locus-tag	class	description
CXD84_RS00005	COG0445	tRNA wobble uridine modification
CXD84_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
CXD84_RS00015	COG1192	Involved in chromosome partitioning
CXD84_RS00025	COG1475	DNA binding
CXD84_RS00050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CXD84_RS00060	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CXD84_RS00070	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CXD84_RS00075	COG0081	regulation of translation
CXD84_RS00080	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CXD84_RS00085	COG0222	ribosome binding
CXD84_RS00090	COG0085	RNA polymerase activity
CXD84_RS00095	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CXD84_RS00135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD84_RS00160	COG1024	Enoyl-CoA hydratase
CXD84_RS00190	COG0752	glycyl-tRNA synthetase alpha subunit
CXD84_RS00195	COG0751	glycine-tRNA ligase activity
CXD84_RS00200	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CXD84_RS00205	COG0204	Acyl-transferase
CXD84_RS00220	COG0242	peptide deformylase activity
CXD84_RS00260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CXD84_RS00265	COG2813	Specifically methylates the guanine in position
CXD84_RS00265	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CXD84_RS00280	COG2223	nitrite transmembrane transporter activity
CXD84_RS00290	COG1794	racemase activity, acting on amino acids and derivatives
CXD84_RS00295	COG1126	abc transporter atp-binding protein
CXD84_RS00300	COG0765	amino acid transport
CXD84_RS00305	COG0765	amino acid transport
CXD84_RS00310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD84_RS00375	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CXD84_RS00405	COG0326	Molecular chaperone. Has ATPase activity
CXD84_RS00410	COG0625	glutathione transferase activity
CXD84_RS00425	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CXD84_RS00430	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CXD84_RS00460	COG0438	transferase activity, transferring glycosyl groups
CXD84_RS00465	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CXD84_RS00470	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CXD84_RS00500	COG0859	PFAM glycosyl transferase family 9
CXD84_RS00515	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CXD84_RS00525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CXD84_RS00530	COG1127	ABC transporter
CXD84_RS00550	COG1686	Belongs to the peptidase S11 family
CXD84_RS00560	COG2921	Belongs to the UPF0250 family
CXD84_RS00565	COG0321	lipoyl(octanoyl) transferase activity
CXD84_RS00570	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CXD84_RS00605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CXD84_RS00615	COG0018	arginyl-trna synthetase
CXD84_RS00635	COG0395	ABC-type sugar transport system, permease component
CXD84_RS00640	COG1175	transmembrane transport
CXD84_RS00645	COG1653	transport
CXD84_RS00650	COG3842	ATPase activity
CXD84_RS00655	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CXD84_RS00665	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CXD84_RS00685	COG1609	Transcriptional regulator
CXD84_RS00695	COG0154	amidase activity
CXD84_RS00700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CXD84_RS00710	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CXD84_RS00720	COG0583	DNA-binding transcription factor activity
CXD84_RS00740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CXD84_RS00755	COG1802	Transcriptional regulator
CXD84_RS00770	COG1024	Enoyl-CoA hydratase
CXD84_RS00780	COG3181	Tripartite tricarboxylate transporter family receptor
CXD84_RS00795	COG1984	allophanate hydrolase subunit 2
CXD84_RS00800	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CXD84_RS00810	COG0583	DNA-binding transcription factor activity
CXD84_RS00815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CXD84_RS00825	COG5002	protein histidine kinase activity
CXD84_RS00835	COG5002	protein histidine kinase activity
CXD84_RS00840	COG0745	RESPONSE REGULATOR receiver
CXD84_RS00845	COG2226	methyltransferase
CXD84_RS00860	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CXD84_RS00880	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CXD84_RS00890	COG0513	Belongs to the DEAD box helicase family
CXD84_RS00895	COG1280	lysine exporter protein (LysE YggA)
CXD84_RS00900	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CXD84_RS00940	COG1054	Belongs to the UPF0176 family
CXD84_RS00945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CXD84_RS00945	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CXD84_RS00955	COG0489	protein tyrosine kinase activity
CXD84_RS00970	COG0717	Belongs to the dCTP deaminase family
CXD84_RS01000	COG2081	HI0933 family
CXD84_RS01010	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CXD84_RS01020	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CXD84_RS01025	COG0509	glycine decarboxylation via glycine cleavage system
CXD84_RS01030	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CXD84_RS01030	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CXD84_RS01070	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CXD84_RS01085	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CXD84_RS01095	COG1414	Transcriptional regulator
CXD84_RS01100	COG1028	Short-chain dehydrogenase reductase Sdr
CXD84_RS01105	COG2031	fatty acid transporter
CXD84_RS01110	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXD84_RS01120	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CXD84_RS01125	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CXD84_RS01135	COG4257	antibiotic catabolic process
CXD84_RS01160	COG1012	belongs to the aldehyde dehydrogenase family
CXD84_RS01165	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CXD84_RS01170	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CXD84_RS01195	COG1028	Short-chain dehydrogenase reductase Sdr
CXD84_RS01205	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CXD84_RS01215	COG2188	Transcriptional regulator
CXD84_RS01220	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CXD84_RS01245	COG0617	tRNA 3'-terminal CCA addition
CXD84_RS01260	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CXD84_RS01265	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CXD84_RS01270	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CXD84_RS01275	COG0586	Pfam SNARE associated Golgi protein
CXD84_RS01280	COG0860	N-Acetylmuramoyl-L-alanine amidase
CXD84_RS01285	COG0802	atpase or kinase
CXD84_RS01290	COG0114	fumarate hydratase activity
CXD84_RS01300	COG3181	Tripartite tricarboxylate transporter family receptor
CXD84_RS01310	COG0405	Gamma-glutamyltransferase
CXD84_RS01315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD84_RS01350	COG1294	oxidase, subunit
CXD84_RS01360	COG4988	ABC transporter
CXD84_RS01365	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CXD84_RS01425	COG2969	positive regulation of protein catabolic process
CXD84_RS01430	COG0625	glutathione transferase activity
CXD84_RS01435	COG2857	Cytochrome c1
CXD84_RS01450	COG0723	plastoquinol--plastocyanin reductase activity
CXD84_RS01455	COG1970	mechanosensitive ion channel activity
CXD84_RS01460	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CXD84_RS01475	COG2808	Putative FMN-binding domain
CXD84_RS01480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CXD84_RS01485	COG0747	negative chemotaxis
CXD84_RS01490	COG0657	acetylesterase activity
CXD84_RS01500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CXD84_RS01505	COG2207	Transcriptional regulator
CXD84_RS01510	COG0129	dihydroxy-acid dehydratase activity
CXD84_RS01515	COG2814	Major facilitator Superfamily
CXD84_RS01520	COG0583	DNA-binding transcription factor activity
CXD84_RS01530	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
CXD84_RS01600	COG1024	Enoyl-CoA hydratase
CXD84_RS01630	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CXD84_RS01635	COG0352	thiamine-phosphate diphosphorylase activity
CXD84_RS01650	COG1678	Uncharacterized ACR, COG1678
CXD84_RS01655	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CXD84_RS01660	COG0540	Belongs to the ATCase OTCase family
CXD84_RS01675	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CXD84_RS01685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CXD84_RS01720	COG1234	tRNA 3'-trailer cleavage
CXD84_RS01740	COG3064	Membrane
CXD84_RS01770	COG1683	Conserved Protein
CXD84_RS01775	COG1120	ATPase activity
CXD84_RS01780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXD84_RS01785	COG4558	Periplasmic binding protein
CXD84_RS01790	COG3720	iron ion transport
CXD84_RS01800	COG3712	iron ion homeostasis
CXD84_RS01805	COG1595	DNA-templated transcription, initiation
CXD84_RS01840	COG1802	Transcriptional regulator
CXD84_RS01850	COG3069	C4-dicarboxylate transmembrane transporter activity
CXD84_RS01860	COG1012	belongs to the aldehyde dehydrogenase family
CXD84_RS01895	COG2860	membrane
CXD84_RS01900	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CXD84_RS01905	COG0708	Exodeoxyribonuclease III
CXD84_RS01910	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CXD84_RS01915	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CXD84_RS01920	COG0154	amidase activity
CXD84_RS01925	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CXD84_RS01930	COG1077	Cell shape determining protein MreB Mrl
CXD84_RS01935	COG1792	Involved in formation and maintenance of cell shape
CXD84_RS01945	COG0768	penicillin binding
CXD84_RS01950	COG0772	Belongs to the SEDS family
CXD84_RS01955	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CXD84_RS01960	COG0471	metal ion transport
CXD84_RS01965	COG1309	transcriptional regulator
CXD84_RS01975	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CXD84_RS01990	COG2823	Periplasmic or secreted lipoprotein
CXD84_RS01995	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CXD84_RS02010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CXD84_RS02030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD84_RS02040	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD84_RS02060	COG0492	ferredoxin-NADP+ reductase activity
CXD84_RS02070	COG3181	Tripartite tricarboxylate transporter family receptor
CXD84_RS02075	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXD84_RS02075	COG1024	Enoyl-CoA hydratase
CXD84_RS02080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD84_RS02085	COG0028	Belongs to the TPP enzyme family
CXD84_RS02110	COG3181	Tripartite tricarboxylate transporter family receptor
CXD84_RS02125	COG0697	spore germination
CXD84_RS02155	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CXD84_RS02160	COG0463	Glycosyl transferase, family 2
CXD84_RS02175	COG0786	glutamate:sodium symporter activity
CXD84_RS02185	COG2031	fatty acid transporter
CXD84_RS02200	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CXD84_RS02215	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CXD84_RS02230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXD84_RS02240	COG1285	pathogenesis
CXD84_RS02245	COG1253	flavin adenine dinucleotide binding
CXD84_RS02250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD84_RS02255	COG1024	Enoyl-CoA hydratase
CXD84_RS02260	COG3181	Tripartite tricarboxylate transporter family receptor
CXD84_RS02265	COG0583	DNA-binding transcription factor activity
CXD84_RS02270	COG1960	acyl-CoA dehydrogenase activity
CXD84_RS02280	COG0183	Belongs to the thiolase family
CXD84_RS02300	COG0583	DNA-binding transcription factor activity
CXD84_RS02305	COG1278	Cold shock
CXD84_RS02315	COG1802	Transcriptional regulator
CXD84_RS02320	COG1012	belongs to the aldehyde dehydrogenase family
CXD84_RS02325	COG2031	fatty acid transporter
CXD84_RS02330	COG1017	nitric oxide dioxygenase activity
CXD84_RS02330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CXD84_RS02335	COG0251	oxidation-reduction process
CXD84_RS02355	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD84_RS02365	COG0583	DNA-binding transcription factor activity
CXD84_RS02370	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD84_RS02395	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CXD84_RS02400	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CXD84_RS02405	COG0546	phosphoglycolate phosphatase activity
CXD84_RS02415	COG1530	ribonuclease E activity
CXD84_RS02435	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CXD84_RS02440	COG0159	tryptophan synthase activity
CXD84_RS02445	COG0133	tryptophan synthase activity
CXD84_RS02455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CXD84_RS02460	COG3228	Belongs to the MtfA family
CXD84_RS02470	COG0251	oxidation-reduction process
CXD84_RS02475	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CXD84_RS02480	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CXD84_RS02495	COG2878	Part of a membrane complex involved in electron transport
CXD84_RS02500	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CXD84_RS02535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CXD84_RS02555	COG1268	BioY protein
CXD84_RS02560	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CXD84_RS02565	COG1122	ATPase activity
CXD84_RS02570	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CXD84_RS02585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CXD84_RS02590	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CXD84_RS02600	COG1196	nuclear chromosome segregation
CXD84_RS02605	COG0477	Major facilitator Superfamily
CXD84_RS02610	COG1573	uracil-dna glycosylase
CXD84_RS02615	COG1214	PFAM Peptidase M22, glycoprotease
CXD84_RS02635	COG0450	alkyl hydroperoxide reductase
CXD84_RS02640	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CXD84_RS02650	COG2223	nitrite transmembrane transporter activity
CXD84_RS02660	COG2186	Transcriptional regulator
CXD84_RS02680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CXD84_RS02690	COG0583	DNA-binding transcription factor activity
CXD84_RS02700	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CXD84_RS02705	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CXD84_RS02710	COG0137	argininosuccinate synthase activity
CXD84_RS02715	COG3158	transport of potassium into the cell
CXD84_RS02720	COG0642	Histidine kinase
CXD84_RS02750	COG0776	regulation of translation
CXD84_RS02755	COG3128	pkhd-type hydroxylase
CXD84_RS02765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CXD84_RS02770	COG0557	exoribonuclease II activity
CXD84_RS02795	COG0679	Auxin Efflux Carrier
CXD84_RS02800	COG2391	methyltransferase activity
CXD84_RS02805	COG0069	glutamate synthase activity
CXD84_RS02815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXD84_RS02825	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CXD84_RS02865	COG3706	GGDEF domain
CXD84_RS02885	COG1053	succinate dehydrogenase
CXD84_RS02890	COG0583	DNA-binding transcription factor activity
CXD84_RS02905	COG1053	succinate dehydrogenase
CXD84_RS02925	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CXD84_RS02930	COG0459	protein refolding
CXD84_RS02935	COG3468	outer membrane autotransporter barrel domain protein
CXD84_RS02950	COG1252	NADH dehydrogenase
CXD84_RS02955	COG0284	orotidine-5'-phosphate decarboxylase activity
CXD84_RS02960	COG1546	Belongs to the CinA family
CXD84_RS02960	COG1058	Belongs to the CinA family
CXD84_RS02965	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CXD84_RS02975	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CXD84_RS02980	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CXD84_RS03020	COG3639	organic phosphonate transmembrane transporter activity
CXD84_RS03025	COG3639	organic phosphonate transmembrane transporter activity
CXD84_RS03045	COG0742	ribosomal rna small subunit methyltransferase
CXD84_RS03050	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CXD84_RS03055	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CXD84_RS03060	COG3135	benzoate transporter
CXD84_RS03075	COG0640	Transcriptional regulator
CXD84_RS03105	COG4172	Belongs to the ABC transporter superfamily
CXD84_RS03110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD84_RS03115	COG0601	transmembrane transport
CXD84_RS03125	COG0281	malic enzyme
CXD84_RS03125	COG0280	phosphate acetyltransferase
CXD84_RS03185	COG0583	DNA-binding transcription factor activity
CXD84_RS03200	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CXD84_RS03205	COG0167	dihydroorotate dehydrogenase activity
CXD84_RS03225	COG1414	Transcriptional regulator
CXD84_RS03230	COG1546	Belongs to the CinA family
CXD84_RS03230	COG1058	Belongs to the CinA family
CXD84_RS03250	COG0513	Belongs to the DEAD box helicase family
CXD84_RS03280	COG0429	hydrolase of the alpha beta-hydrolase fold
CXD84_RS03285	COG4783	chaperone-mediated protein folding
CXD84_RS03300	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CXD84_RS03325	COG0006	proline dipeptidase activity
CXD84_RS03335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CXD84_RS03355	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CXD84_RS03360	COG0632	four-way junction helicase activity
CXD84_RS03375	COG2255	four-way junction helicase activity
CXD84_RS03380	COG0514	ATP-dependent DNA helicase (RecQ)
CXD84_RS03395	COG0288	reversible hydration of carbon dioxide
CXD84_RS03400	COG0154	amidase activity
CXD84_RS03410	COG4211	Belongs to the binding-protein-dependent transport system permease family
CXD84_RS03440	COG1464	Belongs to the NlpA lipoprotein family
CXD84_RS03585	COG1196	nuclear chromosome segregation
CXD84_RS03660	COG2135	peptidase activity
CXD84_RS03675	COG0494	nUDIX hydrolase
CXD84_RS03680	COG0442	prolyl-tRNA aminoacylation
CXD84_RS03685	COG0824	Thioesterase
CXD84_RS03690	COG0811	peptide transport
CXD84_RS03695	COG0848	biopolymer transport protein
CXD84_RS03705	COG0823	Involved in the tonB-independent uptake of proteins
CXD84_RS03720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXD84_RS03725	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CXD84_RS03760	COG0700	Nucleoside recognition
CXD84_RS03765	COG0469	pyruvate kinase activity
CXD84_RS03770	COG1929	Belongs to the glycerate kinase type-1 family
CXD84_RS03775	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CXD84_RS03780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CXD84_RS03785	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CXD84_RS03795	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CXD84_RS03805	COG2154	pterin-4-alpha-carbinolamine dehydratase
CXD84_RS03830	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CXD84_RS03835	COG0154	amidase activity
CXD84_RS03845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD84_RS03850	COG0601	transmembrane transport
CXD84_RS03855	COG0747	negative chemotaxis
CXD84_RS03875	COG0019	diaminopimelate decarboxylase activity
CXD84_RS03890	COG2353	YceI-like domain
CXD84_RS03895	COG4774	siderophore transport
CXD84_RS03900	COG3712	iron ion homeostasis
CXD84_RS03945	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CXD84_RS03950	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CXD84_RS03955	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CXD84_RS03960	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CXD84_RS03970	COG0142	geranyltranstransferase activity
CXD84_RS03980	COG0583	DNA-binding transcription factor activity
CXD84_RS03990	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
CXD84_RS03995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD84_RS04015	COG2994	toxin metabolic process
CXD84_RS04025	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CXD84_RS04030	COG2274	protein secretion by the type I secretion system
CXD84_RS04035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CXD84_RS04040	COG1538	Outer membrane efflux protein
CXD84_RS04060	COG0765	amino acid transport
CXD84_RS04065	COG1126	abc transporter atp-binding protein
CXD84_RS04085	COG1028	Short-chain dehydrogenase reductase Sdr
CXD84_RS04095	COG1802	Transcriptional regulator
CXD84_RS04105	COG1802	Transcriptional regulator
CXD84_RS04115	COG0318	PFAM AMP-dependent synthetase and ligase
CXD84_RS04125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD84_RS04145	COG0028	Belongs to the TPP enzyme family
CXD84_RS04165	COG0308	aminopeptidase N
CXD84_RS04170	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CXD84_RS04185	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CXD84_RS04190	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CXD84_RS04195	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CXD84_RS04200	COG0560	Phosphoserine phosphatase
CXD84_RS04205	COG0583	DNA-binding transcription factor activity
CXD84_RS04210	COG3181	Tripartite tricarboxylate transporter family receptor
CXD84_RS04215	COG0028	Belongs to the TPP enzyme family
CXD84_RS04230	COG4774	siderophore transport
CXD84_RS04235	COG4774	siderophore transport
CXD84_RS04245	COG1007	ATP synthesis coupled electron transport
CXD84_RS04260	COG0713	ATP synthesis coupled electron transport
CXD84_RS04270	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CXD84_RS04275	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CXD84_RS04280	COG1034	ATP synthesis coupled electron transport
CXD84_RS04290	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CXD84_RS04295	COG0649	NAD binding
CXD84_RS04300	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CXD84_RS04305	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CXD84_RS04310	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CXD84_RS04315	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CXD84_RS04345	COG0671	phosphoesterase, PA-phosphatase related
CXD84_RS04355	COG1597	lipid kinase activity
CXD84_RS04360	COG0583	DNA-binding transcription factor activity
CXD84_RS04365	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CXD84_RS04375	COG1733	regulation of RNA biosynthetic process
CXD84_RS04380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CXD84_RS04385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CXD84_RS04400	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
CXD84_RS04420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD84_RS04440	COG3608	succinylglutamate desuccinylase aspartoacylase
CXD84_RS04445	COG0626	cystathionine gamma-synthase activity
CXD84_RS04450	COG0583	DNA-binding transcription factor activity
CXD84_RS04485	COG3799	methylaspartate ammonia-lyase activity
CXD84_RS04495	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CXD84_RS04505	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CXD84_RS04510	COG0149	triose-phosphate isomerase activity
CXD84_RS04530	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CXD84_RS04545	COG1185	polyribonucleotide nucleotidyltransferase activity
CXD84_RS04550	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CXD84_RS04565	COG1183	phosphatidylcholine synthase activity
CXD84_RS04570	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CXD84_RS04575	COG0440	acetolactate synthase activity
CXD84_RS04580	COG0028	Belongs to the TPP enzyme family
CXD84_RS04595	COG5265	(ABC) transporter
CXD84_RS04600	COG0500	methyltransferase
CXD84_RS04620	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CXD84_RS04650	COG0511	ligase activity, forming carbon-carbon bonds
CXD84_RS04675	COG2188	Transcriptional regulator
CXD84_RS04680	COG0439	Biotin carboxylase
CXD84_RS04730	COG5265	(ABC) transporter
CXD84_RS04740	COG0667	Aldo Keto reductase
CXD84_RS04755	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CXD84_RS04795	COG0165	Argininosuccinate lyase
CXD84_RS04800	COG0668	transmembrane transport
CXD84_RS04850	COG0747	negative chemotaxis
CXD84_RS04855	COG0601	transmembrane transport
CXD84_RS04870	COG1162	GTPase activity
CXD84_RS04875	COG0501	Belongs to the peptidase M48B family
CXD84_RS04880	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CXD84_RS04890	COG3327	negative regulation of DNA-templated transcription, initiation
CXD84_RS04895	COG3396	Phenylacetate-CoA oxygenase
CXD84_RS04900	COG3460	Phenylacetate-CoA oxygenase
CXD84_RS04905	COG3396	Phenylacetate-CoA oxygenase
CXD84_RS04910	COG2151	metal-sulfur cluster biosynthetic enzyme
CXD84_RS04930	COG1012	belongs to the aldehyde dehydrogenase family
CXD84_RS04935	COG1024	Enoyl-CoA hydratase
CXD84_RS04940	COG2050	protein possibly involved in aromatic compounds catabolism
CXD84_RS04950	COG3539	Fimbrial protein
CXD84_RS04970	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CXD84_RS04975	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CXD84_RS04975	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CXD84_RS04980	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CXD84_RS04985	COG0047	phosphoribosylformylglycinamidine synthase activity
CXD84_RS04985	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CXD84_RS04990	COG3210	domain, Protein
CXD84_RS04990	COG3064	Membrane
CXD84_RS04990	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CXD84_RS05020	COG0235	Class ii aldolase
CXD84_RS05025	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CXD84_RS05030	COG0720	synthase
CXD84_RS05035	COG0602	queuosine metabolic process
CXD84_RS05060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXD84_RS05095	COG3181	Tripartite tricarboxylate transporter family receptor
CXD84_RS05120	COG3842	ATPase activity
CXD84_RS05130	COG0395	ABC-type sugar transport system, permease component
CXD84_RS05160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD84_RS05165	COG0420	3'-5' exonuclease activity
CXD84_RS05210	COG0519	Catalyzes the synthesis of GMP from XMP
CXD84_RS05210	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CXD84_RS05225	COG3550	peptidyl-serine autophosphorylation
CXD84_RS05235	COG0477	Major facilitator Superfamily
CXD84_RS05250	COG1228	amidohydrolase
CXD84_RS05260	COG1116	anion transmembrane transporter activity
CXD84_RS05265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD84_RS05290	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CXD84_RS05310	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CXD84_RS05340	COG2814	Major facilitator Superfamily
CXD84_RS05355	COG1280	lysine exporter protein (LysE YggA)
CXD84_RS05370	COG0747	negative chemotaxis
CXD84_RS05375	COG0601	transmembrane transport
CXD84_RS05380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD84_RS05385	COG4172	Belongs to the ABC transporter superfamily
CXD84_RS05390	COG1609	Transcriptional regulator
CXD84_RS05420	COG0586	Pfam SNARE associated Golgi protein
CXD84_RS05435	COG0500	methyltransferase
CXD84_RS05450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXD84_RS05460	COG0756	dUTP diphosphatase activity
CXD84_RS05470	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CXD84_RS05475	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CXD84_RS05480	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CXD84_RS05485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CXD84_RS05485	COG0072	phenylalanine-tRNA ligase activity
CXD84_RS05490	COG0776	regulation of translation
CXD84_RS05555	COG0540	Belongs to the ATCase OTCase family
CXD84_RS05560	COG2974	May be involved in recombination
CXD84_RS05570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD84_RS05575	COG0583	DNA-binding transcription factor activity
CXD84_RS05595	COG1028	Short-chain dehydrogenase reductase Sdr
CXD84_RS05610	COG3842	ATPase activity
CXD84_RS05615	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXD84_RS05615	COG1024	Enoyl-CoA hydratase
CXD84_RS05635	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CXD84_RS05640	COG2137	regulation of response to DNA damage stimulus
CXD84_RS05650	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CXD84_RS05660	COG0045	succinate-CoA ligase (ADP-forming) activity
CXD84_RS05665	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CXD84_RS05670	COG0861	Integral membrane protein TerC family
CXD84_RS05675	COG0861	Integral membrane protein TerC family
CXD84_RS05680	COG0181	hydroxymethylbilane synthase activity
CXD84_RS05740	COG4964	Belongs to the GSP D family
CXD84_RS05765	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CXD84_RS05775	COG0583	DNA-binding transcription factor activity
CXD84_RS05785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD84_RS05790	COG4311	Sarcosine oxidase, delta subunit
CXD84_RS05795	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CXD84_RS05795	COG0446	pyridine nucleotide-disulphide oxidoreductase
CXD84_RS05830	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CXD84_RS05835	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CXD84_RS05840	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CXD84_RS05845	COG0735	belongs to the Fur family
CXD84_RS05850	COG0497	DNA recombination
CXD84_RS05855	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CXD84_RS05860	COG1420	regulation of RNA biosynthetic process
CXD84_RS05865	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CXD84_RS05875	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CXD84_RS05885	COG0443	Heat shock 70 kDa protein
CXD84_RS05895	COG0612	Peptidase, M16
CXD84_RS05915	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CXD84_RS05960	COG0745	RESPONSE REGULATOR receiver
CXD84_RS05970	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CXD84_RS05975	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CXD84_RS05980	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CXD84_RS05995	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CXD84_RS06010	COG1193	negative regulation of DNA recombination
CXD84_RS06015	COG0492	ferredoxin-NADP+ reductase activity
CXD84_RS06020	COG1674	ftsk spoiiie
CXD84_RS06025	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CXD84_RS06030	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CXD84_RS06035	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CXD84_RS06060	COG3706	GGDEF domain
CXD84_RS06080	COG2814	Major facilitator Superfamily
CXD84_RS06110	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CXD84_RS06125	COG1028	Short-chain dehydrogenase reductase Sdr
CXD84_RS06135	COG3022	response to hydroperoxide
CXD84_RS06175	COG2197	response regulator
CXD84_RS06180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CXD84_RS06185	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CXD84_RS06190	COG0189	ligase activity
CXD84_RS06200	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CXD84_RS06205	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CXD84_RS06220	COG2423	ornithine cyclodeaminase activity
CXD84_RS06230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD84_RS06235	COG0765	amino acid transport
CXD84_RS06240	COG0765	amino acid transport
CXD84_RS06245	COG1126	abc transporter atp-binding protein
CXD84_RS06300	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CXD84_RS06310	COG2944	sequence-specific DNA binding
CXD84_RS06320	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CXD84_RS06325	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CXD84_RS06330	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CXD84_RS06335	COG0009	L-threonylcarbamoyladenylate synthase
CXD84_RS06340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD84_RS06345	COG1414	Transcriptional regulator
CXD84_RS06360	COG0765	amino acid transport
CXD84_RS06365	COG1126	abc transporter atp-binding protein
CXD84_RS06370	COG0028	Belongs to the TPP enzyme family
CXD84_RS06385	COG0028	Belongs to the TPP enzyme family
CXD84_RS06390	COG0583	DNA-binding transcription factor activity
CXD84_RS06395	COG4974	Belongs to the 'phage' integrase family
CXD84_RS06400	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CXD84_RS06405	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CXD84_RS06420	COG1686	Belongs to the peptidase S11 family
CXD84_RS06430	COG2814	Major facilitator Superfamily
CXD84_RS06440	COG1074	ATP-dependent DNA helicase activity
CXD84_RS06450	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CXD84_RS06455	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CXD84_RS06460	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CXD84_RS06480	COG2321	neutral zinc metallopeptidase
CXD84_RS06485	COG0009	L-threonylcarbamoyladenylate synthase
CXD84_RS06530	COG3360	Dodecin
CXD84_RS06535	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CXD84_RS06540	COG2850	peptidyl-arginine hydroxylation
CXD84_RS06545	COG3539	Fimbrial protein
CXD84_RS06550	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CXD84_RS06555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXD84_RS06570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD84_RS06575	COG0765	amino acid transport
CXD84_RS06580	COG1126	abc transporter atp-binding protein
CXD84_RS06585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CXD84_RS06590	COG1758	RNA polymerase activity
CXD84_RS06595	COG0194	GDP metabolic process
CXD84_RS06600	COG3258	Cytochrome c
CXD84_RS06605	COG2863	cytochrome
CXD84_RS06610	COG1028	Short-chain dehydrogenase reductase Sdr
CXD84_RS06615	COG0791	NLP P60 protein
CXD84_RS06620	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CXD84_RS06640	COG1561	YicC-like family, N-terminal region
CXD84_RS06645	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CXD84_RS06665	COG2200	EAL domain
CXD84_RS06665	COG2199	diguanylate cyclase activity
CXD84_RS06670	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CXD84_RS06680	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CXD84_RS06685	COG0174	glutamine synthetase
CXD84_RS06695	COG2204	response regulator
CXD84_RS06700	COG0583	DNA-binding transcription factor activity
CXD84_RS06705	COG1741	Belongs to the pirin family
CXD84_RS06710	COG1741	Belongs to the pirin family
CXD84_RS06720	COG3842	ATPase activity
CXD84_RS06725	COG1178	ABC-type Fe3 transport system permease component
CXD84_RS06730	COG1840	ABC-type Fe3 transport system, periplasmic component
CXD84_RS06740	COG0583	DNA-binding transcription factor activity
CXD84_RS06750	COG0656	L-ascorbic acid biosynthetic process
CXD84_RS06765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CXD84_RS06770	COG0583	DNA-binding transcription factor activity
CXD84_RS06785	COG0783	Belongs to the Dps family
CXD84_RS06805	COG0463	Glycosyl transferase, family 2
CXD84_RS06825	COG0438	transferase activity, transferring glycosyl groups
CXD84_RS06840	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CXD84_RS06865	COG0300	oxidoreductase activity
CXD84_RS06910	COG0861	Integral membrane protein TerC family
CXD84_RS06915	COG1028	Short-chain dehydrogenase reductase Sdr
CXD84_RS06935	COG0714	Associated with various cellular activities
CXD84_RS06970	COG3119	arylsulfatase activity
CXD84_RS06995	COG2197	response regulator
CXD84_RS07005	COG2944	sequence-specific DNA binding
CXD84_RS07015	COG0625	glutathione transferase activity
CXD84_RS07045	COG0179	Fumarylacetoacetate (FAA) hydrolase
CXD84_RS07050	COG1028	Short-chain dehydrogenase reductase Sdr
CXD84_RS07095	COG0431	NADPH-dependent FMN reductase
CXD84_RS07125	COG1028	Short-chain dehydrogenase reductase Sdr
CXD84_RS07130	COG0583	DNA-binding transcription factor activity
CXD84_RS07150	COG2111	Na H antiporter
CXD84_RS07150	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CXD84_RS07155	COG1006	Multisubunit Na H antiporter MnhC subunit
CXD84_RS07160	COG0651	ATP synthesis coupled electron transport
CXD84_RS07165	COG1863	multisubunit Na H antiporter MnhE subunit
CXD84_RS07170	COG2212	antiporter activity
CXD84_RS07195	COG0590	tRNA wobble adenosine to inosine editing
CXD84_RS07200	COG1619	proteins homologs of microcin C7 resistance protein MccF
CXD84_RS07205	COG1024	Enoyl-CoA hydratase
CXD84_RS07220	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CXD84_RS07225	COG0488	(ABC) transporter
CXD84_RS07260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CXD84_RS07270	COG2252	PERMEase
CXD84_RS07275	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CXD84_RS07285	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CXD84_RS07290	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CXD84_RS07320	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CXD84_RS07325	COG0789	Transcriptional regulator
CXD84_RS07335	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CXD84_RS07335	COG0678	peroxiredoxin activity
CXD84_RS07345	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CXD84_RS07350	COG0584	glycerophosphoryl diester phosphodiesterase
CXD84_RS07355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CXD84_RS07365	COG4181	ATPase activity
CXD84_RS07380	COG2823	Periplasmic or secreted lipoprotein
CXD84_RS07390	COG3237	CsbD-like
CXD84_RS07395	COG1181	Belongs to the D-alanine--D-alanine ligase family
CXD84_RS07395	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CXD84_RS07400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CXD84_RS07400	COG0189	ligase activity
CXD84_RS07420	COG2833	Protein of unknown function (DUF455)
CXD84_RS07425	COG2951	lytic endotransglycosylase activity
CXD84_RS07445	COG1522	sequence-specific DNA binding
CXD84_RS07455	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CXD84_RS07460	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CXD84_RS07465	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CXD84_RS07470	COG0196	riboflavin kinase activity
CXD84_RS07475	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CXD84_RS07495	COG0210	DNA helicase
CXD84_RS07500	COG4771	TonB-dependent receptor
CXD84_RS07505	COG0488	(ABC) transporter
CXD84_RS07510	COG2890	protein-(glutamine-N5) methyltransferase activity
CXD84_RS07515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CXD84_RS07520	COG2171	N-acyltransferase activity
CXD84_RS07555	COG1278	Cold shock
CXD84_RS07565	COG1278	Cold shock
CXD84_RS07575	COG0544	peptidyl-prolyl cis-trans isomerase activity
CXD84_RS07580	COG0740	serine-type endopeptidase activity
CXD84_RS07585	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CXD84_RS07590	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CXD84_RS07595	COG0583	DNA-binding transcription factor activity
CXD84_RS07600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD84_RS07615	COG1024	Enoyl-CoA hydratase
CXD84_RS07625	COG0183	Belongs to the thiolase family
CXD84_RS07630	COG1028	Short-chain dehydrogenase reductase Sdr
CXD84_RS07650	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CXD84_RS07680	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CXD84_RS07690	COG0556	nucleotide-excision repair
CXD84_RS07695	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CXD84_RS07705	COG1104	cysteine desulfurase activity
CXD84_RS07710	COG0822	iron-sulfur transferase activity
CXD84_RS07715	COG0316	Belongs to the HesB IscA family
CXD84_RS07720	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CXD84_RS07725	COG0443	Heat shock 70 kDa protein
CXD84_RS07730	COG0633	Ferredoxin
CXD84_RS07750	COG1024	Enoyl-CoA hydratase
CXD84_RS07775	COG3395	kinase activity
CXD84_RS07795	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CXD84_RS07805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD84_RS07835	COG0747	negative chemotaxis
CXD84_RS07840	COG0601	transmembrane transport
CXD84_RS07845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD84_RS07850	COG4172	Belongs to the ABC transporter superfamily
CXD84_RS07855	COG0154	amidase activity
CXD84_RS07900	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CXD84_RS07905	COG0425	Belongs to the sulfur carrier protein TusA family
CXD84_RS07915	COG0228	four-way junction DNA binding
CXD84_RS07920	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CXD84_RS07925	COG0336	Belongs to the RNA methyltransferase TrmD family
CXD84_RS07930	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CXD84_RS07950	COG0642	Histidine kinase
CXD84_RS07965	COG0525	valine-tRNA ligase activity
CXD84_RS07970	COG0105	UTP biosynthetic process
CXD84_RS07975	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CXD84_RS07985	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CXD84_RS07990	COG0124	histidyl-tRNA synthetase
CXD84_RS07995	COG2976	Protein conserved in bacteria
CXD84_RS08000	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CXD84_RS08005	COG1160	GTP binding
CXD84_RS08010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CXD84_RS08015	COG1923	regulation of RNA biosynthetic process
CXD84_RS08020	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CXD84_RS08025	COG0330	HflC and HflK could
CXD84_RS08030	COG0330	HflC and HflK could
CXD84_RS08035	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CXD84_RS08040	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CXD84_RS08045	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CXD84_RS08050	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CXD84_RS08065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CXD84_RS08095	COG0628	permease
CXD84_RS08100	COG0842	Transport permease protein
CXD84_RS08105	COG1131	(ABC) transporter
CXD84_RS08175	COG0156	8-amino-7-oxononanoate synthase activity
CXD84_RS08185	COG4106	trans-aconitate 2-methyltransferase activity
CXD84_RS08185	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CXD84_RS08190	COG1380	Effector of murein hydrolase LrgA
CXD84_RS08210	COG3284	Transcriptional regulator
CXD84_RS08215	COG1012	belongs to the aldehyde dehydrogenase family
CXD84_RS08230	COG2733	membrane
CXD84_RS08235	COG0583	DNA-binding transcription factor activity
CXD84_RS08240	COG0384	phenazine biosynthesis protein PhzF
CXD84_RS08245	COG5507	3-demethylubiquinone-9 3-methyltransferase
CXD84_RS08250	COG2169	Transcriptional regulator
CXD84_RS08280	COG0659	secondary active sulfate transmembrane transporter activity
CXD84_RS08305	COG1132	(ABC) transporter
CXD84_RS08355	COG2207	Transcriptional regulator
CXD84_RS08495	COG2346	COG2346, Truncated hemoglobins
CXD84_RS08525	COG0583	DNA-binding transcription factor activity
CXD84_RS08540	COG0183	Belongs to the thiolase family
CXD84_RS08555	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD84_RS08560	COG0633	Ferredoxin
CXD84_RS08570	COG1024	Enoyl-CoA hydratase
CXD84_RS08580	COG4638	Rieske (2fe-2S)
CXD84_RS08590	COG0559	Belongs to the binding-protein-dependent transport system permease family
CXD84_RS08610	COG2224	Isocitrate lyase
CXD84_RS08615	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CXD84_RS08615	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CXD84_RS08625	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CXD84_RS08630	COG0322	excinuclease ABC activity
CXD84_RS08635	COG1472	Belongs to the glycosyl hydrolase 3 family
CXD84_RS08640	COG0736	holo-[acyl-carrier-protein] synthase activity
CXD84_RS08645	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CXD84_RS08655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CXD84_RS08660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CXD84_RS08685	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CXD84_RS08700	COG2032	superoxide dismutase activity
CXD84_RS08715	COG1024	Enoyl-CoA hydratase
CXD84_RS08725	COG1802	Transcriptional regulator
CXD84_RS08735	COG0183	Belongs to the thiolase family
CXD84_RS08740	COG1942	4-Oxalocrotonate Tautomerase
CXD84_RS08750	COG4176	ABC-type proline glycine betaine transport system permease component
CXD84_RS08770	COG2814	Major facilitator Superfamily
CXD84_RS08775	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CXD84_RS08780	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CXD84_RS08810	COG2814	Major facilitator Superfamily
CXD84_RS08815	COG0495	leucyl-tRNA aminoacylation
CXD84_RS08830	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CXD84_RS08840	COG0154	amidase activity
CXD84_RS08845	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXD84_RS08900	COG0427	acetyl-CoA hydrolase
CXD84_RS08905	COG0583	DNA-binding transcription factor activity
CXD84_RS08925	COG0730	response to heat
CXD84_RS08930	COG0697	spore germination
CXD84_RS08965	COG2885	chlorophyll binding
CXD84_RS08995	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CXD84_RS09000	COG3384	dioxygenase
CXD84_RS09015	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CXD84_RS09020	COG3474	cytochrome
CXD84_RS09030	COG1595	DNA-templated transcription, initiation
CXD84_RS09045	COG2204	response regulator
CXD84_RS09085	COG4964	Belongs to the GSP D family
CXD84_RS09140	COG1846	Transcriptional regulator
CXD84_RS09145	COG4172	Belongs to the ABC transporter superfamily
CXD84_RS09150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD84_RS09155	COG0601	transmembrane transport
CXD84_RS09160	COG0747	negative chemotaxis
CXD84_RS09170	COG0598	Magnesium transport protein CorA
CXD84_RS09175	COG0210	DNA helicase
CXD84_RS09190	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CXD84_RS09195	COG1012	belongs to the aldehyde dehydrogenase family
CXD84_RS09200	COG0483	inositol monophosphate 1-phosphatase activity
CXD84_RS09205	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CXD84_RS09215	COG1045	serine acetyltransferase
CXD84_RS09220	COG0166	Belongs to the GPI family
CXD84_RS09235	COG2197	response regulator
CXD84_RS09245	COG3181	Tripartite tricarboxylate transporter family receptor
CXD84_RS09260	COG1017	nitric oxide dioxygenase activity
CXD84_RS09260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CXD84_RS09275	COG1335	isochorismatase
CXD84_RS09280	COG2309	aminopeptidase activity
CXD84_RS09295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CXD84_RS09300	COG2080	2 iron, 2 sulfur cluster binding
CXD84_RS09335	COG1846	Transcriptional regulator
CXD84_RS09355	COG1649	PFAM Uncharacterised BCR, COG1649
CXD84_RS09355	COG0726	polysaccharide deacetylase
CXD84_RS09360	COG1215	transferase activity, transferring glycosyl groups
CXD84_RS09370	COG1902	pentaerythritol trinitrate reductase activity
CXD84_RS09395	COG0251	oxidation-reduction process
CXD84_RS09405	COG1832	CoA-binding protein
CXD84_RS09410	COG1414	Transcriptional regulator
CXD84_RS09415	COG1902	pentaerythritol trinitrate reductase activity
CXD84_RS09415	COG0446	pyridine nucleotide-disulphide oxidoreductase
CXD84_RS09425	COG3842	ATPase activity
CXD84_RS09450	COG0583	DNA-binding transcription factor activity
CXD84_RS09460	COG1028	Short-chain dehydrogenase reductase Sdr
CXD84_RS09465	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CXD84_RS09470	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CXD84_RS09485	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CXD84_RS09485	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CXD84_RS09490	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXD84_RS09515	COG0527	aspartate kinase activity
CXD84_RS09520	COG0037	tRNA processing
CXD84_RS09530	COG0825	malonyl-CoA metabolic process
CXD84_RS09540	COG0215	cysteine-tRNA ligase activity
CXD84_RS09555	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CXD84_RS09560	COG1968	undecaprenyl-diphosphatase activity
CXD84_RS09565	COG1253	flavin adenine dinucleotide binding
CXD84_RS09570	COG0483	inositol monophosphate 1-phosphatase activity
CXD84_RS09590	COG0668	transmembrane transport
CXD84_RS09640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CXD84_RS09655	COG2831	hemolysin activation secretion protein
CXD84_RS09660	COG3539	Fimbrial protein
CXD84_RS09665	COG3188	usher protein
CXD84_RS09670	COG3121	Chaperone
CXD84_RS09690	COG2197	response regulator
CXD84_RS09695	COG2205	protein histidine kinase activity
CXD84_RS09695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD84_RS09705	COG4336	lyase activity
CXD84_RS09755	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CXD84_RS09765	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CXD84_RS09765	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CXD84_RS09775	COG0028	Belongs to the TPP enzyme family
CXD84_RS09790	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CXD84_RS09800	COG1126	abc transporter atp-binding protein
CXD84_RS09810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD84_RS09825	COG0084	hydrolase, TatD family'
CXD84_RS09830	COG0084	hydrolase, TatD family'
CXD84_RS09835	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CXD84_RS09840	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CXD84_RS09845	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CXD84_RS09865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD84_RS09870	COG1959	2 iron, 2 sulfur cluster binding
CXD84_RS09875	COG1017	nitric oxide dioxygenase activity
CXD84_RS09875	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CXD84_RS09905	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CXD84_RS09910	COG2358	TRAP transporter, solute receptor (TAXI family
CXD84_RS09945	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXD84_RS09950	COG1366	Belongs to the anti-sigma-factor antagonist family
CXD84_RS09955	COG2172	sigma factor antagonist activity
CXD84_RS09960	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CXD84_RS09970	COG2208	phosphoserine phosphatase activity
CXD84_RS09970	COG2770	Histidine kinase
CXD84_RS09995	COG1595	DNA-templated transcription, initiation
CXD84_RS10010	COG4792	protein secretion
CXD84_RS10015	COG4791	protein targeting
CXD84_RS10020	COG4794	Type iii secretion
CXD84_RS10025	COG4790	Type iii secretion
CXD84_RS10060	COG4669	(LipO)protein
CXD84_RS10125	COG4789	Type iii secretion
CXD84_RS10155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CXD84_RS10160	COG0840	transmembrane signaling receptor activity
CXD84_RS10165	COG2233	PERMEase
CXD84_RS10190	COG1840	ABC-type Fe3 transport system, periplasmic component
CXD84_RS10195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CXD84_RS10200	COG1178	ABC-type Fe3 transport system permease component
CXD84_RS10205	COG3842	ATPase activity
CXD84_RS10210	COG0583	DNA-binding transcription factor activity
CXD84_RS10230	COG0501	Belongs to the peptidase M48B family
CXD84_RS10240	COG0697	spore germination
CXD84_RS10250	COG1846	Transcriptional regulator
CXD84_RS10260	COG1566	PFAM secretion protein HlyD family protein
CXD84_RS10265	COG2814	Major facilitator Superfamily
CXD84_RS10270	COG0473	3-isopropylmalate dehydrogenase activity
CXD84_RS10280	COG0747	negative chemotaxis
CXD84_RS10290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD84_RS10305	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CXD84_RS10330	COG1012	belongs to the aldehyde dehydrogenase family
CXD84_RS10340	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CXD84_RS10345	COG1115	amino acid carrier protein
CXD84_RS10350	COG0433	COG0433 Predicted ATPase
CXD84_RS10355	COG0217	transcriptional regulatory protein
CXD84_RS10360	COG0151	Belongs to the GarS family
CXD84_RS10365	COG0408	coproporphyrinogen oxidase activity
CXD84_RS10370	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CXD84_RS10375	COG0799	negative regulation of ribosome biogenesis
CXD84_RS10380	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CXD84_RS10385	COG0424	maF-like protein
CXD84_RS10390	COG3468	outer membrane autotransporter barrel domain protein
CXD84_RS10430	COG1530	ribonuclease E activity
CXD84_RS10435	COG0077	Prephenate dehydratase
CXD84_RS10450	COG1132	(ABC) transporter
CXD84_RS10455	COG0859	PFAM glycosyl transferase family 9
CXD84_RS10480	COG2194	sulfuric ester hydrolase activity
CXD84_RS10485	COG0438	transferase activity, transferring glycosyl groups
CXD84_RS10490	COG0463	Glycosyl transferase, family 2
CXD84_RS10495	COG0726	polysaccharide deacetylase
CXD84_RS10500	COG0438	transferase activity, transferring glycosyl groups
CXD84_RS10515	COG1643	Atp-dependent helicase
CXD84_RS10520	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CXD84_RS10520	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CXD84_RS10525	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CXD84_RS10535	COG0704	Plays a role in the regulation of phosphate uptake
CXD84_RS10540	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CXD84_RS10545	COG1960	acyl-CoA dehydrogenase activity
CXD84_RS10570	COG1177	transmembrane transport
CXD84_RS10575	COG1176	ABC-type spermidine putrescine transport system, permease component I
CXD84_RS10580	COG3842	ATPase activity
CXD84_RS10585	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CXD84_RS10600	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CXD84_RS10605	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CXD84_RS10615	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CXD84_RS10615	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CXD84_RS10630	COG0372	Belongs to the citrate synthase family
CXD84_RS10635	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CXD84_RS10640	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CXD84_RS10645	COG1053	succinate dehydrogenase
CXD84_RS10650	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CXD84_RS10655	COG2009	succinate dehydrogenase
CXD84_RS10660	COG2188	Transcriptional regulator
CXD84_RS10665	COG0039	L-malate dehydrogenase activity
CXD84_RS10695	COG1981	membrane
CXD84_RS10720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CXD84_RS10730	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CXD84_RS10760	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CXD84_RS10765	COG0148	phosphopyruvate hydratase activity
CXD84_RS10775	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CXD84_RS10780	COG0504	CTP synthase activity
CXD84_RS10805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD84_RS10815	COG0747	negative chemotaxis
CXD84_RS10820	COG4172	Belongs to the ABC transporter superfamily
CXD84_RS10825	COG1446	asparaginase
CXD84_RS10855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CXD84_RS10870	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CXD84_RS10875	COG0697	spore germination
CXD84_RS10880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CXD84_RS10890	COG3193	protein, possibly involved in utilization of glycolate and propanediol
CXD84_RS10900	COG0791	NLP P60 protein
CXD84_RS10915	COG0583	DNA-binding transcription factor activity
CXD84_RS10930	COG0583	DNA-binding transcription factor activity
CXD84_RS10940	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CXD84_RS10955	COG0670	Belongs to the BI1 family
CXD84_RS10960	COG3181	Tripartite tricarboxylate transporter family receptor
CXD84_RS10975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CXD84_RS10985	COG1381	Involved in DNA repair and RecF pathway recombination
CXD84_RS10990	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CXD84_RS10995	COG0571	ribonuclease III activity
CXD84_RS11000	COG0681	Belongs to the peptidase S26 family
CXD84_RS11005	COG0481	GTPase activity
CXD84_RS11010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CXD84_RS11035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CXD84_RS11040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CXD84_RS11055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CXD84_RS11060	COG0416	fatty acid biosynthetic process
CXD84_RS11065	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CXD84_RS11070	COG1399	metal-binding, possibly nucleic acid-binding protein
CXD84_RS11075	COG0424	maF-like protein
CXD84_RS11085	COG3023	N-Acetylmuramoyl-L-alanine amidase
CXD84_RS11100	COG3022	response to hydroperoxide
CXD84_RS11115	COG0135	phosphoribosylanthranilate isomerase activity
CXD84_RS11130	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CXD84_RS11135	COG0101	tRNA pseudouridine synthase activity
CXD84_RS11145	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CXD84_RS11150	COG0473	3-isopropylmalate dehydrogenase activity
CXD84_RS11155	COG0066	3-isopropylmalate dehydratase activity
CXD84_RS11160	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CXD84_RS11170	COG1122	ATPase activity
CXD84_RS11205	COG0243	molybdopterin cofactor binding
CXD84_RS11205	COG3383	formate dehydrogenase (NAD+) activity
CXD84_RS11235	COG0489	protein tyrosine kinase activity
CXD84_RS11240	COG0746	molybdenum cofactor guanylyltransferase activity
CXD84_RS11245	COG0303	'Molybdopterin
CXD84_RS11250	COG1763	Mo-molybdopterin cofactor biosynthetic process
CXD84_RS11260	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CXD84_RS11265	COG5001	Diguanylate cyclase
CXD84_RS11285	COG3842	ATPase activity
CXD84_RS11295	COG0406	alpha-ribazole phosphatase activity
CXD84_RS11305	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CXD84_RS11310	COG0505	Belongs to the CarA family
CXD84_RS11315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CXD84_RS11345	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CXD84_RS11350	COG1960	acyl-CoA dehydrogenase activity
CXD84_RS11360	COG2867	negative regulation of translational initiation
CXD84_RS11370	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CXD84_RS11375	COG3706	GGDEF domain
CXD84_RS11380	COG0330	HflC and HflK could
CXD84_RS11395	COG0519	Catalyzes the synthesis of GMP from XMP
CXD84_RS11395	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CXD84_RS11405	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CXD84_RS11410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CXD84_RS11415	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CXD84_RS11420	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CXD84_RS11430	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CXD84_RS11435	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CXD84_RS11440	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CXD84_RS11445	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CXD84_RS11450	COG0750	zinc metalloprotease
CXD84_RS11455	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CXD84_RS11465	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CXD84_RS11470	COG0233	cytoplasmic translational termination
CXD84_RS11475	COG0528	UMP kinase activity
CXD84_RS11480	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CXD84_RS11485	COG0052	Belongs to the universal ribosomal protein uS2 family
CXD84_RS11490	COG0024	Methionine aminopeptidase
CXD84_RS11495	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CXD84_RS11525	COG0285	dihydrofolate synthase activity
CXD84_RS11565	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CXD84_RS11575	COG1677	Flagellar hook-basal body complex protein FliE
CXD84_RS11585	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CXD84_RS11595	COG1157	protein secretion by the type III secretion system
CXD84_RS11620	COG1580	Controls the rotational direction of flagella during chemotaxis
CXD84_RS11640	COG1338	Plays a role in the flagellum-specific transport system
CXD84_RS11660	COG0840	transmembrane signaling receptor activity
CXD84_RS11665	COG0840	transmembrane signaling receptor activity
CXD84_RS11670	COG0840	transmembrane signaling receptor activity
CXD84_RS11680	COG1256	bacterial-type flagellum assembly
CXD84_RS11690	COG1706	bacterial-type flagellum-dependent cell motility
CXD84_RS11695	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CXD84_RS11710	COG1749	Flagellar hook protein flgE
CXD84_RS11720	COG1558	bacterial-type flagellum-dependent cell motility
CXD84_RS11725	COG1815	bacterial-type flagellum-dependent cell motility
CXD84_RS11765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD84_RS11770	COG0765	amino acid transport
CXD84_RS11775	COG1126	abc transporter atp-binding protein
CXD84_RS11795	COG4948	Mandelate Racemase Muconate Lactonizing
CXD84_RS11800	COG3181	Tripartite tricarboxylate transporter family receptor
CXD84_RS11810	COG0066	3-isopropylmalate dehydratase activity
CXD84_RS11825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD84_RS11835	COG3181	Tripartite tricarboxylate transporter family receptor
CXD84_RS11845	COG1802	Transcriptional regulator
CXD84_RS11860	COG0583	DNA-binding transcription factor activity
CXD84_RS11880	COG1695	Transcriptional regulator
CXD84_RS11890	COG3568	Endonuclease Exonuclease Phosphatase
CXD84_RS11895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXD84_RS11945	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CXD84_RS11955	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CXD84_RS11975	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CXD84_RS12005	COG0667	Aldo Keto reductase
CXD84_RS12020	COG2259	Doxx family
CXD84_RS12050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD84_RS12070	COG0386	Belongs to the glutathione peroxidase family
CXD84_RS12075	COG0625	glutathione transferase activity
CXD84_RS12090	COG0095	Lipoate-protein ligase
CXD84_RS12105	COG0688	phosphatidylethanolamine metabolic process
CXD84_RS12115	COG1464	Belongs to the NlpA lipoprotein family
CXD84_RS12130	COG2363	Small membrane protein
CXD84_RS12155	COG3842	ATPase activity
CXD84_RS12160	COG0395	ABC-type sugar transport system, permease component
CXD84_RS12165	COG1175	transmembrane transport
CXD84_RS12170	COG1653	transport
CXD84_RS12180	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CXD84_RS12200	COG0559	Belongs to the binding-protein-dependent transport system permease family
CXD84_RS12220	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CXD84_RS12245	COG2311	Membrane
CXD84_RS12270	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CXD84_RS12280	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CXD84_RS12285	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CXD84_RS12290	COG1760	l-serine dehydratase
CXD84_RS12295	COG1283	sodium-dependent phosphate transmembrane transporter activity
CXD84_RS12300	COG0412	Dienelactone hydrolase
CXD84_RS12315	COG1611	Belongs to the LOG family
CXD84_RS12335	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CXD84_RS12340	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CXD84_RS12345	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CXD84_RS12350	COG0195	Participates in both transcription termination and antitermination
CXD84_RS12350	COG2251	uridine kinase activity
CXD84_RS12355	COG0779	Required for maturation of 30S ribosomal subunits
CXD84_RS12360	COG1187	pseudouridine synthase activity
CXD84_RS12365	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CXD84_RS12375	COG0583	DNA-binding transcription factor activity
CXD84_RS12385	COG0523	cobalamin synthesis protein
CXD84_RS12405	COG0625	glutathione transferase activity
CXD84_RS12410	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CXD84_RS12415	COG1047	Peptidyl-prolyl cis-trans
CXD84_RS12420	COG2003	Belongs to the UPF0758 family
CXD84_RS12425	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CXD84_RS12430	COG3483	tryptophan 2,3-dioxygenase activity
CXD84_RS12435	COG0254	rRNA binding
CXD84_RS12445	COG0534	Mate efflux family protein
CXD84_RS12465	COG2304	oxidoreductase activity
CXD84_RS12485	COG1028	Short-chain dehydrogenase reductase Sdr
CXD84_RS12490	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CXD84_RS12495	COG1562	ergosterol biosynthetic process
CXD84_RS12500	COG1562	ergosterol biosynthetic process
CXD84_RS12505	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CXD84_RS12505	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CXD84_RS12510	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CXD84_RS12520	COG0842	Transport permease protein
CXD84_RS12525	COG1131	(ABC) transporter
CXD84_RS12545	COG1477	protein flavinylation
CXD84_RS12560	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CXD84_RS12575	COG5564	TIM-barrel signal transduction protein
CXD84_RS12580	COG5441	Belongs to the UPF0261 family
CXD84_RS12590	COG3468	outer membrane autotransporter barrel domain protein
CXD84_RS12610	COG0542	response to heat
CXD84_RS12615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CXD84_RS12630	COG0494	nUDIX hydrolase
CXD84_RS12635	COG3530	Putative quorum-sensing-regulated virulence factor
CXD84_RS12645	COG1595	DNA-templated transcription, initiation
CXD84_RS12650	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CXD84_RS12685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD84_RS12690	COG0765	amino acid transport
CXD84_RS12695	COG0765	amino acid transport
CXD84_RS12730	COG0672	)-iron permease
CXD84_RS12745	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
CXD84_RS12750	COG1028	Short-chain dehydrogenase reductase Sdr
CXD84_RS12755	COG3243	poly(R)-hydroxyalkanoic acid synthase
CXD84_RS12765	COG0564	pseudouridine synthase activity
CXD84_RS12775	COG1199	ATP-dependent helicase activity
CXD84_RS12780	COG2183	response to ionizing radiation
CXD84_RS12785	COG0180	Tryptophanyl-tRNA synthetase
CXD84_RS12810	COG3181	Tripartite tricarboxylate transporter family receptor
CXD84_RS12830	COG0583	DNA-binding transcription factor activity
CXD84_RS12835	COG1028	Short-chain dehydrogenase reductase Sdr
CXD84_RS12840	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CXD84_RS12845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CXD84_RS12850	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXD84_RS12855	COG0567	Dehydrogenase, E1 component
CXD84_RS12870	COG1522	sequence-specific DNA binding
CXD84_RS12880	COG0280	phosphate acetyltransferase
CXD84_RS12880	COG0281	malic enzyme
CXD84_RS12885	COG3539	Fimbrial protein
CXD84_RS12905	COG0613	PHP domain protein
CXD84_RS12915	COG0658	competence protein
CXD84_RS12915	COG2333	competence protein COMEC
CXD84_RS12940	COG0084	hydrolase, TatD family'
CXD84_RS12945	COG1136	(ABC) transporter
CXD84_RS12960	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CXD84_RS12970	COG1028	Short-chain dehydrogenase reductase Sdr
CXD84_RS12975	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CXD84_RS12990	COG1022	Amp-dependent synthetase and ligase
CXD84_RS13025	COG2205	protein histidine kinase activity
CXD84_RS13030	COG0745	RESPONSE REGULATOR receiver
CXD84_RS13035	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CXD84_RS13045	COG1295	ribonuclease BN
CXD84_RS13060	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CXD84_RS13090	COG1534	Rna-binding protein
CXD84_RS13095	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CXD84_RS13100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CXD84_RS13110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CXD84_RS13120	COG0248	Ppx GppA phosphatase
CXD84_RS13145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CXD84_RS13165	COG2732	(Barnase) inhibitor
CXD84_RS13175	COG0280	phosphate acetyltransferase
CXD84_RS13175	COG0281	malic enzyme
CXD84_RS13185	COG0436	Aminotransferase
CXD84_RS13195	COG0741	lytic transglycosylase activity
CXD84_RS13200	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CXD84_RS13225	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CXD84_RS13225	COG1648	precorrin-2 dehydrogenase activity
CXD84_RS13240	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CXD84_RS13245	COG2027	D-alanyl-D-alanine carboxypeptidase
CXD84_RS13250	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CXD84_RS13255	COG0343	queuine tRNA-ribosyltransferase activity
CXD84_RS13260	COG1862	Preprotein translocase
CXD84_RS13265	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CXD84_RS13270	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CXD84_RS13285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CXD84_RS13290	COG1702	phosphate starvation-inducible protein PhoH
CXD84_RS13295	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CXD84_RS13300	COG4535	Mg2 and Co2 transporter CorC
CXD84_RS13310	COG0667	Aldo Keto reductase
CXD84_RS13335	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CXD84_RS13340	COG0745	RESPONSE REGULATOR receiver
CXD84_RS13345	COG2201	protein-glutamate methylesterase activity
CXD84_RS13375	COG0840	transmembrane signaling receptor activity
CXD84_RS13390	COG0745	RESPONSE REGULATOR receiver
CXD84_RS13425	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CXD84_RS13435	COG0739	heme binding
CXD84_RS13445	COG0521	Mo-molybdopterin cofactor biosynthetic process
CXD84_RS13450	COG0306	phosphate transporter
CXD84_RS13455	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CXD84_RS13485	COG0625	glutathione transferase activity
CXD84_RS13500	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CXD84_RS13505	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CXD84_RS13510	COG0126	phosphoglycerate kinase activity
CXD84_RS13515	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CXD84_RS13520	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CXD84_RS13525	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CXD84_RS13540	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CXD84_RS13545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CXD84_RS13550	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXD84_RS13555	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CXD84_RS13565	COG4566	intracellular signal transduction
CXD84_RS13570	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CXD84_RS13575	COG0339	signal peptide processing
CXD84_RS13580	COG1999	signal sequence binding
CXD84_RS13610	COG1187	pseudouridine synthase activity
CXD84_RS13615	COG3161	chorismate lyase activity
CXD84_RS13630	COG0667	Aldo Keto reductase
CXD84_RS13640	COG0335	large ribosomal subunit rRNA binding
CXD84_RS13675	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CXD84_RS13695	COG0450	alkyl hydroperoxide reductase
CXD84_RS13700	COG1960	acyl-CoA dehydrogenase activity
CXD84_RS13715	COG0123	including yeast histone deacetylase and acetoin utilization protein
CXD84_RS13720	COG2951	lytic endotransglycosylase activity
CXD84_RS13735	COG1555	photosystem II stabilization
CXD84_RS13735	COG1596	polysaccharide export
CXD84_RS13740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CXD84_RS13745	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CXD84_RS13750	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CXD84_RS13770	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CXD84_RS13775	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CXD84_RS13780	COG0287	Prephenate dehydrogenase
CXD84_RS13790	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CXD84_RS13805	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CXD84_RS13815	COG2814	Major facilitator Superfamily
CXD84_RS13850	COG0583	DNA-binding transcription factor activity
CXD84_RS13870	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CXD84_RS13875	COG0303	'Molybdopterin
CXD84_RS13880	COG0521	Mo-molybdopterin cofactor biosynthetic process
CXD84_RS13895	COG0315	cyclic pyranopterin monophosphate synthase activity
CXD84_RS13905	COG0412	Dienelactone hydrolase
CXD84_RS13915	COG0678	peroxiredoxin activity
CXD84_RS13925	COG0697	spore germination
CXD84_RS13930	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CXD84_RS13955	COG0789	Transcriptional regulator
CXD84_RS13970	COG1028	Short-chain dehydrogenase reductase Sdr
CXD84_RS13980	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CXD84_RS13985	COG1845	cytochrome c oxidase, subunit III
CXD84_RS13990	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CXD84_RS14000	COG0477	Major facilitator Superfamily
CXD84_RS14035	COG1309	transcriptional regulator
CXD84_RS14040	COG2271	Major facilitator Superfamily
CXD84_RS14075	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CXD84_RS14075	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CXD84_RS14075	COG0506	proline dehydrogenase activity
CXD84_RS14085	COG3008	intermembrane lipid transfer
CXD84_RS14085	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CXD84_RS14090	COG2995	paraquat-inducible protein a
CXD84_RS14095	COG0542	response to heat
CXD84_RS14100	COG4953	penicillin-binding protein 1C
CXD84_RS14110	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CXD84_RS14115	COG1278	Cold shock
CXD84_RS14125	COG0183	Belongs to the thiolase family
CXD84_RS14130	COG0038	chloride channel
CXD84_RS14135	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CXD84_RS14140	COG1570	exodeoxyribonuclease VII activity
CXD84_RS14150	COG0811	peptide transport
CXD84_RS14155	COG0848	biopolymer transport protein
CXD84_RS14160	COG1663	tetraacyldisaccharide 4'-kinase activity
CXD84_RS14165	COG2835	tetraacyldisaccharide 4'-kinase activity
CXD84_RS14170	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CXD84_RS14175	COG0563	adenylate kinase activity
CXD84_RS14185	COG0728	peptidoglycan biosynthetic process
CXD84_RS14195	COG0268	Binds directly to 16S ribosomal RNA
CXD84_RS14215	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CXD84_RS14240	COG0436	Aminotransferase
CXD84_RS14245	COG3737	Protein of unknown function (DUF498/DUF598)
CXD84_RS14250	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CXD84_RS14255	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CXD84_RS14260	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CXD84_RS14270	COG0305	Participates in initiation and elongation during chromosome replication
CXD84_RS14280	COG0359	binds to the 23S rRNA
CXD84_RS14285	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CXD84_RS14290	COG2965	DNA replication, synthesis of RNA primer
CXD84_RS14295	COG0360	Binds together with S18 to 16S ribosomal RNA
CXD84_RS14300	COG1469	GTP cyclohydrolase I activity
CXD84_RS14305	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CXD84_RS14310	COG0142	geranyltranstransferase activity
CXD84_RS14315	COG1722	exodeoxyribonuclease VII activity
CXD84_RS14325	COG3181	Tripartite tricarboxylate transporter family receptor
CXD84_RS14345	COG2239	Acts as a magnesium transporter
CXD84_RS14355	COG2855	membrane
CXD84_RS14365	COG1473	amidohydrolase
CXD84_RS14370	COG0318	PFAM AMP-dependent synthetase and ligase
CXD84_RS14395	COG1501	Belongs to the glycosyl hydrolase 31 family
CXD84_RS14400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CXD84_RS14405	COG2011	ABC-type metal ion transport system permease component
CXD84_RS14425	COG1454	alcohol dehydrogenase
CXD84_RS14455	COG2186	Transcriptional regulator
CXD84_RS14460	COG3181	Tripartite tricarboxylate transporter family receptor
CXD84_RS14480	COG1175	transmembrane transport
CXD84_RS14485	COG0395	ABC-type sugar transport system, permease component
CXD84_RS14490	COG3842	ATPase activity
CXD84_RS14505	COG1653	transport
CXD84_RS14525	COG2818	Glycosylase
CXD84_RS14530	COG2982	Protein involved in outer membrane biogenesis
CXD84_RS14540	COG1309	transcriptional regulator
CXD84_RS14545	COG1028	Short-chain dehydrogenase reductase Sdr
CXD84_RS14605	COG0583	DNA-binding transcription factor activity
CXD84_RS14610	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CXD84_RS14615	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CXD84_RS14630	COG1028	Short-chain dehydrogenase reductase Sdr
CXD84_RS14635	COG0477	Major facilitator Superfamily
CXD84_RS14645	COG0583	DNA-binding transcription factor activity
CXD84_RS14650	COG1448	Aminotransferase
CXD84_RS14655	COG1418	mRNA catabolic process
CXD84_RS14680	COG1063	alcohol dehydrogenase
CXD84_RS14700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD84_RS14710	COG0318	PFAM AMP-dependent synthetase and ligase
CXD84_RS14720	COG1522	sequence-specific DNA binding
CXD84_RS14725	COG3181	Tripartite tricarboxylate transporter family receptor
CXD84_RS14730	COG0307	riboflavin synthase, alpha
CXD84_RS14735	COG0154	amidase activity
CXD84_RS14755	COG2807	transmembrane transport
CXD84_RS14760	COG0590	tRNA wobble adenosine to inosine editing
CXD84_RS14770	COG0583	DNA-binding transcription factor activity
CXD84_RS14805	COG0559	Belongs to the binding-protein-dependent transport system permease family
CXD84_RS14810	COG0251	oxidation-reduction process
CXD84_RS14815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CXD84_RS14825	COG1414	Transcriptional regulator
CXD84_RS14830	COG1028	Short-chain dehydrogenase reductase Sdr
CXD84_RS14845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD84_RS14860	COG1024	Enoyl-CoA hydratase
CXD84_RS14865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD84_RS14870	COG0154	amidase activity
CXD84_RS14910	COG3909	cytochrome
CXD84_RS14915	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CXD84_RS14920	COG0625	glutathione transferase activity
CXD84_RS14925	COG0730	response to heat
CXD84_RS14930	COG0482	sulfurtransferase activity
CXD84_RS14935	COG0583	DNA-binding transcription factor activity
CXD84_RS14975	COG2819	hydrolase of the alpha beta superfamily
CXD84_RS14980	COG0247	lactate metabolic process
CXD84_RS14985	COG0277	FAD linked oxidase domain protein
CXD84_RS14990	COG0277	FAD linked oxidase domain protein
CXD84_RS14995	COG0277	FAD linked oxidase domain protein
CXD84_RS15000	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CXD84_RS15000	COG3210	domain, Protein
CXD84_RS15000	COG3064	Membrane
CXD84_RS15000	COG3210	domain, Protein
CXD84_RS15000	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CXD84_RS15000	COG3064	Membrane
CXD84_RS15005	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CXD84_RS15010	COG0312	modulator of DNA gyrase
CXD84_RS15045	COG1666	GTP binding
CXD84_RS15090	COG3220	belongs to the UPF0276 family
CXD84_RS15110	COG0640	Transcriptional regulator
CXD84_RS15115	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CXD84_RS15120	COG1845	cytochrome c oxidase, subunit III
CXD84_RS15125	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CXD84_RS15135	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CXD84_RS15170	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD84_RS15175	COG0583	DNA-binding transcription factor activity
CXD84_RS15205	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CXD84_RS15205	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CXD84_RS15220	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CXD84_RS15225	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CXD84_RS15235	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CXD84_RS15250	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CXD84_RS15255	COG0316	Belongs to the HesB IscA family
CXD84_RS15265	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CXD84_RS15270	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CXD84_RS15275	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CXD84_RS15280	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CXD84_RS15285	COG0312	modulator of DNA gyrase
CXD84_RS15290	COG3028	Belongs to the UPF0307 family
CXD84_RS15305	COG1116	anion transmembrane transporter activity
CXD84_RS15310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD84_RS15315	COG1335	isochorismatase
CXD84_RS15320	COG0346	lactoylglutathione lyase activity
CXD84_RS15325	COG0513	Belongs to the DEAD box helicase family
CXD84_RS15330	COG3069	C4-dicarboxylate transmembrane transporter activity
CXD84_RS15350	COG1042	CoA-binding domain protein
CXD84_RS15350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CXD84_RS15350	COG0045	succinate-CoA ligase (ADP-forming) activity
CXD84_RS15355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CXD84_RS15370	COG1522	sequence-specific DNA binding
CXD84_RS15405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXD84_RS15410	COG1696	Membrane protein involved in D-alanine export
CXD84_RS15435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CXD84_RS15450	COG0439	Biotin carboxylase
CXD84_RS15455	COG0511	ligase activity, forming carbon-carbon bonds
CXD84_RS15460	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CXD84_RS15465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CXD84_RS15470	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CXD84_RS15475	COG3150	esterase
CXD84_RS15480	COG0557	exoribonuclease II activity
CXD84_RS15490	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CXD84_RS15515	COG1522	sequence-specific DNA binding
CXD84_RS15520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD84_RS15525	COG1028	Short-chain dehydrogenase reductase Sdr
CXD84_RS15545	COG0653	protein targeting
CXD84_RS15550	COG0739	heme binding
CXD84_RS15560	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CXD84_RS15565	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CXD84_RS15575	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CXD84_RS15580	COG1181	Belongs to the D-alanine--D-alanine ligase family
CXD84_RS15585	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CXD84_RS15590	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CXD84_RS15600	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CXD84_RS15605	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CXD84_RS15610	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CXD84_RS15620	COG3116	cell division
CXD84_RS15625	COG0275	rRNA processing
CXD84_RS15630	COG2001	Belongs to the MraZ family
CXD84_RS15640	COG0488	(ABC) transporter
CXD84_RS15645	COG0418	dihydroorotase activity
CXD84_RS15650	COG1473	amidohydrolase
CXD84_RS15700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CXD84_RS15705	COG4654	Cytochrome c, class I
CXD84_RS15710	COG0129	dihydroxy-acid dehydratase activity
CXD84_RS15715	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CXD84_RS15770	COG2084	Dehydrogenase
CXD84_RS15785	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CXD84_RS15790	COG0513	Belongs to the DEAD box helicase family
CXD84_RS15800	COG0617	tRNA 3'-terminal CCA addition
CXD84_RS15815	COG0477	Major facilitator Superfamily
CXD84_RS15825	COG0583	DNA-binding transcription factor activity
CXD84_RS15840	COG1950	PFAM Membrane protein of
CXD84_RS15845	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CXD84_RS15860	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CXD84_RS15870	COG1560	Kdo2-lipid A biosynthetic process
CXD84_RS15875	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CXD84_RS15885	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CXD84_RS15895	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CXD84_RS15905	COG0803	Belongs to the bacterial solute-binding protein 9 family
CXD84_RS15920	COG0735	belongs to the Fur family
CXD84_RS15925	COG0523	cobalamin synthesis protein
CXD84_RS15935	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CXD84_RS15940	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CXD84_RS15955	COG2096	Adenosyltransferase
CXD84_RS15965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXD84_RS15970	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CXD84_RS16045	COG0405	Gamma-glutamyltransferase
CXD84_RS16055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD84_RS16085	COG1309	transcriptional regulator
CXD84_RS16100	COG0745	RESPONSE REGULATOR receiver
CXD84_RS16150	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CXD84_RS16175	COG0582	viral genome integration into host DNA
CXD84_RS16180	COG0012	GTP binding
CXD84_RS16190	COG0193	aminoacyl-tRNA hydrolase activity
CXD84_RS16195	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CXD84_RS16200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CXD84_RS16210	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CXD84_RS16215	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CXD84_RS16225	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CXD84_RS16250	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CXD84_RS16260	COG1368	sulfuric ester hydrolase activity
CXD84_RS16265	COG0642	Histidine kinase
CXD84_RS16270	COG0745	RESPONSE REGULATOR receiver
CXD84_RS16275	COG0277	FAD linked oxidase domain protein
CXD84_RS16290	COG0166	Belongs to the GPI family
CXD84_RS16295	COG0438	transferase activity, transferring glycosyl groups
CXD84_RS16300	COG0438	transferase activity, transferring glycosyl groups
CXD84_RS16315	COG0438	transferase activity, transferring glycosyl groups
CXD84_RS16330	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CXD84_RS16335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CXD84_RS16340	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CXD84_RS16350	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CXD84_RS16360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXD84_RS16365	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CXD84_RS16375	COG0747	negative chemotaxis
CXD84_RS16380	COG0601	transmembrane transport
CXD84_RS16385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD84_RS16405	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CXD84_RS16410	COG0830	nickel cation binding
CXD84_RS16420	COG0804	urea catabolic process
CXD84_RS16425	COG0832	Belongs to the urease beta subunit family
CXD84_RS16435	COG0831	urea catabolic process
CXD84_RS16440	COG0829	nickel cation binding
CXD84_RS16470	COG2188	Transcriptional regulator
CXD84_RS16495	COG2719	SpoVR family
CXD84_RS16500	COG2718	Belongs to the UPF0229 family
CXD84_RS16525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD84_RS16540	COG1960	acyl-CoA dehydrogenase activity
CXD84_RS16590	COG2030	dehydratase
CXD84_RS16640	COG0328	RNA-DNA hybrid ribonuclease activity
CXD84_RS16645	COG2226	methyltransferase
CXD84_RS16650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CXD84_RS16655	COG1388	LysM domain
CXD84_RS16655	COG0741	lytic transglycosylase activity
CXD84_RS16675	COG2979	Protein of unknown function (DUF533)
CXD84_RS16710	COG1271	oxidase subunit
CXD84_RS16715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CXD84_RS16720	COG0850	regulation of cytokinetic process
CXD84_RS16725	COG2894	cell division
CXD84_RS16730	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CXD84_RS16765	COG0601	transmembrane transport
CXD84_RS16775	COG1215	transferase activity, transferring glycosyl groups
CXD84_RS16790	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CXD84_RS16800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CXD84_RS16820	COG0318	PFAM AMP-dependent synthetase and ligase
CXD84_RS16825	COG2188	Transcriptional regulator
CXD84_RS16830	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CXD84_RS16835	COG2814	Major facilitator Superfamily
CXD84_RS16845	COG0259	pyridoxamine-phosphate oxidase activity
CXD84_RS16850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CXD84_RS16865	COG0583	DNA-binding transcription factor activity
CXD84_RS16890	COG0134	indole-3-glycerol-phosphate synthase activity
CXD84_RS16895	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CXD84_RS16900	COG0512	Glutamine amidotransferase of anthranilate synthase
CXD84_RS16910	COG0546	phosphoglycolate phosphatase activity
CXD84_RS16915	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CXD84_RS16920	COG2967	ApaG domain
CXD84_RS16925	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CXD84_RS16930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CXD84_RS16935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CXD84_RS16940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CXD84_RS16950	COG0037	tRNA processing
CXD84_RS16960	COG3634	alkyl hydroperoxide reductase activity
CXD84_RS16965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CXD84_RS16970	COG1024	Enoyl-CoA hydratase
CXD84_RS16995	COG0356	it plays a direct role in the translocation of protons across the membrane
CXD84_RS17005	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CXD84_RS17010	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CXD84_RS17015	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CXD84_RS17020	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CXD84_RS17025	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CXD84_RS17030	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CXD84_RS17040	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CXD84_RS17045	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CXD84_RS17050	COG0210	DNA helicase
CXD84_RS17060	COG2195	Cleaves the N-terminal amino acid of tripeptides
CXD84_RS17070	COG4172	Belongs to the ABC transporter superfamily
CXD84_RS17075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD84_RS17080	COG0601	transmembrane transport
CXD84_RS17100	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CXD84_RS17105	COG1024	Enoyl-CoA hydratase
CXD84_RS17110	COG1024	Enoyl-CoA hydratase
CXD84_RS17160	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CXD84_RS17175	COG1137	ATPase activity
CXD84_RS17190	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CXD84_RS17200	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CXD84_RS17235	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CXD84_RS17240	COG3568	Endonuclease Exonuclease Phosphatase
CXD84_RS17245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXD84_RS17275	COG0154	amidase activity
CXD84_RS17285	COG1414	Transcriptional regulator
CXD84_RS17295	COG1024	Enoyl-CoA hydratase
CXD84_RS17295	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXD84_RS17330	COG1660	Displays ATPase and GTPase activities
CXD84_RS17335	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CXD84_RS17370	COG3181	Tripartite tricarboxylate transporter family receptor
CXD84_RS17380	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CXD84_RS17385	COG2890	protein-(glutamine-N5) methyltransferase activity
CXD84_RS17390	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CXD84_RS17395	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CXD84_RS17435	COG1960	acyl-CoA dehydrogenase activity
CXD84_RS17445	COG0183	Belongs to the thiolase family
CXD84_RS17450	COG1522	sequence-specific DNA binding
CXD84_RS17455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CXD84_RS17475	COG1024	Enoyl-CoA hydratase
CXD84_RS17490	COG0604	alcohol dehydrogenase
CXD84_RS17495	COG2072	flavoprotein involved in K transport
CXD84_RS17510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CXD84_RS17520	COG1960	acyl-CoA dehydrogenase activity
CXD84_RS17525	COG1960	acyl-CoA dehydrogenase activity
CXD84_RS17530	COG0277	FAD linked oxidase domain protein
CXD84_RS17540	COG3181	Tripartite tricarboxylate transporter family receptor
CXD84_RS17570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXD84_RS17580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD84_RS17585	COG3181	Tripartite tricarboxylate transporter family receptor
CXD84_RS17590	COG1960	acyl-CoA dehydrogenase activity
CXD84_RS17610	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CXD84_RS17615	COG1024	Enoyl-CoA hydratase
CXD84_RS17620	COG1960	acyl-CoA dehydrogenase activity
CXD84_RS17640	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CXD84_RS17645	COG0022	dehydrogenase e1 component
CXD84_RS17650	COG1024	Enoyl-CoA hydratase
CXD84_RS17655	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXD84_RS17675	COG0683	leucine binding
CXD84_RS17680	COG0559	Belongs to the binding-protein-dependent transport system permease family
CXD84_RS17685	COG0411	ABC transporter
CXD84_RS17695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CXD84_RS17710	COG3181	Tripartite tricarboxylate transporter family receptor
CXD84_RS17740	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CXD84_RS17745	COG0793	Belongs to the peptidase S41A family
CXD84_RS17750	COG4942	peptidase
CXD84_RS17755	COG0588	phosphoglycerate mutase activity
CXD84_RS17760	COG1054	Belongs to the UPF0176 family
CXD84_RS17765	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CXD84_RS17770	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CXD84_RS17775	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CXD84_RS17780	COG3181	Tripartite tricarboxylate transporter family receptor
CXD84_RS17795	COG2226	methyltransferase
CXD84_RS17800	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CXD84_RS17815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD84_RS17820	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CXD84_RS17845	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CXD84_RS17870	COG1335	isochorismatase
CXD84_RS17875	COG2309	aminopeptidase activity
CXD84_RS17895	COG2068	MobA-Related Protein
CXD84_RS17920	COG2204	response regulator
CXD84_RS17925	COG5000	phosphorelay sensor kinase activity
CXD84_RS17935	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CXD84_RS17935	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CXD84_RS17945	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CXD84_RS17970	COG0583	DNA-binding transcription factor activity
CXD84_RS17990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXD84_RS17995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD84_RS18010	COG0758	DNA mediated transformation
CXD84_RS18015	COG1522	sequence-specific DNA binding
CXD84_RS18025	COG0242	peptide deformylase activity
CXD84_RS18040	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CXD84_RS18050	COG0546	phosphoglycolate phosphatase activity
CXD84_RS18070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CXD84_RS18075	COG1942	4-Oxalocrotonate Tautomerase
CXD84_RS18080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXD84_RS18105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CXD84_RS18125	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CXD84_RS18130	COG1024	Enoyl-CoA hydratase
CXD84_RS18135	COG1414	Transcriptional regulator
CXD84_RS18140	COG0318	PFAM AMP-dependent synthetase and ligase
CXD84_RS18145	COG3181	Tripartite tricarboxylate transporter family receptor
CXD84_RS18190	COG3422	double-strand break repair
CXD84_RS18195	COG0330	HflC and HflK could
CXD84_RS18205	COG0251	oxidation-reduction process
CXD84_RS18255	COG3723	Recombinational DNA repair protein, rece pathway
CXD84_RS18290	COG0582	viral genome integration into host DNA
CXD84_RS18335	COG0706	membrane insertase activity
CXD84_RS18340	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CXD84_RS18345	COG0594	ribonuclease P activity
CXD84_RS18350	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CXD84_RS18355	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CXD84_RS18370	COG1414	Transcriptional regulator
CXD84_RS18375	COG0154	amidase activity
CXD84_RS18390	COG1304	FMN binding
CXD84_RS18440	COG0183	Belongs to the thiolase family
CXD84_RS18445	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CXD84_RS18460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CXD84_RS18465	COG3181	Tripartite tricarboxylate transporter family receptor
CXD84_RS18475	COG2358	TRAP transporter, solute receptor (TAXI family
CXD84_RS18485	COG1629	transport
CXD84_RS18490	COG2922	Belongs to the Smg family
CXD84_RS18515	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CXD84_RS18520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD84_RS18525	COG1028	Short-chain dehydrogenase reductase Sdr
CXD84_RS18530	COG1012	belongs to the aldehyde dehydrogenase family
CXD84_RS18540	COG0028	Belongs to the TPP enzyme family
CXD84_RS18545	COG1522	sequence-specific DNA binding
CXD84_RS18550	COG3781	membrane
CXD84_RS18560	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CXD84_RS18580	COG4206	TonB-dependent receptor
CXD84_RS18585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CXD84_RS18590	COG2022	thiamine diphosphate biosynthetic process
CXD84_RS18595	COG0351	phosphomethylpyrimidine kinase
CXD84_RS18600	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CXD84_RS18615	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CXD84_RS18625	COG0628	permease
CXD84_RS18635	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CXD84_RS18650	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CXD84_RS18655	COG0049	tRNA binding
CXD84_RS18660	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CXD84_RS18665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CXD84_RS18670	COG0051	transcription antitermination factor activity, RNA binding
CXD84_RS18675	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CXD84_RS18680	COG0088	Forms part of the polypeptide exit tunnel
CXD84_RS18685	COG0089	rRNA binding
CXD84_RS18690	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CXD84_RS18695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CXD84_RS18700	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CXD84_RS18705	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CXD84_RS18710	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CXD84_RS18715	COG0255	Belongs to the universal ribosomal protein uL29 family
CXD84_RS18720	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CXD84_RS18740	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CXD84_RS18745	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CXD84_RS18750	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CXD84_RS18755	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CXD84_RS18760	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CXD84_RS18765	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CXD84_RS18770	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CXD84_RS18775	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CXD84_RS18780	COG1841	ribosomal large subunit assembly
CXD84_RS18785	COG0200	Binds to the 23S rRNA
CXD84_RS18790	COG0201	protein transport
CXD84_RS18795	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CXD84_RS18800	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CXD84_RS18805	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CXD84_RS18810	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CXD84_RS18815	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CXD84_RS18820	COG0202	RNA polymerase activity
CXD84_RS18825	COG0203	ribosomal protein L17
CXD84_RS18830	COG0537	adenosine 5'-monophosphoramidase activity
CXD84_RS18835	COG1324	tolerance protein
CXD84_RS18840	COG4232	protein-disulfide reductase activity
CXD84_RS18855	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CXD84_RS18865	COG1333	cytochrome c biogenesis protein
CXD84_RS18870	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CXD84_RS18885	COG1965	Belongs to the frataxin family
CXD84_RS18895	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CXD84_RS18900	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CXD84_RS18905	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CXD84_RS18920	COG2814	Major facilitator Superfamily
CXD84_RS18925	COG0629	single-stranded DNA binding
CXD84_RS18965	COG0402	S-adenosylhomocysteine deaminase activity
CXD84_RS18975	COG0438	transferase activity, transferring glycosyl groups
CXD84_RS18995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD84_RS19020	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CXD84_RS19045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXD84_RS19050	COG1956	GAF domain-containing protein
CXD84_RS19055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXD84_RS19070	COG1652	LysM domain
CXD84_RS19085	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CXD84_RS19100	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CXD84_RS19130	COG3181	Tripartite tricarboxylate transporter family receptor
CXD84_RS19145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD84_RS19160	COG1024	Enoyl-CoA hydratase
CXD84_RS19175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD84_RS19180	COG1309	transcriptional regulator
CXD84_RS19185	COG2816	NAD+ diphosphatase activity
CXD84_RS19190	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CXD84_RS19275	COG2814	Major facilitator Superfamily
CXD84_RS19280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CXD84_RS19300	COG1999	signal sequence binding
CXD84_RS19305	COG0109	protoheme IX farnesyltransferase activity
CXD84_RS19345	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CXD84_RS19365	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CXD84_RS19370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CXD84_RS19380	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CXD84_RS19385	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CXD84_RS19395	COG0069	glutamate synthase activity
CXD84_RS19395	COG0067	glutamate synthase
CXD84_RS19395	COG0070	glutamate synthase
CXD84_RS19405	COG3047	cAMP biosynthetic process
CXD84_RS19415	COG1127	ABC transporter
CXD84_RS19420	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CXD84_RS19425	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CXD84_RS19430	COG2853	Lipoprotein
CXD84_RS19465	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CXD84_RS19470	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CXD84_RS19475	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CXD84_RS19480	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CXD84_RS19485	COG0131	Imidazoleglycerol-phosphate dehydratase
CXD84_RS19490	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CXD84_RS19495	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CXD84_RS19500	COG0107	imidazoleglycerol-phosphate synthase activity
CXD84_RS19505	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CXD84_RS19510	COG0140	phosphoribosyl-ATP diphosphatase activity
CXD84_RS19515	COG0537	adenosine 5'-monophosphoramidase activity
CXD84_RS19520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CXD84_RS19525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CXD84_RS19575	COG3702	type iv secretory pathway
CXD84_RS19580	COG3451	type IV secretory pathway VirB4
CXD84_RS19595	COG3736	Type IV secretory pathway, component VirB8
CXD84_RS19600	COG3504	Conjugal transfer protein
CXD84_RS19605	COG2948	multi-organism process
CXD84_RS19610	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
CXD84_RS19620	COG0697	spore germination
CXD84_RS19640	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CXD84_RS19645	COG0747	negative chemotaxis
CXD84_RS19650	COG0601	transmembrane transport
CXD84_RS19655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXD84_RS19670	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CXD84_RS19680	COG0494	nUDIX hydrolase
CXD84_RS19715	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CXD84_RS19720	COG0237	dephospho-CoA kinase activity
CXD84_RS19725	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CXD84_RS19740	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CXD84_RS19745	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CXD84_RS19755	COG0477	Major facilitator Superfamily
CXD84_RS19760	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CXD84_RS19775	COG1126	abc transporter atp-binding protein
CXD84_RS19780	COG0765	amino acid transport
CXD84_RS19785	COG4597	amino acid ABC transporter
CXD84_RS19790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXD84_RS19795	COG2884	Cell division ATP-binding protein ftsE
CXD84_RS19800	COG2177	Part of the ABC transporter FtsEX involved in
CXD84_RS19805	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CXD84_RS19815	COG1194	a g-specific adenine glycosylase
CXD84_RS19825	COG2226	methyltransferase
CXD84_RS19840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD84_RS19845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD84_RS19860	COG1024	Enoyl-CoA hydratase
CXD84_RS19880	COG1024	Enoyl-CoA hydratase
CXD84_RS19885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXD84_RS19900	COG0753	catalase activity
CXD84_RS19905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXD84_RS19910	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CXD84_RS19920	COG2175	clavaminate synthase activity
CXD84_RS19925	COG1473	amidohydrolase
CXD84_RS19930	COG4608	Belongs to the ABC transporter superfamily
CXD84_RS19935	COG0444	Belongs to the ABC transporter superfamily
CXD84_RS19950	COG0747	negative chemotaxis
CXD84_RS19955	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CXD84_RS19990	COG0436	Aminotransferase
CXD84_RS19995	COG1278	Cold shock