locus-tag	class	description
AVS46_RS00005	COG0445	tRNA wobble uridine modification
AVS46_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
AVS46_RS00015	COG1192	Involved in chromosome partitioning
AVS46_RS00025	COG1475	DNA binding
AVS46_RS00030	COG0252	asparaginase activity
AVS46_RS00055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AVS46_RS00065	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AVS46_RS00075	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AVS46_RS00080	COG0081	regulation of translation
AVS46_RS00085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AVS46_RS00090	COG0222	ribosome binding
AVS46_RS00095	COG0085	RNA polymerase activity
AVS46_RS00100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AVS46_RS00140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AVS46_RS00165	COG1024	Enoyl-CoA hydratase
AVS46_RS00185	COG0752	glycyl-tRNA synthetase alpha subunit
AVS46_RS00190	COG0751	glycine-tRNA ligase activity
AVS46_RS00195	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AVS46_RS00200	COG0204	Acyl-transferase
AVS46_RS00215	COG0242	peptide deformylase activity
AVS46_RS00250	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AVS46_RS00255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AVS46_RS00260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AVS46_RS00260	COG2813	Specifically methylates the guanine in position
AVS46_RS00275	COG2223	nitrite transmembrane transporter activity
AVS46_RS00285	COG1794	racemase activity, acting on amino acids and derivatives
AVS46_RS00290	COG1126	abc transporter atp-binding protein
AVS46_RS00295	COG0765	amino acid transport
AVS46_RS00300	COG0765	amino acid transport
AVS46_RS00305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVS46_RS00370	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AVS46_RS00400	COG0326	Molecular chaperone. Has ATPase activity
AVS46_RS00405	COG0625	glutathione transferase activity
AVS46_RS00420	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AVS46_RS00425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AVS46_RS00460	COG0438	transferase activity, transferring glycosyl groups
AVS46_RS00465	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AVS46_RS00470	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AVS46_RS00500	COG0859	PFAM glycosyl transferase family 9
AVS46_RS00515	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AVS46_RS00525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AVS46_RS00530	COG1127	ABC transporter
AVS46_RS00550	COG1686	Belongs to the peptidase S11 family
AVS46_RS00560	COG2921	Belongs to the UPF0250 family
AVS46_RS00565	COG0321	lipoyl(octanoyl) transferase activity
AVS46_RS00570	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AVS46_RS00605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AVS46_RS00615	COG0018	arginyl-trna synthetase
AVS46_RS00635	COG0395	ABC-type sugar transport system, permease component
AVS46_RS00640	COG1175	transmembrane transport
AVS46_RS00645	COG1653	transport
AVS46_RS00650	COG3842	ATPase activity
AVS46_RS00655	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AVS46_RS00665	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AVS46_RS00685	COG1609	Transcriptional regulator
AVS46_RS00695	COG0154	amidase activity
AVS46_RS00700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVS46_RS00710	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AVS46_RS00720	COG0583	DNA-binding transcription factor activity
AVS46_RS00735	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AVS46_RS00740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AVS46_RS00755	COG1802	Transcriptional regulator
AVS46_RS00770	COG1024	Enoyl-CoA hydratase
AVS46_RS00780	COG3181	Tripartite tricarboxylate transporter family receptor
AVS46_RS00795	COG1984	allophanate hydrolase subunit 2
AVS46_RS00800	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AVS46_RS00810	COG0583	DNA-binding transcription factor activity
AVS46_RS00815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AVS46_RS00825	COG5002	protein histidine kinase activity
AVS46_RS00835	COG5002	protein histidine kinase activity
AVS46_RS00840	COG0745	RESPONSE REGULATOR receiver
AVS46_RS00845	COG2226	methyltransferase
AVS46_RS00860	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AVS46_RS00880	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AVS46_RS00890	COG0513	Belongs to the DEAD box helicase family
AVS46_RS00895	COG1280	lysine exporter protein (LysE YggA)
AVS46_RS00900	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AVS46_RS00935	COG1054	Belongs to the UPF0176 family
AVS46_RS00940	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVS46_RS00940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVS46_RS00950	COG0489	protein tyrosine kinase activity
AVS46_RS00965	COG0717	Belongs to the dCTP deaminase family
AVS46_RS00995	COG2081	HI0933 family
AVS46_RS01005	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AVS46_RS01015	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AVS46_RS01020	COG0509	glycine decarboxylation via glycine cleavage system
AVS46_RS01025	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AVS46_RS01025	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AVS46_RS01065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AVS46_RS01080	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AVS46_RS01090	COG1414	Transcriptional regulator
AVS46_RS01095	COG1028	Short-chain dehydrogenase reductase Sdr
AVS46_RS01100	COG2031	fatty acid transporter
AVS46_RS01105	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVS46_RS01115	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AVS46_RS01120	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AVS46_RS01130	COG4257	antibiotic catabolic process
AVS46_RS01145	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AVS46_RS01150	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AVS46_RS01155	COG1012	belongs to the aldehyde dehydrogenase family
AVS46_RS01190	COG1028	Short-chain dehydrogenase reductase Sdr
AVS46_RS01200	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AVS46_RS01215	COG2188	Transcriptional regulator
AVS46_RS01220	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AVS46_RS01245	COG0617	tRNA 3'-terminal CCA addition
AVS46_RS01260	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AVS46_RS01265	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AVS46_RS01270	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AVS46_RS01275	COG0586	Pfam SNARE associated Golgi protein
AVS46_RS01280	COG0860	N-Acetylmuramoyl-L-alanine amidase
AVS46_RS01285	COG0802	atpase or kinase
AVS46_RS01290	COG0114	fumarate hydratase activity
AVS46_RS01300	COG3181	Tripartite tricarboxylate transporter family receptor
AVS46_RS01310	COG0405	Gamma-glutamyltransferase
AVS46_RS01315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AVS46_RS01325	COG1960	acyl-CoA dehydrogenase activity
AVS46_RS01350	COG1294	oxidase, subunit
AVS46_RS01360	COG4988	ABC transporter
AVS46_RS01365	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AVS46_RS01370	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AVS46_RS01385	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AVS46_RS01415	COG2969	positive regulation of protein catabolic process
AVS46_RS01420	COG0625	glutathione transferase activity
AVS46_RS01425	COG2857	Cytochrome c1
AVS46_RS01430	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AVS46_RS01435	COG0723	plastoquinol--plastocyanin reductase activity
AVS46_RS01440	COG1970	mechanosensitive ion channel activity
AVS46_RS01445	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AVS46_RS01460	COG2808	Putative FMN-binding domain
AVS46_RS01465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AVS46_RS01470	COG0747	negative chemotaxis
AVS46_RS01475	COG0657	acetylesterase activity
AVS46_RS01485	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVS46_RS01490	COG2207	Transcriptional regulator
AVS46_RS01495	COG0129	dihydroxy-acid dehydratase activity
AVS46_RS01500	COG2814	Major facilitator Superfamily
AVS46_RS01505	COG0583	DNA-binding transcription factor activity
AVS46_RS01515	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
AVS46_RS01585	COG1024	Enoyl-CoA hydratase
AVS46_RS01590	COG1960	acyl-CoA dehydrogenase activity
AVS46_RS01615	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AVS46_RS01620	COG0352	thiamine-phosphate diphosphorylase activity
AVS46_RS01635	COG1678	Uncharacterized ACR, COG1678
AVS46_RS01640	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AVS46_RS01645	COG0540	Belongs to the ATCase OTCase family
AVS46_RS01660	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AVS46_RS01670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AVS46_RS01705	COG1234	tRNA 3'-trailer cleavage
AVS46_RS01725	COG3064	Membrane
AVS46_RS01755	COG1683	Conserved Protein
AVS46_RS01760	COG1120	ATPase activity
AVS46_RS01765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AVS46_RS01770	COG4558	Periplasmic binding protein
AVS46_RS01775	COG3720	iron ion transport
AVS46_RS01785	COG3712	iron ion homeostasis
AVS46_RS01790	COG1595	DNA-templated transcription, initiation
AVS46_RS01825	COG1802	Transcriptional regulator
AVS46_RS01835	COG3069	C4-dicarboxylate transmembrane transporter activity
AVS46_RS01845	COG1012	belongs to the aldehyde dehydrogenase family
AVS46_RS01880	COG2860	membrane
AVS46_RS01885	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AVS46_RS01890	COG0708	Exodeoxyribonuclease III
AVS46_RS01895	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AVS46_RS01900	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AVS46_RS01905	COG0154	amidase activity
AVS46_RS01910	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AVS46_RS01915	COG1077	Cell shape determining protein MreB Mrl
AVS46_RS01920	COG1792	Involved in formation and maintenance of cell shape
AVS46_RS01930	COG0768	penicillin binding
AVS46_RS01935	COG0772	Belongs to the SEDS family
AVS46_RS01940	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AVS46_RS01945	COG0471	metal ion transport
AVS46_RS01950	COG1309	transcriptional regulator
AVS46_RS01960	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AVS46_RS01975	COG2823	Periplasmic or secreted lipoprotein
AVS46_RS01980	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AVS46_RS01995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AVS46_RS02015	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AVS46_RS02025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AVS46_RS02045	COG0492	ferredoxin-NADP+ reductase activity
AVS46_RS02055	COG3181	Tripartite tricarboxylate transporter family receptor
AVS46_RS02060	COG1024	Enoyl-CoA hydratase
AVS46_RS02060	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVS46_RS02065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AVS46_RS02070	COG0028	Belongs to the TPP enzyme family
AVS46_RS02095	COG3181	Tripartite tricarboxylate transporter family receptor
AVS46_RS02105	COG0697	spore germination
AVS46_RS02135	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AVS46_RS02140	COG0463	Glycosyl transferase, family 2
AVS46_RS02160	COG0786	glutamate:sodium symporter activity
AVS46_RS02170	COG2031	fatty acid transporter
AVS46_RS02185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AVS46_RS02190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AVS46_RS02215	COG3181	Tripartite tricarboxylate transporter family receptor
AVS46_RS02225	COG0277	FAD linked oxidase domain protein
AVS46_RS02230	COG1960	acyl-CoA dehydrogenase activity
AVS46_RS02235	COG1960	acyl-CoA dehydrogenase activity
AVS46_RS02245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AVS46_RS02260	COG2072	flavoprotein involved in K transport
AVS46_RS02265	COG0604	alcohol dehydrogenase
AVS46_RS02280	COG1024	Enoyl-CoA hydratase
AVS46_RS02300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AVS46_RS02305	COG1522	sequence-specific DNA binding
AVS46_RS02310	COG0183	Belongs to the thiolase family
AVS46_RS02320	COG1960	acyl-CoA dehydrogenase activity
AVS46_RS02365	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AVS46_RS02370	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AVS46_RS02375	COG2890	protein-(glutamine-N5) methyltransferase activity
AVS46_RS02380	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AVS46_RS02390	COG3181	Tripartite tricarboxylate transporter family receptor
AVS46_RS02425	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AVS46_RS02430	COG1660	Displays ATPase and GTPase activities
AVS46_RS02440	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AVS46_RS02440	COG2010	Cytochrome c
AVS46_RS02445	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AVS46_RS02455	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AVS46_RS02460	COG1137	ATPase activity
AVS46_RS02475	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AVS46_RS02485	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AVS46_RS02520	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AVS46_RS02525	COG3568	Endonuclease Exonuclease Phosphatase
AVS46_RS02530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AVS46_RS02560	COG0154	amidase activity
AVS46_RS02570	COG1414	Transcriptional regulator
AVS46_RS02580	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVS46_RS02580	COG1024	Enoyl-CoA hydratase
AVS46_RS02590	COG2132	Multicopper oxidase
AVS46_RS02620	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVS46_RS02645	COG1024	Enoyl-CoA hydratase
AVS46_RS02650	COG1024	Enoyl-CoA hydratase
AVS46_RS02655	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AVS46_RS02675	COG0601	transmembrane transport
AVS46_RS02680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVS46_RS02685	COG4172	Belongs to the ABC transporter superfamily
AVS46_RS02695	COG2195	Cleaves the N-terminal amino acid of tripeptides
AVS46_RS02705	COG0210	DNA helicase
AVS46_RS02710	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AVS46_RS02715	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AVS46_RS02725	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AVS46_RS02730	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AVS46_RS02735	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AVS46_RS02740	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AVS46_RS02745	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AVS46_RS02750	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AVS46_RS02760	COG0356	it plays a direct role in the translocation of protons across the membrane
AVS46_RS02785	COG1024	Enoyl-CoA hydratase
AVS46_RS02790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AVS46_RS02795	COG3634	alkyl hydroperoxide reductase activity
AVS46_RS02805	COG0037	tRNA processing
AVS46_RS02815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AVS46_RS02820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AVS46_RS02825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVS46_RS02830	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AVS46_RS02835	COG2967	ApaG domain
AVS46_RS02840	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AVS46_RS02845	COG0546	phosphoglycolate phosphatase activity
AVS46_RS02855	COG0512	Glutamine amidotransferase of anthranilate synthase
AVS46_RS02860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AVS46_RS02865	COG0134	indole-3-glycerol-phosphate synthase activity
AVS46_RS02885	COG1960	acyl-CoA dehydrogenase activity
AVS46_RS02890	COG0583	DNA-binding transcription factor activity
AVS46_RS02905	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AVS46_RS02910	COG0259	pyridoxamine-phosphate oxidase activity
AVS46_RS02920	COG2814	Major facilitator Superfamily
AVS46_RS02925	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AVS46_RS02930	COG2188	Transcriptional regulator
AVS46_RS02935	COG0318	PFAM AMP-dependent synthetase and ligase
AVS46_RS02955	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AVS46_RS02965	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AVS46_RS02980	COG1215	transferase activity, transferring glycosyl groups
AVS46_RS02990	COG0601	transmembrane transport
AVS46_RS03005	COG0488	(ABC) transporter
AVS46_RS03025	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AVS46_RS03030	COG2894	cell division
AVS46_RS03035	COG0850	regulation of cytokinetic process
AVS46_RS03040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AVS46_RS03045	COG1271	oxidase subunit
AVS46_RS03080	COG2979	Protein of unknown function (DUF533)
AVS46_RS03100	COG1388	LysM domain
AVS46_RS03100	COG0741	lytic transglycosylase activity
AVS46_RS03105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVS46_RS03110	COG2226	methyltransferase
AVS46_RS03115	COG0328	RNA-DNA hybrid ribonuclease activity
AVS46_RS03165	COG2030	dehydratase
AVS46_RS03170	COG0183	Belongs to the thiolase family
AVS46_RS03215	COG1960	acyl-CoA dehydrogenase activity
AVS46_RS03230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AVS46_RS03235	COG1028	Short-chain dehydrogenase reductase Sdr
AVS46_RS03250	COG2718	Belongs to the UPF0229 family
AVS46_RS03255	COG2719	SpoVR family
AVS46_RS03280	COG2188	Transcriptional regulator
AVS46_RS03295	COG0633	Ferredoxin
AVS46_RS03305	COG0829	nickel cation binding
AVS46_RS03310	COG0831	urea catabolic process
AVS46_RS03320	COG0832	Belongs to the urease beta subunit family
AVS46_RS03325	COG0804	urea catabolic process
AVS46_RS03335	COG0830	nickel cation binding
AVS46_RS03340	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AVS46_RS03360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVS46_RS03365	COG0601	transmembrane transport
AVS46_RS03370	COG0747	negative chemotaxis
AVS46_RS03380	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AVS46_RS03385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AVS46_RS03395	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AVS46_RS03405	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AVS46_RS03410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AVS46_RS03415	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AVS46_RS03430	COG0438	transferase activity, transferring glycosyl groups
AVS46_RS03445	COG0438	transferase activity, transferring glycosyl groups
AVS46_RS03450	COG0438	transferase activity, transferring glycosyl groups
AVS46_RS03455	COG0166	Belongs to the GPI family
AVS46_RS03470	COG0277	FAD linked oxidase domain protein
AVS46_RS03475	COG0745	RESPONSE REGULATOR receiver
AVS46_RS03480	COG0642	Histidine kinase
AVS46_RS03485	COG1368	sulfuric ester hydrolase activity
AVS46_RS03495	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AVS46_RS03520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AVS46_RS03530	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AVS46_RS03535	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AVS46_RS03545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AVS46_RS03550	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AVS46_RS03555	COG0193	aminoacyl-tRNA hydrolase activity
AVS46_RS03565	COG0012	GTP binding
AVS46_RS03570	COG0582	viral genome integration into host DNA
AVS46_RS03595	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AVS46_RS03660	COG0745	RESPONSE REGULATOR receiver
AVS46_RS03675	COG1309	transcriptional regulator
AVS46_RS03705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVS46_RS03715	COG0405	Gamma-glutamyltransferase
AVS46_RS03730	COG1280	lysine exporter protein (LysE YggA)
AVS46_RS03790	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AVS46_RS03795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AVS46_RS03805	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AVS46_RS03810	COG0513	Belongs to the DEAD box helicase family
AVS46_RS03820	COG0617	tRNA 3'-terminal CCA addition
AVS46_RS03835	COG0477	Major facilitator Superfamily
AVS46_RS03845	COG0583	DNA-binding transcription factor activity
AVS46_RS03860	COG1950	PFAM Membrane protein of
AVS46_RS03865	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AVS46_RS03880	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AVS46_RS03890	COG1560	Kdo2-lipid A biosynthetic process
AVS46_RS03895	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AVS46_RS03905	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AVS46_RS03915	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
AVS46_RS03925	COG0803	Belongs to the bacterial solute-binding protein 9 family
AVS46_RS03945	COG0735	belongs to the Fur family
AVS46_RS03950	COG0523	cobalamin synthesis protein
AVS46_RS03960	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AVS46_RS03965	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AVS46_RS03975	COG2096	Adenosyltransferase
AVS46_RS03985	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AVS46_RS03990	COG2084	Dehydrogenase
AVS46_RS04040	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AVS46_RS04045	COG0129	dihydroxy-acid dehydratase activity
AVS46_RS04050	COG4654	Cytochrome c, class I
AVS46_RS04055	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AVS46_RS04105	COG1473	amidohydrolase
AVS46_RS04110	COG0418	dihydroorotase activity
AVS46_RS04115	COG0488	(ABC) transporter
AVS46_RS04125	COG2001	Belongs to the MraZ family
AVS46_RS04130	COG0275	rRNA processing
AVS46_RS04135	COG3116	cell division
AVS46_RS04145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AVS46_RS04150	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AVS46_RS04155	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AVS46_RS04165	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AVS46_RS04170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AVS46_RS04175	COG1181	Belongs to the D-alanine--D-alanine ligase family
AVS46_RS04180	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AVS46_RS04190	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AVS46_RS04195	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AVS46_RS04205	COG0739	heme binding
AVS46_RS04210	COG0653	protein targeting
AVS46_RS04230	COG1028	Short-chain dehydrogenase reductase Sdr
AVS46_RS04235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVS46_RS04240	COG1522	sequence-specific DNA binding
AVS46_RS04260	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AVS46_RS04270	COG0557	exoribonuclease II activity
AVS46_RS04275	COG3150	esterase
AVS46_RS04280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AVS46_RS04285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AVS46_RS04290	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AVS46_RS04295	COG0511	ligase activity, forming carbon-carbon bonds
AVS46_RS04300	COG0439	Biotin carboxylase
AVS46_RS04305	COG2264	protein methyltransferase activity
AVS46_RS04315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AVS46_RS04340	COG1696	Membrane protein involved in D-alanine export
AVS46_RS04345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVS46_RS04380	COG1522	sequence-specific DNA binding
AVS46_RS04395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AVS46_RS04400	COG1042	CoA-binding domain protein
AVS46_RS04400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AVS46_RS04400	COG0045	succinate-CoA ligase (ADP-forming) activity
AVS46_RS04415	COG1802	Transcriptional regulator
AVS46_RS04420	COG3069	C4-dicarboxylate transmembrane transporter activity
AVS46_RS04425	COG0513	Belongs to the DEAD box helicase family
AVS46_RS04430	COG0346	lactoylglutathione lyase activity
AVS46_RS04435	COG1335	isochorismatase
AVS46_RS04440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVS46_RS04445	COG1116	anion transmembrane transporter activity
AVS46_RS04460	COG3028	Belongs to the UPF0307 family
AVS46_RS04465	COG0312	modulator of DNA gyrase
AVS46_RS04470	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AVS46_RS04475	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AVS46_RS04480	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AVS46_RS04485	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AVS46_RS04495	COG0316	Belongs to the HesB IscA family
AVS46_RS04500	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AVS46_RS04515	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AVS46_RS04525	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AVS46_RS04530	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AVS46_RS04545	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AVS46_RS04545	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AVS46_RS04575	COG0583	DNA-binding transcription factor activity
AVS46_RS04580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AVS46_RS04615	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AVS46_RS04625	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AVS46_RS04630	COG1845	cytochrome c oxidase, subunit III
AVS46_RS04635	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AVS46_RS04640	COG0640	Transcriptional regulator
AVS46_RS04660	COG3220	belongs to the UPF0276 family
AVS46_RS04705	COG1666	GTP binding
AVS46_RS04740	COG0312	modulator of DNA gyrase
AVS46_RS04745	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AVS46_RS04750	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
AVS46_RS04750	COG3064	Membrane
AVS46_RS04750	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
AVS46_RS04750	COG3210	domain, Protein
AVS46_RS04750	COG3210	domain, Protein
AVS46_RS04750	COG3064	Membrane
AVS46_RS04755	COG0277	FAD linked oxidase domain protein
AVS46_RS04760	COG0277	FAD linked oxidase domain protein
AVS46_RS04765	COG0277	FAD linked oxidase domain protein
AVS46_RS04770	COG0247	lactate metabolic process
AVS46_RS04775	COG2819	hydrolase of the alpha beta superfamily
AVS46_RS04800	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AVS46_RS04820	COG0583	DNA-binding transcription factor activity
AVS46_RS04825	COG0482	sulfurtransferase activity
AVS46_RS04830	COG0730	response to heat
AVS46_RS04835	COG0625	glutathione transferase activity
AVS46_RS04840	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AVS46_RS04845	COG3909	cytochrome
AVS46_RS04885	COG0154	amidase activity
AVS46_RS04890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AVS46_RS04895	COG1024	Enoyl-CoA hydratase
AVS46_RS04910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVS46_RS04925	COG1028	Short-chain dehydrogenase reductase Sdr
AVS46_RS04930	COG1414	Transcriptional regulator
AVS46_RS04940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AVS46_RS04945	COG0251	oxidation-reduction process
AVS46_RS04950	COG0559	Belongs to the binding-protein-dependent transport system permease family
AVS46_RS04970	COG1902	pentaerythritol trinitrate reductase activity
AVS46_RS04985	COG0583	DNA-binding transcription factor activity
AVS46_RS04995	COG0590	tRNA wobble adenosine to inosine editing
AVS46_RS05000	COG2807	transmembrane transport
AVS46_RS05020	COG0154	amidase activity
AVS46_RS05025	COG0307	riboflavin synthase, alpha
AVS46_RS05030	COG3181	Tripartite tricarboxylate transporter family receptor
AVS46_RS05035	COG1522	sequence-specific DNA binding
AVS46_RS05045	COG0318	PFAM AMP-dependent synthetase and ligase
AVS46_RS05055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVS46_RS05075	COG1063	alcohol dehydrogenase
AVS46_RS05100	COG1418	mRNA catabolic process
AVS46_RS05105	COG1448	Aminotransferase
AVS46_RS05110	COG0583	DNA-binding transcription factor activity
AVS46_RS05120	COG0477	Major facilitator Superfamily
AVS46_RS05125	COG1028	Short-chain dehydrogenase reductase Sdr
AVS46_RS05140	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AVS46_RS05145	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AVS46_RS05150	COG0583	DNA-binding transcription factor activity
AVS46_RS05210	COG1028	Short-chain dehydrogenase reductase Sdr
AVS46_RS05215	COG1309	transcriptional regulator
AVS46_RS05225	COG2982	Protein involved in outer membrane biogenesis
AVS46_RS05230	COG2818	Glycosylase
AVS46_RS05250	COG1653	transport
AVS46_RS05260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AVS46_RS05265	COG3842	ATPase activity
AVS46_RS05270	COG0395	ABC-type sugar transport system, permease component
AVS46_RS05275	COG1175	transmembrane transport
AVS46_RS05295	COG3181	Tripartite tricarboxylate transporter family receptor
AVS46_RS05300	COG2186	Transcriptional regulator
AVS46_RS05330	COG1454	alcohol dehydrogenase
AVS46_RS05350	COG2011	ABC-type metal ion transport system permease component
AVS46_RS05355	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AVS46_RS05360	COG1501	Belongs to the glycosyl hydrolase 31 family
AVS46_RS05390	COG0318	PFAM AMP-dependent synthetase and ligase
AVS46_RS05395	COG1473	amidohydrolase
AVS46_RS05405	COG2855	membrane
AVS46_RS05415	COG2239	Acts as a magnesium transporter
AVS46_RS05435	COG3181	Tripartite tricarboxylate transporter family receptor
AVS46_RS05445	COG1722	exodeoxyribonuclease VII activity
AVS46_RS05450	COG0142	geranyltranstransferase activity
AVS46_RS05455	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AVS46_RS05460	COG1469	GTP cyclohydrolase I activity
AVS46_RS05465	COG0360	Binds together with S18 to 16S ribosomal RNA
AVS46_RS05470	COG2965	DNA replication, synthesis of RNA primer
AVS46_RS05475	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AVS46_RS05480	COG0359	binds to the 23S rRNA
AVS46_RS05490	COG0305	Participates in initiation and elongation during chromosome replication
AVS46_RS05500	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AVS46_RS05505	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AVS46_RS05510	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AVS46_RS05515	COG3737	Protein of unknown function (DUF498/DUF598)
AVS46_RS05520	COG0436	Aminotransferase
AVS46_RS05545	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AVS46_RS05575	COG0268	Binds directly to 16S ribosomal RNA
AVS46_RS05585	COG0728	peptidoglycan biosynthetic process
AVS46_RS05595	COG0563	adenylate kinase activity
AVS46_RS05600	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AVS46_RS05605	COG2835	tetraacyldisaccharide 4'-kinase activity
AVS46_RS05610	COG1663	tetraacyldisaccharide 4'-kinase activity
AVS46_RS05615	COG0848	biopolymer transport protein
AVS46_RS05620	COG0811	peptide transport
AVS46_RS05630	COG1570	exodeoxyribonuclease VII activity
AVS46_RS05635	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AVS46_RS05640	COG0038	chloride channel
AVS46_RS05645	COG0183	Belongs to the thiolase family
AVS46_RS05655	COG1278	Cold shock
AVS46_RS05660	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AVS46_RS05670	COG4953	penicillin-binding protein 1C
AVS46_RS05675	COG0542	response to heat
AVS46_RS05680	COG2995	paraquat-inducible protein a
AVS46_RS05685	COG3008	intermembrane lipid transfer
AVS46_RS05685	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AVS46_RS05695	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AVS46_RS05695	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AVS46_RS05695	COG0506	proline dehydrogenase activity
AVS46_RS05730	COG2271	Major facilitator Superfamily
AVS46_RS05735	COG1309	transcriptional regulator
AVS46_RS05745	COG3468	outer membrane autotransporter barrel domain protein
AVS46_RS05775	COG0477	Major facilitator Superfamily
AVS46_RS05785	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AVS46_RS05790	COG1845	cytochrome c oxidase, subunit III
AVS46_RS05795	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AVS46_RS05805	COG1028	Short-chain dehydrogenase reductase Sdr
AVS46_RS05825	COG0789	Transcriptional regulator
AVS46_RS05850	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AVS46_RS05855	COG0697	spore germination
AVS46_RS05865	COG0678	peroxiredoxin activity
AVS46_RS05875	COG0412	Dienelactone hydrolase
AVS46_RS05885	COG0315	cyclic pyranopterin monophosphate synthase activity
AVS46_RS05900	COG0521	Mo-molybdopterin cofactor biosynthetic process
AVS46_RS05905	COG0303	'Molybdopterin
AVS46_RS05910	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AVS46_RS05930	COG0165	Argininosuccinate lyase
AVS46_RS05935	COG0668	transmembrane transport
AVS46_RS05980	COG0747	negative chemotaxis
AVS46_RS05985	COG0601	transmembrane transport
AVS46_RS05990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVS46_RS05995	COG1162	GTPase activity
AVS46_RS06000	COG0501	Belongs to the peptidase M48B family
AVS46_RS06005	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AVS46_RS06015	COG3327	negative regulation of DNA-templated transcription, initiation
AVS46_RS06020	COG3396	Phenylacetate-CoA oxygenase
AVS46_RS06025	COG3460	Phenylacetate-CoA oxygenase
AVS46_RS06030	COG3396	Phenylacetate-CoA oxygenase
AVS46_RS06035	COG2151	metal-sulfur cluster biosynthetic enzyme
AVS46_RS06040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AVS46_RS06050	COG1012	belongs to the aldehyde dehydrogenase family
AVS46_RS06055	COG1024	Enoyl-CoA hydratase
AVS46_RS06060	COG2050	protein possibly involved in aromatic compounds catabolism
AVS46_RS06070	COG3539	Fimbrial protein
AVS46_RS06090	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AVS46_RS06095	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AVS46_RS06095	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AVS46_RS06100	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AVS46_RS06105	COG0047	phosphoribosylformylglycinamidine synthase activity
AVS46_RS06105	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AVS46_RS06110	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
AVS46_RS06110	COG3210	domain, Protein
AVS46_RS06110	COG3064	Membrane
AVS46_RS06135	COG0235	Class ii aldolase
AVS46_RS06140	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AVS46_RS06145	COG0720	synthase
AVS46_RS06150	COG0602	queuosine metabolic process
AVS46_RS06175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AVS46_RS06210	COG3181	Tripartite tricarboxylate transporter family receptor
AVS46_RS06240	COG3842	ATPase activity
AVS46_RS06250	COG0395	ABC-type sugar transport system, permease component
AVS46_RS06280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVS46_RS06285	COG0420	3'-5' exonuclease activity
AVS46_RS06330	COG0519	Catalyzes the synthesis of GMP from XMP
AVS46_RS06330	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AVS46_RS06345	COG3550	peptidyl-serine autophosphorylation
AVS46_RS06355	COG0477	Major facilitator Superfamily
AVS46_RS06370	COG1228	amidohydrolase
AVS46_RS06380	COG1116	anion transmembrane transporter activity
AVS46_RS06385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVS46_RS06425	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AVS46_RS06445	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AVS46_RS06475	COG2814	Major facilitator Superfamily
AVS46_RS06490	COG1280	lysine exporter protein (LysE YggA)
AVS46_RS06505	COG0747	negative chemotaxis
AVS46_RS06510	COG0601	transmembrane transport
AVS46_RS06515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVS46_RS06520	COG4172	Belongs to the ABC transporter superfamily
AVS46_RS06525	COG1609	Transcriptional regulator
AVS46_RS06555	COG0586	Pfam SNARE associated Golgi protein
AVS46_RS06570	COG0500	methyltransferase
AVS46_RS06585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AVS46_RS06595	COG0756	dUTP diphosphatase activity
AVS46_RS06610	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AVS46_RS06615	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AVS46_RS06620	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AVS46_RS06625	COG0072	phenylalanine-tRNA ligase activity
AVS46_RS06625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVS46_RS06630	COG0776	regulation of translation
AVS46_RS06700	COG0540	Belongs to the ATCase OTCase family
AVS46_RS06705	COG2974	May be involved in recombination
AVS46_RS06715	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AVS46_RS06720	COG0583	DNA-binding transcription factor activity
AVS46_RS06740	COG1028	Short-chain dehydrogenase reductase Sdr
AVS46_RS06755	COG3842	ATPase activity
AVS46_RS06760	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVS46_RS06760	COG1024	Enoyl-CoA hydratase
AVS46_RS06780	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AVS46_RS06785	COG2137	regulation of response to DNA damage stimulus
AVS46_RS06795	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AVS46_RS06805	COG0045	succinate-CoA ligase (ADP-forming) activity
AVS46_RS06810	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AVS46_RS06815	COG0861	Integral membrane protein TerC family
AVS46_RS06820	COG0861	Integral membrane protein TerC family
AVS46_RS06825	COG0181	hydroxymethylbilane synthase activity
AVS46_RS06885	COG4964	Belongs to the GSP D family
AVS46_RS06915	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AVS46_RS06925	COG0583	DNA-binding transcription factor activity
AVS46_RS06935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVS46_RS06940	COG4311	Sarcosine oxidase, delta subunit
AVS46_RS06945	COG0446	pyridine nucleotide-disulphide oxidoreductase
AVS46_RS06945	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AVS46_RS06980	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AVS46_RS06985	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AVS46_RS06990	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AVS46_RS06995	COG0735	belongs to the Fur family
AVS46_RS07000	COG0497	DNA recombination
AVS46_RS07005	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AVS46_RS07010	COG1420	regulation of RNA biosynthetic process
AVS46_RS07015	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AVS46_RS07025	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AVS46_RS07035	COG0443	Heat shock 70 kDa protein
AVS46_RS07045	COG0612	Peptidase, M16
AVS46_RS07065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AVS46_RS07110	COG0745	RESPONSE REGULATOR receiver
AVS46_RS07120	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AVS46_RS07125	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AVS46_RS07130	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AVS46_RS07145	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AVS46_RS07165	COG1193	negative regulation of DNA recombination
AVS46_RS07170	COG0492	ferredoxin-NADP+ reductase activity
AVS46_RS07175	COG1674	ftsk spoiiie
AVS46_RS07180	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AVS46_RS07185	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AVS46_RS07190	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AVS46_RS07215	COG3706	GGDEF domain
AVS46_RS07235	COG2814	Major facilitator Superfamily
AVS46_RS07265	COG3486	L-lysine 6-monooxygenase (NADPH) activity
AVS46_RS07280	COG1028	Short-chain dehydrogenase reductase Sdr
AVS46_RS07290	COG3022	response to hydroperoxide
AVS46_RS07300	COG1289	transmembrane transporter activity
AVS46_RS07320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AVS46_RS07330	COG2197	response regulator
AVS46_RS07335	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AVS46_RS07340	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AVS46_RS07345	COG0189	ligase activity
AVS46_RS07355	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AVS46_RS07360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AVS46_RS07370	COG1764	response to oxidative stress
AVS46_RS07375	COG2423	ornithine cyclodeaminase activity
AVS46_RS07385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVS46_RS07390	COG0765	amino acid transport
AVS46_RS07395	COG0765	amino acid transport
AVS46_RS07400	COG1126	abc transporter atp-binding protein
AVS46_RS07455	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AVS46_RS07465	COG2944	sequence-specific DNA binding
AVS46_RS07475	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AVS46_RS07480	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AVS46_RS07485	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AVS46_RS07490	COG0009	L-threonylcarbamoyladenylate synthase
AVS46_RS07495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVS46_RS07500	COG1414	Transcriptional regulator
AVS46_RS07515	COG0765	amino acid transport
AVS46_RS07520	COG1126	abc transporter atp-binding protein
AVS46_RS07525	COG0028	Belongs to the TPP enzyme family
AVS46_RS07540	COG0028	Belongs to the TPP enzyme family
AVS46_RS07545	COG0583	DNA-binding transcription factor activity
AVS46_RS07550	COG4974	Belongs to the 'phage' integrase family
AVS46_RS07555	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AVS46_RS07560	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AVS46_RS07575	COG1686	Belongs to the peptidase S11 family
AVS46_RS07585	COG2814	Major facilitator Superfamily
AVS46_RS07595	COG1074	ATP-dependent DNA helicase activity
AVS46_RS07610	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AVS46_RS07615	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AVS46_RS07620	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AVS46_RS07640	COG2321	neutral zinc metallopeptidase
AVS46_RS07645	COG0009	L-threonylcarbamoyladenylate synthase
AVS46_RS07690	COG3360	Dodecin
AVS46_RS07695	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AVS46_RS07700	COG2850	peptidyl-arginine hydroxylation
AVS46_RS07705	COG3539	Fimbrial protein
AVS46_RS07710	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AVS46_RS07715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AVS46_RS07735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVS46_RS07740	COG0765	amino acid transport
AVS46_RS07745	COG1126	abc transporter atp-binding protein
AVS46_RS07750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AVS46_RS07755	COG1758	RNA polymerase activity
AVS46_RS07760	COG0194	GDP metabolic process
AVS46_RS07765	COG3258	Cytochrome c
AVS46_RS07770	COG2863	cytochrome
AVS46_RS07775	COG1028	Short-chain dehydrogenase reductase Sdr
AVS46_RS07780	COG0791	NLP P60 protein
AVS46_RS07785	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AVS46_RS07805	COG1561	YicC-like family, N-terminal region
AVS46_RS07810	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AVS46_RS07825	COG0840	transmembrane signaling receptor activity
AVS46_RS07830	COG2199	diguanylate cyclase activity
AVS46_RS07830	COG2200	EAL domain
AVS46_RS07835	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AVS46_RS07845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AVS46_RS07850	COG0174	glutamine synthetase
AVS46_RS07860	COG2204	response regulator
AVS46_RS07865	COG0583	DNA-binding transcription factor activity
AVS46_RS07870	COG1741	Belongs to the pirin family
AVS46_RS07875	COG1741	Belongs to the pirin family
AVS46_RS07885	COG3842	ATPase activity
AVS46_RS07890	COG1178	ABC-type Fe3 transport system permease component
AVS46_RS07895	COG1840	ABC-type Fe3 transport system, periplasmic component
AVS46_RS07905	COG0583	DNA-binding transcription factor activity
AVS46_RS07915	COG0656	L-ascorbic acid biosynthetic process
AVS46_RS07930	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AVS46_RS07935	COG0583	DNA-binding transcription factor activity
AVS46_RS07950	COG0783	Belongs to the Dps family
AVS46_RS07970	COG0463	Glycosyl transferase, family 2
AVS46_RS07990	COG0438	transferase activity, transferring glycosyl groups
AVS46_RS08005	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AVS46_RS08030	COG0300	oxidoreductase activity
AVS46_RS08075	COG0861	Integral membrane protein TerC family
AVS46_RS08080	COG1028	Short-chain dehydrogenase reductase Sdr
AVS46_RS08100	COG0714	Associated with various cellular activities
AVS46_RS08135	COG3119	arylsulfatase activity
AVS46_RS08160	COG2197	response regulator
AVS46_RS08170	COG2944	sequence-specific DNA binding
AVS46_RS08175	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
AVS46_RS08180	COG0625	glutathione transferase activity
AVS46_RS08210	COG0179	Fumarylacetoacetate (FAA) hydrolase
AVS46_RS08215	COG1028	Short-chain dehydrogenase reductase Sdr
AVS46_RS08260	COG0431	NADPH-dependent FMN reductase
AVS46_RS08290	COG1028	Short-chain dehydrogenase reductase Sdr
AVS46_RS08295	COG0583	DNA-binding transcription factor activity
AVS46_RS08310	COG3181	Tripartite tricarboxylate transporter family receptor
AVS46_RS08315	COG2111	Na H antiporter
AVS46_RS08315	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AVS46_RS08320	COG1006	Multisubunit Na H antiporter MnhC subunit
AVS46_RS08325	COG0651	ATP synthesis coupled electron transport
AVS46_RS08330	COG1863	multisubunit Na H antiporter MnhE subunit
AVS46_RS08335	COG2212	antiporter activity
AVS46_RS08360	COG0590	tRNA wobble adenosine to inosine editing
AVS46_RS08365	COG1619	proteins homologs of microcin C7 resistance protein MccF
AVS46_RS08370	COG1024	Enoyl-CoA hydratase
AVS46_RS08385	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AVS46_RS08390	COG0488	(ABC) transporter
AVS46_RS08425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AVS46_RS08425	COG1017	nitric oxide dioxygenase activity
AVS46_RS08430	COG1959	2 iron, 2 sulfur cluster binding
AVS46_RS08435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVS46_RS08455	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AVS46_RS08460	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AVS46_RS08465	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AVS46_RS08470	COG0084	hydrolase, TatD family'
AVS46_RS08485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVS46_RS08495	COG1126	abc transporter atp-binding protein
AVS46_RS08500	COG0010	Belongs to the arginase family
AVS46_RS08505	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AVS46_RS08510	COG1012	belongs to the aldehyde dehydrogenase family
AVS46_RS08520	COG0028	Belongs to the TPP enzyme family
AVS46_RS08530	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AVS46_RS08530	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AVS46_RS08540	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AVS46_RS08555	COG3189	MarR family transcriptional regulator
AVS46_RS08560	COG2010	Cytochrome c
AVS46_RS08585	COG4336	lyase activity
AVS46_RS08595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVS46_RS08595	COG2205	protein histidine kinase activity
AVS46_RS08600	COG2197	response regulator
AVS46_RS08605	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
AVS46_RS08605	COG3064	Membrane
AVS46_RS08605	COG3210	domain, Protein
AVS46_RS08615	COG3121	Chaperone
AVS46_RS08620	COG3188	usher protein
AVS46_RS08625	COG3539	Fimbrial protein
AVS46_RS08630	COG2831	hemolysin activation secretion protein
AVS46_RS08645	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AVS46_RS08670	COG0583	DNA-binding transcription factor activity
AVS46_RS08695	COG0668	transmembrane transport
AVS46_RS08715	COG0483	inositol monophosphate 1-phosphatase activity
AVS46_RS08720	COG1253	flavin adenine dinucleotide binding
AVS46_RS08725	COG1968	undecaprenyl-diphosphatase activity
AVS46_RS08730	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AVS46_RS08745	COG0215	cysteine-tRNA ligase activity
AVS46_RS08755	COG0825	malonyl-CoA metabolic process
AVS46_RS08765	COG0037	tRNA processing
AVS46_RS08770	COG0527	aspartate kinase activity
AVS46_RS08795	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVS46_RS08800	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AVS46_RS08800	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AVS46_RS08815	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AVS46_RS08820	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
AVS46_RS08825	COG1028	Short-chain dehydrogenase reductase Sdr
AVS46_RS08835	COG0583	DNA-binding transcription factor activity
AVS46_RS08865	COG3842	ATPase activity
AVS46_RS08875	COG0446	pyridine nucleotide-disulphide oxidoreductase
AVS46_RS08875	COG1902	pentaerythritol trinitrate reductase activity
AVS46_RS08880	COG1414	Transcriptional regulator
AVS46_RS08885	COG1832	CoA-binding protein
AVS46_RS08895	COG0251	oxidation-reduction process
AVS46_RS08920	COG1902	pentaerythritol trinitrate reductase activity
AVS46_RS08930	COG1215	transferase activity, transferring glycosyl groups
AVS46_RS08935	COG1649	PFAM Uncharacterised BCR, COG1649
AVS46_RS08935	COG0726	polysaccharide deacetylase
AVS46_RS08955	COG1846	Transcriptional regulator
AVS46_RS08960	COG2197	response regulator
AVS46_RS08975	COG0166	Belongs to the GPI family
AVS46_RS08980	COG1045	serine acetyltransferase
AVS46_RS08990	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AVS46_RS08995	COG0483	inositol monophosphate 1-phosphatase activity
AVS46_RS09000	COG1012	belongs to the aldehyde dehydrogenase family
AVS46_RS09005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AVS46_RS09020	COG0210	DNA helicase
AVS46_RS09025	COG0598	Magnesium transport protein CorA
AVS46_RS09035	COG0747	negative chemotaxis
AVS46_RS09040	COG0601	transmembrane transport
AVS46_RS09045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVS46_RS09050	COG4172	Belongs to the ABC transporter superfamily
AVS46_RS09055	COG1846	Transcriptional regulator
AVS46_RS09105	COG4964	Belongs to the GSP D family
AVS46_RS09145	COG2204	response regulator
AVS46_RS09160	COG1595	DNA-templated transcription, initiation
AVS46_RS09170	COG3474	cytochrome
AVS46_RS09175	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AVS46_RS09190	COG3384	dioxygenase
AVS46_RS09195	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AVS46_RS09220	COG2885	chlorophyll binding
AVS46_RS09255	COG0697	spore germination
AVS46_RS09260	COG0730	response to heat
AVS46_RS09280	COG0583	DNA-binding transcription factor activity
AVS46_RS09285	COG0427	acetyl-CoA hydrolase
AVS46_RS09340	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVS46_RS09345	COG0154	amidase activity
AVS46_RS09355	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AVS46_RS09370	COG0495	leucyl-tRNA aminoacylation
AVS46_RS09375	COG2814	Major facilitator Superfamily
AVS46_RS09405	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AVS46_RS09410	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AVS46_RS09415	COG2814	Major facilitator Superfamily
AVS46_RS09420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AVS46_RS09435	COG4176	ABC-type proline glycine betaine transport system permease component
AVS46_RS09445	COG1942	4-Oxalocrotonate Tautomerase
AVS46_RS09450	COG0183	Belongs to the thiolase family
AVS46_RS09460	COG1802	Transcriptional regulator
AVS46_RS09470	COG1024	Enoyl-CoA hydratase
AVS46_RS09475	COG0318	PFAM AMP-dependent synthetase and ligase
AVS46_RS09480	COG0318	PFAM AMP-dependent synthetase and ligase
AVS46_RS09490	COG2032	superoxide dismutase activity
AVS46_RS09505	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AVS46_RS09530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVS46_RS09535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AVS46_RS09545	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AVS46_RS09550	COG0736	holo-[acyl-carrier-protein] synthase activity
AVS46_RS09555	COG1472	Belongs to the glycosyl hydrolase 3 family
AVS46_RS09560	COG0322	excinuclease ABC activity
AVS46_RS09565	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AVS46_RS09580	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AVS46_RS09580	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AVS46_RS09585	COG2224	Isocitrate lyase
AVS46_RS09605	COG0559	Belongs to the binding-protein-dependent transport system permease family
AVS46_RS09615	COG4638	Rieske (2fe-2S)
AVS46_RS09625	COG1024	Enoyl-CoA hydratase
AVS46_RS09635	COG0633	Ferredoxin
AVS46_RS09640	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AVS46_RS09655	COG0183	Belongs to the thiolase family
AVS46_RS09750	COG2346	COG2346, Truncated hemoglobins
AVS46_RS09830	COG2207	Transcriptional regulator
AVS46_RS09875	COG1132	(ABC) transporter
AVS46_RS09900	COG0659	secondary active sulfate transmembrane transporter activity
AVS46_RS09930	COG2169	Transcriptional regulator
AVS46_RS09935	COG5507	3-demethylubiquinone-9 3-methyltransferase
AVS46_RS09940	COG0384	phenazine biosynthesis protein PhzF
AVS46_RS09945	COG0583	DNA-binding transcription factor activity
AVS46_RS09950	COG2733	membrane
AVS46_RS09965	COG1012	belongs to the aldehyde dehydrogenase family
AVS46_RS09970	COG3284	Transcriptional regulator
AVS46_RS09990	COG1380	Effector of murein hydrolase LrgA
AVS46_RS09995	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AVS46_RS09995	COG4106	trans-aconitate 2-methyltransferase activity
AVS46_RS10005	COG0156	8-amino-7-oxononanoate synthase activity
AVS46_RS10075	COG1131	(ABC) transporter
AVS46_RS10080	COG0842	Transport permease protein
AVS46_RS10085	COG0628	permease
AVS46_RS10120	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AVS46_RS10130	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AVS46_RS10135	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AVS46_RS10140	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AVS46_RS10145	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AVS46_RS10150	COG0330	HflC and HflK could
AVS46_RS10155	COG0330	HflC and HflK could
AVS46_RS10160	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AVS46_RS10165	COG1923	regulation of RNA biosynthetic process
AVS46_RS10170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AVS46_RS10175	COG1160	GTP binding
AVS46_RS10180	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AVS46_RS10185	COG2976	Protein conserved in bacteria
AVS46_RS10190	COG0124	histidyl-tRNA synthetase
AVS46_RS10195	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AVS46_RS10205	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AVS46_RS10210	COG0105	UTP biosynthetic process
AVS46_RS10215	COG0525	valine-tRNA ligase activity
AVS46_RS10230	COG0642	Histidine kinase
AVS46_RS10250	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AVS46_RS10255	COG0336	Belongs to the RNA methyltransferase TrmD family
AVS46_RS10260	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AVS46_RS10265	COG0228	four-way junction DNA binding
AVS46_RS10275	COG0425	Belongs to the sulfur carrier protein TusA family
AVS46_RS10280	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AVS46_RS10325	COG0154	amidase activity
AVS46_RS10330	COG4172	Belongs to the ABC transporter superfamily
AVS46_RS10335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVS46_RS10340	COG0601	transmembrane transport
AVS46_RS10345	COG0747	negative chemotaxis
AVS46_RS10375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVS46_RS10385	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AVS46_RS10400	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AVS46_RS10405	COG3395	kinase activity
AVS46_RS10420	COG1024	Enoyl-CoA hydratase
AVS46_RS10440	COG0633	Ferredoxin
AVS46_RS10445	COG0443	Heat shock 70 kDa protein
AVS46_RS10450	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AVS46_RS10455	COG0316	Belongs to the HesB IscA family
AVS46_RS10460	COG0822	iron-sulfur transferase activity
AVS46_RS10465	COG1104	cysteine desulfurase activity
AVS46_RS10475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AVS46_RS10480	COG0556	nucleotide-excision repair
AVS46_RS10490	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AVS46_RS10495	COG3468	outer membrane autotransporter barrel domain protein
AVS46_RS10525	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AVS46_RS10540	COG1960	acyl-CoA dehydrogenase activity
AVS46_RS10545	COG1028	Short-chain dehydrogenase reductase Sdr
AVS46_RS10550	COG0183	Belongs to the thiolase family
AVS46_RS10560	COG1024	Enoyl-CoA hydratase
AVS46_RS10575	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AVS46_RS10580	COG0583	DNA-binding transcription factor activity
AVS46_RS10585	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AVS46_RS10590	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AVS46_RS10595	COG0740	serine-type endopeptidase activity
AVS46_RS10600	COG0544	peptidyl-prolyl cis-trans isomerase activity
AVS46_RS10620	COG1278	Cold shock
AVS46_RS10655	COG2171	N-acyltransferase activity
AVS46_RS10660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AVS46_RS10665	COG2890	protein-(glutamine-N5) methyltransferase activity
AVS46_RS10670	COG0488	(ABC) transporter
AVS46_RS10675	COG4771	TonB-dependent receptor
AVS46_RS10680	COG0210	DNA helicase
AVS46_RS10700	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AVS46_RS10705	COG0196	riboflavin kinase activity
AVS46_RS10710	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AVS46_RS10715	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AVS46_RS10720	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AVS46_RS10730	COG1522	sequence-specific DNA binding
AVS46_RS10750	COG2951	lytic endotransglycosylase activity
AVS46_RS10755	COG2833	Protein of unknown function (DUF455)
AVS46_RS10775	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AVS46_RS10775	COG0189	ligase activity
AVS46_RS10780	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AVS46_RS10780	COG1181	Belongs to the D-alanine--D-alanine ligase family
AVS46_RS10785	COG3237	CsbD-like
AVS46_RS10795	COG2823	Periplasmic or secreted lipoprotein
AVS46_RS10810	COG4181	ATPase activity
AVS46_RS10820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AVS46_RS10825	COG0584	glycerophosphoryl diester phosphodiesterase
AVS46_RS10830	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AVS46_RS10840	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AVS46_RS10840	COG0678	peroxiredoxin activity
AVS46_RS10850	COG0789	Transcriptional regulator
AVS46_RS10855	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AVS46_RS10885	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AVS46_RS10890	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AVS46_RS10900	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AVS46_RS10905	COG2252	PERMEase
AVS46_RS10915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AVS46_RS10945	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AVS46_RS10950	COG2358	TRAP transporter, solute receptor (TAXI family
AVS46_RS10980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AVS46_RS10985	COG1366	Belongs to the anti-sigma-factor antagonist family
AVS46_RS10990	COG2172	sigma factor antagonist activity
AVS46_RS10995	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AVS46_RS11005	COG2770	Histidine kinase
AVS46_RS11005	COG2208	phosphoserine phosphatase activity
AVS46_RS11030	COG1595	DNA-templated transcription, initiation
AVS46_RS11045	COG4792	protein secretion
AVS46_RS11050	COG4791	protein targeting
AVS46_RS11055	COG4794	Type iii secretion
AVS46_RS11060	COG4790	Type iii secretion
AVS46_RS11095	COG4669	(LipO)protein
AVS46_RS11160	COG4789	Type iii secretion
AVS46_RS11190	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AVS46_RS11195	COG0840	transmembrane signaling receptor activity
AVS46_RS11200	COG2233	PERMEase
AVS46_RS11220	COG0492	ferredoxin-NADP+ reductase activity
AVS46_RS11225	COG1840	ABC-type Fe3 transport system, periplasmic component
AVS46_RS11230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AVS46_RS11235	COG1178	ABC-type Fe3 transport system permease component
AVS46_RS11240	COG3842	ATPase activity
AVS46_RS11245	COG0583	DNA-binding transcription factor activity
AVS46_RS11265	COG0501	Belongs to the peptidase M48B family
AVS46_RS11275	COG0697	spore germination
AVS46_RS11285	COG1846	Transcriptional regulator
AVS46_RS11295	COG1566	PFAM secretion protein HlyD family protein
AVS46_RS11300	COG2814	Major facilitator Superfamily
AVS46_RS11305	COG0473	3-isopropylmalate dehydrogenase activity
AVS46_RS11315	COG0747	negative chemotaxis
AVS46_RS11325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVS46_RS11340	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AVS46_RS11365	COG1012	belongs to the aldehyde dehydrogenase family
AVS46_RS11375	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AVS46_RS11380	COG1115	amino acid carrier protein
AVS46_RS11385	COG0433	COG0433 Predicted ATPase
AVS46_RS11390	COG0217	transcriptional regulatory protein
AVS46_RS11395	COG0151	Belongs to the GarS family
AVS46_RS11400	COG0408	coproporphyrinogen oxidase activity
AVS46_RS11405	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AVS46_RS11410	COG0799	negative regulation of ribosome biogenesis
AVS46_RS11415	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AVS46_RS11420	COG0424	maF-like protein
AVS46_RS11425	COG3468	outer membrane autotransporter barrel domain protein
AVS46_RS11465	COG1530	ribonuclease E activity
AVS46_RS11470	COG0077	Prephenate dehydratase
AVS46_RS11485	COG1132	(ABC) transporter
AVS46_RS11490	COG0859	PFAM glycosyl transferase family 9
AVS46_RS11515	COG2194	sulfuric ester hydrolase activity
AVS46_RS11520	COG0438	transferase activity, transferring glycosyl groups
AVS46_RS11525	COG0463	Glycosyl transferase, family 2
AVS46_RS11530	COG0726	polysaccharide deacetylase
AVS46_RS11535	COG0438	transferase activity, transferring glycosyl groups
AVS46_RS11550	COG1643	Atp-dependent helicase
AVS46_RS11555	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AVS46_RS11555	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AVS46_RS11560	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AVS46_RS11570	COG0704	Plays a role in the regulation of phosphate uptake
AVS46_RS11575	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AVS46_RS11580	COG1960	acyl-CoA dehydrogenase activity
AVS46_RS11605	COG1177	transmembrane transport
AVS46_RS11610	COG1176	ABC-type spermidine putrescine transport system, permease component I
AVS46_RS11615	COG3842	ATPase activity
AVS46_RS11620	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AVS46_RS11635	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AVS46_RS11640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AVS46_RS11650	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AVS46_RS11650	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AVS46_RS11670	COG0372	Belongs to the citrate synthase family
AVS46_RS11675	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AVS46_RS11680	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AVS46_RS11685	COG1053	succinate dehydrogenase
AVS46_RS11690	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AVS46_RS11695	COG2009	succinate dehydrogenase
AVS46_RS11700	COG2188	Transcriptional regulator
AVS46_RS11705	COG0039	L-malate dehydrogenase activity
AVS46_RS11735	COG1981	membrane
AVS46_RS11760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AVS46_RS11770	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AVS46_RS11800	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AVS46_RS11805	COG0148	phosphopyruvate hydratase activity
AVS46_RS11815	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AVS46_RS11820	COG0504	CTP synthase activity
AVS46_RS11845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVS46_RS11855	COG0747	negative chemotaxis
AVS46_RS11860	COG4172	Belongs to the ABC transporter superfamily
AVS46_RS11865	COG1446	asparaginase
AVS46_RS11895	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AVS46_RS11910	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AVS46_RS11915	COG0697	spore germination
AVS46_RS11920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AVS46_RS11930	COG3193	protein, possibly involved in utilization of glycolate and propanediol
AVS46_RS11935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AVS46_RS11940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AVS46_RS11945	COG0791	NLP P60 protein
AVS46_RS11960	COG0583	DNA-binding transcription factor activity
AVS46_RS11975	COG0583	DNA-binding transcription factor activity
AVS46_RS11985	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AVS46_RS12000	COG0670	Belongs to the BI1 family
AVS46_RS12005	COG3181	Tripartite tricarboxylate transporter family receptor
AVS46_RS12015	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AVS46_RS12025	COG1381	Involved in DNA repair and RecF pathway recombination
AVS46_RS12030	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AVS46_RS12035	COG0571	ribonuclease III activity
AVS46_RS12040	COG0681	Belongs to the peptidase S26 family
AVS46_RS12045	COG0481	GTPase activity
AVS46_RS12050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AVS46_RS12075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AVS46_RS12080	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVS46_RS12095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AVS46_RS12100	COG0416	fatty acid biosynthetic process
AVS46_RS12105	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AVS46_RS12110	COG1399	metal-binding, possibly nucleic acid-binding protein
AVS46_RS12115	COG0424	maF-like protein
AVS46_RS12125	COG3023	N-Acetylmuramoyl-L-alanine amidase
AVS46_RS12130	COG1289	transmembrane transporter activity
AVS46_RS12140	COG3022	response to hydroperoxide
AVS46_RS12155	COG0135	phosphoribosylanthranilate isomerase activity
AVS46_RS12170	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AVS46_RS12175	COG0101	tRNA pseudouridine synthase activity
AVS46_RS12185	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AVS46_RS12190	COG0473	3-isopropylmalate dehydrogenase activity
AVS46_RS12195	COG0066	3-isopropylmalate dehydratase activity
AVS46_RS12200	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AVS46_RS12210	COG1122	ATPase activity
AVS46_RS12240	COG0437	4 iron, 4 sulfur cluster binding
AVS46_RS12245	COG0243	molybdopterin cofactor binding
AVS46_RS12245	COG3383	formate dehydrogenase (NAD+) activity
AVS46_RS12275	COG0489	protein tyrosine kinase activity
AVS46_RS12280	COG0746	molybdenum cofactor guanylyltransferase activity
AVS46_RS12285	COG0303	'Molybdopterin
AVS46_RS12290	COG1763	Mo-molybdopterin cofactor biosynthetic process
AVS46_RS12300	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AVS46_RS12305	COG5001	Diguanylate cyclase
AVS46_RS12325	COG3842	ATPase activity
AVS46_RS12335	COG0406	alpha-ribazole phosphatase activity
AVS46_RS12345	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AVS46_RS12350	COG0505	Belongs to the CarA family
AVS46_RS12355	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AVS46_RS12385	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AVS46_RS12390	COG1960	acyl-CoA dehydrogenase activity
AVS46_RS12400	COG2867	negative regulation of translational initiation
AVS46_RS12410	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AVS46_RS12415	COG3706	GGDEF domain
AVS46_RS12420	COG0330	HflC and HflK could
AVS46_RS12435	COG0519	Catalyzes the synthesis of GMP from XMP
AVS46_RS12435	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AVS46_RS12445	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AVS46_RS12450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AVS46_RS12455	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AVS46_RS12460	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AVS46_RS12470	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AVS46_RS12475	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AVS46_RS12480	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AVS46_RS12485	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AVS46_RS12490	COG0750	zinc metalloprotease
AVS46_RS12495	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AVS46_RS12505	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AVS46_RS12510	COG0233	cytoplasmic translational termination
AVS46_RS12515	COG0528	UMP kinase activity
AVS46_RS12520	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AVS46_RS12525	COG0052	Belongs to the universal ribosomal protein uS2 family
AVS46_RS12530	COG0024	Methionine aminopeptidase
AVS46_RS12535	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AVS46_RS12565	COG0285	dihydrofolate synthase activity
AVS46_RS12600	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AVS46_RS12610	COG1677	Flagellar hook-basal body complex protein FliE
AVS46_RS12620	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AVS46_RS12630	COG1157	protein secretion by the type III secretion system
AVS46_RS12655	COG1580	Controls the rotational direction of flagella during chemotaxis
AVS46_RS12675	COG1338	Plays a role in the flagellum-specific transport system
AVS46_RS12695	COG0840	transmembrane signaling receptor activity
AVS46_RS12700	COG0840	transmembrane signaling receptor activity
AVS46_RS12705	COG0840	transmembrane signaling receptor activity
AVS46_RS12715	COG1256	bacterial-type flagellum assembly
AVS46_RS12725	COG1706	bacterial-type flagellum-dependent cell motility
AVS46_RS12730	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AVS46_RS12745	COG1749	Flagellar hook protein flgE
AVS46_RS12755	COG1558	bacterial-type flagellum-dependent cell motility
AVS46_RS12760	COG1815	bacterial-type flagellum-dependent cell motility
AVS46_RS12800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVS46_RS12805	COG0765	amino acid transport
AVS46_RS12810	COG1126	abc transporter atp-binding protein
AVS46_RS12825	COG4948	Mandelate Racemase Muconate Lactonizing
AVS46_RS12830	COG3181	Tripartite tricarboxylate transporter family receptor
AVS46_RS12840	COG0066	3-isopropylmalate dehydratase activity
AVS46_RS12855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AVS46_RS12865	COG3181	Tripartite tricarboxylate transporter family receptor
AVS46_RS12875	COG1802	Transcriptional regulator
AVS46_RS12890	COG0583	DNA-binding transcription factor activity
AVS46_RS12910	COG1695	Transcriptional regulator
AVS46_RS12920	COG3568	Endonuclease Exonuclease Phosphatase
AVS46_RS12925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AVS46_RS12940	COG0392	lysyltransferase activity
AVS46_RS12980	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AVS46_RS12990	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AVS46_RS13010	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AVS46_RS13040	COG0667	Aldo Keto reductase
AVS46_RS13055	COG2259	Doxx family
AVS46_RS13085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AVS46_RS13105	COG0386	Belongs to the glutathione peroxidase family
AVS46_RS13110	COG0625	glutathione transferase activity
AVS46_RS13135	COG0688	phosphatidylethanolamine metabolic process
AVS46_RS13145	COG1464	Belongs to the NlpA lipoprotein family
AVS46_RS13160	COG2363	Small membrane protein
AVS46_RS13185	COG3842	ATPase activity
AVS46_RS13190	COG0395	ABC-type sugar transport system, permease component
AVS46_RS13195	COG1175	transmembrane transport
AVS46_RS13200	COG1653	transport
AVS46_RS13210	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AVS46_RS13225	COG0559	Belongs to the binding-protein-dependent transport system permease family
AVS46_RS13245	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AVS46_RS13260	COG0697	spore germination
AVS46_RS13270	COG2311	Membrane
AVS46_RS13295	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AVS46_RS13305	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AVS46_RS13310	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AVS46_RS13315	COG1760	l-serine dehydratase
AVS46_RS13320	COG1283	sodium-dependent phosphate transmembrane transporter activity
AVS46_RS13325	COG0412	Dienelactone hydrolase
AVS46_RS13340	COG1611	Belongs to the LOG family
AVS46_RS13360	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AVS46_RS13365	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AVS46_RS13370	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AVS46_RS13375	COG2251	uridine kinase activity
AVS46_RS13375	COG0195	Participates in both transcription termination and antitermination
AVS46_RS13380	COG0779	Required for maturation of 30S ribosomal subunits
AVS46_RS13385	COG1187	pseudouridine synthase activity
AVS46_RS13390	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AVS46_RS13400	COG0583	DNA-binding transcription factor activity
AVS46_RS13410	COG0523	cobalamin synthesis protein
AVS46_RS13430	COG0625	glutathione transferase activity
AVS46_RS13435	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AVS46_RS13440	COG1047	Peptidyl-prolyl cis-trans
AVS46_RS13445	COG2003	Belongs to the UPF0758 family
AVS46_RS13450	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AVS46_RS13455	COG3483	tryptophan 2,3-dioxygenase activity
AVS46_RS13460	COG0254	rRNA binding
AVS46_RS13470	COG0534	Mate efflux family protein
AVS46_RS13490	COG2304	oxidoreductase activity
AVS46_RS13510	COG1028	Short-chain dehydrogenase reductase Sdr
AVS46_RS13515	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AVS46_RS13520	COG1562	ergosterol biosynthetic process
AVS46_RS13525	COG1562	ergosterol biosynthetic process
AVS46_RS13530	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AVS46_RS13530	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AVS46_RS13535	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AVS46_RS13545	COG0842	Transport permease protein
AVS46_RS13550	COG1131	(ABC) transporter
AVS46_RS13570	COG1477	protein flavinylation
AVS46_RS13585	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AVS46_RS13600	COG5564	TIM-barrel signal transduction protein
AVS46_RS13605	COG5441	Belongs to the UPF0261 family
AVS46_RS13615	COG3468	outer membrane autotransporter barrel domain protein
AVS46_RS13620	COG3468	outer membrane autotransporter barrel domain protein
AVS46_RS13635	COG0542	response to heat
AVS46_RS13640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVS46_RS13655	COG0494	nUDIX hydrolase
AVS46_RS13660	COG3530	Putative quorum-sensing-regulated virulence factor
AVS46_RS13670	COG1595	DNA-templated transcription, initiation
AVS46_RS13675	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AVS46_RS13710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVS46_RS13715	COG0765	amino acid transport
AVS46_RS13720	COG0765	amino acid transport
AVS46_RS13750	COG2988	succinylglutamate desuccinylase activity
AVS46_RS13775	COG3181	Tripartite tricarboxylate transporter family receptor
AVS46_RS13780	COG2084	Dehydrogenase
AVS46_RS13795	COG1619	proteins homologs of microcin C7 resistance protein MccF
AVS46_RS13810	COG2814	Major facilitator Superfamily
AVS46_RS13820	COG0583	DNA-binding transcription factor activity
AVS46_RS13860	COG0672	)-iron permease
AVS46_RS13875	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
AVS46_RS13880	COG1028	Short-chain dehydrogenase reductase Sdr
AVS46_RS13885	COG3243	poly(R)-hydroxyalkanoic acid synthase
AVS46_RS13895	COG0564	pseudouridine synthase activity
AVS46_RS13905	COG1199	ATP-dependent helicase activity
AVS46_RS13910	COG2183	response to ionizing radiation
AVS46_RS13915	COG0180	Tryptophanyl-tRNA synthetase
AVS46_RS13940	COG3181	Tripartite tricarboxylate transporter family receptor
AVS46_RS13950	COG0583	DNA-binding transcription factor activity
AVS46_RS13955	COG1028	Short-chain dehydrogenase reductase Sdr
AVS46_RS13960	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AVS46_RS13965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AVS46_RS13970	COG0508	dehydrogenase complex catalyzes the overall conversion of
AVS46_RS13975	COG0567	Dehydrogenase, E1 component
AVS46_RS13985	COG1522	sequence-specific DNA binding
AVS46_RS13995	COG0281	malic enzyme
AVS46_RS13995	COG0280	phosphate acetyltransferase
AVS46_RS14000	COG3539	Fimbrial protein
AVS46_RS14015	COG0613	PHP domain protein
AVS46_RS14025	COG0658	competence protein
AVS46_RS14025	COG2333	competence protein COMEC
AVS46_RS14055	COG0084	hydrolase, TatD family'
AVS46_RS14060	COG1136	(ABC) transporter
AVS46_RS14075	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AVS46_RS14085	COG1028	Short-chain dehydrogenase reductase Sdr
AVS46_RS14090	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AVS46_RS14105	COG1022	Amp-dependent synthetase and ligase
AVS46_RS14140	COG2205	protein histidine kinase activity
AVS46_RS14145	COG0745	RESPONSE REGULATOR receiver
AVS46_RS14150	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AVS46_RS14160	COG1295	ribonuclease BN
AVS46_RS14175	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AVS46_RS14205	COG1534	Rna-binding protein
AVS46_RS14210	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AVS46_RS14215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AVS46_RS14225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AVS46_RS14235	COG0248	Ppx GppA phosphatase
AVS46_RS14260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AVS46_RS14275	COG2732	(Barnase) inhibitor
AVS46_RS14285	COG0280	phosphate acetyltransferase
AVS46_RS14285	COG0281	malic enzyme
AVS46_RS14295	COG0436	Aminotransferase
AVS46_RS14300	COG0741	lytic transglycosylase activity
AVS46_RS14305	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AVS46_RS14330	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AVS46_RS14330	COG1648	precorrin-2 dehydrogenase activity
AVS46_RS14335	COG3468	outer membrane autotransporter barrel domain protein
AVS46_RS14345	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AVS46_RS14350	COG2027	D-alanyl-D-alanine carboxypeptidase
AVS46_RS14355	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AVS46_RS14360	COG0343	queuine tRNA-ribosyltransferase activity
AVS46_RS14365	COG1862	Preprotein translocase
AVS46_RS14370	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AVS46_RS14375	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AVS46_RS14390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AVS46_RS14395	COG1702	phosphate starvation-inducible protein PhoH
AVS46_RS14400	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AVS46_RS14405	COG4535	Mg2 and Co2 transporter CorC
AVS46_RS14415	COG0667	Aldo Keto reductase
AVS46_RS14440	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AVS46_RS14445	COG0745	RESPONSE REGULATOR receiver
AVS46_RS14450	COG2201	protein-glutamate methylesterase activity
AVS46_RS14460	COG0840	transmembrane signaling receptor activity
AVS46_RS14475	COG0745	RESPONSE REGULATOR receiver
AVS46_RS14510	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AVS46_RS14520	COG0739	heme binding
AVS46_RS14530	COG0521	Mo-molybdopterin cofactor biosynthetic process
AVS46_RS14540	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AVS46_RS14575	COG0625	glutathione transferase activity
AVS46_RS14590	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AVS46_RS14595	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AVS46_RS14600	COG0126	phosphoglycerate kinase activity
AVS46_RS14605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AVS46_RS14610	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AVS46_RS14615	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AVS46_RS14625	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AVS46_RS14630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AVS46_RS14635	COG0508	dehydrogenase complex catalyzes the overall conversion of
AVS46_RS14640	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AVS46_RS14650	COG4566	intracellular signal transduction
AVS46_RS14655	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AVS46_RS14660	COG0339	signal peptide processing
AVS46_RS14665	COG1999	signal sequence binding
AVS46_RS14685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVS46_RS14695	COG1187	pseudouridine synthase activity
AVS46_RS14700	COG3161	chorismate lyase activity
AVS46_RS14705	COG2814	Major facilitator Superfamily
AVS46_RS14715	COG0667	Aldo Keto reductase
AVS46_RS14730	COG0335	large ribosomal subunit rRNA binding
AVS46_RS14760	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AVS46_RS14765	COG4208	sulfate ABC transporter
AVS46_RS14770	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AVS46_RS14785	COG0450	alkyl hydroperoxide reductase
AVS46_RS14790	COG1960	acyl-CoA dehydrogenase activity
AVS46_RS14805	COG0123	including yeast histone deacetylase and acetoin utilization protein
AVS46_RS14810	COG2951	lytic endotransglycosylase activity
AVS46_RS14825	COG1596	polysaccharide export
AVS46_RS14825	COG1555	photosystem II stabilization
AVS46_RS14830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AVS46_RS14835	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AVS46_RS14840	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AVS46_RS14860	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AVS46_RS14865	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AVS46_RS14870	COG0287	Prephenate dehydrogenase
AVS46_RS14880	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AVS46_RS14895	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AVS46_RS14905	COG2814	Major facilitator Superfamily
AVS46_RS14930	COG0583	DNA-binding transcription factor activity
AVS46_RS14970	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AVS46_RS14985	COG0667	Aldo Keto reductase
AVS46_RS14995	COG5265	(ABC) transporter
AVS46_RS15040	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AVS46_RS15045	COG0439	Biotin carboxylase
AVS46_RS15050	COG2188	Transcriptional regulator
AVS46_RS15075	COG0511	ligase activity, forming carbon-carbon bonds
AVS46_RS15085	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AVS46_RS15105	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
AVS46_RS15125	COG0500	methyltransferase
AVS46_RS15130	COG5265	(ABC) transporter
AVS46_RS15145	COG0028	Belongs to the TPP enzyme family
AVS46_RS15150	COG0440	acetolactate synthase activity
AVS46_RS15155	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AVS46_RS15160	COG1183	phosphatidylcholine synthase activity
AVS46_RS15175	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AVS46_RS15180	COG1185	polyribonucleotide nucleotidyltransferase activity
AVS46_RS15195	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AVS46_RS15215	COG0149	triose-phosphate isomerase activity
AVS46_RS15220	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AVS46_RS15230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AVS46_RS15240	COG3799	methylaspartate ammonia-lyase activity
AVS46_RS15275	COG0583	DNA-binding transcription factor activity
AVS46_RS15280	COG0626	cystathionine gamma-synthase activity
AVS46_RS15285	COG3608	succinylglutamate desuccinylase aspartoacylase
AVS46_RS15305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVS46_RS15325	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
AVS46_RS15340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AVS46_RS15345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVS46_RS15350	COG1733	regulation of RNA biosynthetic process
AVS46_RS15360	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AVS46_RS15365	COG0583	DNA-binding transcription factor activity
AVS46_RS15370	COG1597	lipid kinase activity
AVS46_RS15380	COG0671	phosphoesterase, PA-phosphatase related
AVS46_RS15410	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AVS46_RS15415	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVS46_RS15420	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVS46_RS15425	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVS46_RS15430	COG0649	NAD binding
AVS46_RS15435	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AVS46_RS15445	COG1034	ATP synthesis coupled electron transport
AVS46_RS15450	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AVS46_RS15455	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVS46_RS15465	COG0713	ATP synthesis coupled electron transport
AVS46_RS15480	COG1007	ATP synthesis coupled electron transport
AVS46_RS15490	COG4774	siderophore transport
AVS46_RS15495	COG4774	siderophore transport
AVS46_RS15510	COG0028	Belongs to the TPP enzyme family
AVS46_RS15515	COG3181	Tripartite tricarboxylate transporter family receptor
AVS46_RS15520	COG0583	DNA-binding transcription factor activity
AVS46_RS15525	COG0560	Phosphoserine phosphatase
AVS46_RS15530	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AVS46_RS15535	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AVS46_RS15540	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AVS46_RS15550	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AVS46_RS15555	COG0308	aminopeptidase N
AVS46_RS15575	COG0028	Belongs to the TPP enzyme family
AVS46_RS15595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVS46_RS15605	COG0318	PFAM AMP-dependent synthetase and ligase
AVS46_RS15615	COG1802	Transcriptional regulator
AVS46_RS15625	COG1802	Transcriptional regulator
AVS46_RS15635	COG1028	Short-chain dehydrogenase reductase Sdr
AVS46_RS15655	COG1126	abc transporter atp-binding protein
AVS46_RS15660	COG0765	amino acid transport
AVS46_RS15665	COG0765	amino acid transport
AVS46_RS15680	COG1538	Outer membrane efflux protein
AVS46_RS15685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVS46_RS15690	COG2274	protein secretion by the type I secretion system
AVS46_RS15695	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AVS46_RS15705	COG2994	toxin metabolic process
AVS46_RS15720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVS46_RS15725	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
AVS46_RS15735	COG0583	DNA-binding transcription factor activity
AVS46_RS15745	COG0142	geranyltranstransferase activity
AVS46_RS15755	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AVS46_RS15760	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AVS46_RS15765	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AVS46_RS15770	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AVS46_RS15815	COG3712	iron ion homeostasis
AVS46_RS15820	COG4774	siderophore transport
AVS46_RS15825	COG2353	YceI-like domain
AVS46_RS15840	COG0019	diaminopimelate decarboxylase activity
AVS46_RS15860	COG0747	negative chemotaxis
AVS46_RS15865	COG0601	transmembrane transport
AVS46_RS15870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVS46_RS15880	COG0154	amidase activity
AVS46_RS15885	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AVS46_RS15910	COG2154	pterin-4-alpha-carbinolamine dehydratase
AVS46_RS15920	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AVS46_RS15930	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AVS46_RS15935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AVS46_RS15940	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AVS46_RS15945	COG1929	Belongs to the glycerate kinase type-1 family
AVS46_RS15950	COG0469	pyruvate kinase activity
AVS46_RS15955	COG0700	Nucleoside recognition
AVS46_RS15990	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AVS46_RS15995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AVS46_RS16010	COG0823	Involved in the tonB-independent uptake of proteins
AVS46_RS16020	COG0848	biopolymer transport protein
AVS46_RS16025	COG0811	peptide transport
AVS46_RS16030	COG0824	Thioesterase
AVS46_RS16035	COG0442	prolyl-tRNA aminoacylation
AVS46_RS16040	COG0494	nUDIX hydrolase
AVS46_RS16055	COG2135	peptidase activity
AVS46_RS16125	COG1196	nuclear chromosome segregation
AVS46_RS16270	COG1464	Belongs to the NlpA lipoprotein family
AVS46_RS16300	COG4211	Belongs to the binding-protein-dependent transport system permease family
AVS46_RS16310	COG0154	amidase activity
AVS46_RS16315	COG0288	reversible hydration of carbon dioxide
AVS46_RS16330	COG0514	ATP-dependent DNA helicase (RecQ)
AVS46_RS16335	COG2255	four-way junction helicase activity
AVS46_RS16350	COG0632	four-way junction helicase activity
AVS46_RS16355	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AVS46_RS16375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVS46_RS16385	COG0006	proline dipeptidase activity
AVS46_RS16410	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AVS46_RS16425	COG4783	chaperone-mediated protein folding
AVS46_RS16430	COG0429	hydrolase of the alpha beta-hydrolase fold
AVS46_RS16460	COG0513	Belongs to the DEAD box helicase family
AVS46_RS16480	COG1058	Belongs to the CinA family
AVS46_RS16480	COG1546	Belongs to the CinA family
AVS46_RS16485	COG1414	Transcriptional regulator
AVS46_RS16505	COG0167	dihydroorotate dehydrogenase activity
AVS46_RS16510	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AVS46_RS16515	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AVS46_RS16525	COG0583	DNA-binding transcription factor activity
AVS46_RS16585	COG0280	phosphate acetyltransferase
AVS46_RS16585	COG0281	malic enzyme
AVS46_RS16595	COG0601	transmembrane transport
AVS46_RS16600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVS46_RS16605	COG4172	Belongs to the ABC transporter superfamily
AVS46_RS16635	COG0640	Transcriptional regulator
AVS46_RS16650	COG3135	benzoate transporter
AVS46_RS16655	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AVS46_RS16660	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AVS46_RS16665	COG0742	ribosomal rna small subunit methyltransferase
AVS46_RS16680	COG3639	organic phosphonate transmembrane transporter activity
AVS46_RS16685	COG3639	organic phosphonate transmembrane transporter activity
AVS46_RS16690	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AVS46_RS16725	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AVS46_RS16730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AVS46_RS16740	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AVS46_RS16745	COG1546	Belongs to the CinA family
AVS46_RS16745	COG1058	Belongs to the CinA family
AVS46_RS16750	COG0284	orotidine-5'-phosphate decarboxylase activity
AVS46_RS16755	COG1252	NADH dehydrogenase
AVS46_RS16770	COG3468	outer membrane autotransporter barrel domain protein
AVS46_RS16775	COG0459	protein refolding
AVS46_RS16780	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AVS46_RS16800	COG1053	succinate dehydrogenase
AVS46_RS16810	COG0583	DNA-binding transcription factor activity
AVS46_RS16815	COG1053	succinate dehydrogenase
AVS46_RS16835	COG3706	GGDEF domain
AVS46_RS16870	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AVS46_RS16875	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AVS46_RS16885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AVS46_RS16895	COG0069	glutamate synthase activity
AVS46_RS16900	COG2391	methyltransferase activity
AVS46_RS16905	COG0679	Auxin Efflux Carrier
AVS46_RS16930	COG0557	exoribonuclease II activity
AVS46_RS16935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AVS46_RS16945	COG3128	pkhd-type hydroxylase
AVS46_RS16950	COG0776	regulation of translation
AVS46_RS16980	COG0642	Histidine kinase
AVS46_RS16985	COG3158	transport of potassium into the cell
AVS46_RS16990	COG0137	argininosuccinate synthase activity
AVS46_RS16995	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AVS46_RS17000	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AVS46_RS17010	COG0583	DNA-binding transcription factor activity
AVS46_RS17020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AVS46_RS17040	COG2186	Transcriptional regulator
AVS46_RS17050	COG2223	nitrite transmembrane transporter activity
AVS46_RS17060	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AVS46_RS17065	COG0450	alkyl hydroperoxide reductase
AVS46_RS17085	COG1214	PFAM Peptidase M22, glycoprotease
AVS46_RS17090	COG1573	uracil-dna glycosylase
AVS46_RS17095	COG0477	Major facilitator Superfamily
AVS46_RS17100	COG1196	nuclear chromosome segregation
AVS46_RS17110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AVS46_RS17115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AVS46_RS17130	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AVS46_RS17135	COG1122	ATPase activity
AVS46_RS17140	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AVS46_RS17145	COG1268	BioY protein
AVS46_RS17165	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AVS46_RS17200	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AVS46_RS17205	COG2878	Part of a membrane complex involved in electron transport
AVS46_RS17220	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AVS46_RS17225	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AVS46_RS17230	COG0251	oxidation-reduction process
AVS46_RS17240	COG3228	Belongs to the MtfA family
AVS46_RS17245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AVS46_RS17255	COG0133	tryptophan synthase activity
AVS46_RS17260	COG0159	tryptophan synthase activity
AVS46_RS17265	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AVS46_RS17270	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AVS46_RS17285	COG1530	ribonuclease E activity
AVS46_RS17295	COG0546	phosphoglycolate phosphatase activity
AVS46_RS17300	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AVS46_RS17305	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AVS46_RS17315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AVS46_RS17320	COG0583	DNA-binding transcription factor activity
AVS46_RS17330	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AVS46_RS17350	COG0251	oxidation-reduction process
AVS46_RS17355	COG1017	nitric oxide dioxygenase activity
AVS46_RS17355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AVS46_RS17360	COG2031	fatty acid transporter
AVS46_RS17365	COG1012	belongs to the aldehyde dehydrogenase family
AVS46_RS17370	COG1802	Transcriptional regulator
AVS46_RS17380	COG1278	Cold shock
AVS46_RS17385	COG0583	DNA-binding transcription factor activity
AVS46_RS17405	COG0183	Belongs to the thiolase family
AVS46_RS17415	COG1960	acyl-CoA dehydrogenase activity
AVS46_RS17420	COG0583	DNA-binding transcription factor activity
AVS46_RS17425	COG3181	Tripartite tricarboxylate transporter family receptor
AVS46_RS17430	COG1024	Enoyl-CoA hydratase
AVS46_RS17435	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AVS46_RS17440	COG1253	flavin adenine dinucleotide binding
AVS46_RS17445	COG1285	pathogenesis
AVS46_RS17455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AVS46_RS17470	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AVS46_RS17480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AVS46_RS17490	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AVS46_RS17495	COG3181	Tripartite tricarboxylate transporter family receptor
AVS46_RS17500	COG1960	acyl-CoA dehydrogenase activity
AVS46_RS17520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AVS46_RS17525	COG1024	Enoyl-CoA hydratase
AVS46_RS17530	COG1960	acyl-CoA dehydrogenase activity
AVS46_RS17550	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AVS46_RS17555	COG0022	dehydrogenase e1 component
AVS46_RS17560	COG1024	Enoyl-CoA hydratase
AVS46_RS17565	COG0508	dehydrogenase complex catalyzes the overall conversion of
AVS46_RS17585	COG0683	leucine binding
AVS46_RS17590	COG0559	Belongs to the binding-protein-dependent transport system permease family
AVS46_RS17595	COG0411	ABC transporter
AVS46_RS17605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AVS46_RS17620	COG3181	Tripartite tricarboxylate transporter family receptor
AVS46_RS17645	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AVS46_RS17650	COG0793	Belongs to the peptidase S41A family
AVS46_RS17655	COG4942	peptidase
AVS46_RS17660	COG0588	phosphoglycerate mutase activity
AVS46_RS17665	COG1054	Belongs to the UPF0176 family
AVS46_RS17670	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AVS46_RS17675	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AVS46_RS17680	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AVS46_RS17685	COG3181	Tripartite tricarboxylate transporter family receptor
AVS46_RS17700	COG2226	methyltransferase
AVS46_RS17705	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AVS46_RS17720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVS46_RS17725	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AVS46_RS17750	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AVS46_RS17775	COG1335	isochorismatase
AVS46_RS17780	COG2309	aminopeptidase activity
AVS46_RS17785	COG0596	Alpha beta hydrolase
AVS46_RS17790	COG3473	Maleate cis-trans isomerase
AVS46_RS17800	COG2068	MobA-Related Protein
AVS46_RS17825	COG2204	response regulator
AVS46_RS17830	COG5000	phosphorelay sensor kinase activity
AVS46_RS17840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AVS46_RS17840	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AVS46_RS17850	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
AVS46_RS17880	COG0583	DNA-binding transcription factor activity
AVS46_RS17895	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AVS46_RS17900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AVS46_RS17905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVS46_RS17920	COG0758	DNA mediated transformation
AVS46_RS17925	COG1522	sequence-specific DNA binding
AVS46_RS17935	COG0242	peptide deformylase activity
AVS46_RS17950	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AVS46_RS17960	COG0546	phosphoglycolate phosphatase activity
AVS46_RS17980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AVS46_RS17985	COG1942	4-Oxalocrotonate Tautomerase
AVS46_RS17990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVS46_RS18015	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AVS46_RS18035	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AVS46_RS18040	COG1024	Enoyl-CoA hydratase
AVS46_RS18045	COG1414	Transcriptional regulator
AVS46_RS18050	COG0318	PFAM AMP-dependent synthetase and ligase
AVS46_RS18055	COG3181	Tripartite tricarboxylate transporter family receptor
AVS46_RS18085	COG0583	DNA-binding transcription factor activity
AVS46_RS18100	COG3422	double-strand break repair
AVS46_RS18105	COG0330	HflC and HflK could
AVS46_RS18115	COG0251	oxidation-reduction process
AVS46_RS18160	COG3723	Recombinational DNA repair protein, rece pathway
AVS46_RS18195	COG0582	viral genome integration into host DNA
AVS46_RS18220	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AVS46_RS18230	COG0706	membrane insertase activity
AVS46_RS18235	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AVS46_RS18240	COG0594	ribonuclease P activity
AVS46_RS18245	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AVS46_RS18250	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AVS46_RS18265	COG1414	Transcriptional regulator
AVS46_RS18270	COG0154	amidase activity
AVS46_RS18285	COG1304	FMN binding
AVS46_RS18305	COG1960	acyl-CoA dehydrogenase activity
AVS46_RS18325	COG1960	acyl-CoA dehydrogenase activity
AVS46_RS18340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AVS46_RS18355	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AVS46_RS18360	COG3181	Tripartite tricarboxylate transporter family receptor
AVS46_RS18370	COG2358	TRAP transporter, solute receptor (TAXI family
AVS46_RS18380	COG1629	transport
AVS46_RS18385	COG2922	Belongs to the Smg family
AVS46_RS18410	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AVS46_RS18415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVS46_RS18420	COG1028	Short-chain dehydrogenase reductase Sdr
AVS46_RS18425	COG1012	belongs to the aldehyde dehydrogenase family
AVS46_RS18435	COG0028	Belongs to the TPP enzyme family
AVS46_RS18440	COG1522	sequence-specific DNA binding
AVS46_RS18445	COG3781	membrane
AVS46_RS18455	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AVS46_RS18475	COG4206	TonB-dependent receptor
AVS46_RS18480	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AVS46_RS18485	COG2022	thiamine diphosphate biosynthetic process
AVS46_RS18490	COG0351	phosphomethylpyrimidine kinase
AVS46_RS18495	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AVS46_RS18510	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AVS46_RS18520	COG0628	permease
AVS46_RS18530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AVS46_RS18540	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AVS46_RS18545	COG0049	tRNA binding
AVS46_RS18550	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AVS46_RS18555	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AVS46_RS18560	COG0051	transcription antitermination factor activity, RNA binding
AVS46_RS18565	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AVS46_RS18570	COG0088	Forms part of the polypeptide exit tunnel
AVS46_RS18575	COG0089	rRNA binding
AVS46_RS18580	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AVS46_RS18585	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AVS46_RS18590	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AVS46_RS18595	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AVS46_RS18600	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AVS46_RS18605	COG0255	Belongs to the universal ribosomal protein uL29 family
AVS46_RS18610	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AVS46_RS18630	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AVS46_RS18635	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AVS46_RS18640	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AVS46_RS18645	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AVS46_RS18650	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AVS46_RS18655	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AVS46_RS18660	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AVS46_RS18665	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AVS46_RS18670	COG1841	ribosomal large subunit assembly
AVS46_RS18675	COG0200	Binds to the 23S rRNA
AVS46_RS18680	COG0201	protein transport
AVS46_RS18685	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AVS46_RS18690	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AVS46_RS18695	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AVS46_RS18700	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AVS46_RS18705	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AVS46_RS18710	COG0202	RNA polymerase activity
AVS46_RS18715	COG0203	ribosomal protein L17
AVS46_RS18720	COG0537	adenosine 5'-monophosphoramidase activity
AVS46_RS18725	COG1324	tolerance protein
AVS46_RS18730	COG4232	protein-disulfide reductase activity
AVS46_RS18745	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AVS46_RS18755	COG1333	cytochrome c biogenesis protein
AVS46_RS18760	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AVS46_RS18775	COG1965	Belongs to the frataxin family
AVS46_RS18785	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AVS46_RS18790	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AVS46_RS18795	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AVS46_RS18810	COG2814	Major facilitator Superfamily
AVS46_RS18815	COG0629	single-stranded DNA binding
AVS46_RS18855	COG0402	S-adenosylhomocysteine deaminase activity
AVS46_RS18865	COG0438	transferase activity, transferring glycosyl groups
AVS46_RS18885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVS46_RS18910	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AVS46_RS18915	COG2186	Transcriptional regulator
AVS46_RS18935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AVS46_RS18940	COG1956	GAF domain-containing protein
AVS46_RS18945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AVS46_RS18960	COG1652	LysM domain
AVS46_RS18975	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AVS46_RS18990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVS46_RS19020	COG3181	Tripartite tricarboxylate transporter family receptor
AVS46_RS19035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVS46_RS19050	COG1024	Enoyl-CoA hydratase
AVS46_RS19065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AVS46_RS19070	COG1309	transcriptional regulator
AVS46_RS19075	COG2816	NAD+ diphosphatase activity
AVS46_RS19080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AVS46_RS19165	COG2814	Major facilitator Superfamily
AVS46_RS19170	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AVS46_RS19190	COG1999	signal sequence binding
AVS46_RS19195	COG0109	protoheme IX farnesyltransferase activity
AVS46_RS19235	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AVS46_RS19255	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AVS46_RS19260	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AVS46_RS19275	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AVS46_RS19285	COG0070	glutamate synthase
AVS46_RS19285	COG0069	glutamate synthase activity
AVS46_RS19285	COG0067	glutamate synthase
AVS46_RS19295	COG3047	cAMP biosynthetic process
AVS46_RS19305	COG1127	ABC transporter
AVS46_RS19310	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AVS46_RS19315	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AVS46_RS19320	COG2853	Lipoprotein
AVS46_RS19330	COG1131	(ABC) transporter
AVS46_RS19335	COG0842	Transport permease protein
AVS46_RS19345	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AVS46_RS19350	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AVS46_RS19355	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AVS46_RS19360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AVS46_RS19365	COG0131	Imidazoleglycerol-phosphate dehydratase
AVS46_RS19370	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AVS46_RS19375	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AVS46_RS19380	COG0107	imidazoleglycerol-phosphate synthase activity
AVS46_RS19385	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AVS46_RS19390	COG0140	phosphoribosyl-ATP diphosphatase activity
AVS46_RS19395	COG0537	adenosine 5'-monophosphoramidase activity
AVS46_RS19400	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AVS46_RS19405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AVS46_RS19420	COG3181	Tripartite tricarboxylate transporter family receptor
AVS46_RS19455	COG3702	type iv secretory pathway
AVS46_RS19460	COG3451	type IV secretory pathway VirB4
AVS46_RS19475	COG3736	Type IV secretory pathway, component VirB8
AVS46_RS19480	COG3504	Conjugal transfer protein
AVS46_RS19485	COG2948	multi-organism process
AVS46_RS19490	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
AVS46_RS19500	COG0697	spore germination
AVS46_RS19520	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AVS46_RS19525	COG0747	negative chemotaxis
AVS46_RS19530	COG0601	transmembrane transport
AVS46_RS19535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVS46_RS19540	COG0444	Belongs to the ABC transporter superfamily
AVS46_RS19550	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AVS46_RS19560	COG0494	nUDIX hydrolase
AVS46_RS19595	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AVS46_RS19600	COG0237	dephospho-CoA kinase activity
AVS46_RS19605	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AVS46_RS19620	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AVS46_RS19625	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AVS46_RS19635	COG0477	Major facilitator Superfamily
AVS46_RS19640	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AVS46_RS19655	COG1126	abc transporter atp-binding protein
AVS46_RS19660	COG0765	amino acid transport
AVS46_RS19665	COG4597	amino acid ABC transporter
AVS46_RS19670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVS46_RS19675	COG2884	Cell division ATP-binding protein ftsE
AVS46_RS19680	COG2177	Part of the ABC transporter FtsEX involved in
AVS46_RS19685	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AVS46_RS19695	COG1194	a g-specific adenine glycosylase
AVS46_RS19705	COG2226	methyltransferase
AVS46_RS19715	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AVS46_RS19720	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AVS46_RS19735	COG1024	Enoyl-CoA hydratase
AVS46_RS19755	COG1024	Enoyl-CoA hydratase
AVS46_RS19760	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AVS46_RS19765	COG3181	Tripartite tricarboxylate transporter family receptor
AVS46_RS19775	COG0753	catalase activity
AVS46_RS19780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVS46_RS19785	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AVS46_RS19795	COG2175	clavaminate synthase activity
AVS46_RS19800	COG1473	amidohydrolase
AVS46_RS19805	COG4608	Belongs to the ABC transporter superfamily
AVS46_RS19810	COG0444	Belongs to the ABC transporter superfamily
AVS46_RS19825	COG0747	negative chemotaxis
AVS46_RS19830	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AVS46_RS19865	COG0436	Aminotransferase
AVS46_RS19870	COG1278	Cold shock