locus-tag	class	description
I6K95_RS00010	COG3128	pkhd-type hydroxylase
I6K95_RS00015	COG0776	regulation of translation
I6K95_RS00045	COG0642	Histidine kinase
I6K95_RS00050	COG3158	transport of potassium into the cell
I6K95_RS00055	COG0137	argininosuccinate synthase activity
I6K95_RS00060	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6K95_RS00065	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K95_RS00075	COG0583	DNA-binding transcription factor activity
I6K95_RS00085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6K95_RS00105	COG2186	Transcriptional regulator
I6K95_RS00115	COG2223	nitrite transmembrane transporter activity
I6K95_RS00125	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K95_RS00130	COG0450	alkyl hydroperoxide reductase
I6K95_RS00150	COG1214	PFAM Peptidase M22, glycoprotease
I6K95_RS00155	COG1573	uracil-dna glycosylase
I6K95_RS00160	COG0477	Major facilitator Superfamily
I6K95_RS00165	COG1196	nuclear chromosome segregation
I6K95_RS00175	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6K95_RS00180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K95_RS00195	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6K95_RS00200	COG1122	ATPase activity
I6K95_RS00205	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6K95_RS00210	COG1268	BioY protein
I6K95_RS00230	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6K95_RS00265	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6K95_RS00270	COG2878	Part of a membrane complex involved in electron transport
I6K95_RS00285	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6K95_RS00290	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6K95_RS00295	COG0251	oxidation-reduction process
I6K95_RS00305	COG3228	Belongs to the MtfA family
I6K95_RS00310	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K95_RS00320	COG0133	tryptophan synthase activity
I6K95_RS00325	COG0159	tryptophan synthase activity
I6K95_RS00330	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6K95_RS00350	COG4206	TonB-dependent receptor
I6K95_RS00355	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K95_RS00360	COG2022	thiamine diphosphate biosynthetic process
I6K95_RS00365	COG0351	phosphomethylpyrimidine kinase
I6K95_RS00370	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6K95_RS00385	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6K95_RS00395	COG0628	permease
I6K95_RS00405	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6K95_RS00415	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6K95_RS00420	COG0049	tRNA binding
I6K95_RS00425	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6K95_RS00430	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6K95_RS00435	COG0051	transcription antitermination factor activity, RNA binding
I6K95_RS00440	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6K95_RS00445	COG0088	Forms part of the polypeptide exit tunnel
I6K95_RS00450	COG0089	rRNA binding
I6K95_RS00455	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6K95_RS00460	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6K95_RS00465	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6K95_RS00470	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6K95_RS00475	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6K95_RS00480	COG0255	Belongs to the universal ribosomal protein uL29 family
I6K95_RS00485	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6K95_RS00505	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6K95_RS00510	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6K95_RS00515	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6K95_RS00520	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6K95_RS00525	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6K95_RS00530	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6K95_RS00535	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6K95_RS00540	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6K95_RS00545	COG1841	ribosomal large subunit assembly
I6K95_RS00550	COG0200	Binds to the 23S rRNA
I6K95_RS00555	COG0201	protein transport
I6K95_RS00560	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6K95_RS00565	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6K95_RS00570	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6K95_RS00575	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6K95_RS00580	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6K95_RS00585	COG0202	RNA polymerase activity
I6K95_RS00590	COG0203	ribosomal protein L17
I6K95_RS00595	COG0537	adenosine 5'-monophosphoramidase activity
I6K95_RS00600	COG1324	tolerance protein
I6K95_RS00605	COG4232	protein-disulfide reductase activity
I6K95_RS00620	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6K95_RS00630	COG1333	cytochrome c biogenesis protein
I6K95_RS00635	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K95_RS00645	COG1965	Belongs to the frataxin family
I6K95_RS00655	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6K95_RS00660	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6K95_RS00665	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6K95_RS00680	COG2814	Major facilitator Superfamily
I6K95_RS00685	COG0629	single-stranded DNA binding
I6K95_RS00725	COG0402	S-adenosylhomocysteine deaminase activity
I6K95_RS00735	COG0438	transferase activity, transferring glycosyl groups
I6K95_RS00755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K95_RS00775	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6K95_RS00800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K95_RS00805	COG1956	GAF domain-containing protein
I6K95_RS00810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K95_RS00820	COG1652	LysM domain
I6K95_RS00835	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6K95_RS00850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6K95_RS00880	COG3181	Tripartite tricarboxylate transporter family receptor
I6K95_RS00895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K95_RS00910	COG1024	Enoyl-CoA hydratase
I6K95_RS00925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K95_RS00930	COG1309	transcriptional regulator
I6K95_RS00935	COG2816	NAD+ diphosphatase activity
I6K95_RS00940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K95_RS01025	COG2814	Major facilitator Superfamily
I6K95_RS01030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6K95_RS01050	COG1999	signal sequence binding
I6K95_RS01055	COG0109	protoheme IX farnesyltransferase activity
I6K95_RS01090	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6K95_RS01110	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K95_RS01115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K95_RS01125	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6K95_RS01130	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6K95_RS01140	COG0070	glutamate synthase
I6K95_RS01140	COG0067	glutamate synthase
I6K95_RS01140	COG0069	glutamate synthase activity
I6K95_RS01150	COG3047	cAMP biosynthetic process
I6K95_RS01160	COG1127	ABC transporter
I6K95_RS01165	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6K95_RS01170	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K95_RS01175	COG2853	Lipoprotein
I6K95_RS01190	COG0842	Transport permease protein
I6K95_RS01200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6K95_RS01205	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6K95_RS01210	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6K95_RS01215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6K95_RS01220	COG0131	Imidazoleglycerol-phosphate dehydratase
I6K95_RS01225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6K95_RS01230	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6K95_RS01235	COG0107	imidazoleglycerol-phosphate synthase activity
I6K95_RS01240	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6K95_RS01245	COG0140	phosphoribosyl-ATP diphosphatase activity
I6K95_RS01250	COG0537	adenosine 5'-monophosphoramidase activity
I6K95_RS01255	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6K95_RS01260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6K95_RS01285	COG3181	Tripartite tricarboxylate transporter family receptor
I6K95_RS01320	COG3702	type iv secretory pathway
I6K95_RS01325	COG3451	type IV secretory pathway VirB4
I6K95_RS01340	COG3736	Type IV secretory pathway, component VirB8
I6K95_RS01345	COG3504	Conjugal transfer protein
I6K95_RS01350	COG2948	multi-organism process
I6K95_RS01355	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
I6K95_RS01365	COG0697	spore germination
I6K95_RS01385	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6K95_RS01390	COG0747	negative chemotaxis
I6K95_RS01395	COG0601	transmembrane transport
I6K95_RS01400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K95_RS01415	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6K95_RS01425	COG0494	nUDIX hydrolase
I6K95_RS01460	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I6K95_RS01465	COG0237	dephospho-CoA kinase activity
I6K95_RS01470	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6K95_RS01485	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6K95_RS01490	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6K95_RS01500	COG0477	Major facilitator Superfamily
I6K95_RS01505	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6K95_RS01520	COG1126	abc transporter atp-binding protein
I6K95_RS01525	COG0765	amino acid transport
I6K95_RS01530	COG4597	amino acid ABC transporter
I6K95_RS01535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K95_RS01540	COG2884	Cell division ATP-binding protein ftsE
I6K95_RS01545	COG2177	Part of the ABC transporter FtsEX involved in
I6K95_RS01550	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I6K95_RS01560	COG1194	a g-specific adenine glycosylase
I6K95_RS01570	COG2226	methyltransferase
I6K95_RS01580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K95_RS01585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K95_RS01600	COG1024	Enoyl-CoA hydratase
I6K95_RS01620	COG1024	Enoyl-CoA hydratase
I6K95_RS01625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K95_RS01640	COG0753	catalase activity
I6K95_RS01645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K95_RS01650	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6K95_RS01660	COG2175	clavaminate synthase activity
I6K95_RS01665	COG1473	amidohydrolase
I6K95_RS01670	COG4608	Belongs to the ABC transporter superfamily
I6K95_RS01675	COG0444	Belongs to the ABC transporter superfamily
I6K95_RS01690	COG0747	negative chemotaxis
I6K95_RS01695	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6K95_RS01730	COG0436	Aminotransferase
I6K95_RS01735	COG1278	Cold shock
I6K95_RS01740	COG0445	tRNA wobble uridine modification
I6K95_RS01745	COG0357	Ribosomal RNA small subunit methyltransferase G
I6K95_RS01750	COG1192	Involved in chromosome partitioning
I6K95_RS01760	COG1475	DNA binding
I6K95_RS01765	COG0252	asparaginase activity
I6K95_RS01790	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6K95_RS01800	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6K95_RS01810	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6K95_RS01815	COG0081	regulation of translation
I6K95_RS01820	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6K95_RS01825	COG0222	ribosome binding
I6K95_RS01830	COG0085	RNA polymerase activity
I6K95_RS01835	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6K95_RS01875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K95_RS01900	COG1024	Enoyl-CoA hydratase
I6K95_RS01920	COG0752	glycyl-tRNA synthetase alpha subunit
I6K95_RS01925	COG0751	glycine-tRNA ligase activity
I6K95_RS01930	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6K95_RS01935	COG0204	Acyl-transferase
I6K95_RS01950	COG0242	peptide deformylase activity
I6K95_RS01995	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6K95_RS02000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6K95_RS02000	COG2813	Specifically methylates the guanine in position
I6K95_RS02010	COG2223	nitrite transmembrane transporter activity
I6K95_RS02020	COG1794	racemase activity, acting on amino acids and derivatives
I6K95_RS02025	COG1126	abc transporter atp-binding protein
I6K95_RS02030	COG0765	amino acid transport
I6K95_RS02035	COG0765	amino acid transport
I6K95_RS02040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K95_RS02105	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6K95_RS02135	COG0326	Molecular chaperone. Has ATPase activity
I6K95_RS02140	COG0625	glutathione transferase activity
I6K95_RS02155	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K95_RS02160	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6K95_RS02190	COG0438	transferase activity, transferring glycosyl groups
I6K95_RS02195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6K95_RS02200	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6K95_RS02230	COG0859	PFAM glycosyl transferase family 9
I6K95_RS02245	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6K95_RS02255	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6K95_RS02260	COG1127	ABC transporter
I6K95_RS02280	COG1686	Belongs to the peptidase S11 family
I6K95_RS02290	COG2921	Belongs to the UPF0250 family
I6K95_RS02295	COG0321	lipoyl(octanoyl) transferase activity
I6K95_RS02300	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6K95_RS02335	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K95_RS02345	COG0018	arginyl-trna synthetase
I6K95_RS02365	COG0395	ABC-type sugar transport system, permease component
I6K95_RS02370	COG1175	transmembrane transport
I6K95_RS02375	COG1653	transport
I6K95_RS02380	COG3842	ATPase activity
I6K95_RS02385	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K95_RS02400	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6K95_RS02420	COG1609	Transcriptional regulator
I6K95_RS02430	COG0154	amidase activity
I6K95_RS02435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6K95_RS02445	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6K95_RS02455	COG0583	DNA-binding transcription factor activity
I6K95_RS02475	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K95_RS02490	COG1802	Transcriptional regulator
I6K95_RS02505	COG1024	Enoyl-CoA hydratase
I6K95_RS02515	COG3181	Tripartite tricarboxylate transporter family receptor
I6K95_RS02530	COG1984	allophanate hydrolase subunit 2
I6K95_RS02535	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6K95_RS02545	COG0583	DNA-binding transcription factor activity
I6K95_RS02550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K95_RS02560	COG5002	protein histidine kinase activity
I6K95_RS02570	COG5002	protein histidine kinase activity
I6K95_RS02575	COG0745	RESPONSE REGULATOR receiver
I6K95_RS02580	COG2226	methyltransferase
I6K95_RS02595	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6K95_RS02615	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6K95_RS02625	COG0513	Belongs to the DEAD box helicase family
I6K95_RS02630	COG1280	lysine exporter protein (LysE YggA)
I6K95_RS02635	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6K95_RS02670	COG1054	Belongs to the UPF0176 family
I6K95_RS02675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K95_RS02675	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K95_RS02685	COG0489	protein tyrosine kinase activity
I6K95_RS02700	COG0717	Belongs to the dCTP deaminase family
I6K95_RS02730	COG2081	HI0933 family
I6K95_RS02740	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6K95_RS02750	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6K95_RS02755	COG0509	glycine decarboxylation via glycine cleavage system
I6K95_RS02760	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6K95_RS02760	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6K95_RS02800	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K95_RS02805	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6K95_RS02810	COG1012	belongs to the aldehyde dehydrogenase family
I6K95_RS02835	COG4257	antibiotic catabolic process
I6K95_RS02845	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6K95_RS02850	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6K95_RS02860	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K95_RS02865	COG2031	fatty acid transporter
I6K95_RS02870	COG1028	Short-chain dehydrogenase reductase Sdr
I6K95_RS02875	COG1414	Transcriptional regulator
I6K95_RS02885	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K95_RS02900	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6K95_RS02920	COG1028	Short-chain dehydrogenase reductase Sdr
I6K95_RS02930	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K95_RS02940	COG2188	Transcriptional regulator
I6K95_RS02945	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6K95_RS02970	COG0617	tRNA 3'-terminal CCA addition
I6K95_RS02990	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6K95_RS02995	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6K95_RS03000	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6K95_RS03005	COG0586	Pfam SNARE associated Golgi protein
I6K95_RS03010	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K95_RS03015	COG0802	atpase or kinase
I6K95_RS03020	COG0114	fumarate hydratase activity
I6K95_RS03030	COG3181	Tripartite tricarboxylate transporter family receptor
I6K95_RS03040	COG0405	Gamma-glutamyltransferase
I6K95_RS03045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K95_RS03080	COG1294	oxidase, subunit
I6K95_RS03090	COG4988	ABC transporter
I6K95_RS03095	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6K95_RS03100	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6K95_RS03140	COG2969	positive regulation of protein catabolic process
I6K95_RS03145	COG0625	glutathione transferase activity
I6K95_RS03150	COG2857	Cytochrome c1
I6K95_RS03155	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6K95_RS03160	COG0723	plastoquinol--plastocyanin reductase activity
I6K95_RS03165	COG1970	mechanosensitive ion channel activity
I6K95_RS03170	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6K95_RS03185	COG2808	Putative FMN-binding domain
I6K95_RS03190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K95_RS03195	COG0747	negative chemotaxis
I6K95_RS03200	COG0657	acetylesterase activity
I6K95_RS03210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6K95_RS03215	COG2207	Transcriptional regulator
I6K95_RS03220	COG0129	dihydroxy-acid dehydratase activity
I6K95_RS03225	COG2814	Major facilitator Superfamily
I6K95_RS03230	COG0583	DNA-binding transcription factor activity
I6K95_RS03240	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
I6K95_RS03310	COG1024	Enoyl-CoA hydratase
I6K95_RS03315	COG1960	acyl-CoA dehydrogenase activity
I6K95_RS03340	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6K95_RS03345	COG0352	thiamine-phosphate diphosphorylase activity
I6K95_RS03360	COG1678	Uncharacterized ACR, COG1678
I6K95_RS03365	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6K95_RS03370	COG0540	Belongs to the ATCase OTCase family
I6K95_RS03385	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6K95_RS03395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K95_RS03430	COG1234	tRNA 3'-trailer cleavage
I6K95_RS03450	COG3064	Membrane
I6K95_RS03480	COG1683	Conserved Protein
I6K95_RS03485	COG1120	ATPase activity
I6K95_RS03490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K95_RS03495	COG4558	Periplasmic binding protein
I6K95_RS03500	COG3720	iron ion transport
I6K95_RS03510	COG3712	iron ion homeostasis
I6K95_RS03515	COG1595	DNA-templated transcription, initiation
I6K95_RS03550	COG1802	Transcriptional regulator
I6K95_RS03560	COG3069	C4-dicarboxylate transmembrane transporter activity
I6K95_RS03570	COG1012	belongs to the aldehyde dehydrogenase family
I6K95_RS03605	COG2860	membrane
I6K95_RS03610	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K95_RS03615	COG0708	Exodeoxyribonuclease III
I6K95_RS03620	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6K95_RS03625	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6K95_RS03630	COG0154	amidase activity
I6K95_RS03635	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6K95_RS03640	COG1077	Cell shape determining protein MreB Mrl
I6K95_RS03645	COG1792	Involved in formation and maintenance of cell shape
I6K95_RS03655	COG0768	penicillin binding
I6K95_RS03660	COG0772	Belongs to the SEDS family
I6K95_RS03665	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6K95_RS03670	COG0471	metal ion transport
I6K95_RS03675	COG1309	transcriptional regulator
I6K95_RS03685	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6K95_RS03700	COG2823	Periplasmic or secreted lipoprotein
I6K95_RS03705	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6K95_RS03720	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K95_RS03730	COG0697	spore germination
I6K95_RS03760	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6K95_RS03765	COG0463	Glycosyl transferase, family 2
I6K95_RS03780	COG0786	glutamate:sodium symporter activity
I6K95_RS03790	COG2031	fatty acid transporter
I6K95_RS03805	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K95_RS03820	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6K95_RS03835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K95_RS03845	COG1285	pathogenesis
I6K95_RS03850	COG1253	flavin adenine dinucleotide binding
I6K95_RS03855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K95_RS03860	COG1024	Enoyl-CoA hydratase
I6K95_RS03865	COG3181	Tripartite tricarboxylate transporter family receptor
I6K95_RS03870	COG0583	DNA-binding transcription factor activity
I6K95_RS03875	COG1960	acyl-CoA dehydrogenase activity
I6K95_RS03885	COG0183	Belongs to the thiolase family
I6K95_RS03900	COG0583	DNA-binding transcription factor activity
I6K95_RS03905	COG1278	Cold shock
I6K95_RS03915	COG1802	Transcriptional regulator
I6K95_RS03920	COG1012	belongs to the aldehyde dehydrogenase family
I6K95_RS03925	COG2031	fatty acid transporter
I6K95_RS03935	COG0251	oxidation-reduction process
I6K95_RS03955	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K95_RS03965	COG0583	DNA-binding transcription factor activity
I6K95_RS03970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K95_RS04015	COG0183	Belongs to the thiolase family
I6K95_RS04020	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6K95_RS04035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K95_RS04040	COG3181	Tripartite tricarboxylate transporter family receptor
I6K95_RS04050	COG2358	TRAP transporter, solute receptor (TAXI family
I6K95_RS04060	COG1629	transport
I6K95_RS04065	COG2922	Belongs to the Smg family
I6K95_RS04090	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6K95_RS04095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K95_RS04100	COG1028	Short-chain dehydrogenase reductase Sdr
I6K95_RS04105	COG1012	belongs to the aldehyde dehydrogenase family
I6K95_RS04115	COG0028	Belongs to the TPP enzyme family
I6K95_RS04120	COG1522	sequence-specific DNA binding
I6K95_RS04125	COG3781	membrane
I6K95_RS04135	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6K95_RS04155	COG1530	ribonuclease E activity
I6K95_RS04165	COG0546	phosphoglycolate phosphatase activity
I6K95_RS04170	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6K95_RS04175	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6K95_RS04195	COG1304	FMN binding
I6K95_RS04210	COG0154	amidase activity
I6K95_RS04215	COG1414	Transcriptional regulator
I6K95_RS04230	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6K95_RS04235	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6K95_RS04240	COG0594	ribonuclease P activity
I6K95_RS04245	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6K95_RS04250	COG0706	membrane insertase activity
I6K95_RS04285	COG0582	viral genome integration into host DNA
I6K95_RS04315	COG3723	Recombinational DNA repair protein, rece pathway
I6K95_RS04360	COG0251	oxidation-reduction process
I6K95_RS04370	COG0330	HflC and HflK could
I6K95_RS04375	COG3422	double-strand break repair
I6K95_RS04415	COG3181	Tripartite tricarboxylate transporter family receptor
I6K95_RS04420	COG0318	PFAM AMP-dependent synthetase and ligase
I6K95_RS04425	COG1414	Transcriptional regulator
I6K95_RS04430	COG1024	Enoyl-CoA hydratase
I6K95_RS04435	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K95_RS04455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K95_RS04475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K95_RS04480	COG1942	4-Oxalocrotonate Tautomerase
I6K95_RS04485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6K95_RS04505	COG0546	phosphoglycolate phosphatase activity
I6K95_RS04515	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6K95_RS04520	COG0242	peptide deformylase activity
I6K95_RS04530	COG1522	sequence-specific DNA binding
I6K95_RS04535	COG0758	DNA mediated transformation
I6K95_RS04550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K95_RS04555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K95_RS04575	COG0583	DNA-binding transcription factor activity
I6K95_RS04595	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
I6K95_RS04605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6K95_RS04605	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6K95_RS04615	COG5000	phosphorelay sensor kinase activity
I6K95_RS04620	COG2204	response regulator
I6K95_RS04645	COG2068	MobA-Related Protein
I6K95_RS04655	COG3473	Maleate cis-trans isomerase
I6K95_RS04665	COG2309	aminopeptidase activity
I6K95_RS04670	COG1335	isochorismatase
I6K95_RS04695	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6K95_RS04720	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6K95_RS04725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K95_RS04740	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6K95_RS04745	COG2226	methyltransferase
I6K95_RS04760	COG3181	Tripartite tricarboxylate transporter family receptor
I6K95_RS04765	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6K95_RS04770	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6K95_RS04775	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K95_RS04780	COG1054	Belongs to the UPF0176 family
I6K95_RS04785	COG0588	phosphoglycerate mutase activity
I6K95_RS04790	COG4942	peptidase
I6K95_RS04795	COG0793	Belongs to the peptidase S41A family
I6K95_RS04800	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K95_RS04825	COG3181	Tripartite tricarboxylate transporter family receptor
I6K95_RS04840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K95_RS04850	COG0411	ABC transporter
I6K95_RS04855	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6K95_RS04860	COG0683	leucine binding
I6K95_RS04880	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K95_RS04885	COG1024	Enoyl-CoA hydratase
I6K95_RS04890	COG0022	dehydrogenase e1 component
I6K95_RS04895	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6K95_RS04915	COG1960	acyl-CoA dehydrogenase activity
I6K95_RS04920	COG1024	Enoyl-CoA hydratase
I6K95_RS04925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6K95_RS04945	COG1960	acyl-CoA dehydrogenase activity
I6K95_RS04950	COG3181	Tripartite tricarboxylate transporter family receptor
I6K95_RS04955	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K95_RS04965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K95_RS04995	COG3181	Tripartite tricarboxylate transporter family receptor
I6K95_RS05005	COG0277	FAD linked oxidase domain protein
I6K95_RS05010	COG1960	acyl-CoA dehydrogenase activity
I6K95_RS05015	COG1960	acyl-CoA dehydrogenase activity
I6K95_RS05025	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K95_RS05040	COG2072	flavoprotein involved in K transport
I6K95_RS05045	COG0604	alcohol dehydrogenase
I6K95_RS05060	COG1024	Enoyl-CoA hydratase
I6K95_RS05080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6K95_RS05085	COG1522	sequence-specific DNA binding
I6K95_RS05090	COG0183	Belongs to the thiolase family
I6K95_RS05100	COG1960	acyl-CoA dehydrogenase activity
I6K95_RS05145	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6K95_RS05150	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6K95_RS05155	COG2890	protein-(glutamine-N5) methyltransferase activity
I6K95_RS05160	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6K95_RS05170	COG3181	Tripartite tricarboxylate transporter family receptor
I6K95_RS05205	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K95_RS05210	COG1660	Displays ATPase and GTPase activities
I6K95_RS05220	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6K95_RS05220	COG2010	Cytochrome c
I6K95_RS05225	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I6K95_RS05240	COG1137	ATPase activity
I6K95_RS05255	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6K95_RS05265	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6K95_RS05300	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6K95_RS05305	COG3568	Endonuclease Exonuclease Phosphatase
I6K95_RS05310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K95_RS05345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K95_RS05350	COG0154	amidase activity
I6K95_RS05360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K95_RS05365	COG0601	transmembrane transport
I6K95_RS05370	COG0747	negative chemotaxis
I6K95_RS05390	COG0019	diaminopimelate decarboxylase activity
I6K95_RS05405	COG2353	YceI-like domain
I6K95_RS05410	COG4774	siderophore transport
I6K95_RS05415	COG3712	iron ion homeostasis
I6K95_RS05455	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6K95_RS05460	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6K95_RS05465	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6K95_RS05470	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6K95_RS05480	COG0142	geranyltranstransferase activity
I6K95_RS05490	COG0583	DNA-binding transcription factor activity
I6K95_RS05500	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
I6K95_RS05505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K95_RS05530	COG2994	toxin metabolic process
I6K95_RS05540	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I6K95_RS05545	COG2274	protein secretion by the type I secretion system
I6K95_RS05550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K95_RS05555	COG1538	Outer membrane efflux protein
I6K95_RS05575	COG0765	amino acid transport
I6K95_RS05580	COG1126	abc transporter atp-binding protein
I6K95_RS05600	COG1028	Short-chain dehydrogenase reductase Sdr
I6K95_RS05610	COG1802	Transcriptional regulator
I6K95_RS05620	COG1802	Transcriptional regulator
I6K95_RS05630	COG0318	PFAM AMP-dependent synthetase and ligase
I6K95_RS05640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K95_RS05660	COG0028	Belongs to the TPP enzyme family
I6K95_RS05680	COG0028	Belongs to the TPP enzyme family
I6K95_RS05685	COG0440	acetolactate synthase activity
I6K95_RS05690	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6K95_RS05695	COG1183	phosphatidylcholine synthase activity
I6K95_RS05705	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6K95_RS05710	COG1185	polyribonucleotide nucleotidyltransferase activity
I6K95_RS05725	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K95_RS05745	COG0149	triose-phosphate isomerase activity
I6K95_RS05750	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6K95_RS05760	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K95_RS05770	COG3799	methylaspartate ammonia-lyase activity
I6K95_RS05805	COG0583	DNA-binding transcription factor activity
I6K95_RS05810	COG0626	cystathionine gamma-synthase activity
I6K95_RS05815	COG3608	succinylglutamate desuccinylase aspartoacylase
I6K95_RS05835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K95_RS05855	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
I6K95_RS05870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K95_RS05875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K95_RS05880	COG1733	regulation of RNA biosynthetic process
I6K95_RS05890	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K95_RS05895	COG0583	DNA-binding transcription factor activity
I6K95_RS05910	COG0671	phosphoesterase, PA-phosphatase related
I6K95_RS05935	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K95_RS05940	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K95_RS05945	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K95_RS05950	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K95_RS05955	COG0649	NAD binding
I6K95_RS05960	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
I6K95_RS05970	COG1034	ATP synthesis coupled electron transport
I6K95_RS05975	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6K95_RS05980	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K95_RS05990	COG0713	ATP synthesis coupled electron transport
I6K95_RS06005	COG1007	ATP synthesis coupled electron transport
I6K95_RS06015	COG4774	siderophore transport
I6K95_RS06020	COG4774	siderophore transport
I6K95_RS06035	COG0028	Belongs to the TPP enzyme family
I6K95_RS06040	COG3181	Tripartite tricarboxylate transporter family receptor
I6K95_RS06045	COG0583	DNA-binding transcription factor activity
I6K95_RS06050	COG0560	Phosphoserine phosphatase
I6K95_RS06055	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6K95_RS06060	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6K95_RS06065	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6K95_RS06075	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6K95_RS06080	COG0308	aminopeptidase N
I6K95_RS06095	COG5265	(ABC) transporter
I6K95_RS06100	COG0500	methyltransferase
I6K95_RS06120	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I6K95_RS06150	COG0511	ligase activity, forming carbon-carbon bonds
I6K95_RS06175	COG2188	Transcriptional regulator
I6K95_RS06180	COG0439	Biotin carboxylase
I6K95_RS06225	COG5265	(ABC) transporter
I6K95_RS06235	COG0667	Aldo Keto reductase
I6K95_RS06250	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6K95_RS06300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K95_RS06310	COG2079	MmgE PrpD family protein
I6K95_RS06315	COG1012	belongs to the aldehyde dehydrogenase family
I6K95_RS06320	COG1053	succinate dehydrogenase
I6K95_RS06345	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K95_RS06360	COG0583	DNA-binding transcription factor activity
I6K95_RS06400	COG0583	DNA-binding transcription factor activity
I6K95_RS06425	COG2814	Major facilitator Superfamily
I6K95_RS06435	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6K95_RS06450	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6K95_RS06460	COG0287	Prephenate dehydrogenase
I6K95_RS06465	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6K95_RS06470	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6K95_RS06490	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6K95_RS06495	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6K95_RS06500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K95_RS06505	COG1596	polysaccharide export
I6K95_RS06505	COG1555	photosystem II stabilization
I6K95_RS06520	COG2951	lytic endotransglycosylase activity
I6K95_RS06525	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6K95_RS06540	COG1960	acyl-CoA dehydrogenase activity
I6K95_RS06545	COG0450	alkyl hydroperoxide reductase
I6K95_RS06565	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6K95_RS06600	COG0335	large ribosomal subunit rRNA binding
I6K95_RS06610	COG0667	Aldo Keto reductase
I6K95_RS06625	COG3161	chorismate lyase activity
I6K95_RS06630	COG1187	pseudouridine synthase activity
I6K95_RS06660	COG1999	signal sequence binding
I6K95_RS06665	COG0339	signal peptide processing
I6K95_RS06670	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6K95_RS06675	COG4566	intracellular signal transduction
I6K95_RS06685	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6K95_RS06690	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K95_RS06695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K95_RS06700	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6K95_RS06710	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6K95_RS06715	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K95_RS06720	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6K95_RS06725	COG0126	phosphoglycerate kinase activity
I6K95_RS06730	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6K95_RS06735	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6K95_RS06750	COG0625	glutathione transferase activity
I6K95_RS06790	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6K95_RS06795	COG0306	phosphate transporter
I6K95_RS06800	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K95_RS06810	COG0739	heme binding
I6K95_RS06820	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6K95_RS06855	COG0745	RESPONSE REGULATOR receiver
I6K95_RS06870	COG0840	transmembrane signaling receptor activity
I6K95_RS06880	COG2201	protein-glutamate methylesterase activity
I6K95_RS06885	COG0745	RESPONSE REGULATOR receiver
I6K95_RS06890	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6K95_RS06915	COG0667	Aldo Keto reductase
I6K95_RS06925	COG4535	Mg2 and Co2 transporter CorC
I6K95_RS06930	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6K95_RS06935	COG1702	phosphate starvation-inducible protein PhoH
I6K95_RS06940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6K95_RS06955	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K95_RS06960	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K95_RS06965	COG1862	Preprotein translocase
I6K95_RS06975	COG0343	queuine tRNA-ribosyltransferase activity
I6K95_RS06980	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6K95_RS06985	COG2027	D-alanyl-D-alanine carboxypeptidase
I6K95_RS06990	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6K95_RS07000	COG3468	outer membrane autotransporter barrel domain protein
I6K95_RS07005	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6K95_RS07005	COG1648	precorrin-2 dehydrogenase activity
I6K95_RS07030	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K95_RS07035	COG0741	lytic transglycosylase activity
I6K95_RS07040	COG0436	Aminotransferase
I6K95_RS07060	COG2732	(Barnase) inhibitor
I6K95_RS07075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6K95_RS07100	COG0248	Ppx GppA phosphatase
I6K95_RS07110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6K95_RS07120	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6K95_RS07130	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6K95_RS07135	COG1534	Rna-binding protein
I6K95_RS07165	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K95_RS07180	COG1295	ribonuclease BN
I6K95_RS07190	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6K95_RS07195	COG0745	RESPONSE REGULATOR receiver
I6K95_RS07200	COG2205	protein histidine kinase activity
I6K95_RS07235	COG1022	Amp-dependent synthetase and ligase
I6K95_RS07250	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6K95_RS07255	COG1028	Short-chain dehydrogenase reductase Sdr
I6K95_RS07265	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6K95_RS07280	COG1136	(ABC) transporter
I6K95_RS07285	COG0084	hydrolase, TatD family'
I6K95_RS07310	COG0658	competence protein
I6K95_RS07310	COG2333	competence protein COMEC
I6K95_RS07320	COG0613	PHP domain protein
I6K95_RS07335	COG3539	Fimbrial protein
I6K95_RS07340	COG0281	malic enzyme
I6K95_RS07340	COG0280	phosphate acetyltransferase
I6K95_RS07350	COG1522	sequence-specific DNA binding
I6K95_RS07355	COG1297	OPT oligopeptide transporter protein
I6K95_RS07360	COG0567	Dehydrogenase, E1 component
I6K95_RS07365	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K95_RS07370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K95_RS07375	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6K95_RS07380	COG1028	Short-chain dehydrogenase reductase Sdr
I6K95_RS07385	COG0583	DNA-binding transcription factor activity
I6K95_RS07395	COG3181	Tripartite tricarboxylate transporter family receptor
I6K95_RS07420	COG1595	DNA-templated transcription, initiation
I6K95_RS07425	COG3712	iron ion homeostasis
I6K95_RS07430	COG4774	siderophore transport
I6K95_RS07455	COG0180	Tryptophanyl-tRNA synthetase
I6K95_RS07460	COG2183	response to ionizing radiation
I6K95_RS07465	COG1199	ATP-dependent helicase activity
I6K95_RS07475	COG0564	pseudouridine synthase activity
I6K95_RS07485	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6K95_RS07490	COG1028	Short-chain dehydrogenase reductase Sdr
I6K95_RS07495	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
I6K95_RS07510	COG0672	)-iron permease
I6K95_RS07550	COG0583	DNA-binding transcription factor activity
I6K95_RS07560	COG2814	Major facilitator Superfamily
I6K95_RS07570	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6K95_RS07585	COG2084	Dehydrogenase
I6K95_RS07590	COG3181	Tripartite tricarboxylate transporter family receptor
I6K95_RS07615	COG2988	succinylglutamate desuccinylase activity
I6K95_RS07645	COG0765	amino acid transport
I6K95_RS07650	COG0765	amino acid transport
I6K95_RS07655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K95_RS07690	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K95_RS07695	COG1595	DNA-templated transcription, initiation
I6K95_RS07705	COG3530	Putative quorum-sensing-regulated virulence factor
I6K95_RS07710	COG0494	nUDIX hydrolase
I6K95_RS07725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K95_RS07730	COG0542	response to heat
I6K95_RS07750	COG3468	outer membrane autotransporter barrel domain protein
I6K95_RS07760	COG5441	Belongs to the UPF0261 family
I6K95_RS07765	COG5564	TIM-barrel signal transduction protein
I6K95_RS07780	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6K95_RS07795	COG1477	protein flavinylation
I6K95_RS07815	COG1131	(ABC) transporter
I6K95_RS07820	COG0842	Transport permease protein
I6K95_RS07830	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6K95_RS07835	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I6K95_RS07835	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I6K95_RS07840	COG1562	ergosterol biosynthetic process
I6K95_RS07845	COG1562	ergosterol biosynthetic process
I6K95_RS07850	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6K95_RS07855	COG1028	Short-chain dehydrogenase reductase Sdr
I6K95_RS07875	COG2304	oxidoreductase activity
I6K95_RS07895	COG0534	Mate efflux family protein
I6K95_RS07905	COG0254	rRNA binding
I6K95_RS07910	COG3483	tryptophan 2,3-dioxygenase activity
I6K95_RS07915	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
I6K95_RS07920	COG2003	Belongs to the UPF0758 family
I6K95_RS07925	COG1047	Peptidyl-prolyl cis-trans
I6K95_RS07930	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6K95_RS07935	COG0625	glutathione transferase activity
I6K95_RS07955	COG0523	cobalamin synthesis protein
I6K95_RS07965	COG0583	DNA-binding transcription factor activity
I6K95_RS07975	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6K95_RS07980	COG1187	pseudouridine synthase activity
I6K95_RS07985	COG0779	Required for maturation of 30S ribosomal subunits
I6K95_RS07990	COG2251	uridine kinase activity
I6K95_RS07990	COG0195	Participates in both transcription termination and antitermination
I6K95_RS07995	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6K95_RS08000	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6K95_RS08005	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6K95_RS08025	COG1611	Belongs to the LOG family
I6K95_RS08040	COG0412	Dienelactone hydrolase
I6K95_RS08045	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6K95_RS08050	COG1760	l-serine dehydratase
I6K95_RS08055	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6K95_RS08060	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6K95_RS08070	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6K95_RS08095	COG2311	Membrane
I6K95_RS08120	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6K95_RS08140	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6K95_RS08155	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6K95_RS08165	COG1653	transport
I6K95_RS08170	COG1175	transmembrane transport
I6K95_RS08175	COG0395	ABC-type sugar transport system, permease component
I6K95_RS08180	COG3842	ATPase activity
I6K95_RS08215	COG2363	Small membrane protein
I6K95_RS08230	COG1464	Belongs to the NlpA lipoprotein family
I6K95_RS08240	COG0688	phosphatidylethanolamine metabolic process
I6K95_RS08255	COG0095	Lipoate-protein ligase
I6K95_RS08270	COG0625	glutathione transferase activity
I6K95_RS08275	COG0386	Belongs to the glutathione peroxidase family
I6K95_RS08295	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K95_RS08325	COG2259	Doxx family
I6K95_RS08340	COG0667	Aldo Keto reductase
I6K95_RS08370	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6K95_RS08390	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6K95_RS08400	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6K95_RS08450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K95_RS08455	COG3568	Endonuclease Exonuclease Phosphatase
I6K95_RS08465	COG1695	Transcriptional regulator
I6K95_RS08485	COG0583	DNA-binding transcription factor activity
I6K95_RS08500	COG1802	Transcriptional regulator
I6K95_RS08510	COG3181	Tripartite tricarboxylate transporter family receptor
I6K95_RS08520	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K95_RS08535	COG0066	3-isopropylmalate dehydratase activity
I6K95_RS08545	COG3181	Tripartite tricarboxylate transporter family receptor
I6K95_RS08550	COG4948	Mandelate Racemase Muconate Lactonizing
I6K95_RS08565	COG1126	abc transporter atp-binding protein
I6K95_RS08570	COG0765	amino acid transport
I6K95_RS08575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K95_RS08615	COG1815	bacterial-type flagellum-dependent cell motility
I6K95_RS08620	COG1558	bacterial-type flagellum-dependent cell motility
I6K95_RS08630	COG1749	Flagellar hook protein flgE
I6K95_RS08645	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6K95_RS08650	COG1706	bacterial-type flagellum-dependent cell motility
I6K95_RS08660	COG1256	bacterial-type flagellum assembly
I6K95_RS08670	COG0840	transmembrane signaling receptor activity
I6K95_RS08675	COG0840	transmembrane signaling receptor activity
I6K95_RS08680	COG0840	transmembrane signaling receptor activity
I6K95_RS08700	COG1338	Plays a role in the flagellum-specific transport system
I6K95_RS08720	COG1580	Controls the rotational direction of flagella during chemotaxis
I6K95_RS08745	COG1157	protein secretion by the type III secretion system
I6K95_RS08755	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6K95_RS08765	COG1677	Flagellar hook-basal body complex protein FliE
I6K95_RS08775	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6K95_RS08810	COG0285	dihydrofolate synthase activity
I6K95_RS08840	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6K95_RS08845	COG0024	Methionine aminopeptidase
I6K95_RS08850	COG0052	Belongs to the universal ribosomal protein uS2 family
I6K95_RS08855	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6K95_RS08860	COG0528	UMP kinase activity
I6K95_RS08865	COG0233	cytoplasmic translational termination
I6K95_RS08870	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6K95_RS08880	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6K95_RS08885	COG0750	zinc metalloprotease
I6K95_RS08890	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K95_RS08895	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6K95_RS08900	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6K95_RS08905	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6K95_RS08915	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6K95_RS08920	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6K95_RS08925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K95_RS08930	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6K95_RS08940	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6K95_RS08940	COG0519	Catalyzes the synthesis of GMP from XMP
I6K95_RS08955	COG0330	HflC and HflK could
I6K95_RS08960	COG3706	GGDEF domain
I6K95_RS08965	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6K95_RS08970	COG2867	negative regulation of translational initiation
I6K95_RS08980	COG1960	acyl-CoA dehydrogenase activity
I6K95_RS08985	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6K95_RS09015	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K95_RS09020	COG0505	Belongs to the CarA family
I6K95_RS09025	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6K95_RS09035	COG0406	alpha-ribazole phosphatase activity
I6K95_RS09045	COG3842	ATPase activity
I6K95_RS09065	COG5001	Diguanylate cyclase
I6K95_RS09070	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6K95_RS09080	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6K95_RS09085	COG0303	'Molybdopterin
I6K95_RS09090	COG0746	molybdenum cofactor guanylyltransferase activity
I6K95_RS09095	COG0489	protein tyrosine kinase activity
I6K95_RS09125	COG3383	formate dehydrogenase (NAD+) activity
I6K95_RS09125	COG0243	molybdopterin cofactor binding
I6K95_RS09160	COG1122	ATPase activity
I6K95_RS09170	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6K95_RS09175	COG0066	3-isopropylmalate dehydratase activity
I6K95_RS09180	COG0473	3-isopropylmalate dehydrogenase activity
I6K95_RS09185	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K95_RS09195	COG0101	tRNA pseudouridine synthase activity
I6K95_RS09200	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6K95_RS09215	COG0135	phosphoribosylanthranilate isomerase activity
I6K95_RS09250	COG2197	response regulator
I6K95_RS09255	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6K95_RS09260	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6K95_RS09265	COG0189	ligase activity
I6K95_RS09275	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K95_RS09280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K95_RS09295	COG2423	ornithine cyclodeaminase activity
I6K95_RS09305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K95_RS09310	COG0765	amino acid transport
I6K95_RS09315	COG0765	amino acid transport
I6K95_RS09320	COG1126	abc transporter atp-binding protein
I6K95_RS09375	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6K95_RS09385	COG2944	sequence-specific DNA binding
I6K95_RS09395	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6K95_RS09400	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6K95_RS09405	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6K95_RS09410	COG0009	L-threonylcarbamoyladenylate synthase
I6K95_RS09415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K95_RS09420	COG1414	Transcriptional regulator
I6K95_RS09435	COG0765	amino acid transport
I6K95_RS09440	COG1126	abc transporter atp-binding protein
I6K95_RS09445	COG0028	Belongs to the TPP enzyme family
I6K95_RS09460	COG0028	Belongs to the TPP enzyme family
I6K95_RS09465	COG0583	DNA-binding transcription factor activity
I6K95_RS09470	COG4974	Belongs to the 'phage' integrase family
I6K95_RS09475	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K95_RS09480	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I6K95_RS09495	COG1686	Belongs to the peptidase S11 family
I6K95_RS09505	COG2814	Major facilitator Superfamily
I6K95_RS09520	COG1074	ATP-dependent DNA helicase activity
I6K95_RS09530	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6K95_RS09535	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6K95_RS09540	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6K95_RS09560	COG2321	neutral zinc metallopeptidase
I6K95_RS09565	COG0009	L-threonylcarbamoyladenylate synthase
I6K95_RS09605	COG3360	Dodecin
I6K95_RS09610	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6K95_RS09615	COG2850	peptidyl-arginine hydroxylation
I6K95_RS09620	COG3539	Fimbrial protein
I6K95_RS09625	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6K95_RS09630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K95_RS09645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K95_RS09650	COG0765	amino acid transport
I6K95_RS09655	COG1126	abc transporter atp-binding protein
I6K95_RS09660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K95_RS09665	COG1758	RNA polymerase activity
I6K95_RS09670	COG0194	GDP metabolic process
I6K95_RS09675	COG3258	Cytochrome c
I6K95_RS09680	COG2863	cytochrome
I6K95_RS09685	COG1028	Short-chain dehydrogenase reductase Sdr
I6K95_RS09690	COG0791	NLP P60 protein
I6K95_RS09695	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6K95_RS09710	COG1561	YicC-like family, N-terminal region
I6K95_RS09715	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6K95_RS09735	COG2200	EAL domain
I6K95_RS09735	COG2199	diguanylate cyclase activity
I6K95_RS09740	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6K95_RS09750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K95_RS09755	COG0174	glutamine synthetase
I6K95_RS09765	COG2204	response regulator
I6K95_RS09770	COG0583	DNA-binding transcription factor activity
I6K95_RS09775	COG1741	Belongs to the pirin family
I6K95_RS09780	COG1741	Belongs to the pirin family
I6K95_RS09790	COG3842	ATPase activity
I6K95_RS09795	COG1178	ABC-type Fe3 transport system permease component
I6K95_RS09800	COG1840	ABC-type Fe3 transport system, periplasmic component
I6K95_RS09810	COG0583	DNA-binding transcription factor activity
I6K95_RS09820	COG0656	L-ascorbic acid biosynthetic process
I6K95_RS09835	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6K95_RS09840	COG0583	DNA-binding transcription factor activity
I6K95_RS09855	COG0783	Belongs to the Dps family
I6K95_RS09870	COG0463	Glycosyl transferase, family 2
I6K95_RS09895	COG0438	transferase activity, transferring glycosyl groups
I6K95_RS09910	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6K95_RS09940	COG3119	arylsulfatase activity
I6K95_RS09975	COG0714	Associated with various cellular activities
I6K95_RS09995	COG1028	Short-chain dehydrogenase reductase Sdr
I6K95_RS10000	COG0861	Integral membrane protein TerC family
I6K95_RS10045	COG0300	oxidoreductase activity
I6K95_RS10065	COG2197	response regulator
I6K95_RS10075	COG2944	sequence-specific DNA binding
I6K95_RS10085	COG0625	glutathione transferase activity
I6K95_RS10115	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K95_RS10120	COG1028	Short-chain dehydrogenase reductase Sdr
I6K95_RS10165	COG0431	NADPH-dependent FMN reductase
I6K95_RS10195	COG1028	Short-chain dehydrogenase reductase Sdr
I6K95_RS10200	COG0583	DNA-binding transcription factor activity
I6K95_RS10220	COG2111	Na H antiporter
I6K95_RS10220	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6K95_RS10225	COG1006	Multisubunit Na H antiporter MnhC subunit
I6K95_RS10230	COG0651	ATP synthesis coupled electron transport
I6K95_RS10235	COG1863	multisubunit Na H antiporter MnhE subunit
I6K95_RS10240	COG2212	antiporter activity
I6K95_RS10265	COG0590	tRNA wobble adenosine to inosine editing
I6K95_RS10270	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6K95_RS10275	COG1024	Enoyl-CoA hydratase
I6K95_RS10290	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6K95_RS10295	COG0488	(ABC) transporter
I6K95_RS10330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K95_RS10340	COG2252	PERMEase
I6K95_RS10345	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6K95_RS10355	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6K95_RS10360	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6K95_RS10390	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6K95_RS10395	COG0789	Transcriptional regulator
I6K95_RS10405	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K95_RS10405	COG0678	peroxiredoxin activity
I6K95_RS10415	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6K95_RS10420	COG0584	glycerophosphoryl diester phosphodiesterase
I6K95_RS10425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K95_RS10445	COG2823	Periplasmic or secreted lipoprotein
I6K95_RS10455	COG3237	CsbD-like
I6K95_RS10460	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K95_RS10460	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6K95_RS10465	COG0189	ligase activity
I6K95_RS10465	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K95_RS10485	COG2833	Protein of unknown function (DUF455)
I6K95_RS10490	COG2951	lytic endotransglycosylase activity
I6K95_RS10505	COG1522	sequence-specific DNA binding
I6K95_RS10515	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6K95_RS10520	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6K95_RS10525	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6K95_RS10530	COG0196	riboflavin kinase activity
I6K95_RS10535	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6K95_RS10560	COG0210	DNA helicase
I6K95_RS10565	COG4771	TonB-dependent receptor
I6K95_RS10570	COG0488	(ABC) transporter
I6K95_RS10575	COG2890	protein-(glutamine-N5) methyltransferase activity
I6K95_RS10580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K95_RS10585	COG2171	N-acyltransferase activity
I6K95_RS10620	COG1278	Cold shock
I6K95_RS10630	COG1278	Cold shock
I6K95_RS10640	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6K95_RS10645	COG0740	serine-type endopeptidase activity
I6K95_RS10650	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6K95_RS10655	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6K95_RS10660	COG0583	DNA-binding transcription factor activity
I6K95_RS10665	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K95_RS10680	COG1024	Enoyl-CoA hydratase
I6K95_RS10690	COG0183	Belongs to the thiolase family
I6K95_RS10695	COG1028	Short-chain dehydrogenase reductase Sdr
I6K95_RS10715	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K95_RS10745	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K95_RS10755	COG0556	nucleotide-excision repair
I6K95_RS10760	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6K95_RS10770	COG1104	cysteine desulfurase activity
I6K95_RS10775	COG0822	iron-sulfur transferase activity
I6K95_RS10780	COG0316	Belongs to the HesB IscA family
I6K95_RS10785	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6K95_RS10790	COG0443	Heat shock 70 kDa protein
I6K95_RS10795	COG0633	Ferredoxin
I6K95_RS10815	COG1024	Enoyl-CoA hydratase
I6K95_RS10835	COG3395	kinase activity
I6K95_RS10855	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6K95_RS10865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K95_RS10895	COG0747	negative chemotaxis
I6K95_RS10900	COG0601	transmembrane transport
I6K95_RS10905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K95_RS10910	COG4172	Belongs to the ABC transporter superfamily
I6K95_RS10915	COG0154	amidase activity
I6K95_RS10960	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6K95_RS10965	COG0425	Belongs to the sulfur carrier protein TusA family
I6K95_RS10975	COG0228	four-way junction DNA binding
I6K95_RS10980	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6K95_RS10985	COG0336	Belongs to the RNA methyltransferase TrmD family
I6K95_RS10990	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6K95_RS11015	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6K95_RS11020	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6K95_RS11025	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6K95_RS11030	COG0084	hydrolase, TatD family'
I6K95_RS11045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K95_RS11055	COG1126	abc transporter atp-binding protein
I6K95_RS11065	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K95_RS11080	COG0028	Belongs to the TPP enzyme family
I6K95_RS11090	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6K95_RS11090	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6K95_RS11100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6K95_RS11145	COG4336	lyase activity
I6K95_RS11155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K95_RS11155	COG2205	protein histidine kinase activity
I6K95_RS11160	COG2197	response regulator
I6K95_RS11165	COG3210	domain, Protein
I6K95_RS11165	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
I6K95_RS11165	COG3064	Membrane
I6K95_RS11175	COG3121	Chaperone
I6K95_RS11180	COG3188	usher protein
I6K95_RS11185	COG3539	Fimbrial protein
I6K95_RS11190	COG2831	hemolysin activation secretion protein
I6K95_RS11205	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6K95_RS11255	COG0668	transmembrane transport
I6K95_RS11275	COG0483	inositol monophosphate 1-phosphatase activity
I6K95_RS11280	COG1253	flavin adenine dinucleotide binding
I6K95_RS11285	COG1968	undecaprenyl-diphosphatase activity
I6K95_RS11290	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6K95_RS11305	COG0215	cysteine-tRNA ligase activity
I6K95_RS11315	COG0825	malonyl-CoA metabolic process
I6K95_RS11325	COG0037	tRNA processing
I6K95_RS11330	COG0527	aspartate kinase activity
I6K95_RS11355	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K95_RS11360	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6K95_RS11360	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6K95_RS11375	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6K95_RS11380	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
I6K95_RS11385	COG1028	Short-chain dehydrogenase reductase Sdr
I6K95_RS11395	COG0583	DNA-binding transcription factor activity
I6K95_RS11420	COG3842	ATPase activity
I6K95_RS11430	COG1902	pentaerythritol trinitrate reductase activity
I6K95_RS11430	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6K95_RS11435	COG1414	Transcriptional regulator
I6K95_RS11440	COG1832	CoA-binding protein
I6K95_RS11450	COG0251	oxidation-reduction process
I6K95_RS11475	COG1902	pentaerythritol trinitrate reductase activity
I6K95_RS11485	COG1215	transferase activity, transferring glycosyl groups
I6K95_RS11490	COG0726	polysaccharide deacetylase
I6K95_RS11490	COG1649	PFAM Uncharacterised BCR, COG1649
I6K95_RS11510	COG1846	Transcriptional regulator
I6K95_RS11545	COG2080	2 iron, 2 sulfur cluster binding
I6K95_RS11550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K95_RS11555	COG3473	Maleate cis-trans isomerase
I6K95_RS11565	COG2309	aminopeptidase activity
I6K95_RS11570	COG1335	isochorismatase
I6K95_RS11585	COG1017	nitric oxide dioxygenase activity
I6K95_RS11585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K95_RS11600	COG3181	Tripartite tricarboxylate transporter family receptor
I6K95_RS11630	COG0166	Belongs to the GPI family
I6K95_RS11635	COG1045	serine acetyltransferase
I6K95_RS11645	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6K95_RS11650	COG0483	inositol monophosphate 1-phosphatase activity
I6K95_RS11655	COG1012	belongs to the aldehyde dehydrogenase family
I6K95_RS11660	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K95_RS11675	COG0210	DNA helicase
I6K95_RS11680	COG0598	Magnesium transport protein CorA
I6K95_RS11690	COG0747	negative chemotaxis
I6K95_RS11695	COG0601	transmembrane transport
I6K95_RS11700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K95_RS11705	COG4172	Belongs to the ABC transporter superfamily
I6K95_RS11710	COG1846	Transcriptional regulator
I6K95_RS11755	COG4964	Belongs to the GSP D family
I6K95_RS11795	COG2204	response regulator
I6K95_RS11810	COG1595	DNA-templated transcription, initiation
I6K95_RS11820	COG3474	cytochrome
I6K95_RS11825	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6K95_RS11840	COG3384	dioxygenase
I6K95_RS11845	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6K95_RS11870	COG2885	chlorophyll binding
I6K95_RS11905	COG0697	spore germination
I6K95_RS11910	COG0730	response to heat
I6K95_RS11925	COG0583	DNA-binding transcription factor activity
I6K95_RS11930	COG0427	acetyl-CoA hydrolase
I6K95_RS11985	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K95_RS11990	COG0154	amidase activity
I6K95_RS12000	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6K95_RS12015	COG0495	leucyl-tRNA aminoacylation
I6K95_RS12020	COG2814	Major facilitator Superfamily
I6K95_RS12045	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6K95_RS12050	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6K95_RS12055	COG2814	Major facilitator Superfamily
I6K95_RS12075	COG4176	ABC-type proline glycine betaine transport system permease component
I6K95_RS12085	COG1942	4-Oxalocrotonate Tautomerase
I6K95_RS12090	COG0183	Belongs to the thiolase family
I6K95_RS12100	COG1802	Transcriptional regulator
I6K95_RS12110	COG1024	Enoyl-CoA hydratase
I6K95_RS12125	COG2032	superoxide dismutase activity
I6K95_RS12140	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6K95_RS12165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K95_RS12170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K95_RS12180	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6K95_RS12185	COG0736	holo-[acyl-carrier-protein] synthase activity
I6K95_RS12190	COG1472	Belongs to the glycosyl hydrolase 3 family
I6K95_RS12195	COG0322	excinuclease ABC activity
I6K95_RS12200	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6K95_RS12210	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6K95_RS12210	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6K95_RS12215	COG2224	Isocitrate lyase
I6K95_RS12235	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6K95_RS12245	COG4638	Rieske (2fe-2S)
I6K95_RS12255	COG1024	Enoyl-CoA hydratase
I6K95_RS12265	COG0633	Ferredoxin
I6K95_RS12270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K95_RS12285	COG0183	Belongs to the thiolase family
I6K95_RS12300	COG0583	DNA-binding transcription factor activity
I6K95_RS12325	COG2346	COG2346, Truncated hemoglobins
I6K95_RS12445	COG2207	Transcriptional regulator
I6K95_RS12495	COG1132	(ABC) transporter
I6K95_RS12520	COG0659	secondary active sulfate transmembrane transporter activity
I6K95_RS12550	COG2169	Transcriptional regulator
I6K95_RS12555	COG5507	3-demethylubiquinone-9 3-methyltransferase
I6K95_RS12560	COG0384	phenazine biosynthesis protein PhzF
I6K95_RS12565	COG0583	DNA-binding transcription factor activity
I6K95_RS12570	COG2733	membrane
I6K95_RS12585	COG1012	belongs to the aldehyde dehydrogenase family
I6K95_RS12590	COG3284	Transcriptional regulator
I6K95_RS12605	COG1380	Effector of murein hydrolase LrgA
I6K95_RS12610	COG4106	trans-aconitate 2-methyltransferase activity
I6K95_RS12610	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6K95_RS12620	COG0156	8-amino-7-oxononanoate synthase activity
I6K95_RS12690	COG1131	(ABC) transporter
I6K95_RS12695	COG0842	Transport permease protein
I6K95_RS12700	COG0628	permease
I6K95_RS12725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K95_RS12740	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6K95_RS12745	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6K95_RS12750	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6K95_RS12755	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I6K95_RS12760	COG0330	HflC and HflK could
I6K95_RS12765	COG0330	HflC and HflK could
I6K95_RS12770	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6K95_RS12775	COG1923	regulation of RNA biosynthetic process
I6K95_RS12780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6K95_RS12785	COG1160	GTP binding
I6K95_RS12790	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K95_RS12795	COG2976	Protein conserved in bacteria
I6K95_RS12800	COG0124	histidyl-tRNA synthetase
I6K95_RS12805	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6K95_RS12815	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6K95_RS12820	COG0105	UTP biosynthetic process
I6K95_RS12825	COG0525	valine-tRNA ligase activity
I6K95_RS12840	COG0642	Histidine kinase
I6K95_RS12855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K95_RS12860	COG1959	2 iron, 2 sulfur cluster binding
I6K95_RS12865	COG1017	nitric oxide dioxygenase activity
I6K95_RS12865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K95_RS12895	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K95_RS12900	COG2358	TRAP transporter, solute receptor (TAXI family
I6K95_RS12930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K95_RS12935	COG1366	Belongs to the anti-sigma-factor antagonist family
I6K95_RS12940	COG2172	sigma factor antagonist activity
I6K95_RS12945	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6K95_RS12955	COG2770	Histidine kinase
I6K95_RS12955	COG2208	phosphoserine phosphatase activity
I6K95_RS12980	COG1595	DNA-templated transcription, initiation
I6K95_RS12995	COG4792	protein secretion
I6K95_RS13000	COG4791	protein targeting
I6K95_RS13005	COG4794	Type iii secretion
I6K95_RS13010	COG4790	Type iii secretion
I6K95_RS13045	COG4669	(LipO)protein
I6K95_RS13110	COG4789	Type iii secretion
I6K95_RS13140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K95_RS13145	COG0840	transmembrane signaling receptor activity
I6K95_RS13150	COG2233	PERMEase
I6K95_RS13175	COG1840	ABC-type Fe3 transport system, periplasmic component
I6K95_RS13180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K95_RS13185	COG1178	ABC-type Fe3 transport system permease component
I6K95_RS13190	COG3842	ATPase activity
I6K95_RS13195	COG0583	DNA-binding transcription factor activity
I6K95_RS13215	COG0501	Belongs to the peptidase M48B family
I6K95_RS13225	COG0697	spore germination
I6K95_RS13235	COG1846	Transcriptional regulator
I6K95_RS13245	COG1566	PFAM secretion protein HlyD family protein
I6K95_RS13250	COG2814	Major facilitator Superfamily
I6K95_RS13255	COG0473	3-isopropylmalate dehydrogenase activity
I6K95_RS13265	COG0747	negative chemotaxis
I6K95_RS13275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K95_RS13290	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K95_RS13315	COG1012	belongs to the aldehyde dehydrogenase family
I6K95_RS13325	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K95_RS13330	COG1115	amino acid carrier protein
I6K95_RS13335	COG0433	COG0433 Predicted ATPase
I6K95_RS13340	COG0217	transcriptional regulatory protein
I6K95_RS13345	COG0151	Belongs to the GarS family
I6K95_RS13350	COG0408	coproporphyrinogen oxidase activity
I6K95_RS13355	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6K95_RS13360	COG0799	negative regulation of ribosome biogenesis
I6K95_RS13365	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6K95_RS13370	COG0424	maF-like protein
I6K95_RS13375	COG3468	outer membrane autotransporter barrel domain protein
I6K95_RS13410	COG1530	ribonuclease E activity
I6K95_RS13415	COG0077	Prephenate dehydratase
I6K95_RS13430	COG1132	(ABC) transporter
I6K95_RS13435	COG0859	PFAM glycosyl transferase family 9
I6K95_RS13460	COG2194	sulfuric ester hydrolase activity
I6K95_RS13465	COG0438	transferase activity, transferring glycosyl groups
I6K95_RS13470	COG0463	Glycosyl transferase, family 2
I6K95_RS13475	COG0726	polysaccharide deacetylase
I6K95_RS13480	COG0438	transferase activity, transferring glycosyl groups
I6K95_RS13495	COG1643	Atp-dependent helicase
I6K95_RS13500	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6K95_RS13500	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6K95_RS13505	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6K95_RS13515	COG0704	Plays a role in the regulation of phosphate uptake
I6K95_RS13520	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6K95_RS13525	COG1960	acyl-CoA dehydrogenase activity
I6K95_RS13550	COG1177	transmembrane transport
I6K95_RS13555	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K95_RS13560	COG3842	ATPase activity
I6K95_RS13565	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K95_RS13580	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6K95_RS13585	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6K95_RS13595	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6K95_RS13595	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6K95_RS13610	COG0372	Belongs to the citrate synthase family
I6K95_RS13615	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6K95_RS13620	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K95_RS13625	COG1053	succinate dehydrogenase
I6K95_RS13630	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6K95_RS13635	COG2009	succinate dehydrogenase
I6K95_RS13640	COG2188	Transcriptional regulator
I6K95_RS13645	COG0039	L-malate dehydrogenase activity
I6K95_RS13675	COG1981	membrane
I6K95_RS13700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K95_RS13710	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6K95_RS13740	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6K95_RS13745	COG0148	phosphopyruvate hydratase activity
I6K95_RS13755	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6K95_RS13760	COG0504	CTP synthase activity
I6K95_RS13785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K95_RS13795	COG0747	negative chemotaxis
I6K95_RS13800	COG4172	Belongs to the ABC transporter superfamily
I6K95_RS13805	COG1446	asparaginase
I6K95_RS13835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6K95_RS13850	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6K95_RS13855	COG0697	spore germination
I6K95_RS13860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K95_RS13870	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6K95_RS13880	COG0791	NLP P60 protein
I6K95_RS13895	COG0583	DNA-binding transcription factor activity
I6K95_RS13910	COG0583	DNA-binding transcription factor activity
I6K95_RS13920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6K95_RS13935	COG0670	Belongs to the BI1 family
I6K95_RS13940	COG3181	Tripartite tricarboxylate transporter family receptor
I6K95_RS13965	COG1381	Involved in DNA repair and RecF pathway recombination
I6K95_RS13970	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6K95_RS13975	COG0571	ribonuclease III activity
I6K95_RS13980	COG0681	Belongs to the peptidase S26 family
I6K95_RS13985	COG0481	GTPase activity
I6K95_RS13990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K95_RS14015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K95_RS14020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6K95_RS14035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6K95_RS14040	COG0416	fatty acid biosynthetic process
I6K95_RS14045	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6K95_RS14050	COG1399	metal-binding, possibly nucleic acid-binding protein
I6K95_RS14055	COG0424	maF-like protein
I6K95_RS14065	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K95_RS14080	COG3022	response to hydroperoxide
I6K95_RS14090	COG1028	Short-chain dehydrogenase reductase Sdr
I6K95_RS14105	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I6K95_RS14135	COG2814	Major facilitator Superfamily
I6K95_RS14155	COG3706	GGDEF domain
I6K95_RS14180	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6K95_RS14185	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6K95_RS14190	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6K95_RS14195	COG1674	ftsk spoiiie
I6K95_RS14200	COG0492	ferredoxin-NADP+ reductase activity
I6K95_RS14205	COG1193	negative regulation of DNA recombination
I6K95_RS14220	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6K95_RS14235	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6K95_RS14240	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6K95_RS14245	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6K95_RS14255	COG0745	RESPONSE REGULATOR receiver
I6K95_RS14300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6K95_RS14320	COG0612	Peptidase, M16
I6K95_RS14325	COG0484	heat shock protein binding
I6K95_RS14330	COG0443	Heat shock 70 kDa protein
I6K95_RS14340	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6K95_RS14350	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6K95_RS14355	COG1420	regulation of RNA biosynthetic process
I6K95_RS14360	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6K95_RS14365	COG0497	DNA recombination
I6K95_RS14370	COG0735	belongs to the Fur family
I6K95_RS14375	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K95_RS14380	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6K95_RS14385	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6K95_RS14420	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6K95_RS14420	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6K95_RS14425	COG4311	Sarcosine oxidase, delta subunit
I6K95_RS14430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K95_RS14440	COG0583	DNA-binding transcription factor activity
I6K95_RS14450	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6K95_RS14475	COG4964	Belongs to the GSP D family
I6K95_RS14535	COG0181	hydroxymethylbilane synthase activity
I6K95_RS14540	COG0861	Integral membrane protein TerC family
I6K95_RS14545	COG0861	Integral membrane protein TerC family
I6K95_RS14550	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K95_RS14555	COG0045	succinate-CoA ligase (ADP-forming) activity
I6K95_RS14565	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6K95_RS14575	COG2137	regulation of response to DNA damage stimulus
I6K95_RS14580	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6K95_RS14600	COG1024	Enoyl-CoA hydratase
I6K95_RS14600	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K95_RS14605	COG3842	ATPase activity
I6K95_RS14620	COG1028	Short-chain dehydrogenase reductase Sdr
I6K95_RS14640	COG0583	DNA-binding transcription factor activity
I6K95_RS14645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K95_RS14655	COG2974	May be involved in recombination
I6K95_RS14660	COG0540	Belongs to the ATCase OTCase family
I6K95_RS14725	COG0776	regulation of translation
I6K95_RS14730	COG0072	phenylalanine-tRNA ligase activity
I6K95_RS14730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K95_RS14735	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6K95_RS14740	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6K95_RS14745	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6K95_RS14760	COG0756	dUTP diphosphatase activity
I6K95_RS14770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K95_RS14785	COG0500	methyltransferase
I6K95_RS14795	COG0586	Pfam SNARE associated Golgi protein
I6K95_RS14825	COG1609	Transcriptional regulator
I6K95_RS14830	COG4172	Belongs to the ABC transporter superfamily
I6K95_RS14835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K95_RS14840	COG0601	transmembrane transport
I6K95_RS14845	COG0747	negative chemotaxis
I6K95_RS14860	COG1280	lysine exporter protein (LysE YggA)
I6K95_RS14875	COG2814	Major facilitator Superfamily
I6K95_RS14905	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6K95_RS14920	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6K95_RS14945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K95_RS14950	COG1116	anion transmembrane transporter activity
I6K95_RS14960	COG1228	amidohydrolase
I6K95_RS14975	COG0477	Major facilitator Superfamily
I6K95_RS14985	COG3550	peptidyl-serine autophosphorylation
I6K95_RS14995	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6K95_RS14995	COG0519	Catalyzes the synthesis of GMP from XMP
I6K95_RS15035	COG0420	3'-5' exonuclease activity
I6K95_RS15040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K95_RS15070	COG0395	ABC-type sugar transport system, permease component
I6K95_RS15080	COG3842	ATPase activity
I6K95_RS15110	COG3181	Tripartite tricarboxylate transporter family receptor
I6K95_RS15145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K95_RS15170	COG0602	queuosine metabolic process
I6K95_RS15175	COG0720	synthase
I6K95_RS15180	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6K95_RS15185	COG0235	Class ii aldolase
I6K95_RS15210	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
I6K95_RS15210	COG3210	domain, Protein
I6K95_RS15210	COG3064	Membrane
I6K95_RS15215	COG0047	phosphoribosylformylglycinamidine synthase activity
I6K95_RS15215	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6K95_RS15220	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6K95_RS15225	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6K95_RS15225	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6K95_RS15230	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6K95_RS15250	COG3539	Fimbrial protein
I6K95_RS15260	COG2050	protein possibly involved in aromatic compounds catabolism
I6K95_RS15265	COG1024	Enoyl-CoA hydratase
I6K95_RS15270	COG1012	belongs to the aldehyde dehydrogenase family
I6K95_RS15285	COG2151	metal-sulfur cluster biosynthetic enzyme
I6K95_RS15290	COG3396	Phenylacetate-CoA oxygenase
I6K95_RS15295	COG3460	Phenylacetate-CoA oxygenase
I6K95_RS15300	COG3396	Phenylacetate-CoA oxygenase
I6K95_RS15305	COG3327	negative regulation of DNA-templated transcription, initiation
I6K95_RS15315	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6K95_RS15320	COG0501	Belongs to the peptidase M48B family
I6K95_RS15325	COG1162	GTPase activity
I6K95_RS15340	COG0601	transmembrane transport
I6K95_RS15345	COG0747	negative chemotaxis
I6K95_RS15390	COG0668	transmembrane transport
I6K95_RS15395	COG0165	Argininosuccinate lyase
I6K95_RS15415	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6K95_RS15420	COG0303	'Molybdopterin
I6K95_RS15425	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K95_RS15440	COG0315	cyclic pyranopterin monophosphate synthase activity
I6K95_RS15450	COG0412	Dienelactone hydrolase
I6K95_RS15460	COG0678	peroxiredoxin activity
I6K95_RS15470	COG0697	spore germination
I6K95_RS15475	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6K95_RS15500	COG0789	Transcriptional regulator
I6K95_RS15515	COG1028	Short-chain dehydrogenase reductase Sdr
I6K95_RS15525	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6K95_RS15530	COG1845	cytochrome c oxidase, subunit III
I6K95_RS15535	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6K95_RS15545	COG0477	Major facilitator Superfamily
I6K95_RS15580	COG1309	transcriptional regulator
I6K95_RS15585	COG2271	Major facilitator Superfamily
I6K95_RS15620	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K95_RS15620	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K95_RS15620	COG0506	proline dehydrogenase activity
I6K95_RS15630	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K95_RS15630	COG3008	intermembrane lipid transfer
I6K95_RS15635	COG2995	paraquat-inducible protein a
I6K95_RS15640	COG0542	response to heat
I6K95_RS15645	COG4953	penicillin-binding protein 1C
I6K95_RS15655	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6K95_RS15660	COG1278	Cold shock
I6K95_RS15670	COG0183	Belongs to the thiolase family
I6K95_RS15675	COG0038	chloride channel
I6K95_RS15680	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6K95_RS15685	COG1570	exodeoxyribonuclease VII activity
I6K95_RS15695	COG0811	peptide transport
I6K95_RS15700	COG0848	biopolymer transport protein
I6K95_RS15705	COG1663	tetraacyldisaccharide 4'-kinase activity
I6K95_RS15710	COG2835	tetraacyldisaccharide 4'-kinase activity
I6K95_RS15715	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6K95_RS15720	COG0563	adenylate kinase activity
I6K95_RS15730	COG0728	peptidoglycan biosynthetic process
I6K95_RS15740	COG0268	Binds directly to 16S ribosomal RNA
I6K95_RS15770	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6K95_RS15795	COG0436	Aminotransferase
I6K95_RS15800	COG3737	Protein of unknown function (DUF498/DUF598)
I6K95_RS15805	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6K95_RS15810	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6K95_RS15815	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6K95_RS15825	COG0305	Participates in initiation and elongation during chromosome replication
I6K95_RS15835	COG0359	binds to the 23S rRNA
I6K95_RS15840	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6K95_RS15845	COG2965	DNA replication, synthesis of RNA primer
I6K95_RS15850	COG0360	Binds together with S18 to 16S ribosomal RNA
I6K95_RS15855	COG1469	GTP cyclohydrolase I activity
I6K95_RS15860	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6K95_RS15865	COG0142	geranyltranstransferase activity
I6K95_RS15870	COG1722	exodeoxyribonuclease VII activity
I6K95_RS15880	COG3181	Tripartite tricarboxylate transporter family receptor
I6K95_RS15900	COG2239	Acts as a magnesium transporter
I6K95_RS15910	COG2855	membrane
I6K95_RS15920	COG1473	amidohydrolase
I6K95_RS15925	COG0318	PFAM AMP-dependent synthetase and ligase
I6K95_RS15945	COG1501	Belongs to the glycosyl hydrolase 31 family
I6K95_RS15950	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6K95_RS15955	COG2011	ABC-type metal ion transport system permease component
I6K95_RS15975	COG1454	alcohol dehydrogenase
I6K95_RS16000	COG2186	Transcriptional regulator
I6K95_RS16005	COG3181	Tripartite tricarboxylate transporter family receptor
I6K95_RS16025	COG1175	transmembrane transport
I6K95_RS16030	COG0395	ABC-type sugar transport system, permease component
I6K95_RS16035	COG3842	ATPase activity
I6K95_RS16055	COG1653	transport
I6K95_RS16075	COG2818	Glycosylase
I6K95_RS16080	COG2982	Protein involved in outer membrane biogenesis
I6K95_RS16085	COG1309	transcriptional regulator
I6K95_RS16090	COG1028	Short-chain dehydrogenase reductase Sdr
I6K95_RS16135	COG0583	DNA-binding transcription factor activity
I6K95_RS16140	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6K95_RS16145	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K95_RS16160	COG1028	Short-chain dehydrogenase reductase Sdr
I6K95_RS16165	COG0477	Major facilitator Superfamily
I6K95_RS16175	COG0583	DNA-binding transcription factor activity
I6K95_RS16180	COG1448	Aminotransferase
I6K95_RS16185	COG1418	mRNA catabolic process
I6K95_RS16210	COG1063	alcohol dehydrogenase
I6K95_RS16230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K95_RS16240	COG0318	PFAM AMP-dependent synthetase and ligase
I6K95_RS16250	COG1522	sequence-specific DNA binding
I6K95_RS16255	COG3181	Tripartite tricarboxylate transporter family receptor
I6K95_RS16260	COG0307	riboflavin synthase, alpha
I6K95_RS16265	COG0154	amidase activity
I6K95_RS16290	COG2807	transmembrane transport
I6K95_RS16295	COG0590	tRNA wobble adenosine to inosine editing
I6K95_RS16305	COG0583	DNA-binding transcription factor activity
I6K95_RS16340	COG3909	cytochrome
I6K95_RS16345	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6K95_RS16350	COG0625	glutathione transferase activity
I6K95_RS16355	COG0730	response to heat
I6K95_RS16360	COG0482	sulfurtransferase activity
I6K95_RS16365	COG0583	DNA-binding transcription factor activity
I6K95_RS16405	COG2819	hydrolase of the alpha beta superfamily
I6K95_RS16410	COG0247	lactate metabolic process
I6K95_RS16415	COG0277	FAD linked oxidase domain protein
I6K95_RS16420	COG0277	FAD linked oxidase domain protein
I6K95_RS16425	COG0277	FAD linked oxidase domain protein
I6K95_RS16430	COG3210	domain, Protein
I6K95_RS16430	COG3064	Membrane
I6K95_RS16430	COG3064	Membrane
I6K95_RS16430	COG3210	domain, Protein
I6K95_RS16430	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
I6K95_RS16430	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
I6K95_RS16435	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K95_RS16440	COG0312	modulator of DNA gyrase
I6K95_RS16475	COG1666	GTP binding
I6K95_RS16520	COG3220	belongs to the UPF0276 family
I6K95_RS16540	COG0640	Transcriptional regulator
I6K95_RS16545	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6K95_RS16550	COG1845	cytochrome c oxidase, subunit III
I6K95_RS16555	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6K95_RS16565	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
I6K95_RS16600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K95_RS16605	COG0583	DNA-binding transcription factor activity
I6K95_RS16635	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K95_RS16635	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K95_RS16650	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6K95_RS16655	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6K95_RS16665	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6K95_RS16680	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6K95_RS16685	COG0316	Belongs to the HesB IscA family
I6K95_RS16695	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6K95_RS16700	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6K95_RS16705	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6K95_RS16710	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6K95_RS16715	COG0312	modulator of DNA gyrase
I6K95_RS16720	COG3028	Belongs to the UPF0307 family
I6K95_RS16735	COG1116	anion transmembrane transporter activity
I6K95_RS16740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K95_RS16745	COG1335	isochorismatase
I6K95_RS16750	COG0346	lactoylglutathione lyase activity
I6K95_RS16755	COG0513	Belongs to the DEAD box helicase family
I6K95_RS16760	COG3069	C4-dicarboxylate transmembrane transporter activity
I6K95_RS16765	COG1802	Transcriptional regulator
I6K95_RS16775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K95_RS16775	COG0045	succinate-CoA ligase (ADP-forming) activity
I6K95_RS16775	COG1042	CoA-binding domain protein
I6K95_RS16780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6K95_RS16795	COG1522	sequence-specific DNA binding
I6K95_RS16830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K95_RS16835	COG1696	Membrane protein involved in D-alanine export
I6K95_RS16855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K95_RS16870	COG0439	Biotin carboxylase
I6K95_RS16875	COG0511	ligase activity, forming carbon-carbon bonds
I6K95_RS16880	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6K95_RS16885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K95_RS16890	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6K95_RS16895	COG3150	esterase
I6K95_RS16900	COG0557	exoribonuclease II activity
I6K95_RS16910	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6K95_RS16935	COG1522	sequence-specific DNA binding
I6K95_RS16940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K95_RS16945	COG1028	Short-chain dehydrogenase reductase Sdr
I6K95_RS16965	COG0653	protein targeting
I6K95_RS16970	COG0739	heme binding
I6K95_RS16980	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I6K95_RS16985	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6K95_RS16995	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6K95_RS17000	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6K95_RS17005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6K95_RS17010	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6K95_RS17020	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6K95_RS17025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6K95_RS17030	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K95_RS17040	COG3116	cell division
I6K95_RS17045	COG0275	rRNA processing
I6K95_RS17050	COG2001	Belongs to the MraZ family
I6K95_RS17060	COG0488	(ABC) transporter
I6K95_RS17065	COG0418	dihydroorotase activity
I6K95_RS17070	COG1473	amidohydrolase
I6K95_RS17120	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6K95_RS17125	COG4654	Cytochrome c, class I
I6K95_RS17130	COG0129	dihydroxy-acid dehydratase activity
I6K95_RS17135	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6K95_RS17185	COG2084	Dehydrogenase
I6K95_RS17200	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6K95_RS17205	COG0513	Belongs to the DEAD box helicase family
I6K95_RS17215	COG0617	tRNA 3'-terminal CCA addition
I6K95_RS17230	COG0477	Major facilitator Superfamily
I6K95_RS17240	COG0583	DNA-binding transcription factor activity
I6K95_RS17255	COG1950	PFAM Membrane protein of
I6K95_RS17260	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6K95_RS17275	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6K95_RS17285	COG1560	Kdo2-lipid A biosynthetic process
I6K95_RS17290	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6K95_RS17300	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6K95_RS17310	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6K95_RS17320	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6K95_RS17340	COG0735	belongs to the Fur family
I6K95_RS17345	COG0523	cobalamin synthesis protein
I6K95_RS17355	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6K95_RS17360	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6K95_RS17370	COG2096	Adenosyltransferase
I6K95_RS17385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K95_RS17390	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6K95_RS17430	COG4772	TonB-dependent receptor
I6K95_RS17460	COG0405	Gamma-glutamyltransferase
I6K95_RS17470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K95_RS17515	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6K95_RS17535	COG0582	viral genome integration into host DNA
I6K95_RS17540	COG0012	GTP binding
I6K95_RS17550	COG0193	aminoacyl-tRNA hydrolase activity
I6K95_RS17555	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6K95_RS17560	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6K95_RS17570	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6K95_RS17575	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6K95_RS17585	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6K95_RS17610	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I6K95_RS17620	COG1368	sulfuric ester hydrolase activity
I6K95_RS17625	COG0642	Histidine kinase
I6K95_RS17630	COG0745	RESPONSE REGULATOR receiver
I6K95_RS17635	COG0277	FAD linked oxidase domain protein
I6K95_RS17650	COG0166	Belongs to the GPI family
I6K95_RS17655	COG0438	transferase activity, transferring glycosyl groups
I6K95_RS17660	COG0438	transferase activity, transferring glycosyl groups
I6K95_RS17675	COG0438	transferase activity, transferring glycosyl groups
I6K95_RS17690	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6K95_RS17695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6K95_RS17700	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
I6K95_RS17710	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6K95_RS17720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K95_RS17725	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K95_RS17735	COG0747	negative chemotaxis
I6K95_RS17740	COG0601	transmembrane transport
I6K95_RS17745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K95_RS17765	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6K95_RS17770	COG0830	nickel cation binding
I6K95_RS17780	COG0804	urea catabolic process
I6K95_RS17785	COG0832	Belongs to the urease beta subunit family
I6K95_RS17795	COG0831	urea catabolic process
I6K95_RS17800	COG0829	nickel cation binding
I6K95_RS17830	COG2188	Transcriptional regulator
I6K95_RS17855	COG2719	SpoVR family
I6K95_RS17860	COG2718	Belongs to the UPF0229 family
I6K95_RS17885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K95_RS17900	COG1960	acyl-CoA dehydrogenase activity
I6K95_RS17950	COG2030	dehydratase
I6K95_RS17995	COG0328	RNA-DNA hybrid ribonuclease activity
I6K95_RS18000	COG2226	methyltransferase
I6K95_RS18005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K95_RS18010	COG1388	LysM domain
I6K95_RS18010	COG0741	lytic transglycosylase activity
I6K95_RS18030	COG2979	Protein of unknown function (DUF533)
I6K95_RS18065	COG1271	oxidase subunit
I6K95_RS18070	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6K95_RS18075	COG0850	regulation of cytokinetic process
I6K95_RS18080	COG2894	cell division
I6K95_RS18085	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6K95_RS18120	COG0601	transmembrane transport
I6K95_RS18130	COG1215	transferase activity, transferring glycosyl groups
I6K95_RS18140	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6K95_RS18150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6K95_RS18170	COG0318	PFAM AMP-dependent synthetase and ligase
I6K95_RS18175	COG2188	Transcriptional regulator
I6K95_RS18180	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6K95_RS18185	COG2814	Major facilitator Superfamily
I6K95_RS18195	COG0259	pyridoxamine-phosphate oxidase activity
I6K95_RS18200	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K95_RS18215	COG0583	DNA-binding transcription factor activity
I6K95_RS18245	COG0134	indole-3-glycerol-phosphate synthase activity
I6K95_RS18250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K95_RS18255	COG0512	Glutamine amidotransferase of anthranilate synthase
I6K95_RS18265	COG0546	phosphoglycolate phosphatase activity
I6K95_RS18270	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K95_RS18275	COG2967	ApaG domain
I6K95_RS18280	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6K95_RS18285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K95_RS18290	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K95_RS18295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K95_RS18305	COG0037	tRNA processing
I6K95_RS18315	COG3634	alkyl hydroperoxide reductase activity
I6K95_RS18320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K95_RS18325	COG1024	Enoyl-CoA hydratase
I6K95_RS18350	COG0356	it plays a direct role in the translocation of protons across the membrane
I6K95_RS18360	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6K95_RS18365	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6K95_RS18370	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6K95_RS18375	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6K95_RS18380	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6K95_RS18385	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6K95_RS18395	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6K95_RS18400	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6K95_RS18405	COG0210	DNA helicase
I6K95_RS18415	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6K95_RS18425	COG4172	Belongs to the ABC transporter superfamily
I6K95_RS18430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K95_RS18435	COG0601	transmembrane transport
I6K95_RS18455	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6K95_RS18460	COG1024	Enoyl-CoA hydratase
I6K95_RS18465	COG1024	Enoyl-CoA hydratase
I6K95_RS18520	COG2132	Multicopper oxidase
I6K95_RS18530	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K95_RS18530	COG1024	Enoyl-CoA hydratase
I6K95_RS18540	COG1414	Transcriptional regulator
I6K95_RS18550	COG0154	amidase activity
I6K95_RS18570	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6K95_RS18580	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6K95_RS18590	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6K95_RS18595	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K95_RS18600	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6K95_RS18605	COG1929	Belongs to the glycerate kinase type-1 family
I6K95_RS18610	COG0469	pyruvate kinase activity
I6K95_RS18615	COG0700	Nucleoside recognition
I6K95_RS18645	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6K95_RS18650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K95_RS18665	COG0823	Involved in the tonB-independent uptake of proteins
I6K95_RS18675	COG0848	biopolymer transport protein
I6K95_RS18680	COG0811	peptide transport
I6K95_RS18685	COG0824	Thioesterase
I6K95_RS18690	COG0442	prolyl-tRNA aminoacylation
I6K95_RS18695	COG0494	nUDIX hydrolase
I6K95_RS18710	COG2135	peptidase activity
I6K95_RS18780	COG1196	nuclear chromosome segregation
I6K95_RS18925	COG0513	Belongs to the DEAD box helicase family
I6K95_RS18955	COG0429	hydrolase of the alpha beta-hydrolase fold
I6K95_RS18960	COG4783	chaperone-mediated protein folding
I6K95_RS18975	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K95_RS19005	COG0006	proline dipeptidase activity
I6K95_RS19015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K95_RS19035	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6K95_RS19040	COG0632	four-way junction helicase activity
I6K95_RS19055	COG2255	four-way junction helicase activity
I6K95_RS19060	COG0514	ATP-dependent DNA helicase (RecQ)
I6K95_RS19075	COG0288	reversible hydration of carbon dioxide
I6K95_RS19080	COG0154	amidase activity
I6K95_RS19090	COG4211	Belongs to the binding-protein-dependent transport system permease family
I6K95_RS19120	COG1464	Belongs to the NlpA lipoprotein family
I6K95_RS19135	COG1546	Belongs to the CinA family
I6K95_RS19135	COG1058	Belongs to the CinA family
I6K95_RS19140	COG1414	Transcriptional regulator
I6K95_RS19160	COG0167	dihydroorotate dehydrogenase activity
I6K95_RS19165	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I6K95_RS19180	COG0583	DNA-binding transcription factor activity
I6K95_RS19240	COG0281	malic enzyme
I6K95_RS19240	COG0280	phosphate acetyltransferase
I6K95_RS19250	COG0601	transmembrane transport
I6K95_RS19255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K95_RS19260	COG4172	Belongs to the ABC transporter superfamily
I6K95_RS19290	COG0640	Transcriptional regulator
I6K95_RS19305	COG3135	benzoate transporter
I6K95_RS19310	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K95_RS19315	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6K95_RS19320	COG0742	ribosomal rna small subunit methyltransferase
I6K95_RS19335	COG3639	organic phosphonate transmembrane transporter activity
I6K95_RS19340	COG3639	organic phosphonate transmembrane transporter activity
I6K95_RS19380	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6K95_RS19385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6K95_RS19395	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6K95_RS19400	COG1546	Belongs to the CinA family
I6K95_RS19400	COG1058	Belongs to the CinA family
I6K95_RS19405	COG0284	orotidine-5'-phosphate decarboxylase activity
I6K95_RS19410	COG1252	NADH dehydrogenase
I6K95_RS19425	COG3468	outer membrane autotransporter barrel domain protein
I6K95_RS19430	COG0459	protein refolding
I6K95_RS19435	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6K95_RS19455	COG1053	succinate dehydrogenase
I6K95_RS19465	COG0583	DNA-binding transcription factor activity
I6K95_RS19470	COG1053	succinate dehydrogenase
I6K95_RS19485	COG3706	GGDEF domain
I6K95_RS19535	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I6K95_RS19545	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K95_RS19565	COG0069	glutamate synthase activity
I6K95_RS19570	COG2391	methyltransferase activity
I6K95_RS19575	COG0679	Auxin Efflux Carrier
I6K95_RS19600	COG0557	exoribonuclease II activity
I6K95_RS19605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family