locus-tag	class	description
RD03_RS00005	COG0445	tRNA wobble uridine modification
RD03_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
RD03_RS00015	COG1192	Involved in chromosome partitioning
RD03_RS00025	COG1475	DNA binding
RD03_RS00030	COG0252	asparaginase activity
RD03_RS00055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RD03_RS00065	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RD03_RS00075	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RD03_RS00080	COG0081	regulation of translation
RD03_RS00085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RD03_RS00090	COG0222	ribosome binding
RD03_RS00095	COG0085	RNA polymerase activity
RD03_RS00100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RD03_RS00140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD03_RS00165	COG1024	Enoyl-CoA hydratase
RD03_RS00185	COG0752	glycyl-tRNA synthetase alpha subunit
RD03_RS00190	COG0751	glycine-tRNA ligase activity
RD03_RS00195	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RD03_RS00200	COG0204	Acyl-transferase
RD03_RS00215	COG0242	peptide deformylase activity
RD03_RS00250	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RD03_RS00255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RD03_RS00260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RD03_RS00260	COG2813	Specifically methylates the guanine in position
RD03_RS00270	COG2223	nitrite transmembrane transporter activity
RD03_RS00280	COG1794	racemase activity, acting on amino acids and derivatives
RD03_RS00285	COG1126	abc transporter atp-binding protein
RD03_RS00290	COG0765	amino acid transport
RD03_RS00295	COG0765	amino acid transport
RD03_RS00300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD03_RS00360	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD03_RS00390	COG0326	Molecular chaperone. Has ATPase activity
RD03_RS00395	COG0625	glutathione transferase activity
RD03_RS00410	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RD03_RS00415	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RD03_RS00445	COG0438	transferase activity, transferring glycosyl groups
RD03_RS00450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RD03_RS00455	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RD03_RS00485	COG0859	PFAM glycosyl transferase family 9
RD03_RS00500	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
RD03_RS00510	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RD03_RS00515	COG1127	ABC transporter
RD03_RS00540	COG1686	Belongs to the peptidase S11 family
RD03_RS00550	COG2921	Belongs to the UPF0250 family
RD03_RS00555	COG0321	lipoyl(octanoyl) transferase activity
RD03_RS00560	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RD03_RS00595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RD03_RS00605	COG0018	arginyl-trna synthetase
RD03_RS00625	COG0395	ABC-type sugar transport system, permease component
RD03_RS00630	COG1175	transmembrane transport
RD03_RS00635	COG1653	transport
RD03_RS00640	COG3842	ATPase activity
RD03_RS00645	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RD03_RS00655	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RD03_RS00675	COG1609	Transcriptional regulator
RD03_RS00685	COG0154	amidase activity
RD03_RS00690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RD03_RS00700	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RD03_RS00710	COG0583	DNA-binding transcription factor activity
RD03_RS00725	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RD03_RS00730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RD03_RS00745	COG1802	Transcriptional regulator
RD03_RS00760	COG1024	Enoyl-CoA hydratase
RD03_RS00775	COG3181	Tripartite tricarboxylate transporter family receptor
RD03_RS00790	COG1984	allophanate hydrolase subunit 2
RD03_RS00795	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RD03_RS00805	COG0583	DNA-binding transcription factor activity
RD03_RS00810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RD03_RS00820	COG5002	protein histidine kinase activity
RD03_RS00830	COG5002	protein histidine kinase activity
RD03_RS00835	COG0745	RESPONSE REGULATOR receiver
RD03_RS00840	COG2226	methyltransferase
RD03_RS00855	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RD03_RS00875	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
RD03_RS00885	COG0513	Belongs to the DEAD box helicase family
RD03_RS00890	COG1280	lysine exporter protein (LysE YggA)
RD03_RS00895	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
RD03_RS00930	COG1054	Belongs to the UPF0176 family
RD03_RS00935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RD03_RS00935	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RD03_RS00945	COG0489	protein tyrosine kinase activity
RD03_RS00960	COG0717	Belongs to the dCTP deaminase family
RD03_RS00990	COG2081	HI0933 family
RD03_RS01000	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RD03_RS01010	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RD03_RS01015	COG0509	glycine decarboxylation via glycine cleavage system
RD03_RS01020	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RD03_RS01020	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RD03_RS01060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RD03_RS01075	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RD03_RS01085	COG1414	Transcriptional regulator
RD03_RS01090	COG1028	Short-chain dehydrogenase reductase Sdr
RD03_RS01095	COG2031	fatty acid transporter
RD03_RS01100	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD03_RS01110	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
RD03_RS01115	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
RD03_RS01125	COG4257	antibiotic catabolic process
RD03_RS01145	COG1012	belongs to the aldehyde dehydrogenase family
RD03_RS01150	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
RD03_RS01155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RD03_RS01180	COG1028	Short-chain dehydrogenase reductase Sdr
RD03_RS01190	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RD03_RS01200	COG2188	Transcriptional regulator
RD03_RS01205	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD03_RS01230	COG0617	tRNA 3'-terminal CCA addition
RD03_RS01245	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RD03_RS01250	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RD03_RS01255	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RD03_RS01260	COG0586	Pfam SNARE associated Golgi protein
RD03_RS01265	COG0860	N-Acetylmuramoyl-L-alanine amidase
RD03_RS01270	COG0802	atpase or kinase
RD03_RS01275	COG0114	fumarate hydratase activity
RD03_RS01285	COG3181	Tripartite tricarboxylate transporter family receptor
RD03_RS01295	COG0405	Gamma-glutamyltransferase
RD03_RS01300	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD03_RS01310	COG1960	acyl-CoA dehydrogenase activity
RD03_RS01335	COG1294	oxidase, subunit
RD03_RS01345	COG4988	ABC transporter
RD03_RS01350	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
RD03_RS01355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RD03_RS01370	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RD03_RS01395	COG2969	positive regulation of protein catabolic process
RD03_RS01400	COG0625	glutathione transferase activity
RD03_RS01405	COG2857	Cytochrome c1
RD03_RS01410	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RD03_RS01415	COG0723	plastoquinol--plastocyanin reductase activity
RD03_RS01420	COG1970	mechanosensitive ion channel activity
RD03_RS01425	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RD03_RS01440	COG2808	Putative FMN-binding domain
RD03_RS01445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RD03_RS01450	COG0747	negative chemotaxis
RD03_RS01455	COG0657	acetylesterase activity
RD03_RS01465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RD03_RS01470	COG2207	Transcriptional regulator
RD03_RS01475	COG0129	dihydroxy-acid dehydratase activity
RD03_RS01480	COG2814	Major facilitator Superfamily
RD03_RS01485	COG0583	DNA-binding transcription factor activity
RD03_RS01495	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
RD03_RS01565	COG1024	Enoyl-CoA hydratase
RD03_RS01570	COG1960	acyl-CoA dehydrogenase activity
RD03_RS01595	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RD03_RS01600	COG0352	thiamine-phosphate diphosphorylase activity
RD03_RS01615	COG1678	Uncharacterized ACR, COG1678
RD03_RS01620	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RD03_RS01625	COG0540	Belongs to the ATCase OTCase family
RD03_RS01640	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RD03_RS01650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RD03_RS01685	COG1234	tRNA 3'-trailer cleavage
RD03_RS01730	COG1683	Conserved Protein
RD03_RS01735	COG1120	ATPase activity
RD03_RS01740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RD03_RS01745	COG4558	Periplasmic binding protein
RD03_RS01750	COG3720	iron ion transport
RD03_RS01760	COG3712	iron ion homeostasis
RD03_RS01765	COG1595	DNA-templated transcription, initiation
RD03_RS01800	COG1802	Transcriptional regulator
RD03_RS01810	COG3069	C4-dicarboxylate transmembrane transporter activity
RD03_RS01820	COG1012	belongs to the aldehyde dehydrogenase family
RD03_RS01855	COG2860	membrane
RD03_RS01860	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RD03_RS01865	COG0708	Exodeoxyribonuclease III
RD03_RS01870	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RD03_RS01875	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RD03_RS01880	COG0154	amidase activity
RD03_RS01885	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RD03_RS01890	COG1077	Cell shape determining protein MreB Mrl
RD03_RS01895	COG1792	Involved in formation and maintenance of cell shape
RD03_RS01905	COG0768	penicillin binding
RD03_RS01910	COG0772	Belongs to the SEDS family
RD03_RS01915	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RD03_RS01920	COG0471	metal ion transport
RD03_RS01925	COG1309	transcriptional regulator
RD03_RS01935	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RD03_RS01950	COG2823	Periplasmic or secreted lipoprotein
RD03_RS01955	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
RD03_RS01970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RD03_RS01990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD03_RS02000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD03_RS02025	COG0492	ferredoxin-NADP+ reductase activity
RD03_RS02035	COG3181	Tripartite tricarboxylate transporter family receptor
RD03_RS02040	COG1024	Enoyl-CoA hydratase
RD03_RS02040	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD03_RS02045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD03_RS02050	COG0028	Belongs to the TPP enzyme family
RD03_RS02075	COG3181	Tripartite tricarboxylate transporter family receptor
RD03_RS02090	COG0697	spore germination
RD03_RS02115	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RD03_RS02120	COG0463	Glycosyl transferase, family 2
RD03_RS02135	COG0786	glutamate:sodium symporter activity
RD03_RS02145	COG2031	fatty acid transporter
RD03_RS02160	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RD03_RS02165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RD03_RS02175	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RD03_RS02190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RD03_RS02200	COG1285	pathogenesis
RD03_RS02205	COG1253	flavin adenine dinucleotide binding
RD03_RS02210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD03_RS02215	COG1024	Enoyl-CoA hydratase
RD03_RS02220	COG3181	Tripartite tricarboxylate transporter family receptor
RD03_RS02225	COG0583	DNA-binding transcription factor activity
RD03_RS02230	COG1960	acyl-CoA dehydrogenase activity
RD03_RS02240	COG0183	Belongs to the thiolase family
RD03_RS02260	COG0583	DNA-binding transcription factor activity
RD03_RS02265	COG1278	Cold shock
RD03_RS02275	COG1802	Transcriptional regulator
RD03_RS02280	COG1012	belongs to the aldehyde dehydrogenase family
RD03_RS02285	COG2031	fatty acid transporter
RD03_RS02290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RD03_RS02290	COG1017	nitric oxide dioxygenase activity
RD03_RS02295	COG0251	oxidation-reduction process
RD03_RS02320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD03_RS02330	COG0583	DNA-binding transcription factor activity
RD03_RS02335	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD03_RS02345	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
RD03_RS02350	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RD03_RS02355	COG0546	phosphoglycolate phosphatase activity
RD03_RS02365	COG1530	ribonuclease E activity
RD03_RS02380	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
RD03_RS02385	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RD03_RS02390	COG0159	tryptophan synthase activity
RD03_RS02395	COG0133	tryptophan synthase activity
RD03_RS02405	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RD03_RS02410	COG3228	Belongs to the MtfA family
RD03_RS02420	COG0251	oxidation-reduction process
RD03_RS02425	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
RD03_RS02430	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RD03_RS02445	COG2878	Part of a membrane complex involved in electron transport
RD03_RS02450	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RD03_RS02485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RD03_RS02505	COG1268	BioY protein
RD03_RS02510	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
RD03_RS02515	COG1122	ATPase activity
RD03_RS02520	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RD03_RS02535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RD03_RS02540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RD03_RS02550	COG1196	nuclear chromosome segregation
RD03_RS02555	COG0477	Major facilitator Superfamily
RD03_RS02560	COG1573	uracil-dna glycosylase
RD03_RS02565	COG1214	PFAM Peptidase M22, glycoprotease
RD03_RS02585	COG0450	alkyl hydroperoxide reductase
RD03_RS02590	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RD03_RS02600	COG2223	nitrite transmembrane transporter activity
RD03_RS02610	COG2186	Transcriptional regulator
RD03_RS02630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RD03_RS02640	COG0583	DNA-binding transcription factor activity
RD03_RS02650	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RD03_RS02655	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RD03_RS02660	COG0137	argininosuccinate synthase activity
RD03_RS02665	COG3158	transport of potassium into the cell
RD03_RS02670	COG0642	Histidine kinase
RD03_RS02700	COG0776	regulation of translation
RD03_RS02705	COG3128	pkhd-type hydroxylase
RD03_RS02715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RD03_RS02720	COG0557	exoribonuclease II activity
RD03_RS02745	COG0679	Auxin Efflux Carrier
RD03_RS02750	COG2391	methyltransferase activity
RD03_RS02755	COG0069	glutamate synthase activity
RD03_RS02765	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RD03_RS02775	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
RD03_RS02780	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RD03_RS02815	COG3706	GGDEF domain
RD03_RS02835	COG1053	succinate dehydrogenase
RD03_RS02840	COG0583	DNA-binding transcription factor activity
RD03_RS02850	COG1053	succinate dehydrogenase
RD03_RS02870	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RD03_RS02875	COG0459	protein refolding
RD03_RS02880	COG3468	outer membrane autotransporter barrel domain protein
RD03_RS02895	COG1252	NADH dehydrogenase
RD03_RS02900	COG0284	orotidine-5'-phosphate decarboxylase activity
RD03_RS02905	COG1058	Belongs to the CinA family
RD03_RS02905	COG1546	Belongs to the CinA family
RD03_RS02910	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RD03_RS02920	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RD03_RS02925	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RD03_RS02960	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RD03_RS02965	COG3639	organic phosphonate transmembrane transporter activity
RD03_RS02970	COG3639	organic phosphonate transmembrane transporter activity
RD03_RS02990	COG0742	ribosomal rna small subunit methyltransferase
RD03_RS02995	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RD03_RS03000	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RD03_RS03005	COG3135	benzoate transporter
RD03_RS03020	COG0640	Transcriptional regulator
RD03_RS03050	COG4172	Belongs to the ABC transporter superfamily
RD03_RS03055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD03_RS03060	COG0601	transmembrane transport
RD03_RS03070	COG0280	phosphate acetyltransferase
RD03_RS03070	COG0281	malic enzyme
RD03_RS03130	COG0583	DNA-binding transcription factor activity
RD03_RS03140	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
RD03_RS03145	COG0167	dihydroorotate dehydrogenase activity
RD03_RS03165	COG1414	Transcriptional regulator
RD03_RS03170	COG1546	Belongs to the CinA family
RD03_RS03170	COG1058	Belongs to the CinA family
RD03_RS03190	COG0513	Belongs to the DEAD box helicase family
RD03_RS03220	COG0429	hydrolase of the alpha beta-hydrolase fold
RD03_RS03225	COG4783	chaperone-mediated protein folding
RD03_RS03240	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RD03_RS03265	COG0006	proline dipeptidase activity
RD03_RS03275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RD03_RS03295	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RD03_RS03300	COG0632	four-way junction helicase activity
RD03_RS03315	COG2255	four-way junction helicase activity
RD03_RS03320	COG0514	ATP-dependent DNA helicase (RecQ)
RD03_RS03335	COG0288	reversible hydration of carbon dioxide
RD03_RS03340	COG0154	amidase activity
RD03_RS03350	COG4211	Belongs to the binding-protein-dependent transport system permease family
RD03_RS03380	COG1464	Belongs to the NlpA lipoprotein family
RD03_RS03520	COG1196	nuclear chromosome segregation
RD03_RS03585	COG2135	peptidase activity
RD03_RS03600	COG0494	nUDIX hydrolase
RD03_RS03605	COG0442	prolyl-tRNA aminoacylation
RD03_RS03610	COG0824	Thioesterase
RD03_RS03615	COG0811	peptide transport
RD03_RS03620	COG0848	biopolymer transport protein
RD03_RS03630	COG0823	Involved in the tonB-independent uptake of proteins
RD03_RS03645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RD03_RS03650	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
RD03_RS03680	COG0700	Nucleoside recognition
RD03_RS03685	COG0469	pyruvate kinase activity
RD03_RS03690	COG1929	Belongs to the glycerate kinase type-1 family
RD03_RS03695	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RD03_RS03700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RD03_RS03705	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RD03_RS03715	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RD03_RS03725	COG2154	pterin-4-alpha-carbinolamine dehydratase
RD03_RS03750	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RD03_RS03755	COG0154	amidase activity
RD03_RS03765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD03_RS03770	COG0601	transmembrane transport
RD03_RS03775	COG0747	negative chemotaxis
RD03_RS03795	COG0019	diaminopimelate decarboxylase activity
RD03_RS03815	COG2353	YceI-like domain
RD03_RS03820	COG4774	siderophore transport
RD03_RS03825	COG3712	iron ion homeostasis
RD03_RS03865	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RD03_RS03870	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RD03_RS03875	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RD03_RS03880	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RD03_RS03890	COG0142	geranyltranstransferase activity
RD03_RS03900	COG0583	DNA-binding transcription factor activity
RD03_RS03910	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
RD03_RS03915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD03_RS03930	COG2994	toxin metabolic process
RD03_RS03940	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
RD03_RS03945	COG2274	protein secretion by the type I secretion system
RD03_RS03950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RD03_RS03955	COG1538	Outer membrane efflux protein
RD03_RS03975	COG0765	amino acid transport
RD03_RS03980	COG1126	abc transporter atp-binding protein
RD03_RS04000	COG1028	Short-chain dehydrogenase reductase Sdr
RD03_RS04010	COG1802	Transcriptional regulator
RD03_RS04020	COG1802	Transcriptional regulator
RD03_RS04030	COG0318	PFAM AMP-dependent synthetase and ligase
RD03_RS04040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD03_RS04060	COG0028	Belongs to the TPP enzyme family
RD03_RS04080	COG0308	aminopeptidase N
RD03_RS04085	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
RD03_RS04095	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RD03_RS04100	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RD03_RS04105	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RD03_RS04110	COG0560	Phosphoserine phosphatase
RD03_RS04115	COG0583	DNA-binding transcription factor activity
RD03_RS04120	COG3181	Tripartite tricarboxylate transporter family receptor
RD03_RS04125	COG0028	Belongs to the TPP enzyme family
RD03_RS04140	COG4774	siderophore transport
RD03_RS04145	COG4774	siderophore transport
RD03_RS04155	COG1007	ATP synthesis coupled electron transport
RD03_RS04170	COG0713	ATP synthesis coupled electron transport
RD03_RS04180	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RD03_RS04185	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
RD03_RS04190	COG1034	ATP synthesis coupled electron transport
RD03_RS04200	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
RD03_RS04205	COG0649	NAD binding
RD03_RS04210	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RD03_RS04215	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RD03_RS04220	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RD03_RS04225	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RD03_RS04250	COG0671	phosphoesterase, PA-phosphatase related
RD03_RS04260	COG1597	lipid kinase activity
RD03_RS04265	COG0583	DNA-binding transcription factor activity
RD03_RS04270	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RD03_RS04280	COG1733	regulation of RNA biosynthetic process
RD03_RS04285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RD03_RS04290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RD03_RS04305	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
RD03_RS04325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD03_RS04345	COG3608	succinylglutamate desuccinylase aspartoacylase
RD03_RS04350	COG0626	cystathionine gamma-synthase activity
RD03_RS04355	COG0583	DNA-binding transcription factor activity
RD03_RS04395	COG3799	methylaspartate ammonia-lyase activity
RD03_RS04405	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RD03_RS04415	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RD03_RS04420	COG0149	triose-phosphate isomerase activity
RD03_RS04440	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RD03_RS04455	COG1185	polyribonucleotide nucleotidyltransferase activity
RD03_RS04460	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RD03_RS04470	COG1183	phosphatidylcholine synthase activity
RD03_RS04475	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RD03_RS04480	COG0440	acetolactate synthase activity
RD03_RS04485	COG0028	Belongs to the TPP enzyme family
RD03_RS04500	COG5265	(ABC) transporter
RD03_RS04505	COG0500	methyltransferase
RD03_RS04520	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
RD03_RS04540	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
RD03_RS04550	COG0511	ligase activity, forming carbon-carbon bonds
RD03_RS04575	COG2188	Transcriptional regulator
RD03_RS04580	COG0439	Biotin carboxylase
RD03_RS04585	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RD03_RS04630	COG5265	(ABC) transporter
RD03_RS04640	COG0667	Aldo Keto reductase
RD03_RS04655	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RD03_RS04690	COG0583	DNA-binding transcription factor activity
RD03_RS04715	COG2814	Major facilitator Superfamily
RD03_RS04725	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RD03_RS04740	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RD03_RS04750	COG0287	Prephenate dehydrogenase
RD03_RS04755	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RD03_RS04760	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RD03_RS04780	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
RD03_RS04785	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
RD03_RS04790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RD03_RS04795	COG1596	polysaccharide export
RD03_RS04795	COG1555	photosystem II stabilization
RD03_RS04810	COG2951	lytic endotransglycosylase activity
RD03_RS04815	COG0123	including yeast histone deacetylase and acetoin utilization protein
RD03_RS04830	COG1960	acyl-CoA dehydrogenase activity
RD03_RS04835	COG0450	alkyl hydroperoxide reductase
RD03_RS04850	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
RD03_RS04855	COG4208	sulfate ABC transporter
RD03_RS04860	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RD03_RS04865	COG0175	sulfate reduction
RD03_RS04895	COG0335	large ribosomal subunit rRNA binding
RD03_RS04910	COG0667	Aldo Keto reductase
RD03_RS04920	COG2814	Major facilitator Superfamily
RD03_RS04925	COG3161	chorismate lyase activity
RD03_RS04930	COG1187	pseudouridine synthase activity
RD03_RS04940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RD03_RS04960	COG1999	signal sequence binding
RD03_RS04965	COG0339	signal peptide processing
RD03_RS04970	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RD03_RS04975	COG4566	intracellular signal transduction
RD03_RS04985	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
RD03_RS04990	COG0508	dehydrogenase complex catalyzes the overall conversion of
RD03_RS04995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RD03_RS05000	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RD03_RS05010	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RD03_RS05015	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RD03_RS05020	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RD03_RS05025	COG0126	phosphoglycerate kinase activity
RD03_RS05030	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RD03_RS05035	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RD03_RS05050	COG0625	glutathione transferase activity
RD03_RS05080	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
RD03_RS05090	COG0521	Mo-molybdopterin cofactor biosynthetic process
RD03_RS05100	COG0739	heme binding
RD03_RS05110	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RD03_RS05145	COG0745	RESPONSE REGULATOR receiver
RD03_RS05160	COG0840	transmembrane signaling receptor activity
RD03_RS05170	COG2201	protein-glutamate methylesterase activity
RD03_RS05175	COG0745	RESPONSE REGULATOR receiver
RD03_RS05180	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
RD03_RS05205	COG0667	Aldo Keto reductase
RD03_RS05215	COG4535	Mg2 and Co2 transporter CorC
RD03_RS05220	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RD03_RS05225	COG1702	phosphate starvation-inducible protein PhoH
RD03_RS05230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RD03_RS05245	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RD03_RS05250	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RD03_RS05255	COG1862	Preprotein translocase
RD03_RS05260	COG0343	queuine tRNA-ribosyltransferase activity
RD03_RS05265	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RD03_RS05270	COG2027	D-alanyl-D-alanine carboxypeptidase
RD03_RS05275	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RD03_RS05285	COG3468	outer membrane autotransporter barrel domain protein
RD03_RS05290	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RD03_RS05290	COG1648	precorrin-2 dehydrogenase activity
RD03_RS05315	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
RD03_RS05320	COG0741	lytic transglycosylase activity
RD03_RS05325	COG0436	Aminotransferase
RD03_RS05335	COG0280	phosphate acetyltransferase
RD03_RS05335	COG0281	malic enzyme
RD03_RS05345	COG2732	(Barnase) inhibitor
RD03_RS05365	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RD03_RS05390	COG0248	Ppx GppA phosphatase
RD03_RS05400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RD03_RS05410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RD03_RS05415	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
RD03_RS05420	COG1534	Rna-binding protein
RD03_RS05445	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RD03_RS05460	COG1295	ribonuclease BN
RD03_RS05470	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
RD03_RS05475	COG0745	RESPONSE REGULATOR receiver
RD03_RS05480	COG2205	protein histidine kinase activity
RD03_RS05515	COG1022	Amp-dependent synthetase and ligase
RD03_RS05530	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RD03_RS05535	COG1028	Short-chain dehydrogenase reductase Sdr
RD03_RS05540	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RD03_RS05545	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RD03_RS05560	COG1136	(ABC) transporter
RD03_RS05565	COG0084	hydrolase, TatD family'
RD03_RS05600	COG0613	PHP domain protein
RD03_RS05615	COG3539	Fimbrial protein
RD03_RS05620	COG0280	phosphate acetyltransferase
RD03_RS05620	COG0281	malic enzyme
RD03_RS05630	COG1522	sequence-specific DNA binding
RD03_RS05635	COG1297	OPT oligopeptide transporter protein
RD03_RS05640	COG1297	OPT oligopeptide transporter protein
RD03_RS05645	COG0567	Dehydrogenase, E1 component
RD03_RS05650	COG0508	dehydrogenase complex catalyzes the overall conversion of
RD03_RS05655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RD03_RS05660	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RD03_RS05665	COG1028	Short-chain dehydrogenase reductase Sdr
RD03_RS05670	COG0583	DNA-binding transcription factor activity
RD03_RS05680	COG3181	Tripartite tricarboxylate transporter family receptor
RD03_RS05700	COG0180	Tryptophanyl-tRNA synthetase
RD03_RS05705	COG2183	response to ionizing radiation
RD03_RS05710	COG1199	ATP-dependent helicase activity
RD03_RS05720	COG0564	pseudouridine synthase activity
RD03_RS05730	COG3243	poly(R)-hydroxyalkanoic acid synthase
RD03_RS05735	COG1028	Short-chain dehydrogenase reductase Sdr
RD03_RS05740	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
RD03_RS05755	COG0672	)-iron permease
RD03_RS05795	COG0583	DNA-binding transcription factor activity
RD03_RS05805	COG2814	Major facilitator Superfamily
RD03_RS05820	COG1619	proteins homologs of microcin C7 resistance protein MccF
RD03_RS05835	COG2084	Dehydrogenase
RD03_RS05840	COG3181	Tripartite tricarboxylate transporter family receptor
RD03_RS05865	COG2988	succinylglutamate desuccinylase activity
RD03_RS05895	COG0765	amino acid transport
RD03_RS05900	COG0765	amino acid transport
RD03_RS05905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD03_RS05940	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RD03_RS05945	COG1595	DNA-templated transcription, initiation
RD03_RS05955	COG3530	Putative quorum-sensing-regulated virulence factor
RD03_RS05960	COG0494	nUDIX hydrolase
RD03_RS05975	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RD03_RS05980	COG0542	response to heat
RD03_RS05990	COG3468	outer membrane autotransporter barrel domain protein
RD03_RS05995	COG3468	outer membrane autotransporter barrel domain protein
RD03_RS06005	COG5441	Belongs to the UPF0261 family
RD03_RS06010	COG5564	TIM-barrel signal transduction protein
RD03_RS06025	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
RD03_RS06040	COG1477	protein flavinylation
RD03_RS06060	COG1131	(ABC) transporter
RD03_RS06065	COG0842	Transport permease protein
RD03_RS06075	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RD03_RS06080	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
RD03_RS06080	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
RD03_RS06085	COG1562	ergosterol biosynthetic process
RD03_RS06090	COG1562	ergosterol biosynthetic process
RD03_RS06095	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RD03_RS06100	COG1028	Short-chain dehydrogenase reductase Sdr
RD03_RS06120	COG2304	oxidoreductase activity
RD03_RS06140	COG0534	Mate efflux family protein
RD03_RS06150	COG0254	rRNA binding
RD03_RS06155	COG3483	tryptophan 2,3-dioxygenase activity
RD03_RS06160	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
RD03_RS06165	COG2003	Belongs to the UPF0758 family
RD03_RS06170	COG1047	Peptidyl-prolyl cis-trans
RD03_RS06175	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RD03_RS06180	COG0625	glutathione transferase activity
RD03_RS06200	COG0523	cobalamin synthesis protein
RD03_RS06210	COG0583	DNA-binding transcription factor activity
RD03_RS06220	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RD03_RS06225	COG1187	pseudouridine synthase activity
RD03_RS06230	COG0779	Required for maturation of 30S ribosomal subunits
RD03_RS06235	COG2251	uridine kinase activity
RD03_RS06235	COG0195	Participates in both transcription termination and antitermination
RD03_RS06240	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RD03_RS06245	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RD03_RS06250	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RD03_RS06270	COG1611	Belongs to the LOG family
RD03_RS06285	COG0412	Dienelactone hydrolase
RD03_RS06290	COG1283	sodium-dependent phosphate transmembrane transporter activity
RD03_RS06295	COG1760	l-serine dehydratase
RD03_RS06300	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RD03_RS06305	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RD03_RS06315	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RD03_RS06340	COG2311	Membrane
RD03_RS06350	COG0697	spore germination
RD03_RS06365	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RD03_RS06385	COG0559	Belongs to the binding-protein-dependent transport system permease family
RD03_RS06400	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
RD03_RS06410	COG1653	transport
RD03_RS06415	COG1175	transmembrane transport
RD03_RS06420	COG0395	ABC-type sugar transport system, permease component
RD03_RS06425	COG3842	ATPase activity
RD03_RS06450	COG2363	Small membrane protein
RD03_RS06465	COG1464	Belongs to the NlpA lipoprotein family
RD03_RS06475	COG0688	phosphatidylethanolamine metabolic process
RD03_RS06490	COG0095	Lipoate-protein ligase
RD03_RS06505	COG0625	glutathione transferase activity
RD03_RS06510	COG0386	Belongs to the glutathione peroxidase family
RD03_RS06530	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD03_RS06560	COG2259	Doxx family
RD03_RS06575	COG0667	Aldo Keto reductase
RD03_RS06605	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
RD03_RS06620	COG1640	4-alpha-glucanotransferase
RD03_RS06630	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RD03_RS06640	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RD03_RS06680	COG0392	lysyltransferase activity
RD03_RS06695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RD03_RS06700	COG3568	Endonuclease Exonuclease Phosphatase
RD03_RS06705	COG1695	Transcriptional regulator
RD03_RS06725	COG0583	DNA-binding transcription factor activity
RD03_RS06740	COG1802	Transcriptional regulator
RD03_RS06750	COG3181	Tripartite tricarboxylate transporter family receptor
RD03_RS06760	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD03_RS06775	COG0066	3-isopropylmalate dehydratase activity
RD03_RS06785	COG3181	Tripartite tricarboxylate transporter family receptor
RD03_RS06790	COG4948	Mandelate Racemase Muconate Lactonizing
RD03_RS06805	COG1126	abc transporter atp-binding protein
RD03_RS06810	COG0765	amino acid transport
RD03_RS06815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD03_RS06855	COG1815	bacterial-type flagellum-dependent cell motility
RD03_RS06860	COG1558	bacterial-type flagellum-dependent cell motility
RD03_RS06870	COG1749	Flagellar hook protein flgE
RD03_RS06885	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
RD03_RS06890	COG1706	bacterial-type flagellum-dependent cell motility
RD03_RS06900	COG1256	bacterial-type flagellum assembly
RD03_RS06910	COG0840	transmembrane signaling receptor activity
RD03_RS06915	COG0840	transmembrane signaling receptor activity
RD03_RS06920	COG0840	transmembrane signaling receptor activity
RD03_RS06940	COG1338	Plays a role in the flagellum-specific transport system
RD03_RS06960	COG1580	Controls the rotational direction of flagella during chemotaxis
RD03_RS06985	COG1157	protein secretion by the type III secretion system
RD03_RS06995	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RD03_RS07005	COG1677	Flagellar hook-basal body complex protein FliE
RD03_RS07015	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RD03_RS07050	COG0285	dihydrofolate synthase activity
RD03_RS07080	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
RD03_RS07085	COG0024	Methionine aminopeptidase
RD03_RS07090	COG0052	Belongs to the universal ribosomal protein uS2 family
RD03_RS07095	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RD03_RS07100	COG0528	UMP kinase activity
RD03_RS07105	COG0233	cytoplasmic translational termination
RD03_RS07110	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RD03_RS07120	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RD03_RS07125	COG0750	zinc metalloprotease
RD03_RS07130	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RD03_RS07135	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
RD03_RS07140	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RD03_RS07145	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RD03_RS07155	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RD03_RS07160	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RD03_RS07165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RD03_RS07170	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
RD03_RS07180	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RD03_RS07180	COG0519	Catalyzes the synthesis of GMP from XMP
RD03_RS07195	COG0330	HflC and HflK could
RD03_RS07200	COG3706	GGDEF domain
RD03_RS07205	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RD03_RS07215	COG2867	negative regulation of translational initiation
RD03_RS07225	COG1960	acyl-CoA dehydrogenase activity
RD03_RS07230	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
RD03_RS07260	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RD03_RS07265	COG0505	Belongs to the CarA family
RD03_RS07270	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RD03_RS07280	COG0406	alpha-ribazole phosphatase activity
RD03_RS07290	COG3842	ATPase activity
RD03_RS07310	COG5001	Diguanylate cyclase
RD03_RS07315	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RD03_RS07325	COG1763	Mo-molybdopterin cofactor biosynthetic process
RD03_RS07330	COG0303	'Molybdopterin
RD03_RS07335	COG0746	molybdenum cofactor guanylyltransferase activity
RD03_RS07340	COG0489	protein tyrosine kinase activity
RD03_RS07370	COG0243	molybdopterin cofactor binding
RD03_RS07370	COG3383	formate dehydrogenase (NAD+) activity
RD03_RS07375	COG0437	4 iron, 4 sulfur cluster binding
RD03_RS07405	COG1122	ATPase activity
RD03_RS07415	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RD03_RS07420	COG0066	3-isopropylmalate dehydratase activity
RD03_RS07425	COG0473	3-isopropylmalate dehydrogenase activity
RD03_RS07430	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RD03_RS07440	COG0101	tRNA pseudouridine synthase activity
RD03_RS07445	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD03_RS07460	COG0135	phosphoribosylanthranilate isomerase activity
RD03_RS07475	COG3022	response to hydroperoxide
RD03_RS07505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RD03_RS07515	COG2197	response regulator
RD03_RS07520	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RD03_RS07525	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RD03_RS07530	COG0189	ligase activity
RD03_RS07540	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RD03_RS07545	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RD03_RS07555	COG2423	ornithine cyclodeaminase activity
RD03_RS07565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD03_RS07570	COG0765	amino acid transport
RD03_RS07575	COG0765	amino acid transport
RD03_RS07580	COG1126	abc transporter atp-binding protein
RD03_RS07635	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RD03_RS07645	COG2944	sequence-specific DNA binding
RD03_RS07650	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
RD03_RS07655	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RD03_RS07660	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RD03_RS07665	COG0009	L-threonylcarbamoyladenylate synthase
RD03_RS07670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD03_RS07675	COG1414	Transcriptional regulator
RD03_RS07690	COG0765	amino acid transport
RD03_RS07695	COG1126	abc transporter atp-binding protein
RD03_RS07700	COG0028	Belongs to the TPP enzyme family
RD03_RS07715	COG0028	Belongs to the TPP enzyme family
RD03_RS07720	COG0583	DNA-binding transcription factor activity
RD03_RS07725	COG4974	Belongs to the 'phage' integrase family
RD03_RS07730	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RD03_RS07735	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
RD03_RS07750	COG1686	Belongs to the peptidase S11 family
RD03_RS07760	COG2814	Major facilitator Superfamily
RD03_RS07770	COG1074	ATP-dependent DNA helicase activity
RD03_RS07780	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RD03_RS07785	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RD03_RS07790	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RD03_RS07810	COG2321	neutral zinc metallopeptidase
RD03_RS07815	COG0009	L-threonylcarbamoyladenylate synthase
RD03_RS07855	COG3360	Dodecin
RD03_RS07860	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RD03_RS07865	COG2850	peptidyl-arginine hydroxylation
RD03_RS07870	COG3539	Fimbrial protein
RD03_RS07875	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
RD03_RS07880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RD03_RS07885	COG1994	Peptidase M50
RD03_RS07895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD03_RS07900	COG0765	amino acid transport
RD03_RS07905	COG1126	abc transporter atp-binding protein
RD03_RS07910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RD03_RS07915	COG1758	RNA polymerase activity
RD03_RS07920	COG0194	GDP metabolic process
RD03_RS07925	COG3258	Cytochrome c
RD03_RS07930	COG2863	cytochrome
RD03_RS07935	COG1028	Short-chain dehydrogenase reductase Sdr
RD03_RS07940	COG0791	NLP P60 protein
RD03_RS07945	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RD03_RS07965	COG1561	YicC-like family, N-terminal region
RD03_RS07970	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RD03_RS07985	COG2199	diguanylate cyclase activity
RD03_RS07985	COG2200	EAL domain
RD03_RS07990	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RD03_RS08000	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RD03_RS08005	COG0174	glutamine synthetase
RD03_RS08015	COG2204	response regulator
RD03_RS08020	COG0583	DNA-binding transcription factor activity
RD03_RS08025	COG1741	Belongs to the pirin family
RD03_RS08030	COG1741	Belongs to the pirin family
RD03_RS08040	COG3842	ATPase activity
RD03_RS08045	COG1178	ABC-type Fe3 transport system permease component
RD03_RS08050	COG1840	ABC-type Fe3 transport system, periplasmic component
RD03_RS08060	COG0583	DNA-binding transcription factor activity
RD03_RS08070	COG0656	L-ascorbic acid biosynthetic process
RD03_RS08095	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RD03_RS08100	COG0583	DNA-binding transcription factor activity
RD03_RS08115	COG0783	Belongs to the Dps family
RD03_RS08150	COG0438	transferase activity, transferring glycosyl groups
RD03_RS08165	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
RD03_RS08190	COG0300	oxidoreductase activity
RD03_RS08245	COG0861	Integral membrane protein TerC family
RD03_RS08250	COG1028	Short-chain dehydrogenase reductase Sdr
RD03_RS08270	COG0714	Associated with various cellular activities
RD03_RS08300	COG3119	arylsulfatase activity
RD03_RS08325	COG2197	response regulator
RD03_RS08335	COG2944	sequence-specific DNA binding
RD03_RS08340	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
RD03_RS08345	COG0625	glutathione transferase activity
RD03_RS08375	COG0179	Fumarylacetoacetate (FAA) hydrolase
RD03_RS08380	COG1028	Short-chain dehydrogenase reductase Sdr
RD03_RS08425	COG0431	NADPH-dependent FMN reductase
RD03_RS08455	COG1028	Short-chain dehydrogenase reductase Sdr
RD03_RS08460	COG0583	DNA-binding transcription factor activity
RD03_RS08475	COG3181	Tripartite tricarboxylate transporter family receptor
RD03_RS08480	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RD03_RS08480	COG2111	Na H antiporter
RD03_RS08485	COG1006	Multisubunit Na H antiporter MnhC subunit
RD03_RS08490	COG0651	ATP synthesis coupled electron transport
RD03_RS08495	COG1863	multisubunit Na H antiporter MnhE subunit
RD03_RS08500	COG2212	antiporter activity
RD03_RS08525	COG0590	tRNA wobble adenosine to inosine editing
RD03_RS08530	COG1619	proteins homologs of microcin C7 resistance protein MccF
RD03_RS08535	COG1024	Enoyl-CoA hydratase
RD03_RS08550	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD03_RS08555	COG0488	(ABC) transporter
RD03_RS08590	COG1017	nitric oxide dioxygenase activity
RD03_RS08590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RD03_RS08595	COG1959	2 iron, 2 sulfur cluster binding
RD03_RS08600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD03_RS08620	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RD03_RS08625	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RD03_RS08630	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RD03_RS08635	COG0084	hydrolase, TatD family'
RD03_RS08650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD03_RS08660	COG1126	abc transporter atp-binding protein
RD03_RS08665	COG0010	Belongs to the arginase family
RD03_RS08670	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RD03_RS08675	COG1012	belongs to the aldehyde dehydrogenase family
RD03_RS08685	COG0028	Belongs to the TPP enzyme family
RD03_RS08695	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD03_RS08695	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD03_RS08705	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD03_RS08720	COG3189	MarR family transcriptional regulator
RD03_RS08745	COG4336	lyase activity
RD03_RS08755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD03_RS08755	COG2205	protein histidine kinase activity
RD03_RS08760	COG2197	response regulator
RD03_RS08765	COG3064	Membrane
RD03_RS08765	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
RD03_RS08765	COG3210	domain, Protein
RD03_RS08775	COG3121	Chaperone
RD03_RS08780	COG3188	usher protein
RD03_RS08785	COG3539	Fimbrial protein
RD03_RS08790	COG2831	hemolysin activation secretion protein
RD03_RS08805	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD03_RS08830	COG0583	DNA-binding transcription factor activity
RD03_RS08855	COG0668	transmembrane transport
RD03_RS08875	COG0483	inositol monophosphate 1-phosphatase activity
RD03_RS08880	COG1253	flavin adenine dinucleotide binding
RD03_RS08885	COG1968	undecaprenyl-diphosphatase activity
RD03_RS08890	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RD03_RS08905	COG0215	cysteine-tRNA ligase activity
RD03_RS08915	COG0825	malonyl-CoA metabolic process
RD03_RS08925	COG0037	tRNA processing
RD03_RS08930	COG0527	aspartate kinase activity
RD03_RS08955	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD03_RS08960	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD03_RS08960	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD03_RS08975	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RD03_RS08980	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
RD03_RS08985	COG1028	Short-chain dehydrogenase reductase Sdr
RD03_RS08995	COG0583	DNA-binding transcription factor activity
RD03_RS09025	COG3842	ATPase activity
RD03_RS09035	COG1902	pentaerythritol trinitrate reductase activity
RD03_RS09035	COG0446	pyridine nucleotide-disulphide oxidoreductase
RD03_RS09040	COG1414	Transcriptional regulator
RD03_RS09045	COG1832	CoA-binding protein
RD03_RS09055	COG0251	oxidation-reduction process
RD03_RS09080	COG1902	pentaerythritol trinitrate reductase activity
RD03_RS09090	COG1215	transferase activity, transferring glycosyl groups
RD03_RS09095	COG0726	polysaccharide deacetylase
RD03_RS09095	COG1649	PFAM Uncharacterised BCR, COG1649
RD03_RS09115	COG1846	Transcriptional regulator
RD03_RS09135	COG0166	Belongs to the GPI family
RD03_RS09140	COG1045	serine acetyltransferase
RD03_RS09150	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RD03_RS09155	COG0483	inositol monophosphate 1-phosphatase activity
RD03_RS09160	COG1012	belongs to the aldehyde dehydrogenase family
RD03_RS09165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RD03_RS09180	COG0210	DNA helicase
RD03_RS09185	COG0598	Magnesium transport protein CorA
RD03_RS09195	COG0747	negative chemotaxis
RD03_RS09200	COG0601	transmembrane transport
RD03_RS09205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD03_RS09210	COG4172	Belongs to the ABC transporter superfamily
RD03_RS09215	COG1846	Transcriptional regulator
RD03_RS09265	COG4964	Belongs to the GSP D family
RD03_RS09305	COG2204	response regulator
RD03_RS09320	COG1595	DNA-templated transcription, initiation
RD03_RS09330	COG3474	cytochrome
RD03_RS09335	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RD03_RS09350	COG3384	dioxygenase
RD03_RS09355	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RD03_RS09380	COG2885	chlorophyll binding
RD03_RS09415	COG0697	spore germination
RD03_RS09420	COG0730	response to heat
RD03_RS09435	COG0583	DNA-binding transcription factor activity
RD03_RS09440	COG0427	acetyl-CoA hydrolase
RD03_RS09495	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD03_RS09500	COG0154	amidase activity
RD03_RS09510	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RD03_RS09525	COG0495	leucyl-tRNA aminoacylation
RD03_RS09530	COG2814	Major facilitator Superfamily
RD03_RS09560	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RD03_RS09565	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RD03_RS09570	COG2814	Major facilitator Superfamily
RD03_RS09575	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RD03_RS09590	COG4176	ABC-type proline glycine betaine transport system permease component
RD03_RS09600	COG1942	4-Oxalocrotonate Tautomerase
RD03_RS09605	COG0183	Belongs to the thiolase family
RD03_RS09615	COG1802	Transcriptional regulator
RD03_RS09625	COG1024	Enoyl-CoA hydratase
RD03_RS09640	COG2032	superoxide dismutase activity
RD03_RS09655	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RD03_RS09680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RD03_RS09685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RD03_RS09695	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
RD03_RS09700	COG0736	holo-[acyl-carrier-protein] synthase activity
RD03_RS09705	COG1472	Belongs to the glycosyl hydrolase 3 family
RD03_RS09710	COG0322	excinuclease ABC activity
RD03_RS09715	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RD03_RS09730	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RD03_RS09730	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RD03_RS09735	COG2224	Isocitrate lyase
RD03_RS09755	COG0559	Belongs to the binding-protein-dependent transport system permease family
RD03_RS09765	COG4638	Rieske (2fe-2S)
RD03_RS09775	COG1024	Enoyl-CoA hydratase
RD03_RS09785	COG0633	Ferredoxin
RD03_RS09790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD03_RS09805	COG0183	Belongs to the thiolase family
RD03_RS09815	COG4692	amylo-alpha-1,6-glucosidase activity
RD03_RS09820	COG0583	DNA-binding transcription factor activity
RD03_RS09845	COG2346	COG2346, Truncated hemoglobins
RD03_RS09970	COG2207	Transcriptional regulator
RD03_RS10015	COG1132	(ABC) transporter
RD03_RS10040	COG0659	secondary active sulfate transmembrane transporter activity
RD03_RS10070	COG2169	Transcriptional regulator
RD03_RS10075	COG5507	3-demethylubiquinone-9 3-methyltransferase
RD03_RS10080	COG0384	phenazine biosynthesis protein PhzF
RD03_RS10085	COG0583	DNA-binding transcription factor activity
RD03_RS10090	COG2733	membrane
RD03_RS10105	COG1012	belongs to the aldehyde dehydrogenase family
RD03_RS10110	COG3284	Transcriptional regulator
RD03_RS10125	COG1346	cytolysis
RD03_RS10130	COG1380	Effector of murein hydrolase LrgA
RD03_RS10135	COG4106	trans-aconitate 2-methyltransferase activity
RD03_RS10135	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RD03_RS10145	COG0156	8-amino-7-oxononanoate synthase activity
RD03_RS10215	COG1131	(ABC) transporter
RD03_RS10220	COG0842	Transport permease protein
RD03_RS10225	COG0628	permease
RD03_RS10255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RD03_RS10265	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RD03_RS10270	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
RD03_RS10275	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RD03_RS10280	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
RD03_RS10285	COG0330	HflC and HflK could
RD03_RS10290	COG0330	HflC and HflK could
RD03_RS10295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RD03_RS10300	COG1923	regulation of RNA biosynthetic process
RD03_RS10305	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RD03_RS10310	COG1160	GTP binding
RD03_RS10315	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RD03_RS10320	COG2976	Protein conserved in bacteria
RD03_RS10325	COG0124	histidyl-tRNA synthetase
RD03_RS10330	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RD03_RS10340	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RD03_RS10345	COG0105	UTP biosynthetic process
RD03_RS10350	COG0525	valine-tRNA ligase activity
RD03_RS10365	COG0642	Histidine kinase
RD03_RS10385	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RD03_RS10390	COG0336	Belongs to the RNA methyltransferase TrmD family
RD03_RS10395	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RD03_RS10400	COG0228	four-way junction DNA binding
RD03_RS10410	COG0425	Belongs to the sulfur carrier protein TusA family
RD03_RS10415	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RD03_RS10460	COG0154	amidase activity
RD03_RS10465	COG4172	Belongs to the ABC transporter superfamily
RD03_RS10470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD03_RS10475	COG0601	transmembrane transport
RD03_RS10480	COG0747	negative chemotaxis
RD03_RS10505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD03_RS10515	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
RD03_RS10530	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RD03_RS10535	COG3395	kinase activity
RD03_RS10550	COG1024	Enoyl-CoA hydratase
RD03_RS10570	COG0633	Ferredoxin
RD03_RS10575	COG0443	Heat shock 70 kDa protein
RD03_RS10580	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RD03_RS10585	COG0316	Belongs to the HesB IscA family
RD03_RS10590	COG0822	iron-sulfur transferase activity
RD03_RS10595	COG1104	cysteine desulfurase activity
RD03_RS10605	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RD03_RS10610	COG0556	nucleotide-excision repair
RD03_RS10620	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RD03_RS10625	COG3468	outer membrane autotransporter barrel domain protein
RD03_RS10650	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RD03_RS10665	COG1960	acyl-CoA dehydrogenase activity
RD03_RS10670	COG1028	Short-chain dehydrogenase reductase Sdr
RD03_RS10675	COG0183	Belongs to the thiolase family
RD03_RS10685	COG1024	Enoyl-CoA hydratase
RD03_RS10700	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD03_RS10705	COG0583	DNA-binding transcription factor activity
RD03_RS10710	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RD03_RS10715	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RD03_RS10720	COG0740	serine-type endopeptidase activity
RD03_RS10725	COG0544	peptidyl-prolyl cis-trans isomerase activity
RD03_RS10735	COG1278	Cold shock
RD03_RS10745	COG1278	Cold shock
RD03_RS10780	COG2171	N-acyltransferase activity
RD03_RS10785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RD03_RS10790	COG2890	protein-(glutamine-N5) methyltransferase activity
RD03_RS10795	COG0488	(ABC) transporter
RD03_RS10800	COG4771	TonB-dependent receptor
RD03_RS10805	COG0210	DNA helicase
RD03_RS10825	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RD03_RS10825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RD03_RS10830	COG0196	riboflavin kinase activity
RD03_RS10835	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RD03_RS10840	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RD03_RS10845	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RD03_RS10855	COG1522	sequence-specific DNA binding
RD03_RS10870	COG2951	lytic endotransglycosylase activity
RD03_RS10875	COG2833	Protein of unknown function (DUF455)
RD03_RS10895	COG0189	ligase activity
RD03_RS10895	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RD03_RS10900	COG1181	Belongs to the D-alanine--D-alanine ligase family
RD03_RS10900	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RD03_RS10905	COG3237	CsbD-like
RD03_RS10915	COG2823	Periplasmic or secreted lipoprotein
RD03_RS10925	COG4181	ATPase activity
RD03_RS10935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RD03_RS10940	COG0584	glycerophosphoryl diester phosphodiesterase
RD03_RS10945	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
RD03_RS10955	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RD03_RS10955	COG0678	peroxiredoxin activity
RD03_RS10965	COG0789	Transcriptional regulator
RD03_RS10970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RD03_RS11000	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
RD03_RS11005	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RD03_RS11015	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RD03_RS11020	COG2252	PERMEase
RD03_RS11030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RD03_RS11060	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RD03_RS11065	COG2358	TRAP transporter, solute receptor (TAXI family
RD03_RS11095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RD03_RS11100	COG1366	Belongs to the anti-sigma-factor antagonist family
RD03_RS11105	COG2172	sigma factor antagonist activity
RD03_RS11110	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RD03_RS11120	COG2770	Histidine kinase
RD03_RS11120	COG2208	phosphoserine phosphatase activity
RD03_RS11145	COG1595	DNA-templated transcription, initiation
RD03_RS11160	COG4792	protein secretion
RD03_RS11165	COG4791	protein targeting
RD03_RS11170	COG4794	Type iii secretion
RD03_RS11175	COG4790	Type iii secretion
RD03_RS11210	COG4669	(LipO)protein
RD03_RS11275	COG4789	Type iii secretion
RD03_RS11305	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RD03_RS11310	COG0840	transmembrane signaling receptor activity
RD03_RS11315	COG2233	PERMEase
RD03_RS11335	COG0492	ferredoxin-NADP+ reductase activity
RD03_RS11340	COG1840	ABC-type Fe3 transport system, periplasmic component
RD03_RS11345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RD03_RS11350	COG1178	ABC-type Fe3 transport system permease component
RD03_RS11355	COG3842	ATPase activity
RD03_RS11360	COG0583	DNA-binding transcription factor activity
RD03_RS11380	COG0501	Belongs to the peptidase M48B family
RD03_RS11390	COG0697	spore germination
RD03_RS11400	COG1846	Transcriptional regulator
RD03_RS11410	COG1566	PFAM secretion protein HlyD family protein
RD03_RS11415	COG2814	Major facilitator Superfamily
RD03_RS11420	COG0473	3-isopropylmalate dehydrogenase activity
RD03_RS11430	COG0747	negative chemotaxis
RD03_RS11440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD03_RS11455	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RD03_RS11480	COG1012	belongs to the aldehyde dehydrogenase family
RD03_RS11490	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RD03_RS11495	COG1115	amino acid carrier protein
RD03_RS11500	COG0433	COG0433 Predicted ATPase
RD03_RS11505	COG0217	transcriptional regulatory protein
RD03_RS11510	COG0151	Belongs to the GarS family
RD03_RS11515	COG0408	coproporphyrinogen oxidase activity
RD03_RS11520	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RD03_RS11525	COG0799	negative regulation of ribosome biogenesis
RD03_RS11530	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RD03_RS11535	COG0424	maF-like protein
RD03_RS11540	COG3468	outer membrane autotransporter barrel domain protein
RD03_RS11580	COG1530	ribonuclease E activity
RD03_RS11585	COG0077	Prephenate dehydratase
RD03_RS11600	COG1132	(ABC) transporter
RD03_RS11605	COG0859	PFAM glycosyl transferase family 9
RD03_RS11630	COG2194	sulfuric ester hydrolase activity
RD03_RS11635	COG0438	transferase activity, transferring glycosyl groups
RD03_RS11640	COG0463	Glycosyl transferase, family 2
RD03_RS11645	COG0726	polysaccharide deacetylase
RD03_RS11650	COG0438	transferase activity, transferring glycosyl groups
RD03_RS11665	COG1643	Atp-dependent helicase
RD03_RS11670	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RD03_RS11670	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RD03_RS11675	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
RD03_RS11685	COG0704	Plays a role in the regulation of phosphate uptake
RD03_RS11690	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
RD03_RS11695	COG1960	acyl-CoA dehydrogenase activity
RD03_RS11720	COG1177	transmembrane transport
RD03_RS11725	COG1176	ABC-type spermidine putrescine transport system, permease component I
RD03_RS11730	COG3842	ATPase activity
RD03_RS11735	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RD03_RS11750	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
RD03_RS11755	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD03_RS11765	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD03_RS11765	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD03_RS11785	COG0372	Belongs to the citrate synthase family
RD03_RS11790	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
RD03_RS11795	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RD03_RS11800	COG1053	succinate dehydrogenase
RD03_RS11805	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
RD03_RS11810	COG2009	succinate dehydrogenase
RD03_RS11815	COG2188	Transcriptional regulator
RD03_RS11820	COG0039	L-malate dehydrogenase activity
RD03_RS11850	COG1981	membrane
RD03_RS11875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RD03_RS11885	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
RD03_RS11915	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
RD03_RS11920	COG0148	phosphopyruvate hydratase activity
RD03_RS11930	COG2877	3-deoxy-8-phosphooctulonate synthase activity
RD03_RS11935	COG0504	CTP synthase activity
RD03_RS11960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD03_RS11970	COG0747	negative chemotaxis
RD03_RS11975	COG4172	Belongs to the ABC transporter superfamily
RD03_RS11980	COG1446	asparaginase
RD03_RS12010	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RD03_RS12025	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
RD03_RS12030	COG0697	spore germination
RD03_RS12035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RD03_RS12045	COG3193	protein, possibly involved in utilization of glycolate and propanediol
RD03_RS12050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RD03_RS12055	COG0791	NLP P60 protein
RD03_RS12070	COG0583	DNA-binding transcription factor activity
RD03_RS12085	COG0583	DNA-binding transcription factor activity
RD03_RS12095	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RD03_RS12110	COG0670	Belongs to the BI1 family
RD03_RS12115	COG3181	Tripartite tricarboxylate transporter family receptor
RD03_RS12130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RD03_RS12140	COG1381	Involved in DNA repair and RecF pathway recombination
RD03_RS12145	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RD03_RS12150	COG0571	ribonuclease III activity
RD03_RS12155	COG0681	Belongs to the peptidase S26 family
RD03_RS12160	COG0481	GTPase activity
RD03_RS12165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RD03_RS12190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RD03_RS12195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RD03_RS12210	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RD03_RS12215	COG0416	fatty acid biosynthetic process
RD03_RS12220	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RD03_RS12225	COG1399	metal-binding, possibly nucleic acid-binding protein
RD03_RS12230	COG0424	maF-like protein
RD03_RS12240	COG3023	N-Acetylmuramoyl-L-alanine amidase
RD03_RS12255	COG3022	response to hydroperoxide
RD03_RS12265	COG1028	Short-chain dehydrogenase reductase Sdr
RD03_RS12280	COG3486	L-lysine 6-monooxygenase (NADPH) activity
RD03_RS12310	COG2814	Major facilitator Superfamily
RD03_RS12330	COG3706	GGDEF domain
RD03_RS12355	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RD03_RS12360	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RD03_RS12365	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
RD03_RS12370	COG1674	ftsk spoiiie
RD03_RS12375	COG0492	ferredoxin-NADP+ reductase activity
RD03_RS12380	COG1193	negative regulation of DNA recombination
RD03_RS12400	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RD03_RS12410	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
RD03_RS12415	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
RD03_RS12420	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
RD03_RS12425	COG2205	protein histidine kinase activity
RD03_RS12430	COG0745	RESPONSE REGULATOR receiver
RD03_RS12475	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RD03_RS12495	COG0612	Peptidase, M16
RD03_RS12505	COG0443	Heat shock 70 kDa protein
RD03_RS12515	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RD03_RS12525	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RD03_RS12530	COG1420	regulation of RNA biosynthetic process
RD03_RS12535	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RD03_RS12540	COG0497	DNA recombination
RD03_RS12545	COG0735	belongs to the Fur family
RD03_RS12550	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RD03_RS12555	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RD03_RS12560	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RD03_RS12595	COG0446	pyridine nucleotide-disulphide oxidoreductase
RD03_RS12595	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RD03_RS12600	COG4311	Sarcosine oxidase, delta subunit
RD03_RS12605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD03_RS12615	COG0583	DNA-binding transcription factor activity
RD03_RS12625	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RD03_RS12655	COG4964	Belongs to the GSP D family
RD03_RS12715	COG0181	hydroxymethylbilane synthase activity
RD03_RS12720	COG0861	Integral membrane protein TerC family
RD03_RS12725	COG0861	Integral membrane protein TerC family
RD03_RS12730	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RD03_RS12735	COG0045	succinate-CoA ligase (ADP-forming) activity
RD03_RS12745	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
RD03_RS12755	COG2137	regulation of response to DNA damage stimulus
RD03_RS12760	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RD03_RS12780	COG1024	Enoyl-CoA hydratase
RD03_RS12780	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD03_RS12785	COG3842	ATPase activity
RD03_RS12800	COG1028	Short-chain dehydrogenase reductase Sdr
RD03_RS12820	COG0583	DNA-binding transcription factor activity
RD03_RS12825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD03_RS12835	COG2974	May be involved in recombination
RD03_RS12840	COG0540	Belongs to the ATCase OTCase family
RD03_RS12910	COG0776	regulation of translation
RD03_RS12915	COG0072	phenylalanine-tRNA ligase activity
RD03_RS12915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RD03_RS12920	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RD03_RS12925	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RD03_RS12930	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RD03_RS12940	COG0756	dUTP diphosphatase activity
RD03_RS12950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RD03_RS12965	COG0500	methyltransferase
RD03_RS12975	COG0586	Pfam SNARE associated Golgi protein
RD03_RS13000	COG1609	Transcriptional regulator
RD03_RS13005	COG4172	Belongs to the ABC transporter superfamily
RD03_RS13010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD03_RS13015	COG0601	transmembrane transport
RD03_RS13020	COG0747	negative chemotaxis
RD03_RS13035	COG1280	lysine exporter protein (LysE YggA)
RD03_RS13050	COG2814	Major facilitator Superfamily
RD03_RS13080	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
RD03_RS13095	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
RD03_RS13130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD03_RS13135	COG1116	anion transmembrane transporter activity
RD03_RS13145	COG1228	amidohydrolase
RD03_RS13160	COG0477	Major facilitator Superfamily
RD03_RS13170	COG3550	peptidyl-serine autophosphorylation
RD03_RS13180	COG0519	Catalyzes the synthesis of GMP from XMP
RD03_RS13180	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RD03_RS13205	COG2197	response regulator
RD03_RS13230	COG0420	3'-5' exonuclease activity
RD03_RS13235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD03_RS13265	COG0395	ABC-type sugar transport system, permease component
RD03_RS13275	COG3842	ATPase activity
RD03_RS13305	COG3181	Tripartite tricarboxylate transporter family receptor
RD03_RS13340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RD03_RS13365	COG0602	queuosine metabolic process
RD03_RS13370	COG0720	synthase
RD03_RS13375	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD03_RS13380	COG0235	Class ii aldolase
RD03_RS13405	COG3210	domain, Protein
RD03_RS13405	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
RD03_RS13405	COG3064	Membrane
RD03_RS13410	COG0047	phosphoribosylformylglycinamidine synthase activity
RD03_RS13410	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RD03_RS13415	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD03_RS13420	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD03_RS13420	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD03_RS13425	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD03_RS13440	COG3539	Fimbrial protein
RD03_RS13450	COG2050	protein possibly involved in aromatic compounds catabolism
RD03_RS13455	COG1024	Enoyl-CoA hydratase
RD03_RS13460	COG1012	belongs to the aldehyde dehydrogenase family
RD03_RS13470	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RD03_RS13475	COG2151	metal-sulfur cluster biosynthetic enzyme
RD03_RS13480	COG3396	Phenylacetate-CoA oxygenase
RD03_RS13485	COG3460	Phenylacetate-CoA oxygenase
RD03_RS13490	COG3396	Phenylacetate-CoA oxygenase
RD03_RS13495	COG3327	negative regulation of DNA-templated transcription, initiation
RD03_RS13505	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
RD03_RS13510	COG0501	Belongs to the peptidase M48B family
RD03_RS13515	COG1162	GTPase activity
RD03_RS13520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD03_RS13525	COG0601	transmembrane transport
RD03_RS13530	COG0747	negative chemotaxis
RD03_RS13575	COG0668	transmembrane transport
RD03_RS13580	COG0165	Argininosuccinate lyase
RD03_RS13600	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RD03_RS13605	COG0303	'Molybdopterin
RD03_RS13610	COG0521	Mo-molybdopterin cofactor biosynthetic process
RD03_RS13625	COG0315	cyclic pyranopterin monophosphate synthase activity
RD03_RS13635	COG0412	Dienelactone hydrolase
RD03_RS13645	COG0678	peroxiredoxin activity
RD03_RS13655	COG0697	spore germination
RD03_RS13660	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RD03_RS13685	COG0789	Transcriptional regulator
RD03_RS13705	COG1028	Short-chain dehydrogenase reductase Sdr
RD03_RS13715	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RD03_RS13720	COG1845	cytochrome c oxidase, subunit III
RD03_RS13725	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RD03_RS13735	COG0477	Major facilitator Superfamily
RD03_RS13765	COG3468	outer membrane autotransporter barrel domain protein
RD03_RS13775	COG1309	transcriptional regulator
RD03_RS13780	COG2271	Major facilitator Superfamily
RD03_RS13815	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RD03_RS13815	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RD03_RS13815	COG0506	proline dehydrogenase activity
RD03_RS13825	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RD03_RS13825	COG3008	intermembrane lipid transfer
RD03_RS13830	COG2995	paraquat-inducible protein a
RD03_RS13835	COG0542	response to heat
RD03_RS13840	COG4953	penicillin-binding protein 1C
RD03_RS13850	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RD03_RS13855	COG1278	Cold shock
RD03_RS13865	COG0183	Belongs to the thiolase family
RD03_RS13870	COG0038	chloride channel
RD03_RS13875	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RD03_RS13880	COG1570	exodeoxyribonuclease VII activity
RD03_RS13890	COG0811	peptide transport
RD03_RS13895	COG0848	biopolymer transport protein
RD03_RS13900	COG1663	tetraacyldisaccharide 4'-kinase activity
RD03_RS13905	COG2835	tetraacyldisaccharide 4'-kinase activity
RD03_RS13910	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
RD03_RS13915	COG0563	adenylate kinase activity
RD03_RS13925	COG0728	peptidoglycan biosynthetic process
RD03_RS13935	COG0268	Binds directly to 16S ribosomal RNA
RD03_RS13965	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RD03_RS13990	COG0436	Aminotransferase
RD03_RS13995	COG3737	Protein of unknown function (DUF498/DUF598)
RD03_RS14000	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RD03_RS14005	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
RD03_RS14010	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RD03_RS14020	COG0305	Participates in initiation and elongation during chromosome replication
RD03_RS14030	COG0359	binds to the 23S rRNA
RD03_RS14035	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RD03_RS14040	COG2965	DNA replication, synthesis of RNA primer
RD03_RS14045	COG0360	Binds together with S18 to 16S ribosomal RNA
RD03_RS14050	COG1469	GTP cyclohydrolase I activity
RD03_RS14055	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RD03_RS14060	COG0142	geranyltranstransferase activity
RD03_RS14065	COG1722	exodeoxyribonuclease VII activity
RD03_RS14075	COG3181	Tripartite tricarboxylate transporter family receptor
RD03_RS14095	COG2239	Acts as a magnesium transporter
RD03_RS14105	COG2855	membrane
RD03_RS14115	COG1473	amidohydrolase
RD03_RS14120	COG0318	PFAM AMP-dependent synthetase and ligase
RD03_RS14140	COG1501	Belongs to the glycosyl hydrolase 31 family
RD03_RS14145	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RD03_RS14150	COG2011	ABC-type metal ion transport system permease component
RD03_RS14170	COG1454	alcohol dehydrogenase
RD03_RS14195	COG2186	Transcriptional regulator
RD03_RS14200	COG3181	Tripartite tricarboxylate transporter family receptor
RD03_RS14220	COG1175	transmembrane transport
RD03_RS14225	COG0395	ABC-type sugar transport system, permease component
RD03_RS14230	COG3842	ATPase activity
RD03_RS14235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RD03_RS14245	COG1653	transport
RD03_RS14265	COG2818	Glycosylase
RD03_RS14270	COG2982	Protein involved in outer membrane biogenesis
RD03_RS14280	COG1309	transcriptional regulator
RD03_RS14285	COG1028	Short-chain dehydrogenase reductase Sdr
RD03_RS14325	COG0583	DNA-binding transcription factor activity
RD03_RS14330	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
RD03_RS14335	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RD03_RS14350	COG1028	Short-chain dehydrogenase reductase Sdr
RD03_RS14355	COG0477	Major facilitator Superfamily
RD03_RS14365	COG0583	DNA-binding transcription factor activity
RD03_RS14370	COG1448	Aminotransferase
RD03_RS14375	COG1418	mRNA catabolic process
RD03_RS14400	COG1063	alcohol dehydrogenase
RD03_RS14420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD03_RS14430	COG0318	PFAM AMP-dependent synthetase and ligase
RD03_RS14440	COG1522	sequence-specific DNA binding
RD03_RS14445	COG3181	Tripartite tricarboxylate transporter family receptor
RD03_RS14450	COG0307	riboflavin synthase, alpha
RD03_RS14455	COG0154	amidase activity
RD03_RS14475	COG2807	transmembrane transport
RD03_RS14480	COG0590	tRNA wobble adenosine to inosine editing
RD03_RS14490	COG0583	DNA-binding transcription factor activity
RD03_RS14505	COG1902	pentaerythritol trinitrate reductase activity
RD03_RS14525	COG0559	Belongs to the binding-protein-dependent transport system permease family
RD03_RS14530	COG0251	oxidation-reduction process
RD03_RS14535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RD03_RS14545	COG1414	Transcriptional regulator
RD03_RS14550	COG1028	Short-chain dehydrogenase reductase Sdr
RD03_RS14565	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD03_RS14580	COG1024	Enoyl-CoA hydratase
RD03_RS14585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD03_RS14590	COG0154	amidase activity
RD03_RS14630	COG3909	cytochrome
RD03_RS14635	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RD03_RS14640	COG0625	glutathione transferase activity
RD03_RS14645	COG0730	response to heat
RD03_RS14650	COG0482	sulfurtransferase activity
RD03_RS14655	COG0583	DNA-binding transcription factor activity
RD03_RS14690	COG2819	hydrolase of the alpha beta superfamily
RD03_RS14695	COG0247	lactate metabolic process
RD03_RS14700	COG0277	FAD linked oxidase domain protein
RD03_RS14705	COG0277	FAD linked oxidase domain protein
RD03_RS14710	COG0277	FAD linked oxidase domain protein
RD03_RS14715	COG3064	Membrane
RD03_RS14715	COG3210	domain, Protein
RD03_RS14715	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
RD03_RS14715	COG3064	Membrane
RD03_RS14715	COG3210	domain, Protein
RD03_RS14715	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
RD03_RS14720	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RD03_RS14725	COG0312	modulator of DNA gyrase
RD03_RS14760	COG1666	GTP binding
RD03_RS14805	COG3220	belongs to the UPF0276 family
RD03_RS14825	COG0640	Transcriptional regulator
RD03_RS14830	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RD03_RS14835	COG1845	cytochrome c oxidase, subunit III
RD03_RS14840	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RD03_RS14850	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
RD03_RS14885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD03_RS14890	COG0583	DNA-binding transcription factor activity
RD03_RS14920	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RD03_RS14920	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RD03_RS14935	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RD03_RS14940	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RD03_RS14950	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RD03_RS14965	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
RD03_RS14970	COG0316	Belongs to the HesB IscA family
RD03_RS14980	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RD03_RS14985	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RD03_RS14990	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RD03_RS14995	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD03_RS15000	COG0312	modulator of DNA gyrase
RD03_RS15005	COG3028	Belongs to the UPF0307 family
RD03_RS15020	COG1116	anion transmembrane transporter activity
RD03_RS15025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD03_RS15030	COG1335	isochorismatase
RD03_RS15035	COG0346	lactoylglutathione lyase activity
RD03_RS15040	COG0513	Belongs to the DEAD box helicase family
RD03_RS15045	COG3069	C4-dicarboxylate transmembrane transporter activity
RD03_RS15050	COG1802	Transcriptional regulator
RD03_RS15060	COG1042	CoA-binding domain protein
RD03_RS15060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RD03_RS15060	COG0045	succinate-CoA ligase (ADP-forming) activity
RD03_RS15065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RD03_RS15080	COG1522	sequence-specific DNA binding
RD03_RS15115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RD03_RS15120	COG1696	Membrane protein involved in D-alanine export
RD03_RS15145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RD03_RS15155	COG2264	protein methyltransferase activity
RD03_RS15160	COG0439	Biotin carboxylase
RD03_RS15165	COG0511	ligase activity, forming carbon-carbon bonds
RD03_RS15170	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RD03_RS15175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RD03_RS15180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RD03_RS15185	COG3150	esterase
RD03_RS15190	COG0557	exoribonuclease II activity
RD03_RS15200	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RD03_RS15220	COG1522	sequence-specific DNA binding
RD03_RS15225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD03_RS15230	COG1028	Short-chain dehydrogenase reductase Sdr
RD03_RS15250	COG0653	protein targeting
RD03_RS15255	COG0739	heme binding
RD03_RS15265	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
RD03_RS15270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RD03_RS15280	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RD03_RS15285	COG1181	Belongs to the D-alanine--D-alanine ligase family
RD03_RS15290	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RD03_RS15295	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RD03_RS15305	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RD03_RS15310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RD03_RS15315	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RD03_RS15325	COG3116	cell division
RD03_RS15330	COG0275	rRNA processing
RD03_RS15335	COG2001	Belongs to the MraZ family
RD03_RS15345	COG0488	(ABC) transporter
RD03_RS15350	COG0418	dihydroorotase activity
RD03_RS15355	COG1473	amidohydrolase
RD03_RS15405	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RD03_RS15410	COG4654	Cytochrome c, class I
RD03_RS15415	COG0129	dihydroxy-acid dehydratase activity
RD03_RS15420	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RD03_RS15470	COG2084	Dehydrogenase
RD03_RS15475	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RD03_RS15490	COG2096	Adenosyltransferase
RD03_RS15500	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
RD03_RS15505	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
RD03_RS15515	COG0523	cobalamin synthesis protein
RD03_RS15520	COG0735	belongs to the Fur family
RD03_RS15540	COG0803	Belongs to the bacterial solute-binding protein 9 family
RD03_RS15550	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
RD03_RS15560	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
RD03_RS15570	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RD03_RS15575	COG1560	Kdo2-lipid A biosynthetic process
RD03_RS15585	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RD03_RS15600	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
RD03_RS15605	COG1950	PFAM Membrane protein of
RD03_RS15620	COG0583	DNA-binding transcription factor activity
RD03_RS15630	COG0477	Major facilitator Superfamily
RD03_RS15645	COG0617	tRNA 3'-terminal CCA addition
RD03_RS15655	COG0513	Belongs to the DEAD box helicase family
RD03_RS15660	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RD03_RS15670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RD03_RS15675	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
RD03_RS15735	COG1280	lysine exporter protein (LysE YggA)
RD03_RS15750	COG0405	Gamma-glutamyltransferase
RD03_RS15760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD03_RS15785	COG1309	transcriptional regulator
RD03_RS15800	COG0745	RESPONSE REGULATOR receiver
RD03_RS15845	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RD03_RS15865	COG0582	viral genome integration into host DNA
RD03_RS15870	COG0012	GTP binding
RD03_RS15880	COG0193	aminoacyl-tRNA hydrolase activity
RD03_RS15885	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RD03_RS15890	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RD03_RS15900	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RD03_RS15905	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
RD03_RS15915	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RD03_RS15940	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
RD03_RS15950	COG1368	sulfuric ester hydrolase activity
RD03_RS15955	COG0642	Histidine kinase
RD03_RS15960	COG0745	RESPONSE REGULATOR receiver
RD03_RS15965	COG0277	FAD linked oxidase domain protein
RD03_RS15980	COG0166	Belongs to the GPI family
RD03_RS15985	COG0438	transferase activity, transferring glycosyl groups
RD03_RS15990	COG0438	transferase activity, transferring glycosyl groups
RD03_RS16005	COG0438	transferase activity, transferring glycosyl groups
RD03_RS16020	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
RD03_RS16025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RD03_RS16030	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
RD03_RS16040	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RD03_RS16050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RD03_RS16055	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RD03_RS16065	COG0747	negative chemotaxis
RD03_RS16070	COG0601	transmembrane transport
RD03_RS16075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD03_RS16095	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RD03_RS16100	COG0830	nickel cation binding
RD03_RS16110	COG0804	urea catabolic process
RD03_RS16115	COG0832	Belongs to the urease beta subunit family
RD03_RS16125	COG0831	urea catabolic process
RD03_RS16130	COG0829	nickel cation binding
RD03_RS16140	COG0633	Ferredoxin
RD03_RS16155	COG2188	Transcriptional regulator
RD03_RS16180	COG2719	SpoVR family
RD03_RS16185	COG2718	Belongs to the UPF0229 family
RD03_RS16200	COG1028	Short-chain dehydrogenase reductase Sdr
RD03_RS16205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD03_RS16220	COG1960	acyl-CoA dehydrogenase activity
RD03_RS16265	COG0183	Belongs to the thiolase family
RD03_RS16270	COG2030	dehydratase
RD03_RS16315	COG0328	RNA-DNA hybrid ribonuclease activity
RD03_RS16320	COG2226	methyltransferase
RD03_RS16325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RD03_RS16330	COG0741	lytic transglycosylase activity
RD03_RS16330	COG1388	LysM domain
RD03_RS16350	COG2979	Protein of unknown function (DUF533)
RD03_RS16385	COG1271	oxidase subunit
RD03_RS16390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RD03_RS16395	COG0850	regulation of cytokinetic process
RD03_RS16400	COG2894	cell division
RD03_RS16405	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
RD03_RS16425	COG0488	(ABC) transporter
RD03_RS16435	COG0601	transmembrane transport
RD03_RS16445	COG1215	transferase activity, transferring glycosyl groups
RD03_RS16460	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RD03_RS16470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RD03_RS16490	COG0318	PFAM AMP-dependent synthetase and ligase
RD03_RS16495	COG2188	Transcriptional regulator
RD03_RS16500	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RD03_RS16505	COG2814	Major facilitator Superfamily
RD03_RS16515	COG0259	pyridoxamine-phosphate oxidase activity
RD03_RS16520	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RD03_RS16535	COG0583	DNA-binding transcription factor activity
RD03_RS16540	COG1960	acyl-CoA dehydrogenase activity
RD03_RS16565	COG0134	indole-3-glycerol-phosphate synthase activity
RD03_RS16570	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RD03_RS16575	COG0512	Glutamine amidotransferase of anthranilate synthase
RD03_RS16585	COG0546	phosphoglycolate phosphatase activity
RD03_RS16590	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RD03_RS16595	COG2967	ApaG domain
RD03_RS16600	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
RD03_RS16605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RD03_RS16610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RD03_RS16615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RD03_RS16625	COG0037	tRNA processing
RD03_RS16635	COG3634	alkyl hydroperoxide reductase activity
RD03_RS16640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RD03_RS16645	COG1024	Enoyl-CoA hydratase
RD03_RS16670	COG0356	it plays a direct role in the translocation of protons across the membrane
RD03_RS16680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RD03_RS16685	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RD03_RS16690	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RD03_RS16695	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RD03_RS16700	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RD03_RS16705	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RD03_RS16715	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
RD03_RS16720	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RD03_RS16725	COG0210	DNA helicase
RD03_RS16735	COG2195	Cleaves the N-terminal amino acid of tripeptides
RD03_RS16745	COG4608	Belongs to the ABC transporter superfamily
RD03_RS16750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD03_RS16755	COG0601	transmembrane transport
RD03_RS16775	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RD03_RS16780	COG1024	Enoyl-CoA hydratase
RD03_RS16785	COG1024	Enoyl-CoA hydratase
RD03_RS16810	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD03_RS16840	COG2132	Multicopper oxidase
RD03_RS16850	COG1024	Enoyl-CoA hydratase
RD03_RS16850	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD03_RS16865	COG1414	Transcriptional regulator
RD03_RS16875	COG0154	amidase activity
RD03_RS16905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RD03_RS16910	COG3568	Endonuclease Exonuclease Phosphatase
RD03_RS16915	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RD03_RS16950	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
RD03_RS16960	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
RD03_RS16975	COG1137	ATPase activity
RD03_RS16980	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RD03_RS16990	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
RD03_RS16995	COG2010	Cytochrome c
RD03_RS16995	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RD03_RS17005	COG1660	Displays ATPase and GTPase activities
RD03_RS17010	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RD03_RS17050	COG3181	Tripartite tricarboxylate transporter family receptor
RD03_RS17060	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
RD03_RS17065	COG2890	protein-(glutamine-N5) methyltransferase activity
RD03_RS17070	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RD03_RS17075	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RD03_RS17120	COG1960	acyl-CoA dehydrogenase activity
RD03_RS17130	COG0183	Belongs to the thiolase family
RD03_RS17135	COG1522	sequence-specific DNA binding
RD03_RS17140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RD03_RS17160	COG1024	Enoyl-CoA hydratase
RD03_RS17175	COG0604	alcohol dehydrogenase
RD03_RS17180	COG2072	flavoprotein involved in K transport
RD03_RS17195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RD03_RS17205	COG1960	acyl-CoA dehydrogenase activity
RD03_RS17210	COG1960	acyl-CoA dehydrogenase activity
RD03_RS17215	COG0277	FAD linked oxidase domain protein
RD03_RS17225	COG3181	Tripartite tricarboxylate transporter family receptor
RD03_RS17250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RD03_RS17260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD03_RS17265	COG3181	Tripartite tricarboxylate transporter family receptor
RD03_RS17270	COG1960	acyl-CoA dehydrogenase activity
RD03_RS17290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RD03_RS17295	COG1024	Enoyl-CoA hydratase
RD03_RS17300	COG1960	acyl-CoA dehydrogenase activity
RD03_RS17320	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RD03_RS17325	COG0022	dehydrogenase e1 component
RD03_RS17330	COG1024	Enoyl-CoA hydratase
RD03_RS17335	COG0508	dehydrogenase complex catalyzes the overall conversion of
RD03_RS17355	COG0683	leucine binding
RD03_RS17360	COG0559	Belongs to the binding-protein-dependent transport system permease family
RD03_RS17365	COG0411	ABC transporter
RD03_RS17375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RD03_RS17390	COG3181	Tripartite tricarboxylate transporter family receptor
RD03_RS17415	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RD03_RS17420	COG0793	Belongs to the peptidase S41A family
RD03_RS17425	COG4942	peptidase
RD03_RS17430	COG0588	phosphoglycerate mutase activity
RD03_RS17435	COG1054	Belongs to the UPF0176 family
RD03_RS17440	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RD03_RS17445	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
RD03_RS17450	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RD03_RS17455	COG3181	Tripartite tricarboxylate transporter family receptor
RD03_RS17470	COG2226	methyltransferase
RD03_RS17475	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
RD03_RS17490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD03_RS17495	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
RD03_RS17520	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD03_RS17545	COG1335	isochorismatase
RD03_RS17550	COG2309	aminopeptidase activity
RD03_RS17555	COG0596	Alpha beta hydrolase
RD03_RS17560	COG3473	Maleate cis-trans isomerase
RD03_RS17570	COG2068	MobA-Related Protein
RD03_RS17595	COG2204	response regulator
RD03_RS17600	COG5000	phosphorelay sensor kinase activity
RD03_RS17610	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RD03_RS17610	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RD03_RS17620	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
RD03_RS17645	COG0583	DNA-binding transcription factor activity
RD03_RS17660	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RD03_RS17665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RD03_RS17670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD03_RS17685	COG0758	DNA mediated transformation
RD03_RS17690	COG1522	sequence-specific DNA binding
RD03_RS17700	COG0242	peptide deformylase activity
RD03_RS17710	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RD03_RS17720	COG0546	phosphoglycolate phosphatase activity
RD03_RS17740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RD03_RS17745	COG1942	4-Oxalocrotonate Tautomerase
RD03_RS17750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD03_RS17770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RD03_RS17790	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RD03_RS17795	COG1024	Enoyl-CoA hydratase
RD03_RS17800	COG1414	Transcriptional regulator
RD03_RS17805	COG0318	PFAM AMP-dependent synthetase and ligase
RD03_RS17810	COG3181	Tripartite tricarboxylate transporter family receptor
RD03_RS17840	COG0583	DNA-binding transcription factor activity
RD03_RS17855	COG3422	double-strand break repair
RD03_RS17860	COG0330	HflC and HflK could
RD03_RS17870	COG0251	oxidation-reduction process
RD03_RS17915	COG3723	Recombinational DNA repair protein, rece pathway
RD03_RS17950	COG0582	viral genome integration into host DNA
RD03_RS17975	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RD03_RS17985	COG0706	membrane insertase activity
RD03_RS17990	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RD03_RS17995	COG0594	ribonuclease P activity
RD03_RS18000	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RD03_RS18005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RD03_RS18020	COG1414	Transcriptional regulator
RD03_RS18025	COG0154	amidase activity
RD03_RS18040	COG1304	FMN binding
RD03_RS18065	COG1960	acyl-CoA dehydrogenase activity
RD03_RS18085	COG1960	acyl-CoA dehydrogenase activity
RD03_RS18095	COG0183	Belongs to the thiolase family
RD03_RS18100	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RD03_RS18115	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RD03_RS18120	COG3181	Tripartite tricarboxylate transporter family receptor
RD03_RS18130	COG2358	TRAP transporter, solute receptor (TAXI family
RD03_RS18140	COG1629	transport
RD03_RS18145	COG2922	Belongs to the Smg family
RD03_RS18170	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
RD03_RS18175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD03_RS18180	COG1028	Short-chain dehydrogenase reductase Sdr
RD03_RS18185	COG1012	belongs to the aldehyde dehydrogenase family
RD03_RS18195	COG0028	Belongs to the TPP enzyme family
RD03_RS18200	COG1522	sequence-specific DNA binding
RD03_RS18205	COG3781	membrane
RD03_RS18215	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RD03_RS18235	COG4206	TonB-dependent receptor
RD03_RS18240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RD03_RS18245	COG2022	thiamine diphosphate biosynthetic process
RD03_RS18250	COG0351	phosphomethylpyrimidine kinase
RD03_RS18255	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RD03_RS18270	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RD03_RS18280	COG0628	permease
RD03_RS18290	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RD03_RS18300	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RD03_RS18305	COG0049	tRNA binding
RD03_RS18310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RD03_RS18315	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RD03_RS18320	COG0051	transcription antitermination factor activity, RNA binding
RD03_RS18325	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RD03_RS18330	COG0088	Forms part of the polypeptide exit tunnel
RD03_RS18335	COG0089	rRNA binding
RD03_RS18340	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RD03_RS18345	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RD03_RS18350	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RD03_RS18355	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RD03_RS18360	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RD03_RS18365	COG0255	Belongs to the universal ribosomal protein uL29 family
RD03_RS18370	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RD03_RS18390	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RD03_RS18395	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RD03_RS18400	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RD03_RS18405	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RD03_RS18410	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RD03_RS18415	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RD03_RS18420	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RD03_RS18425	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RD03_RS18430	COG1841	ribosomal large subunit assembly
RD03_RS18435	COG0200	Binds to the 23S rRNA
RD03_RS18440	COG0201	protein transport
RD03_RS18445	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RD03_RS18450	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RD03_RS18455	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RD03_RS18460	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RD03_RS18465	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RD03_RS18470	COG0202	RNA polymerase activity
RD03_RS18475	COG0203	ribosomal protein L17
RD03_RS18485	COG1324	tolerance protein
RD03_RS18490	COG4232	protein-disulfide reductase activity
RD03_RS18505	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RD03_RS18515	COG1333	cytochrome c biogenesis protein
RD03_RS18520	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RD03_RS18530	COG1965	Belongs to the frataxin family
RD03_RS18540	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RD03_RS18545	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RD03_RS18550	COG0232	Belongs to the dGTPase family. Type 2 subfamily
RD03_RS18565	COG2814	Major facilitator Superfamily
RD03_RS18570	COG0629	single-stranded DNA binding
RD03_RS18610	COG0402	S-adenosylhomocysteine deaminase activity
RD03_RS18620	COG0438	transferase activity, transferring glycosyl groups
RD03_RS18640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD03_RS18665	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RD03_RS18670	COG2186	Transcriptional regulator
RD03_RS18690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RD03_RS18695	COG1956	GAF domain-containing protein
RD03_RS18700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RD03_RS18710	COG1652	LysM domain
RD03_RS18725	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RD03_RS18740	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RD03_RS18765	COG3181	Tripartite tricarboxylate transporter family receptor
RD03_RS18780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD03_RS18795	COG1024	Enoyl-CoA hydratase
RD03_RS18810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD03_RS18815	COG1309	transcriptional regulator
RD03_RS18820	COG2816	NAD+ diphosphatase activity
RD03_RS18825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RD03_RS18910	COG2814	Major facilitator Superfamily
RD03_RS18915	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RD03_RS18935	COG1999	signal sequence binding
RD03_RS18940	COG0109	protoheme IX farnesyltransferase activity
RD03_RS18980	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RD03_RS19000	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RD03_RS19005	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RD03_RS19015	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
RD03_RS19020	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
RD03_RS19030	COG0069	glutamate synthase activity
RD03_RS19030	COG0067	glutamate synthase
RD03_RS19030	COG0070	glutamate synthase
RD03_RS19040	COG3047	cAMP biosynthetic process
RD03_RS19050	COG1127	ABC transporter
RD03_RS19055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RD03_RS19060	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RD03_RS19065	COG2853	Lipoprotein
RD03_RS19075	COG1131	(ABC) transporter
RD03_RS19080	COG0842	Transport permease protein
RD03_RS19090	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RD03_RS19095	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RD03_RS19100	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RD03_RS19105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RD03_RS19110	COG0131	Imidazoleglycerol-phosphate dehydratase
RD03_RS19115	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RD03_RS19120	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RD03_RS19125	COG0107	imidazoleglycerol-phosphate synthase activity
RD03_RS19130	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RD03_RS19135	COG0140	phosphoribosyl-ATP diphosphatase activity
RD03_RS19140	COG0537	adenosine 5'-monophosphoramidase activity
RD03_RS19145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RD03_RS19150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RD03_RS19165	COG3181	Tripartite tricarboxylate transporter family receptor
RD03_RS19200	COG3702	type iv secretory pathway
RD03_RS19205	COG3451	type IV secretory pathway VirB4
RD03_RS19220	COG3736	Type IV secretory pathway, component VirB8
RD03_RS19225	COG3504	Conjugal transfer protein
RD03_RS19230	COG2948	multi-organism process
RD03_RS19235	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
RD03_RS19245	COG0697	spore germination
RD03_RS19265	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RD03_RS19270	COG0747	negative chemotaxis
RD03_RS19275	COG0601	transmembrane transport
RD03_RS19280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD03_RS19285	COG0444	Belongs to the ABC transporter superfamily
RD03_RS19295	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
RD03_RS19305	COG0494	nUDIX hydrolase
RD03_RS19345	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
RD03_RS19350	COG0237	dephospho-CoA kinase activity
RD03_RS19355	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
RD03_RS19370	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RD03_RS19375	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
RD03_RS19385	COG0477	Major facilitator Superfamily
RD03_RS19390	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RD03_RS19405	COG1126	abc transporter atp-binding protein
RD03_RS19410	COG0765	amino acid transport
RD03_RS19415	COG4597	amino acid ABC transporter
RD03_RS19420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD03_RS19425	COG2884	Cell division ATP-binding protein ftsE
RD03_RS19430	COG2177	Part of the ABC transporter FtsEX involved in
RD03_RS19435	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
RD03_RS19445	COG1194	a g-specific adenine glycosylase
RD03_RS19455	COG2226	methyltransferase
RD03_RS19465	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD03_RS19470	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD03_RS19485	COG1024	Enoyl-CoA hydratase
RD03_RS19505	COG1024	Enoyl-CoA hydratase
RD03_RS19510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD03_RS19515	COG3181	Tripartite tricarboxylate transporter family receptor
RD03_RS19525	COG0753	catalase activity
RD03_RS19530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD03_RS19535	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
RD03_RS19545	COG2175	clavaminate synthase activity
RD03_RS19550	COG1473	amidohydrolase
RD03_RS19555	COG4608	Belongs to the ABC transporter superfamily
RD03_RS19560	COG0444	Belongs to the ABC transporter superfamily
RD03_RS19575	COG0747	negative chemotaxis
RD03_RS19580	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RD03_RS19615	COG0436	Aminotransferase
RD03_RS19620	COG1278	Cold shock