locus-tag	class	description
LK428_RS00010	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LK428_RS00015	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LK428_RS00030	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LK428_RS00035	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LK428_RS00040	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LK428_RS00045	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LK428_RS00050	COG0649	NAD binding
LK428_RS00055	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
LK428_RS00065	COG1034	ATP synthesis coupled electron transport
LK428_RS00070	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LK428_RS00075	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LK428_RS00085	COG0713	ATP synthesis coupled electron transport
LK428_RS00100	COG1007	ATP synthesis coupled electron transport
LK428_RS00115	COG4774	siderophore transport
LK428_RS00130	COG0028	Belongs to the TPP enzyme family
LK428_RS00135	COG3181	Tripartite tricarboxylate transporter family receptor
LK428_RS00140	COG0583	DNA-binding transcription factor activity
LK428_RS00145	COG0560	Phosphoserine phosphatase
LK428_RS00150	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LK428_RS00155	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LK428_RS00160	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LK428_RS00170	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LK428_RS00175	COG0308	aminopeptidase N
LK428_RS00195	COG0165	Argininosuccinate lyase
LK428_RS00200	COG0668	transmembrane transport
LK428_RS00245	COG0747	negative chemotaxis
LK428_RS00250	COG0601	transmembrane transport
LK428_RS00255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK428_RS00260	COG1162	GTPase activity
LK428_RS00265	COG0501	Belongs to the peptidase M48B family
LK428_RS00270	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LK428_RS00280	COG3327	negative regulation of DNA-templated transcription, initiation
LK428_RS00285	COG3396	Phenylacetate-CoA oxygenase
LK428_RS00290	COG3460	Phenylacetate-CoA oxygenase
LK428_RS00295	COG3396	Phenylacetate-CoA oxygenase
LK428_RS00300	COG2151	metal-sulfur cluster biosynthetic enzyme
LK428_RS00310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LK428_RS00315	COG1012	belongs to the aldehyde dehydrogenase family
LK428_RS00320	COG1024	Enoyl-CoA hydratase
LK428_RS00325	COG2050	protein possibly involved in aromatic compounds catabolism
LK428_RS00335	COG3539	Fimbrial protein
LK428_RS00345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LK428_RS00350	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LK428_RS00350	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LK428_RS00355	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LK428_RS00360	COG0047	phosphoribosylformylglycinamidine synthase activity
LK428_RS00360	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LK428_RS00365	COG3064	Membrane
LK428_RS00365	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
LK428_RS00365	COG3210	domain, Protein
LK428_RS00380	COG0730	response to heat
LK428_RS00405	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LK428_RS00435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LK428_RS00455	COG1295	ribonuclease BN
LK428_RS00470	COG0745	RESPONSE REGULATOR receiver
LK428_RS00475	COG2205	protein histidine kinase activity
LK428_RS00490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LK428_RS00495	COG1028	Short-chain dehydrogenase reductase Sdr
LK428_RS00505	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LK428_RS00520	COG1136	(ABC) transporter
LK428_RS00525	COG0084	hydrolase, TatD family'
LK428_RS00540	COG2333	competence protein COMEC
LK428_RS00540	COG0658	competence protein
LK428_RS00550	COG0613	PHP domain protein
LK428_RS00575	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LK428_RS00580	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LK428_RS00595	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LK428_RS00600	COG3842	ATPase activity
LK428_RS00605	COG1176	ABC-type spermidine putrescine transport system, permease component I
LK428_RS00610	COG1177	transmembrane transport
LK428_RS00635	COG1960	acyl-CoA dehydrogenase activity
LK428_RS00640	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LK428_RS00645	COG0704	Plays a role in the regulation of phosphate uptake
LK428_RS00655	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LK428_RS00660	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LK428_RS00660	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LK428_RS00665	COG1643	Atp-dependent helicase
LK428_RS00680	COG0438	transferase activity, transferring glycosyl groups
LK428_RS00685	COG0726	polysaccharide deacetylase
LK428_RS00690	COG0463	Glycosyl transferase, family 2
LK428_RS00695	COG0438	transferase activity, transferring glycosyl groups
LK428_RS00700	COG2194	sulfuric ester hydrolase activity
LK428_RS00710	COG1126	abc transporter atp-binding protein
LK428_RS00715	COG0765	amino acid transport
LK428_RS00720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK428_RS00760	COG1815	bacterial-type flagellum-dependent cell motility
LK428_RS00765	COG1558	bacterial-type flagellum-dependent cell motility
LK428_RS00775	COG1749	Flagellar hook protein flgE
LK428_RS00790	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LK428_RS00795	COG1706	bacterial-type flagellum-dependent cell motility
LK428_RS00805	COG1256	bacterial-type flagellum assembly
LK428_RS00815	COG0840	transmembrane signaling receptor activity
LK428_RS00820	COG0840	transmembrane signaling receptor activity
LK428_RS00825	COG0840	transmembrane signaling receptor activity
LK428_RS00845	COG1250	3-hydroxyacyl-CoA dehydrogenase
LK428_RS00850	COG0154	amidase activity
LK428_RS00860	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LK428_RS00875	COG0495	leucyl-tRNA aminoacylation
LK428_RS00880	COG2814	Major facilitator Superfamily
LK428_RS00910	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LK428_RS00915	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LK428_RS00920	COG2814	Major facilitator Superfamily
LK428_RS00945	COG1309	transcriptional regulator
LK428_RS00950	COG1414	Transcriptional regulator
LK428_RS00955	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LK428_RS00965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LK428_RS00980	COG1028	Short-chain dehydrogenase reductase Sdr
LK428_RS00985	COG0583	DNA-binding transcription factor activity
LK428_RS00990	COG3181	Tripartite tricarboxylate transporter family receptor
LK428_RS01010	COG3181	Tripartite tricarboxylate transporter family receptor
LK428_RS01015	COG1250	3-hydroxyacyl-CoA dehydrogenase
LK428_RS01015	COG1024	Enoyl-CoA hydratase
LK428_RS01020	COG0183	Belongs to the thiolase family
LK428_RS01025	COG1454	alcohol dehydrogenase
LK428_RS01030	COG0824	Thioesterase
LK428_RS01050	COG0583	DNA-binding transcription factor activity
LK428_RS01065	COG0431	NADPH-dependent FMN reductase
LK428_RS01095	COG1028	Short-chain dehydrogenase reductase Sdr
LK428_RS01100	COG0583	DNA-binding transcription factor activity
LK428_RS01120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LK428_RS01120	COG2111	Na H antiporter
LK428_RS01125	COG1006	Multisubunit Na H antiporter MnhC subunit
LK428_RS01130	COG0651	ATP synthesis coupled electron transport
LK428_RS01135	COG1863	multisubunit Na H antiporter MnhE subunit
LK428_RS01140	COG2212	antiporter activity
LK428_RS01170	COG0590	tRNA wobble adenosine to inosine editing
LK428_RS01175	COG1619	proteins homologs of microcin C7 resistance protein MccF
LK428_RS01180	COG1024	Enoyl-CoA hydratase
LK428_RS01195	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LK428_RS01200	COG0488	(ABC) transporter
LK428_RS01235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LK428_RS01245	COG2252	PERMEase
LK428_RS01250	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LK428_RS01265	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LK428_RS01270	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LK428_RS01300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LK428_RS01305	COG0789	Transcriptional regulator
LK428_RS01315	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LK428_RS01315	COG0678	peroxiredoxin activity
LK428_RS01325	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LK428_RS01330	COG0584	glycerophosphoryl diester phosphodiesterase
LK428_RS01335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LK428_RS01345	COG4181	ATPase activity
LK428_RS01365	COG2823	Periplasmic or secreted lipoprotein
LK428_RS01375	COG3237	CsbD-like
LK428_RS01380	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LK428_RS01380	COG1181	Belongs to the D-alanine--D-alanine ligase family
LK428_RS01385	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LK428_RS01385	COG0189	ligase activity
LK428_RS01405	COG2833	Protein of unknown function (DUF455)
LK428_RS01410	COG2951	lytic endotransglycosylase activity
LK428_RS01425	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LK428_RS01440	COG0667	Aldo Keto reductase
LK428_RS01490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LK428_RS01505	COG2079	MmgE PrpD family protein
LK428_RS01510	COG1012	belongs to the aldehyde dehydrogenase family
LK428_RS01515	COG1053	succinate dehydrogenase
LK428_RS01540	COG0179	Fumarylacetoacetate (FAA) hydrolase
LK428_RS01555	COG0583	DNA-binding transcription factor activity
LK428_RS01595	COG0583	DNA-binding transcription factor activity
LK428_RS01615	COG4176	ABC-type proline glycine betaine transport system permease component
LK428_RS01625	COG1942	4-Oxalocrotonate Tautomerase
LK428_RS01630	COG0183	Belongs to the thiolase family
LK428_RS01640	COG1802	Transcriptional regulator
LK428_RS01655	COG0318	PFAM AMP-dependent synthetase and ligase
LK428_RS01665	COG2032	superoxide dismutase activity
LK428_RS01680	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LK428_RS01705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LK428_RS01710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LK428_RS01720	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LK428_RS01725	COG0736	holo-[acyl-carrier-protein] synthase activity
LK428_RS01730	COG1472	Belongs to the glycosyl hydrolase 3 family
LK428_RS01735	COG0322	excinuclease ABC activity
LK428_RS01740	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LK428_RS01750	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LK428_RS01750	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LK428_RS01755	COG2224	Isocitrate lyase
LK428_RS01770	COG0628	permease
LK428_RS01775	COG0842	Transport permease protein
LK428_RS01780	COG1131	(ABC) transporter
LK428_RS01855	COG0156	8-amino-7-oxononanoate synthase activity
LK428_RS01865	COG4106	trans-aconitate 2-methyltransferase activity
LK428_RS01865	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LK428_RS01870	COG1380	Effector of murein hydrolase LrgA
LK428_RS01875	COG1346	cytolysis
LK428_RS01905	COG0392	lysyltransferase activity
LK428_RS01910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LK428_RS01915	COG3568	Endonuclease Exonuclease Phosphatase
LK428_RS01925	COG1695	Transcriptional regulator
LK428_RS01945	COG0583	DNA-binding transcription factor activity
LK428_RS01960	COG1802	Transcriptional regulator
LK428_RS01970	COG3181	Tripartite tricarboxylate transporter family receptor
LK428_RS01980	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LK428_RS01995	COG0066	3-isopropylmalate dehydratase activity
LK428_RS02005	COG3181	Tripartite tricarboxylate transporter family receptor
LK428_RS02010	COG4948	Mandelate Racemase Muconate Lactonizing
LK428_RS02030	COG0756	dUTP diphosphatase activity
LK428_RS02040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LK428_RS02055	COG1522	sequence-specific DNA binding
LK428_RS02100	COG0540	Belongs to the ATCase OTCase family
LK428_RS02105	COG2974	May be involved in recombination
LK428_RS02115	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LK428_RS02120	COG0583	DNA-binding transcription factor activity
LK428_RS02140	COG1028	Short-chain dehydrogenase reductase Sdr
LK428_RS02155	COG3842	ATPase activity
LK428_RS02160	COG1024	Enoyl-CoA hydratase
LK428_RS02160	COG1250	3-hydroxyacyl-CoA dehydrogenase
LK428_RS02180	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LK428_RS02185	COG2137	regulation of response to DNA damage stimulus
LK428_RS02195	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LK428_RS02205	COG0045	succinate-CoA ligase (ADP-forming) activity
LK428_RS02210	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LK428_RS02215	COG0861	Integral membrane protein TerC family
LK428_RS02220	COG0861	Integral membrane protein TerC family
LK428_RS02225	COG0181	hydroxymethylbilane synthase activity
LK428_RS02280	COG4964	Belongs to the GSP D family
LK428_RS02345	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LK428_RS02355	COG2944	sequence-specific DNA binding
LK428_RS02365	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LK428_RS02370	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LK428_RS02375	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LK428_RS02380	COG0009	L-threonylcarbamoyladenylate synthase
LK428_RS02385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK428_RS02390	COG1414	Transcriptional regulator
LK428_RS02405	COG0765	amino acid transport
LK428_RS02410	COG1126	abc transporter atp-binding protein
LK428_RS02415	COG0028	Belongs to the TPP enzyme family
LK428_RS02430	COG0028	Belongs to the TPP enzyme family
LK428_RS02435	COG0583	DNA-binding transcription factor activity
LK428_RS02440	COG4974	Belongs to the 'phage' integrase family
LK428_RS02445	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LK428_RS02450	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
LK428_RS02460	COG1686	Belongs to the peptidase S11 family
LK428_RS02470	COG2814	Major facilitator Superfamily
LK428_RS02485	COG1074	ATP-dependent DNA helicase activity
LK428_RS02495	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LK428_RS02500	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LK428_RS02505	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LK428_RS02535	COG0765	amino acid transport
LK428_RS02540	COG0765	amino acid transport
LK428_RS02545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK428_RS02580	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LK428_RS02585	COG1595	DNA-templated transcription, initiation
LK428_RS02595	COG3530	Putative quorum-sensing-regulated virulence factor
LK428_RS02600	COG0494	nUDIX hydrolase
LK428_RS02615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LK428_RS02620	COG0542	response to heat
LK428_RS02650	COG4336	lyase activity
LK428_RS02660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK428_RS02660	COG2205	protein histidine kinase activity
LK428_RS02665	COG2197	response regulator
LK428_RS02670	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
LK428_RS02670	COG3210	domain, Protein
LK428_RS02670	COG3064	Membrane
LK428_RS02680	COG3121	Chaperone
LK428_RS02685	COG3188	usher protein
LK428_RS02690	COG3539	Fimbrial protein
LK428_RS02695	COG2831	hemolysin activation secretion protein
LK428_RS02710	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LK428_RS02735	COG0583	DNA-binding transcription factor activity
LK428_RS02760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK428_RS02765	COG0765	amino acid transport
LK428_RS02770	COG1126	abc transporter atp-binding protein
LK428_RS02775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LK428_RS02780	COG1758	RNA polymerase activity
LK428_RS02785	COG0194	GDP metabolic process
LK428_RS02790	COG3258	Cytochrome c
LK428_RS02795	COG2863	cytochrome
LK428_RS02800	COG1028	Short-chain dehydrogenase reductase Sdr
LK428_RS02805	COG0791	NLP P60 protein
LK428_RS02825	COG1561	YicC-like family, N-terminal region
LK428_RS02830	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LK428_RS02850	COG2199	diguanylate cyclase activity
LK428_RS02850	COG2200	EAL domain
LK428_RS02855	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LK428_RS02865	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LK428_RS02870	COG0174	glutamine synthetase
LK428_RS02880	COG2204	response regulator
LK428_RS02885	COG0583	DNA-binding transcription factor activity
LK428_RS02890	COG1741	Belongs to the pirin family
LK428_RS02895	COG1741	Belongs to the pirin family
LK428_RS02900	COG3842	ATPase activity
LK428_RS02905	COG1178	ABC-type Fe3 transport system permease component
LK428_RS02910	COG1840	ABC-type Fe3 transport system, periplasmic component
LK428_RS02920	COG0583	DNA-binding transcription factor activity
LK428_RS02930	COG0656	L-ascorbic acid biosynthetic process
LK428_RS02945	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LK428_RS02950	COG0583	DNA-binding transcription factor activity
LK428_RS02965	COG0783	Belongs to the Dps family
LK428_RS02980	COG0463	Glycosyl transferase, family 2
LK428_RS03000	COG0438	transferase activity, transferring glycosyl groups
LK428_RS03020	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LK428_RS03040	COG4221	oxidoreductase activity
LK428_RS03065	COG3842	ATPase activity
LK428_RS03070	COG0395	ABC-type sugar transport system, permease component
LK428_RS03075	COG1175	transmembrane transport
LK428_RS03080	COG1653	transport
LK428_RS03090	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LK428_RS03100	COG0559	Belongs to the binding-protein-dependent transport system permease family
LK428_RS03135	COG0697	spore germination
LK428_RS03150	COG2363	Small membrane protein
LK428_RS03165	COG1464	Belongs to the NlpA lipoprotein family
LK428_RS03175	COG0688	phosphatidylethanolamine metabolic process
LK428_RS03190	COG0095	Lipoate-protein ligase
LK428_RS03205	COG0625	glutathione transferase activity
LK428_RS03210	COG0386	Belongs to the glutathione peroxidase family
LK428_RS03250	COG0228	four-way junction DNA binding
LK428_RS03255	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LK428_RS03260	COG0336	Belongs to the RNA methyltransferase TrmD family
LK428_RS03265	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LK428_RS03280	COG0642	Histidine kinase
LK428_RS03295	COG0525	valine-tRNA ligase activity
LK428_RS03300	COG0105	UTP biosynthetic process
LK428_RS03305	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LK428_RS03315	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LK428_RS03320	COG0124	histidyl-tRNA synthetase
LK428_RS03325	COG2976	Protein conserved in bacteria
LK428_RS03330	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LK428_RS03335	COG1160	GTP binding
LK428_RS03340	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LK428_RS03345	COG1923	regulation of RNA biosynthetic process
LK428_RS03350	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LK428_RS03355	COG0330	HflC and HflK could
LK428_RS03360	COG0330	HflC and HflK could
LK428_RS03365	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
LK428_RS03370	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LK428_RS03375	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LK428_RS03380	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LK428_RS03395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LK428_RS03425	COG0559	Belongs to the binding-protein-dependent transport system permease family
LK428_RS03435	COG4638	Rieske (2fe-2S)
LK428_RS03445	COG1024	Enoyl-CoA hydratase
LK428_RS03455	COG0633	Ferredoxin
LK428_RS03460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LK428_RS03475	COG0183	Belongs to the thiolase family
LK428_RS03485	COG4692	amylo-alpha-1,6-glucosidase activity
LK428_RS03525	COG0425	Belongs to the sulfur carrier protein TusA family
LK428_RS03530	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LK428_RS03585	COG4172	Belongs to the ABC transporter superfamily
LK428_RS03590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK428_RS03595	COG0601	transmembrane transport
LK428_RS03600	COG0747	negative chemotaxis
LK428_RS03625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LK428_RS03635	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LK428_RS03650	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LK428_RS03655	COG3395	kinase activity
LK428_RS03670	COG1024	Enoyl-CoA hydratase
LK428_RS03685	COG0633	Ferredoxin
LK428_RS03690	COG0443	Heat shock 70 kDa protein
LK428_RS03695	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LK428_RS03700	COG0316	Belongs to the HesB IscA family
LK428_RS03705	COG0822	iron-sulfur transferase activity
LK428_RS03710	COG1104	cysteine desulfurase activity
LK428_RS03720	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LK428_RS03725	COG0556	nucleotide-excision repair
LK428_RS03735	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LK428_RS03770	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LK428_RS03795	COG1028	Short-chain dehydrogenase reductase Sdr
LK428_RS03800	COG0183	Belongs to the thiolase family
LK428_RS03810	COG1024	Enoyl-CoA hydratase
LK428_RS03825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LK428_RS03830	COG0583	DNA-binding transcription factor activity
LK428_RS03835	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LK428_RS03840	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LK428_RS03845	COG0740	serine-type endopeptidase activity
LK428_RS03850	COG0544	peptidyl-prolyl cis-trans isomerase activity
LK428_RS03860	COG1278	Cold shock
LK428_RS03875	COG1278	Cold shock
LK428_RS03905	COG0436	Aminotransferase
LK428_RS03910	COG2171	N-acyltransferase activity
LK428_RS03915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LK428_RS03920	COG2890	protein-(glutamine-N5) methyltransferase activity
LK428_RS03925	COG0488	(ABC) transporter
LK428_RS03930	COG4771	TonB-dependent receptor
LK428_RS03935	COG0210	DNA helicase
LK428_RS03955	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LK428_RS03960	COG0196	riboflavin kinase activity
LK428_RS03965	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LK428_RS03970	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LK428_RS03975	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LK428_RS03985	COG1522	sequence-specific DNA binding
LK428_RS04000	COG3119	arylsulfatase activity
LK428_RS04035	COG0714	Associated with various cellular activities
LK428_RS04055	COG1028	Short-chain dehydrogenase reductase Sdr
LK428_RS04060	COG0861	Integral membrane protein TerC family
LK428_RS04125	COG0672	)-iron permease
LK428_RS04140	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
LK428_RS04145	COG1028	Short-chain dehydrogenase reductase Sdr
LK428_RS04150	COG3243	poly(R)-hydroxyalkanoic acid synthase
LK428_RS04160	COG0564	pseudouridine synthase activity
LK428_RS04170	COG1199	ATP-dependent helicase activity
LK428_RS04175	COG2183	response to ionizing radiation
LK428_RS04185	COG0180	Tryptophanyl-tRNA synthetase
LK428_RS04210	COG4774	siderophore transport
LK428_RS04215	COG3712	iron ion homeostasis
LK428_RS04220	COG1595	DNA-templated transcription, initiation
LK428_RS04235	COG3181	Tripartite tricarboxylate transporter family receptor
LK428_RS04245	COG0583	DNA-binding transcription factor activity
LK428_RS04250	COG1028	Short-chain dehydrogenase reductase Sdr
LK428_RS04255	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LK428_RS04260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LK428_RS04265	COG0508	dehydrogenase complex catalyzes the overall conversion of
LK428_RS04270	COG0567	Dehydrogenase, E1 component
LK428_RS04285	COG1522	sequence-specific DNA binding
LK428_RS04295	COG0280	phosphate acetyltransferase
LK428_RS04295	COG0281	malic enzyme
LK428_RS04300	COG3539	Fimbrial protein
LK428_RS04310	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LK428_RS04325	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LK428_RS04330	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LK428_RS04335	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LK428_RS04345	COG0745	RESPONSE REGULATOR receiver
LK428_RS04385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LK428_RS04405	COG0612	Peptidase, M16
LK428_RS04410	COG0484	heat shock protein binding
LK428_RS04415	COG0443	Heat shock 70 kDa protein
LK428_RS04425	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LK428_RS04435	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LK428_RS04440	COG1420	regulation of RNA biosynthetic process
LK428_RS04445	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LK428_RS04450	COG0497	DNA recombination
LK428_RS04455	COG0735	belongs to the Fur family
LK428_RS04460	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LK428_RS04465	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LK428_RS04470	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LK428_RS04505	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LK428_RS04505	COG0446	pyridine nucleotide-disulphide oxidoreductase
LK428_RS04510	COG4311	Sarcosine oxidase, delta subunit
LK428_RS04515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LK428_RS04525	COG0583	DNA-binding transcription factor activity
LK428_RS04535	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LK428_RS04550	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LK428_RS04555	COG2030	dehydratase
LK428_RS04565	COG1024	Enoyl-CoA hydratase
LK428_RS04595	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LK428_RS04620	COG0248	Ppx GppA phosphatase
LK428_RS04630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LK428_RS04640	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LK428_RS04650	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LK428_RS04655	COG1534	Rna-binding protein
LK428_RS04665	COG3971	2-oxopent-4-enoate hydratase activity
LK428_RS04695	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LK428_RS04700	COG0045	succinate-CoA ligase (ADP-forming) activity
LK428_RS04700	COG1042	CoA-binding domain protein
LK428_RS04700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LK428_RS04710	COG0511	ligase activity, forming carbon-carbon bonds
LK428_RS04715	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LK428_RS04725	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LK428_RS04730	COG0439	Biotin carboxylase
LK428_RS04735	COG2188	Transcriptional regulator
LK428_RS04760	COG0511	ligase activity, forming carbon-carbon bonds
LK428_RS04770	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LK428_RS04775	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LK428_RS04795	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
LK428_RS04815	COG0500	methyltransferase
LK428_RS04820	COG5265	(ABC) transporter
LK428_RS04830	COG0789	Transcriptional regulator
LK428_RS04845	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LK428_RS04850	COG0745	RESPONSE REGULATOR receiver
LK428_RS04855	COG2201	protein-glutamate methylesterase activity
LK428_RS04865	COG0840	transmembrane signaling receptor activity
LK428_RS04880	COG0745	RESPONSE REGULATOR receiver
LK428_RS04940	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LK428_RS04950	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LK428_RS04970	COG1640	4-alpha-glucanotransferase
LK428_RS04985	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LK428_RS05015	COG0667	Aldo Keto reductase
LK428_RS05030	COG2259	Doxx family
LK428_RS05055	COG2346	COG2346, Truncated hemoglobins
LK428_RS05180	COG2207	Transcriptional regulator
LK428_RS05225	COG1132	(ABC) transporter
LK428_RS05280	COG2169	Transcriptional regulator
LK428_RS05285	COG5507	3-demethylubiquinone-9 3-methyltransferase
LK428_RS05290	COG0384	phenazine biosynthesis protein PhzF
LK428_RS05295	COG0583	DNA-binding transcription factor activity
LK428_RS05300	COG2733	membrane
LK428_RS05315	COG1012	belongs to the aldehyde dehydrogenase family
LK428_RS05320	COG3284	Transcriptional regulator
LK428_RS05330	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LK428_RS05340	COG0739	heme binding
LK428_RS05350	COG0521	Mo-molybdopterin cofactor biosynthetic process
LK428_RS05355	COG0306	phosphate transporter
LK428_RS05400	COG0625	glutathione transferase activity
LK428_RS05415	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LK428_RS05420	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LK428_RS05425	COG0126	phosphoglycerate kinase activity
LK428_RS05430	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LK428_RS05435	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LK428_RS05440	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LK428_RS05450	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LK428_RS05455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LK428_RS05460	COG0508	dehydrogenase complex catalyzes the overall conversion of
LK428_RS05465	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LK428_RS05475	COG4566	intracellular signal transduction
LK428_RS05480	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LK428_RS05485	COG0339	signal peptide processing
LK428_RS05490	COG1999	signal sequence binding
LK428_RS05520	COG1187	pseudouridine synthase activity
LK428_RS05525	COG3161	chorismate lyase activity
LK428_RS05540	COG0667	Aldo Keto reductase
LK428_RS05555	COG0335	large ribosomal subunit rRNA binding
LK428_RS05610	COG0450	alkyl hydroperoxide reductase
LK428_RS05615	COG1960	acyl-CoA dehydrogenase activity
LK428_RS05630	COG0123	including yeast histone deacetylase and acetoin utilization protein
LK428_RS05635	COG2951	lytic endotransglycosylase activity
LK428_RS05650	COG1555	photosystem II stabilization
LK428_RS05650	COG1596	polysaccharide export
LK428_RS05655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LK428_RS05660	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LK428_RS05665	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LK428_RS05685	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LK428_RS05690	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LK428_RS05695	COG0287	Prephenate dehydrogenase
LK428_RS05705	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LK428_RS05725	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LK428_RS05735	COG2814	Major facilitator Superfamily
LK428_RS05755	COG1902	pentaerythritol trinitrate reductase activity
LK428_RS05765	COG0583	DNA-binding transcription factor activity
LK428_RS05810	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LK428_RS05820	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LK428_RS05820	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LK428_RS05830	COG0028	Belongs to the TPP enzyme family
LK428_RS05845	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LK428_RS05855	COG1126	abc transporter atp-binding protein
LK428_RS05865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK428_RS05880	COG0084	hydrolase, TatD family'
LK428_RS05890	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LK428_RS05895	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LK428_RS05915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LK428_RS05915	COG1017	nitric oxide dioxygenase activity
LK428_RS05920	COG1959	2 iron, 2 sulfur cluster binding
LK428_RS05925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LK428_RS05955	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LK428_RS05960	COG2358	TRAP transporter, solute receptor (TAXI family
LK428_RS05975	COG2311	Membrane
LK428_RS06000	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LK428_RS06010	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LK428_RS06015	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LK428_RS06020	COG1760	l-serine dehydratase
LK428_RS06025	COG1283	sodium-dependent phosphate transmembrane transporter activity
LK428_RS06030	COG0412	Dienelactone hydrolase
LK428_RS06045	COG1611	Belongs to the LOG family
LK428_RS06065	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LK428_RS06070	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LK428_RS06075	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LK428_RS06080	COG0195	Participates in both transcription termination and antitermination
LK428_RS06080	COG2251	uridine kinase activity
LK428_RS06085	COG0779	Required for maturation of 30S ribosomal subunits
LK428_RS06090	COG1187	pseudouridine synthase activity
LK428_RS06095	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LK428_RS06105	COG0583	DNA-binding transcription factor activity
LK428_RS06115	COG0523	cobalamin synthesis protein
LK428_RS06135	COG0625	glutathione transferase activity
LK428_RS06140	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LK428_RS06145	COG1047	Peptidyl-prolyl cis-trans
LK428_RS06150	COG2003	Belongs to the UPF0758 family
LK428_RS06155	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
LK428_RS06160	COG3483	tryptophan 2,3-dioxygenase activity
LK428_RS06165	COG0254	rRNA binding
LK428_RS06175	COG0534	Mate efflux family protein
LK428_RS06195	COG2304	oxidoreductase activity
LK428_RS06210	COG1028	Short-chain dehydrogenase reductase Sdr
LK428_RS06215	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LK428_RS06220	COG1562	ergosterol biosynthetic process
LK428_RS06225	COG1562	ergosterol biosynthetic process
LK428_RS06230	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
LK428_RS06230	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
LK428_RS06235	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LK428_RS06245	COG0842	Transport permease protein
LK428_RS06250	COG1131	(ABC) transporter
LK428_RS06270	COG1477	protein flavinylation
LK428_RS06285	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LK428_RS06300	COG5564	TIM-barrel signal transduction protein
LK428_RS06305	COG5441	Belongs to the UPF0261 family
LK428_RS06320	COG3468	outer membrane autotransporter barrel domain protein
LK428_RS06330	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LK428_RS06340	COG2197	response regulator
LK428_RS06345	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LK428_RS06350	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LK428_RS06355	COG0189	ligase activity
LK428_RS06365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LK428_RS06370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LK428_RS06385	COG2423	ornithine cyclodeaminase activity
LK428_RS06395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK428_RS06400	COG0765	amino acid transport
LK428_RS06405	COG0765	amino acid transport
LK428_RS06410	COG1126	abc transporter atp-binding protein
LK428_RS06425	COG0135	phosphoribosylanthranilate isomerase activity
LK428_RS06440	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LK428_RS06445	COG0101	tRNA pseudouridine synthase activity
LK428_RS06455	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LK428_RS06460	COG0473	3-isopropylmalate dehydrogenase activity
LK428_RS06465	COG0066	3-isopropylmalate dehydratase activity
LK428_RS06470	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LK428_RS06480	COG1122	ATPase activity
LK428_RS06515	COG0243	molybdopterin cofactor binding
LK428_RS06515	COG3383	formate dehydrogenase (NAD+) activity
LK428_RS06545	COG0489	protein tyrosine kinase activity
LK428_RS06550	COG0746	molybdenum cofactor guanylyltransferase activity
LK428_RS06555	COG0303	'Molybdopterin
LK428_RS06560	COG1763	Mo-molybdopterin cofactor biosynthetic process
LK428_RS06570	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LK428_RS06575	COG5001	Diguanylate cyclase
LK428_RS06600	COG3842	ATPase activity
LK428_RS06610	COG0406	alpha-ribazole phosphatase activity
LK428_RS06620	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LK428_RS06625	COG0505	Belongs to the CarA family
LK428_RS06630	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LK428_RS06655	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LK428_RS06660	COG1960	acyl-CoA dehydrogenase activity
LK428_RS06670	COG2867	negative regulation of translational initiation
LK428_RS06675	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LK428_RS06680	COG3706	GGDEF domain
LK428_RS06685	COG0330	HflC and HflK could
LK428_RS06700	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LK428_RS06700	COG0519	Catalyzes the synthesis of GMP from XMP
LK428_RS06710	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LK428_RS06715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LK428_RS06720	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LK428_RS06725	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LK428_RS06735	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LK428_RS06740	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LK428_RS06745	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
LK428_RS06750	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LK428_RS06755	COG0750	zinc metalloprotease
LK428_RS06760	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LK428_RS06770	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LK428_RS06775	COG0233	cytoplasmic translational termination
LK428_RS06780	COG0528	UMP kinase activity
LK428_RS06785	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LK428_RS06790	COG0052	Belongs to the universal ribosomal protein uS2 family
LK428_RS06795	COG0024	Methionine aminopeptidase
LK428_RS06800	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LK428_RS06830	COG0285	dihydrofolate synthase activity
LK428_RS06865	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LK428_RS06875	COG1677	Flagellar hook-basal body complex protein FliE
LK428_RS06885	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LK428_RS06895	COG1157	protein secretion by the type III secretion system
LK428_RS06910	COG1580	Controls the rotational direction of flagella during chemotaxis
LK428_RS06930	COG1338	Plays a role in the flagellum-specific transport system
LK428_RS06990	COG0427	acetyl-CoA hydrolase
LK428_RS06995	COG0583	DNA-binding transcription factor activity
LK428_RS07005	COG1511	domain protein
LK428_RS07005	COG3264	Mechanosensitive ion channel
LK428_RS07025	COG0730	response to heat
LK428_RS07030	COG0697	spore germination
LK428_RS07065	COG2885	chlorophyll binding
LK428_RS07090	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LK428_RS07095	COG3384	dioxygenase
LK428_RS07110	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LK428_RS07115	COG3474	cytochrome
LK428_RS07125	COG1595	DNA-templated transcription, initiation
LK428_RS07140	COG2204	response regulator
LK428_RS07180	COG4964	Belongs to the GSP D family
LK428_RS07225	COG1846	Transcriptional regulator
LK428_RS07230	COG4172	Belongs to the ABC transporter superfamily
LK428_RS07235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK428_RS07240	COG0601	transmembrane transport
LK428_RS07245	COG0747	negative chemotaxis
LK428_RS07255	COG0598	Magnesium transport protein CorA
LK428_RS07260	COG0210	DNA helicase
LK428_RS07275	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LK428_RS07280	COG1012	belongs to the aldehyde dehydrogenase family
LK428_RS07285	COG0483	inositol monophosphate 1-phosphatase activity
LK428_RS07295	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LK428_RS07305	COG1045	serine acetyltransferase
LK428_RS07310	COG0166	Belongs to the GPI family
LK428_RS07325	COG2197	response regulator
LK428_RS07340	COG0183	Belongs to the thiolase family
LK428_RS07355	COG1250	3-hydroxyacyl-CoA dehydrogenase
LK428_RS07355	COG1024	Enoyl-CoA hydratase
LK428_RS07360	COG0183	Belongs to the thiolase family
LK428_RS07400	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LK428_RS07400	COG2010	Cytochrome c
LK428_RS07410	COG2080	2 iron, 2 sulfur cluster binding
LK428_RS07415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LK428_RS07420	COG3473	Maleate cis-trans isomerase
LK428_RS07430	COG2309	aminopeptidase activity
LK428_RS07435	COG1335	isochorismatase
LK428_RS07450	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LK428_RS07450	COG1017	nitric oxide dioxygenase activity
LK428_RS07465	COG3181	Tripartite tricarboxylate transporter family receptor
LK428_RS07490	COG1846	Transcriptional regulator
LK428_RS07510	COG0726	polysaccharide deacetylase
LK428_RS07510	COG1649	PFAM Uncharacterised BCR, COG1649
LK428_RS07515	COG1215	transferase activity, transferring glycosyl groups
LK428_RS07525	COG1902	pentaerythritol trinitrate reductase activity
LK428_RS07550	COG0251	oxidation-reduction process
LK428_RS07560	COG1832	CoA-binding protein
LK428_RS07565	COG1414	Transcriptional regulator
LK428_RS07570	COG1902	pentaerythritol trinitrate reductase activity
LK428_RS07570	COG0446	pyridine nucleotide-disulphide oxidoreductase
LK428_RS07580	COG3842	ATPase activity
LK428_RS07605	COG0583	DNA-binding transcription factor activity
LK428_RS07615	COG1028	Short-chain dehydrogenase reductase Sdr
LK428_RS07620	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
LK428_RS07625	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LK428_RS07640	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LK428_RS07640	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LK428_RS07645	COG1250	3-hydroxyacyl-CoA dehydrogenase
LK428_RS07670	COG0527	aspartate kinase activity
LK428_RS07675	COG0037	tRNA processing
LK428_RS07685	COG0825	malonyl-CoA metabolic process
LK428_RS07695	COG0215	cysteine-tRNA ligase activity
LK428_RS07710	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LK428_RS07715	COG1968	undecaprenyl-diphosphatase activity
LK428_RS07720	COG1253	flavin adenine dinucleotide binding
LK428_RS07725	COG0483	inositol monophosphate 1-phosphatase activity
LK428_RS07745	COG0668	transmembrane transport
LK428_RS07755	COG1053	succinate dehydrogenase
LK428_RS07760	COG0583	DNA-binding transcription factor activity
LK428_RS07775	COG1053	succinate dehydrogenase
LK428_RS07795	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LK428_RS07800	COG0459	protein refolding
LK428_RS07805	COG3468	outer membrane autotransporter barrel domain protein
LK428_RS07820	COG1252	NADH dehydrogenase
LK428_RS07825	COG0284	orotidine-5'-phosphate decarboxylase activity
LK428_RS07830	COG1058	Belongs to the CinA family
LK428_RS07830	COG1546	Belongs to the CinA family
LK428_RS07835	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LK428_RS07845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LK428_RS07850	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LK428_RS07875	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LK428_RS07880	COG3639	organic phosphonate transmembrane transporter activity
LK428_RS07885	COG3639	organic phosphonate transmembrane transporter activity
LK428_RS07905	COG0742	ribosomal rna small subunit methyltransferase
LK428_RS07910	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LK428_RS07915	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LK428_RS07920	COG3135	benzoate transporter
LK428_RS07935	COG0640	Transcriptional regulator
LK428_RS07950	COG0583	DNA-binding transcription factor activity
LK428_RS07965	COG0747	negative chemotaxis
LK428_RS07970	COG4172	Belongs to the ABC transporter superfamily
LK428_RS07975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK428_RS07980	COG0601	transmembrane transport
LK428_RS07990	COG0281	malic enzyme
LK428_RS07990	COG0280	phosphate acetyltransferase
LK428_RS08040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LK428_RS08045	COG1366	Belongs to the anti-sigma-factor antagonist family
LK428_RS08050	COG2172	sigma factor antagonist activity
LK428_RS08055	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LK428_RS08075	COG2208	phosphoserine phosphatase activity
LK428_RS08075	COG2770	Histidine kinase
LK428_RS08100	COG1595	DNA-templated transcription, initiation
LK428_RS08115	COG4792	protein secretion
LK428_RS08120	COG4791	protein targeting
LK428_RS08125	COG4794	Type iii secretion
LK428_RS08130	COG4790	Type iii secretion
LK428_RS08165	COG4669	(LipO)protein
LK428_RS08230	COG4789	Type iii secretion
LK428_RS08275	COG2233	PERMEase
LK428_RS08280	COG0840	transmembrane signaling receptor activity
LK428_RS08285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LK428_RS08300	COG1840	ABC-type Fe3 transport system, periplasmic component
LK428_RS08305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LK428_RS08310	COG1178	ABC-type Fe3 transport system permease component
LK428_RS08315	COG3842	ATPase activity
LK428_RS08320	COG0583	DNA-binding transcription factor activity
LK428_RS08340	COG0501	Belongs to the peptidase M48B family
LK428_RS08350	COG0697	spore germination
LK428_RS08360	COG1846	Transcriptional regulator
LK428_RS08380	COG1566	PFAM secretion protein HlyD family protein
LK428_RS08385	COG2814	Major facilitator Superfamily
LK428_RS08390	COG0473	3-isopropylmalate dehydrogenase activity
LK428_RS08400	COG0747	negative chemotaxis
LK428_RS08410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK428_RS08430	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LK428_RS08455	COG1012	belongs to the aldehyde dehydrogenase family
LK428_RS08465	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LK428_RS08470	COG1115	amino acid carrier protein
LK428_RS08475	COG0433	COG0433 Predicted ATPase
LK428_RS08480	COG0217	transcriptional regulatory protein
LK428_RS08485	COG0151	Belongs to the GarS family
LK428_RS08490	COG0408	coproporphyrinogen oxidase activity
LK428_RS08495	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LK428_RS08500	COG0799	negative regulation of ribosome biogenesis
LK428_RS08505	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LK428_RS08510	COG0424	maF-like protein
LK428_RS08515	COG3468	outer membrane autotransporter barrel domain protein
LK428_RS08550	COG1530	ribonuclease E activity
LK428_RS08555	COG0077	Prephenate dehydratase
LK428_RS08575	COG0859	PFAM glycosyl transferase family 9
LK428_RS08625	COG0671	phosphoesterase, PA-phosphatase related
LK428_RS08635	COG1597	lipid kinase activity
LK428_RS08645	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LK428_RS08655	COG1733	regulation of RNA biosynthetic process
LK428_RS08660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LK428_RS08665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LK428_RS08680	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
LK428_RS08700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LK428_RS08720	COG3608	succinylglutamate desuccinylase aspartoacylase
LK428_RS08725	COG0626	cystathionine gamma-synthase activity
LK428_RS08730	COG0583	DNA-binding transcription factor activity
LK428_RS08750	COG0165	Argininosuccinate lyase
LK428_RS08765	COG3799	methylaspartate ammonia-lyase activity
LK428_RS08775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LK428_RS08785	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LK428_RS08790	COG0149	triose-phosphate isomerase activity
LK428_RS08810	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LK428_RS08825	COG1028	Short-chain dehydrogenase reductase Sdr
LK428_RS08835	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LK428_RS08840	COG1845	cytochrome c oxidase, subunit III
LK428_RS08845	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LK428_RS08855	COG0477	Major facilitator Superfamily
LK428_RS08895	COG1309	transcriptional regulator
LK428_RS08900	COG2271	Major facilitator Superfamily
LK428_RS08940	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LK428_RS08940	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LK428_RS08940	COG0506	proline dehydrogenase activity
LK428_RS08950	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LK428_RS08950	COG3008	intermembrane lipid transfer
LK428_RS08955	COG2995	paraquat-inducible protein a
LK428_RS08960	COG0542	response to heat
LK428_RS08965	COG4953	penicillin-binding protein 1C
LK428_RS08975	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LK428_RS08980	COG1278	Cold shock
LK428_RS08990	COG0183	Belongs to the thiolase family
LK428_RS08995	COG0038	chloride channel
LK428_RS09000	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LK428_RS09005	COG1570	exodeoxyribonuclease VII activity
LK428_RS09025	COG0268	Binds directly to 16S ribosomal RNA
LK428_RS09035	COG0728	peptidoglycan biosynthetic process
LK428_RS09045	COG0563	adenylate kinase activity
LK428_RS09050	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LK428_RS09055	COG2835	tetraacyldisaccharide 4'-kinase activity
LK428_RS09060	COG1663	tetraacyldisaccharide 4'-kinase activity
LK428_RS09065	COG0848	biopolymer transport protein
LK428_RS09070	COG0811	peptide transport
LK428_RS09090	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
LK428_RS09120	COG0436	Aminotransferase
LK428_RS09125	COG3737	Protein of unknown function (DUF498/DUF598)
LK428_RS09130	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LK428_RS09135	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LK428_RS09140	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LK428_RS09150	COG0305	Participates in initiation and elongation during chromosome replication
LK428_RS09160	COG0359	binds to the 23S rRNA
LK428_RS09165	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LK428_RS09170	COG2965	DNA replication, synthesis of RNA primer
LK428_RS09175	COG0360	Binds together with S18 to 16S ribosomal RNA
LK428_RS09180	COG1469	GTP cyclohydrolase I activity
LK428_RS09185	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LK428_RS09190	COG0142	geranyltranstransferase activity
LK428_RS09195	COG1722	exodeoxyribonuclease VII activity
LK428_RS09205	COG3181	Tripartite tricarboxylate transporter family receptor
LK428_RS09240	COG1304	FMN binding
LK428_RS09255	COG0154	amidase activity
LK428_RS09260	COG1414	Transcriptional regulator
LK428_RS09275	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LK428_RS09280	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LK428_RS09285	COG0594	ribonuclease P activity
LK428_RS09290	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LK428_RS09295	COG0706	membrane insertase activity
LK428_RS09315	COG0583	DNA-binding transcription factor activity
LK428_RS09325	COG2188	Transcriptional regulator
LK428_RS09355	COG0829	nickel cation binding
LK428_RS09360	COG0831	urea catabolic process
LK428_RS09370	COG0832	Belongs to the urease beta subunit family
LK428_RS09375	COG0804	urea catabolic process
LK428_RS09390	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LK428_RS09410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LK428_RS09415	COG0405	Gamma-glutamyltransferase
LK428_RS09425	COG3181	Tripartite tricarboxylate transporter family receptor
LK428_RS09435	COG0114	fumarate hydratase activity
LK428_RS09440	COG0802	atpase or kinase
LK428_RS09445	COG0860	N-Acetylmuramoyl-L-alanine amidase
LK428_RS09450	COG0586	Pfam SNARE associated Golgi protein
LK428_RS09455	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LK428_RS09460	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LK428_RS09465	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LK428_RS09480	COG0617	tRNA 3'-terminal CCA addition
LK428_RS09505	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LK428_RS09510	COG2188	Transcriptional regulator
LK428_RS09525	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LK428_RS09535	COG1028	Short-chain dehydrogenase reductase Sdr
LK428_RS09555	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LK428_RS09560	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LK428_RS09565	COG1012	belongs to the aldehyde dehydrogenase family
LK428_RS09600	COG1294	oxidase, subunit
LK428_RS09610	COG4988	ABC transporter
LK428_RS09615	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LK428_RS09620	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LK428_RS09650	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LK428_RS09665	COG1802	Transcriptional regulator
LK428_RS09680	COG1024	Enoyl-CoA hydratase
LK428_RS09690	COG3181	Tripartite tricarboxylate transporter family receptor
LK428_RS09710	COG1984	allophanate hydrolase subunit 2
LK428_RS09715	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LK428_RS09725	COG0583	DNA-binding transcription factor activity
LK428_RS09730	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LK428_RS09740	COG5002	protein histidine kinase activity
LK428_RS09750	COG5002	protein histidine kinase activity
LK428_RS09755	COG0745	RESPONSE REGULATOR receiver
LK428_RS09760	COG2226	methyltransferase
LK428_RS09775	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LK428_RS09800	COG0583	DNA-binding transcription factor activity
LK428_RS09810	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LK428_RS09820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LK428_RS09825	COG0154	amidase activity
LK428_RS09835	COG1609	Transcriptional regulator
LK428_RS09855	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LK428_RS09865	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LK428_RS09875	COG0628	permease
LK428_RS09885	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LK428_RS09895	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LK428_RS09900	COG0351	phosphomethylpyrimidine kinase
LK428_RS09905	COG2022	thiamine diphosphate biosynthetic process
LK428_RS09910	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LK428_RS09915	COG4206	TonB-dependent receptor
LK428_RS09960	COG0154	amidase activity
LK428_RS09970	COG1414	Transcriptional regulator
LK428_RS09980	COG1250	3-hydroxyacyl-CoA dehydrogenase
LK428_RS09980	COG1024	Enoyl-CoA hydratase
LK428_RS09990	COG2132	Multicopper oxidase
LK428_RS10015	COG1538	Outer membrane efflux protein
LK428_RS10020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LK428_RS10030	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
LK428_RS10040	COG2994	toxin metabolic process
LK428_RS10055	COG1137	ATPase activity
LK428_RS10070	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LK428_RS10080	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LK428_RS10115	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LK428_RS10120	COG3568	Endonuclease Exonuclease Phosphatase
LK428_RS10125	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LK428_RS10165	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LK428_RS10175	COG3781	membrane
LK428_RS10180	COG1522	sequence-specific DNA binding
LK428_RS10185	COG0028	Belongs to the TPP enzyme family
LK428_RS10195	COG1012	belongs to the aldehyde dehydrogenase family
LK428_RS10200	COG1028	Short-chain dehydrogenase reductase Sdr
LK428_RS10205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LK428_RS10230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LK428_RS10235	COG2922	Belongs to the Smg family
LK428_RS10240	COG1629	transport
LK428_RS10250	COG2358	TRAP transporter, solute receptor (TAXI family
LK428_RS10260	COG3181	Tripartite tricarboxylate transporter family receptor
LK428_RS10265	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LK428_RS10280	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LK428_RS10290	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
LK428_RS10305	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
LK428_RS10310	COG4569	acetaldehyde dehydrogenase (acetylating) activity
LK428_RS10315	COG0583	DNA-binding transcription factor activity
LK428_RS10320	COG2814	Major facilitator Superfamily
LK428_RS10325	COG0129	dihydroxy-acid dehydratase activity
LK428_RS10330	COG2207	Transcriptional regulator
LK428_RS10335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LK428_RS10345	COG0657	acetylesterase activity
LK428_RS10350	COG0747	negative chemotaxis
LK428_RS10355	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LK428_RS10360	COG2808	Putative FMN-binding domain
LK428_RS10370	COG4257	antibiotic catabolic process
LK428_RS10380	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LK428_RS10395	COG1250	3-hydroxyacyl-CoA dehydrogenase
LK428_RS10400	COG2031	fatty acid transporter
LK428_RS10405	COG1028	Short-chain dehydrogenase reductase Sdr
LK428_RS10410	COG1414	Transcriptional regulator
LK428_RS10420	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LK428_RS10435	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LK428_RS10480	COG1024	Enoyl-CoA hydratase
LK428_RS10485	COG1024	Enoyl-CoA hydratase
LK428_RS10490	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LK428_RS10510	COG0601	transmembrane transport
LK428_RS10515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK428_RS10530	COG2195	Cleaves the N-terminal amino acid of tripeptides
LK428_RS10540	COG0210	DNA helicase
LK428_RS10545	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LK428_RS10550	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LK428_RS10560	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LK428_RS10565	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LK428_RS10570	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LK428_RS10575	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LK428_RS10580	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LK428_RS10585	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LK428_RS10595	COG0356	it plays a direct role in the translocation of protons across the membrane
LK428_RS10610	COG1024	Enoyl-CoA hydratase
LK428_RS10615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LK428_RS10620	COG3634	alkyl hydroperoxide reductase activity
LK428_RS10630	COG0037	tRNA processing
LK428_RS10685	COG1028	Short-chain dehydrogenase reductase Sdr
LK428_RS10690	COG1024	Enoyl-CoA hydratase
LK428_RS10695	COG1960	acyl-CoA dehydrogenase activity
LK428_RS10720	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LK428_RS10725	COG0352	thiamine-phosphate diphosphorylase activity
LK428_RS10740	COG1678	Uncharacterized ACR, COG1678
LK428_RS10745	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LK428_RS10750	COG0540	Belongs to the ATCase OTCase family
LK428_RS10765	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LK428_RS10775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LK428_RS10795	COG0765	amino acid transport
LK428_RS10800	COG1126	abc transporter atp-binding protein
LK428_RS10820	COG1028	Short-chain dehydrogenase reductase Sdr
LK428_RS10830	COG1802	Transcriptional regulator
LK428_RS10850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LK428_RS10870	COG1028	Short-chain dehydrogenase reductase Sdr
LK428_RS10885	COG0134	indole-3-glycerol-phosphate synthase activity
LK428_RS10890	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LK428_RS10895	COG0512	Glutamine amidotransferase of anthranilate synthase
LK428_RS10905	COG0546	phosphoglycolate phosphatase activity
LK428_RS10910	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LK428_RS10915	COG2967	ApaG domain
LK428_RS10920	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LK428_RS10925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LK428_RS10930	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LK428_RS10935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LK428_RS10945	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LK428_RS10950	COG0583	DNA-binding transcription factor activity
LK428_RS10960	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LK428_RS10975	COG0251	oxidation-reduction process
LK428_RS10980	COG1017	nitric oxide dioxygenase activity
LK428_RS10980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LK428_RS11005	COG3723	Recombinational DNA repair protein, rece pathway
LK428_RS11035	COG0582	viral genome integration into host DNA
LK428_RS11070	COG3181	Tripartite tricarboxylate transporter family receptor
LK428_RS11080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LK428_RS11085	COG0028	Belongs to the TPP enzyme family
LK428_RS11110	COG3181	Tripartite tricarboxylate transporter family receptor
LK428_RS11115	COG1024	Enoyl-CoA hydratase
LK428_RS11125	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LK428_RS11130	COG3181	Tripartite tricarboxylate transporter family receptor
LK428_RS11145	COG3181	Tripartite tricarboxylate transporter family receptor
LK428_RS11160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LK428_RS11175	COG1024	Enoyl-CoA hydratase
LK428_RS11190	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LK428_RS11195	COG1309	transcriptional regulator
LK428_RS11200	COG2816	NAD+ diphosphatase activity
LK428_RS11285	COG2979	Protein of unknown function (DUF533)
LK428_RS11305	COG1388	LysM domain
LK428_RS11305	COG0741	lytic transglycosylase activity
LK428_RS11310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LK428_RS11320	COG0328	RNA-DNA hybrid ribonuclease activity
LK428_RS11335	COG2860	membrane
LK428_RS11340	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LK428_RS11345	COG0708	Exodeoxyribonuclease III
LK428_RS11350	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LK428_RS11355	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LK428_RS11360	COG0154	amidase activity
LK428_RS11365	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LK428_RS11370	COG1077	Cell shape determining protein MreB Mrl
LK428_RS11375	COG1792	Involved in formation and maintenance of cell shape
LK428_RS11385	COG0768	penicillin binding
LK428_RS11390	COG0772	Belongs to the SEDS family
LK428_RS11400	COG0471	metal ion transport
LK428_RS11405	COG1309	transcriptional regulator
LK428_RS11415	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LK428_RS11430	COG2823	Periplasmic or secreted lipoprotein
LK428_RS11435	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LK428_RS11450	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LK428_RS11490	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LK428_RS11495	COG0321	lipoyl(octanoyl) transferase activity
LK428_RS11500	COG2921	Belongs to the UPF0250 family
LK428_RS11510	COG1686	Belongs to the peptidase S11 family
LK428_RS11535	COG1127	ABC transporter
LK428_RS11540	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LK428_RS11550	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LK428_RS11565	COG0859	PFAM glycosyl transferase family 9
LK428_RS11595	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LK428_RS11600	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LK428_RS11605	COG0438	transferase activity, transferring glycosyl groups
LK428_RS11645	COG0288	reversible hydration of carbon dioxide
LK428_RS11650	COG0154	amidase activity
LK428_RS11655	COG0683	leucine binding
LK428_RS11660	COG0583	DNA-binding transcription factor activity
LK428_RS11665	COG4211	Belongs to the binding-protein-dependent transport system permease family
LK428_RS11695	COG1464	Belongs to the NlpA lipoprotein family
LK428_RS11875	COG1012	belongs to the aldehyde dehydrogenase family
LK428_RS11895	COG1802	Transcriptional regulator
LK428_RS11910	COG0700	Nucleoside recognition
LK428_RS11915	COG0469	pyruvate kinase activity
LK428_RS11920	COG1929	Belongs to the glycerate kinase type-1 family
LK428_RS11925	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LK428_RS11930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LK428_RS11935	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LK428_RS11945	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LK428_RS11955	COG2154	pterin-4-alpha-carbinolamine dehydratase
LK428_RS11975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LK428_RS11980	COG0154	amidase activity
LK428_RS11990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK428_RS11995	COG0601	transmembrane transport
LK428_RS12000	COG0747	negative chemotaxis
LK428_RS12020	COG0019	diaminopimelate decarboxylase activity
LK428_RS12040	COG3712	iron ion homeostasis
LK428_RS12045	COG4774	siderophore transport
LK428_RS12050	COG2353	YceI-like domain
LK428_RS12070	COG0242	peptide deformylase activity
LK428_RS12085	COG0204	Acyl-transferase
LK428_RS12090	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LK428_RS12095	COG0751	glycine-tRNA ligase activity
LK428_RS12100	COG0752	glycyl-tRNA synthetase alpha subunit
LK428_RS12115	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LK428_RS12125	COG0494	nUDIX hydrolase
LK428_RS12160	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
LK428_RS12165	COG0237	dephospho-CoA kinase activity
LK428_RS12170	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LK428_RS12185	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LK428_RS12190	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LK428_RS12200	COG0477	Major facilitator Superfamily
LK428_RS12205	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LK428_RS12220	COG1126	abc transporter atp-binding protein
LK428_RS12225	COG0765	amino acid transport
LK428_RS12230	COG4597	amino acid ABC transporter
LK428_RS12235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK428_RS12240	COG2884	Cell division ATP-binding protein ftsE
LK428_RS12245	COG2177	Part of the ABC transporter FtsEX involved in
LK428_RS12250	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
LK428_RS12260	COG1194	a g-specific adenine glycosylase
LK428_RS12270	COG2226	methyltransferase
LK428_RS12285	COG0745	RESPONSE REGULATOR receiver
LK428_RS12315	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LK428_RS12320	COG0085	RNA polymerase activity
LK428_RS12325	COG0222	ribosome binding
LK428_RS12330	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LK428_RS12335	COG0081	regulation of translation
LK428_RS12340	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LK428_RS12350	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LK428_RS12360	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LK428_RS12385	COG1475	DNA binding
LK428_RS12395	COG1192	Involved in chromosome partitioning
LK428_RS12400	COG0357	Ribosomal RNA small subunit methyltransferase G
LK428_RS12405	COG0445	tRNA wobble uridine modification
LK428_RS12410	COG1278	Cold shock
LK428_RS12415	COG0436	Aminotransferase
LK428_RS12450	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LK428_RS12455	COG0747	negative chemotaxis
LK428_RS12470	COG0444	Belongs to the ABC transporter superfamily
LK428_RS12475	COG4608	Belongs to the ABC transporter superfamily
LK428_RS12480	COG1473	amidohydrolase
LK428_RS12485	COG2175	clavaminate synthase activity
LK428_RS12495	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LK428_RS12500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LK428_RS12505	COG0753	catalase activity
LK428_RS12535	COG1054	Belongs to the UPF0176 family
LK428_RS12540	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LK428_RS12540	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LK428_RS12550	COG0489	protein tyrosine kinase activity
LK428_RS12565	COG0717	Belongs to the dCTP deaminase family
LK428_RS12595	COG2081	HI0933 family
LK428_RS12630	COG2259	Doxx family
LK428_RS12635	COG0583	DNA-binding transcription factor activity
LK428_RS12650	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LK428_RS12655	COG0167	dihydroorotate dehydrogenase activity
LK428_RS12675	COG1414	Transcriptional regulator
LK428_RS12680	COG1058	Belongs to the CinA family
LK428_RS12680	COG1546	Belongs to the CinA family
LK428_RS12700	COG0513	Belongs to the DEAD box helicase family
LK428_RS12730	COG0429	hydrolase of the alpha beta-hydrolase fold
LK428_RS12735	COG4783	chaperone-mediated protein folding
LK428_RS12750	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LK428_RS12765	COG0006	proline dipeptidase activity
LK428_RS12775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LK428_RS12795	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LK428_RS12800	COG0632	four-way junction helicase activity
LK428_RS12815	COG2255	four-way junction helicase activity
LK428_RS12820	COG0514	ATP-dependent DNA helicase (RecQ)
LK428_RS12855	COG1271	oxidase subunit
LK428_RS12860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LK428_RS12865	COG0850	regulation of cytokinetic process
LK428_RS12870	COG2894	cell division
LK428_RS12875	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LK428_RS12895	COG0488	(ABC) transporter
LK428_RS12920	COG1215	transferase activity, transferring glycosyl groups
LK428_RS12930	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LK428_RS12940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LK428_RS12960	COG0318	PFAM AMP-dependent synthetase and ligase
LK428_RS12965	COG2188	Transcriptional regulator
LK428_RS12970	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LK428_RS12985	COG0259	pyridoxamine-phosphate oxidase activity
LK428_RS12990	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LK428_RS13005	COG0583	DNA-binding transcription factor activity
LK428_RS13070	COG2135	peptidase activity
LK428_RS13085	COG0494	nUDIX hydrolase
LK428_RS13090	COG0442	prolyl-tRNA aminoacylation
LK428_RS13095	COG0824	Thioesterase
LK428_RS13100	COG0811	peptide transport
LK428_RS13105	COG0848	biopolymer transport protein
LK428_RS13115	COG0823	Involved in the tonB-independent uptake of proteins
LK428_RS13130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LK428_RS13135	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LK428_RS13165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK428_RS13170	COG0601	transmembrane transport
LK428_RS13175	COG0747	negative chemotaxis
LK428_RS13180	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LK428_RS13200	COG0697	spore germination
LK428_RS13210	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
LK428_RS13215	COG2948	multi-organism process
LK428_RS13220	COG3504	Conjugal transfer protein
LK428_RS13225	COG3736	Type IV secretory pathway, component VirB8
LK428_RS13240	COG3451	type IV secretory pathway VirB4
LK428_RS13245	COG3702	type iv secretory pathway
LK428_RS13280	COG3181	Tripartite tricarboxylate transporter family receptor
LK428_RS13305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LK428_RS13310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LK428_RS13315	COG0537	adenosine 5'-monophosphoramidase activity
LK428_RS13320	COG0140	phosphoribosyl-ATP diphosphatase activity
LK428_RS13330	COG0107	imidazoleglycerol-phosphate synthase activity
LK428_RS13335	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LK428_RS13340	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LK428_RS13345	COG0131	Imidazoleglycerol-phosphate dehydratase
LK428_RS13350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LK428_RS13355	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LK428_RS13360	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LK428_RS13365	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LK428_RS13375	COG0842	Transport permease protein
LK428_RS13380	COG1131	(ABC) transporter
LK428_RS13390	COG2853	Lipoprotein
LK428_RS13395	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LK428_RS13400	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LK428_RS13405	COG1127	ABC transporter
LK428_RS13415	COG3047	cAMP biosynthetic process
LK428_RS13425	COG0067	glutamate synthase
LK428_RS13425	COG0069	glutamate synthase activity
LK428_RS13425	COG0070	glutamate synthase
LK428_RS13435	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LK428_RS13440	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LK428_RS13450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LK428_RS13455	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LK428_RS13475	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LK428_RS13520	COG1999	signal sequence binding
LK428_RS13540	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LK428_RS13545	COG2814	Major facilitator Superfamily
LK428_RS13575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LK428_RS13580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK428_RS13595	COG0758	DNA mediated transformation
LK428_RS13600	COG1522	sequence-specific DNA binding
LK428_RS13610	COG0242	peptide deformylase activity
LK428_RS13615	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LK428_RS13625	COG0546	phosphoglycolate phosphatase activity
LK428_RS13645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LK428_RS13650	COG1942	4-Oxalocrotonate Tautomerase
LK428_RS13655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LK428_RS13680	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
LK428_RS13690	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LK428_RS13690	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LK428_RS13700	COG5000	phosphorelay sensor kinase activity
LK428_RS13705	COG2204	response regulator
LK428_RS13730	COG2068	MobA-Related Protein
LK428_RS13740	COG3473	Maleate cis-trans isomerase
LK428_RS13750	COG2309	aminopeptidase activity
LK428_RS13755	COG1335	isochorismatase
LK428_RS13780	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LK428_RS13805	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LK428_RS13810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LK428_RS13830	COG2226	methyltransferase
LK428_RS13845	COG3181	Tripartite tricarboxylate transporter family receptor
LK428_RS13850	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LK428_RS13855	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LK428_RS13860	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LK428_RS13865	COG1054	Belongs to the UPF0176 family
LK428_RS13870	COG0588	phosphoglycerate mutase activity
LK428_RS13875	COG4942	peptidase
LK428_RS13880	COG0793	Belongs to the peptidase S41A family
LK428_RS13885	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LK428_RS13915	COG2969	positive regulation of protein catabolic process
LK428_RS13920	COG0625	glutathione transferase activity
LK428_RS13925	COG2857	Cytochrome c1
LK428_RS13930	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LK428_RS13935	COG0723	plastoquinol--plastocyanin reductase activity
LK428_RS13940	COG1970	mechanosensitive ion channel activity
LK428_RS13945	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LK428_RS13960	COG2031	fatty acid transporter
LK428_RS13965	COG1012	belongs to the aldehyde dehydrogenase family
LK428_RS13980	COG1278	Cold shock
LK428_RS13985	COG0583	DNA-binding transcription factor activity
LK428_RS14005	COG0183	Belongs to the thiolase family
LK428_RS14015	COG1960	acyl-CoA dehydrogenase activity
LK428_RS14020	COG0583	DNA-binding transcription factor activity
LK428_RS14025	COG3181	Tripartite tricarboxylate transporter family receptor
LK428_RS14030	COG1024	Enoyl-CoA hydratase
LK428_RS14035	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LK428_RS14040	COG1253	flavin adenine dinucleotide binding
LK428_RS14045	COG1285	pathogenesis
LK428_RS14055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LK428_RS14085	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LK428_RS14100	COG2031	fatty acid transporter
LK428_RS14110	COG0786	glutamate:sodium symporter activity
LK428_RS14120	COG0463	Glycosyl transferase, family 2
LK428_RS14155	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LK428_RS14155	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LK428_RS14160	COG0509	glycine decarboxylation via glycine cleavage system
LK428_RS14165	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LK428_RS14175	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LK428_RS14190	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LK428_RS14255	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LK428_RS14260	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LK428_RS14330	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LK428_RS14335	COG1280	lysine exporter protein (LysE YggA)
LK428_RS14340	COG0513	Belongs to the DEAD box helicase family
LK428_RS14350	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
LK428_RS14355	COG4608	Belongs to the ABC transporter superfamily
LK428_RS14385	COG0326	Molecular chaperone. Has ATPase activity
LK428_RS14390	COG0625	glutathione transferase activity
LK428_RS14410	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LK428_RS14415	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LK428_RS14420	COG1652	LysM domain
LK428_RS14435	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LK428_RS14450	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LK428_RS14530	COG1595	DNA-templated transcription, initiation
LK428_RS14535	COG3712	iron ion homeostasis
LK428_RS14545	COG3720	iron ion transport
LK428_RS14550	COG4558	Periplasmic binding protein
LK428_RS14555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LK428_RS14560	COG1120	ATPase activity
LK428_RS14565	COG1683	Conserved Protein
LK428_RS14595	COG3064	Membrane
LK428_RS14615	COG1234	tRNA 3'-trailer cleavage
LK428_RS14660	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LK428_RS14665	COG1802	Transcriptional regulator
LK428_RS14675	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LK428_RS14720	COG3181	Tripartite tricarboxylate transporter family receptor
LK428_RS14730	COG0277	FAD linked oxidase domain protein
LK428_RS14735	COG1960	acyl-CoA dehydrogenase activity
LK428_RS14740	COG1960	acyl-CoA dehydrogenase activity
LK428_RS14750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LK428_RS14765	COG2072	flavoprotein involved in K transport
LK428_RS14770	COG0604	alcohol dehydrogenase
LK428_RS14785	COG1024	Enoyl-CoA hydratase
LK428_RS14805	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LK428_RS14810	COG1522	sequence-specific DNA binding
LK428_RS14815	COG0183	Belongs to the thiolase family
LK428_RS14825	COG1960	acyl-CoA dehydrogenase activity
LK428_RS14885	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LK428_RS14890	COG1660	Displays ATPase and GTPase activities
LK428_RS14900	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LK428_RS14900	COG2010	Cytochrome c
LK428_RS14915	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LK428_RS14925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LK428_RS14930	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
LK428_RS14940	COG0583	DNA-binding transcription factor activity
LK428_RS14950	COG0142	geranyltranstransferase activity
LK428_RS14960	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LK428_RS14965	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LK428_RS14970	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LK428_RS14975	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LK428_RS15005	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LK428_RS15015	COG0018	arginyl-trna synthetase
LK428_RS15035	COG0395	ABC-type sugar transport system, permease component
LK428_RS15040	COG1175	transmembrane transport
LK428_RS15045	COG1653	transport
LK428_RS15050	COG3842	ATPase activity
LK428_RS15055	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LK428_RS15065	COG0492	ferredoxin-NADP+ reductase activity
LK428_RS15090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LK428_RS15100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LK428_RS15145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LK428_RS15150	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LK428_RS15150	COG2813	Specifically methylates the guanine in position
LK428_RS15160	COG2223	nitrite transmembrane transporter activity
LK428_RS15165	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LK428_RS15170	COG1794	racemase activity, acting on amino acids and derivatives
LK428_RS15175	COG1126	abc transporter atp-binding protein
LK428_RS15180	COG0765	amino acid transport
LK428_RS15185	COG0765	amino acid transport
LK428_RS15190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK428_RS15205	COG1950	PFAM Membrane protein of
LK428_RS15210	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LK428_RS15225	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LK428_RS15235	COG1560	Kdo2-lipid A biosynthetic process
LK428_RS15240	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LK428_RS15250	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LK428_RS15260	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
LK428_RS15270	COG0803	Belongs to the bacterial solute-binding protein 9 family
LK428_RS15290	COG0735	belongs to the Fur family
LK428_RS15295	COG0523	cobalamin synthesis protein
LK428_RS15305	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LK428_RS15315	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LK428_RS15325	COG2096	Adenosyltransferase
LK428_RS15335	COG0583	DNA-binding transcription factor activity
LK428_RS15345	COG0477	Major facilitator Superfamily
LK428_RS15360	COG0617	tRNA 3'-terminal CCA addition
LK428_RS15370	COG0513	Belongs to the DEAD box helicase family
LK428_RS15375	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LK428_RS15385	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LK428_RS15390	COG2084	Dehydrogenase
LK428_RS15445	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LK428_RS15450	COG0129	dihydroxy-acid dehydratase activity
LK428_RS15455	COG4654	Cytochrome c, class I
LK428_RS15460	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LK428_RS15510	COG1473	amidohydrolase
LK428_RS15515	COG0418	dihydroorotase activity
LK428_RS15520	COG0488	(ABC) transporter
LK428_RS15530	COG2001	Belongs to the MraZ family
LK428_RS15535	COG0275	rRNA processing
LK428_RS15540	COG3116	cell division
LK428_RS15550	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LK428_RS15555	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LK428_RS15560	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LK428_RS15570	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LK428_RS15575	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LK428_RS15580	COG1181	Belongs to the D-alanine--D-alanine ligase family
LK428_RS15585	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LK428_RS15595	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LK428_RS15600	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LK428_RS15610	COG0739	heme binding
LK428_RS15615	COG0653	protein targeting
LK428_RS15640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LK428_RS15645	COG1522	sequence-specific DNA binding
LK428_RS15675	COG0154	amidase activity
LK428_RS15680	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LK428_RS15685	COG1024	Enoyl-CoA hydratase
LK428_RS15700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LK428_RS15715	COG1028	Short-chain dehydrogenase reductase Sdr
LK428_RS15720	COG1414	Transcriptional regulator
LK428_RS15735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LK428_RS15740	COG0251	oxidation-reduction process
LK428_RS15745	COG0559	Belongs to the binding-protein-dependent transport system permease family
LK428_RS15765	COG1902	pentaerythritol trinitrate reductase activity
LK428_RS15775	COG0583	DNA-binding transcription factor activity
LK428_RS15785	COG0590	tRNA wobble adenosine to inosine editing
LK428_RS15790	COG2807	transmembrane transport
LK428_RS15800	COG3181	Tripartite tricarboxylate transporter family receptor
LK428_RS15805	COG0154	amidase activity
LK428_RS15810	COG0307	riboflavin synthase, alpha
LK428_RS15815	COG3181	Tripartite tricarboxylate transporter family receptor
LK428_RS15820	COG1522	sequence-specific DNA binding
LK428_RS15830	COG0318	PFAM AMP-dependent synthetase and ligase
LK428_RS15840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LK428_RS15850	COG0583	DNA-binding transcription factor activity
LK428_RS15860	COG0477	Major facilitator Superfamily
LK428_RS15865	COG1028	Short-chain dehydrogenase reductase Sdr
LK428_RS15880	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LK428_RS15885	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LK428_RS15890	COG0583	DNA-binding transcription factor activity
LK428_RS15900	COG1448	Aminotransferase
LK428_RS15905	COG1418	mRNA catabolic process
LK428_RS15935	COG1063	alcohol dehydrogenase
LK428_RS15945	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LK428_RS16005	COG1028	Short-chain dehydrogenase reductase Sdr
LK428_RS16010	COG1309	transcriptional regulator
LK428_RS16015	COG2982	Protein involved in outer membrane biogenesis
LK428_RS16020	COG2818	Glycosylase
LK428_RS16040	COG1653	transport
LK428_RS16045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LK428_RS16050	COG3842	ATPase activity
LK428_RS16055	COG0395	ABC-type sugar transport system, permease component
LK428_RS16060	COG1175	transmembrane transport
LK428_RS16085	COG3181	Tripartite tricarboxylate transporter family receptor
LK428_RS16090	COG2186	Transcriptional regulator
LK428_RS16110	COG1454	alcohol dehydrogenase
LK428_RS16125	COG2011	ABC-type metal ion transport system permease component
LK428_RS16130	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LK428_RS16135	COG1501	Belongs to the glycosyl hydrolase 31 family
LK428_RS16160	COG0318	PFAM AMP-dependent synthetase and ligase
LK428_RS16165	COG1473	amidohydrolase
LK428_RS16175	COG2855	membrane
LK428_RS16185	COG2239	Acts as a magnesium transporter
LK428_RS16200	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LK428_RS16205	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LK428_RS16210	COG2890	protein-(glutamine-N5) methyltransferase activity
LK428_RS16215	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LK428_RS16225	COG3181	Tripartite tricarboxylate transporter family receptor
LK428_RS16270	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LK428_RS16275	COG0049	tRNA binding
LK428_RS16280	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LK428_RS16285	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LK428_RS16290	COG0051	transcription antitermination factor activity, RNA binding
LK428_RS16295	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LK428_RS16300	COG0088	Forms part of the polypeptide exit tunnel
LK428_RS16305	COG0089	rRNA binding
LK428_RS16310	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LK428_RS16315	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LK428_RS16320	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LK428_RS16325	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LK428_RS16330	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LK428_RS16335	COG0255	Belongs to the universal ribosomal protein uL29 family
LK428_RS16340	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LK428_RS16360	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LK428_RS16365	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LK428_RS16370	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LK428_RS16375	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LK428_RS16380	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LK428_RS16385	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LK428_RS16390	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LK428_RS16395	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LK428_RS16400	COG1841	ribosomal large subunit assembly
LK428_RS16405	COG0200	Binds to the 23S rRNA
LK428_RS16410	COG0201	protein transport
LK428_RS16415	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LK428_RS16420	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LK428_RS16425	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LK428_RS16430	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LK428_RS16435	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LK428_RS16440	COG0202	RNA polymerase activity
LK428_RS16445	COG0203	ribosomal protein L17
LK428_RS16450	COG0537	adenosine 5'-monophosphoramidase activity
LK428_RS16455	COG1324	tolerance protein
LK428_RS16460	COG4232	protein-disulfide reductase activity
LK428_RS16475	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LK428_RS16485	COG1333	cytochrome c biogenesis protein
LK428_RS16490	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LK428_RS16505	COG1965	Belongs to the frataxin family
LK428_RS16515	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LK428_RS16520	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LK428_RS16525	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LK428_RS16545	COG2814	Major facilitator Superfamily
LK428_RS16550	COG0629	single-stranded DNA binding
LK428_RS16600	COG0402	S-adenosylhomocysteine deaminase activity
LK428_RS16630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LK428_RS16650	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LK428_RS16675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LK428_RS16680	COG1956	GAF domain-containing protein
LK428_RS16685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LK428_RS16700	COG0251	oxidation-reduction process
LK428_RS16710	COG0330	HflC and HflK could
LK428_RS16715	COG3422	double-strand break repair
LK428_RS16755	COG3181	Tripartite tricarboxylate transporter family receptor
LK428_RS16760	COG0318	PFAM AMP-dependent synthetase and ligase
LK428_RS16765	COG1414	Transcriptional regulator
LK428_RS16770	COG1024	Enoyl-CoA hydratase
LK428_RS16775	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LK428_RS16780	COG3181	Tripartite tricarboxylate transporter family receptor
LK428_RS16795	COG0604	alcohol dehydrogenase
LK428_RS16805	COG1028	Short-chain dehydrogenase reductase Sdr
LK428_RS16810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LK428_RS16825	COG1960	acyl-CoA dehydrogenase activity
LK428_RS16875	COG2030	dehydratase
LK428_RS16910	COG0583	DNA-binding transcription factor activity
LK428_RS16915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LK428_RS16950	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
LK428_RS16960	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LK428_RS16965	COG1845	cytochrome c oxidase, subunit III
LK428_RS16970	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LK428_RS16975	COG0640	Transcriptional regulator
LK428_RS16995	COG3220	belongs to the UPF0276 family
LK428_RS17025	COG4942	peptidase
LK428_RS17040	COG1666	GTP binding
LK428_RS17075	COG0312	modulator of DNA gyrase
LK428_RS17080	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LK428_RS17095	COG3064	Membrane
LK428_RS17095	COG3210	domain, Protein
LK428_RS17095	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
LK428_RS17095	COG3064	Membrane
LK428_RS17095	COG3210	domain, Protein
LK428_RS17095	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
LK428_RS17100	COG0277	FAD linked oxidase domain protein
LK428_RS17105	COG0277	FAD linked oxidase domain protein
LK428_RS17110	COG0277	FAD linked oxidase domain protein
LK428_RS17115	COG0247	lactate metabolic process
LK428_RS17120	COG2819	hydrolase of the alpha beta superfamily
LK428_RS17160	COG0583	DNA-binding transcription factor activity
LK428_RS17165	COG0482	sulfurtransferase activity
LK428_RS17170	COG0730	response to heat
LK428_RS17175	COG0625	glutathione transferase activity
LK428_RS17180	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LK428_RS17185	COG3909	cytochrome
LK428_RS17220	COG1802	Transcriptional regulator
LK428_RS17225	COG3069	C4-dicarboxylate transmembrane transporter activity
LK428_RS17230	COG0513	Belongs to the DEAD box helicase family
LK428_RS17235	COG0346	lactoylglutathione lyase activity
LK428_RS17240	COG1335	isochorismatase
LK428_RS17245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LK428_RS17250	COG1116	anion transmembrane transporter activity
LK428_RS17265	COG3028	Belongs to the UPF0307 family
LK428_RS17270	COG0312	modulator of DNA gyrase
LK428_RS17280	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LK428_RS17285	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LK428_RS17290	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LK428_RS17300	COG0316	Belongs to the HesB IscA family
LK428_RS17305	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LK428_RS17315	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LK428_RS17325	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LK428_RS17330	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LK428_RS17345	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LK428_RS17345	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LK428_RS17355	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LK428_RS17365	COG0557	exoribonuclease II activity
LK428_RS17370	COG3150	esterase
LK428_RS17375	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LK428_RS17380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LK428_RS17385	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LK428_RS17390	COG0511	ligase activity, forming carbon-carbon bonds
LK428_RS17395	COG0439	Biotin carboxylase
LK428_RS17410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LK428_RS17430	COG1696	Membrane protein involved in D-alanine export
LK428_RS17435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LK428_RS17465	COG1522	sequence-specific DNA binding
LK428_RS17480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LK428_RS17485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LK428_RS17485	COG0045	succinate-CoA ligase (ADP-forming) activity
LK428_RS17485	COG1042	CoA-binding domain protein
LK428_RS17505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK428_RS17510	COG0601	transmembrane transport
LK428_RS17515	COG0747	negative chemotaxis
LK428_RS17525	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LK428_RS17530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LK428_RS17540	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LK428_RS17550	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
LK428_RS17555	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LK428_RS17560	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LK428_RS17575	COG0438	transferase activity, transferring glycosyl groups
LK428_RS17590	COG0438	transferase activity, transferring glycosyl groups
LK428_RS17595	COG0438	transferase activity, transferring glycosyl groups
LK428_RS17600	COG0166	Belongs to the GPI family
LK428_RS17615	COG0277	FAD linked oxidase domain protein
LK428_RS17620	COG0745	RESPONSE REGULATOR receiver
LK428_RS17625	COG0642	Histidine kinase
LK428_RS17630	COG1368	sulfuric ester hydrolase activity
LK428_RS17640	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LK428_RS17665	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LK428_RS17675	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LK428_RS17680	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LK428_RS17690	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LK428_RS17695	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LK428_RS17700	COG0193	aminoacyl-tRNA hydrolase activity
LK428_RS17710	COG0012	GTP binding
LK428_RS17715	COG0582	viral genome integration into host DNA
LK428_RS17735	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LK428_RS17785	COG0745	RESPONSE REGULATOR receiver
LK428_RS17790	COG3181	Tripartite tricarboxylate transporter family receptor
LK428_RS17795	COG1309	transcriptional regulator
LK428_RS17825	COG2321	neutral zinc metallopeptidase
LK428_RS17830	COG0009	L-threonylcarbamoyladenylate synthase
LK428_RS17845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LK428_RS17850	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
LK428_RS17855	COG3539	Fimbrial protein
LK428_RS17860	COG2850	peptidyl-arginine hydroxylation
LK428_RS17865	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LK428_RS17870	COG3360	Dodecin
LK428_RS17915	COG3706	GGDEF domain
LK428_RS17955	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
LK428_RS17965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LK428_RS17980	COG0069	glutamate synthase activity
LK428_RS17985	COG2391	methyltransferase activity
LK428_RS17990	COG0679	Auxin Efflux Carrier
LK428_RS18015	COG0557	exoribonuclease II activity
LK428_RS18020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LK428_RS18030	COG3128	pkhd-type hydroxylase
LK428_RS18035	COG0776	regulation of translation
LK428_RS18065	COG0642	Histidine kinase
LK428_RS18070	COG3158	transport of potassium into the cell
LK428_RS18075	COG0137	argininosuccinate synthase activity
LK428_RS18080	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LK428_RS18085	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LK428_RS18095	COG0583	DNA-binding transcription factor activity
LK428_RS18105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LK428_RS18125	COG2186	Transcriptional regulator
LK428_RS18135	COG2223	nitrite transmembrane transporter activity
LK428_RS18145	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LK428_RS18150	COG0450	alkyl hydroperoxide reductase
LK428_RS18170	COG1214	PFAM Peptidase M22, glycoprotease
LK428_RS18175	COG1573	uracil-dna glycosylase
LK428_RS18180	COG0477	Major facilitator Superfamily
LK428_RS18185	COG1196	nuclear chromosome segregation
LK428_RS18195	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LK428_RS18200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LK428_RS18205	COG0271	Belongs to the BolA IbaG family
LK428_RS18215	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LK428_RS18220	COG1122	ATPase activity
LK428_RS18225	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LK428_RS18230	COG1268	BioY protein
LK428_RS18250	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LK428_RS18285	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LK428_RS18290	COG2878	Part of a membrane complex involved in electron transport
LK428_RS18305	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LK428_RS18310	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LK428_RS18315	COG0251	oxidation-reduction process
LK428_RS18325	COG3228	Belongs to the MtfA family
LK428_RS18330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LK428_RS18350	COG0133	tryptophan synthase activity
LK428_RS18355	COG0159	tryptophan synthase activity
LK428_RS18360	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LK428_RS18380	COG1530	ribonuclease E activity
LK428_RS18390	COG0546	phosphoglycolate phosphatase activity
LK428_RS18395	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LK428_RS18400	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
LK428_RS18410	COG3023	N-Acetylmuramoyl-L-alanine amidase
LK428_RS18420	COG0424	maF-like protein
LK428_RS18425	COG1399	metal-binding, possibly nucleic acid-binding protein
LK428_RS18430	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LK428_RS18435	COG0416	fatty acid biosynthetic process
LK428_RS18440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LK428_RS18455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LK428_RS18460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LK428_RS18485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LK428_RS18490	COG0481	GTPase activity
LK428_RS18495	COG0681	Belongs to the peptidase S26 family
LK428_RS18500	COG0571	ribonuclease III activity
LK428_RS18505	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LK428_RS18510	COG1381	Involved in DNA repair and RecF pathway recombination
LK428_RS18520	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LK428_RS18530	COG3181	Tripartite tricarboxylate transporter family receptor
LK428_RS18535	COG0670	Belongs to the BI1 family
LK428_RS18550	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LK428_RS18560	COG0583	DNA-binding transcription factor activity
LK428_RS18575	COG0583	DNA-binding transcription factor activity
LK428_RS18590	COG0791	NLP P60 protein
LK428_RS18600	COG3193	protein, possibly involved in utilization of glycolate and propanediol
LK428_RS18615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LK428_RS18620	COG0697	spore germination
LK428_RS18650	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LK428_RS18680	COG1446	asparaginase
LK428_RS18685	COG4172	Belongs to the ABC transporter superfamily
LK428_RS18690	COG0747	negative chemotaxis
LK428_RS18700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK428_RS18720	COG0504	CTP synthase activity
LK428_RS18725	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LK428_RS18735	COG0148	phosphopyruvate hydratase activity
LK428_RS18740	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LK428_RS18770	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LK428_RS18780	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LK428_RS18805	COG1981	membrane
LK428_RS18835	COG0039	L-malate dehydrogenase activity
LK428_RS18840	COG2188	Transcriptional regulator
LK428_RS18845	COG2009	succinate dehydrogenase
LK428_RS18850	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LK428_RS18855	COG1053	succinate dehydrogenase
LK428_RS18860	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LK428_RS18865	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LK428_RS18870	COG0372	Belongs to the citrate synthase family
LK428_RS18895	COG1193	negative regulation of DNA recombination
LK428_RS18900	COG0492	ferredoxin-NADP+ reductase activity
LK428_RS18905	COG1674	ftsk spoiiie
LK428_RS18910	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LK428_RS18915	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LK428_RS18920	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LK428_RS18945	COG3706	GGDEF domain
LK428_RS18965	COG2814	Major facilitator Superfamily
LK428_RS18995	COG3486	L-lysine 6-monooxygenase (NADPH) activity
LK428_RS19010	COG1028	Short-chain dehydrogenase reductase Sdr
LK428_RS19020	COG3022	response to hydroperoxide
LK428_RS19045	COG0028	Belongs to the TPP enzyme family
LK428_RS19050	COG0440	acetolactate synthase activity
LK428_RS19060	COG1183	phosphatidylcholine synthase activity
LK428_RS19070	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LK428_RS19075	COG1185	polyribonucleotide nucleotidyltransferase activity
LK428_RS19095	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LK428_RS19100	COG0303	'Molybdopterin
LK428_RS19105	COG0521	Mo-molybdopterin cofactor biosynthetic process
LK428_RS19120	COG0315	cyclic pyranopterin monophosphate synthase activity
LK428_RS19130	COG0412	Dienelactone hydrolase
LK428_RS19140	COG0678	peroxiredoxin activity
LK428_RS19150	COG0697	spore germination
LK428_RS19155	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LK428_RS19190	COG0667	Aldo Keto reductase
LK428_RS19200	COG4535	Mg2 and Co2 transporter CorC
LK428_RS19205	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LK428_RS19210	COG1702	phosphate starvation-inducible protein PhoH
LK428_RS19215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LK428_RS19235	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LK428_RS19240	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LK428_RS19245	COG1862	Preprotein translocase
LK428_RS19250	COG0343	queuine tRNA-ribosyltransferase activity
LK428_RS19255	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LK428_RS19260	COG2027	D-alanyl-D-alanine carboxypeptidase
LK428_RS19265	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LK428_RS19275	COG3468	outer membrane autotransporter barrel domain protein
LK428_RS19280	COG1648	precorrin-2 dehydrogenase activity
LK428_RS19280	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LK428_RS19305	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LK428_RS19310	COG0741	lytic transglycosylase activity
LK428_RS19315	COG0436	Aminotransferase
LK428_RS19325	COG0281	malic enzyme
LK428_RS19325	COG0280	phosphate acetyltransferase
LK428_RS19335	COG2732	(Barnase) inhibitor
LK428_RS19360	COG0235	Class ii aldolase
LK428_RS19365	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LK428_RS19370	COG0720	synthase
LK428_RS19375	COG0602	queuosine metabolic process
LK428_RS19400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LK428_RS19435	COG3181	Tripartite tricarboxylate transporter family receptor
LK428_RS19465	COG3842	ATPase activity
LK428_RS19475	COG0395	ABC-type sugar transport system, permease component
LK428_RS19505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LK428_RS19510	COG0420	3'-5' exonuclease activity
LK428_RS19540	COG0519	Catalyzes the synthesis of GMP from XMP
LK428_RS19540	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LK428_RS19550	COG3550	peptidyl-serine autophosphorylation
LK428_RS19560	COG0477	Major facilitator Superfamily
LK428_RS19575	COG1228	amidohydrolase
LK428_RS19585	COG1116	anion transmembrane transporter activity
LK428_RS19590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LK428_RS19640	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LK428_RS19670	COG2814	Major facilitator Superfamily
LK428_RS19695	COG1280	lysine exporter protein (LysE YggA)
LK428_RS19715	COG0747	negative chemotaxis
LK428_RS19720	COG0601	transmembrane transport
LK428_RS19725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK428_RS19730	COG4172	Belongs to the ABC transporter superfamily
LK428_RS19735	COG1609	Transcriptional regulator
LK428_RS19765	COG0586	Pfam SNARE associated Golgi protein
LK428_RS19780	COG0500	methyltransferase
LK428_RS19810	COG0776	regulation of translation
LK428_RS19815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LK428_RS19815	COG0072	phenylalanine-tRNA ligase activity
LK428_RS19860	COG2175	clavaminate synthase activity
LK428_RS19920	COG4608	Belongs to the ABC transporter superfamily
LK428_RS19955	COG0318	PFAM AMP-dependent synthetase and ligase