locus-tag	class	description
D0Z02_RS00045	COG0601	transmembrane transport
D0Z02_RS00050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0Z02_RS00085	COG0640	Transcriptional regulator
D0Z02_RS00100	COG3135	benzoate transporter
D0Z02_RS00105	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D0Z02_RS00110	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D0Z02_RS00115	COG0742	ribosomal rna small subunit methyltransferase
D0Z02_RS00135	COG3639	organic phosphonate transmembrane transporter activity
D0Z02_RS00140	COG3639	organic phosphonate transmembrane transporter activity
D0Z02_RS00180	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D0Z02_RS00185	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D0Z02_RS00195	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D0Z02_RS00200	COG1058	Belongs to the CinA family
D0Z02_RS00200	COG1546	Belongs to the CinA family
D0Z02_RS00205	COG0284	orotidine-5'-phosphate decarboxylase activity
D0Z02_RS00210	COG1252	NADH dehydrogenase
D0Z02_RS00230	COG0459	protein refolding
D0Z02_RS00235	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D0Z02_RS00255	COG1053	succinate dehydrogenase
D0Z02_RS00265	COG0583	DNA-binding transcription factor activity
D0Z02_RS00270	COG1053	succinate dehydrogenase
D0Z02_RS00295	COG3706	GGDEF domain
D0Z02_RS00335	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
D0Z02_RS00345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D0Z02_RS00355	COG0069	glutamate synthase activity
D0Z02_RS00360	COG2391	methyltransferase activity
D0Z02_RS00365	COG0679	Auxin Efflux Carrier
D0Z02_RS00390	COG0557	exoribonuclease II activity
D0Z02_RS00410	COG0776	regulation of translation
D0Z02_RS00440	COG0642	Histidine kinase
D0Z02_RS00445	COG3158	transport of potassium into the cell
D0Z02_RS00450	COG0137	argininosuccinate synthase activity
D0Z02_RS00455	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D0Z02_RS00460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D0Z02_RS00470	COG0583	DNA-binding transcription factor activity
D0Z02_RS00500	COG2186	Transcriptional regulator
D0Z02_RS00510	COG2223	nitrite transmembrane transporter activity
D0Z02_RS00520	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D0Z02_RS00525	COG0450	alkyl hydroperoxide reductase
D0Z02_RS00555	COG1573	uracil-dna glycosylase
D0Z02_RS00565	COG1196	nuclear chromosome segregation
D0Z02_RS00575	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D0Z02_RS00580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D0Z02_RS00595	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0Z02_RS00600	COG1122	ATPase activity
D0Z02_RS00605	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D0Z02_RS00610	COG1268	BioY protein
D0Z02_RS00630	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D0Z02_RS00665	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D0Z02_RS00670	COG2878	Part of a membrane complex involved in electron transport
D0Z02_RS00685	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D0Z02_RS00690	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D0Z02_RS00695	COG0251	oxidation-reduction process
D0Z02_RS00705	COG3228	Belongs to the MtfA family
D0Z02_RS00710	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D0Z02_RS00720	COG0133	tryptophan synthase activity
D0Z02_RS00725	COG0159	tryptophan synthase activity
D0Z02_RS00730	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D0Z02_RS00765	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D0Z02_RS00770	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D0Z02_RS00780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0Z02_RS00785	COG0583	DNA-binding transcription factor activity
D0Z02_RS00795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0Z02_RS00815	COG0251	oxidation-reduction process
D0Z02_RS00825	COG2031	fatty acid transporter
D0Z02_RS00830	COG1012	belongs to the aldehyde dehydrogenase family
D0Z02_RS00835	COG1802	Transcriptional regulator
D0Z02_RS00845	COG1278	Cold shock
D0Z02_RS00850	COG0583	DNA-binding transcription factor activity
D0Z02_RS00865	COG0183	Belongs to the thiolase family
D0Z02_RS00875	COG1960	acyl-CoA dehydrogenase activity
D0Z02_RS00880	COG0583	DNA-binding transcription factor activity
D0Z02_RS00885	COG3181	Tripartite tricarboxylate transporter family receptor
D0Z02_RS00890	COG1024	Enoyl-CoA hydratase
D0Z02_RS00895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0Z02_RS00905	COG1285	pathogenesis
D0Z02_RS00915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0Z02_RS00930	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D0Z02_RS00945	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D0Z02_RS00960	COG2031	fatty acid transporter
D0Z02_RS00970	COG0786	glutamate:sodium symporter activity
D0Z02_RS00985	COG0463	Glycosyl transferase, family 2
D0Z02_RS00990	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D0Z02_RS01020	COG0697	spore germination
D0Z02_RS01035	COG3181	Tripartite tricarboxylate transporter family receptor
D0Z02_RS01060	COG0028	Belongs to the TPP enzyme family
D0Z02_RS01065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0Z02_RS01070	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0Z02_RS01070	COG1024	Enoyl-CoA hydratase
D0Z02_RS01075	COG3181	Tripartite tricarboxylate transporter family receptor
D0Z02_RS01085	COG0492	ferredoxin-NADP+ reductase activity
D0Z02_RS01105	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0Z02_RS01115	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0Z02_RS01140	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D0Z02_RS01160	COG2823	Periplasmic or secreted lipoprotein
D0Z02_RS01175	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D0Z02_RS01185	COG1309	transcriptional regulator
D0Z02_RS01190	COG0471	metal ion transport
D0Z02_RS01195	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D0Z02_RS01200	COG0772	Belongs to the SEDS family
D0Z02_RS01205	COG0768	penicillin binding
D0Z02_RS01215	COG1792	Involved in formation and maintenance of cell shape
D0Z02_RS01220	COG1077	Cell shape determining protein MreB Mrl
D0Z02_RS01225	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D0Z02_RS01240	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D0Z02_RS01245	COG0708	Exodeoxyribonuclease III
D0Z02_RS01250	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D0Z02_RS01255	COG2860	membrane
D0Z02_RS01290	COG1012	belongs to the aldehyde dehydrogenase family
D0Z02_RS01300	COG3069	C4-dicarboxylate transmembrane transporter activity
D0Z02_RS01310	COG1802	Transcriptional regulator
D0Z02_RS01345	COG1595	DNA-templated transcription, initiation
D0Z02_RS01350	COG3712	iron ion homeostasis
D0Z02_RS01360	COG3720	iron ion transport
D0Z02_RS01375	COG1120	ATPase activity
D0Z02_RS01380	COG1683	Conserved Protein
D0Z02_RS01410	COG3064	Membrane
D0Z02_RS01430	COG1234	tRNA 3'-trailer cleavage
D0Z02_RS01465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D0Z02_RS01475	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D0Z02_RS01490	COG0540	Belongs to the ATCase OTCase family
D0Z02_RS01495	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D0Z02_RS01500	COG1678	Uncharacterized ACR, COG1678
D0Z02_RS01515	COG0352	thiamine-phosphate diphosphorylase activity
D0Z02_RS01520	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D0Z02_RS01550	COG1024	Enoyl-CoA hydratase
D0Z02_RS01620	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
D0Z02_RS01630	COG0583	DNA-binding transcription factor activity
D0Z02_RS01635	COG2814	Major facilitator Superfamily
D0Z02_RS01640	COG0129	dihydroxy-acid dehydratase activity
D0Z02_RS01645	COG2207	Transcriptional regulator
D0Z02_RS01650	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D0Z02_RS01660	COG0657	acetylesterase activity
D0Z02_RS01665	COG0747	negative chemotaxis
D0Z02_RS01670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D0Z02_RS01675	COG2808	Putative FMN-binding domain
D0Z02_RS01690	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D0Z02_RS01695	COG1970	mechanosensitive ion channel activity
D0Z02_RS01700	COG0723	plastoquinol--plastocyanin reductase activity
D0Z02_RS01705	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D0Z02_RS01710	COG2857	Cytochrome c1
D0Z02_RS01715	COG0625	glutathione transferase activity
D0Z02_RS01720	COG2969	positive regulation of protein catabolic process
D0Z02_RS01785	COG1294	oxidase, subunit
D0Z02_RS01820	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0Z02_RS01825	COG0405	Gamma-glutamyltransferase
D0Z02_RS01835	COG3181	Tripartite tricarboxylate transporter family receptor
D0Z02_RS01845	COG0114	fumarate hydratase activity
D0Z02_RS01860	COG0586	Pfam SNARE associated Golgi protein
D0Z02_RS01870	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D0Z02_RS01875	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D0Z02_RS01890	COG0617	tRNA 3'-terminal CCA addition
D0Z02_RS01915	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D0Z02_RS01920	COG2188	Transcriptional regulator
D0Z02_RS01930	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D0Z02_RS01940	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z02_RS01975	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D0Z02_RS01980	COG1012	belongs to the aldehyde dehydrogenase family
D0Z02_RS02000	COG4257	antibiotic catabolic process
D0Z02_RS02010	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D0Z02_RS02015	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D0Z02_RS02030	COG2031	fatty acid transporter
D0Z02_RS02035	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z02_RS02040	COG1414	Transcriptional regulator
D0Z02_RS02050	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D0Z02_RS02065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D0Z02_RS02105	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D0Z02_RS02105	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D0Z02_RS02110	COG0509	glycine decarboxylation via glycine cleavage system
D0Z02_RS02115	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D0Z02_RS02125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D0Z02_RS02145	COG2081	HI0933 family
D0Z02_RS02175	COG0717	Belongs to the dCTP deaminase family
D0Z02_RS02190	COG0489	protein tyrosine kinase activity
D0Z02_RS02200	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0Z02_RS02200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0Z02_RS02205	COG1054	Belongs to the UPF0176 family
D0Z02_RS02245	COG1280	lysine exporter protein (LysE YggA)
D0Z02_RS02280	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D0Z02_RS02295	COG2226	methyltransferase
D0Z02_RS02300	COG0745	RESPONSE REGULATOR receiver
D0Z02_RS02305	COG5002	protein histidine kinase activity
D0Z02_RS02315	COG5002	protein histidine kinase activity
D0Z02_RS02325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D0Z02_RS02330	COG0583	DNA-binding transcription factor activity
D0Z02_RS02340	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D0Z02_RS02345	COG1984	allophanate hydrolase subunit 2
D0Z02_RS02375	COG1024	Enoyl-CoA hydratase
D0Z02_RS02390	COG1802	Transcriptional regulator
D0Z02_RS02405	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D0Z02_RS02425	COG0583	DNA-binding transcription factor activity
D0Z02_RS02435	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D0Z02_RS02445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D0Z02_RS02450	COG0154	amidase activity
D0Z02_RS02460	COG1609	Transcriptional regulator
D0Z02_RS02480	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D0Z02_RS02490	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D0Z02_RS02495	COG3842	ATPase activity
D0Z02_RS02500	COG1653	transport
D0Z02_RS02505	COG1175	transmembrane transport
D0Z02_RS02510	COG0395	ABC-type sugar transport system, permease component
D0Z02_RS02530	COG0018	arginyl-trna synthetase
D0Z02_RS02540	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D0Z02_RS02575	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D0Z02_RS02580	COG0321	lipoyl(octanoyl) transferase activity
D0Z02_RS02585	COG2921	Belongs to the UPF0250 family
D0Z02_RS02595	COG1686	Belongs to the peptidase S11 family
D0Z02_RS02615	COG1127	ABC transporter
D0Z02_RS02620	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D0Z02_RS02630	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D0Z02_RS02645	COG0859	PFAM glycosyl transferase family 9
D0Z02_RS02675	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D0Z02_RS02680	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D0Z02_RS02715	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D0Z02_RS02720	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D0Z02_RS02735	COG0625	glutathione transferase activity
D0Z02_RS02740	COG0326	Molecular chaperone. Has ATPase activity
D0Z02_RS02770	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D0Z02_RS02835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0Z02_RS02840	COG0765	amino acid transport
D0Z02_RS02845	COG0765	amino acid transport
D0Z02_RS02850	COG1126	abc transporter atp-binding protein
D0Z02_RS02865	COG2223	nitrite transmembrane transporter activity
D0Z02_RS02880	COG2813	Specifically methylates the guanine in position
D0Z02_RS02880	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D0Z02_RS02925	COG0242	peptide deformylase activity
D0Z02_RS02940	COG0204	Acyl-transferase
D0Z02_RS02945	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D0Z02_RS02950	COG0751	glycine-tRNA ligase activity
D0Z02_RS02975	COG1024	Enoyl-CoA hydratase
D0Z02_RS03000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0Z02_RS03040	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D0Z02_RS03045	COG0085	RNA polymerase activity
D0Z02_RS03050	COG0222	ribosome binding
D0Z02_RS03055	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D0Z02_RS03060	COG0081	regulation of translation
D0Z02_RS03065	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D0Z02_RS03075	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D0Z02_RS03085	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D0Z02_RS03110	COG1475	DNA binding
D0Z02_RS03120	COG1192	Involved in chromosome partitioning
D0Z02_RS03125	COG0357	Ribosomal RNA small subunit methyltransferase G
D0Z02_RS03130	COG0445	tRNA wobble uridine modification
D0Z02_RS03135	COG1278	Cold shock
D0Z02_RS03140	COG0436	Aminotransferase
D0Z02_RS03175	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D0Z02_RS03180	COG0747	negative chemotaxis
D0Z02_RS03195	COG0444	Belongs to the ABC transporter superfamily
D0Z02_RS03200	COG4608	Belongs to the ABC transporter superfamily
D0Z02_RS03205	COG1473	amidohydrolase
D0Z02_RS03210	COG2175	clavaminate synthase activity
D0Z02_RS03220	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D0Z02_RS03225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0Z02_RS03230	COG0753	catalase activity
D0Z02_RS03245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0Z02_RS03250	COG1024	Enoyl-CoA hydratase
D0Z02_RS03270	COG1024	Enoyl-CoA hydratase
D0Z02_RS03285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0Z02_RS03290	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0Z02_RS03305	COG2226	methyltransferase
D0Z02_RS03315	COG1194	a g-specific adenine glycosylase
D0Z02_RS03325	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D0Z02_RS03340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0Z02_RS03345	COG4597	amino acid ABC transporter
D0Z02_RS03350	COG0765	amino acid transport
D0Z02_RS03355	COG1126	abc transporter atp-binding protein
D0Z02_RS03370	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D0Z02_RS03375	COG0477	Major facilitator Superfamily
D0Z02_RS03385	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D0Z02_RS03390	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D0Z02_RS03405	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D0Z02_RS03410	COG0237	dephospho-CoA kinase activity
D0Z02_RS03415	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
D0Z02_RS03470	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D0Z02_RS03485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0Z02_RS03495	COG0747	negative chemotaxis
D0Z02_RS03500	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D0Z02_RS03520	COG0697	spore germination
D0Z02_RS03530	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
D0Z02_RS03535	COG2948	multi-organism process
D0Z02_RS03540	COG3504	Conjugal transfer protein
D0Z02_RS03545	COG3736	Type IV secretory pathway, component VirB8
D0Z02_RS03565	COG3702	type iv secretory pathway
D0Z02_RS03600	COG3181	Tripartite tricarboxylate transporter family receptor
D0Z02_RS03615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D0Z02_RS03620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D0Z02_RS03625	COG0537	adenosine 5'-monophosphoramidase activity
D0Z02_RS03630	COG0140	phosphoribosyl-ATP diphosphatase activity
D0Z02_RS03635	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D0Z02_RS03640	COG0107	imidazoleglycerol-phosphate synthase activity
D0Z02_RS03645	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D0Z02_RS03650	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D0Z02_RS03655	COG0131	Imidazoleglycerol-phosphate dehydratase
D0Z02_RS03660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D0Z02_RS03665	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D0Z02_RS03670	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D0Z02_RS03675	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D0Z02_RS03685	COG0842	Transport permease protein
D0Z02_RS03700	COG2853	Lipoprotein
D0Z02_RS03705	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D0Z02_RS03710	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D0Z02_RS03715	COG1127	ABC transporter
D0Z02_RS03725	COG3047	cAMP biosynthetic process
D0Z02_RS03735	COG0067	glutamate synthase
D0Z02_RS03735	COG0069	glutamate synthase activity
D0Z02_RS03735	COG0070	glutamate synthase
D0Z02_RS03745	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D0Z02_RS03750	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D0Z02_RS03765	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D0Z02_RS03785	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D0Z02_RS03825	COG0109	protoheme IX farnesyltransferase activity
D0Z02_RS03830	COG1999	signal sequence binding
D0Z02_RS03850	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D0Z02_RS03855	COG2814	Major facilitator Superfamily
D0Z02_RS03940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0Z02_RS03945	COG2816	NAD+ diphosphatase activity
D0Z02_RS03950	COG1309	transcriptional regulator
D0Z02_RS03955	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0Z02_RS03970	COG1024	Enoyl-CoA hydratase
D0Z02_RS03985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0Z02_RS04030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D0Z02_RS04060	COG1652	LysM domain
D0Z02_RS04075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D0Z02_RS04080	COG1956	GAF domain-containing protein
D0Z02_RS04085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0Z02_RS04110	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D0Z02_RS04135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0Z02_RS04155	COG0438	transferase activity, transferring glycosyl groups
D0Z02_RS04165	COG0402	S-adenosylhomocysteine deaminase activity
D0Z02_RS04205	COG0629	single-stranded DNA binding
D0Z02_RS04210	COG2814	Major facilitator Superfamily
D0Z02_RS04225	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D0Z02_RS04230	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D0Z02_RS04245	COG1965	Belongs to the frataxin family
D0Z02_RS04255	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D0Z02_RS04260	COG1333	cytochrome c biogenesis protein
D0Z02_RS04270	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D0Z02_RS04285	COG4232	protein-disulfide reductase activity
D0Z02_RS04290	COG1324	tolerance protein
D0Z02_RS04295	COG0537	adenosine 5'-monophosphoramidase activity
D0Z02_RS04300	COG0203	ribosomal protein L17
D0Z02_RS04305	COG0202	RNA polymerase activity
D0Z02_RS04310	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D0Z02_RS04315	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D0Z02_RS04320	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D0Z02_RS04325	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D0Z02_RS04330	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D0Z02_RS04335	COG0201	protein transport
D0Z02_RS04340	COG0200	Binds to the 23S rRNA
D0Z02_RS04345	COG1841	ribosomal large subunit assembly
D0Z02_RS04350	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D0Z02_RS04355	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D0Z02_RS04360	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D0Z02_RS04365	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D0Z02_RS04370	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D0Z02_RS04375	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D0Z02_RS04380	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D0Z02_RS04385	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D0Z02_RS04405	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D0Z02_RS04410	COG0255	Belongs to the universal ribosomal protein uL29 family
D0Z02_RS04415	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D0Z02_RS04420	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D0Z02_RS04425	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D0Z02_RS04430	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D0Z02_RS04435	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D0Z02_RS04440	COG0089	rRNA binding
D0Z02_RS04445	COG0088	Forms part of the polypeptide exit tunnel
D0Z02_RS04450	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D0Z02_RS04455	COG0051	transcription antitermination factor activity, RNA binding
D0Z02_RS04460	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D0Z02_RS04465	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D0Z02_RS04470	COG0049	tRNA binding
D0Z02_RS04475	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D0Z02_RS04500	COG0628	permease
D0Z02_RS04510	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D0Z02_RS04520	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D0Z02_RS04525	COG0351	phosphomethylpyrimidine kinase
D0Z02_RS04530	COG2022	thiamine diphosphate biosynthetic process
D0Z02_RS04535	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D0Z02_RS04540	COG4206	TonB-dependent receptor
D0Z02_RS04560	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D0Z02_RS04570	COG3781	membrane
D0Z02_RS04575	COG1522	sequence-specific DNA binding
D0Z02_RS04580	COG0028	Belongs to the TPP enzyme family
D0Z02_RS04590	COG1012	belongs to the aldehyde dehydrogenase family
D0Z02_RS04595	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z02_RS04600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0Z02_RS04605	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D0Z02_RS04630	COG2922	Belongs to the Smg family
D0Z02_RS04645	COG2358	TRAP transporter, solute receptor (TAXI family
D0Z02_RS04655	COG3181	Tripartite tricarboxylate transporter family receptor
D0Z02_RS04660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D0Z02_RS04675	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D0Z02_RS04680	COG0183	Belongs to the thiolase family
D0Z02_RS04730	COG1304	FMN binding
D0Z02_RS04745	COG0154	amidase activity
D0Z02_RS04750	COG1414	Transcriptional regulator
D0Z02_RS04765	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D0Z02_RS04770	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D0Z02_RS04775	COG0594	ribonuclease P activity
D0Z02_RS04780	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D0Z02_RS04785	COG0706	membrane insertase activity
D0Z02_RS04820	COG0582	viral genome integration into host DNA
D0Z02_RS04855	COG3723	Recombinational DNA repair protein, rece pathway
D0Z02_RS04905	COG0251	oxidation-reduction process
D0Z02_RS04915	COG0330	HflC and HflK could
D0Z02_RS04965	COG3181	Tripartite tricarboxylate transporter family receptor
D0Z02_RS04970	COG0318	PFAM AMP-dependent synthetase and ligase
D0Z02_RS04975	COG1414	Transcriptional regulator
D0Z02_RS04980	COG1024	Enoyl-CoA hydratase
D0Z02_RS04985	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D0Z02_RS05025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0Z02_RS05030	COG1942	4-Oxalocrotonate Tautomerase
D0Z02_RS05035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D0Z02_RS05055	COG0546	phosphoglycolate phosphatase activity
D0Z02_RS05065	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D0Z02_RS05080	COG0242	peptide deformylase activity
D0Z02_RS05090	COG1522	sequence-specific DNA binding
D0Z02_RS05110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0Z02_RS05115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0Z02_RS05135	COG0583	DNA-binding transcription factor activity
D0Z02_RS05165	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
D0Z02_RS05175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D0Z02_RS05175	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D0Z02_RS05185	COG5000	phosphorelay sensor kinase activity
D0Z02_RS05190	COG2204	response regulator
D0Z02_RS05225	COG3473	Maleate cis-trans isomerase
D0Z02_RS05235	COG2309	aminopeptidase activity
D0Z02_RS05240	COG1335	isochorismatase
D0Z02_RS05265	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D0Z02_RS05290	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D0Z02_RS05295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0Z02_RS05310	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D0Z02_RS05315	COG2226	methyltransferase
D0Z02_RS05335	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D0Z02_RS05340	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D0Z02_RS05345	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D0Z02_RS05350	COG1054	Belongs to the UPF0176 family
D0Z02_RS05355	COG0588	phosphoglycerate mutase activity
D0Z02_RS05360	COG4942	peptidase
D0Z02_RS05365	COG0793	Belongs to the peptidase S41A family
D0Z02_RS05370	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D0Z02_RS05400	COG3181	Tripartite tricarboxylate transporter family receptor
D0Z02_RS05415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0Z02_RS05425	COG0411	ABC transporter
D0Z02_RS05430	COG0559	Belongs to the binding-protein-dependent transport system permease family
D0Z02_RS05435	COG0683	leucine binding
D0Z02_RS05455	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0Z02_RS05460	COG1024	Enoyl-CoA hydratase
D0Z02_RS05465	COG0022	dehydrogenase e1 component
D0Z02_RS05470	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D0Z02_RS05490	COG1960	acyl-CoA dehydrogenase activity
D0Z02_RS05495	COG1024	Enoyl-CoA hydratase
D0Z02_RS05520	COG1960	acyl-CoA dehydrogenase activity
D0Z02_RS05525	COG3181	Tripartite tricarboxylate transporter family receptor
D0Z02_RS05530	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0Z02_RS05540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D0Z02_RS05575	COG0277	FAD linked oxidase domain protein
D0Z02_RS05580	COG1960	acyl-CoA dehydrogenase activity
D0Z02_RS05585	COG1960	acyl-CoA dehydrogenase activity
D0Z02_RS05595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0Z02_RS05615	COG0604	alcohol dehydrogenase
D0Z02_RS05650	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D0Z02_RS05655	COG1522	sequence-specific DNA binding
D0Z02_RS05660	COG0183	Belongs to the thiolase family
D0Z02_RS05670	COG1960	acyl-CoA dehydrogenase activity
D0Z02_RS05715	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D0Z02_RS05720	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D0Z02_RS05725	COG2890	protein-(glutamine-N5) methyltransferase activity
D0Z02_RS05730	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D0Z02_RS05740	COG3181	Tripartite tricarboxylate transporter family receptor
D0Z02_RS05780	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D0Z02_RS05795	COG2010	Cytochrome c
D0Z02_RS05795	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D0Z02_RS05800	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
D0Z02_RS05815	COG1137	ATPase activity
D0Z02_RS05830	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D0Z02_RS05840	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D0Z02_RS05875	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D0Z02_RS05880	COG3568	Endonuclease Exonuclease Phosphatase
D0Z02_RS05885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D0Z02_RS05915	COG0154	amidase activity
D0Z02_RS05925	COG1414	Transcriptional regulator
D0Z02_RS05935	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0Z02_RS05935	COG1024	Enoyl-CoA hydratase
D0Z02_RS05945	COG2132	Multicopper oxidase
D0Z02_RS06000	COG1024	Enoyl-CoA hydratase
D0Z02_RS06005	COG1024	Enoyl-CoA hydratase
D0Z02_RS06010	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D0Z02_RS06030	COG0601	transmembrane transport
D0Z02_RS06035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0Z02_RS06040	COG4172	Belongs to the ABC transporter superfamily
D0Z02_RS06050	COG2195	Cleaves the N-terminal amino acid of tripeptides
D0Z02_RS06060	COG0210	DNA helicase
D0Z02_RS06065	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D0Z02_RS06085	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D0Z02_RS06090	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D0Z02_RS06095	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D0Z02_RS06100	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D0Z02_RS06105	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D0Z02_RS06115	COG0356	it plays a direct role in the translocation of protons across the membrane
D0Z02_RS06140	COG1024	Enoyl-CoA hydratase
D0Z02_RS06150	COG3634	alkyl hydroperoxide reductase activity
D0Z02_RS06160	COG0037	tRNA processing
D0Z02_RS06170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D0Z02_RS06175	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D0Z02_RS06180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0Z02_RS06185	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D0Z02_RS06190	COG2967	ApaG domain
D0Z02_RS06195	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D0Z02_RS06200	COG0546	phosphoglycolate phosphatase activity
D0Z02_RS06210	COG0512	Glutamine amidotransferase of anthranilate synthase
D0Z02_RS06215	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D0Z02_RS06220	COG0134	indole-3-glycerol-phosphate synthase activity
D0Z02_RS06245	COG0583	DNA-binding transcription factor activity
D0Z02_RS06260	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D0Z02_RS06265	COG0259	pyridoxamine-phosphate oxidase activity
D0Z02_RS06275	COG2814	Major facilitator Superfamily
D0Z02_RS06280	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D0Z02_RS06285	COG2188	Transcriptional regulator
D0Z02_RS06290	COG0318	PFAM AMP-dependent synthetase and ligase
D0Z02_RS06310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D0Z02_RS06320	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D0Z02_RS06335	COG1215	transferase activity, transferring glycosyl groups
D0Z02_RS06345	COG0601	transmembrane transport
D0Z02_RS06380	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D0Z02_RS06385	COG2894	cell division
D0Z02_RS06390	COG0850	regulation of cytokinetic process
D0Z02_RS06395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D0Z02_RS06435	COG2979	Protein of unknown function (DUF533)
D0Z02_RS06455	COG1388	LysM domain
D0Z02_RS06455	COG0741	lytic transglycosylase activity
D0Z02_RS06460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0Z02_RS06465	COG2226	methyltransferase
D0Z02_RS06470	COG0328	RNA-DNA hybrid ribonuclease activity
D0Z02_RS06570	COG1960	acyl-CoA dehydrogenase activity
D0Z02_RS06585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0Z02_RS06605	COG2718	Belongs to the UPF0229 family
D0Z02_RS06610	COG2719	SpoVR family
D0Z02_RS06635	COG2188	Transcriptional regulator
D0Z02_RS06660	COG0829	nickel cation binding
D0Z02_RS06665	COG0831	urea catabolic process
D0Z02_RS06675	COG0832	Belongs to the urease beta subunit family
D0Z02_RS06690	COG0830	nickel cation binding
D0Z02_RS06695	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D0Z02_RS06715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0Z02_RS06720	COG0601	transmembrane transport
D0Z02_RS06725	COG0747	negative chemotaxis
D0Z02_RS06735	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D0Z02_RS06740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0Z02_RS06750	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D0Z02_RS06760	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
D0Z02_RS06765	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D0Z02_RS06770	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D0Z02_RS06785	COG0438	transferase activity, transferring glycosyl groups
D0Z02_RS06805	COG0438	transferase activity, transferring glycosyl groups
D0Z02_RS06810	COG0166	Belongs to the GPI family
D0Z02_RS06825	COG0277	FAD linked oxidase domain protein
D0Z02_RS06830	COG0745	RESPONSE REGULATOR receiver
D0Z02_RS06835	COG0642	Histidine kinase
D0Z02_RS06840	COG1368	sulfuric ester hydrolase activity
D0Z02_RS06875	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D0Z02_RS06885	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
D0Z02_RS06890	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D0Z02_RS06900	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D0Z02_RS06905	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D0Z02_RS06910	COG0193	aminoacyl-tRNA hydrolase activity
D0Z02_RS06920	COG0012	GTP binding
D0Z02_RS06925	COG0582	viral genome integration into host DNA
D0Z02_RS06950	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D0Z02_RS07010	COG0745	RESPONSE REGULATOR receiver
D0Z02_RS07025	COG1309	transcriptional regulator
D0Z02_RS07055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0Z02_RS07065	COG0405	Gamma-glutamyltransferase
D0Z02_RS07140	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D0Z02_RS07145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D0Z02_RS07155	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D0Z02_RS07170	COG0617	tRNA 3'-terminal CCA addition
D0Z02_RS07185	COG0477	Major facilitator Superfamily
D0Z02_RS07195	COG0583	DNA-binding transcription factor activity
D0Z02_RS07210	COG1950	PFAM Membrane protein of
D0Z02_RS07215	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D0Z02_RS07230	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D0Z02_RS07240	COG1560	Kdo2-lipid A biosynthetic process
D0Z02_RS07245	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D0Z02_RS07265	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
D0Z02_RS07275	COG0803	Belongs to the bacterial solute-binding protein 9 family
D0Z02_RS07295	COG0735	belongs to the Fur family
D0Z02_RS07300	COG0523	cobalamin synthesis protein
D0Z02_RS07310	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D0Z02_RS07315	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D0Z02_RS07330	COG2096	Adenosyltransferase
D0Z02_RS07350	COG2084	Dehydrogenase
D0Z02_RS07405	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D0Z02_RS07415	COG4654	Cytochrome c, class I
D0Z02_RS07420	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0Z02_RS07470	COG1473	amidohydrolase
D0Z02_RS07475	COG0418	dihydroorotase activity
D0Z02_RS07490	COG2001	Belongs to the MraZ family
D0Z02_RS07500	COG3116	cell division
D0Z02_RS07510	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D0Z02_RS07515	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D0Z02_RS07520	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D0Z02_RS07530	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D0Z02_RS07535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D0Z02_RS07540	COG1181	Belongs to the D-alanine--D-alanine ligase family
D0Z02_RS07545	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D0Z02_RS07555	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D0Z02_RS07560	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D0Z02_RS07570	COG0739	heme binding
D0Z02_RS07575	COG0653	protein targeting
D0Z02_RS07595	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z02_RS07600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0Z02_RS07605	COG1522	sequence-specific DNA binding
D0Z02_RS07640	COG3150	esterase
D0Z02_RS07645	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D0Z02_RS07650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0Z02_RS07655	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D0Z02_RS07660	COG0511	ligase activity, forming carbon-carbon bonds
D0Z02_RS07665	COG0439	Biotin carboxylase
D0Z02_RS07680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0Z02_RS07705	COG1696	Membrane protein involved in D-alanine export
D0Z02_RS07710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0Z02_RS07745	COG1522	sequence-specific DNA binding
D0Z02_RS07760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D0Z02_RS07780	COG1802	Transcriptional regulator
D0Z02_RS07785	COG3069	C4-dicarboxylate transmembrane transporter activity
D0Z02_RS07795	COG0346	lactoylglutathione lyase activity
D0Z02_RS07800	COG1335	isochorismatase
D0Z02_RS07805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0Z02_RS07810	COG1116	anion transmembrane transporter activity
D0Z02_RS07825	COG3028	Belongs to the UPF0307 family
D0Z02_RS07830	COG0312	modulator of DNA gyrase
D0Z02_RS07835	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D0Z02_RS07840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D0Z02_RS07845	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D0Z02_RS07850	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D0Z02_RS07860	COG0316	Belongs to the HesB IscA family
D0Z02_RS07865	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D0Z02_RS07880	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D0Z02_RS07890	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D0Z02_RS07895	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D0Z02_RS07910	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D0Z02_RS07910	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D0Z02_RS07950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0Z02_RS07985	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D0Z02_RS07995	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D0Z02_RS08000	COG1845	cytochrome c oxidase, subunit III
D0Z02_RS08005	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D0Z02_RS08010	COG0640	Transcriptional regulator
D0Z02_RS08030	COG3220	belongs to the UPF0276 family
D0Z02_RS08075	COG1666	GTP binding
D0Z02_RS08115	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D0Z02_RS08120	COG3210	domain, Protein
D0Z02_RS08120	COG3210	domain, Protein
D0Z02_RS08120	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
D0Z02_RS08120	COG3064	Membrane
D0Z02_RS08120	COG3064	Membrane
D0Z02_RS08120	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
D0Z02_RS08125	COG0277	FAD linked oxidase domain protein
D0Z02_RS08130	COG0277	FAD linked oxidase domain protein
D0Z02_RS08135	COG0277	FAD linked oxidase domain protein
D0Z02_RS08140	COG0247	lactate metabolic process
D0Z02_RS08145	COG2819	hydrolase of the alpha beta superfamily
D0Z02_RS08185	COG0583	DNA-binding transcription factor activity
D0Z02_RS08190	COG0482	sulfurtransferase activity
D0Z02_RS08195	COG0730	response to heat
D0Z02_RS08200	COG0625	glutathione transferase activity
D0Z02_RS08210	COG3909	cytochrome
D0Z02_RS08250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0Z02_RS08255	COG1024	Enoyl-CoA hydratase
D0Z02_RS08270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0Z02_RS08285	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z02_RS08290	COG1414	Transcriptional regulator
D0Z02_RS08305	COG0251	oxidation-reduction process
D0Z02_RS08310	COG0559	Belongs to the binding-protein-dependent transport system permease family
D0Z02_RS08345	COG0583	DNA-binding transcription factor activity
D0Z02_RS08355	COG0590	tRNA wobble adenosine to inosine editing
D0Z02_RS08360	COG2807	transmembrane transport
D0Z02_RS08380	COG0154	amidase activity
D0Z02_RS08385	COG0307	riboflavin synthase, alpha
D0Z02_RS08390	COG3181	Tripartite tricarboxylate transporter family receptor
D0Z02_RS08395	COG1522	sequence-specific DNA binding
D0Z02_RS08405	COG0318	PFAM AMP-dependent synthetase and ligase
D0Z02_RS08415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0Z02_RS08435	COG1063	alcohol dehydrogenase
D0Z02_RS08460	COG1418	mRNA catabolic process
D0Z02_RS08465	COG1448	Aminotransferase
D0Z02_RS08470	COG0583	DNA-binding transcription factor activity
D0Z02_RS08480	COG0477	Major facilitator Superfamily
D0Z02_RS08485	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z02_RS08500	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D0Z02_RS08505	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D0Z02_RS08510	COG0583	DNA-binding transcription factor activity
D0Z02_RS08570	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z02_RS08575	COG1309	transcriptional regulator
D0Z02_RS08585	COG2982	Protein involved in outer membrane biogenesis
D0Z02_RS08590	COG2818	Glycosylase
D0Z02_RS08610	COG1653	transport
D0Z02_RS08625	COG3842	ATPase activity
D0Z02_RS08630	COG0395	ABC-type sugar transport system, permease component
D0Z02_RS08635	COG1175	transmembrane transport
D0Z02_RS08650	COG3181	Tripartite tricarboxylate transporter family receptor
D0Z02_RS08655	COG2186	Transcriptional regulator
D0Z02_RS08705	COG2011	ABC-type metal ion transport system permease component
D0Z02_RS08710	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D0Z02_RS08715	COG1501	Belongs to the glycosyl hydrolase 31 family
D0Z02_RS08740	COG0318	PFAM AMP-dependent synthetase and ligase
D0Z02_RS08745	COG1473	amidohydrolase
D0Z02_RS08755	COG2855	membrane
D0Z02_RS08765	COG2239	Acts as a magnesium transporter
D0Z02_RS08785	COG3181	Tripartite tricarboxylate transporter family receptor
D0Z02_RS08795	COG1722	exodeoxyribonuclease VII activity
D0Z02_RS08805	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D0Z02_RS08810	COG1469	GTP cyclohydrolase I activity
D0Z02_RS08815	COG0360	Binds together with S18 to 16S ribosomal RNA
D0Z02_RS08820	COG2965	DNA replication, synthesis of RNA primer
D0Z02_RS08825	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D0Z02_RS08830	COG0359	binds to the 23S rRNA
D0Z02_RS08840	COG0305	Participates in initiation and elongation during chromosome replication
D0Z02_RS08850	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D0Z02_RS08860	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D0Z02_RS08865	COG3737	Protein of unknown function (DUF498/DUF598)
D0Z02_RS08870	COG0436	Aminotransferase
D0Z02_RS08895	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D0Z02_RS08930	COG0268	Binds directly to 16S ribosomal RNA
D0Z02_RS08950	COG0563	adenylate kinase activity
D0Z02_RS08955	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D0Z02_RS08960	COG2835	tetraacyldisaccharide 4'-kinase activity
D0Z02_RS08965	COG1663	tetraacyldisaccharide 4'-kinase activity
D0Z02_RS08970	COG0848	biopolymer transport protein
D0Z02_RS08975	COG0811	peptide transport
D0Z02_RS08985	COG1570	exodeoxyribonuclease VII activity
D0Z02_RS08990	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D0Z02_RS08995	COG0038	chloride channel
D0Z02_RS09000	COG0183	Belongs to the thiolase family
D0Z02_RS09010	COG1278	Cold shock
D0Z02_RS09015	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D0Z02_RS09025	COG4953	penicillin-binding protein 1C
D0Z02_RS09030	COG0542	response to heat
D0Z02_RS09035	COG2995	paraquat-inducible protein a
D0Z02_RS09040	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D0Z02_RS09040	COG3008	intermembrane lipid transfer
D0Z02_RS09050	COG0506	proline dehydrogenase activity
D0Z02_RS09050	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D0Z02_RS09050	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D0Z02_RS09085	COG2271	Major facilitator Superfamily
D0Z02_RS09090	COG1309	transcriptional regulator
D0Z02_RS09125	COG0477	Major facilitator Superfamily
D0Z02_RS09135	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D0Z02_RS09140	COG1845	cytochrome c oxidase, subunit III
D0Z02_RS09145	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D0Z02_RS09155	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z02_RS09175	COG0789	Transcriptional regulator
D0Z02_RS09200	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D0Z02_RS09205	COG0697	spore germination
D0Z02_RS09215	COG0678	peroxiredoxin activity
D0Z02_RS09225	COG0412	Dienelactone hydrolase
D0Z02_RS09235	COG0315	cyclic pyranopterin monophosphate synthase activity
D0Z02_RS09250	COG0521	Mo-molybdopterin cofactor biosynthetic process
D0Z02_RS09255	COG0303	'Molybdopterin
D0Z02_RS09260	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D0Z02_RS09280	COG0165	Argininosuccinate lyase
D0Z02_RS09285	COG0668	transmembrane transport
D0Z02_RS09330	COG0747	negative chemotaxis
D0Z02_RS09335	COG0601	transmembrane transport
D0Z02_RS09350	COG1162	GTPase activity
D0Z02_RS09355	COG0501	Belongs to the peptidase M48B family
D0Z02_RS09375	COG3396	Phenylacetate-CoA oxygenase
D0Z02_RS09380	COG3460	Phenylacetate-CoA oxygenase
D0Z02_RS09385	COG3396	Phenylacetate-CoA oxygenase
D0Z02_RS09390	COG2151	metal-sulfur cluster biosynthetic enzyme
D0Z02_RS09410	COG1012	belongs to the aldehyde dehydrogenase family
D0Z02_RS09415	COG1024	Enoyl-CoA hydratase
D0Z02_RS09420	COG2050	protein possibly involved in aromatic compounds catabolism
D0Z02_RS09430	COG3539	Fimbrial protein
D0Z02_RS09450	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D0Z02_RS09455	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D0Z02_RS09455	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D0Z02_RS09460	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D0Z02_RS09465	COG0047	phosphoribosylformylglycinamidine synthase activity
D0Z02_RS09465	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D0Z02_RS09500	COG0235	Class ii aldolase
D0Z02_RS09505	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D0Z02_RS09510	COG0720	synthase
D0Z02_RS09515	COG0602	queuosine metabolic process
D0Z02_RS09540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D0Z02_RS09575	COG3181	Tripartite tricarboxylate transporter family receptor
D0Z02_RS09600	COG3842	ATPase activity
D0Z02_RS09610	COG0395	ABC-type sugar transport system, permease component
D0Z02_RS09640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0Z02_RS09645	COG0420	3'-5' exonuclease activity
D0Z02_RS09690	COG0519	Catalyzes the synthesis of GMP from XMP
D0Z02_RS09690	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D0Z02_RS09740	COG1116	anion transmembrane transporter activity
D0Z02_RS09745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0Z02_RS09780	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D0Z02_RS09795	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D0Z02_RS09825	COG2814	Major facilitator Superfamily
D0Z02_RS09855	COG0747	negative chemotaxis
D0Z02_RS09860	COG0601	transmembrane transport
D0Z02_RS09865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0Z02_RS09870	COG4172	Belongs to the ABC transporter superfamily
D0Z02_RS09875	COG1609	Transcriptional regulator
D0Z02_RS09905	COG0586	Pfam SNARE associated Golgi protein
D0Z02_RS09920	COG0500	methyltransferase
D0Z02_RS09935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0Z02_RS09945	COG0756	dUTP diphosphatase activity
D0Z02_RS09960	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D0Z02_RS09965	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D0Z02_RS09970	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D0Z02_RS09975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0Z02_RS09975	COG0072	phenylalanine-tRNA ligase activity
D0Z02_RS09980	COG0776	regulation of translation
D0Z02_RS10045	COG0540	Belongs to the ATCase OTCase family
D0Z02_RS10050	COG2974	May be involved in recombination
D0Z02_RS10060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0Z02_RS10065	COG0583	DNA-binding transcription factor activity
D0Z02_RS10085	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z02_RS10100	COG3842	ATPase activity
D0Z02_RS10105	COG1024	Enoyl-CoA hydratase
D0Z02_RS10105	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0Z02_RS10125	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D0Z02_RS10130	COG2137	regulation of response to DNA damage stimulus
D0Z02_RS10150	COG0045	succinate-CoA ligase (ADP-forming) activity
D0Z02_RS10155	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D0Z02_RS10160	COG0861	Integral membrane protein TerC family
D0Z02_RS10170	COG0181	hydroxymethylbilane synthase activity
D0Z02_RS10260	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D0Z02_RS10270	COG0583	DNA-binding transcription factor activity
D0Z02_RS10280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0Z02_RS10285	COG4311	Sarcosine oxidase, delta subunit
D0Z02_RS10290	COG0446	pyridine nucleotide-disulphide oxidoreductase
D0Z02_RS10290	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D0Z02_RS10325	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D0Z02_RS10330	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D0Z02_RS10335	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0Z02_RS10340	COG0735	belongs to the Fur family
D0Z02_RS10345	COG0497	DNA recombination
D0Z02_RS10350	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D0Z02_RS10355	COG1420	regulation of RNA biosynthetic process
D0Z02_RS10360	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D0Z02_RS10380	COG0443	Heat shock 70 kDa protein
D0Z02_RS10390	COG0612	Peptidase, M16
D0Z02_RS10455	COG0745	RESPONSE REGULATOR receiver
D0Z02_RS10465	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D0Z02_RS10475	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D0Z02_RS10490	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0Z02_RS10505	COG1193	negative regulation of DNA recombination
D0Z02_RS10510	COG0492	ferredoxin-NADP+ reductase activity
D0Z02_RS10515	COG1674	ftsk spoiiie
D0Z02_RS10520	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D0Z02_RS10525	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D0Z02_RS10530	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D0Z02_RS10555	COG3706	GGDEF domain
D0Z02_RS10575	COG2814	Major facilitator Superfamily
D0Z02_RS10605	COG3486	L-lysine 6-monooxygenase (NADPH) activity
D0Z02_RS10620	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z02_RS10630	COG3022	response to hydroperoxide
D0Z02_RS10645	COG3023	N-Acetylmuramoyl-L-alanine amidase
D0Z02_RS10655	COG0424	maF-like protein
D0Z02_RS10660	COG1399	metal-binding, possibly nucleic acid-binding protein
D0Z02_RS10665	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D0Z02_RS10670	COG0416	fatty acid biosynthetic process
D0Z02_RS10675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D0Z02_RS10690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0Z02_RS10695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D0Z02_RS10720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0Z02_RS10725	COG0481	GTPase activity
D0Z02_RS10730	COG0681	Belongs to the peptidase S26 family
D0Z02_RS10735	COG0571	ribonuclease III activity
D0Z02_RS10740	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D0Z02_RS10745	COG1381	Involved in DNA repair and RecF pathway recombination
D0Z02_RS10780	COG0670	Belongs to the BI1 family
D0Z02_RS10805	COG0583	DNA-binding transcription factor activity
D0Z02_RS10835	COG0791	NLP P60 protein
D0Z02_RS10845	COG3193	protein, possibly involved in utilization of glycolate and propanediol
D0Z02_RS10855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D0Z02_RS10860	COG0697	spore germination
D0Z02_RS10880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D0Z02_RS10910	COG1446	asparaginase
D0Z02_RS10915	COG4172	Belongs to the ABC transporter superfamily
D0Z02_RS10920	COG0747	negative chemotaxis
D0Z02_RS10930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0Z02_RS10960	COG0504	CTP synthase activity
D0Z02_RS10975	COG0148	phosphopyruvate hydratase activity
D0Z02_RS10980	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D0Z02_RS11010	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D0Z02_RS11045	COG1981	membrane
D0Z02_RS11080	COG2188	Transcriptional regulator
D0Z02_RS11085	COG2009	succinate dehydrogenase
D0Z02_RS11090	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
D0Z02_RS11100	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D0Z02_RS11105	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D0Z02_RS11110	COG0372	Belongs to the citrate synthase family
D0Z02_RS11125	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D0Z02_RS11125	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D0Z02_RS11135	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D0Z02_RS11155	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D0Z02_RS11160	COG3842	ATPase activity
D0Z02_RS11165	COG1176	ABC-type spermidine putrescine transport system, permease component I
D0Z02_RS11170	COG1177	transmembrane transport
D0Z02_RS11195	COG1960	acyl-CoA dehydrogenase activity
D0Z02_RS11200	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D0Z02_RS11205	COG0704	Plays a role in the regulation of phosphate uptake
D0Z02_RS11215	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D0Z02_RS11220	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D0Z02_RS11220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D0Z02_RS11240	COG0438	transferase activity, transferring glycosyl groups
D0Z02_RS11245	COG0726	polysaccharide deacetylase
D0Z02_RS11250	COG0463	Glycosyl transferase, family 2
D0Z02_RS11255	COG0438	transferase activity, transferring glycosyl groups
D0Z02_RS11300	COG1132	(ABC) transporter
D0Z02_RS11315	COG0077	Prephenate dehydratase
D0Z02_RS11360	COG3468	outer membrane autotransporter barrel domain protein
D0Z02_RS11365	COG0424	maF-like protein
D0Z02_RS11375	COG0799	negative regulation of ribosome biogenesis
D0Z02_RS11380	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D0Z02_RS11385	COG0408	coproporphyrinogen oxidase activity
D0Z02_RS11390	COG0151	Belongs to the GarS family
D0Z02_RS11395	COG0217	transcriptional regulatory protein
D0Z02_RS11410	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D0Z02_RS11420	COG1012	belongs to the aldehyde dehydrogenase family
D0Z02_RS11445	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D0Z02_RS11460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0Z02_RS11470	COG0747	negative chemotaxis
D0Z02_RS11485	COG2814	Major facilitator Superfamily
D0Z02_RS11490	COG1566	PFAM secretion protein HlyD family protein
D0Z02_RS11500	COG1846	Transcriptional regulator
D0Z02_RS11510	COG0697	spore germination
D0Z02_RS11520	COG0501	Belongs to the peptidase M48B family
D0Z02_RS11540	COG0583	DNA-binding transcription factor activity
D0Z02_RS11545	COG3842	ATPase activity
D0Z02_RS11555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0Z02_RS11560	COG1840	ABC-type Fe3 transport system, periplasmic component
D0Z02_RS11585	COG2233	PERMEase
D0Z02_RS11590	COG0840	transmembrane signaling receptor activity
D0Z02_RS11595	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0Z02_RS11630	COG4789	Type iii secretion
D0Z02_RS11695	COG4669	(LipO)protein
D0Z02_RS11730	COG4790	Type iii secretion
D0Z02_RS11735	COG4794	Type iii secretion
D0Z02_RS11740	COG4791	protein targeting
D0Z02_RS11745	COG4792	protein secretion
D0Z02_RS11760	COG1595	DNA-templated transcription, initiation
D0Z02_RS11780	COG2770	Histidine kinase
D0Z02_RS11780	COG2208	phosphoserine phosphatase activity
D0Z02_RS11790	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D0Z02_RS11795	COG2172	sigma factor antagonist activity
D0Z02_RS11800	COG1366	Belongs to the anti-sigma-factor antagonist family
D0Z02_RS11805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D0Z02_RS11840	COG2358	TRAP transporter, solute receptor (TAXI family
D0Z02_RS11845	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D0Z02_RS11875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0Z02_RS11885	COG2252	PERMEase
D0Z02_RS11890	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D0Z02_RS11900	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D0Z02_RS11905	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D0Z02_RS11935	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D0Z02_RS11940	COG0789	Transcriptional regulator
D0Z02_RS11950	COG0678	peroxiredoxin activity
D0Z02_RS11950	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D0Z02_RS11960	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D0Z02_RS11965	COG0584	glycerophosphoryl diester phosphodiesterase
D0Z02_RS11980	COG4181	ATPase activity
D0Z02_RS11995	COG2823	Periplasmic or secreted lipoprotein
D0Z02_RS12005	COG3237	CsbD-like
D0Z02_RS12010	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D0Z02_RS12010	COG1181	Belongs to the D-alanine--D-alanine ligase family
D0Z02_RS12015	COG0189	ligase activity
D0Z02_RS12015	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D0Z02_RS12035	COG2833	Protein of unknown function (DUF455)
D0Z02_RS12060	COG1522	sequence-specific DNA binding
D0Z02_RS12075	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D0Z02_RS12085	COG0196	riboflavin kinase activity
D0Z02_RS12090	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D0Z02_RS12110	COG0210	DNA helicase
D0Z02_RS12115	COG4771	TonB-dependent receptor
D0Z02_RS12120	COG0488	(ABC) transporter
D0Z02_RS12125	COG2890	protein-(glutamine-N5) methyltransferase activity
D0Z02_RS12130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0Z02_RS12135	COG2171	N-acyltransferase activity
D0Z02_RS12170	COG1278	Cold shock
D0Z02_RS12180	COG1278	Cold shock
D0Z02_RS12190	COG0544	peptidyl-prolyl cis-trans isomerase activity
D0Z02_RS12195	COG0740	serine-type endopeptidase activity
D0Z02_RS12200	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D0Z02_RS12205	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D0Z02_RS12215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0Z02_RS12230	COG1024	Enoyl-CoA hydratase
D0Z02_RS12240	COG0183	Belongs to the thiolase family
D0Z02_RS12245	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z02_RS12265	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D0Z02_RS12295	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D0Z02_RS12305	COG0556	nucleotide-excision repair
D0Z02_RS12310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D0Z02_RS12320	COG1104	cysteine desulfurase activity
D0Z02_RS12325	COG0822	iron-sulfur transferase activity
D0Z02_RS12330	COG0316	Belongs to the HesB IscA family
D0Z02_RS12335	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D0Z02_RS12345	COG0633	Ferredoxin
D0Z02_RS12365	COG1024	Enoyl-CoA hydratase
D0Z02_RS12380	COG3395	kinase activity
D0Z02_RS12400	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D0Z02_RS12410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0Z02_RS12440	COG0747	negative chemotaxis
D0Z02_RS12445	COG0601	transmembrane transport
D0Z02_RS12450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0Z02_RS12455	COG4172	Belongs to the ABC transporter superfamily
D0Z02_RS12505	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D0Z02_RS12510	COG0425	Belongs to the sulfur carrier protein TusA family
D0Z02_RS12520	COG0228	four-way junction DNA binding
D0Z02_RS12525	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D0Z02_RS12530	COG0336	Belongs to the RNA methyltransferase TrmD family
D0Z02_RS12535	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D0Z02_RS12560	COG0642	Histidine kinase
D0Z02_RS12575	COG0525	valine-tRNA ligase activity
D0Z02_RS12580	COG0105	UTP biosynthetic process
D0Z02_RS12585	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D0Z02_RS12595	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D0Z02_RS12600	COG0124	histidyl-tRNA synthetase
D0Z02_RS12605	COG2976	Protein conserved in bacteria
D0Z02_RS12610	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0Z02_RS12615	COG1160	GTP binding
D0Z02_RS12620	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D0Z02_RS12625	COG1923	regulation of RNA biosynthetic process
D0Z02_RS12630	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D0Z02_RS12640	COG0330	HflC and HflK could
D0Z02_RS12645	COG0330	HflC and HflK could
D0Z02_RS12650	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D0Z02_RS12655	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D0Z02_RS12660	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D0Z02_RS12665	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D0Z02_RS12675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D0Z02_RS12710	COG0628	permease
D0Z02_RS12715	COG0842	Transport permease protein
D0Z02_RS12720	COG1131	(ABC) transporter
D0Z02_RS12805	COG0156	8-amino-7-oxononanoate synthase activity
D0Z02_RS12815	COG4106	trans-aconitate 2-methyltransferase activity
D0Z02_RS12815	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D0Z02_RS12820	COG1380	Effector of murein hydrolase LrgA
D0Z02_RS12860	COG1012	belongs to the aldehyde dehydrogenase family
D0Z02_RS12875	COG2733	membrane
D0Z02_RS12880	COG0583	DNA-binding transcription factor activity
D0Z02_RS12890	COG5507	3-demethylubiquinone-9 3-methyltransferase
D0Z02_RS12895	COG2169	Transcriptional regulator
D0Z02_RS12925	COG0659	secondary active sulfate transmembrane transporter activity
D0Z02_RS12950	COG1132	(ABC) transporter
D0Z02_RS13000	COG2207	Transcriptional regulator
D0Z02_RS13140	COG2346	COG2346, Truncated hemoglobins
D0Z02_RS13170	COG0583	DNA-binding transcription factor activity
D0Z02_RS13200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0Z02_RS13205	COG0633	Ferredoxin
D0Z02_RS13215	COG1024	Enoyl-CoA hydratase
D0Z02_RS13225	COG4638	Rieske (2fe-2S)
D0Z02_RS13255	COG2224	Isocitrate lyase
D0Z02_RS13260	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D0Z02_RS13260	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D0Z02_RS13270	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D0Z02_RS13280	COG1472	Belongs to the glycosyl hydrolase 3 family
D0Z02_RS13285	COG0736	holo-[acyl-carrier-protein] synthase activity
D0Z02_RS13290	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D0Z02_RS13305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0Z02_RS13330	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
D0Z02_RS13345	COG2032	superoxide dismutase activity
D0Z02_RS13360	COG1024	Enoyl-CoA hydratase
D0Z02_RS13370	COG1802	Transcriptional regulator
D0Z02_RS13380	COG0183	Belongs to the thiolase family
D0Z02_RS13385	COG1942	4-Oxalocrotonate Tautomerase
D0Z02_RS13395	COG4176	ABC-type proline glycine betaine transport system permease component
D0Z02_RS13415	COG2814	Major facilitator Superfamily
D0Z02_RS13420	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D0Z02_RS13425	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D0Z02_RS13460	COG2814	Major facilitator Superfamily
D0Z02_RS13465	COG0495	leucyl-tRNA aminoacylation
D0Z02_RS13480	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D0Z02_RS13490	COG0154	amidase activity
D0Z02_RS13495	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0Z02_RS13555	COG0583	DNA-binding transcription factor activity
D0Z02_RS13575	COG0730	response to heat
D0Z02_RS13580	COG0697	spore germination
D0Z02_RS13615	COG2885	chlorophyll binding
D0Z02_RS13650	COG3384	dioxygenase
D0Z02_RS13665	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D0Z02_RS13670	COG3474	cytochrome
D0Z02_RS13680	COG1595	DNA-templated transcription, initiation
D0Z02_RS13695	COG2204	response regulator
D0Z02_RS13735	COG4964	Belongs to the GSP D family
D0Z02_RS13790	COG1846	Transcriptional regulator
D0Z02_RS13795	COG4172	Belongs to the ABC transporter superfamily
D0Z02_RS13800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0Z02_RS13805	COG0601	transmembrane transport
D0Z02_RS13810	COG0747	negative chemotaxis
D0Z02_RS13820	COG0598	Magnesium transport protein CorA
D0Z02_RS13825	COG0210	DNA helicase
D0Z02_RS13845	COG1012	belongs to the aldehyde dehydrogenase family
D0Z02_RS13855	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D0Z02_RS13870	COG0166	Belongs to the GPI family
D0Z02_RS13885	COG2197	response regulator
D0Z02_RS13895	COG1846	Transcriptional regulator
D0Z02_RS13920	COG1215	transferase activity, transferring glycosyl groups
D0Z02_RS13930	COG1902	pentaerythritol trinitrate reductase activity
D0Z02_RS13955	COG0251	oxidation-reduction process
D0Z02_RS13965	COG1832	CoA-binding protein
D0Z02_RS13970	COG1414	Transcriptional regulator
D0Z02_RS13985	COG3842	ATPase activity
D0Z02_RS14010	COG0583	DNA-binding transcription factor activity
D0Z02_RS14025	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
D0Z02_RS14045	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D0Z02_RS14045	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D0Z02_RS14050	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0Z02_RS14075	COG0527	aspartate kinase activity
D0Z02_RS14090	COG0825	malonyl-CoA metabolic process
D0Z02_RS14100	COG0215	cysteine-tRNA ligase activity
D0Z02_RS14115	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D0Z02_RS14120	COG1968	undecaprenyl-diphosphatase activity
D0Z02_RS14125	COG1253	flavin adenine dinucleotide binding
D0Z02_RS14130	COG0483	inositol monophosphate 1-phosphatase activity
D0Z02_RS14150	COG0668	transmembrane transport
D0Z02_RS14200	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D0Z02_RS14220	COG3539	Fimbrial protein
D0Z02_RS14225	COG3188	usher protein
D0Z02_RS14230	COG3121	Chaperone
D0Z02_RS14245	COG2197	response regulator
D0Z02_RS14260	COG4336	lyase activity
D0Z02_RS14310	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D0Z02_RS14320	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D0Z02_RS14320	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D0Z02_RS14330	COG0028	Belongs to the TPP enzyme family
D0Z02_RS14345	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D0Z02_RS14355	COG1126	abc transporter atp-binding protein
D0Z02_RS14365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0Z02_RS14380	COG0084	hydrolase, TatD family'
D0Z02_RS14385	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D0Z02_RS14390	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D0Z02_RS14395	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D0Z02_RS14420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0Z02_RS14425	COG1959	2 iron, 2 sulfur cluster binding
D0Z02_RS14430	COG1017	nitric oxide dioxygenase activity
D0Z02_RS14430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0Z02_RS14465	COG0488	(ABC) transporter
D0Z02_RS14470	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D0Z02_RS14485	COG1024	Enoyl-CoA hydratase
D0Z02_RS14490	COG1619	proteins homologs of microcin C7 resistance protein MccF
D0Z02_RS14495	COG0590	tRNA wobble adenosine to inosine editing
D0Z02_RS14520	COG2212	antiporter activity
D0Z02_RS14525	COG1863	multisubunit Na H antiporter MnhE subunit
D0Z02_RS14535	COG1006	Multisubunit Na H antiporter MnhC subunit
D0Z02_RS14540	COG2111	Na H antiporter
D0Z02_RS14540	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D0Z02_RS14560	COG0583	DNA-binding transcription factor activity
D0Z02_RS14565	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z02_RS14595	COG0431	NADPH-dependent FMN reductase
D0Z02_RS14640	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z02_RS14645	COG0179	Fumarylacetoacetate (FAA) hydrolase
D0Z02_RS14685	COG2944	sequence-specific DNA binding
D0Z02_RS14695	COG2197	response regulator
D0Z02_RS14720	COG3119	arylsulfatase activity
D0Z02_RS14755	COG0714	Associated with various cellular activities
D0Z02_RS14775	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z02_RS14780	COG0861	Integral membrane protein TerC family
D0Z02_RS14825	COG0300	oxidoreductase activity
D0Z02_RS14850	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D0Z02_RS14865	COG0438	transferase activity, transferring glycosyl groups
D0Z02_RS14885	COG0463	Glycosyl transferase, family 2
D0Z02_RS14905	COG0783	Belongs to the Dps family
D0Z02_RS14920	COG0583	DNA-binding transcription factor activity
D0Z02_RS14925	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D0Z02_RS14940	COG0656	L-ascorbic acid biosynthetic process
D0Z02_RS14950	COG0583	DNA-binding transcription factor activity
D0Z02_RS14960	COG1840	ABC-type Fe3 transport system, periplasmic component
D0Z02_RS14965	COG1178	ABC-type Fe3 transport system permease component
D0Z02_RS14970	COG3842	ATPase activity
D0Z02_RS14980	COG1741	Belongs to the pirin family
D0Z02_RS14985	COG1741	Belongs to the pirin family
D0Z02_RS14990	COG0583	DNA-binding transcription factor activity
D0Z02_RS14995	COG2204	response regulator
D0Z02_RS15005	COG0174	glutamine synthetase
D0Z02_RS15020	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D0Z02_RS15025	COG2199	diguanylate cyclase activity
D0Z02_RS15025	COG2200	EAL domain
D0Z02_RS15030	COG0840	transmembrane signaling receptor activity
D0Z02_RS15045	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D0Z02_RS15050	COG1561	YicC-like family, N-terminal region
D0Z02_RS15070	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D0Z02_RS15075	COG0791	NLP P60 protein
D0Z02_RS15080	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z02_RS15085	COG2863	cytochrome
D0Z02_RS15095	COG0194	GDP metabolic process
D0Z02_RS15100	COG1758	RNA polymerase activity
D0Z02_RS15105	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D0Z02_RS15110	COG1126	abc transporter atp-binding protein
D0Z02_RS15115	COG0765	amino acid transport
D0Z02_RS15120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0Z02_RS15135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D0Z02_RS15140	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
D0Z02_RS15145	COG3539	Fimbrial protein
D0Z02_RS15150	COG2850	peptidyl-arginine hydroxylation
D0Z02_RS15155	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D0Z02_RS15210	COG0009	L-threonylcarbamoyladenylate synthase
D0Z02_RS15215	COG2321	neutral zinc metallopeptidase
D0Z02_RS15235	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D0Z02_RS15240	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D0Z02_RS15245	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D0Z02_RS15255	COG1074	ATP-dependent DNA helicase activity
D0Z02_RS15265	COG2814	Major facilitator Superfamily
D0Z02_RS15275	COG1686	Belongs to the peptidase S11 family
D0Z02_RS15290	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D0Z02_RS15300	COG4974	Belongs to the 'phage' integrase family
D0Z02_RS15305	COG0583	DNA-binding transcription factor activity
D0Z02_RS15310	COG0028	Belongs to the TPP enzyme family
D0Z02_RS15325	COG0028	Belongs to the TPP enzyme family
D0Z02_RS15330	COG1126	abc transporter atp-binding protein
D0Z02_RS15335	COG0765	amino acid transport
D0Z02_RS15355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0Z02_RS15360	COG0009	L-threonylcarbamoyladenylate synthase
D0Z02_RS15370	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D0Z02_RS15375	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D0Z02_RS15385	COG2944	sequence-specific DNA binding
D0Z02_RS15395	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D0Z02_RS15450	COG1126	abc transporter atp-binding protein
D0Z02_RS15455	COG0765	amino acid transport
D0Z02_RS15460	COG0765	amino acid transport
D0Z02_RS15465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0Z02_RS15475	COG2423	ornithine cyclodeaminase activity
D0Z02_RS15490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D0Z02_RS15495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0Z02_RS15510	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D0Z02_RS15515	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D0Z02_RS15520	COG2197	response regulator
D0Z02_RS15565	COG3022	response to hydroperoxide
D0Z02_RS15580	COG0135	phosphoribosylanthranilate isomerase activity
D0Z02_RS15600	COG0101	tRNA pseudouridine synthase activity
D0Z02_RS15610	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D0Z02_RS15615	COG0473	3-isopropylmalate dehydrogenase activity
D0Z02_RS15620	COG0066	3-isopropylmalate dehydratase activity
D0Z02_RS15625	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D0Z02_RS15635	COG1122	ATPase activity
D0Z02_RS15670	COG0243	molybdopterin cofactor binding
D0Z02_RS15670	COG3383	formate dehydrogenase (NAD+) activity
D0Z02_RS15700	COG0489	protein tyrosine kinase activity
D0Z02_RS15705	COG0746	molybdenum cofactor guanylyltransferase activity
D0Z02_RS15715	COG1763	Mo-molybdopterin cofactor biosynthetic process
D0Z02_RS15725	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D0Z02_RS15730	COG5001	Diguanylate cyclase
D0Z02_RS15750	COG3842	ATPase activity
D0Z02_RS15775	COG0505	Belongs to the CarA family
D0Z02_RS15780	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D0Z02_RS15815	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D0Z02_RS15820	COG1960	acyl-CoA dehydrogenase activity
D0Z02_RS15830	COG2867	negative regulation of translational initiation
D0Z02_RS15840	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D0Z02_RS15845	COG3706	GGDEF domain
D0Z02_RS15850	COG0330	HflC and HflK could
D0Z02_RS15865	COG0519	Catalyzes the synthesis of GMP from XMP
D0Z02_RS15865	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D0Z02_RS15875	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D0Z02_RS15880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0Z02_RS15885	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D0Z02_RS15890	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D0Z02_RS15900	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D0Z02_RS15905	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D0Z02_RS15910	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
D0Z02_RS15915	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0Z02_RS15925	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D0Z02_RS15935	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D0Z02_RS15940	COG0233	cytoplasmic translational termination
D0Z02_RS15945	COG0528	UMP kinase activity
D0Z02_RS15950	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D0Z02_RS15955	COG0052	Belongs to the universal ribosomal protein uS2 family
D0Z02_RS15960	COG0024	Methionine aminopeptidase
D0Z02_RS15965	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D0Z02_RS15995	COG0285	dihydrofolate synthase activity
D0Z02_RS16030	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D0Z02_RS16040	COG1677	Flagellar hook-basal body complex protein FliE
D0Z02_RS16050	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D0Z02_RS16060	COG1157	protein secretion by the type III secretion system
D0Z02_RS16085	COG1580	Controls the rotational direction of flagella during chemotaxis
D0Z02_RS16105	COG1338	Plays a role in the flagellum-specific transport system
D0Z02_RS16125	COG0840	transmembrane signaling receptor activity
D0Z02_RS16150	COG1256	bacterial-type flagellum assembly
D0Z02_RS16160	COG1706	bacterial-type flagellum-dependent cell motility
D0Z02_RS16165	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D0Z02_RS16180	COG1749	Flagellar hook protein flgE
D0Z02_RS16190	COG1558	bacterial-type flagellum-dependent cell motility
D0Z02_RS16195	COG1815	bacterial-type flagellum-dependent cell motility
D0Z02_RS16235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0Z02_RS16240	COG0765	amino acid transport
D0Z02_RS16245	COG1126	abc transporter atp-binding protein
D0Z02_RS16260	COG4948	Mandelate Racemase Muconate Lactonizing
D0Z02_RS16265	COG3181	Tripartite tricarboxylate transporter family receptor
D0Z02_RS16275	COG0066	3-isopropylmalate dehydratase activity
D0Z02_RS16290	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0Z02_RS16300	COG3181	Tripartite tricarboxylate transporter family receptor
D0Z02_RS16310	COG1802	Transcriptional regulator
D0Z02_RS16325	COG0583	DNA-binding transcription factor activity
D0Z02_RS16345	COG1695	Transcriptional regulator
D0Z02_RS16355	COG3568	Endonuclease Exonuclease Phosphatase
D0Z02_RS16410	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D0Z02_RS16420	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D0Z02_RS16440	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
D0Z02_RS16470	COG0667	Aldo Keto reductase
D0Z02_RS16485	COG2259	Doxx family
D0Z02_RS16520	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0Z02_RS16540	COG0386	Belongs to the glutathione peroxidase family
D0Z02_RS16545	COG0625	glutathione transferase activity
D0Z02_RS16560	COG0095	Lipoate-protein ligase
D0Z02_RS16575	COG0688	phosphatidylethanolamine metabolic process
D0Z02_RS16585	COG1464	Belongs to the NlpA lipoprotein family
D0Z02_RS16600	COG2363	Small membrane protein
D0Z02_RS16625	COG3842	ATPase activity
D0Z02_RS16630	COG0395	ABC-type sugar transport system, permease component
D0Z02_RS16635	COG1175	transmembrane transport
D0Z02_RS16640	COG1653	transport
D0Z02_RS16650	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D0Z02_RS16665	COG0559	Belongs to the binding-protein-dependent transport system permease family
D0Z02_RS16685	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D0Z02_RS16710	COG2311	Membrane
D0Z02_RS16735	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D0Z02_RS16745	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D0Z02_RS16750	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D0Z02_RS16755	COG1760	l-serine dehydratase
D0Z02_RS16760	COG1283	sodium-dependent phosphate transmembrane transporter activity
D0Z02_RS16765	COG0412	Dienelactone hydrolase
D0Z02_RS16780	COG1611	Belongs to the LOG family
D0Z02_RS16800	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D0Z02_RS16805	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D0Z02_RS16810	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D0Z02_RS16815	COG2251	uridine kinase activity
D0Z02_RS16815	COG0195	Participates in both transcription termination and antitermination
D0Z02_RS16820	COG0779	Required for maturation of 30S ribosomal subunits
D0Z02_RS16830	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D0Z02_RS16840	COG0583	DNA-binding transcription factor activity
D0Z02_RS16870	COG0625	glutathione transferase activity
D0Z02_RS16875	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D0Z02_RS16880	COG1047	Peptidyl-prolyl cis-trans
D0Z02_RS16885	COG2003	Belongs to the UPF0758 family
D0Z02_RS16890	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D0Z02_RS16895	COG3483	tryptophan 2,3-dioxygenase activity
D0Z02_RS16900	COG0254	rRNA binding
D0Z02_RS16910	COG0534	Mate efflux family protein
D0Z02_RS16930	COG2304	oxidoreductase activity
D0Z02_RS16950	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z02_RS16955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D0Z02_RS16960	COG1562	ergosterol biosynthetic process
D0Z02_RS16965	COG1562	ergosterol biosynthetic process
D0Z02_RS16975	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D0Z02_RS16985	COG0842	Transport permease protein
D0Z02_RS16990	COG1131	(ABC) transporter
D0Z02_RS17025	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
D0Z02_RS17040	COG5564	TIM-barrel signal transduction protein
D0Z02_RS17045	COG5441	Belongs to the UPF0261 family
D0Z02_RS17055	COG3468	outer membrane autotransporter barrel domain protein
D0Z02_RS17075	COG0542	response to heat
D0Z02_RS17080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0Z02_RS17095	COG0494	nUDIX hydrolase
D0Z02_RS17100	COG3530	Putative quorum-sensing-regulated virulence factor
D0Z02_RS17115	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D0Z02_RS17150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0Z02_RS17155	COG0765	amino acid transport
D0Z02_RS17160	COG0765	amino acid transport
D0Z02_RS17190	COG2988	succinylglutamate desuccinylase activity
D0Z02_RS17215	COG3181	Tripartite tricarboxylate transporter family receptor
D0Z02_RS17220	COG2084	Dehydrogenase
D0Z02_RS17235	COG1619	proteins homologs of microcin C7 resistance protein MccF
D0Z02_RS17250	COG2814	Major facilitator Superfamily
D0Z02_RS17260	COG0583	DNA-binding transcription factor activity
D0Z02_RS17300	COG0672	)-iron permease
D0Z02_RS17315	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
D0Z02_RS17320	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z02_RS17325	COG3243	poly(R)-hydroxyalkanoic acid synthase
D0Z02_RS17335	COG0564	pseudouridine synthase activity
D0Z02_RS17345	COG1199	ATP-dependent helicase activity
D0Z02_RS17355	COG0180	Tryptophanyl-tRNA synthetase
D0Z02_RS17380	COG3181	Tripartite tricarboxylate transporter family receptor
D0Z02_RS17390	COG0583	DNA-binding transcription factor activity
D0Z02_RS17395	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z02_RS17400	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D0Z02_RS17405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0Z02_RS17410	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0Z02_RS17415	COG0567	Dehydrogenase, E1 component
D0Z02_RS17425	COG1522	sequence-specific DNA binding
D0Z02_RS17435	COG0281	malic enzyme
D0Z02_RS17435	COG0280	phosphate acetyltransferase
D0Z02_RS17440	COG3539	Fimbrial protein
D0Z02_RS17460	COG0613	PHP domain protein
D0Z02_RS17495	COG0084	hydrolase, TatD family'
D0Z02_RS17500	COG1136	(ABC) transporter
D0Z02_RS17525	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z02_RS17545	COG1022	Amp-dependent synthetase and ligase
D0Z02_RS17580	COG2205	protein histidine kinase activity
D0Z02_RS17585	COG0745	RESPONSE REGULATOR receiver
D0Z02_RS17590	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D0Z02_RS17600	COG1295	ribonuclease BN
D0Z02_RS17615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D0Z02_RS17645	COG1534	Rna-binding protein
D0Z02_RS17650	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D0Z02_RS17655	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D0Z02_RS17675	COG0248	Ppx GppA phosphatase
D0Z02_RS17700	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D0Z02_RS17715	COG2732	(Barnase) inhibitor
D0Z02_RS17735	COG0436	Aminotransferase
D0Z02_RS17745	COG0741	lytic transglycosylase activity
D0Z02_RS17750	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D0Z02_RS17790	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D0Z02_RS17795	COG2027	D-alanyl-D-alanine carboxypeptidase
D0Z02_RS17800	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D0Z02_RS17805	COG0343	queuine tRNA-ribosyltransferase activity
D0Z02_RS17810	COG1862	Preprotein translocase
D0Z02_RS17815	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0Z02_RS17820	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0Z02_RS17835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D0Z02_RS17840	COG1702	phosphate starvation-inducible protein PhoH
D0Z02_RS17845	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D0Z02_RS17850	COG4535	Mg2 and Co2 transporter CorC
D0Z02_RS17860	COG0667	Aldo Keto reductase
D0Z02_RS17885	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
D0Z02_RS17890	COG0745	RESPONSE REGULATOR receiver
D0Z02_RS17895	COG2201	protein-glutamate methylesterase activity
D0Z02_RS17905	COG0840	transmembrane signaling receptor activity
D0Z02_RS17920	COG0745	RESPONSE REGULATOR receiver
D0Z02_RS17965	COG0739	heme binding
D0Z02_RS17975	COG0521	Mo-molybdopterin cofactor biosynthetic process
D0Z02_RS17985	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D0Z02_RS18015	COG0625	glutathione transferase activity
D0Z02_RS18030	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D0Z02_RS18035	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D0Z02_RS18040	COG0126	phosphoglycerate kinase activity
D0Z02_RS18045	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D0Z02_RS18050	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D0Z02_RS18055	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D0Z02_RS18065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0Z02_RS18070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0Z02_RS18075	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0Z02_RS18080	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D0Z02_RS18090	COG4566	intracellular signal transduction
D0Z02_RS18095	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D0Z02_RS18105	COG1999	signal sequence binding
D0Z02_RS18135	COG1187	pseudouridine synthase activity
D0Z02_RS18140	COG3161	chorismate lyase activity
D0Z02_RS18155	COG0667	Aldo Keto reductase
D0Z02_RS18170	COG0335	large ribosomal subunit rRNA binding
D0Z02_RS18205	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D0Z02_RS18230	COG1960	acyl-CoA dehydrogenase activity
D0Z02_RS18265	COG1596	polysaccharide export
D0Z02_RS18265	COG1555	photosystem II stabilization
D0Z02_RS18270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D0Z02_RS18275	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D0Z02_RS18280	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D0Z02_RS18300	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D0Z02_RS18305	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D0Z02_RS18310	COG0287	Prephenate dehydrogenase
D0Z02_RS18320	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D0Z02_RS18335	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D0Z02_RS18345	COG2814	Major facilitator Superfamily
D0Z02_RS18375	COG0583	DNA-binding transcription factor activity
D0Z02_RS18415	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D0Z02_RS18430	COG0667	Aldo Keto reductase
D0Z02_RS18440	COG5265	(ABC) transporter
D0Z02_RS18490	COG0439	Biotin carboxylase
D0Z02_RS18495	COG2188	Transcriptional regulator
D0Z02_RS18550	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
D0Z02_RS18570	COG0500	methyltransferase
D0Z02_RS18575	COG5265	(ABC) transporter
D0Z02_RS18590	COG0028	Belongs to the TPP enzyme family
D0Z02_RS18595	COG0440	acetolactate synthase activity
D0Z02_RS18600	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D0Z02_RS18605	COG1183	phosphatidylcholine synthase activity
D0Z02_RS18620	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D0Z02_RS18625	COG1185	polyribonucleotide nucleotidyltransferase activity
D0Z02_RS18640	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D0Z02_RS18675	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0Z02_RS18685	COG3799	methylaspartate ammonia-lyase activity
D0Z02_RS18720	COG0583	DNA-binding transcription factor activity
D0Z02_RS18725	COG0626	cystathionine gamma-synthase activity
D0Z02_RS18750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0Z02_RS18770	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
D0Z02_RS18790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0Z02_RS18795	COG1733	regulation of RNA biosynthetic process
D0Z02_RS18810	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0Z02_RS18815	COG0583	DNA-binding transcription factor activity
D0Z02_RS18820	COG1597	lipid kinase activity
D0Z02_RS18830	COG0671	phosphoesterase, PA-phosphatase related
D0Z02_RS18860	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D0Z02_RS18865	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0Z02_RS18870	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0Z02_RS18875	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0Z02_RS18880	COG0649	NAD binding
D0Z02_RS18885	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
D0Z02_RS18895	COG1034	ATP synthesis coupled electron transport
D0Z02_RS18900	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D0Z02_RS18905	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0Z02_RS18915	COG0713	ATP synthesis coupled electron transport
D0Z02_RS18930	COG1007	ATP synthesis coupled electron transport
D0Z02_RS18945	COG4774	siderophore transport
D0Z02_RS18965	COG3181	Tripartite tricarboxylate transporter family receptor
D0Z02_RS18975	COG0560	Phosphoserine phosphatase
D0Z02_RS18980	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D0Z02_RS18985	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D0Z02_RS18990	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D0Z02_RS19015	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D0Z02_RS19020	COG0308	aminopeptidase N
D0Z02_RS19040	COG0028	Belongs to the TPP enzyme family
D0Z02_RS19060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0Z02_RS19070	COG0318	PFAM AMP-dependent synthetase and ligase
D0Z02_RS19080	COG1802	Transcriptional regulator
D0Z02_RS19090	COG1802	Transcriptional regulator
D0Z02_RS19100	COG1028	Short-chain dehydrogenase reductase Sdr
D0Z02_RS19125	COG0765	amino acid transport
D0Z02_RS19145	COG1538	Outer membrane efflux protein
D0Z02_RS19150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0Z02_RS19155	COG2274	protein secretion by the type I secretion system
D0Z02_RS19170	COG2994	toxin metabolic process
D0Z02_RS19205	COG0583	DNA-binding transcription factor activity
D0Z02_RS19215	COG0142	geranyltranstransferase activity
D0Z02_RS19225	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D0Z02_RS19230	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D0Z02_RS19235	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D0Z02_RS19240	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D0Z02_RS19285	COG3712	iron ion homeostasis
D0Z02_RS19290	COG4774	siderophore transport
D0Z02_RS19295	COG2353	YceI-like domain
D0Z02_RS19310	COG0019	diaminopimelate decarboxylase activity
D0Z02_RS19330	COG0747	negative chemotaxis
D0Z02_RS19335	COG0601	transmembrane transport
D0Z02_RS19350	COG0154	amidase activity
D0Z02_RS19355	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D0Z02_RS19380	COG2154	pterin-4-alpha-carbinolamine dehydratase
D0Z02_RS19390	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D0Z02_RS19400	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D0Z02_RS19410	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D0Z02_RS19415	COG1929	Belongs to the glycerate kinase type-1 family
D0Z02_RS19420	COG0469	pyruvate kinase activity
D0Z02_RS19425	COG0700	Nucleoside recognition
D0Z02_RS19465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0Z02_RS19480	COG0823	Involved in the tonB-independent uptake of proteins
D0Z02_RS19490	COG0848	biopolymer transport protein
D0Z02_RS19495	COG0811	peptide transport
D0Z02_RS19500	COG0824	Thioesterase
D0Z02_RS19510	COG0494	nUDIX hydrolase
D0Z02_RS19525	COG2135	peptidase activity
D0Z02_RS19740	COG1464	Belongs to the NlpA lipoprotein family
D0Z02_RS19770	COG4211	Belongs to the binding-protein-dependent transport system permease family
D0Z02_RS19780	COG0154	amidase activity
D0Z02_RS19785	COG0288	reversible hydration of carbon dioxide
D0Z02_RS19800	COG0514	ATP-dependent DNA helicase (RecQ)
D0Z02_RS19805	COG2255	four-way junction helicase activity
D0Z02_RS19820	COG0632	four-way junction helicase activity
D0Z02_RS19825	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D0Z02_RS19855	COG0006	proline dipeptidase activity
D0Z02_RS19880	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D0Z02_RS19895	COG4783	chaperone-mediated protein folding
D0Z02_RS19900	COG0429	hydrolase of the alpha beta-hydrolase fold
D0Z02_RS19930	COG0513	Belongs to the DEAD box helicase family
D0Z02_RS19950	COG1546	Belongs to the CinA family
D0Z02_RS19950	COG1058	Belongs to the CinA family
D0Z02_RS19955	COG1414	Transcriptional regulator
D0Z02_RS19980	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D0Z02_RS19995	COG0583	DNA-binding transcription factor activity