locus-tag	class	description
I6K98_RS00090	COG2346	COG2346, Truncated hemoglobins
I6K98_RS00115	COG0583	DNA-binding transcription factor activity
I6K98_RS00130	COG0183	Belongs to the thiolase family
I6K98_RS00145	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K98_RS00150	COG0633	Ferredoxin
I6K98_RS00160	COG1024	Enoyl-CoA hydratase
I6K98_RS00170	COG4638	Rieske (2fe-2S)
I6K98_RS00180	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6K98_RS00200	COG2224	Isocitrate lyase
I6K98_RS00205	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6K98_RS00205	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6K98_RS00215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6K98_RS00220	COG0322	excinuclease ABC activity
I6K98_RS00225	COG1472	Belongs to the glycosyl hydrolase 3 family
I6K98_RS00230	COG0736	holo-[acyl-carrier-protein] synthase activity
I6K98_RS00235	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6K98_RS00245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K98_RS00250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K98_RS00275	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6K98_RS00290	COG2032	superoxide dismutase activity
I6K98_RS00305	COG1024	Enoyl-CoA hydratase
I6K98_RS00315	COG1802	Transcriptional regulator
I6K98_RS00325	COG0183	Belongs to the thiolase family
I6K98_RS00330	COG1942	4-Oxalocrotonate Tautomerase
I6K98_RS00340	COG4176	ABC-type proline glycine betaine transport system permease component
I6K98_RS00360	COG2814	Major facilitator Superfamily
I6K98_RS00365	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6K98_RS00370	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6K98_RS00395	COG2814	Major facilitator Superfamily
I6K98_RS00400	COG0495	leucyl-tRNA aminoacylation
I6K98_RS00415	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6K98_RS00425	COG0154	amidase activity
I6K98_RS00430	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K98_RS00485	COG0427	acetyl-CoA hydrolase
I6K98_RS00490	COG0583	DNA-binding transcription factor activity
I6K98_RS00505	COG0730	response to heat
I6K98_RS00510	COG0697	spore germination
I6K98_RS00545	COG2885	chlorophyll binding
I6K98_RS00570	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6K98_RS00575	COG3384	dioxygenase
I6K98_RS00590	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6K98_RS00595	COG3474	cytochrome
I6K98_RS00605	COG1595	DNA-templated transcription, initiation
I6K98_RS00620	COG2204	response regulator
I6K98_RS00660	COG4964	Belongs to the GSP D family
I6K98_RS00705	COG1846	Transcriptional regulator
I6K98_RS00710	COG4172	Belongs to the ABC transporter superfamily
I6K98_RS00715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K98_RS00720	COG0601	transmembrane transport
I6K98_RS00725	COG0747	negative chemotaxis
I6K98_RS00735	COG0598	Magnesium transport protein CorA
I6K98_RS00740	COG0210	DNA helicase
I6K98_RS00755	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K98_RS00760	COG1012	belongs to the aldehyde dehydrogenase family
I6K98_RS00765	COG0483	inositol monophosphate 1-phosphatase activity
I6K98_RS00770	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6K98_RS00780	COG1045	serine acetyltransferase
I6K98_RS00785	COG0166	Belongs to the GPI family
I6K98_RS00815	COG3181	Tripartite tricarboxylate transporter family receptor
I6K98_RS00830	COG1017	nitric oxide dioxygenase activity
I6K98_RS00830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K98_RS00845	COG1335	isochorismatase
I6K98_RS00850	COG2309	aminopeptidase activity
I6K98_RS00860	COG3473	Maleate cis-trans isomerase
I6K98_RS00865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K98_RS00870	COG2080	2 iron, 2 sulfur cluster binding
I6K98_RS00905	COG1846	Transcriptional regulator
I6K98_RS00925	COG1649	PFAM Uncharacterised BCR, COG1649
I6K98_RS00925	COG0726	polysaccharide deacetylase
I6K98_RS00930	COG1215	transferase activity, transferring glycosyl groups
I6K98_RS00940	COG1902	pentaerythritol trinitrate reductase activity
I6K98_RS00965	COG0251	oxidation-reduction process
I6K98_RS00975	COG1832	CoA-binding protein
I6K98_RS00980	COG1414	Transcriptional regulator
I6K98_RS00985	COG1902	pentaerythritol trinitrate reductase activity
I6K98_RS00985	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6K98_RS00995	COG3842	ATPase activity
I6K98_RS01020	COG0583	DNA-binding transcription factor activity
I6K98_RS01030	COG1028	Short-chain dehydrogenase reductase Sdr
I6K98_RS01035	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
I6K98_RS01040	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6K98_RS01055	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6K98_RS01055	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6K98_RS01060	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K98_RS01085	COG0527	aspartate kinase activity
I6K98_RS01090	COG0037	tRNA processing
I6K98_RS01100	COG0825	malonyl-CoA metabolic process
I6K98_RS01110	COG0215	cysteine-tRNA ligase activity
I6K98_RS01125	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6K98_RS01130	COG1968	undecaprenyl-diphosphatase activity
I6K98_RS01135	COG1253	flavin adenine dinucleotide binding
I6K98_RS01140	COG0483	inositol monophosphate 1-phosphatase activity
I6K98_RS01160	COG0668	transmembrane transport
I6K98_RS01210	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6K98_RS01225	COG2831	hemolysin activation secretion protein
I6K98_RS01230	COG3539	Fimbrial protein
I6K98_RS01235	COG3188	usher protein
I6K98_RS01240	COG3121	Chaperone
I6K98_RS01250	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
I6K98_RS01250	COG3210	domain, Protein
I6K98_RS01250	COG3064	Membrane
I6K98_RS01255	COG2197	response regulator
I6K98_RS01260	COG2205	protein histidine kinase activity
I6K98_RS01260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K98_RS01270	COG4336	lyase activity
I6K98_RS01315	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6K98_RS01325	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6K98_RS01325	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6K98_RS01335	COG0028	Belongs to the TPP enzyme family
I6K98_RS01350	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K98_RS01360	COG1126	abc transporter atp-binding protein
I6K98_RS01370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K98_RS01385	COG0084	hydrolase, TatD family'
I6K98_RS01390	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6K98_RS01395	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6K98_RS01400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6K98_RS01425	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6K98_RS01430	COG0336	Belongs to the RNA methyltransferase TrmD family
I6K98_RS01435	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6K98_RS01440	COG0228	four-way junction DNA binding
I6K98_RS01450	COG0425	Belongs to the sulfur carrier protein TusA family
I6K98_RS01455	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6K98_RS01500	COG0154	amidase activity
I6K98_RS01505	COG4172	Belongs to the ABC transporter superfamily
I6K98_RS01510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K98_RS01515	COG0601	transmembrane transport
I6K98_RS01520	COG0747	negative chemotaxis
I6K98_RS01550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K98_RS01560	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6K98_RS01580	COG3395	kinase activity
I6K98_RS01600	COG1024	Enoyl-CoA hydratase
I6K98_RS01620	COG0633	Ferredoxin
I6K98_RS01625	COG0443	Heat shock 70 kDa protein
I6K98_RS01630	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6K98_RS01635	COG0316	Belongs to the HesB IscA family
I6K98_RS01640	COG0822	iron-sulfur transferase activity
I6K98_RS01645	COG1104	cysteine desulfurase activity
I6K98_RS01655	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6K98_RS01660	COG0556	nucleotide-excision repair
I6K98_RS01670	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K98_RS01700	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K98_RS01720	COG1028	Short-chain dehydrogenase reductase Sdr
I6K98_RS01725	COG0183	Belongs to the thiolase family
I6K98_RS01735	COG1024	Enoyl-CoA hydratase
I6K98_RS01750	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K98_RS01755	COG0583	DNA-binding transcription factor activity
I6K98_RS01760	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6K98_RS01765	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6K98_RS01770	COG0740	serine-type endopeptidase activity
I6K98_RS01775	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6K98_RS01785	COG1278	Cold shock
I6K98_RS01795	COG1278	Cold shock
I6K98_RS01830	COG2171	N-acyltransferase activity
I6K98_RS01835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K98_RS01840	COG2890	protein-(glutamine-N5) methyltransferase activity
I6K98_RS01845	COG0488	(ABC) transporter
I6K98_RS01850	COG4771	TonB-dependent receptor
I6K98_RS01855	COG0210	DNA helicase
I6K98_RS01880	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6K98_RS01885	COG0196	riboflavin kinase activity
I6K98_RS01890	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6K98_RS01895	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6K98_RS01900	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6K98_RS01910	COG1522	sequence-specific DNA binding
I6K98_RS01925	COG2951	lytic endotransglycosylase activity
I6K98_RS01930	COG2833	Protein of unknown function (DUF455)
I6K98_RS01950	COG0189	ligase activity
I6K98_RS01950	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K98_RS01955	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K98_RS01955	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6K98_RS01960	COG3237	CsbD-like
I6K98_RS01970	COG2823	Periplasmic or secreted lipoprotein
I6K98_RS01990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K98_RS01995	COG0584	glycerophosphoryl diester phosphodiesterase
I6K98_RS02000	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6K98_RS02010	COG0678	peroxiredoxin activity
I6K98_RS02010	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K98_RS02020	COG0789	Transcriptional regulator
I6K98_RS02025	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6K98_RS02055	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6K98_RS02060	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6K98_RS02070	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6K98_RS02075	COG2252	PERMEase
I6K98_RS02085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K98_RS02120	COG0488	(ABC) transporter
I6K98_RS02125	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6K98_RS02140	COG1024	Enoyl-CoA hydratase
I6K98_RS02145	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6K98_RS02150	COG0590	tRNA wobble adenosine to inosine editing
I6K98_RS02175	COG2212	antiporter activity
I6K98_RS02180	COG1863	multisubunit Na H antiporter MnhE subunit
I6K98_RS02185	COG0651	ATP synthesis coupled electron transport
I6K98_RS02190	COG1006	Multisubunit Na H antiporter MnhC subunit
I6K98_RS02195	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6K98_RS02195	COG2111	Na H antiporter
I6K98_RS02215	COG0583	DNA-binding transcription factor activity
I6K98_RS02220	COG1028	Short-chain dehydrogenase reductase Sdr
I6K98_RS02250	COG0431	NADPH-dependent FMN reductase
I6K98_RS02295	COG1028	Short-chain dehydrogenase reductase Sdr
I6K98_RS02300	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K98_RS02330	COG0625	glutathione transferase activity
I6K98_RS02340	COG2944	sequence-specific DNA binding
I6K98_RS02350	COG2197	response regulator
I6K98_RS02370	COG0300	oxidoreductase activity
I6K98_RS02415	COG0861	Integral membrane protein TerC family
I6K98_RS02420	COG1028	Short-chain dehydrogenase reductase Sdr
I6K98_RS02440	COG0714	Associated with various cellular activities
I6K98_RS02475	COG3119	arylsulfatase activity
I6K98_RS02505	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6K98_RS02520	COG0438	transferase activity, transferring glycosyl groups
I6K98_RS02545	COG0463	Glycosyl transferase, family 2
I6K98_RS02560	COG0783	Belongs to the Dps family
I6K98_RS02575	COG0583	DNA-binding transcription factor activity
I6K98_RS02580	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6K98_RS02595	COG0656	L-ascorbic acid biosynthetic process
I6K98_RS02605	COG0583	DNA-binding transcription factor activity
I6K98_RS02615	COG1840	ABC-type Fe3 transport system, periplasmic component
I6K98_RS02620	COG1178	ABC-type Fe3 transport system permease component
I6K98_RS02625	COG3842	ATPase activity
I6K98_RS02635	COG1741	Belongs to the pirin family
I6K98_RS02640	COG1741	Belongs to the pirin family
I6K98_RS02645	COG0583	DNA-binding transcription factor activity
I6K98_RS02650	COG2204	response regulator
I6K98_RS02660	COG0174	glutamine synthetase
I6K98_RS02665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K98_RS02675	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6K98_RS02680	COG2200	EAL domain
I6K98_RS02680	COG2199	diguanylate cyclase activity
I6K98_RS02700	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6K98_RS02705	COG1561	YicC-like family, N-terminal region
I6K98_RS02720	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6K98_RS02725	COG0791	NLP P60 protein
I6K98_RS02730	COG1028	Short-chain dehydrogenase reductase Sdr
I6K98_RS02735	COG2863	cytochrome
I6K98_RS02740	COG3258	Cytochrome c
I6K98_RS02745	COG0194	GDP metabolic process
I6K98_RS02750	COG1758	RNA polymerase activity
I6K98_RS02755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K98_RS02760	COG1126	abc transporter atp-binding protein
I6K98_RS02765	COG0765	amino acid transport
I6K98_RS02770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K98_RS02785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K98_RS02790	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6K98_RS02795	COG3539	Fimbrial protein
I6K98_RS02800	COG2850	peptidyl-arginine hydroxylation
I6K98_RS02805	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6K98_RS02810	COG3360	Dodecin
I6K98_RS02850	COG0009	L-threonylcarbamoyladenylate synthase
I6K98_RS02855	COG2321	neutral zinc metallopeptidase
I6K98_RS02875	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6K98_RS02880	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6K98_RS02885	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6K98_RS02895	COG1074	ATP-dependent DNA helicase activity
I6K98_RS02910	COG2814	Major facilitator Superfamily
I6K98_RS02920	COG1686	Belongs to the peptidase S11 family
I6K98_RS02935	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I6K98_RS02940	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K98_RS02945	COG4974	Belongs to the 'phage' integrase family
I6K98_RS02950	COG0583	DNA-binding transcription factor activity
I6K98_RS02955	COG0028	Belongs to the TPP enzyme family
I6K98_RS02970	COG0028	Belongs to the TPP enzyme family
I6K98_RS02975	COG1126	abc transporter atp-binding protein
I6K98_RS02980	COG0765	amino acid transport
I6K98_RS02995	COG1414	Transcriptional regulator
I6K98_RS03000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K98_RS03005	COG0009	L-threonylcarbamoyladenylate synthase
I6K98_RS03010	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6K98_RS03015	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6K98_RS03020	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6K98_RS03030	COG2944	sequence-specific DNA binding
I6K98_RS03040	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6K98_RS03095	COG1126	abc transporter atp-binding protein
I6K98_RS03100	COG0765	amino acid transport
I6K98_RS03105	COG0765	amino acid transport
I6K98_RS03110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K98_RS03120	COG2423	ornithine cyclodeaminase activity
I6K98_RS03135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K98_RS03140	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K98_RS03150	COG0189	ligase activity
I6K98_RS03155	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6K98_RS03160	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6K98_RS03165	COG2197	response regulator
I6K98_RS03200	COG0135	phosphoribosylanthranilate isomerase activity
I6K98_RS03215	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6K98_RS03220	COG0101	tRNA pseudouridine synthase activity
I6K98_RS03230	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K98_RS03235	COG0473	3-isopropylmalate dehydrogenase activity
I6K98_RS03240	COG0066	3-isopropylmalate dehydratase activity
I6K98_RS03245	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6K98_RS03255	COG1122	ATPase activity
I6K98_RS03290	COG3383	formate dehydrogenase (NAD+) activity
I6K98_RS03290	COG0243	molybdopterin cofactor binding
I6K98_RS03320	COG0489	protein tyrosine kinase activity
I6K98_RS03325	COG0746	molybdenum cofactor guanylyltransferase activity
I6K98_RS03330	COG0303	'Molybdopterin
I6K98_RS03335	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6K98_RS03345	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6K98_RS03350	COG5001	Diguanylate cyclase
I6K98_RS03370	COG3842	ATPase activity
I6K98_RS03380	COG0406	alpha-ribazole phosphatase activity
I6K98_RS03390	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6K98_RS03395	COG0505	Belongs to the CarA family
I6K98_RS03400	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K98_RS03430	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6K98_RS03435	COG1960	acyl-CoA dehydrogenase activity
I6K98_RS03445	COG2867	negative regulation of translational initiation
I6K98_RS03450	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6K98_RS03455	COG3706	GGDEF domain
I6K98_RS03460	COG0330	HflC and HflK could
I6K98_RS03475	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6K98_RS03475	COG0519	Catalyzes the synthesis of GMP from XMP
I6K98_RS03485	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6K98_RS03490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K98_RS03495	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6K98_RS03500	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6K98_RS03510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6K98_RS03515	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6K98_RS03520	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6K98_RS03525	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K98_RS03530	COG0750	zinc metalloprotease
I6K98_RS03535	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6K98_RS03545	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6K98_RS03550	COG0233	cytoplasmic translational termination
I6K98_RS03555	COG0528	UMP kinase activity
I6K98_RS03560	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6K98_RS03565	COG0052	Belongs to the universal ribosomal protein uS2 family
I6K98_RS03570	COG0024	Methionine aminopeptidase
I6K98_RS03575	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6K98_RS03605	COG0285	dihydrofolate synthase activity
I6K98_RS03640	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6K98_RS03650	COG1677	Flagellar hook-basal body complex protein FliE
I6K98_RS03660	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6K98_RS03670	COG1157	protein secretion by the type III secretion system
I6K98_RS03695	COG1580	Controls the rotational direction of flagella during chemotaxis
I6K98_RS03715	COG1338	Plays a role in the flagellum-specific transport system
I6K98_RS03735	COG0840	transmembrane signaling receptor activity
I6K98_RS03740	COG0840	transmembrane signaling receptor activity
I6K98_RS03745	COG0840	transmembrane signaling receptor activity
I6K98_RS03755	COG1256	bacterial-type flagellum assembly
I6K98_RS03765	COG1706	bacterial-type flagellum-dependent cell motility
I6K98_RS03770	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6K98_RS03785	COG1749	Flagellar hook protein flgE
I6K98_RS03795	COG1558	bacterial-type flagellum-dependent cell motility
I6K98_RS03800	COG1815	bacterial-type flagellum-dependent cell motility
I6K98_RS03840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K98_RS03845	COG0765	amino acid transport
I6K98_RS03850	COG1126	abc transporter atp-binding protein
I6K98_RS03865	COG4948	Mandelate Racemase Muconate Lactonizing
I6K98_RS03870	COG3181	Tripartite tricarboxylate transporter family receptor
I6K98_RS03880	COG0066	3-isopropylmalate dehydratase activity
I6K98_RS03895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K98_RS03905	COG3181	Tripartite tricarboxylate transporter family receptor
I6K98_RS03915	COG1802	Transcriptional regulator
I6K98_RS03930	COG0583	DNA-binding transcription factor activity
I6K98_RS03950	COG1695	Transcriptional regulator
I6K98_RS03960	COG3568	Endonuclease Exonuclease Phosphatase
I6K98_RS03965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K98_RS04015	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6K98_RS04025	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6K98_RS04045	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6K98_RS04075	COG0667	Aldo Keto reductase
I6K98_RS04090	COG2259	Doxx family
I6K98_RS04120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K98_RS04140	COG0386	Belongs to the glutathione peroxidase family
I6K98_RS04145	COG0625	glutathione transferase activity
I6K98_RS04160	COG0095	Lipoate-protein ligase
I6K98_RS04175	COG0688	phosphatidylethanolamine metabolic process
I6K98_RS04185	COG1464	Belongs to the NlpA lipoprotein family
I6K98_RS04200	COG2363	Small membrane protein
I6K98_RS04235	COG3842	ATPase activity
I6K98_RS04240	COG0395	ABC-type sugar transport system, permease component
I6K98_RS04245	COG1175	transmembrane transport
I6K98_RS04250	COG1653	transport
I6K98_RS04260	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6K98_RS04275	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6K98_RS04295	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6K98_RS04320	COG2311	Membrane
I6K98_RS04345	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6K98_RS04355	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6K98_RS04360	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6K98_RS04365	COG1760	l-serine dehydratase
I6K98_RS04370	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6K98_RS04375	COG0412	Dienelactone hydrolase
I6K98_RS04390	COG1611	Belongs to the LOG family
I6K98_RS04410	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6K98_RS04415	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6K98_RS04420	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6K98_RS04425	COG0195	Participates in both transcription termination and antitermination
I6K98_RS04425	COG2251	uridine kinase activity
I6K98_RS04430	COG0779	Required for maturation of 30S ribosomal subunits
I6K98_RS04435	COG1187	pseudouridine synthase activity
I6K98_RS04440	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6K98_RS04450	COG0583	DNA-binding transcription factor activity
I6K98_RS04460	COG0523	cobalamin synthesis protein
I6K98_RS04480	COG0625	glutathione transferase activity
I6K98_RS04485	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6K98_RS04490	COG1047	Peptidyl-prolyl cis-trans
I6K98_RS04495	COG2003	Belongs to the UPF0758 family
I6K98_RS04500	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
I6K98_RS04505	COG3483	tryptophan 2,3-dioxygenase activity
I6K98_RS04510	COG0254	rRNA binding
I6K98_RS04520	COG0534	Mate efflux family protein
I6K98_RS04540	COG2304	oxidoreductase activity
I6K98_RS04560	COG1028	Short-chain dehydrogenase reductase Sdr
I6K98_RS04565	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6K98_RS04570	COG1562	ergosterol biosynthetic process
I6K98_RS04575	COG1562	ergosterol biosynthetic process
I6K98_RS04580	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I6K98_RS04580	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I6K98_RS04585	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6K98_RS04595	COG0842	Transport permease protein
I6K98_RS04600	COG1131	(ABC) transporter
I6K98_RS04620	COG1477	protein flavinylation
I6K98_RS04635	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6K98_RS04650	COG5564	TIM-barrel signal transduction protein
I6K98_RS04655	COG5441	Belongs to the UPF0261 family
I6K98_RS04665	COG3468	outer membrane autotransporter barrel domain protein
I6K98_RS04685	COG0542	response to heat
I6K98_RS04690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K98_RS04705	COG0494	nUDIX hydrolase
I6K98_RS04710	COG3530	Putative quorum-sensing-regulated virulence factor
I6K98_RS04720	COG1595	DNA-templated transcription, initiation
I6K98_RS04725	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K98_RS04760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K98_RS04765	COG0765	amino acid transport
I6K98_RS04770	COG0765	amino acid transport
I6K98_RS04800	COG2988	succinylglutamate desuccinylase activity
I6K98_RS04825	COG3181	Tripartite tricarboxylate transporter family receptor
I6K98_RS04830	COG2084	Dehydrogenase
I6K98_RS04845	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6K98_RS04855	COG2814	Major facilitator Superfamily
I6K98_RS04865	COG0583	DNA-binding transcription factor activity
I6K98_RS04905	COG0672	)-iron permease
I6K98_RS04920	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
I6K98_RS04925	COG1028	Short-chain dehydrogenase reductase Sdr
I6K98_RS04930	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6K98_RS04940	COG0564	pseudouridine synthase activity
I6K98_RS04950	COG1199	ATP-dependent helicase activity
I6K98_RS04955	COG2183	response to ionizing radiation
I6K98_RS04960	COG0180	Tryptophanyl-tRNA synthetase
I6K98_RS04985	COG4774	siderophore transport
I6K98_RS04990	COG3712	iron ion homeostasis
I6K98_RS04995	COG1595	DNA-templated transcription, initiation
I6K98_RS05020	COG3181	Tripartite tricarboxylate transporter family receptor
I6K98_RS05030	COG0583	DNA-binding transcription factor activity
I6K98_RS05035	COG1028	Short-chain dehydrogenase reductase Sdr
I6K98_RS05040	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6K98_RS05045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K98_RS05050	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K98_RS05055	COG0567	Dehydrogenase, E1 component
I6K98_RS05060	COG1297	OPT oligopeptide transporter protein
I6K98_RS05065	COG1522	sequence-specific DNA binding
I6K98_RS05075	COG0281	malic enzyme
I6K98_RS05075	COG0280	phosphate acetyltransferase
I6K98_RS05080	COG3539	Fimbrial protein
I6K98_RS05095	COG0613	PHP domain protein
I6K98_RS05105	COG0658	competence protein
I6K98_RS05105	COG2333	competence protein COMEC
I6K98_RS05130	COG0084	hydrolase, TatD family'
I6K98_RS05135	COG1136	(ABC) transporter
I6K98_RS05150	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6K98_RS05160	COG1028	Short-chain dehydrogenase reductase Sdr
I6K98_RS05165	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6K98_RS05180	COG1022	Amp-dependent synthetase and ligase
I6K98_RS05215	COG2205	protein histidine kinase activity
I6K98_RS05220	COG0745	RESPONSE REGULATOR receiver
I6K98_RS05225	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6K98_RS05235	COG1295	ribonuclease BN
I6K98_RS05250	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K98_RS05280	COG1534	Rna-binding protein
I6K98_RS05285	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6K98_RS05295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6K98_RS05305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6K98_RS05315	COG0248	Ppx GppA phosphatase
I6K98_RS05340	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6K98_RS05355	COG2732	(Barnase) inhibitor
I6K98_RS05375	COG0436	Aminotransferase
I6K98_RS05380	COG0741	lytic transglycosylase activity
I6K98_RS05385	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K98_RS05410	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6K98_RS05410	COG1648	precorrin-2 dehydrogenase activity
I6K98_RS05415	COG3468	outer membrane autotransporter barrel domain protein
I6K98_RS05425	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6K98_RS05430	COG2027	D-alanyl-D-alanine carboxypeptidase
I6K98_RS05435	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6K98_RS05440	COG0343	queuine tRNA-ribosyltransferase activity
I6K98_RS05450	COG1862	Preprotein translocase
I6K98_RS05455	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K98_RS05460	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K98_RS05475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6K98_RS05480	COG1702	phosphate starvation-inducible protein PhoH
I6K98_RS05485	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6K98_RS05490	COG4535	Mg2 and Co2 transporter CorC
I6K98_RS05500	COG0667	Aldo Keto reductase
I6K98_RS05525	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6K98_RS05530	COG0745	RESPONSE REGULATOR receiver
I6K98_RS05535	COG2201	protein-glutamate methylesterase activity
I6K98_RS05545	COG0840	transmembrane signaling receptor activity
I6K98_RS05560	COG0745	RESPONSE REGULATOR receiver
I6K98_RS05595	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6K98_RS05605	COG0739	heme binding
I6K98_RS05615	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K98_RS05620	COG0306	phosphate transporter
I6K98_RS05625	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6K98_RS05665	COG0625	glutathione transferase activity
I6K98_RS05680	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6K98_RS05685	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6K98_RS05690	COG0126	phosphoglycerate kinase activity
I6K98_RS05695	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6K98_RS05700	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K98_RS05705	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6K98_RS05715	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6K98_RS05720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K98_RS05725	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K98_RS05730	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6K98_RS05740	COG4566	intracellular signal transduction
I6K98_RS05745	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6K98_RS05750	COG0339	signal peptide processing
I6K98_RS05755	COG1999	signal sequence binding
I6K98_RS05785	COG1187	pseudouridine synthase activity
I6K98_RS05790	COG3161	chorismate lyase activity
I6K98_RS05805	COG0667	Aldo Keto reductase
I6K98_RS05815	COG0335	large ribosomal subunit rRNA binding
I6K98_RS05850	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6K98_RS05870	COG0450	alkyl hydroperoxide reductase
I6K98_RS05875	COG1960	acyl-CoA dehydrogenase activity
I6K98_RS05890	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6K98_RS05895	COG2951	lytic endotransglycosylase activity
I6K98_RS05910	COG1555	photosystem II stabilization
I6K98_RS05910	COG1596	polysaccharide export
I6K98_RS05915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K98_RS05920	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6K98_RS05925	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6K98_RS05945	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6K98_RS05950	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6K98_RS05955	COG0287	Prephenate dehydrogenase
I6K98_RS05965	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6K98_RS05980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6K98_RS05990	COG2814	Major facilitator Superfamily
I6K98_RS06015	COG0583	DNA-binding transcription factor activity
I6K98_RS06055	COG0583	DNA-binding transcription factor activity
I6K98_RS06070	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K98_RS06095	COG1053	succinate dehydrogenase
I6K98_RS06100	COG1012	belongs to the aldehyde dehydrogenase family
I6K98_RS06105	COG2079	MmgE PrpD family protein
I6K98_RS06115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K98_RS06165	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6K98_RS06180	COG0667	Aldo Keto reductase
I6K98_RS06190	COG5265	(ABC) transporter
I6K98_RS06235	COG0439	Biotin carboxylase
I6K98_RS06240	COG2188	Transcriptional regulator
I6K98_RS06265	COG0511	ligase activity, forming carbon-carbon bonds
I6K98_RS06295	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I6K98_RS06315	COG0500	methyltransferase
I6K98_RS06320	COG5265	(ABC) transporter
I6K98_RS06335	COG0308	aminopeptidase N
I6K98_RS06340	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6K98_RS06350	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6K98_RS06355	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6K98_RS06360	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6K98_RS06365	COG0560	Phosphoserine phosphatase
I6K98_RS06370	COG0583	DNA-binding transcription factor activity
I6K98_RS06375	COG3181	Tripartite tricarboxylate transporter family receptor
I6K98_RS06380	COG0028	Belongs to the TPP enzyme family
I6K98_RS06395	COG4774	siderophore transport
I6K98_RS06400	COG4774	siderophore transport
I6K98_RS06410	COG1007	ATP synthesis coupled electron transport
I6K98_RS06425	COG0713	ATP synthesis coupled electron transport
I6K98_RS06435	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K98_RS06440	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6K98_RS06445	COG1034	ATP synthesis coupled electron transport
I6K98_RS06455	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
I6K98_RS06460	COG0649	NAD binding
I6K98_RS06465	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K98_RS06470	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K98_RS06475	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K98_RS06480	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K98_RS06505	COG0671	phosphoesterase, PA-phosphatase related
I6K98_RS06520	COG0583	DNA-binding transcription factor activity
I6K98_RS06525	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K98_RS06535	COG1733	regulation of RNA biosynthetic process
I6K98_RS06540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K98_RS06545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K98_RS06560	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
I6K98_RS06580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K98_RS06600	COG3608	succinylglutamate desuccinylase aspartoacylase
I6K98_RS06605	COG0626	cystathionine gamma-synthase activity
I6K98_RS06610	COG0583	DNA-binding transcription factor activity
I6K98_RS06645	COG3799	methylaspartate ammonia-lyase activity
I6K98_RS06655	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K98_RS06665	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6K98_RS06670	COG0149	triose-phosphate isomerase activity
I6K98_RS06690	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K98_RS06705	COG1185	polyribonucleotide nucleotidyltransferase activity
I6K98_RS06710	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6K98_RS06720	COG1183	phosphatidylcholine synthase activity
I6K98_RS06725	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6K98_RS06730	COG0440	acetolactate synthase activity
I6K98_RS06735	COG0028	Belongs to the TPP enzyme family
I6K98_RS06755	COG0028	Belongs to the TPP enzyme family
I6K98_RS06775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K98_RS06785	COG0318	PFAM AMP-dependent synthetase and ligase
I6K98_RS06795	COG1802	Transcriptional regulator
I6K98_RS06805	COG1802	Transcriptional regulator
I6K98_RS06815	COG1028	Short-chain dehydrogenase reductase Sdr
I6K98_RS06835	COG1126	abc transporter atp-binding protein
I6K98_RS06840	COG0765	amino acid transport
I6K98_RS06860	COG1538	Outer membrane efflux protein
I6K98_RS06865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K98_RS06870	COG2274	protein secretion by the type I secretion system
I6K98_RS06875	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I6K98_RS06885	COG2994	toxin metabolic process
I6K98_RS06910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K98_RS06915	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
I6K98_RS06925	COG0583	DNA-binding transcription factor activity
I6K98_RS06935	COG0142	geranyltranstransferase activity
I6K98_RS06945	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6K98_RS06950	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6K98_RS06955	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6K98_RS06960	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6K98_RS07000	COG3712	iron ion homeostasis
I6K98_RS07005	COG4774	siderophore transport
I6K98_RS07010	COG2353	YceI-like domain
I6K98_RS07025	COG0019	diaminopimelate decarboxylase activity
I6K98_RS07045	COG0747	negative chemotaxis
I6K98_RS07050	COG0601	transmembrane transport
I6K98_RS07055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K98_RS07065	COG0154	amidase activity
I6K98_RS07070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K98_RS07105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K98_RS07110	COG3568	Endonuclease Exonuclease Phosphatase
I6K98_RS07115	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6K98_RS07150	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6K98_RS07160	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6K98_RS07175	COG1137	ATPase activity
I6K98_RS07190	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I6K98_RS07195	COG2010	Cytochrome c
I6K98_RS07195	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6K98_RS07205	COG1660	Displays ATPase and GTPase activities
I6K98_RS07210	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K98_RS07245	COG3181	Tripartite tricarboxylate transporter family receptor
I6K98_RS07255	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6K98_RS07260	COG2890	protein-(glutamine-N5) methyltransferase activity
I6K98_RS07265	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6K98_RS07270	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6K98_RS07315	COG1960	acyl-CoA dehydrogenase activity
I6K98_RS07325	COG0183	Belongs to the thiolase family
I6K98_RS07330	COG1522	sequence-specific DNA binding
I6K98_RS07335	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6K98_RS07355	COG1024	Enoyl-CoA hydratase
I6K98_RS07370	COG0604	alcohol dehydrogenase
I6K98_RS07375	COG2072	flavoprotein involved in K transport
I6K98_RS07390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K98_RS07400	COG1960	acyl-CoA dehydrogenase activity
I6K98_RS07405	COG1960	acyl-CoA dehydrogenase activity
I6K98_RS07410	COG0277	FAD linked oxidase domain protein
I6K98_RS07420	COG3181	Tripartite tricarboxylate transporter family receptor
I6K98_RS07450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K98_RS07460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K98_RS07465	COG3181	Tripartite tricarboxylate transporter family receptor
I6K98_RS07470	COG1960	acyl-CoA dehydrogenase activity
I6K98_RS07490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6K98_RS07495	COG1024	Enoyl-CoA hydratase
I6K98_RS07500	COG1960	acyl-CoA dehydrogenase activity
I6K98_RS07520	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6K98_RS07525	COG0022	dehydrogenase e1 component
I6K98_RS07530	COG1024	Enoyl-CoA hydratase
I6K98_RS07535	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K98_RS07555	COG0683	leucine binding
I6K98_RS07560	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6K98_RS07565	COG0411	ABC transporter
I6K98_RS07575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K98_RS07590	COG3181	Tripartite tricarboxylate transporter family receptor
I6K98_RS07615	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K98_RS07620	COG0793	Belongs to the peptidase S41A family
I6K98_RS07625	COG4942	peptidase
I6K98_RS07630	COG0588	phosphoglycerate mutase activity
I6K98_RS07635	COG1054	Belongs to the UPF0176 family
I6K98_RS07640	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K98_RS07645	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6K98_RS07650	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6K98_RS07655	COG3181	Tripartite tricarboxylate transporter family receptor
I6K98_RS07670	COG2226	methyltransferase
I6K98_RS07675	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6K98_RS07690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K98_RS07695	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6K98_RS07720	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6K98_RS07745	COG1335	isochorismatase
I6K98_RS07750	COG2309	aminopeptidase activity
I6K98_RS07760	COG3473	Maleate cis-trans isomerase
I6K98_RS07770	COG2068	MobA-Related Protein
I6K98_RS07795	COG2204	response regulator
I6K98_RS07800	COG5000	phosphorelay sensor kinase activity
I6K98_RS07810	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6K98_RS07810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6K98_RS07820	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
I6K98_RS07840	COG0583	DNA-binding transcription factor activity
I6K98_RS07860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K98_RS07865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K98_RS07880	COG0758	DNA mediated transformation
I6K98_RS07885	COG1522	sequence-specific DNA binding
I6K98_RS07895	COG0242	peptide deformylase activity
I6K98_RS07900	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6K98_RS07910	COG0546	phosphoglycolate phosphatase activity
I6K98_RS07930	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6K98_RS07935	COG1942	4-Oxalocrotonate Tautomerase
I6K98_RS07940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K98_RS07960	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K98_RS07980	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K98_RS07985	COG1024	Enoyl-CoA hydratase
I6K98_RS07990	COG1414	Transcriptional regulator
I6K98_RS07995	COG0318	PFAM AMP-dependent synthetase and ligase
I6K98_RS08000	COG3181	Tripartite tricarboxylate transporter family receptor
I6K98_RS08040	COG3422	double-strand break repair
I6K98_RS08045	COG0330	HflC and HflK could
I6K98_RS08055	COG0251	oxidation-reduction process
I6K98_RS08100	COG3723	Recombinational DNA repair protein, rece pathway
I6K98_RS08130	COG0582	viral genome integration into host DNA
I6K98_RS08165	COG0706	membrane insertase activity
I6K98_RS08170	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6K98_RS08175	COG0594	ribonuclease P activity
I6K98_RS08180	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6K98_RS08185	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6K98_RS08200	COG1414	Transcriptional regulator
I6K98_RS08205	COG0154	amidase activity
I6K98_RS08220	COG1304	FMN binding
I6K98_RS08240	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6K98_RS08245	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6K98_RS08250	COG0546	phosphoglycolate phosphatase activity
I6K98_RS08260	COG1530	ribonuclease E activity
I6K98_RS08280	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6K98_RS08290	COG3781	membrane
I6K98_RS08295	COG1522	sequence-specific DNA binding
I6K98_RS08300	COG0028	Belongs to the TPP enzyme family
I6K98_RS08310	COG1012	belongs to the aldehyde dehydrogenase family
I6K98_RS08315	COG1028	Short-chain dehydrogenase reductase Sdr
I6K98_RS08320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K98_RS08325	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6K98_RS08350	COG2922	Belongs to the Smg family
I6K98_RS08355	COG1629	transport
I6K98_RS08365	COG2358	TRAP transporter, solute receptor (TAXI family
I6K98_RS08375	COG3181	Tripartite tricarboxylate transporter family receptor
I6K98_RS08380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K98_RS08395	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6K98_RS08400	COG0183	Belongs to the thiolase family
I6K98_RS08445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K98_RS08450	COG0583	DNA-binding transcription factor activity
I6K98_RS08460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K98_RS08480	COG0251	oxidation-reduction process
I6K98_RS08485	COG1017	nitric oxide dioxygenase activity
I6K98_RS08485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K98_RS08490	COG2031	fatty acid transporter
I6K98_RS08495	COG1012	belongs to the aldehyde dehydrogenase family
I6K98_RS08500	COG1802	Transcriptional regulator
I6K98_RS08510	COG1278	Cold shock
I6K98_RS08515	COG0583	DNA-binding transcription factor activity
I6K98_RS08530	COG0183	Belongs to the thiolase family
I6K98_RS08540	COG1960	acyl-CoA dehydrogenase activity
I6K98_RS08545	COG0583	DNA-binding transcription factor activity
I6K98_RS08550	COG3181	Tripartite tricarboxylate transporter family receptor
I6K98_RS08555	COG1024	Enoyl-CoA hydratase
I6K98_RS08560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K98_RS08565	COG1253	flavin adenine dinucleotide binding
I6K98_RS08570	COG1285	pathogenesis
I6K98_RS08580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K98_RS08595	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6K98_RS08610	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K98_RS08625	COG2031	fatty acid transporter
I6K98_RS08635	COG0786	glutamate:sodium symporter activity
I6K98_RS08650	COG0463	Glycosyl transferase, family 2
I6K98_RS08655	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6K98_RS08685	COG0697	spore germination
I6K98_RS08695	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K98_RS08710	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6K98_RS08715	COG2823	Periplasmic or secreted lipoprotein
I6K98_RS08730	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6K98_RS08740	COG1309	transcriptional regulator
I6K98_RS08745	COG0471	metal ion transport
I6K98_RS08750	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6K98_RS08755	COG0772	Belongs to the SEDS family
I6K98_RS08760	COG0768	penicillin binding
I6K98_RS08770	COG1792	Involved in formation and maintenance of cell shape
I6K98_RS08775	COG1077	Cell shape determining protein MreB Mrl
I6K98_RS08780	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6K98_RS08785	COG0154	amidase activity
I6K98_RS08790	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6K98_RS08795	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6K98_RS08800	COG0708	Exodeoxyribonuclease III
I6K98_RS08805	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K98_RS08810	COG2860	membrane
I6K98_RS08845	COG1012	belongs to the aldehyde dehydrogenase family
I6K98_RS08855	COG3069	C4-dicarboxylate transmembrane transporter activity
I6K98_RS08865	COG1802	Transcriptional regulator
I6K98_RS08900	COG1595	DNA-templated transcription, initiation
I6K98_RS08905	COG3712	iron ion homeostasis
I6K98_RS08915	COG3720	iron ion transport
I6K98_RS08920	COG4558	Periplasmic binding protein
I6K98_RS08925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K98_RS08930	COG1120	ATPase activity
I6K98_RS08935	COG1683	Conserved Protein
I6K98_RS08965	COG3064	Membrane
I6K98_RS08985	COG1234	tRNA 3'-trailer cleavage
I6K98_RS09020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K98_RS09030	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6K98_RS09045	COG0540	Belongs to the ATCase OTCase family
I6K98_RS09050	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6K98_RS09055	COG1678	Uncharacterized ACR, COG1678
I6K98_RS09070	COG0352	thiamine-phosphate diphosphorylase activity
I6K98_RS09075	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6K98_RS09100	COG1960	acyl-CoA dehydrogenase activity
I6K98_RS09105	COG1024	Enoyl-CoA hydratase
I6K98_RS09175	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
I6K98_RS09185	COG0583	DNA-binding transcription factor activity
I6K98_RS09190	COG2814	Major facilitator Superfamily
I6K98_RS09195	COG0129	dihydroxy-acid dehydratase activity
I6K98_RS09200	COG2207	Transcriptional regulator
I6K98_RS09205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6K98_RS09215	COG0657	acetylesterase activity
I6K98_RS09220	COG0747	negative chemotaxis
I6K98_RS09225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K98_RS09230	COG2808	Putative FMN-binding domain
I6K98_RS09245	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6K98_RS09250	COG1970	mechanosensitive ion channel activity
I6K98_RS09255	COG0723	plastoquinol--plastocyanin reductase activity
I6K98_RS09260	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6K98_RS09265	COG2857	Cytochrome c1
I6K98_RS09270	COG0625	glutathione transferase activity
I6K98_RS09275	COG2969	positive regulation of protein catabolic process
I6K98_RS09315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6K98_RS09320	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6K98_RS09325	COG4988	ABC transporter
I6K98_RS09335	COG1294	oxidase, subunit
I6K98_RS09370	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K98_RS09375	COG0405	Gamma-glutamyltransferase
I6K98_RS09385	COG3181	Tripartite tricarboxylate transporter family receptor
I6K98_RS09395	COG0114	fumarate hydratase activity
I6K98_RS09400	COG0802	atpase or kinase
I6K98_RS09405	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K98_RS09410	COG0586	Pfam SNARE associated Golgi protein
I6K98_RS09415	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6K98_RS09420	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6K98_RS09425	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6K98_RS09445	COG0617	tRNA 3'-terminal CCA addition
I6K98_RS09470	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6K98_RS09475	COG2188	Transcriptional regulator
I6K98_RS09485	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K98_RS09495	COG1028	Short-chain dehydrogenase reductase Sdr
I6K98_RS09515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6K98_RS09530	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K98_RS09540	COG1414	Transcriptional regulator
I6K98_RS09545	COG1028	Short-chain dehydrogenase reductase Sdr
I6K98_RS09550	COG2031	fatty acid transporter
I6K98_RS09555	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K98_RS09565	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6K98_RS09570	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6K98_RS09580	COG4257	antibiotic catabolic process
I6K98_RS09605	COG1012	belongs to the aldehyde dehydrogenase family
I6K98_RS09610	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6K98_RS09615	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K98_RS09655	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6K98_RS09655	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6K98_RS09660	COG0509	glycine decarboxylation via glycine cleavage system
I6K98_RS09665	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6K98_RS09675	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6K98_RS09685	COG2081	HI0933 family
I6K98_RS09715	COG0717	Belongs to the dCTP deaminase family
I6K98_RS09730	COG0489	protein tyrosine kinase activity
I6K98_RS09740	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K98_RS09740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K98_RS09745	COG1054	Belongs to the UPF0176 family
I6K98_RS09780	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6K98_RS09785	COG1280	lysine exporter protein (LysE YggA)
I6K98_RS09790	COG0513	Belongs to the DEAD box helicase family
I6K98_RS09800	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6K98_RS09820	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6K98_RS09835	COG2226	methyltransferase
I6K98_RS09840	COG0745	RESPONSE REGULATOR receiver
I6K98_RS09845	COG5002	protein histidine kinase activity
I6K98_RS09855	COG5002	protein histidine kinase activity
I6K98_RS09865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K98_RS09870	COG0583	DNA-binding transcription factor activity
I6K98_RS09880	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6K98_RS09885	COG1984	allophanate hydrolase subunit 2
I6K98_RS09900	COG3181	Tripartite tricarboxylate transporter family receptor
I6K98_RS09915	COG1024	Enoyl-CoA hydratase
I6K98_RS09930	COG1802	Transcriptional regulator
I6K98_RS09945	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K98_RS09965	COG0583	DNA-binding transcription factor activity
I6K98_RS09975	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6K98_RS09985	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6K98_RS09990	COG0154	amidase activity
I6K98_RS10000	COG1609	Transcriptional regulator
I6K98_RS10020	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6K98_RS10035	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K98_RS10040	COG3842	ATPase activity
I6K98_RS10045	COG1653	transport
I6K98_RS10050	COG1175	transmembrane transport
I6K98_RS10055	COG0395	ABC-type sugar transport system, permease component
I6K98_RS10075	COG0018	arginyl-trna synthetase
I6K98_RS10085	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K98_RS10120	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6K98_RS10125	COG0321	lipoyl(octanoyl) transferase activity
I6K98_RS10130	COG2921	Belongs to the UPF0250 family
I6K98_RS10140	COG1686	Belongs to the peptidase S11 family
I6K98_RS10160	COG1127	ABC transporter
I6K98_RS10165	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6K98_RS10175	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6K98_RS10190	COG0859	PFAM glycosyl transferase family 9
I6K98_RS10220	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6K98_RS10225	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6K98_RS10230	COG0438	transferase activity, transferring glycosyl groups
I6K98_RS10260	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6K98_RS10265	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K98_RS10280	COG0625	glutathione transferase activity
I6K98_RS10285	COG0326	Molecular chaperone. Has ATPase activity
I6K98_RS10315	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6K98_RS10380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K98_RS10385	COG0765	amino acid transport
I6K98_RS10390	COG0765	amino acid transport
I6K98_RS10395	COG1126	abc transporter atp-binding protein
I6K98_RS10400	COG1794	racemase activity, acting on amino acids and derivatives
I6K98_RS10410	COG2223	nitrite transmembrane transporter activity
I6K98_RS10420	COG2813	Specifically methylates the guanine in position
I6K98_RS10420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6K98_RS10425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6K98_RS10470	COG0242	peptide deformylase activity
I6K98_RS10485	COG0204	Acyl-transferase
I6K98_RS10490	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6K98_RS10495	COG0751	glycine-tRNA ligase activity
I6K98_RS10500	COG0752	glycyl-tRNA synthetase alpha subunit
I6K98_RS10520	COG1024	Enoyl-CoA hydratase
I6K98_RS10545	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K98_RS10585	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6K98_RS10590	COG0085	RNA polymerase activity
I6K98_RS10595	COG0222	ribosome binding
I6K98_RS10600	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6K98_RS10605	COG0081	regulation of translation
I6K98_RS10610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6K98_RS10620	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6K98_RS10630	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6K98_RS10655	COG1475	DNA binding
I6K98_RS10665	COG1192	Involved in chromosome partitioning
I6K98_RS10670	COG0357	Ribosomal RNA small subunit methyltransferase G
I6K98_RS10675	COG0445	tRNA wobble uridine modification
I6K98_RS10680	COG1278	Cold shock
I6K98_RS10685	COG0436	Aminotransferase
I6K98_RS10720	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6K98_RS10725	COG0747	negative chemotaxis
I6K98_RS10740	COG0444	Belongs to the ABC transporter superfamily
I6K98_RS10745	COG4608	Belongs to the ABC transporter superfamily
I6K98_RS10750	COG1473	amidohydrolase
I6K98_RS10755	COG2175	clavaminate synthase activity
I6K98_RS10765	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6K98_RS10770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K98_RS10775	COG0753	catalase activity
I6K98_RS10790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K98_RS10795	COG1024	Enoyl-CoA hydratase
I6K98_RS10815	COG1024	Enoyl-CoA hydratase
I6K98_RS10830	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K98_RS10835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K98_RS10845	COG2226	methyltransferase
I6K98_RS10855	COG1194	a g-specific adenine glycosylase
I6K98_RS10865	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I6K98_RS10870	COG2177	Part of the ABC transporter FtsEX involved in
I6K98_RS10875	COG2884	Cell division ATP-binding protein ftsE
I6K98_RS10880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K98_RS10885	COG4597	amino acid ABC transporter
I6K98_RS10890	COG0765	amino acid transport
I6K98_RS10895	COG1126	abc transporter atp-binding protein
I6K98_RS10910	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6K98_RS10915	COG0477	Major facilitator Superfamily
I6K98_RS10925	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6K98_RS10930	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6K98_RS10945	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6K98_RS10950	COG0237	dephospho-CoA kinase activity
I6K98_RS10955	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I6K98_RS10990	COG0494	nUDIX hydrolase
I6K98_RS11000	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6K98_RS11015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K98_RS11020	COG0601	transmembrane transport
I6K98_RS11025	COG0747	negative chemotaxis
I6K98_RS11030	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6K98_RS11050	COG0697	spore germination
I6K98_RS11060	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
I6K98_RS11065	COG2948	multi-organism process
I6K98_RS11070	COG3504	Conjugal transfer protein
I6K98_RS11075	COG3736	Type IV secretory pathway, component VirB8
I6K98_RS11090	COG3451	type IV secretory pathway VirB4
I6K98_RS11095	COG3702	type iv secretory pathway
I6K98_RS11130	COG3181	Tripartite tricarboxylate transporter family receptor
I6K98_RS11155	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6K98_RS11160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6K98_RS11165	COG0537	adenosine 5'-monophosphoramidase activity
I6K98_RS11170	COG0140	phosphoribosyl-ATP diphosphatase activity
I6K98_RS11175	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6K98_RS11180	COG0107	imidazoleglycerol-phosphate synthase activity
I6K98_RS11185	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6K98_RS11190	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6K98_RS11195	COG0131	Imidazoleglycerol-phosphate dehydratase
I6K98_RS11200	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6K98_RS11205	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6K98_RS11210	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6K98_RS11215	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6K98_RS11225	COG0842	Transport permease protein
I6K98_RS11240	COG2853	Lipoprotein
I6K98_RS11245	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K98_RS11250	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6K98_RS11255	COG1127	ABC transporter
I6K98_RS11265	COG3047	cAMP biosynthetic process
I6K98_RS11275	COG0069	glutamate synthase activity
I6K98_RS11275	COG0070	glutamate synthase
I6K98_RS11275	COG0067	glutamate synthase
I6K98_RS11285	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6K98_RS11290	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6K98_RS11300	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K98_RS11305	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K98_RS11325	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6K98_RS11360	COG0109	protoheme IX farnesyltransferase activity
I6K98_RS11365	COG1999	signal sequence binding
I6K98_RS11385	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6K98_RS11390	COG2814	Major facilitator Superfamily
I6K98_RS11475	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K98_RS11480	COG2816	NAD+ diphosphatase activity
I6K98_RS11485	COG1309	transcriptional regulator
I6K98_RS11490	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K98_RS11505	COG1024	Enoyl-CoA hydratase
I6K98_RS11520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K98_RS11535	COG3181	Tripartite tricarboxylate transporter family receptor
I6K98_RS11565	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6K98_RS11580	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6K98_RS11595	COG1652	LysM domain
I6K98_RS11605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K98_RS11610	COG1956	GAF domain-containing protein
I6K98_RS11615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K98_RS11640	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6K98_RS11660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K98_RS11680	COG0438	transferase activity, transferring glycosyl groups
I6K98_RS11690	COG0402	S-adenosylhomocysteine deaminase activity
I6K98_RS11730	COG0629	single-stranded DNA binding
I6K98_RS11735	COG2814	Major facilitator Superfamily
I6K98_RS11750	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6K98_RS11755	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6K98_RS11760	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6K98_RS11770	COG1965	Belongs to the frataxin family
I6K98_RS11780	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K98_RS11785	COG1333	cytochrome c biogenesis protein
I6K98_RS11795	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6K98_RS11810	COG4232	protein-disulfide reductase activity
I6K98_RS11815	COG1324	tolerance protein
I6K98_RS11820	COG0537	adenosine 5'-monophosphoramidase activity
I6K98_RS11825	COG0203	ribosomal protein L17
I6K98_RS11830	COG0202	RNA polymerase activity
I6K98_RS11835	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6K98_RS11840	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6K98_RS11845	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6K98_RS11850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6K98_RS11855	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6K98_RS11860	COG0201	protein transport
I6K98_RS11865	COG0200	Binds to the 23S rRNA
I6K98_RS11870	COG1841	ribosomal large subunit assembly
I6K98_RS11875	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6K98_RS11880	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6K98_RS11885	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6K98_RS11890	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6K98_RS11895	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6K98_RS11900	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6K98_RS11905	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6K98_RS11910	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6K98_RS11930	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6K98_RS11935	COG0255	Belongs to the universal ribosomal protein uL29 family
I6K98_RS11940	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6K98_RS11945	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6K98_RS11950	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6K98_RS11955	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6K98_RS11960	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6K98_RS11965	COG0089	rRNA binding
I6K98_RS11970	COG0088	Forms part of the polypeptide exit tunnel
I6K98_RS11975	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6K98_RS11980	COG0051	transcription antitermination factor activity, RNA binding
I6K98_RS11985	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6K98_RS11990	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6K98_RS11995	COG0049	tRNA binding
I6K98_RS12000	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6K98_RS12010	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6K98_RS12020	COG0628	permease
I6K98_RS12030	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6K98_RS12040	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6K98_RS12045	COG0351	phosphomethylpyrimidine kinase
I6K98_RS12050	COG2022	thiamine diphosphate biosynthetic process
I6K98_RS12055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K98_RS12060	COG4206	TonB-dependent receptor
I6K98_RS12080	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6K98_RS12085	COG0159	tryptophan synthase activity
I6K98_RS12090	COG0133	tryptophan synthase activity
I6K98_RS12100	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K98_RS12105	COG3228	Belongs to the MtfA family
I6K98_RS12115	COG0251	oxidation-reduction process
I6K98_RS12120	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6K98_RS12125	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6K98_RS12140	COG2878	Part of a membrane complex involved in electron transport
I6K98_RS12145	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6K98_RS12180	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6K98_RS12200	COG1268	BioY protein
I6K98_RS12205	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6K98_RS12210	COG1122	ATPase activity
I6K98_RS12215	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6K98_RS12230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K98_RS12235	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6K98_RS12245	COG1196	nuclear chromosome segregation
I6K98_RS12250	COG0477	Major facilitator Superfamily
I6K98_RS12255	COG1573	uracil-dna glycosylase
I6K98_RS12260	COG1214	PFAM Peptidase M22, glycoprotease
I6K98_RS12275	COG0450	alkyl hydroperoxide reductase
I6K98_RS12280	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K98_RS12290	COG2223	nitrite transmembrane transporter activity
I6K98_RS12300	COG2186	Transcriptional regulator
I6K98_RS12320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6K98_RS12330	COG0583	DNA-binding transcription factor activity
I6K98_RS12340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K98_RS12345	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6K98_RS12350	COG0137	argininosuccinate synthase activity
I6K98_RS12355	COG3158	transport of potassium into the cell
I6K98_RS12360	COG0642	Histidine kinase
I6K98_RS12390	COG0776	regulation of translation
I6K98_RS12395	COG3128	pkhd-type hydroxylase
I6K98_RS12405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K98_RS12410	COG0557	exoribonuclease II activity
I6K98_RS12435	COG0679	Auxin Efflux Carrier
I6K98_RS12440	COG2391	methyltransferase activity
I6K98_RS12445	COG0069	glutamate synthase activity
I6K98_RS12465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K98_RS12475	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I6K98_RS12525	COG3706	GGDEF domain
I6K98_RS12540	COG1053	succinate dehydrogenase
I6K98_RS12545	COG0583	DNA-binding transcription factor activity
I6K98_RS12555	COG1053	succinate dehydrogenase
I6K98_RS12575	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6K98_RS12580	COG0459	protein refolding
I6K98_RS12585	COG3468	outer membrane autotransporter barrel domain protein
I6K98_RS12600	COG1252	NADH dehydrogenase
I6K98_RS12605	COG0284	orotidine-5'-phosphate decarboxylase activity
I6K98_RS12610	COG1546	Belongs to the CinA family
I6K98_RS12610	COG1058	Belongs to the CinA family
I6K98_RS12615	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6K98_RS12625	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6K98_RS12630	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6K98_RS12670	COG3639	organic phosphonate transmembrane transporter activity
I6K98_RS12675	COG3639	organic phosphonate transmembrane transporter activity
I6K98_RS12695	COG0742	ribosomal rna small subunit methyltransferase
I6K98_RS12700	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6K98_RS12705	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K98_RS12710	COG3135	benzoate transporter
I6K98_RS12725	COG0640	Transcriptional regulator
I6K98_RS12755	COG4172	Belongs to the ABC transporter superfamily
I6K98_RS12760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K98_RS12765	COG0601	transmembrane transport
I6K98_RS12775	COG0280	phosphate acetyltransferase
I6K98_RS12775	COG0281	malic enzyme
I6K98_RS12835	COG0583	DNA-binding transcription factor activity
I6K98_RS12850	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I6K98_RS12855	COG0167	dihydroorotate dehydrogenase activity
I6K98_RS12875	COG1414	Transcriptional regulator
I6K98_RS12880	COG1546	Belongs to the CinA family
I6K98_RS12880	COG1058	Belongs to the CinA family
I6K98_RS12895	COG1464	Belongs to the NlpA lipoprotein family
I6K98_RS12925	COG4211	Belongs to the binding-protein-dependent transport system permease family
I6K98_RS12935	COG0154	amidase activity
I6K98_RS12940	COG0288	reversible hydration of carbon dioxide
I6K98_RS12955	COG0514	ATP-dependent DNA helicase (RecQ)
I6K98_RS12960	COG2255	four-way junction helicase activity
I6K98_RS12975	COG0632	four-way junction helicase activity
I6K98_RS12980	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6K98_RS13000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K98_RS13010	COG0006	proline dipeptidase activity
I6K98_RS13040	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K98_RS13055	COG4783	chaperone-mediated protein folding
I6K98_RS13060	COG0429	hydrolase of the alpha beta-hydrolase fold
I6K98_RS13090	COG0513	Belongs to the DEAD box helicase family
I6K98_RS13235	COG1196	nuclear chromosome segregation
I6K98_RS13305	COG2135	peptidase activity
I6K98_RS13320	COG0494	nUDIX hydrolase
I6K98_RS13325	COG0442	prolyl-tRNA aminoacylation
I6K98_RS13330	COG0824	Thioesterase
I6K98_RS13335	COG0811	peptide transport
I6K98_RS13340	COG0848	biopolymer transport protein
I6K98_RS13350	COG0823	Involved in the tonB-independent uptake of proteins
I6K98_RS13365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K98_RS13370	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6K98_RS13400	COG0700	Nucleoside recognition
I6K98_RS13405	COG0469	pyruvate kinase activity
I6K98_RS13410	COG1929	Belongs to the glycerate kinase type-1 family
I6K98_RS13415	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6K98_RS13420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K98_RS13425	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6K98_RS13435	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6K98_RS13445	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6K98_RS13465	COG0154	amidase activity
I6K98_RS13475	COG1414	Transcriptional regulator
I6K98_RS13485	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K98_RS13485	COG1024	Enoyl-CoA hydratase
I6K98_RS13495	COG2132	Multicopper oxidase
I6K98_RS13550	COG1024	Enoyl-CoA hydratase
I6K98_RS13555	COG1024	Enoyl-CoA hydratase
I6K98_RS13560	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6K98_RS13580	COG0601	transmembrane transport
I6K98_RS13585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K98_RS13590	COG4172	Belongs to the ABC transporter superfamily
I6K98_RS13600	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6K98_RS13610	COG0210	DNA helicase
I6K98_RS13615	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6K98_RS13620	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6K98_RS13630	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6K98_RS13635	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6K98_RS13640	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6K98_RS13645	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6K98_RS13650	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6K98_RS13655	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6K98_RS13665	COG0356	it plays a direct role in the translocation of protons across the membrane
I6K98_RS13690	COG1024	Enoyl-CoA hydratase
I6K98_RS13695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K98_RS13700	COG3634	alkyl hydroperoxide reductase activity
I6K98_RS13710	COG0037	tRNA processing
I6K98_RS13720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K98_RS13725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K98_RS13730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K98_RS13735	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6K98_RS13740	COG2967	ApaG domain
I6K98_RS13745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K98_RS13750	COG0546	phosphoglycolate phosphatase activity
I6K98_RS13760	COG0512	Glutamine amidotransferase of anthranilate synthase
I6K98_RS13765	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K98_RS13770	COG0134	indole-3-glycerol-phosphate synthase activity
I6K98_RS13800	COG0583	DNA-binding transcription factor activity
I6K98_RS13815	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K98_RS13820	COG0259	pyridoxamine-phosphate oxidase activity
I6K98_RS13830	COG2814	Major facilitator Superfamily
I6K98_RS13835	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6K98_RS13840	COG2188	Transcriptional regulator
I6K98_RS13845	COG0318	PFAM AMP-dependent synthetase and ligase
I6K98_RS13865	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6K98_RS13875	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6K98_RS13885	COG1215	transferase activity, transferring glycosyl groups
I6K98_RS13895	COG0601	transmembrane transport
I6K98_RS13930	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6K98_RS13935	COG2894	cell division
I6K98_RS13940	COG0850	regulation of cytokinetic process
I6K98_RS13945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6K98_RS13950	COG1271	oxidase subunit
I6K98_RS13985	COG2979	Protein of unknown function (DUF533)
I6K98_RS14005	COG1388	LysM domain
I6K98_RS14005	COG0741	lytic transglycosylase activity
I6K98_RS14010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K98_RS14015	COG2226	methyltransferase
I6K98_RS14020	COG0328	RNA-DNA hybrid ribonuclease activity
I6K98_RS14065	COG2030	dehydratase
I6K98_RS14115	COG1960	acyl-CoA dehydrogenase activity
I6K98_RS14130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K98_RS14155	COG2718	Belongs to the UPF0229 family
I6K98_RS14160	COG2719	SpoVR family
I6K98_RS14185	COG2188	Transcriptional regulator
I6K98_RS14215	COG0829	nickel cation binding
I6K98_RS14220	COG0831	urea catabolic process
I6K98_RS14230	COG0832	Belongs to the urease beta subunit family
I6K98_RS14235	COG0804	urea catabolic process
I6K98_RS14245	COG0830	nickel cation binding
I6K98_RS14250	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6K98_RS14270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K98_RS14275	COG0601	transmembrane transport
I6K98_RS14280	COG0747	negative chemotaxis
I6K98_RS14290	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K98_RS14295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K98_RS14305	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6K98_RS14315	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
I6K98_RS14320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6K98_RS14325	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6K98_RS14340	COG0438	transferase activity, transferring glycosyl groups
I6K98_RS14355	COG0438	transferase activity, transferring glycosyl groups
I6K98_RS14360	COG0438	transferase activity, transferring glycosyl groups
I6K98_RS14365	COG0166	Belongs to the GPI family
I6K98_RS14380	COG0277	FAD linked oxidase domain protein
I6K98_RS14385	COG0745	RESPONSE REGULATOR receiver
I6K98_RS14390	COG0642	Histidine kinase
I6K98_RS14395	COG1368	sulfuric ester hydrolase activity
I6K98_RS14405	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I6K98_RS14430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6K98_RS14440	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6K98_RS14445	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6K98_RS14455	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6K98_RS14460	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6K98_RS14465	COG0193	aminoacyl-tRNA hydrolase activity
I6K98_RS14475	COG0012	GTP binding
I6K98_RS14480	COG0582	viral genome integration into host DNA
I6K98_RS14500	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6K98_RS14545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K98_RS14555	COG0405	Gamma-glutamyltransferase
I6K98_RS14585	COG4772	TonB-dependent receptor
I6K98_RS14625	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6K98_RS14630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K98_RS14645	COG2096	Adenosyltransferase
I6K98_RS14655	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6K98_RS14660	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6K98_RS14670	COG0523	cobalamin synthesis protein
I6K98_RS14675	COG0735	belongs to the Fur family
I6K98_RS14695	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6K98_RS14705	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6K98_RS14715	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6K98_RS14725	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6K98_RS14730	COG1560	Kdo2-lipid A biosynthetic process
I6K98_RS14740	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6K98_RS14755	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6K98_RS14760	COG1950	PFAM Membrane protein of
I6K98_RS14775	COG0583	DNA-binding transcription factor activity
I6K98_RS14785	COG0477	Major facilitator Superfamily
I6K98_RS14800	COG0617	tRNA 3'-terminal CCA addition
I6K98_RS14810	COG0513	Belongs to the DEAD box helicase family
I6K98_RS14815	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6K98_RS14830	COG2084	Dehydrogenase
I6K98_RS14880	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6K98_RS14885	COG0129	dihydroxy-acid dehydratase activity
I6K98_RS14890	COG4654	Cytochrome c, class I
I6K98_RS14895	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6K98_RS14945	COG1473	amidohydrolase
I6K98_RS14950	COG0418	dihydroorotase activity
I6K98_RS14955	COG0488	(ABC) transporter
I6K98_RS14965	COG2001	Belongs to the MraZ family
I6K98_RS14970	COG0275	rRNA processing
I6K98_RS14975	COG3116	cell division
I6K98_RS14985	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K98_RS14990	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6K98_RS14995	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6K98_RS15005	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6K98_RS15010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6K98_RS15015	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6K98_RS15020	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6K98_RS15030	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6K98_RS15035	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I6K98_RS15045	COG0739	heme binding
I6K98_RS15050	COG0653	protein targeting
I6K98_RS15070	COG1028	Short-chain dehydrogenase reductase Sdr
I6K98_RS15075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K98_RS15080	COG1522	sequence-specific DNA binding
I6K98_RS15105	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6K98_RS15115	COG0557	exoribonuclease II activity
I6K98_RS15120	COG3150	esterase
I6K98_RS15125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6K98_RS15130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K98_RS15135	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6K98_RS15140	COG0511	ligase activity, forming carbon-carbon bonds
I6K98_RS15145	COG0439	Biotin carboxylase
I6K98_RS15160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K98_RS15180	COG1696	Membrane protein involved in D-alanine export
I6K98_RS15185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K98_RS15220	COG1522	sequence-specific DNA binding
I6K98_RS15235	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6K98_RS15240	COG0045	succinate-CoA ligase (ADP-forming) activity
I6K98_RS15240	COG1042	CoA-binding domain protein
I6K98_RS15240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K98_RS15250	COG1802	Transcriptional regulator
I6K98_RS15255	COG3069	C4-dicarboxylate transmembrane transporter activity
I6K98_RS15260	COG0513	Belongs to the DEAD box helicase family
I6K98_RS15265	COG0346	lactoylglutathione lyase activity
I6K98_RS15270	COG1335	isochorismatase
I6K98_RS15275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K98_RS15280	COG1116	anion transmembrane transporter activity
I6K98_RS15295	COG3028	Belongs to the UPF0307 family
I6K98_RS15300	COG0312	modulator of DNA gyrase
I6K98_RS15305	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6K98_RS15310	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6K98_RS15315	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6K98_RS15320	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6K98_RS15330	COG0316	Belongs to the HesB IscA family
I6K98_RS15335	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6K98_RS15350	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6K98_RS15360	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6K98_RS15365	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6K98_RS15380	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K98_RS15380	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K98_RS15410	COG0583	DNA-binding transcription factor activity
I6K98_RS15415	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K98_RS15450	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
I6K98_RS15460	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6K98_RS15465	COG1845	cytochrome c oxidase, subunit III
I6K98_RS15470	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6K98_RS15475	COG0640	Transcriptional regulator
I6K98_RS15495	COG3220	belongs to the UPF0276 family
I6K98_RS15540	COG1666	GTP binding
I6K98_RS15575	COG0312	modulator of DNA gyrase
I6K98_RS15580	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K98_RS15585	COG3064	Membrane
I6K98_RS15585	COG3064	Membrane
I6K98_RS15585	COG3210	domain, Protein
I6K98_RS15585	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
I6K98_RS15585	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
I6K98_RS15585	COG3210	domain, Protein
I6K98_RS15590	COG0277	FAD linked oxidase domain protein
I6K98_RS15595	COG0277	FAD linked oxidase domain protein
I6K98_RS15600	COG0277	FAD linked oxidase domain protein
I6K98_RS15605	COG0247	lactate metabolic process
I6K98_RS15610	COG2819	hydrolase of the alpha beta superfamily
I6K98_RS15650	COG0583	DNA-binding transcription factor activity
I6K98_RS15655	COG0482	sulfurtransferase activity
I6K98_RS15660	COG0730	response to heat
I6K98_RS15665	COG0625	glutathione transferase activity
I6K98_RS15670	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6K98_RS15675	COG3909	cytochrome
I6K98_RS15710	COG0583	DNA-binding transcription factor activity
I6K98_RS15720	COG0590	tRNA wobble adenosine to inosine editing
I6K98_RS15725	COG2807	transmembrane transport
I6K98_RS15750	COG0154	amidase activity
I6K98_RS15755	COG0307	riboflavin synthase, alpha
I6K98_RS15760	COG3181	Tripartite tricarboxylate transporter family receptor
I6K98_RS15765	COG1522	sequence-specific DNA binding
I6K98_RS15775	COG0318	PFAM AMP-dependent synthetase and ligase
I6K98_RS15785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K98_RS15805	COG1063	alcohol dehydrogenase
I6K98_RS15830	COG1418	mRNA catabolic process
I6K98_RS15835	COG1448	Aminotransferase
I6K98_RS15840	COG0583	DNA-binding transcription factor activity
I6K98_RS15850	COG0477	Major facilitator Superfamily
I6K98_RS15855	COG1028	Short-chain dehydrogenase reductase Sdr
I6K98_RS15870	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K98_RS15875	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6K98_RS15880	COG0583	DNA-binding transcription factor activity
I6K98_RS15925	COG1028	Short-chain dehydrogenase reductase Sdr
I6K98_RS15930	COG1309	transcriptional regulator
I6K98_RS15935	COG2982	Protein involved in outer membrane biogenesis
I6K98_RS15940	COG2818	Glycosylase
I6K98_RS15960	COG1653	transport
I6K98_RS15980	COG3842	ATPase activity
I6K98_RS15985	COG0395	ABC-type sugar transport system, permease component
I6K98_RS15990	COG1175	transmembrane transport
I6K98_RS16005	COG3181	Tripartite tricarboxylate transporter family receptor
I6K98_RS16010	COG2186	Transcriptional regulator
I6K98_RS16035	COG1454	alcohol dehydrogenase
I6K98_RS16055	COG2011	ABC-type metal ion transport system permease component
I6K98_RS16060	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6K98_RS16065	COG1501	Belongs to the glycosyl hydrolase 31 family
I6K98_RS16085	COG0318	PFAM AMP-dependent synthetase and ligase
I6K98_RS16090	COG1473	amidohydrolase
I6K98_RS16100	COG2855	membrane
I6K98_RS16110	COG2239	Acts as a magnesium transporter
I6K98_RS16130	COG3181	Tripartite tricarboxylate transporter family receptor
I6K98_RS16140	COG1722	exodeoxyribonuclease VII activity
I6K98_RS16145	COG0142	geranyltranstransferase activity
I6K98_RS16150	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6K98_RS16155	COG1469	GTP cyclohydrolase I activity
I6K98_RS16160	COG0360	Binds together with S18 to 16S ribosomal RNA
I6K98_RS16165	COG2965	DNA replication, synthesis of RNA primer
I6K98_RS16170	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6K98_RS16175	COG0359	binds to the 23S rRNA
I6K98_RS16185	COG0305	Participates in initiation and elongation during chromosome replication
I6K98_RS16195	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6K98_RS16200	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6K98_RS16205	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6K98_RS16210	COG3737	Protein of unknown function (DUF498/DUF598)
I6K98_RS16215	COG0436	Aminotransferase
I6K98_RS16240	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6K98_RS16270	COG0268	Binds directly to 16S ribosomal RNA
I6K98_RS16280	COG0728	peptidoglycan biosynthetic process
I6K98_RS16290	COG0563	adenylate kinase activity
I6K98_RS16295	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6K98_RS16300	COG2835	tetraacyldisaccharide 4'-kinase activity
I6K98_RS16305	COG1663	tetraacyldisaccharide 4'-kinase activity
I6K98_RS16310	COG0848	biopolymer transport protein
I6K98_RS16315	COG0811	peptide transport
I6K98_RS16325	COG1570	exodeoxyribonuclease VII activity
I6K98_RS16330	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6K98_RS16335	COG0038	chloride channel
I6K98_RS16340	COG0183	Belongs to the thiolase family
I6K98_RS16350	COG1278	Cold shock
I6K98_RS16355	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6K98_RS16365	COG4953	penicillin-binding protein 1C
I6K98_RS16370	COG0542	response to heat
I6K98_RS16375	COG2995	paraquat-inducible protein a
I6K98_RS16380	COG3008	intermembrane lipid transfer
I6K98_RS16380	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K98_RS16390	COG0506	proline dehydrogenase activity
I6K98_RS16390	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K98_RS16390	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K98_RS16425	COG2271	Major facilitator Superfamily
I6K98_RS16430	COG1309	transcriptional regulator
I6K98_RS16465	COG0477	Major facilitator Superfamily
I6K98_RS16475	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6K98_RS16480	COG1845	cytochrome c oxidase, subunit III
I6K98_RS16485	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6K98_RS16495	COG1028	Short-chain dehydrogenase reductase Sdr
I6K98_RS16510	COG0789	Transcriptional regulator
I6K98_RS16535	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6K98_RS16540	COG0697	spore germination
I6K98_RS16550	COG0678	peroxiredoxin activity
I6K98_RS16560	COG0412	Dienelactone hydrolase
I6K98_RS16570	COG0315	cyclic pyranopterin monophosphate synthase activity
I6K98_RS16585	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K98_RS16590	COG0303	'Molybdopterin
I6K98_RS16595	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6K98_RS16615	COG0165	Argininosuccinate lyase
I6K98_RS16620	COG0668	transmembrane transport
I6K98_RS16665	COG0747	negative chemotaxis
I6K98_RS16670	COG0601	transmembrane transport
I6K98_RS16685	COG1162	GTPase activity
I6K98_RS16690	COG0501	Belongs to the peptidase M48B family
I6K98_RS16695	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6K98_RS16705	COG3327	negative regulation of DNA-templated transcription, initiation
I6K98_RS16710	COG3396	Phenylacetate-CoA oxygenase
I6K98_RS16715	COG3460	Phenylacetate-CoA oxygenase
I6K98_RS16720	COG3396	Phenylacetate-CoA oxygenase
I6K98_RS16725	COG2151	metal-sulfur cluster biosynthetic enzyme
I6K98_RS16740	COG1012	belongs to the aldehyde dehydrogenase family
I6K98_RS16745	COG1024	Enoyl-CoA hydratase
I6K98_RS16750	COG2050	protein possibly involved in aromatic compounds catabolism
I6K98_RS16760	COG3539	Fimbrial protein
I6K98_RS16780	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6K98_RS16785	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6K98_RS16785	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6K98_RS16790	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6K98_RS16795	COG0047	phosphoribosylformylglycinamidine synthase activity
I6K98_RS16795	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6K98_RS16800	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
I6K98_RS16800	COG3210	domain, Protein
I6K98_RS16800	COG3064	Membrane
I6K98_RS16825	COG0235	Class ii aldolase
I6K98_RS16830	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6K98_RS16835	COG0720	synthase
I6K98_RS16840	COG0602	queuosine metabolic process
I6K98_RS16865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K98_RS16900	COG3181	Tripartite tricarboxylate transporter family receptor
I6K98_RS16930	COG3842	ATPase activity
I6K98_RS16940	COG0395	ABC-type sugar transport system, permease component
I6K98_RS16970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K98_RS16975	COG0420	3'-5' exonuclease activity
I6K98_RS17015	COG0519	Catalyzes the synthesis of GMP from XMP
I6K98_RS17015	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6K98_RS17025	COG3550	peptidyl-serine autophosphorylation
I6K98_RS17035	COG0477	Major facilitator Superfamily
I6K98_RS17050	COG1228	amidohydrolase
I6K98_RS17060	COG1116	anion transmembrane transporter activity
I6K98_RS17065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K98_RS17090	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6K98_RS17105	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6K98_RS17135	COG2814	Major facilitator Superfamily
I6K98_RS17150	COG1280	lysine exporter protein (LysE YggA)
I6K98_RS17165	COG0747	negative chemotaxis
I6K98_RS17170	COG0601	transmembrane transport
I6K98_RS17175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K98_RS17180	COG4172	Belongs to the ABC transporter superfamily
I6K98_RS17185	COG1609	Transcriptional regulator
I6K98_RS17215	COG0586	Pfam SNARE associated Golgi protein
I6K98_RS17225	COG0500	methyltransferase
I6K98_RS17240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K98_RS17250	COG0756	dUTP diphosphatase activity
I6K98_RS17260	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6K98_RS17265	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6K98_RS17270	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6K98_RS17275	COG0072	phenylalanine-tRNA ligase activity
I6K98_RS17275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K98_RS17280	COG0776	regulation of translation
I6K98_RS17345	COG0540	Belongs to the ATCase OTCase family
I6K98_RS17350	COG2974	May be involved in recombination
I6K98_RS17360	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K98_RS17365	COG0583	DNA-binding transcription factor activity
I6K98_RS17385	COG1028	Short-chain dehydrogenase reductase Sdr
I6K98_RS17400	COG3842	ATPase activity
I6K98_RS17405	COG1024	Enoyl-CoA hydratase
I6K98_RS17405	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K98_RS17425	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6K98_RS17430	COG2137	regulation of response to DNA damage stimulus
I6K98_RS17440	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6K98_RS17450	COG0045	succinate-CoA ligase (ADP-forming) activity
I6K98_RS17455	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K98_RS17460	COG0861	Integral membrane protein TerC family
I6K98_RS17465	COG0861	Integral membrane protein TerC family
I6K98_RS17470	COG0181	hydroxymethylbilane synthase activity
I6K98_RS17530	COG4964	Belongs to the GSP D family
I6K98_RS17555	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6K98_RS17565	COG0583	DNA-binding transcription factor activity
I6K98_RS17575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K98_RS17580	COG4311	Sarcosine oxidase, delta subunit
I6K98_RS17585	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6K98_RS17585	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6K98_RS17620	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6K98_RS17625	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6K98_RS17630	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K98_RS17635	COG0735	belongs to the Fur family
I6K98_RS17640	COG0497	DNA recombination
I6K98_RS17645	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6K98_RS17650	COG1420	regulation of RNA biosynthetic process
I6K98_RS17655	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6K98_RS17665	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6K98_RS17675	COG0443	Heat shock 70 kDa protein
I6K98_RS17680	COG0484	heat shock protein binding
I6K98_RS17685	COG0612	Peptidase, M16
I6K98_RS17705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6K98_RS17750	COG0745	RESPONSE REGULATOR receiver
I6K98_RS17760	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6K98_RS17765	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6K98_RS17770	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6K98_RS17785	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6K98_RS17800	COG1193	negative regulation of DNA recombination
I6K98_RS17805	COG0492	ferredoxin-NADP+ reductase activity
I6K98_RS17810	COG1674	ftsk spoiiie
I6K98_RS17815	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6K98_RS17820	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6K98_RS17825	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6K98_RS17850	COG3706	GGDEF domain
I6K98_RS17870	COG2814	Major facilitator Superfamily
I6K98_RS17900	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I6K98_RS17915	COG1028	Short-chain dehydrogenase reductase Sdr
I6K98_RS17925	COG3022	response to hydroperoxide
I6K98_RS17940	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K98_RS17950	COG0424	maF-like protein
I6K98_RS17955	COG1399	metal-binding, possibly nucleic acid-binding protein
I6K98_RS17960	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6K98_RS17965	COG0416	fatty acid biosynthetic process
I6K98_RS17970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6K98_RS17985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6K98_RS17990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K98_RS18015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K98_RS18020	COG0481	GTPase activity
I6K98_RS18025	COG0681	Belongs to the peptidase S26 family
I6K98_RS18030	COG0571	ribonuclease III activity
I6K98_RS18035	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6K98_RS18040	COG1381	Involved in DNA repair and RecF pathway recombination
I6K98_RS18065	COG3181	Tripartite tricarboxylate transporter family receptor
I6K98_RS18070	COG0670	Belongs to the BI1 family
I6K98_RS18085	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6K98_RS18095	COG0583	DNA-binding transcription factor activity
I6K98_RS18110	COG0583	DNA-binding transcription factor activity
I6K98_RS18125	COG0791	NLP P60 protein
I6K98_RS18135	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6K98_RS18145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K98_RS18150	COG0697	spore germination
I6K98_RS18155	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6K98_RS18170	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6K98_RS18200	COG1446	asparaginase
I6K98_RS18205	COG4172	Belongs to the ABC transporter superfamily
I6K98_RS18210	COG0747	negative chemotaxis
I6K98_RS18220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K98_RS18245	COG0504	CTP synthase activity
I6K98_RS18250	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6K98_RS18260	COG0148	phosphopyruvate hydratase activity
I6K98_RS18265	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6K98_RS18295	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6K98_RS18305	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K98_RS18330	COG1981	membrane
I6K98_RS18360	COG0039	L-malate dehydrogenase activity
I6K98_RS18365	COG2188	Transcriptional regulator
I6K98_RS18370	COG2009	succinate dehydrogenase
I6K98_RS18375	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6K98_RS18380	COG1053	succinate dehydrogenase
I6K98_RS18385	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K98_RS18390	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6K98_RS18395	COG0372	Belongs to the citrate synthase family
I6K98_RS18410	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6K98_RS18410	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6K98_RS18420	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6K98_RS18425	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6K98_RS18440	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K98_RS18445	COG3842	ATPase activity
I6K98_RS18450	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K98_RS18455	COG1177	transmembrane transport
I6K98_RS18480	COG1960	acyl-CoA dehydrogenase activity
I6K98_RS18485	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6K98_RS18490	COG0704	Plays a role in the regulation of phosphate uptake
I6K98_RS18500	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6K98_RS18505	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6K98_RS18505	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6K98_RS18510	COG1643	Atp-dependent helicase
I6K98_RS18525	COG0438	transferase activity, transferring glycosyl groups
I6K98_RS18530	COG0726	polysaccharide deacetylase
I6K98_RS18535	COG0463	Glycosyl transferase, family 2
I6K98_RS18540	COG0438	transferase activity, transferring glycosyl groups
I6K98_RS18545	COG2194	sulfuric ester hydrolase activity
I6K98_RS18575	COG0859	PFAM glycosyl transferase family 9
I6K98_RS18580	COG1132	(ABC) transporter
I6K98_RS18595	COG0077	Prephenate dehydratase
I6K98_RS18600	COG1530	ribonuclease E activity
I6K98_RS18635	COG3468	outer membrane autotransporter barrel domain protein
I6K98_RS18640	COG0424	maF-like protein
I6K98_RS18645	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6K98_RS18650	COG0799	negative regulation of ribosome biogenesis
I6K98_RS18655	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6K98_RS18660	COG0408	coproporphyrinogen oxidase activity
I6K98_RS18665	COG0151	Belongs to the GarS family
I6K98_RS18670	COG0217	transcriptional regulatory protein
I6K98_RS18675	COG0433	COG0433 Predicted ATPase
I6K98_RS18680	COG1115	amino acid carrier protein
I6K98_RS18685	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K98_RS18695	COG1012	belongs to the aldehyde dehydrogenase family
I6K98_RS18720	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K98_RS18735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K98_RS18745	COG0747	negative chemotaxis
I6K98_RS18755	COG0473	3-isopropylmalate dehydrogenase activity
I6K98_RS18760	COG2814	Major facilitator Superfamily
I6K98_RS18765	COG1566	PFAM secretion protein HlyD family protein
I6K98_RS18775	COG1846	Transcriptional regulator
I6K98_RS18785	COG0697	spore germination
I6K98_RS18795	COG0501	Belongs to the peptidase M48B family
I6K98_RS18815	COG0583	DNA-binding transcription factor activity
I6K98_RS18820	COG3842	ATPase activity
I6K98_RS18825	COG1178	ABC-type Fe3 transport system permease component
I6K98_RS18830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K98_RS18835	COG1840	ABC-type Fe3 transport system, periplasmic component
I6K98_RS18860	COG2233	PERMEase
I6K98_RS18865	COG0840	transmembrane signaling receptor activity
I6K98_RS18870	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K98_RS18900	COG4789	Type iii secretion
I6K98_RS18965	COG4669	(LipO)protein
I6K98_RS19000	COG4790	Type iii secretion
I6K98_RS19005	COG4794	Type iii secretion
I6K98_RS19010	COG4791	protein targeting
I6K98_RS19015	COG4792	protein secretion
I6K98_RS19030	COG1595	DNA-templated transcription, initiation
I6K98_RS19055	COG2770	Histidine kinase
I6K98_RS19055	COG2208	phosphoserine phosphatase activity
I6K98_RS19065	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6K98_RS19070	COG2172	sigma factor antagonist activity
I6K98_RS19075	COG1366	Belongs to the anti-sigma-factor antagonist family
I6K98_RS19080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K98_RS19110	COG2358	TRAP transporter, solute receptor (TAXI family
I6K98_RS19115	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K98_RS19145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K98_RS19145	COG1017	nitric oxide dioxygenase activity
I6K98_RS19150	COG1959	2 iron, 2 sulfur cluster binding
I6K98_RS19155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K98_RS19170	COG0642	Histidine kinase
I6K98_RS19185	COG0525	valine-tRNA ligase activity
I6K98_RS19190	COG0105	UTP biosynthetic process
I6K98_RS19195	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6K98_RS19205	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6K98_RS19210	COG0124	histidyl-tRNA synthetase
I6K98_RS19215	COG2976	Protein conserved in bacteria
I6K98_RS19220	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K98_RS19225	COG1160	GTP binding
I6K98_RS19230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6K98_RS19235	COG1923	regulation of RNA biosynthetic process
I6K98_RS19240	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6K98_RS19245	COG0330	HflC and HflK could
I6K98_RS19250	COG0330	HflC and HflK could
I6K98_RS19255	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I6K98_RS19260	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6K98_RS19265	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6K98_RS19270	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6K98_RS19285	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K98_RS19310	COG0628	permease
I6K98_RS19315	COG0842	Transport permease protein
I6K98_RS19320	COG1131	(ABC) transporter
I6K98_RS19390	COG0156	8-amino-7-oxononanoate synthase activity
I6K98_RS19400	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6K98_RS19400	COG4106	trans-aconitate 2-methyltransferase activity
I6K98_RS19405	COG1380	Effector of murein hydrolase LrgA
I6K98_RS19420	COG3284	Transcriptional regulator
I6K98_RS19425	COG1012	belongs to the aldehyde dehydrogenase family
I6K98_RS19440	COG2733	membrane
I6K98_RS19445	COG0583	DNA-binding transcription factor activity
I6K98_RS19450	COG0384	phenazine biosynthesis protein PhzF
I6K98_RS19455	COG5507	3-demethylubiquinone-9 3-methyltransferase
I6K98_RS19460	COG2169	Transcriptional regulator
I6K98_RS19490	COG0659	secondary active sulfate transmembrane transporter activity
I6K98_RS19515	COG1132	(ABC) transporter
I6K98_RS19565	COG2207	Transcriptional regulator