1024	Enoyl-CoA hydratase
BFW77_RS02660	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BFW77_RS02680	COG0601	transmembrane transport
BFW77_RS02685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BFW77_RS02690	COG4172	Belongs to the ABC transporter superfamily
BFW77_RS02700	COG2195	Cleaves the N-terminal amino acid of tripeptides
BFW77_RS02710	COG0210	DNA helicase
BFW77_RS02715	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BFW77_RS02720	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BFW77_RS02730	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BFW77_RS02735	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BFW77_RS02740	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BFW77_RS02745	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BFW77_RS02750	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BFW77_RS02755	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BFW77_RS02765	COG0356	it plays a direct role in the translocation of protons across the membrane
BFW77_RS02790	COG1024	Enoyl-CoA hydratase
BFW77_RS02795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFW77_RS02800	COG3634	alkyl hydroperoxide reductase activity
BFW77_RS02810	COG0037	tRNA processing
BFW77_RS02820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BFW77_RS02825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BFW77_RS02830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BFW77_RS02835	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
BFW77_RS02840	COG2967	ApaG domain
BFW77_RS02845	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BFW77_RS02850	COG0546	phosphoglycolate phosphatase activity
BFW77_RS02860	COG0512	Glutamine amidotransferase of anthranilate synthase
BFW77_RS02865	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BFW77_RS02870	COG0134	indole-3-glycerol-phosphate synthase activity
BFW77_RS02890	COG1960	acyl-CoA dehydrogenase activity
BFW77_RS02895	COG0583	DNA-binding transcription factor activity
BFW77_RS02910	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BFW77_RS02915	COG0259	pyridoxamine-phosphate oxidase activity
BFW77_RS02925	COG2814	Major facilitator Superfamily
BFW77_RS02930	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BFW77_RS02935	COG2188	Transcriptional regulator
BFW77_RS02940	COG0318	PFAM AMP-dependent synthetase and ligase
BFW77_RS02960	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BFW77_RS02970	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BFW77_RS02985	COG1215	transferase activity, transferring glycosyl groups
BFW77_RS02995	COG0601	transmembrane transport
BFW77_RS03010	COG0488	(ABC) transporter
BFW77_RS03030	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BFW77_RS03035	COG2894	cell division
BFW77_RS03040	COG0850	regulation of cytokinetic process
BFW77_RS03045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BFW77_RS03050	COG1271	oxidase subunit
BFW77_RS03085	COG2979	Protein of unknown function (DUF533)
BFW77_RS03105	COG0741	lytic transglycosylase activity
BFW77_RS03105	COG1388	LysM domain
BFW77_RS03110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BFW77_RS03115	COG2226	methyltransferase
BFW77_RS03120	COG0328	RNA-DNA hybrid ribonuclease activity
BFW77_RS03165	COG2030	dehydratase
BFW77_RS03170	COG0183	Belongs to the thiolase family
BFW77_RS03215	COG1960	acyl-CoA dehydrogenase activity
BFW77_RS03230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BFW77_RS03235	COG1028	Short-chain dehydrogenase reductase Sdr
BFW77_RS03250	COG2718	Belongs to the UPF0229 family
BFW77_RS03255	COG2719	SpoVR family
BFW77_RS03280	COG2188	Transcriptional regulator
BFW77_RS03295	COG0633	Ferredoxin
BFW77_RS03305	COG0829	nickel cation binding
BFW77_RS03310	COG0831	urea catabolic process
BFW77_RS03320	COG0832	Belongs to the urease beta subunit family
BFW77_RS03325	COG0804	urea catabolic process
BFW77_RS03335	COG0830	nickel cation binding
BFW77_RS03340	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BFW77_RS03360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BFW77_RS03365	COG0601	transmembrane transport
BFW77_RS03370	COG0747	negative chemotaxis
BFW77_RS03380	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BFW77_RS03385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BFW77_RS03395	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BFW77_RS03405	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BFW77_RS03410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BFW77_RS03415	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BFW77_RS03430	COG0438	transferase activity, transferring glycosyl groups
BFW77_RS03445	COG0438	transferase activity, transferring glycosyl groups
BFW77_RS03450	COG0438	transferase activity, transferring glycosyl groups
BFW77_RS03455	COG0166	Belongs to the GPI family
BFW77_RS03470	COG0277	FAD linked oxidase domain protein
BFW77_RS03475	COG0745	RESPONSE REGULATOR receiver
BFW77_RS03480	COG0642	Histidine kinase
BFW77_RS03485	COG1368	sulfuric ester hydrolase activity
BFW77_RS03495	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BFW77_RS03520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BFW77_RS03530	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BFW77_RS03535	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BFW77_RS03545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BFW77_RS03550	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BFW77_RS03555	COG0193	aminoacyl-tRNA hydrolase activity
BFW77_RS03565	COG0012	GTP binding
BFW77_RS03570	COG0582	viral genome integration into host DNA
BFW77_RS03595	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BFW77_RS03650	COG0745	RESPONSE REGULATOR receiver
BFW77_RS03665	COG1309	transcriptional regulator
BFW77_RS03695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BFW77_RS03705	COG0405	Gamma-glutamyltransferase
BFW77_RS03720	COG1280	lysine exporter protein (LysE YggA)
BFW77_RS03780	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BFW77_RS03785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BFW77_RS03795	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BFW77_RS03800	COG0513	Belongs to the DEAD box helicase family
BFW77_RS03810	COG0617	tRNA 3'-terminal CCA addition
BFW77_RS03825	COG0477	Major facilitator Superfamily
BFW77_RS03835	COG0583	DNA-binding transcription factor activity
BFW77_RS03850	COG1950	PFAM Membrane protein of
BFW77_RS03855	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BFW77_RS03870	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BFW77_RS03880	COG1560	Kdo2-lipid A biosynthetic process
BFW77_RS03885	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BFW77_RS03895	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BFW77_RS03905	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
BFW77_RS03915	COG0803	Belongs to the bacterial solute-binding protein 9 family
BFW77_RS03935	COG0735	belongs to the Fur family
BFW77_RS03940	COG0523	cobalamin synthesis protein
BFW77_RS03950	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BFW77_RS03955	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BFW77_RS03970	COG2096	Adenosyltransferase
BFW77_RS03985	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BFW77_RS03990	COG2084	Dehydrogenase
BFW77_RS04040	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BFW77_RS04045	COG0129	dihydroxy-acid dehydratase activity
BFW77_RS04050	COG4654	Cytochrome c, class I
BFW77_RS04055	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BFW77_RS04105	COG1473	amidohydrolase
BFW77_RS04110	COG0418	dihydroorotase activity
BFW77_RS04115	COG0488	(ABC) transporter
BFW77_RS04125	COG2001	Belongs to the MraZ family
BFW77_RS04130	COG0275	rRNA processing
BFW77_RS04135	COG3116	cell division
BFW77_RS04145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BFW77_RS04150	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BFW77_RS04155	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BFW77_RS04165	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BFW77_RS04170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BFW77_RS04175	COG1181	Belongs to the D-alanine--D-alanine ligase family
BFW77_RS04180	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BFW77_RS04190	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BFW77_RS04195	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BFW77_RS04205	COG0739	heme binding
BFW77_RS04210	COG0653	protein targeting
BFW77_RS04230	COG1028	Short-chain dehydrogenase reductase Sdr
BFW77_RS04235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BFW77_RS04240	COG1522	sequence-specific DNA binding
BFW77_RS04260	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BFW77_RS04270	COG0557	exoribonuclease II activity
BFW77_RS04275	COG3150	esterase
BFW77_RS04280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BFW77_RS04285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BFW77_RS04290	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BFW77_RS04295	COG0511	ligase activity, forming carbon-carbon bonds
BFW77_RS04300	COG0439	Biotin carboxylase
BFW77_RS04305	COG2264	protein methyltransferase activity
BFW77_RS04315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BFW77_RS04340	COG1696	Membrane protein involved in D-alanine export
BFW77_RS04345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BFW77_RS04380	COG1522	sequence-specific DNA binding
BFW77_RS04395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BFW77_RS04400	COG0045	succinate-CoA ligase (ADP-forming) activity
BFW77_RS04400	COG1042	CoA-binding domain protein
BFW77_RS04400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BFW77_RS04415	COG1802	Transcriptional regulator
BFW77_RS04420	COG3069	C4-dicarboxylate transmembrane transporter activity
BFW77_RS04425	COG0513	Belongs to the DEAD box helicase family
BFW77_RS04430	COG0346	lactoylglutathione lyase activity
BFW77_RS04435	COG1335	isochorismatase
BFW77_RS04440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BFW77_RS04445	COG1116	anion transmembrane transporter activity
BFW77_RS04460	COG3028	Belongs to the UPF0307 family
BFW77_RS04465	COG0312	modulator of DNA gyrase
BFW77_RS04470	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BFW77_RS04475	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BFW77_RS04480	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BFW77_RS04485	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BFW77_RS04495	COG0316	Belongs to the HesB IscA family
BFW77_RS04500	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BFW77_RS04515	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BFW77_RS04525	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BFW77_RS04530	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BFW77_RS04545	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BFW77_RS04545	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BFW77_RS04580	COG0583	DNA-binding transcription factor activity
BFW77_RS04585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BFW77_RS04620	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BFW77_RS04630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BFW77_RS04635	COG1845	cytochrome c oxidase, subunit III
BFW77_RS04640	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BFW77_RS04645	COG0640	Transcriptional regulator
BFW77_RS04665	COG3220	belongs to the UPF0276 family
BFW77_RS04710	COG1666	GTP binding
BFW77_RS04745	COG0312	modulator of DNA gyrase
BFW77_RS04750	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BFW77_RS04755	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
BFW77_RS04755	COG3210	domain, Protein
BFW77_RS04755	COG3064	Membrane
BFW77_RS04755	COG3210	domain, Protein
BFW77_RS04755	COG3064	Membrane
BFW77_RS04755	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
BFW77_RS04760	COG0277	FAD linked oxidase domain protein
BFW77_RS04765	COG0277	FAD linked oxidase domain protein
BFW77_RS04770	COG0277	FAD linked oxidase domain protein
BFW77_RS04775	COG0247	lactate metabolic process
BFW77_RS04780	COG2819	hydrolase of the alpha beta superfamily
BFW77_RS04800	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BFW77_RS04820	COG0583	DNA-binding transcription factor activity
BFW77_RS04825	COG0482	sulfurtransferase activity
BFW77_RS04830	COG0730	response to heat
BFW77_RS04835	COG0625	glutathione transferase activity
BFW77_RS04840	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BFW77_RS04845	COG3909	cytochrome
BFW77_RS04885	COG0154	amidase activity
BFW77_RS04890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BFW77_RS04895	COG1024	Enoyl-CoA hydratase
BFW77_RS04910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BFW77_RS04925	COG1028	Short-chain dehydrogenase reductase Sdr
BFW77_RS04930	COG1414	Transcriptional regulator
BFW77_RS04940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BFW77_RS04945	COG0251	oxidation-reduction process
BFW77_RS04950	COG0559	Belongs to the binding-protein-dependent transport system permease family
BFW77_RS04970	COG1902	pentaerythritol trinitrate reductase activity
BFW77_RS04985	COG0583	DNA-binding transcription factor activity
BFW77_RS04995	COG0590	tRNA wobble adenosine to inosine editing
BFW77_RS05000	COG2807	transmembrane transport
BFW77_RS05010	COG3181	Tripartite tricarboxylate transporter family receptor
BFW77_RS05020	COG0154	amidase activity
BFW77_RS05025	COG0307	riboflavin synthase, alpha
BFW77_RS05030	COG3181	Tripartite tricarboxylate transporter family receptor
BFW77_RS05035	COG1522	sequence-specific DNA binding
BFW77_RS05045	COG0318	PFAM AMP-dependent synthetase and ligase
BFW77_RS05055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BFW77_RS05075	COG1063	alcohol dehydrogenase
BFW77_RS05100	COG1418	mRNA catabolic process
BFW77_RS05105	COG1448	Aminotransferase
BFW77_RS05110	COG0583	DNA-binding transcription factor activity
BFW77_RS05120	COG0477	Major facilitator Superfamily
BFW77_RS05125	COG1028	Short-chain dehydrogenase reductase Sdr
BFW77_RS05140	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BFW77_RS05145	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BFW77_RS05150	COG0583	DNA-binding transcription factor activity
BFW77_RS05210	COG1028	Short-chain dehydrogenase reductase Sdr
BFW77_RS05215	COG1309	transcriptional regulator
BFW77_RS05225	COG2982	Protein involved in outer membrane biogenesis
BFW77_RS05230	COG2818	Glycosylase
BFW77_RS05250	COG1653	transport
BFW77_RS05260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BFW77_RS05265	COG3842	ATPase activity
BFW77_RS05270	COG0395	ABC-type sugar transport system, permease component
BFW77_RS05275	COG1175	transmembrane transport
BFW77_RS05295	COG3181	Tripartite tricarboxylate transporter family receptor
BFW77_RS05300	COG2186	Transcriptional regulator
BFW77_RS05330	COG1454	alcohol dehydrogenase
BFW77_RS05350	COG2011	ABC-type metal ion transport system permease component
BFW77_RS05355	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BFW77_RS05360	COG1501	Belongs to the glycosyl hydrolase 31 family
BFW77_RS05385	COG0318	PFAM AMP-dependent synthetase and ligase
BFW77_RS05390	COG1473	amidohydrolase
BFW77_RS05400	COG2855	membrane
BFW77_RS05410	COG2239	Acts as a magnesium transporter
BFW77_RS05430	COG3181	Tripartite tricarboxylate transporter family receptor
BFW77_RS05440	COG1722	exodeoxyribonuclease VII activity
BFW77_RS05445	COG0142	geranyltranstransferase activity
BFW77_RS05450	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BFW77_RS05455	COG1469	GTP cyclohydrolase I activity
BFW77_RS05460	COG0360	Binds together with S18 to 16S ribosomal RNA
BFW77_RS05465	COG2965	DNA replication, synthesis of RNA primer
BFW77_RS05470	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BFW77_RS05475	COG0359	binds to the 23S rRNA
BFW77_RS05485	COG0305	Participates in initiation and elongation during chromosome replication
BFW77_RS05495	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BFW77_RS05500	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BFW77_RS05505	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BFW77_RS05510	COG3737	Protein of unknown function (DUF498/DUF598)
BFW77_RS05515	COG0436	Aminotransferase
BFW77_RS05540	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BFW77_RS05575	COG0268	Binds directly to 16S ribosomal RNA
BFW77_RS05585	COG0728	peptidoglycan biosynthetic process
BFW77_RS05595	COG0563	adenylate kinase activity
BFW77_RS05600	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BFW77_RS05605	COG2835	tetraacyldisaccharide 4'-kinase activity
BFW77_RS05610	COG1663	tetraacyldisaccharide 4'-kinase activity
BFW77_RS05615	COG0848	biopolymer transport protein
BFW77_RS05620	COG0811	peptide transport
BFW77_RS05630	COG1570	exodeoxyribonuclease VII activity
BFW77_RS05635	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BFW77_RS05640	COG0038	chloride channel
BFW77_RS05645	COG0183	Belongs to the thiolase family
BFW77_RS05655	COG1278	Cold shock
BFW77_RS05660	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BFW77_RS05670	COG4953	penicillin-binding protein 1C
BFW77_RS05675	COG0542	response to heat
BFW77_RS05680	COG2995	paraquat-inducible protein a
BFW77_RS05685	COG3008	intermembrane lipid transfer
BFW77_RS05685	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BFW77_RS05695	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BFW77_RS05695	COG0506	proline dehydrogenase activity
BFW77_RS05695	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BFW77_RS05730	COG2271	Major facilitator Superfamily
BFW77_RS05735	COG1309	transcriptional regulator
BFW77_RS05770	COG0477	Major facilitator Superfamily
BFW77_RS05780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BFW77_RS05785	COG1845	cytochrome c oxidase, subunit III
BFW77_RS05790	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BFW77_RS05800	COG1028	Short-chain dehydrogenase reductase Sdr
BFW77_RS05820	COG0789	Transcriptional regulator
BFW77_RS05845	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BFW77_RS05850	COG0697	spore germination
BFW77_RS05860	COG0678	peroxiredoxin activity
BFW77_RS05870	COG0412	Dienelactone hydrolase
BFW77_RS05880	COG0315	cyclic pyranopterin monophosphate synthase activity
BFW77_RS05895	COG0521	Mo-molybdopterin cofactor biosynthetic process
BFW77_RS05900	COG0303	'Molybdopterin
BFW77_RS05905	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BFW77_RS05925	COG0165	Argininosuccinate lyase
BFW77_RS05930	COG0668	transmembrane transport
BFW77_RS05975	COG0747	negative chemotaxis
BFW77_RS05980	COG0601	transmembrane transport
BFW77_RS05985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BFW77_RS05995	COG1162	GTPase activity
BFW77_RS06000	COG0501	Belongs to the peptidase M48B family
BFW77_RS06005	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BFW77_RS06015	COG3327	negative regulation of DNA-templated transcription, initiation
BFW77_RS06020	COG3396	Phenylacetate-CoA oxygenase
BFW77_RS06025	COG3460	Phenylacetate-CoA oxygenase
BFW77_RS06030	COG3396	Phenylacetate-CoA oxygenase
BFW77_RS06035	COG2151	metal-sulfur cluster biosynthetic enzyme
BFW77_RS06040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BFW77_RS06055	COG1012	belongs to the aldehyde dehydrogenase family
BFW77_RS06060	COG1024	Enoyl-CoA hydratase
BFW77_RS06065	COG2050	protein possibly involved in aromatic compounds catabolism
BFW77_RS06075	COG3539	Fimbrial protein
BFW77_RS06095	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BFW77_RS06100	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BFW77_RS06100	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BFW77_RS06105	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BFW77_RS06110	COG0047	phosphoribosylformylglycinamidine synthase activity
BFW77_RS06110	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BFW77_RS06115	COG3210	domain, Protein
BFW77_RS06115	COG3064	Membrane
BFW77_RS06115	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
BFW77_RS06145	COG0235	Class ii aldolase
BFW77_RS06150	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BFW77_RS06155	COG0720	synthase
BFW77_RS06160	COG0602	queuosine metabolic process
BFW77_RS06185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BFW77_RS06220	COG3181	Tripartite tricarboxylate transporter family receptor
BFW77_RS06245	COG3842	ATPase activity
BFW77_RS06255	COG0395	ABC-type sugar transport system, permease component
BFW77_RS06285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BFW77_RS06290	COG0420	3'-5' exonuclease activity
BFW77_RS06330	COG0519	Catalyzes the synthesis of GMP from XMP
BFW77_RS06330	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BFW77_RS06345	COG3550	peptidyl-serine autophosphorylation
BFW77_RS06355	COG0477	Major facilitator Superfamily
BFW77_RS06370	COG1228	amidohydrolase
BFW77_RS06380	COG1116	anion transmembrane transporter activity
BFW77_RS06385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BFW77_RS06420	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BFW77_RS06440	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BFW77_RS06470	COG2814	Major facilitator Superfamily
BFW77_RS06485	COG1280	lysine exporter protein (LysE YggA)
BFW77_RS06500	COG0747	negative chemotaxis
BFW77_RS06505	COG0601	transmembrane transport
BFW77_RS06510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BFW77_RS06515	COG4172	Belongs to the ABC transporter superfamily
BFW77_RS06520	COG1609	Transcriptional regulator
BFW77_RS06550	COG0586	Pfam SNARE associated Golgi protein
BFW77_RS06565	COG0500	methyltransferase
BFW77_RS06580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BFW77_RS06590	COG0756	dUTP diphosphatase activity
BFW77_RS06605	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BFW77_RS06610	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BFW77_RS06615	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BFW77_RS06620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BFW77_RS06620	COG0072	phenylalanine-tRNA ligase activity
BFW77_RS06625	COG0776	regulation of translation
BFW77_RS06695	COG0540	Belongs to the ATCase OTCase family
BFW77_RS06700	COG2974	May be involved in recombination
BFW77_RS06710	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BFW77_RS06715	COG0583	DNA-binding transcription factor activity
BFW77_RS06735	COG1028	Short-chain dehydrogenase reductase Sdr
BFW77_RS06750	COG3842	ATPase activity
BFW77_RS06755	COG1250	3-hydroxyacyl-CoA dehydrogenase
BFW77_RS06755	COG1024	Enoyl-CoA hydratase
BFW77_RS06775	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BFW77_RS06780	COG2137	regulation of response to DNA damage stimulus
BFW77_RS06790	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BFW77_RS06800	COG0045	succinate-CoA ligase (ADP-forming) activity
BFW77_RS06805	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BFW77_RS06810	COG0861	Integral membrane protein TerC family
BFW77_RS06815	COG0861	Integral membrane protein TerC family
BFW77_RS06820	COG0181	hydroxymethylbilane synthase activity
BFW77_RS06880	COG4964	Belongs to the GSP D family
BFW77_RS06905	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BFW77_RS06915	COG0583	DNA-binding transcription factor activity
BFW77_RS06925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BFW77_RS06930	COG4311	Sarcosine oxidase, delta subunit
BFW77_RS06935	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BFW77_RS06935	COG0446	pyridine nucleotide-disulphide oxidoreductase
BFW77_RS06970	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BFW77_RS06975	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BFW77_RS06980	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BFW77_RS06985	COG0735	belongs to the Fur family
BFW77_RS06990	COG0497	DNA recombination
BFW77_RS06995	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BFW77_RS07000	COG1420	regulation of RNA biosynthetic process
BFW77_RS07005	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BFW77_RS07015	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BFW77_RS07025	COG0443	Heat shock 70 kDa protein
BFW77_RS07035	COG0612	Peptidase, M16
BFW77_RS07055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BFW77_RS07110	COG0745	RESPONSE REGULATOR receiver
BFW77_RS07120	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
BFW77_RS07125	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BFW77_RS07130	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BFW77_RS07145	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BFW77_RS07165	COG1193	negative regulation of DNA recombination
BFW77_RS07170	COG0492	ferredoxin-NADP+ reductase activity
BFW77_RS07175	COG1674	ftsk spoiiie
BFW77_RS07180	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BFW77_RS07185	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BFW77_RS07190	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BFW77_RS07215	COG3706	GGDEF domain
BFW77_RS07235	COG2814	Major facilitator Superfamily
BFW77_RS07265	COG3486	L-lysine 6-monooxygenase (NADPH) activity
BFW77_RS07280	COG1028	Short-chain dehydrogenase reductase Sdr
BFW77_RS07290	COG3022	response to hydroperoxide
BFW77_RS07300	COG1289	transmembrane transporter activity
BFW77_RS07320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BFW77_RS07330	COG2197	response regulator
BFW77_RS07335	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BFW77_RS07340	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BFW77_RS07345	COG0189	ligase activity
BFW77_RS07355	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BFW77_RS07360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BFW77_RS07370	COG1764	response to oxidative stress
BFW77_RS07375	COG2423	ornithine cyclodeaminase activity
BFW77_RS07385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BFW77_RS07390	COG0765	amino acid transport
BFW77_RS07395	COG0765	amino acid transport
BFW77_RS07400	COG1126	abc transporter atp-binding protein
BFW77_RS07455	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BFW77_RS07465	COG2944	sequence-specific DNA binding
BFW77_RS07475	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BFW77_RS07480	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BFW77_RS07485	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BFW77_RS07490	COG0009	L-threonylcarbamoyladenylate synthase
BFW77_RS07495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BFW77_RS07500	COG1414	Transcriptional regulator
BFW77_RS07515	COG0765	amino acid transport
BFW77_RS07520	COG1126	abc transporter atp-binding protein
BFW77_RS07525	COG0028	Belongs to the TPP enzyme family
BFW77_RS07540	COG0028	Belongs to the TPP enzyme family
BFW77_RS07545	COG0583	DNA-binding transcription factor activity
BFW77_RS07550	COG4974	Belongs to the 'phage' integrase family
BFW77_RS07555	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BFW77_RS07560	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BFW77_RS07575	COG1686	Belongs to the peptidase S11 family
BFW77_RS07585	COG2814	Major facilitator Superfamily
BFW77_RS07595	COG1074	ATP-dependent DNA helicase activity
BFW77_RS07605	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BFW77_RS07610	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BFW77_RS07615	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BFW77_RS07635	COG2321	neutral zinc metallopeptidase
BFW77_RS07640	COG0009	L-threonylcarbamoyladenylate synthase
BFW77_RS07690	COG3360	Dodecin
BFW77_RS07695	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BFW77_RS07700	COG2850	peptidyl-arginine hydroxylation
BFW77_RS07705	COG3539	Fimbrial protein
BFW77_RS07710	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
BFW77_RS07715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BFW77_RS07720	COG1994	Peptidase M50
BFW77_RS07730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BFW77_RS07735	COG0765	amino acid transport
BFW77_RS07740	COG1126	abc transporter atp-binding protein
BFW77_RS07745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BFW77_RS07750	COG1758	RNA polymerase activity
BFW77_RS07755	COG0194	GDP metabolic process
BFW77_RS07760	COG3258	Cytochrome c
BFW77_RS07765	COG2863	cytochrome
BFW77_RS07770	COG1028	Short-chain dehydrogenase reductase Sdr
BFW77_RS07775	COG0791	NLP P60 protein
BFW77_RS07780	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BFW77_RS07800	COG1561	YicC-like family, N-terminal region
BFW77_RS07805	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BFW77_RS07820	COG0840	transmembrane signaling receptor activity
BFW77_RS07825	COG2199	diguanylate cyclase activity
BFW77_RS07825	COG2200	EAL domain
BFW77_RS07830	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BFW77_RS07840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BFW77_RS07845	COG0174	glutamine synthetase
BFW77_RS07855	COG2204	response regulator
BFW77_RS07860	COG0583	DNA-binding transcription factor activity
BFW77_RS07865	COG1741	Belongs to the pirin family
BFW77_RS07870	COG1741	Belongs to the pirin family
BFW77_RS07880	COG3842	ATPase activity
BFW77_RS07885	COG1178	ABC-type Fe3 transport system permease component
BFW77_RS07890	COG1840	ABC-type Fe3 transport system, periplasmic component
BFW77_RS07900	COG0583	DNA-binding transcription factor activity
BFW77_RS07910	COG0656	L-ascorbic acid biosynthetic process
BFW77_RS07925	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BFW77_RS07930	COG0583	DNA-binding transcription factor activity
BFW77_RS07945	COG0783	Belongs to the Dps family
BFW77_RS07965	COG0463	Glycosyl transferase, family 2
BFW77_RS07985	COG0438	transferase activity, transferring glycosyl groups
BFW77_RS08000	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BFW77_RS08025	COG0300	oxidoreductase activity
BFW77_RS08070	COG0861	Integral membrane protein TerC family
BFW77_RS08075	COG1028	Short-chain dehydrogenase reductase Sdr
BFW77_RS08095	COG0714	Associated with various cellular activities
BFW77_RS08130	COG3119	arylsulfatase activity
BFW77_RS08155	COG2197	response regulator
BFW77_RS08165	COG2944	sequence-specific DNA binding
BFW77_RS08170	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
BFW77_RS08175	COG0625	glutathione transferase activity
BFW77_RS08205	COG0179	Fumarylacetoacetate (FAA) hydrolase
BFW77_RS08210	COG1028	Short-chain dehydrogenase reductase Sdr
BFW77_RS08255	COG0431	NADPH-dependent FMN reductase
BFW77_RS08285	COG1028	Short-chain dehydrogenase reductase Sdr
BFW77_RS08290	COG0583	DNA-binding transcription factor activity
BFW77_RS08305	COG3181	Tripartite tricarboxylate transporter family receptor
BFW77_RS08310	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BFW77_RS08310	COG2111	Na H antiporter
BFW77_RS08315	COG1006	Multisubunit Na H antiporter MnhC subunit
BFW77_RS08320	COG0651	ATP synthesis coupled electron transport
BFW77_RS08325	COG1863	multisubunit Na H antiporter MnhE subunit
BFW77_RS08330	COG2212	antiporter activity
BFW77_RS08355	COG0590	tRNA wobble adenosine to inosine editing
BFW77_RS08360	COG1619	proteins homologs of microcin C7 resistance protein MccF
BFW77_RS08365	COG1024	Enoyl-CoA hydratase
BFW77_RS08380	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BFW77_RS08385	COG0488	(ABC) transporter
BFW77_RS08420	COG1017	nitric oxide dioxygenase activity
BFW77_RS08420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BFW77_RS08425	COG1959	2 iron, 2 sulfur cluster binding
BFW77_RS08430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BFW77_RS08450	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BFW77_RS08455	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BFW77_RS08460	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BFW77_RS08465	COG0084	hydrolase, TatD family'
BFW77_RS08480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BFW77_RS08490	COG1126	abc transporter atp-binding protein
BFW77_RS08495	COG0010	Belongs to the arginase family
BFW77_RS08500	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BFW77_RS08505	COG1012	belongs to the aldehyde dehydrogenase family
BFW77_RS08515	COG0028	Belongs to the TPP enzyme family
BFW77_RS08525	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BFW77_RS08525	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BFW77_RS08535	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BFW77_RS08555	COG3189	MarR family transcriptional regulator
BFW77_RS08560	COG2010	Cytochrome c
BFW77_RS08585	COG4336	lyase activity
BFW77_RS08595	COG2205	protein histidine kinase activity
BFW77_RS08595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BFW77_RS08600	COG2197	response regulator
BFW77_RS08605	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
BFW77_RS08605	COG3210	domain, Protein
BFW77_RS08605	COG3064	Membrane
BFW77_RS08615	COG3121	Chaperone
BFW77_RS08620	COG3188	usher protein
BFW77_RS08625	COG3539	Fimbrial protein
BFW77_RS08630	COG2831	hemolysin activation secretion protein
BFW77_RS08645	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BFW77_RS08670	COG0583	DNA-binding transcription factor activity
BFW77_RS08695	COG0668	transmembrane transport
BFW77_RS08715	COG0483	inositol monophosphate 1-phosphatase activity
BFW77_RS08720	COG1253	flavin adenine dinucleotide binding
BFW77_RS08725	COG1968	undecaprenyl-diphosphatase activity
BFW77_RS08730	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BFW77_RS08745	COG0215	cysteine-tRNA ligase activity
BFW77_RS08755	COG0825	malonyl-CoA metabolic process
BFW77_RS08765	COG0037	tRNA processing
BFW77_RS08770	COG0527	aspartate kinase activity
BFW77_RS08795	COG1250	3-hydroxyacyl-CoA dehydrogenase
BFW77_RS08800	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BFW77_RS08800	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BFW77_RS08815	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BFW77_RS08820	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
BFW77_RS08825	COG1028	Short-chain dehydrogenase reductase Sdr
BFW77_RS08835	COG0583	DNA-binding transcription factor activity
BFW77_RS08860	COG3842	ATPase activity
BFW77_RS08870	COG0446	pyridine nucleotide-disulphide oxidoreductase
BFW77_RS08870	COG1902	pentaerythritol trinitrate reductase activity
BFW77_RS08875	COG1414	Transcriptional regulator
BFW77_RS08880	COG1832	CoA-binding protein
BFW77_RS08890	COG0251	oxidation-reduction process
BFW77_RS08915	COG1902	pentaerythritol trinitrate reductase activity
BFW77_RS08925	COG1215	transferase activity, transferring glycosyl groups
BFW77_RS08930	COG1649	PFAM Uncharacterised BCR, COG1649
BFW77_RS08930	COG0726	polysaccharide deacetylase
BFW77_RS08950	COG1846	Transcriptional regulator
BFW77_RS08955	COG2197	response regulator
BFW77_RS08970	COG0166	Belongs to the GPI family
BFW77_RS08975	COG1045	serine acetyltransferase
BFW77_RS08985	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BFW77_RS08990	COG0483	inositol monophosphate 1-phosphatase activity
BFW77_RS08995	COG1012	belongs to the aldehyde dehydrogenase family
BFW77_RS09000	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BFW77_RS09015	COG0210	DNA helicase
BFW77_RS09020	COG0598	Magnesium transport protein CorA
BFW77_RS09030	COG0747	negative chemotaxis
BFW77_RS09035	COG0601	transmembrane transport
BFW77_RS09040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BFW77_RS09045	COG4172	Belongs to the ABC transporter superfamily
BFW77_RS09050	COG1846	Transcriptional regulator
BFW77_RS09100	COG4964	Belongs to the GSP D family
BFW77_RS09140	COG2204	response regulator
BFW77_RS09155	COG1595	DNA-templated transcription, initiation
BFW77_RS09165	COG3474	cytochrome
BFW77_RS09170	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BFW77_RS09185	COG3384	dioxygenase
BFW77_RS09190	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BFW77_RS09215	COG2885	chlorophyll binding
BFW77_RS09250	COG0697	spore germination
BFW77_RS09255	COG0730	response to heat
BFW77_RS09275	COG0583	DNA-binding transcription factor activity
BFW77_RS09280	COG0427	acetyl-CoA hydrolase
BFW77_RS09335	COG1250	3-hydroxyacyl-CoA dehydrogenase
BFW77_RS09340	COG0154	amidase activity
BFW77_RS09350	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BFW77_RS09365	COG0495	leucyl-tRNA aminoacylation
BFW77_RS09370	COG2814	Major facilitator Superfamily
BFW77_RS09400	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BFW77_RS09405	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BFW77_RS09410	COG2814	Major facilitator Superfamily
BFW77_RS09415	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BFW77_RS09430	COG4176	ABC-type proline glycine betaine transport system permease component
BFW77_RS09440	COG1942	4-Oxalocrotonate Tautomerase
BFW77_RS09445	COG0183	Belongs to the thiolase family
BFW77_RS09455	COG1802	Transcriptional regulator
BFW77_RS09465	COG1024	Enoyl-CoA hydratase
BFW77_RS09480	COG2032	superoxide dismutase activity
BFW77_RS09495	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BFW77_RS09520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BFW77_RS09525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BFW77_RS09535	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BFW77_RS09540	COG0736	holo-[acyl-carrier-protein] synthase activity
BFW77_RS09545	COG1472	Belongs to the glycosyl hydrolase 3 family
BFW77_RS09550	COG0322	excinuclease ABC activity
BFW77_RS09555	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BFW77_RS09565	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BFW77_RS09565	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BFW77_RS09570	COG2224	Isocitrate lyase
BFW77_RS09590	COG0559	Belongs to the binding-protein-dependent transport system permease family
BFW77_RS09600	COG4638	Rieske (2fe-2S)
BFW77_RS09610	COG1024	Enoyl-CoA hydratase
BFW77_RS09620	COG0633	Ferredoxin
BFW77_RS09625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BFW77_RS09640	COG0183	Belongs to the thiolase family
BFW77_RS09685	COG2346	COG2346, Truncated hemoglobins
BFW77_RS09820	COG2207	Transcriptional regulator
BFW77_RS09870	COG1132	(ABC) transporter
BFW77_RS09895	COG0659	secondary active sulfate transmembrane transporter activity
BFW77_RS09925	COG2169	Transcriptional regulator
BFW77_RS09930	COG5507	3-demethylubiquinone-9 3-methyltransferase
BFW77_RS09935	COG0384	phenazine biosynthesis protein PhzF
BFW77_RS09940	COG0583	DNA-binding transcription factor activity
BFW77_RS09945	COG2733	membrane
BFW77_RS09960	COG1012	belongs to the aldehyde dehydrogenase family
BFW77_RS09965	COG3284	Transcriptional regulator
BFW77_RS09985	COG1380	Effector of murein hydrolase LrgA
BFW77_RS09990	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BFW77_RS09990	COG4106	trans-aconitate 2-methyltransferase activity
BFW77_RS10000	COG0156	8-amino-7-oxononanoate synthase activity
BFW77_RS10070	COG1131	(ABC) transporter
BFW77_RS10075	COG0842	Transport permease protein
BFW77_RS10080	COG0628	permease
BFW77_RS10115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BFW77_RS10125	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BFW77_RS10130	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BFW77_RS10135	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BFW77_RS10140	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BFW77_RS10145	COG0330	HflC and HflK could
BFW77_RS10150	COG0330	HflC and HflK could
BFW77_RS10155	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BFW77_RS10160	COG1923	regulation of RNA biosynthetic process
BFW77_RS10165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BFW77_RS10170	COG1160	GTP binding
BFW77_RS10175	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BFW77_RS10180	COG2976	Protein conserved in bacteria
BFW77_RS10185	COG0124	histidyl-tRNA synthetase
BFW77_RS10190	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BFW77_RS10200	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BFW77_RS10205	COG0105	UTP biosynthetic process
BFW77_RS10210	COG0525	valine-tRNA ligase activity
BFW77_RS10225	COG0642	Histidine kinase
BFW77_RS10250	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BFW77_RS10255	COG0336	Belongs to the RNA methyltransferase TrmD family
BFW77_RS10260	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BFW77_RS10265	COG0228	four-way junction DNA binding
BFW77_RS10275	COG0425	Belongs to the sulfur carrier protein TusA family
BFW77_RS10280	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BFW77_RS10325	COG0154	amidase activity
BFW77_RS10330	COG4172	Belongs to the ABC transporter superfamily
BFW77_RS10335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BFW77_RS10340	COG0601	transmembrane transport
BFW77_RS10345	COG0747	negative chemotaxis
BFW77_RS10370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BFW77_RS10380	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BFW77_RS10395	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BFW77_RS10400	COG3395	kinase activity
BFW77_RS10415	COG1024	Enoyl-CoA hydratase
BFW77_RS10435	COG0633	Ferredoxin
BFW77_RS10440	COG0443	Heat shock 70 kDa protein
BFW77_RS10445	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BFW77_RS10450	COG0316	Belongs to the HesB IscA family
BFW77_RS10455	COG0822	iron-sulfur transferase activity
BFW77_RS10460	COG1104	cysteine desulfurase activity
BFW77_RS10470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BFW77_RS10475	COG0556	nucleotide-excision repair
BFW77_RS10485	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BFW77_RS10490	COG3468	outer membrane autotransporter barrel domain protein
BFW77_RS10515	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BFW77_RS10530	COG1960	acyl-CoA dehydrogenase activity
BFW77_RS10535	COG1028	Short-chain dehydrogenase reductase Sdr
BFW77_RS10540	COG0183	Belongs to the thiolase family
BFW77_RS10550	COG1024	Enoyl-CoA hydratase
BFW77_RS10565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BFW77_RS10570	COG0583	DNA-binding transcription factor activity
BFW77_RS10575	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BFW77_RS10580	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BFW77_RS10585	COG0740	serine-type endopeptidase activity
BFW77_RS10590	COG0544	peptidyl-prolyl cis-trans isomerase activity
BFW77_RS10610	COG1278	Cold shock
BFW77_RS10645	COG2171	N-acyltransferase activity
BFW77_RS10650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BFW77_RS10655	COG2890	protein-(glutamine-N5) methyltransferase activity
BFW77_RS10660	COG0488	(ABC) transporter
BFW77_RS10665	COG4771	TonB-dependent receptor
BFW77_RS10670	COG0210	DNA helicase
BFW77_RS10690	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BFW77_RS10695	COG0196	riboflavin kinase activity
BFW77_RS10700	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BFW77_RS10705	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BFW77_RS10710	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BFW77_RS10720	COG1522	sequence-specific DNA binding
BFW77_RS10740	COG2951	lytic endotransglycosylase activity
BFW77_RS10745	COG2833	Protein of unknown function (DUF455)
BFW77_RS10765	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BFW77_RS10765	COG0189	ligase activity
BFW77_RS10770	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BFW77_RS10770	COG1181	Belongs to the D-alanine--D-alanine ligase family
BFW77_RS10775	COG3237	CsbD-like
BFW77_RS10785	COG2823	Periplasmic or secreted lipoprotein
BFW77_RS10800	COG4181	ATPase activity
BFW77_RS10810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BFW77_RS10815	COG0584	glycerophosphoryl diester phosphodiesterase
BFW77_RS10820	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BFW77_RS10830	COG0678	peroxiredoxin activity
BFW77_RS10830	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BFW77_RS10840	COG0789	Transcriptional regulator
BFW77_RS10845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BFW77_RS10875	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BFW77_RS10880	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BFW77_RS10890	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BFW77_RS10895	COG2252	PERMEase
BFW77_RS10905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BFW77_RS10935	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BFW77_RS10940	COG2358	TRAP transporter, solute receptor (TAXI family
BFW77_RS10970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BFW77_RS10975	COG1366	Belongs to the anti-sigma-factor antagonist family
BFW77_RS10980	COG2172	sigma factor antagonist activity
BFW77_RS10985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BFW77_RS10995	COG2770	Histidine kinase
BFW77_RS10995	COG2208	phosphoserine phosphatase activity
BFW77_RS11020	COG1595	DNA-templated transcription, initiation
BFW77_RS11035	COG4792	protein secretion
BFW77_RS11040	COG4791	protein targeting
BFW77_RS11045	COG4794	Type iii secretion
BFW77_RS11050	COG4790	Type iii secretion
BFW77_RS11085	COG4669	(LipO)protein
BFW77_RS11150	COG4789	Type iii secretion
BFW77_RS11180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BFW77_RS11185	COG0840	transmembrane signaling receptor activity
BFW77_RS11190	COG2233	PERMEase
BFW77_RS11210	COG0492	ferredoxin-NADP+ reductase activity
BFW77_RS11215	COG1840	ABC-type Fe3 transport system, periplasmic component
BFW77_RS11220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BFW77_RS11225	COG1178	ABC-type Fe3 transport system permease component
BFW77_RS11230	COG3842	ATPase activity
BFW77_RS11235	COG0583	DNA-binding transcription factor activity
BFW77_RS11255	COG0501	Belongs to the peptidase M48B family
BFW77_RS11265	COG0697	spore germination
BFW77_RS11275	COG1846	Transcriptional regulator
BFW77_RS11285	COG1566	PFAM secretion protein HlyD family protein
BFW77_RS11290	COG2814	Major facilitator Superfamily
BFW77_RS11295	COG0473	3-isopropylmalate dehydrogenase activity
BFW77_RS11305	COG0747	negative chemotaxis
BFW77_RS11315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BFW77_RS11330	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BFW77_RS11355	COG1012	belongs to the aldehyde dehydrogenase family
BFW77_RS11365	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BFW77_RS11370	COG1115	amino acid carrier protein
BFW77_RS11375	COG0433	COG0433 Predicted ATPase
BFW77_RS11380	COG0217	transcriptional regulatory protein
BFW77_RS11385	COG0151	Belongs to the GarS family
BFW77_RS11390	COG0408	coproporphyrinogen oxidase activity
BFW77_RS11395	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BFW77_RS11400	COG0799	negative regulation of ribosome biogenesis
BFW77_RS11405	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BFW77_RS11410	COG0424	maF-like protein
BFW77_RS11415	COG3468	outer membrane autotransporter barrel domain protein
BFW77_RS11455	COG1530	ribonuclease E activity
BFW77_RS11460	COG0077	Prephenate dehydratase
BFW77_RS11475	COG1132	(ABC) transporter
BFW77_RS11480	COG0859	PFAM glycosyl transferase family 9
BFW77_RS11505	COG2194	sulfuric ester hydrolase activity
BFW77_RS11510	COG0438	transferase activity, transferring glycosyl groups
BFW77_RS11515	COG0463	Glycosyl transferase, family 2
BFW77_RS11520	COG0726	polysaccharide deacetylase
BFW77_RS11525	COG0438	transferase activity, transferring glycosyl groups
BFW77_RS11540	COG1643	Atp-dependent helicase
BFW77_RS11545	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BFW77_RS11545	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BFW77_RS11550	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BFW77_RS11560	COG0704	Plays a role in the regulation of phosphate uptake
BFW77_RS11565	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BFW77_RS11570	COG1960	acyl-CoA dehydrogenase activity
BFW77_RS11595	COG1177	transmembrane transport
BFW77_RS11600	COG1176	ABC-type spermidine putrescine transport system, permease component I
BFW77_RS11605	COG3842	ATPase activity
BFW77_RS11610	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BFW77_RS11625	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BFW77_RS11630	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BFW77_RS11640	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BFW77_RS11640	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BFW77_RS11655	COG0372	Belongs to the citrate synthase family
BFW77_RS11660	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BFW77_RS11665	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BFW77_RS11670	COG1053	succinate dehydrogenase
BFW77_RS11675	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BFW77_RS11680	COG2009	succinate dehydrogenase
BFW77_RS11685	COG2188	Transcriptional regulator
BFW77_RS11690	COG0039	L-malate dehydrogenase activity
BFW77_RS11720	COG1981	membrane
BFW77_RS11745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BFW77_RS11755	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BFW77_RS11785	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BFW77_RS11790	COG0148	phosphopyruvate hydratase activity
BFW77_RS11800	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BFW77_RS11805	COG0504	CTP synthase activity
BFW77_RS11830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BFW77_RS11840	COG0747	negative chemotaxis
BFW77_RS11845	COG4172	Belongs to the ABC transporter superfamily
BFW77_RS11850	COG1446	asparaginase
BFW77_RS11880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BFW77_RS11895	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
BFW77_RS11900	COG0697	spore germination
BFW77_RS11905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BFW77_RS11915	COG3193	protein, possibly involved in utilization of glycolate and propanediol
BFW77_RS11925	COG0791	NLP P60 protein
BFW77_RS11940	COG0583	DNA-binding transcription factor activity
BFW77_RS11955	COG0583	DNA-binding transcription factor activity
BFW77_RS11965	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BFW77_RS11980	COG0670	Belongs to the BI1 family
BFW77_RS11985	COG3181	Tripartite tricarboxylate transporter family receptor
BFW77_RS12000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BFW77_RS12010	COG1381	Involved in DNA repair and RecF pathway recombination
BFW77_RS12015	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BFW77_RS12020	COG0571	ribonuclease III activity
BFW77_RS12025	COG0681	Belongs to the peptidase S26 family
BFW77_RS12030	COG0481	GTPase activity
BFW77_RS12035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFW77_RS12060	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BFW77_RS12065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BFW77_RS12080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BFW77_RS12085	COG0416	fatty acid biosynthetic process
BFW77_RS12090	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BFW77_RS12095	COG1399	metal-binding, possibly nucleic acid-binding protein
BFW77_RS12100	COG0424	maF-like protein
BFW77_RS12110	COG3023	N-Acetylmuramoyl-L-alanine amidase
BFW77_RS12115	COG1289	transmembrane transporter activity
BFW77_RS12125	COG3022	response to hydroperoxide
BFW77_RS12140	COG0135	phosphoribosylanthranilate isomerase activity
BFW77_RS12155	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BFW77_RS12160	COG0101	tRNA pseudouridine synthase activity
BFW77_RS12170	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BFW77_RS12175	COG0473	3-isopropylmalate dehydrogenase activity
BFW77_RS12180	COG0066	3-isopropylmalate dehydratase activity
BFW77_RS12185	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BFW77_RS12195	COG1122	ATPase activity
BFW77_RS12225	COG0437	4 iron, 4 sulfur cluster binding
BFW77_RS12230	COG0243	molybdopterin cofactor binding
BFW77_RS12230	COG3383	formate dehydrogenase (NAD+) activity
BFW77_RS12260	COG0489	protein tyrosine kinase activity
BFW77_RS12265	COG0746	molybdenum cofactor guanylyltransferase activity
BFW77_RS12270	COG0303	'Molybdopterin
BFW77_RS12275	COG1763	Mo-molybdopterin cofactor biosynthetic process
BFW77_RS12285	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BFW77_RS12290	COG5001	Diguanylate cyclase
BFW77_RS12310	COG3842	ATPase activity
BFW77_RS12320	COG0406	alpha-ribazole phosphatase activity
BFW77_RS12330	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BFW77_RS12335	COG0505	Belongs to the CarA family
BFW77_RS12340	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BFW77_RS12375	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BFW77_RS12380	COG1960	acyl-CoA dehydrogenase activity
BFW77_RS12390	COG2867	negative regulation of translational initiation
BFW77_RS12400	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BFW77_RS12405	COG3706	GGDEF domain
BFW77_RS12410	COG0330	HflC and HflK could
BFW77_RS12425	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BFW77_RS12425	COG0519	Catalyzes the synthesis of GMP from XMP
BFW77_RS12435	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BFW77_RS12440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BFW77_RS12445	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BFW77_RS12450	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BFW77_RS12460	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BFW77_RS12465	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BFW77_RS12470	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
BFW77_RS12475	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BFW77_RS12480	COG0750	zinc metalloprotease
BFW77_RS12485	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BFW77_RS12495	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BFW77_RS12500	COG0233	cytoplasmic translational termination
BFW77_RS12505	COG0528	UMP kinase activity
BFW77_RS12510	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BFW77_RS12515	COG0052	Belongs to the universal ribosomal protein uS2 family
BFW77_RS12520	COG0024	Methionine aminopeptidase
BFW77_RS12525	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BFW77_RS12555	COG0285	dihydrofolate synthase activity
BFW77_RS12590	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BFW77_RS12600	COG1677	Flagellar hook-basal body complex protein FliE
BFW77_RS12610	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BFW77_RS12620	COG1157	protein secretion by the type III secretion system
BFW77_RS12645	COG1580	Controls the rotational direction of flagella during chemotaxis
BFW77_RS12665	COG1338	Plays a role in the flagellum-specific transport system
BFW77_RS12685	COG0840	transmembrane signaling receptor activity
BFW77_RS12690	COG0840	transmembrane signaling receptor activity
BFW77_RS12695	COG0840	transmembrane signaling receptor activity
BFW77_RS12705	COG1256	bacterial-type flagellum assembly
BFW77_RS12715	COG1706	bacterial-type flagellum-dependent cell motility
BFW77_RS12720	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
BFW77_RS12735	COG1749	Flagellar hook protein flgE
BFW77_RS12745	COG1558	bacterial-type flagellum-dependent cell motility
BFW77_RS12750	COG1815	bacterial-type flagellum-dependent cell motility
BFW77_RS12790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BFW77_RS12795	COG0765	amino acid transport
BFW77_RS12800	COG1126	abc transporter atp-binding protein
BFW77_RS12815	COG4948	Mandelate Racemase Muconate Lactonizing
BFW77_RS12820	COG3181	Tripartite tricarboxylate transporter family receptor
BFW77_RS12830	COG0066	3-isopropylmalate dehydratase activity
BFW77_RS12845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BFW77_RS12855	COG3181	Tripartite tricarboxylate transporter family receptor
BFW77_RS12865	COG1802	Transcriptional regulator
BFW77_RS12880	COG0583	DNA-binding transcription factor activity
BFW77_RS12900	COG1695	Transcriptional regulator
BFW77_RS12910	COG3568	Endonuclease Exonuclease Phosphatase
BFW77_RS12915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BFW77_RS12930	COG0392	lysyltransferase activity
BFW77_RS12965	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BFW77_RS12975	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BFW77_RS12995	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BFW77_RS13025	COG0667	Aldo Keto reductase
BFW77_RS13040	COG2259	Doxx family
BFW77_RS13070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BFW77_RS13090	COG0386	Belongs to the glutathione peroxidase family
BFW77_RS13095	COG0625	glutathione transferase activity
BFW77_RS13110	COG0095	Lipoate-protein ligase
BFW77_RS13125	COG0688	phosphatidylethanolamine metabolic process
BFW77_RS13135	COG1464	Belongs to the NlpA lipoprotein family
BFW77_RS13150	COG2363	Small membrane protein
BFW77_RS13175	COG3842	ATPase activity
BFW77_RS13180	COG0395	ABC-type sugar transport system, permease component
BFW77_RS13185	COG1175	transmembrane transport
BFW77_RS13190	COG1653	transport
BFW77_RS13200	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BFW77_RS13215	COG0559	Belongs to the binding-protein-dependent transport system permease family
BFW77_RS13235	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BFW77_RS13250	COG0697	spore germination
BFW77_RS13260	COG2311	Membrane
BFW77_RS13285	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BFW77_RS13295	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BFW77_RS13300	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BFW77_RS13305	COG1760	l-serine dehydratase
BFW77_RS13310	COG1283	sodium-dependent phosphate transmembrane transporter activity
BFW77_RS13315	COG0412	Dienelactone hydrolase
BFW77_RS13330	COG1611	Belongs to the LOG family
BFW77_RS13350	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BFW77_RS13355	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BFW77_RS13360	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BFW77_RS13365	COG2251	uridine kinase activity
BFW77_RS13365	COG0195	Participates in both transcription termination and antitermination
BFW77_RS13370	COG0779	Required for maturation of 30S ribosomal subunits
BFW77_RS13375	COG1187	pseudouridine synthase activity
BFW77_RS13380	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BFW77_RS13390	COG0583	DNA-binding transcription factor activity
BFW77_RS13400	COG0523	cobalamin synthesis protein
BFW77_RS13420	COG0625	glutathione transferase activity
BFW77_RS13425	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BFW77_RS13430	COG1047	Peptidyl-prolyl cis-trans
BFW77_RS13435	COG2003	Belongs to the UPF0758 family
BFW77_RS13440	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BFW77_RS13445	COG3483	tryptophan 2,3-dioxygenase activity
BFW77_RS13450	COG0254	rRNA binding
BFW77_RS13460	COG0534	Mate efflux family protein
BFW77_RS13480	COG2304	oxidoreductase activity
BFW77_RS13500	COG1028	Short-chain dehydrogenase reductase Sdr
BFW77_RS13505	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BFW77_RS13510	COG1562	ergosterol biosynthetic process
BFW77_RS13515	COG1562	ergosterol biosynthetic process
BFW77_RS13520	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
BFW77_RS13520	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
BFW77_RS13525	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BFW77_RS13535	COG0842	Transport permease protein
BFW77_RS13540	COG1131	(ABC) transporter
BFW77_RS13560	COG1477	protein flavinylation
BFW77_RS13575	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
BFW77_RS13590	COG5564	TIM-barrel signal transduction protein
BFW77_RS13595	COG5441	Belongs to the UPF0261 family
BFW77_RS13605	COG3468	outer membrane autotransporter barrel domain protein
BFW77_RS13610	COG3468	outer membrane autotransporter barrel domain protein
BFW77_RS13625	COG0542	response to heat
BFW77_RS13630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BFW77_RS13645	COG0494	nUDIX hydrolase
BFW77_RS13650	COG3530	Putative quorum-sensing-regulated virulence factor
BFW77_RS13660	COG1595	DNA-templated transcription, initiation
BFW77_RS13665	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BFW77_RS13700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BFW77_RS13705	COG0765	amino acid transport
BFW77_RS13710	COG0765	amino acid transport
BFW77_RS13740	COG2988	succinylglutamate desuccinylase activity
BFW77_RS13765	COG3181	Tripartite tricarboxylate transporter family receptor
BFW77_RS13770	COG2084	Dehydrogenase
BFW77_RS13785	COG1619	proteins homologs of microcin C7 resistance protein MccF
BFW77_RS13800	COG2814	Major facilitator Superfamily
BFW77_RS13810	COG0583	DNA-binding transcription factor activity
BFW77_RS13850	COG0672	)-iron permease
BFW77_RS13865	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
BFW77_RS13870	COG1028	Short-chain dehydrogenase reductase Sdr
BFW77_RS13875	COG3243	poly(R)-hydroxyalkanoic acid synthase
BFW77_RS13885	COG0564	pseudouridine synthase activity
BFW77_RS13895	COG1199	ATP-dependent helicase activity
BFW77_RS13900	COG2183	response to ionizing radiation
BFW77_RS13905	COG0180	Tryptophanyl-tRNA synthetase
BFW77_RS13930	COG3181	Tripartite tricarboxylate transporter family receptor
BFW77_RS13940	COG0583	DNA-binding transcription factor activity
BFW77_RS13945	COG1028	Short-chain dehydrogenase reductase Sdr
BFW77_RS13950	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BFW77_RS13955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BFW77_RS13960	COG0508	dehydrogenase complex catalyzes the overall conversion of
BFW77_RS13965	COG0567	Dehydrogenase, E1 component
BFW77_RS13975	COG1522	sequence-specific DNA binding
BFW77_RS13985	COG0281	malic enzyme
BFW77_RS13985	COG0280	phosphate acetyltransferase
BFW77_RS13990	COG3539	Fimbrial protein
BFW77_RS14010	COG0613	PHP domain protein
BFW77_RS14020	COG0658	competence protein
BFW77_RS14020	COG2333	competence protein COMEC
BFW77_RS14050	COG0084	hydrolase, TatD family'
BFW77_RS14055	COG1136	(ABC) transporter
BFW77_RS14070	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BFW77_RS14080	COG1028	Short-chain dehydrogenase reductase Sdr
BFW77_RS14085	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BFW77_RS14100	COG1022	Amp-dependent synthetase and ligase
BFW77_RS14135	COG2205	protein histidine kinase activity
BFW77_RS14140	COG0745	RESPONSE REGULATOR receiver
BFW77_RS14145	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BFW77_RS14155	COG1295	ribonuclease BN
BFW77_RS14170	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BFW77_RS14200	COG1534	Rna-binding protein
BFW77_RS14205	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BFW77_RS14210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BFW77_RS14220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BFW77_RS14230	COG0248	Ppx GppA phosphatase
BFW77_RS14255	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BFW77_RS14270	COG2732	(Barnase) inhibitor
BFW77_RS14280	COG0281	malic enzyme
BFW77_RS14280	COG0280	phosphate acetyltransferase
BFW77_RS14290	COG0436	Aminotransferase
BFW77_RS14295	COG0741	lytic transglycosylase activity
BFW77_RS14300	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BFW77_RS14325	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BFW77_RS14325	COG1648	precorrin-2 dehydrogenase activity
BFW77_RS14330	COG3468	outer membrane autotransporter barrel domain protein
BFW77_RS14340	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BFW77_RS14345	COG2027	D-alanyl-D-alanine carboxypeptidase
BFW77_RS14350	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BFW77_RS14355	COG0343	queuine tRNA-ribosyltransferase activity
BFW77_RS14360	COG1862	Preprotein translocase
BFW77_RS14365	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BFW77_RS14370	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BFW77_RS14385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BFW77_RS14390	COG1702	phosphate starvation-inducible protein PhoH
BFW77_RS14395	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BFW77_RS14400	COG4535	Mg2 and Co2 transporter CorC
BFW77_RS14410	COG0667	Aldo Keto reductase
BFW77_RS14435	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
BFW77_RS14440	COG0745	RESPONSE REGULATOR receiver
BFW77_RS14445	COG2201	protein-glutamate methylesterase activity
BFW77_RS14455	COG0840	transmembrane signaling receptor activity
BFW77_RS14470	COG0745	RESPONSE REGULATOR receiver
BFW77_RS14505	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BFW77_RS14515	COG0739	heme binding
BFW77_RS14525	COG0521	Mo-molybdopterin cofactor biosynthetic process
BFW77_RS14535	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BFW77_RS14570	COG0625	glutathione transferase activity
BFW77_RS14585	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BFW77_RS14590	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BFW77_RS14595	COG0126	phosphoglycerate kinase activity
BFW77_RS14600	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BFW77_RS14605	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BFW77_RS14610	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BFW77_RS14620	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BFW77_RS14625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BFW77_RS14630	COG0508	dehydrogenase complex catalyzes the overall conversion of
BFW77_RS14635	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BFW77_RS14645	COG4566	intracellular signal transduction
BFW77_RS14650	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BFW77_RS14655	COG0339	signal peptide processing
BFW77_RS14660	COG1999	signal sequence binding
BFW77_RS14680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BFW77_RS14690	COG1187	pseudouridine synthase activity
BFW77_RS14695	COG3161	chorismate lyase activity
BFW77_RS14700	COG2814	Major facilitator Superfamily
BFW77_RS14710	COG0667	Aldo Keto reductase
BFW77_RS14725	COG0335	large ribosomal subunit rRNA binding
BFW77_RS14755	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BFW77_RS14775	COG0450	alkyl hydroperoxide reductase
BFW77_RS14780	COG1960	acyl-CoA dehydrogenase activity
BFW77_RS14795	COG0123	including yeast histone deacetylase and acetoin utilization protein
BFW77_RS14800	COG2951	lytic endotransglycosylase activity
BFW77_RS14815	COG1596	polysaccharide export
BFW77_RS14815	COG1555	photosystem II stabilization
BFW77_RS14820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BFW77_RS14825	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BFW77_RS14830	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BFW77_RS14850	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BFW77_RS14855	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BFW77_RS14860	COG0287	Prephenate dehydrogenase
BFW77_RS14870	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BFW77_RS14885	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BFW77_RS14895	COG2814	Major facilitator Superfamily
BFW77_RS14920	COG0583	DNA-binding transcription factor activity
BFW77_RS14960	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BFW77_RS14975	COG0667	Aldo Keto reductase
BFW77_RS14985	COG5265	(ABC) transporter
BFW77_RS15030	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BFW77_RS15035	COG0439	Biotin carboxylase
BFW77_RS15040	COG2188	Transcriptional regulator
BFW77_RS15065	COG0511	ligase activity, forming carbon-carbon bonds
BFW77_RS15075	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BFW77_RS15095	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
BFW77_RS15115	COG0500	methyltransferase
BFW77_RS15120	COG5265	(ABC) transporter
BFW77_RS15135	COG0028	Belongs to the TPP enzyme family
BFW77_RS15140	COG0440	acetolactate synthase activity
BFW77_RS15145	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BFW77_RS15150	COG1183	phosphatidylcholine synthase activity
BFW77_RS15165	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BFW77_RS15170	COG1185	polyribonucleotide nucleotidyltransferase activity
BFW77_RS15185	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BFW77_RS15205	COG0149	triose-phosphate isomerase activity
BFW77_RS15210	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BFW77_RS15220	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BFW77_RS15230	COG3799	methylaspartate ammonia-lyase activity
BFW77_RS15265	COG0583	DNA-binding transcription factor activity
BFW77_RS15270	COG0626	cystathionine gamma-synthase activity
BFW77_RS15275	COG3608	succinylglutamate desuccinylase aspartoacylase
BFW77_RS15295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BFW77_RS15315	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
BFW77_RS15330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BFW77_RS15335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BFW77_RS15340	COG1733	regulation of RNA biosynthetic process
BFW77_RS15350	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BFW77_RS15355	COG0583	DNA-binding transcription factor activity
BFW77_RS15360	COG1597	lipid kinase activity
BFW77_RS15370	COG0671	phosphoesterase, PA-phosphatase related
BFW77_RS15400	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BFW77_RS15405	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BFW77_RS15410	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BFW77_RS15415	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BFW77_RS15420	COG0649	NAD binding
BFW77_RS15425	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BFW77_RS15435	COG1034	ATP synthesis coupled electron transport
BFW77_RS15440	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BFW77_RS15445	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BFW77_RS15455	COG0713	ATP synthesis coupled electron transport
BFW77_RS15470	COG1007	ATP synthesis coupled electron transport
BFW77_RS15480	COG4774	siderophore transport
BFW77_RS15485	COG4774	siderophore transport
BFW77_RS15500	COG0028	Belongs to the TPP enzyme family
BFW77_RS15505	COG3181	Tripartite tricarboxylate transporter family receptor
BFW77_RS15510	COG0583	DNA-binding transcription factor activity
BFW77_RS15515	COG0560	Phosphoserine phosphatase
BFW77_RS15520	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BFW77_RS15525	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BFW77_RS15530	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BFW77_RS15545	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BFW77_RS15550	COG0308	aminopeptidase N
BFW77_RS15570	COG0028	Belongs to the TPP enzyme family
BFW77_RS15590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BFW77_RS15600	COG0318	PFAM AMP-dependent synthetase and ligase
BFW77_RS15610	COG1802	Transcriptional regulator
BFW77_RS15620	COG1802	Transcriptional regulator
BFW77_RS15630	COG1028	Short-chain dehydrogenase reductase Sdr
BFW77_RS15650	COG1126	abc transporter atp-binding protein
BFW77_RS15655	COG0765	amino acid transport
BFW77_RS15660	COG0765	amino acid transport
BFW77_RS15675	COG1538	Outer membrane efflux protein
BFW77_RS15680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BFW77_RS15685	COG2274	protein secretion by the type I secretion system
BFW77_RS15690	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
BFW77_RS15700	COG2994	toxin metabolic process
BFW77_RS15715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BFW77_RS15720	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
BFW77_RS15730	COG0583	DNA-binding transcription factor activity
BFW77_RS15740	COG0142	geranyltranstransferase activity
BFW77_RS15750	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BFW77_RS15755	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BFW77_RS15760	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BFW77_RS15765	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BFW77_RS15810	COG3712	iron ion homeostasis
BFW77_RS15815	COG4774	siderophore transport
BFW77_RS15820	COG2353	YceI-like domain
BFW77_RS15835	COG0019	diaminopimelate decarboxylase activity
BFW77_RS15855	COG0747	negative chemotaxis
BFW77_RS15860	COG0601	transmembrane transport
BFW77_RS15865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BFW77_RS15875	COG0154	amidase activity
BFW77_RS15880	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BFW77_RS15905	COG2154	pterin-4-alpha-carbinolamine dehydratase
BFW77_RS15915	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BFW77_RS15925	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BFW77_RS15930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BFW77_RS15935	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BFW77_RS15940	COG1929	Belongs to the glycerate kinase type-1 family
BFW77_RS15945	COG0469	pyruvate kinase activity
BFW77_RS15950	COG0700	Nucleoside recognition
BFW77_RS15985	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BFW77_RS15990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BFW77_RS16005	COG0823	Involved in the tonB-independent uptake of proteins
BFW77_RS16015	COG0848	biopolymer transport protein
BFW77_RS16020	COG0811	peptide transport
BFW77_RS16025	COG0824	Thioesterase
BFW77_RS16030	COG0442	prolyl-tRNA aminoacylation
BFW77_RS16035	COG0494	nUDIX hydrolase
BFW77_RS16050	COG2135	peptidase activity
BFW77_RS16120	COG1196	nuclear chromosome segregation
BFW77_RS16265	COG1464	Belongs to the NlpA lipoprotein family
BFW77_RS16295	COG4211	Belongs to the binding-protein-dependent transport system permease family
BFW77_RS16305	COG0154	amidase activity
BFW77_RS16310	COG0288	reversible hydration of carbon dioxide
BFW77_RS16325	COG0514	ATP-dependent DNA helicase (RecQ)
BFW77_RS16330	COG2255	four-way junction helicase activity
BFW77_RS16345	COG0632	four-way junction helicase activity
BFW77_RS16350	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BFW77_RS16370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BFW77_RS16380	COG0006	proline dipeptidase activity
BFW77_RS16405	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BFW77_RS16420	COG4783	chaperone-mediated protein folding
BFW77_RS16425	COG0429	hydrolase of the alpha beta-hydrolase fold
BFW77_RS16455	COG0513	Belongs to the DEAD box helicase family
BFW77_RS16475	COG1058	Belongs to the CinA family
BFW77_RS16475	COG1546	Belongs to the CinA family
BFW77_RS16480	COG1414	Transcriptional regulator
BFW77_RS16500	COG0167	dihydroorotate dehydrogenase activity
BFW77_RS16505	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BFW77_RS16510	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BFW77_RS16520	COG0583	DNA-binding transcription factor activity
BFW77_RS16580	COG0281	malic enzyme
BFW77_RS16580	COG0280	phosphate acetyltransferase
BFW77_RS16590	COG0601	transmembrane transport
BFW77_RS16595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BFW77_RS16600	COG4172	Belongs to the ABC transporter superfamily
BFW77_RS16630	COG0640	Transcriptional regulator
BFW77_RS16645	COG3135	benzoate transporter
BFW77_RS16650	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BFW77_RS16655	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BFW77_RS16660	COG0742	ribosomal rna small subunit methyltransferase
BFW77_RS16675	COG3639	organic phosphonate transmembrane transporter activity
BFW77_RS16680	COG3639	organic phosphonate transmembrane transporter activity
BFW77_RS16685	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BFW77_RS16720	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BFW77_RS16725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BFW77_RS16735	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BFW77_RS16740	COG1058	Belongs to the CinA family
BFW77_RS16740	COG1546	Belongs to the CinA family
BFW77_RS16745	COG0284	orotidine-5'-phosphate decarboxylase activity
BFW77_RS16750	COG1252	NADH dehydrogenase
BFW77_RS16765	COG3468	outer membrane autotransporter barrel domain protein
BFW77_RS16770	COG0459	protein refolding
BFW77_RS16775	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BFW77_RS16795	COG1053	succinate dehydrogenase
BFW77_RS16805	COG0583	DNA-binding transcription factor activity
BFW77_RS16810	COG1053	succinate dehydrogenase
BFW77_RS16835	COG3706	GGDEF domain
BFW77_RS16870	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BFW77_RS16875	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BFW77_RS16885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BFW77_RS16895	COG0069	glutamate synthase activity
BFW77_RS16900	COG2391	methyltransferase activity
BFW77_RS16905	COG0679	Auxin Efflux Carrier
BFW77_RS16930	COG0557	exoribonuclease II activity
BFW77_RS16935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BFW77_RS16945	COG3128	pkhd-type hydroxylase
BFW77_RS16950	COG0776	regulation of translation
BFW77_RS16980	COG0642	Histidine kinase
BFW77_RS16985	COG3158	transport of potassium into the cell
BFW77_RS16990	COG0137	argininosuccinate synthase activity
BFW77_RS16995	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BFW77_RS17000	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BFW77_RS17010	COG0583	DNA-binding transcription factor activity
BFW77_RS17020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BFW77_RS17040	COG2186	Transcriptional regulator
BFW77_RS17050	COG2223	nitrite transmembrane transporter activity
BFW77_RS17060	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BFW77_RS17065	COG0450	alkyl hydroperoxide reductase
BFW77_RS17085	COG1214	PFAM Peptidase M22, glycoprotease
BFW77_RS17090	COG1573	uracil-dna glycosylase
BFW77_RS17095	COG0477	Major facilitator Superfamily
BFW77_RS17100	COG1196	nuclear chromosome segregation
BFW77_RS17110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BFW77_RS17115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BFW77_RS17130	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BFW77_RS17135	COG1122	ATPase activity
BFW77_RS17140	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BFW77_RS17145	COG1268	BioY protein
BFW77_RS17165	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BFW77_RS17200	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BFW77_RS17205	COG2878	Part of a membrane complex involved in electron transport
BFW77_RS17220	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BFW77_RS17225	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BFW77_RS17230	COG0251	oxidation-reduction process
BFW77_RS17240	COG3228	Belongs to the MtfA family
BFW77_RS17245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BFW77_RS17255	COG0133	tryptophan synthase activity
BFW77_RS17260	COG0159	tryptophan synthase activity
BFW77_RS17265	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BFW77_RS17270	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BFW77_RS17285	COG1530	ribonuclease E activity
BFW77_RS17295	COG0546	phosphoglycolate phosphatase activity
BFW77_RS17300	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BFW77_RS17305	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
BFW77_RS17315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BFW77_RS17320	COG0583	DNA-binding transcription factor activity
BFW77_RS17330	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BFW77_RS17350	COG0251	oxidation-reduction process
BFW77_RS17355	COG1017	nitric oxide dioxygenase activity
BFW77_RS17355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BFW77_RS17360	COG2031	fatty acid transporter
BFW77_RS17365	COG1012	belongs to the aldehyde dehydrogenase family
BFW77_RS17370	COG1802	Transcriptional regulator
BFW77_RS17380	COG1278	Cold shock
BFW77_RS17385	COG0583	DNA-binding transcription factor activity
BFW77_RS17410	COG0183	Belongs to the thiolase family
BFW77_RS17420	COG1960	acyl-CoA dehydrogenase activity
BFW77_RS17425	COG0583	DNA-binding transcription factor activity
BFW77_RS17430	COG3181	Tripartite tricarboxylate transporter family receptor
BFW77_RS17435	COG1024	Enoyl-CoA hydratase
BFW77_RS17440	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BFW77_RS17445	COG1253	flavin adenine dinucleotide binding
BFW77_RS17450	COG1285	pathogenesis
BFW77_RS17460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BFW77_RS17475	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BFW77_RS17485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BFW77_RS17495	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BFW77_RS17500	COG3181	Tripartite tricarboxylate transporter family receptor
BFW77_RS17505	COG1960	acyl-CoA dehydrogenase activity
BFW77_RS17525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BFW77_RS17530	COG1024	Enoyl-CoA hydratase
BFW77_RS17535	COG1960	acyl-CoA dehydrogenase activity
BFW77_RS17555	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BFW77_RS17560	COG0022	dehydrogenase e1 component
BFW77_RS17565	COG1024	Enoyl-CoA hydratase
BFW77_RS17570	COG0508	dehydrogenase complex catalyzes the overall conversion of
BFW77_RS17590	COG0683	leucine binding
BFW77_RS17595	COG0559	Belongs to the binding-protein-dependent transport system permease family
BFW77_RS17600	COG0411	ABC transporter
BFW77_RS17610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BFW77_RS17625	COG3181	Tripartite tricarboxylate transporter family receptor
BFW77_RS17650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BFW77_RS17655	COG0793	Belongs to the peptidase S41A family
BFW77_RS17660	COG4942	peptidase
BFW77_RS17665	COG0588	phosphoglycerate mutase activity
BFW77_RS17670	COG1054	Belongs to the UPF0176 family
BFW77_RS17675	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BFW77_RS17680	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BFW77_RS17685	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BFW77_RS17690	COG3181	Tripartite tricarboxylate transporter family receptor
BFW77_RS17705	COG2226	methyltransferase
BFW77_RS17710	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BFW77_RS17725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BFW77_RS17730	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BFW77_RS17755	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BFW77_RS17780	COG1335	isochorismatase
BFW77_RS17785	COG2309	aminopeptidase activity
BFW77_RS17790	COG0596	Alpha beta hydrolase
BFW77_RS17795	COG3473	Maleate cis-trans isomerase
BFW77_RS17805	COG2068	MobA-Related Protein
BFW77_RS17830	COG2204	response regulator
BFW77_RS17835	COG5000	phosphorelay sensor kinase activity
BFW77_RS17845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BFW77_RS17845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BFW77_RS17855	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
BFW77_RS17875	COG0583	DNA-binding transcription factor activity
BFW77_RS17890	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BFW77_RS17895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BFW77_RS17900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BFW77_RS17915	COG0758	DNA mediated transformation
BFW77_RS17920	COG1522	sequence-specific DNA binding
BFW77_RS17930	COG0242	peptide deformylase activity
BFW77_RS17945	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BFW77_RS17955	COG0546	phosphoglycolate phosphatase activity
BFW77_RS17975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BFW77_RS17980	COG1942	4-Oxalocrotonate Tautomerase
BFW77_RS17985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BFW77_RS18010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BFW77_RS18030	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BFW77_RS18035	COG1024	Enoyl-CoA hydratase
BFW77_RS18040	COG1414	Transcriptional regulator
BFW77_RS18045	COG0318	PFAM AMP-dependent synthetase and ligase
BFW77_RS18050	COG3181	Tripartite tricarboxylate transporter family receptor
BFW77_RS18080	COG0583	DNA-binding transcription factor activity
BFW77_RS18095	COG3422	double-strand break repair
BFW77_RS18100	COG0330	HflC and HflK could
BFW77_RS18110	COG0251	oxidation-reduction process
BFW77_RS18160	COG3723	Recombinational DNA repair protein, rece pathway
BFW77_RS18195	COG0582	viral genome integration into host DNA
BFW77_RS18220	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BFW77_RS18230	COG0706	membrane insertase activity
BFW77_RS18235	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BFW77_RS18240	COG0594	ribonuclease P activity
BFW77_RS18245	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BFW77_RS18250	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BFW77_RS18265	COG1414	Transcriptional regulator
BFW77_RS18270	COG0154	amidase activity
BFW77_RS18285	COG1304	FMN binding
BFW77_RS18305	COG1960	acyl-CoA dehydrogenase activity
BFW77_RS18325	COG1960	acyl-CoA dehydrogenase activity
BFW77_RS18340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BFW77_RS18355	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BFW77_RS18360	COG3181	Tripartite tricarboxylate transporter family receptor
BFW77_RS18370	COG2358	TRAP transporter, solute receptor (TAXI family
BFW77_RS18380	COG1629	transport
BFW77_RS18385	COG2922	Belongs to the Smg family
BFW77_RS18410	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BFW77_RS18415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BFW77_RS18420	COG1028	Short-chain dehydrogenase reductase Sdr
BFW77_RS18425	COG1012	belongs to the aldehyde dehydrogenase family
BFW77_RS18435	COG0028	Belongs to the TPP enzyme family
BFW77_RS18440	COG1522	sequence-specific DNA binding
BFW77_RS18445	COG3781	membrane
BFW77_RS18455	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BFW77_RS18475	COG4206	TonB-dependent receptor
BFW77_RS18480	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BFW77_RS18485	COG2022	thiamine diphosphate biosynthetic process
BFW77_RS18490	COG0351	phosphomethylpyrimidine kinase
BFW77_RS18495	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BFW77_RS18510	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BFW77_RS18520	COG0628	permease
BFW77_RS18530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BFW77_RS18545	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BFW77_RS18550	COG0049	tRNA binding
BFW77_RS18555	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BFW77_RS18560	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BFW77_RS18565	COG0051	transcription antitermination factor activity, RNA binding
BFW77_RS18570	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BFW77_RS18575	COG0088	Forms part of the polypeptide exit tunnel
BFW77_RS18580	COG0089	rRNA binding
BFW77_RS18585	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BFW77_RS18590	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BFW77_RS18595	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BFW77_RS18600	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BFW77_RS18605	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BFW77_RS18610	COG0255	Belongs to the universal ribosomal protein uL29 family
BFW77_RS18615	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BFW77_RS18635	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BFW77_RS18640	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BFW77_RS18645	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BFW77_RS18650	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BFW77_RS18655	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BFW77_RS18660	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BFW77_RS18665	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BFW77_RS18670	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BFW77_RS18675	COG1841	ribosomal large subunit assembly
BFW77_RS18680	COG0200	Binds to the 23S rRNA
BFW77_RS18685	COG0201	protein transport
BFW77_RS18690	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BFW77_RS18695	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BFW77_RS18700	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BFW77_RS18705	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BFW77_RS18710	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BFW77_RS18715	COG0202	RNA polymerase activity
BFW77_RS18720	COG0203	ribosomal protein L17
BFW77_RS18725	COG0537	adenosine 5'-monophosphoramidase activity
BFW77_RS18730	COG1324	tolerance protein
BFW77_RS18735	COG4232	protein-disulfide reductase activity
BFW77_RS18750	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BFW77_RS18760	COG1333	cytochrome c biogenesis protein
BFW77_RS18765	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BFW77_RS18780	COG1965	Belongs to the frataxin family
BFW77_RS18790	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BFW77_RS18795	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BFW77_RS18800	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BFW77_RS18815	COG2814	Major facilitator Superfamily
BFW77_RS18820	COG0629	single-stranded DNA binding
BFW77_RS18860	COG0402	S-adenosylhomocysteine deaminase activity
BFW77_RS18870	COG0438	transferase activity, transferring glycosyl groups
BFW77_RS18890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BFW77_RS18915	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BFW77_RS18920	COG2186	Transcriptional regulator
BFW77_RS18940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BFW77_RS18945	COG1956	GAF domain-containing protein
BFW77_RS18950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BFW77_RS18965	COG1652	LysM domain
BFW77_RS18980	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BFW77_RS18995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BFW77_RS19025	COG3181	Tripartite tricarboxylate transporter family receptor
BFW77_RS19040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BFW77_RS19055	COG1024	Enoyl-CoA hydratase
BFW77_RS19070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BFW77_RS19075	COG1309	transcriptional regulator
BFW77_RS19080	COG2816	NAD+ diphosphatase activity
BFW77_RS19085	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BFW77_RS19175	COG2814	Major facilitator Superfamily
BFW77_RS19180	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BFW77_RS19200	COG1999	signal sequence binding
BFW77_RS19205	COG0109	protoheme IX farnesyltransferase activity
BFW77_RS19245	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BFW77_RS19265	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BFW77_RS19270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BFW77_RS19280	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BFW77_RS19285	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
BFW77_RS19295	COG0070	glutamate synthase
BFW77_RS19295	COG0069	glutamate synthase activity
BFW77_RS19295	COG0067	glutamate synthase
BFW77_RS19305	COG3047	cAMP biosynthetic process
BFW77_RS19315	COG1127	ABC transporter
BFW77_RS19320	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BFW77_RS19325	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BFW77_RS19330	COG2853	Lipoprotein
BFW77_RS19340	COG1131	(ABC) transporter
BFW77_RS19345	COG0842	Transport permease protein
BFW77_RS19355	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BFW77_RS19360	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BFW77_RS19365	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BFW77_RS19370	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BFW77_RS19375	COG0131	Imidazoleglycerol-phosphate dehydratase
BFW77_RS19380	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BFW77_RS19385	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BFW77_RS19390	COG0107	imidazoleglycerol-phosphate synthase activity
BFW77_RS19395	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BFW77_RS19400	COG0140	phosphoribosyl-ATP diphosphatase activity
BFW77_RS19405	COG0537	adenosine 5'-monophosphoramidase activity
BFW77_RS19410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BFW77_RS19415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BFW77_RS19430	COG3181	Tripartite tricarboxylate transporter family receptor
BFW77_RS19465	COG3702	type iv secretory pathway
BFW77_RS19470	COG3451	type IV secretory pathway VirB4
BFW77_RS19485	COG3736	Type IV secretory pathway, component VirB8
BFW77_RS19490	COG3504	Conjugal transfer protein
BFW77_RS19495	COG2948	multi-organism process
BFW77_RS19500	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
BFW77_RS19510	COG0697	spore germination
BFW77_RS19530	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BFW77_RS19535	COG0747	negative chemotaxis
BFW77_RS19540	COG0601	transmembrane transport
BFW77_RS19545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BFW77_RS19550	COG0444	Belongs to the ABC transporter superfamily
BFW77_RS19560	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BFW77_RS19570	COG0494	nUDIX hydrolase
BFW77_RS19610	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
BFW77_RS19615	COG0237	dephospho-CoA kinase activity
BFW77_RS19620	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BFW77_RS19635	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BFW77_RS19640	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BFW77_RS19650	COG0477	Major facilitator Superfamily
BFW77_RS19655	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BFW77_RS19670	COG1126	abc transporter atp-binding protein
BFW77_RS19675	COG0765	amino acid transport
BFW77_RS19680	COG4597	amino acid ABC transporter
BFW77_RS19685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BFW77_RS19690	COG2884	Cell division ATP-binding protein ftsE
BFW77_RS19695	COG2177	Part of the ABC transporter FtsEX involved in
BFW77_RS19700	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BFW77_RS19710	COG1194	a g-specific adenine glycosylase
BFW77_RS19720	COG2226	methyltransferase
BFW77_RS19735	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BFW77_RS19740	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BFW77_RS19755	COG1024	Enoyl-CoA hydratase
BFW77_RS19775	COG1024	Enoyl-CoA hydratase
BFW77_RS19780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BFW77_RS19785	COG3181	Tripartite tricarboxylate transporter family receptor
BFW77_RS19795	COG0753	catalase activity
BFW77_RS19800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BFW77_RS19805	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BFW77_RS19815	COG2175	clavaminate synthase activity
BFW77_RS19820	COG1473	amidohydrolase
BFW77_RS19825	COG4608	Belongs to the ABC transporter superfamily
BFW77_RS19830	COG0444	Belongs to the ABC transporter superfamily
BFW77_RS19845	COG0747	negative chemotaxis
BFW77_RS19850	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BFW77_RS19885	COG0436	Aminotransferase
BFW77_RS19890	COG1278	Cold shock