locus-tag	class	description
RD04_RS00005	COG0445	tRNA wobble uridine modification
RD04_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
RD04_RS00015	COG1192	Involved in chromosome partitioning
RD04_RS00025	COG1475	DNA binding
RD04_RS00030	COG0252	asparaginase activity
RD04_RS00055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RD04_RS00065	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RD04_RS00075	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RD04_RS00080	COG0081	regulation of translation
RD04_RS00085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RD04_RS00090	COG0222	ribosome binding
RD04_RS00095	COG0085	RNA polymerase activity
RD04_RS00100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RD04_RS00140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD04_RS00165	COG1024	Enoyl-CoA hydratase
RD04_RS00190	COG0752	glycyl-tRNA synthetase alpha subunit
RD04_RS00195	COG0751	glycine-tRNA ligase activity
RD04_RS00200	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RD04_RS00205	COG0204	Acyl-transferase
RD04_RS00220	COG0242	peptide deformylase activity
RD04_RS00255	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RD04_RS00260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RD04_RS00265	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RD04_RS00265	COG2813	Specifically methylates the guanine in position
RD04_RS00275	COG2223	nitrite transmembrane transporter activity
RD04_RS00285	COG1794	racemase activity, acting on amino acids and derivatives
RD04_RS00290	COG1126	abc transporter atp-binding protein
RD04_RS00295	COG0765	amino acid transport
RD04_RS00300	COG0765	amino acid transport
RD04_RS00305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD04_RS00365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD04_RS00395	COG0326	Molecular chaperone. Has ATPase activity
RD04_RS00400	COG0625	glutathione transferase activity
RD04_RS00415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RD04_RS00420	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RD04_RS00450	COG0438	transferase activity, transferring glycosyl groups
RD04_RS00455	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RD04_RS00460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RD04_RS00490	COG0859	PFAM glycosyl transferase family 9
RD04_RS00505	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
RD04_RS00515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RD04_RS00520	COG1127	ABC transporter
RD04_RS00545	COG1686	Belongs to the peptidase S11 family
RD04_RS00555	COG2921	Belongs to the UPF0250 family
RD04_RS00560	COG0321	lipoyl(octanoyl) transferase activity
RD04_RS00565	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RD04_RS00600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RD04_RS00610	COG0018	arginyl-trna synthetase
RD04_RS00630	COG0395	ABC-type sugar transport system, permease component
RD04_RS00635	COG1175	transmembrane transport
RD04_RS00640	COG1653	transport
RD04_RS00645	COG3842	ATPase activity
RD04_RS00650	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RD04_RS00660	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RD04_RS00680	COG1609	Transcriptional regulator
RD04_RS00690	COG0154	amidase activity
RD04_RS00695	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RD04_RS00705	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RD04_RS00715	COG0583	DNA-binding transcription factor activity
RD04_RS00730	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RD04_RS00735	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RD04_RS00750	COG1802	Transcriptional regulator
RD04_RS00765	COG1024	Enoyl-CoA hydratase
RD04_RS00780	COG3181	Tripartite tricarboxylate transporter family receptor
RD04_RS00795	COG1984	allophanate hydrolase subunit 2
RD04_RS00800	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RD04_RS00810	COG0583	DNA-binding transcription factor activity
RD04_RS00815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RD04_RS00825	COG5002	protein histidine kinase activity
RD04_RS00835	COG5002	protein histidine kinase activity
RD04_RS00840	COG0745	RESPONSE REGULATOR receiver
RD04_RS00845	COG2226	methyltransferase
RD04_RS00860	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RD04_RS00880	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
RD04_RS00890	COG0513	Belongs to the DEAD box helicase family
RD04_RS00895	COG1280	lysine exporter protein (LysE YggA)
RD04_RS00900	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
RD04_RS00935	COG1054	Belongs to the UPF0176 family
RD04_RS00940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RD04_RS00940	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RD04_RS00950	COG0489	protein tyrosine kinase activity
RD04_RS00965	COG0717	Belongs to the dCTP deaminase family
RD04_RS00995	COG2081	HI0933 family
RD04_RS01015	COG0668	transmembrane transport
RD04_RS01020	COG0165	Argininosuccinate lyase
RD04_RS01055	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RD04_RS01070	COG0667	Aldo Keto reductase
RD04_RS01080	COG5265	(ABC) transporter
RD04_RS01125	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RD04_RS01130	COG0439	Biotin carboxylase
RD04_RS01135	COG2188	Transcriptional regulator
RD04_RS01160	COG0511	ligase activity, forming carbon-carbon bonds
RD04_RS01190	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
RD04_RS01205	COG0500	methyltransferase
RD04_RS01210	COG5265	(ABC) transporter
RD04_RS01225	COG0028	Belongs to the TPP enzyme family
RD04_RS01230	COG0440	acetolactate synthase activity
RD04_RS01235	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RD04_RS01240	COG1183	phosphatidylcholine synthase activity
RD04_RS01250	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RD04_RS01255	COG1185	polyribonucleotide nucleotidyltransferase activity
RD04_RS01270	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RD04_RS01290	COG0149	triose-phosphate isomerase activity
RD04_RS01295	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RD04_RS01305	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RD04_RS01315	COG3799	methylaspartate ammonia-lyase activity
RD04_RS01355	COG0583	DNA-binding transcription factor activity
RD04_RS01360	COG0626	cystathionine gamma-synthase activity
RD04_RS01365	COG3608	succinylglutamate desuccinylase aspartoacylase
RD04_RS01385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD04_RS01405	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
RD04_RS01420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RD04_RS01425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RD04_RS01430	COG1733	regulation of RNA biosynthetic process
RD04_RS01440	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RD04_RS01445	COG0583	DNA-binding transcription factor activity
RD04_RS01450	COG1597	lipid kinase activity
RD04_RS01460	COG0671	phosphoesterase, PA-phosphatase related
RD04_RS01485	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RD04_RS01490	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RD04_RS01495	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RD04_RS01500	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RD04_RS01505	COG0649	NAD binding
RD04_RS01510	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
RD04_RS01520	COG1034	ATP synthesis coupled electron transport
RD04_RS01525	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
RD04_RS01530	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RD04_RS01540	COG0713	ATP synthesis coupled electron transport
RD04_RS01555	COG1007	ATP synthesis coupled electron transport
RD04_RS01565	COG4774	siderophore transport
RD04_RS01570	COG4774	siderophore transport
RD04_RS01585	COG0028	Belongs to the TPP enzyme family
RD04_RS01590	COG3181	Tripartite tricarboxylate transporter family receptor
RD04_RS01595	COG0583	DNA-binding transcription factor activity
RD04_RS01600	COG0560	Phosphoserine phosphatase
RD04_RS01605	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RD04_RS01610	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RD04_RS01615	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RD04_RS01625	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
RD04_RS01630	COG0308	aminopeptidase N
RD04_RS01650	COG0028	Belongs to the TPP enzyme family
RD04_RS01670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD04_RS01680	COG0318	PFAM AMP-dependent synthetase and ligase
RD04_RS01690	COG1802	Transcriptional regulator
RD04_RS01700	COG1802	Transcriptional regulator
RD04_RS01710	COG1028	Short-chain dehydrogenase reductase Sdr
RD04_RS01730	COG1126	abc transporter atp-binding protein
RD04_RS01735	COG0765	amino acid transport
RD04_RS01755	COG1538	Outer membrane efflux protein
RD04_RS01760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RD04_RS01765	COG2274	protein secretion by the type I secretion system
RD04_RS01770	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
RD04_RS01780	COG2994	toxin metabolic process
RD04_RS01795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD04_RS01800	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
RD04_RS01810	COG0583	DNA-binding transcription factor activity
RD04_RS01820	COG0142	geranyltranstransferase activity
RD04_RS01830	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RD04_RS01835	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RD04_RS01840	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RD04_RS01845	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RD04_RS01885	COG3712	iron ion homeostasis
RD04_RS01890	COG4774	siderophore transport
RD04_RS01895	COG2353	YceI-like domain
RD04_RS01915	COG0019	diaminopimelate decarboxylase activity
RD04_RS01935	COG0747	negative chemotaxis
RD04_RS01940	COG0601	transmembrane transport
RD04_RS01945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD04_RS01955	COG0154	amidase activity
RD04_RS01960	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RD04_RS01985	COG2154	pterin-4-alpha-carbinolamine dehydratase
RD04_RS01995	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RD04_RS02005	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RD04_RS02010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RD04_RS02015	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RD04_RS02020	COG1929	Belongs to the glycerate kinase type-1 family
RD04_RS02025	COG0469	pyruvate kinase activity
RD04_RS02030	COG0700	Nucleoside recognition
RD04_RS02060	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
RD04_RS02065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RD04_RS02080	COG0823	Involved in the tonB-independent uptake of proteins
RD04_RS02090	COG0848	biopolymer transport protein
RD04_RS02095	COG0811	peptide transport
RD04_RS02100	COG0824	Thioesterase
RD04_RS02105	COG0442	prolyl-tRNA aminoacylation
RD04_RS02110	COG0494	nUDIX hydrolase
RD04_RS02125	COG2135	peptidase activity
RD04_RS02190	COG1196	nuclear chromosome segregation
RD04_RS02335	COG1464	Belongs to the NlpA lipoprotein family
RD04_RS02365	COG4211	Belongs to the binding-protein-dependent transport system permease family
RD04_RS02375	COG0154	amidase activity
RD04_RS02380	COG0288	reversible hydration of carbon dioxide
RD04_RS02395	COG0514	ATP-dependent DNA helicase (RecQ)
RD04_RS02400	COG2255	four-way junction helicase activity
RD04_RS02415	COG0632	four-way junction helicase activity
RD04_RS02420	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RD04_RS02450	COG0006	proline dipeptidase activity
RD04_RS02475	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RD04_RS02490	COG4783	chaperone-mediated protein folding
RD04_RS02495	COG0429	hydrolase of the alpha beta-hydrolase fold
RD04_RS02525	COG0513	Belongs to the DEAD box helicase family
RD04_RS02545	COG1546	Belongs to the CinA family
RD04_RS02545	COG1058	Belongs to the CinA family
RD04_RS02550	COG1414	Transcriptional regulator
RD04_RS02570	COG0167	dihydroorotate dehydrogenase activity
RD04_RS02575	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
RD04_RS02580	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
RD04_RS02590	COG0583	DNA-binding transcription factor activity
RD04_RS02650	COG0280	phosphate acetyltransferase
RD04_RS02650	COG0281	malic enzyme
RD04_RS02660	COG0601	transmembrane transport
RD04_RS02665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD04_RS02670	COG4172	Belongs to the ABC transporter superfamily
RD04_RS02700	COG0640	Transcriptional regulator
RD04_RS02715	COG3135	benzoate transporter
RD04_RS02720	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RD04_RS02725	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RD04_RS02730	COG0742	ribosomal rna small subunit methyltransferase
RD04_RS02750	COG3639	organic phosphonate transmembrane transporter activity
RD04_RS02755	COG3639	organic phosphonate transmembrane transporter activity
RD04_RS02760	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RD04_RS02795	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RD04_RS02800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RD04_RS02810	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RD04_RS02815	COG1546	Belongs to the CinA family
RD04_RS02815	COG1058	Belongs to the CinA family
RD04_RS02820	COG0284	orotidine-5'-phosphate decarboxylase activity
RD04_RS02825	COG1252	NADH dehydrogenase
RD04_RS02840	COG3468	outer membrane autotransporter barrel domain protein
RD04_RS02845	COG0459	protein refolding
RD04_RS02850	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RD04_RS02870	COG1053	succinate dehydrogenase
RD04_RS02880	COG0583	DNA-binding transcription factor activity
RD04_RS02885	COG1053	succinate dehydrogenase
RD04_RS02900	COG3706	GGDEF domain
RD04_RS02935	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RD04_RS02940	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
RD04_RS02950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RD04_RS02960	COG0069	glutamate synthase activity
RD04_RS02965	COG2391	methyltransferase activity
RD04_RS02970	COG0679	Auxin Efflux Carrier
RD04_RS02995	COG0557	exoribonuclease II activity
RD04_RS03000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RD04_RS03010	COG3128	pkhd-type hydroxylase
RD04_RS03015	COG0776	regulation of translation
RD04_RS03045	COG0642	Histidine kinase
RD04_RS03050	COG3158	transport of potassium into the cell
RD04_RS03055	COG0137	argininosuccinate synthase activity
RD04_RS03060	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RD04_RS03065	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RD04_RS03075	COG0583	DNA-binding transcription factor activity
RD04_RS03085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RD04_RS03105	COG2186	Transcriptional regulator
RD04_RS03115	COG2223	nitrite transmembrane transporter activity
RD04_RS03125	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RD04_RS03130	COG0450	alkyl hydroperoxide reductase
RD04_RS03150	COG1214	PFAM Peptidase M22, glycoprotease
RD04_RS03155	COG1573	uracil-dna glycosylase
RD04_RS03160	COG0477	Major facilitator Superfamily
RD04_RS03165	COG1196	nuclear chromosome segregation
RD04_RS03175	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RD04_RS03180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RD04_RS03195	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RD04_RS03200	COG1122	ATPase activity
RD04_RS03205	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
RD04_RS03210	COG1268	BioY protein
RD04_RS03230	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RD04_RS03265	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RD04_RS03270	COG2878	Part of a membrane complex involved in electron transport
RD04_RS03285	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RD04_RS03290	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
RD04_RS03295	COG0251	oxidation-reduction process
RD04_RS03305	COG3228	Belongs to the MtfA family
RD04_RS03310	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RD04_RS03320	COG0133	tryptophan synthase activity
RD04_RS03325	COG0159	tryptophan synthase activity
RD04_RS03330	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RD04_RS03335	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
RD04_RS03350	COG1530	ribonuclease E activity
RD04_RS03360	COG0546	phosphoglycolate phosphatase activity
RD04_RS03365	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RD04_RS03370	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
RD04_RS03385	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD04_RS03390	COG0583	DNA-binding transcription factor activity
RD04_RS03400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD04_RS03425	COG0251	oxidation-reduction process
RD04_RS03430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RD04_RS03430	COG1017	nitric oxide dioxygenase activity
RD04_RS03435	COG2031	fatty acid transporter
RD04_RS03440	COG1012	belongs to the aldehyde dehydrogenase family
RD04_RS03445	COG1802	Transcriptional regulator
RD04_RS03455	COG1278	Cold shock
RD04_RS03460	COG0583	DNA-binding transcription factor activity
RD04_RS03480	COG0183	Belongs to the thiolase family
RD04_RS03490	COG1960	acyl-CoA dehydrogenase activity
RD04_RS03495	COG0583	DNA-binding transcription factor activity
RD04_RS03500	COG3181	Tripartite tricarboxylate transporter family receptor
RD04_RS03505	COG1024	Enoyl-CoA hydratase
RD04_RS03510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD04_RS03515	COG1253	flavin adenine dinucleotide binding
RD04_RS03520	COG1285	pathogenesis
RD04_RS03530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RD04_RS03545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RD04_RS03555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RD04_RS03560	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RD04_RS03575	COG2031	fatty acid transporter
RD04_RS03585	COG0786	glutamate:sodium symporter activity
RD04_RS03600	COG0463	Glycosyl transferase, family 2
RD04_RS03605	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RD04_RS03630	COG0697	spore germination
RD04_RS03640	COG3181	Tripartite tricarboxylate transporter family receptor
RD04_RS03665	COG0028	Belongs to the TPP enzyme family
RD04_RS03670	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD04_RS03675	COG1024	Enoyl-CoA hydratase
RD04_RS03675	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD04_RS03680	COG3181	Tripartite tricarboxylate transporter family receptor
RD04_RS03690	COG0492	ferredoxin-NADP+ reductase activity
RD04_RS03715	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD04_RS03725	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD04_RS03745	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RD04_RS03760	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
RD04_RS03765	COG2823	Periplasmic or secreted lipoprotein
RD04_RS03780	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RD04_RS03790	COG1309	transcriptional regulator
RD04_RS03795	COG0471	metal ion transport
RD04_RS03800	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RD04_RS03805	COG0772	Belongs to the SEDS family
RD04_RS03810	COG0768	penicillin binding
RD04_RS03820	COG1792	Involved in formation and maintenance of cell shape
RD04_RS03825	COG1077	Cell shape determining protein MreB Mrl
RD04_RS03830	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RD04_RS03835	COG0154	amidase activity
RD04_RS03840	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RD04_RS03845	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RD04_RS03850	COG0708	Exodeoxyribonuclease III
RD04_RS03855	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RD04_RS03860	COG2860	membrane
RD04_RS03895	COG1012	belongs to the aldehyde dehydrogenase family
RD04_RS03905	COG3069	C4-dicarboxylate transmembrane transporter activity
RD04_RS03915	COG1802	Transcriptional regulator
RD04_RS03950	COG1595	DNA-templated transcription, initiation
RD04_RS03955	COG3712	iron ion homeostasis
RD04_RS03965	COG3720	iron ion transport
RD04_RS03970	COG4558	Periplasmic binding protein
RD04_RS03975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RD04_RS03980	COG1120	ATPase activity
RD04_RS03985	COG1683	Conserved Protein
RD04_RS04035	COG1234	tRNA 3'-trailer cleavage
RD04_RS04070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RD04_RS04080	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RD04_RS04095	COG0540	Belongs to the ATCase OTCase family
RD04_RS04100	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RD04_RS04105	COG1678	Uncharacterized ACR, COG1678
RD04_RS04120	COG0352	thiamine-phosphate diphosphorylase activity
RD04_RS04125	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RD04_RS04150	COG1960	acyl-CoA dehydrogenase activity
RD04_RS04155	COG1024	Enoyl-CoA hydratase
RD04_RS04225	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
RD04_RS04235	COG0583	DNA-binding transcription factor activity
RD04_RS04240	COG2814	Major facilitator Superfamily
RD04_RS04245	COG0129	dihydroxy-acid dehydratase activity
RD04_RS04250	COG2207	Transcriptional regulator
RD04_RS04255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RD04_RS04265	COG0657	acetylesterase activity
RD04_RS04270	COG0747	negative chemotaxis
RD04_RS04275	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RD04_RS04280	COG2808	Putative FMN-binding domain
RD04_RS04295	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RD04_RS04300	COG1970	mechanosensitive ion channel activity
RD04_RS04305	COG0723	plastoquinol--plastocyanin reductase activity
RD04_RS04310	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RD04_RS04320	COG2857	Cytochrome c1
RD04_RS04325	COG0625	glutathione transferase activity
RD04_RS04330	COG2969	positive regulation of protein catabolic process
RD04_RS04355	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RD04_RS04370	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RD04_RS04380	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
RD04_RS04385	COG4988	ABC transporter
RD04_RS04395	COG1294	oxidase, subunit
RD04_RS04420	COG1960	acyl-CoA dehydrogenase activity
RD04_RS04430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD04_RS04445	COG3181	Tripartite tricarboxylate transporter family receptor
RD04_RS04455	COG0114	fumarate hydratase activity
RD04_RS04460	COG0802	atpase or kinase
RD04_RS04465	COG0860	N-Acetylmuramoyl-L-alanine amidase
RD04_RS04470	COG0586	Pfam SNARE associated Golgi protein
RD04_RS04475	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RD04_RS04480	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RD04_RS04485	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RD04_RS04500	COG0617	tRNA 3'-terminal CCA addition
RD04_RS04525	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD04_RS04530	COG2188	Transcriptional regulator
RD04_RS04540	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RD04_RS04550	COG1028	Short-chain dehydrogenase reductase Sdr
RD04_RS04575	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RD04_RS04580	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
RD04_RS04585	COG1012	belongs to the aldehyde dehydrogenase family
RD04_RS04605	COG4257	antibiotic catabolic process
RD04_RS04615	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
RD04_RS04620	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
RD04_RS04630	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD04_RS04635	COG2031	fatty acid transporter
RD04_RS04640	COG1028	Short-chain dehydrogenase reductase Sdr
RD04_RS04645	COG1414	Transcriptional regulator
RD04_RS04655	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RD04_RS04670	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RD04_RS04710	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RD04_RS04710	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RD04_RS04715	COG0509	glycine decarboxylation via glycine cleavage system
RD04_RS04720	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RD04_RS04730	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RD04_RS04770	COG0747	negative chemotaxis
RD04_RS04775	COG0601	transmembrane transport
RD04_RS04780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD04_RS04785	COG1162	GTPase activity
RD04_RS04790	COG0501	Belongs to the peptidase M48B family
RD04_RS04795	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
RD04_RS04805	COG3327	negative regulation of DNA-templated transcription, initiation
RD04_RS04810	COG3396	Phenylacetate-CoA oxygenase
RD04_RS04815	COG3460	Phenylacetate-CoA oxygenase
RD04_RS04820	COG3396	Phenylacetate-CoA oxygenase
RD04_RS04825	COG2151	metal-sulfur cluster biosynthetic enzyme
RD04_RS04830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RD04_RS04840	COG1012	belongs to the aldehyde dehydrogenase family
RD04_RS04845	COG1024	Enoyl-CoA hydratase
RD04_RS04850	COG2050	protein possibly involved in aromatic compounds catabolism
RD04_RS04860	COG3539	Fimbrial protein
RD04_RS04875	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD04_RS04880	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD04_RS04880	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD04_RS04885	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD04_RS04890	COG0047	phosphoribosylformylglycinamidine synthase activity
RD04_RS04890	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RD04_RS04920	COG0235	Class ii aldolase
RD04_RS04925	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD04_RS04930	COG0720	synthase
RD04_RS04935	COG0602	queuosine metabolic process
RD04_RS04960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RD04_RS04995	COG3181	Tripartite tricarboxylate transporter family receptor
RD04_RS05025	COG3842	ATPase activity
RD04_RS05035	COG0395	ABC-type sugar transport system, permease component
RD04_RS05065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD04_RS05070	COG0420	3'-5' exonuclease activity
RD04_RS05095	COG2197	response regulator
RD04_RS05120	COG0519	Catalyzes the synthesis of GMP from XMP
RD04_RS05120	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RD04_RS05130	COG3550	peptidyl-serine autophosphorylation
RD04_RS05140	COG0477	Major facilitator Superfamily
RD04_RS05155	COG1228	amidohydrolase
RD04_RS05165	COG1116	anion transmembrane transporter activity
RD04_RS05170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD04_RS05195	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
RD04_RS05210	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
RD04_RS05240	COG2814	Major facilitator Superfamily
RD04_RS05255	COG1280	lysine exporter protein (LysE YggA)
RD04_RS05275	COG0747	negative chemotaxis
RD04_RS05280	COG0601	transmembrane transport
RD04_RS05285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD04_RS05290	COG4172	Belongs to the ABC transporter superfamily
RD04_RS05295	COG1609	Transcriptional regulator
RD04_RS05320	COG0586	Pfam SNARE associated Golgi protein
RD04_RS05330	COG0500	methyltransferase
RD04_RS05345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RD04_RS05355	COG0756	dUTP diphosphatase activity
RD04_RS05365	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RD04_RS05370	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RD04_RS05375	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RD04_RS05380	COG0072	phenylalanine-tRNA ligase activity
RD04_RS05380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RD04_RS05385	COG0776	regulation of translation
RD04_RS05455	COG0540	Belongs to the ATCase OTCase family
RD04_RS05460	COG2974	May be involved in recombination
RD04_RS05470	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD04_RS05475	COG0583	DNA-binding transcription factor activity
RD04_RS05495	COG1028	Short-chain dehydrogenase reductase Sdr
RD04_RS05510	COG3842	ATPase activity
RD04_RS05515	COG1024	Enoyl-CoA hydratase
RD04_RS05515	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD04_RS05535	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RD04_RS05540	COG2137	regulation of response to DNA damage stimulus
RD04_RS05550	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
RD04_RS05560	COG0045	succinate-CoA ligase (ADP-forming) activity
RD04_RS05565	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RD04_RS05570	COG0861	Integral membrane protein TerC family
RD04_RS05575	COG0861	Integral membrane protein TerC family
RD04_RS05580	COG0181	hydroxymethylbilane synthase activity
RD04_RS05640	COG4964	Belongs to the GSP D family
RD04_RS05670	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RD04_RS05680	COG0583	DNA-binding transcription factor activity
RD04_RS05690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD04_RS05695	COG4311	Sarcosine oxidase, delta subunit
RD04_RS05700	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RD04_RS05700	COG0446	pyridine nucleotide-disulphide oxidoreductase
RD04_RS05735	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RD04_RS05740	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RD04_RS05745	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RD04_RS05750	COG0735	belongs to the Fur family
RD04_RS05755	COG0497	DNA recombination
RD04_RS05760	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RD04_RS05765	COG1420	regulation of RNA biosynthetic process
RD04_RS05770	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RD04_RS05780	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RD04_RS05790	COG0443	Heat shock 70 kDa protein
RD04_RS05800	COG0612	Peptidase, M16
RD04_RS05820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RD04_RS05865	COG0745	RESPONSE REGULATOR receiver
RD04_RS05870	COG2205	protein histidine kinase activity
RD04_RS05875	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
RD04_RS05880	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
RD04_RS05885	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
RD04_RS05895	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RD04_RS05915	COG0492	ferredoxin-NADP+ reductase activity
RD04_RS05920	COG1674	ftsk spoiiie
RD04_RS05925	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
RD04_RS05930	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RD04_RS05935	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RD04_RS05960	COG3706	GGDEF domain
RD04_RS05980	COG2814	Major facilitator Superfamily
RD04_RS06010	COG3486	L-lysine 6-monooxygenase (NADPH) activity
RD04_RS06025	COG1028	Short-chain dehydrogenase reductase Sdr
RD04_RS06035	COG3022	response to hydroperoxide
RD04_RS06045	COG1289	transmembrane transporter activity
RD04_RS06065	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RD04_RS06075	COG2197	response regulator
RD04_RS06080	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RD04_RS06085	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RD04_RS06090	COG0189	ligase activity
RD04_RS06100	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RD04_RS06105	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RD04_RS06115	COG2423	ornithine cyclodeaminase activity
RD04_RS06125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD04_RS06130	COG0765	amino acid transport
RD04_RS06135	COG0765	amino acid transport
RD04_RS06140	COG1126	abc transporter atp-binding protein
RD04_RS06195	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RD04_RS06205	COG2944	sequence-specific DNA binding
RD04_RS06210	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
RD04_RS06215	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RD04_RS06220	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RD04_RS06225	COG0009	L-threonylcarbamoyladenylate synthase
RD04_RS06230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD04_RS06235	COG1414	Transcriptional regulator
RD04_RS06250	COG0765	amino acid transport
RD04_RS06255	COG1126	abc transporter atp-binding protein
RD04_RS06260	COG0028	Belongs to the TPP enzyme family
RD04_RS06275	COG0028	Belongs to the TPP enzyme family
RD04_RS06280	COG0583	DNA-binding transcription factor activity
RD04_RS06285	COG4974	Belongs to the 'phage' integrase family
RD04_RS06290	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RD04_RS06295	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
RD04_RS06310	COG1686	Belongs to the peptidase S11 family
RD04_RS06320	COG2814	Major facilitator Superfamily
RD04_RS06330	COG1074	ATP-dependent DNA helicase activity
RD04_RS06340	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RD04_RS06345	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RD04_RS06350	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RD04_RS06370	COG2321	neutral zinc metallopeptidase
RD04_RS06375	COG0009	L-threonylcarbamoyladenylate synthase
RD04_RS06415	COG3360	Dodecin
RD04_RS06420	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RD04_RS06425	COG2850	peptidyl-arginine hydroxylation
RD04_RS06435	COG3539	Fimbrial protein
RD04_RS06440	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
RD04_RS06445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RD04_RS06450	COG1994	Peptidase M50
RD04_RS06460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD04_RS06465	COG0765	amino acid transport
RD04_RS06470	COG1126	abc transporter atp-binding protein
RD04_RS06475	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RD04_RS06480	COG1758	RNA polymerase activity
RD04_RS06485	COG0194	GDP metabolic process
RD04_RS06490	COG3258	Cytochrome c
RD04_RS06495	COG2863	cytochrome
RD04_RS06500	COG1028	Short-chain dehydrogenase reductase Sdr
RD04_RS06505	COG0791	NLP P60 protein
RD04_RS06510	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RD04_RS06530	COG1561	YicC-like family, N-terminal region
RD04_RS06535	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RD04_RS06550	COG2200	EAL domain
RD04_RS06550	COG2199	diguanylate cyclase activity
RD04_RS06555	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RD04_RS06565	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RD04_RS06570	COG0174	glutamine synthetase
RD04_RS06580	COG2204	response regulator
RD04_RS06585	COG0583	DNA-binding transcription factor activity
RD04_RS06590	COG1741	Belongs to the pirin family
RD04_RS06595	COG1741	Belongs to the pirin family
RD04_RS06605	COG3842	ATPase activity
RD04_RS06610	COG1178	ABC-type Fe3 transport system permease component
RD04_RS06615	COG1840	ABC-type Fe3 transport system, periplasmic component
RD04_RS06625	COG0583	DNA-binding transcription factor activity
RD04_RS06635	COG0656	L-ascorbic acid biosynthetic process
RD04_RS06650	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RD04_RS06655	COG0583	DNA-binding transcription factor activity
RD04_RS06670	COG0783	Belongs to the Dps family
RD04_RS06705	COG0438	transferase activity, transferring glycosyl groups
RD04_RS06720	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
RD04_RS06745	COG0300	oxidoreductase activity
RD04_RS06790	COG0861	Integral membrane protein TerC family
RD04_RS06795	COG1028	Short-chain dehydrogenase reductase Sdr
RD04_RS06815	COG0714	Associated with various cellular activities
RD04_RS06845	COG3119	arylsulfatase activity
RD04_RS06870	COG2197	response regulator
RD04_RS06880	COG2944	sequence-specific DNA binding
RD04_RS06885	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
RD04_RS06890	COG0625	glutathione transferase activity
RD04_RS06920	COG0179	Fumarylacetoacetate (FAA) hydrolase
RD04_RS06925	COG1028	Short-chain dehydrogenase reductase Sdr
RD04_RS06970	COG0431	NADPH-dependent FMN reductase
RD04_RS07000	COG1028	Short-chain dehydrogenase reductase Sdr
RD04_RS07005	COG0583	DNA-binding transcription factor activity
RD04_RS07020	COG3181	Tripartite tricarboxylate transporter family receptor
RD04_RS07025	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RD04_RS07025	COG2111	Na H antiporter
RD04_RS07030	COG1006	Multisubunit Na H antiporter MnhC subunit
RD04_RS07035	COG0651	ATP synthesis coupled electron transport
RD04_RS07040	COG1863	multisubunit Na H antiporter MnhE subunit
RD04_RS07045	COG2212	antiporter activity
RD04_RS07070	COG0590	tRNA wobble adenosine to inosine editing
RD04_RS07075	COG1619	proteins homologs of microcin C7 resistance protein MccF
RD04_RS07080	COG1024	Enoyl-CoA hydratase
RD04_RS07095	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD04_RS07100	COG0488	(ABC) transporter
RD04_RS07135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RD04_RS07145	COG2252	PERMEase
RD04_RS07150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RD04_RS07160	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RD04_RS07165	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
RD04_RS07195	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RD04_RS07200	COG0789	Transcriptional regulator
RD04_RS07210	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RD04_RS07210	COG0678	peroxiredoxin activity
RD04_RS07220	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
RD04_RS07225	COG0584	glycerophosphoryl diester phosphodiesterase
RD04_RS07230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RD04_RS07240	COG4181	ATPase activity
RD04_RS07250	COG2823	Periplasmic or secreted lipoprotein
RD04_RS07260	COG3237	CsbD-like
RD04_RS07265	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RD04_RS07265	COG1181	Belongs to the D-alanine--D-alanine ligase family
RD04_RS07270	COG0189	ligase activity
RD04_RS07270	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RD04_RS07290	COG2833	Protein of unknown function (DUF455)
RD04_RS07295	COG2951	lytic endotransglycosylase activity
RD04_RS07310	COG1522	sequence-specific DNA binding
RD04_RS07320	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RD04_RS07325	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RD04_RS07330	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RD04_RS07335	COG0196	riboflavin kinase activity
RD04_RS07340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RD04_RS07340	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RD04_RS07360	COG0210	DNA helicase
RD04_RS07365	COG4771	TonB-dependent receptor
RD04_RS07370	COG0488	(ABC) transporter
RD04_RS07375	COG2890	protein-(glutamine-N5) methyltransferase activity
RD04_RS07380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RD04_RS07385	COG2171	N-acyltransferase activity
RD04_RS07420	COG1278	Cold shock
RD04_RS07430	COG1278	Cold shock
RD04_RS07440	COG0544	peptidyl-prolyl cis-trans isomerase activity
RD04_RS07445	COG0740	serine-type endopeptidase activity
RD04_RS07450	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RD04_RS07455	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RD04_RS07460	COG0583	DNA-binding transcription factor activity
RD04_RS07465	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD04_RS07480	COG1024	Enoyl-CoA hydratase
RD04_RS07490	COG0183	Belongs to the thiolase family
RD04_RS07495	COG1028	Short-chain dehydrogenase reductase Sdr
RD04_RS07500	COG1960	acyl-CoA dehydrogenase activity
RD04_RS07515	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RD04_RS07540	COG3468	outer membrane autotransporter barrel domain protein
RD04_RS07545	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RD04_RS07555	COG0556	nucleotide-excision repair
RD04_RS07560	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RD04_RS07570	COG1104	cysteine desulfurase activity
RD04_RS07575	COG0822	iron-sulfur transferase activity
RD04_RS07580	COG0316	Belongs to the HesB IscA family
RD04_RS07585	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RD04_RS07590	COG0443	Heat shock 70 kDa protein
RD04_RS07595	COG0633	Ferredoxin
RD04_RS07615	COG1024	Enoyl-CoA hydratase
RD04_RS07635	COG3395	kinase activity
RD04_RS07640	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RD04_RS07655	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
RD04_RS07665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD04_RS07690	COG0747	negative chemotaxis
RD04_RS07695	COG0601	transmembrane transport
RD04_RS07700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD04_RS07705	COG4172	Belongs to the ABC transporter superfamily
RD04_RS07710	COG0154	amidase activity
RD04_RS07755	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RD04_RS07760	COG0425	Belongs to the sulfur carrier protein TusA family
RD04_RS07770	COG0228	four-way junction DNA binding
RD04_RS07775	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RD04_RS07780	COG0336	Belongs to the RNA methyltransferase TrmD family
RD04_RS07785	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RD04_RS07800	COG0642	Histidine kinase
RD04_RS07815	COG0525	valine-tRNA ligase activity
RD04_RS07820	COG0105	UTP biosynthetic process
RD04_RS07825	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RD04_RS07835	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RD04_RS07840	COG0124	histidyl-tRNA synthetase
RD04_RS07845	COG2976	Protein conserved in bacteria
RD04_RS07850	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RD04_RS07855	COG1160	GTP binding
RD04_RS07860	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RD04_RS07865	COG1923	regulation of RNA biosynthetic process
RD04_RS07870	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RD04_RS07875	COG0330	HflC and HflK could
RD04_RS07880	COG0330	HflC and HflK could
RD04_RS07885	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
RD04_RS07890	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RD04_RS07895	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
RD04_RS07900	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RD04_RS07910	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RD04_RS07935	COG0628	permease
RD04_RS07940	COG0842	Transport permease protein
RD04_RS07945	COG1131	(ABC) transporter
RD04_RS08015	COG0156	8-amino-7-oxononanoate synthase activity
RD04_RS08025	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RD04_RS08025	COG4106	trans-aconitate 2-methyltransferase activity
RD04_RS08030	COG1380	Effector of murein hydrolase LrgA
RD04_RS08035	COG1346	cytolysis
RD04_RS08045	COG3284	Transcriptional regulator
RD04_RS08050	COG1012	belongs to the aldehyde dehydrogenase family
RD04_RS08065	COG2733	membrane
RD04_RS08070	COG0583	DNA-binding transcription factor activity
RD04_RS08075	COG0384	phenazine biosynthesis protein PhzF
RD04_RS08080	COG5507	3-demethylubiquinone-9 3-methyltransferase
RD04_RS08085	COG2169	Transcriptional regulator
RD04_RS08115	COG0659	secondary active sulfate transmembrane transporter activity
RD04_RS08140	COG1132	(ABC) transporter
RD04_RS08185	COG2207	Transcriptional regulator
RD04_RS08315	COG2346	COG2346, Truncated hemoglobins
RD04_RS08340	COG0583	DNA-binding transcription factor activity
RD04_RS08345	COG4692	amylo-alpha-1,6-glucosidase activity
RD04_RS08355	COG0183	Belongs to the thiolase family
RD04_RS08370	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD04_RS08375	COG0633	Ferredoxin
RD04_RS08385	COG1024	Enoyl-CoA hydratase
RD04_RS08395	COG4638	Rieske (2fe-2S)
RD04_RS08405	COG0559	Belongs to the binding-protein-dependent transport system permease family
RD04_RS08425	COG2224	Isocitrate lyase
RD04_RS08430	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RD04_RS08430	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RD04_RS08445	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RD04_RS08450	COG0322	excinuclease ABC activity
RD04_RS08455	COG1472	Belongs to the glycosyl hydrolase 3 family
RD04_RS08460	COG0736	holo-[acyl-carrier-protein] synthase activity
RD04_RS08465	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
RD04_RS08475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RD04_RS08480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RD04_RS08505	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RD04_RS08520	COG2032	superoxide dismutase activity
RD04_RS08535	COG1024	Enoyl-CoA hydratase
RD04_RS08545	COG1802	Transcriptional regulator
RD04_RS08555	COG0183	Belongs to the thiolase family
RD04_RS08560	COG1942	4-Oxalocrotonate Tautomerase
RD04_RS08570	COG4176	ABC-type proline glycine betaine transport system permease component
RD04_RS08585	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RD04_RS08590	COG2814	Major facilitator Superfamily
RD04_RS08595	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RD04_RS08600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RD04_RS08625	COG2814	Major facilitator Superfamily
RD04_RS08630	COG0495	leucyl-tRNA aminoacylation
RD04_RS08645	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RD04_RS08655	COG0154	amidase activity
RD04_RS08660	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD04_RS08715	COG0427	acetyl-CoA hydrolase
RD04_RS08720	COG0583	DNA-binding transcription factor activity
RD04_RS08735	COG0730	response to heat
RD04_RS08740	COG0697	spore germination
RD04_RS08775	COG2885	chlorophyll binding
RD04_RS08800	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RD04_RS08805	COG3384	dioxygenase
RD04_RS08820	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RD04_RS08825	COG3474	cytochrome
RD04_RS08835	COG1595	DNA-templated transcription, initiation
RD04_RS08850	COG2204	response regulator
RD04_RS08890	COG4964	Belongs to the GSP D family
RD04_RS08940	COG1846	Transcriptional regulator
RD04_RS08945	COG4172	Belongs to the ABC transporter superfamily
RD04_RS08950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD04_RS08955	COG0601	transmembrane transport
RD04_RS08960	COG0747	negative chemotaxis
RD04_RS08970	COG0598	Magnesium transport protein CorA
RD04_RS08975	COG0210	DNA helicase
RD04_RS08990	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RD04_RS08995	COG1012	belongs to the aldehyde dehydrogenase family
RD04_RS09000	COG0483	inositol monophosphate 1-phosphatase activity
RD04_RS09005	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RD04_RS09015	COG1045	serine acetyltransferase
RD04_RS09020	COG0166	Belongs to the GPI family
RD04_RS09045	COG3181	Tripartite tricarboxylate transporter family receptor
RD04_RS09060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RD04_RS09060	COG1017	nitric oxide dioxygenase activity
RD04_RS09075	COG1335	isochorismatase
RD04_RS09080	COG2309	aminopeptidase activity
RD04_RS09085	COG0596	Alpha beta hydrolase
RD04_RS09090	COG3473	Maleate cis-trans isomerase
RD04_RS09095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RD04_RS09100	COG2080	2 iron, 2 sulfur cluster binding
RD04_RS09105	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RD04_RS09105	COG2010	Cytochrome c
RD04_RS09135	COG1846	Transcriptional regulator
RD04_RS09155	COG0726	polysaccharide deacetylase
RD04_RS09155	COG1649	PFAM Uncharacterised BCR, COG1649
RD04_RS09160	COG1215	transferase activity, transferring glycosyl groups
RD04_RS09170	COG1902	pentaerythritol trinitrate reductase activity
RD04_RS09195	COG0251	oxidation-reduction process
RD04_RS09205	COG1832	CoA-binding protein
RD04_RS09210	COG1414	Transcriptional regulator
RD04_RS09215	COG1902	pentaerythritol trinitrate reductase activity
RD04_RS09215	COG0446	pyridine nucleotide-disulphide oxidoreductase
RD04_RS09225	COG3842	ATPase activity
RD04_RS09255	COG0583	DNA-binding transcription factor activity
RD04_RS09265	COG1028	Short-chain dehydrogenase reductase Sdr
RD04_RS09270	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
RD04_RS09275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RD04_RS09290	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD04_RS09290	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD04_RS09295	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD04_RS09320	COG0527	aspartate kinase activity
RD04_RS09325	COG0037	tRNA processing
RD04_RS09335	COG0825	malonyl-CoA metabolic process
RD04_RS09345	COG0215	cysteine-tRNA ligase activity
RD04_RS09360	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RD04_RS09365	COG1968	undecaprenyl-diphosphatase activity
RD04_RS09370	COG1253	flavin adenine dinucleotide binding
RD04_RS09375	COG0483	inositol monophosphate 1-phosphatase activity
RD04_RS09395	COG0668	transmembrane transport
RD04_RS09420	COG0583	DNA-binding transcription factor activity
RD04_RS09445	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD04_RS09460	COG2831	hemolysin activation secretion protein
RD04_RS09465	COG3539	Fimbrial protein
RD04_RS09470	COG3188	usher protein
RD04_RS09475	COG3121	Chaperone
RD04_RS09485	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
RD04_RS09485	COG3064	Membrane
RD04_RS09485	COG3210	domain, Protein
RD04_RS09490	COG2197	response regulator
RD04_RS09495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD04_RS09495	COG2205	protein histidine kinase activity
RD04_RS09505	COG4336	lyase activity
RD04_RS09530	COG3189	MarR family transcriptional regulator
RD04_RS09545	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD04_RS09555	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD04_RS09555	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD04_RS09565	COG0028	Belongs to the TPP enzyme family
RD04_RS09575	COG1012	belongs to the aldehyde dehydrogenase family
RD04_RS09580	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RD04_RS09585	COG0010	Belongs to the arginase family
RD04_RS09590	COG1126	abc transporter atp-binding protein
RD04_RS09600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD04_RS09615	COG0084	hydrolase, TatD family'
RD04_RS09620	COG0084	hydrolase, TatD family'
RD04_RS09625	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RD04_RS09630	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RD04_RS09635	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RD04_RS09655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD04_RS09660	COG1959	2 iron, 2 sulfur cluster binding
RD04_RS09665	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RD04_RS09665	COG1017	nitric oxide dioxygenase activity
RD04_RS09695	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RD04_RS09700	COG2358	TRAP transporter, solute receptor (TAXI family
RD04_RS09730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RD04_RS09735	COG1366	Belongs to the anti-sigma-factor antagonist family
RD04_RS09740	COG2172	sigma factor antagonist activity
RD04_RS09745	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RD04_RS09755	COG2208	phosphoserine phosphatase activity
RD04_RS09755	COG2770	Histidine kinase
RD04_RS09780	COG1595	DNA-templated transcription, initiation
RD04_RS09795	COG4792	protein secretion
RD04_RS09800	COG4791	protein targeting
RD04_RS09805	COG4794	Type iii secretion
RD04_RS09810	COG4790	Type iii secretion
RD04_RS09845	COG4669	(LipO)protein
RD04_RS09910	COG4789	Type iii secretion
RD04_RS09940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RD04_RS09945	COG0840	transmembrane signaling receptor activity
RD04_RS09950	COG2233	PERMEase
RD04_RS09970	COG0492	ferredoxin-NADP+ reductase activity
RD04_RS09975	COG1840	ABC-type Fe3 transport system, periplasmic component
RD04_RS09980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RD04_RS09985	COG1178	ABC-type Fe3 transport system permease component
RD04_RS09990	COG3842	ATPase activity
RD04_RS09995	COG0583	DNA-binding transcription factor activity
RD04_RS10015	COG0501	Belongs to the peptidase M48B family
RD04_RS10025	COG0697	spore germination
RD04_RS10035	COG1846	Transcriptional regulator
RD04_RS10045	COG1566	PFAM secretion protein HlyD family protein
RD04_RS10050	COG2814	Major facilitator Superfamily
RD04_RS10055	COG0473	3-isopropylmalate dehydrogenase activity
RD04_RS10065	COG0747	negative chemotaxis
RD04_RS10075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD04_RS10090	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RD04_RS10115	COG1012	belongs to the aldehyde dehydrogenase family
RD04_RS10125	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RD04_RS10130	COG1115	amino acid carrier protein
RD04_RS10135	COG0433	COG0433 Predicted ATPase
RD04_RS10140	COG0217	transcriptional regulatory protein
RD04_RS10145	COG0151	Belongs to the GarS family
RD04_RS10150	COG0408	coproporphyrinogen oxidase activity
RD04_RS10155	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RD04_RS10160	COG0799	negative regulation of ribosome biogenesis
RD04_RS10165	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RD04_RS10170	COG0424	maF-like protein
RD04_RS10175	COG3468	outer membrane autotransporter barrel domain protein
RD04_RS10215	COG1530	ribonuclease E activity
RD04_RS10220	COG0077	Prephenate dehydratase
RD04_RS10235	COG1132	(ABC) transporter
RD04_RS10240	COG0859	PFAM glycosyl transferase family 9
RD04_RS10265	COG2194	sulfuric ester hydrolase activity
RD04_RS10270	COG0438	transferase activity, transferring glycosyl groups
RD04_RS10275	COG0463	Glycosyl transferase, family 2
RD04_RS10280	COG0726	polysaccharide deacetylase
RD04_RS10285	COG0438	transferase activity, transferring glycosyl groups
RD04_RS10300	COG1643	Atp-dependent helicase
RD04_RS10305	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RD04_RS10305	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RD04_RS10310	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
RD04_RS10320	COG0704	Plays a role in the regulation of phosphate uptake
RD04_RS10325	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
RD04_RS10330	COG1960	acyl-CoA dehydrogenase activity
RD04_RS10355	COG1177	transmembrane transport
RD04_RS10360	COG1176	ABC-type spermidine putrescine transport system, permease component I
RD04_RS10365	COG3842	ATPase activity
RD04_RS10370	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RD04_RS10385	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
RD04_RS10390	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD04_RS10400	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD04_RS10400	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD04_RS10420	COG0372	Belongs to the citrate synthase family
RD04_RS10425	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
RD04_RS10430	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RD04_RS10435	COG1053	succinate dehydrogenase
RD04_RS10440	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
RD04_RS10445	COG2009	succinate dehydrogenase
RD04_RS10450	COG2188	Transcriptional regulator
RD04_RS10455	COG0039	L-malate dehydrogenase activity
RD04_RS10485	COG1981	membrane
RD04_RS10510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RD04_RS10520	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
RD04_RS10550	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
RD04_RS10555	COG0148	phosphopyruvate hydratase activity
RD04_RS10565	COG2877	3-deoxy-8-phosphooctulonate synthase activity
RD04_RS10570	COG0504	CTP synthase activity
RD04_RS10595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD04_RS10605	COG0747	negative chemotaxis
RD04_RS10610	COG4172	Belongs to the ABC transporter superfamily
RD04_RS10615	COG1446	asparaginase
RD04_RS10645	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RD04_RS10660	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
RD04_RS10665	COG0697	spore germination
RD04_RS10670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RD04_RS10680	COG3193	protein, possibly involved in utilization of glycolate and propanediol
RD04_RS10685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RD04_RS10690	COG0791	NLP P60 protein
RD04_RS10705	COG0583	DNA-binding transcription factor activity
RD04_RS10720	COG0583	DNA-binding transcription factor activity
RD04_RS10730	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RD04_RS10745	COG0670	Belongs to the BI1 family
RD04_RS10750	COG3181	Tripartite tricarboxylate transporter family receptor
RD04_RS10770	COG1381	Involved in DNA repair and RecF pathway recombination
RD04_RS10775	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RD04_RS10780	COG0571	ribonuclease III activity
RD04_RS10785	COG0681	Belongs to the peptidase S26 family
RD04_RS10790	COG0481	GTPase activity
RD04_RS10795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RD04_RS10820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RD04_RS10825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RD04_RS10840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RD04_RS10845	COG0416	fatty acid biosynthetic process
RD04_RS10850	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RD04_RS10855	COG1399	metal-binding, possibly nucleic acid-binding protein
RD04_RS10860	COG0424	maF-like protein
RD04_RS10870	COG3023	N-Acetylmuramoyl-L-alanine amidase
RD04_RS10875	COG1289	transmembrane transporter activity
RD04_RS10885	COG3022	response to hydroperoxide
RD04_RS10900	COG0135	phosphoribosylanthranilate isomerase activity
RD04_RS10915	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD04_RS10920	COG0101	tRNA pseudouridine synthase activity
RD04_RS10930	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RD04_RS10935	COG0473	3-isopropylmalate dehydrogenase activity
RD04_RS10940	COG0066	3-isopropylmalate dehydratase activity
RD04_RS10945	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RD04_RS10955	COG1122	ATPase activity
RD04_RS10985	COG0437	4 iron, 4 sulfur cluster binding
RD04_RS10990	COG0243	molybdopterin cofactor binding
RD04_RS10990	COG3383	formate dehydrogenase (NAD+) activity
RD04_RS11020	COG0489	protein tyrosine kinase activity
RD04_RS11025	COG0746	molybdenum cofactor guanylyltransferase activity
RD04_RS11030	COG0303	'Molybdopterin
RD04_RS11035	COG1763	Mo-molybdopterin cofactor biosynthetic process
RD04_RS11045	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RD04_RS11050	COG5001	Diguanylate cyclase
RD04_RS11070	COG3842	ATPase activity
RD04_RS11080	COG0406	alpha-ribazole phosphatase activity
RD04_RS11090	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RD04_RS11095	COG0505	Belongs to the CarA family
RD04_RS11100	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RD04_RS11125	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
RD04_RS11130	COG1960	acyl-CoA dehydrogenase activity
RD04_RS11140	COG2867	negative regulation of translational initiation
RD04_RS11150	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RD04_RS11155	COG3706	GGDEF domain
RD04_RS11160	COG0330	HflC and HflK could
RD04_RS11175	COG0519	Catalyzes the synthesis of GMP from XMP
RD04_RS11175	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RD04_RS11185	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
RD04_RS11190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RD04_RS11195	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RD04_RS11200	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RD04_RS11210	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RD04_RS11215	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RD04_RS11220	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
RD04_RS11225	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RD04_RS11230	COG0750	zinc metalloprotease
RD04_RS11235	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RD04_RS11245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RD04_RS11250	COG0233	cytoplasmic translational termination
RD04_RS11255	COG0528	UMP kinase activity
RD04_RS11260	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RD04_RS11265	COG0052	Belongs to the universal ribosomal protein uS2 family
RD04_RS11270	COG0024	Methionine aminopeptidase
RD04_RS11275	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
RD04_RS11305	COG0285	dihydrofolate synthase activity
RD04_RS11340	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RD04_RS11350	COG1677	Flagellar hook-basal body complex protein FliE
RD04_RS11360	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RD04_RS11370	COG1157	protein secretion by the type III secretion system
RD04_RS11395	COG1580	Controls the rotational direction of flagella during chemotaxis
RD04_RS11415	COG1338	Plays a role in the flagellum-specific transport system
RD04_RS11435	COG0840	transmembrane signaling receptor activity
RD04_RS11440	COG0840	transmembrane signaling receptor activity
RD04_RS11445	COG0840	transmembrane signaling receptor activity
RD04_RS11455	COG1256	bacterial-type flagellum assembly
RD04_RS11465	COG1706	bacterial-type flagellum-dependent cell motility
RD04_RS11470	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
RD04_RS11485	COG1749	Flagellar hook protein flgE
RD04_RS11495	COG1558	bacterial-type flagellum-dependent cell motility
RD04_RS11500	COG1815	bacterial-type flagellum-dependent cell motility
RD04_RS11540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD04_RS11545	COG0765	amino acid transport
RD04_RS11550	COG1126	abc transporter atp-binding protein
RD04_RS11565	COG4948	Mandelate Racemase Muconate Lactonizing
RD04_RS11570	COG3181	Tripartite tricarboxylate transporter family receptor
RD04_RS11580	COG0066	3-isopropylmalate dehydratase activity
RD04_RS11595	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD04_RS11605	COG3181	Tripartite tricarboxylate transporter family receptor
RD04_RS11615	COG1802	Transcriptional regulator
RD04_RS11630	COG0583	DNA-binding transcription factor activity
RD04_RS11650	COG1695	Transcriptional regulator
RD04_RS11655	COG3568	Endonuclease Exonuclease Phosphatase
RD04_RS11660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RD04_RS11675	COG0392	lysyltransferase activity
RD04_RS11715	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RD04_RS11725	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RD04_RS11735	COG1640	4-alpha-glucanotransferase
RD04_RS11750	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
RD04_RS11780	COG0667	Aldo Keto reductase
RD04_RS11795	COG2259	Doxx family
RD04_RS11825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD04_RS11845	COG0386	Belongs to the glutathione peroxidase family
RD04_RS11850	COG0625	glutathione transferase activity
RD04_RS11865	COG0095	Lipoate-protein ligase
RD04_RS11880	COG0688	phosphatidylethanolamine metabolic process
RD04_RS11890	COG1464	Belongs to the NlpA lipoprotein family
RD04_RS11905	COG2363	Small membrane protein
RD04_RS11930	COG3842	ATPase activity
RD04_RS11935	COG0395	ABC-type sugar transport system, permease component
RD04_RS11940	COG1175	transmembrane transport
RD04_RS11945	COG1653	transport
RD04_RS11955	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
RD04_RS11970	COG0559	Belongs to the binding-protein-dependent transport system permease family
RD04_RS11990	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RD04_RS12005	COG0697	spore germination
RD04_RS12015	COG2311	Membrane
RD04_RS12040	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RD04_RS12050	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RD04_RS12055	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RD04_RS12060	COG1760	l-serine dehydratase
RD04_RS12065	COG1283	sodium-dependent phosphate transmembrane transporter activity
RD04_RS12070	COG0412	Dienelactone hydrolase
RD04_RS12085	COG1611	Belongs to the LOG family
RD04_RS12105	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RD04_RS12110	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RD04_RS12115	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RD04_RS12120	COG0195	Participates in both transcription termination and antitermination
RD04_RS12120	COG2251	uridine kinase activity
RD04_RS12125	COG0779	Required for maturation of 30S ribosomal subunits
RD04_RS12130	COG1187	pseudouridine synthase activity
RD04_RS12135	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RD04_RS12145	COG0583	DNA-binding transcription factor activity
RD04_RS12155	COG0523	cobalamin synthesis protein
RD04_RS12175	COG0625	glutathione transferase activity
RD04_RS12180	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RD04_RS12185	COG1047	Peptidyl-prolyl cis-trans
RD04_RS12190	COG2003	Belongs to the UPF0758 family
RD04_RS12195	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
RD04_RS12200	COG3483	tryptophan 2,3-dioxygenase activity
RD04_RS12205	COG0254	rRNA binding
RD04_RS12215	COG0534	Mate efflux family protein
RD04_RS12235	COG2304	oxidoreductase activity
RD04_RS12255	COG1028	Short-chain dehydrogenase reductase Sdr
RD04_RS12260	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RD04_RS12265	COG1562	ergosterol biosynthetic process
RD04_RS12270	COG1562	ergosterol biosynthetic process
RD04_RS12275	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
RD04_RS12275	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
RD04_RS12280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RD04_RS12290	COG0842	Transport permease protein
RD04_RS12295	COG1131	(ABC) transporter
RD04_RS12315	COG1477	protein flavinylation
RD04_RS12330	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
RD04_RS12345	COG5564	TIM-barrel signal transduction protein
RD04_RS12350	COG5441	Belongs to the UPF0261 family
RD04_RS12360	COG3468	outer membrane autotransporter barrel domain protein
RD04_RS12365	COG3468	outer membrane autotransporter barrel domain protein
RD04_RS12375	COG0542	response to heat
RD04_RS12380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RD04_RS12395	COG0494	nUDIX hydrolase
RD04_RS12400	COG3530	Putative quorum-sensing-regulated virulence factor
RD04_RS12410	COG1595	DNA-templated transcription, initiation
RD04_RS12415	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RD04_RS12450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD04_RS12455	COG0765	amino acid transport
RD04_RS12460	COG0765	amino acid transport
RD04_RS12495	COG0672	)-iron permease
RD04_RS12510	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
RD04_RS12515	COG1028	Short-chain dehydrogenase reductase Sdr
RD04_RS12520	COG3243	poly(R)-hydroxyalkanoic acid synthase
RD04_RS12530	COG0564	pseudouridine synthase activity
RD04_RS12540	COG1199	ATP-dependent helicase activity
RD04_RS12545	COG2183	response to ionizing radiation
RD04_RS12550	COG0180	Tryptophanyl-tRNA synthetase
RD04_RS12570	COG3181	Tripartite tricarboxylate transporter family receptor
RD04_RS12590	COG0583	DNA-binding transcription factor activity
RD04_RS12595	COG1028	Short-chain dehydrogenase reductase Sdr
RD04_RS12600	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RD04_RS12605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RD04_RS12610	COG0508	dehydrogenase complex catalyzes the overall conversion of
RD04_RS12615	COG0567	Dehydrogenase, E1 component
RD04_RS12625	COG1297	OPT oligopeptide transporter protein
RD04_RS12630	COG1297	OPT oligopeptide transporter protein
RD04_RS12635	COG1522	sequence-specific DNA binding
RD04_RS12645	COG0281	malic enzyme
RD04_RS12645	COG0280	phosphate acetyltransferase
RD04_RS12650	COG3539	Fimbrial protein
RD04_RS12665	COG0613	PHP domain protein
RD04_RS12700	COG0084	hydrolase, TatD family'
RD04_RS12705	COG1136	(ABC) transporter
RD04_RS12720	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RD04_RS12725	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RD04_RS12730	COG1028	Short-chain dehydrogenase reductase Sdr
RD04_RS12735	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RD04_RS12750	COG1022	Amp-dependent synthetase and ligase
RD04_RS12785	COG2205	protein histidine kinase activity
RD04_RS12790	COG0745	RESPONSE REGULATOR receiver
RD04_RS12795	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
RD04_RS12805	COG1295	ribonuclease BN
RD04_RS12820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RD04_RS12845	COG1534	Rna-binding protein
RD04_RS12850	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
RD04_RS12855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RD04_RS12865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RD04_RS12875	COG0248	Ppx GppA phosphatase
RD04_RS12900	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RD04_RS12920	COG2732	(Barnase) inhibitor
RD04_RS12930	COG0281	malic enzyme
RD04_RS12930	COG0280	phosphate acetyltransferase
RD04_RS12940	COG0436	Aminotransferase
RD04_RS12945	COG0741	lytic transglycosylase activity
RD04_RS12950	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
RD04_RS12975	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RD04_RS12975	COG1648	precorrin-2 dehydrogenase activity
RD04_RS12980	COG3468	outer membrane autotransporter barrel domain protein
RD04_RS12990	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RD04_RS12995	COG2027	D-alanyl-D-alanine carboxypeptidase
RD04_RS13000	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RD04_RS13005	COG0343	queuine tRNA-ribosyltransferase activity
RD04_RS13010	COG1862	Preprotein translocase
RD04_RS13015	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RD04_RS13020	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RD04_RS13035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RD04_RS13040	COG1702	phosphate starvation-inducible protein PhoH
RD04_RS13045	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RD04_RS13050	COG4535	Mg2 and Co2 transporter CorC
RD04_RS13060	COG0667	Aldo Keto reductase
RD04_RS13085	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
RD04_RS13090	COG0745	RESPONSE REGULATOR receiver
RD04_RS13095	COG2201	protein-glutamate methylesterase activity
RD04_RS13100	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RD04_RS13115	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RD04_RS13120	COG0840	transmembrane signaling receptor activity
RD04_RS13135	COG0745	RESPONSE REGULATOR receiver
RD04_RS13170	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RD04_RS13180	COG0739	heme binding
RD04_RS13190	COG0521	Mo-molybdopterin cofactor biosynthetic process
RD04_RS13195	COG0306	phosphate transporter
RD04_RS13200	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
RD04_RS13230	COG0625	glutathione transferase activity
RD04_RS13245	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RD04_RS13250	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RD04_RS13255	COG0126	phosphoglycerate kinase activity
RD04_RS13260	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RD04_RS13265	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RD04_RS13270	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RD04_RS13285	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RD04_RS13290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RD04_RS13300	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
RD04_RS13310	COG4566	intracellular signal transduction
RD04_RS13315	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RD04_RS13320	COG0339	signal peptide processing
RD04_RS13325	COG1999	signal sequence binding
RD04_RS13345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RD04_RS13355	COG1187	pseudouridine synthase activity
RD04_RS13360	COG3161	chorismate lyase activity
RD04_RS13365	COG2814	Major facilitator Superfamily
RD04_RS13375	COG0667	Aldo Keto reductase
RD04_RS13385	COG0335	large ribosomal subunit rRNA binding
RD04_RS13415	COG0175	sulfate reduction
RD04_RS13420	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RD04_RS13425	COG4208	sulfate ABC transporter
RD04_RS13430	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
RD04_RS13445	COG0450	alkyl hydroperoxide reductase
RD04_RS13450	COG1960	acyl-CoA dehydrogenase activity
RD04_RS13465	COG0123	including yeast histone deacetylase and acetoin utilization protein
RD04_RS13470	COG2951	lytic endotransglycosylase activity
RD04_RS13485	COG1555	photosystem II stabilization
RD04_RS13485	COG1596	polysaccharide export
RD04_RS13490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RD04_RS13495	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
RD04_RS13500	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
RD04_RS13520	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RD04_RS13525	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RD04_RS13530	COG0287	Prephenate dehydrogenase
RD04_RS13540	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RD04_RS13555	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RD04_RS13565	COG2814	Major facilitator Superfamily
RD04_RS13590	COG0583	DNA-binding transcription factor activity
RD04_RS13610	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RD04_RS13615	COG0303	'Molybdopterin
RD04_RS13620	COG0521	Mo-molybdopterin cofactor biosynthetic process
RD04_RS13635	COG0315	cyclic pyranopterin monophosphate synthase activity
RD04_RS13645	COG0412	Dienelactone hydrolase
RD04_RS13655	COG0678	peroxiredoxin activity
RD04_RS13665	COG0697	spore germination
RD04_RS13670	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RD04_RS13695	COG0789	Transcriptional regulator
RD04_RS13710	COG1028	Short-chain dehydrogenase reductase Sdr
RD04_RS13720	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RD04_RS13725	COG1845	cytochrome c oxidase, subunit III
RD04_RS13730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RD04_RS13740	COG0477	Major facilitator Superfamily
RD04_RS13770	COG3468	outer membrane autotransporter barrel domain protein
RD04_RS13780	COG1309	transcriptional regulator
RD04_RS13785	COG2271	Major facilitator Superfamily
RD04_RS13820	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RD04_RS13820	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RD04_RS13820	COG0506	proline dehydrogenase activity
RD04_RS13830	COG3008	intermembrane lipid transfer
RD04_RS13830	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RD04_RS13835	COG2995	paraquat-inducible protein a
RD04_RS13840	COG0542	response to heat
RD04_RS13845	COG4953	penicillin-binding protein 1C
RD04_RS13855	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RD04_RS13860	COG1278	Cold shock
RD04_RS13870	COG0183	Belongs to the thiolase family
RD04_RS13875	COG0038	chloride channel
RD04_RS13880	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RD04_RS13885	COG1570	exodeoxyribonuclease VII activity
RD04_RS13895	COG0811	peptide transport
RD04_RS13900	COG0848	biopolymer transport protein
RD04_RS13905	COG1663	tetraacyldisaccharide 4'-kinase activity
RD04_RS13910	COG2835	tetraacyldisaccharide 4'-kinase activity
RD04_RS13915	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
RD04_RS13920	COG0563	adenylate kinase activity
RD04_RS13930	COG0728	peptidoglycan biosynthetic process
RD04_RS13940	COG0268	Binds directly to 16S ribosomal RNA
RD04_RS13960	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RD04_RS13985	COG0436	Aminotransferase
RD04_RS13990	COG3737	Protein of unknown function (DUF498/DUF598)
RD04_RS13995	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RD04_RS14005	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RD04_RS14015	COG0305	Participates in initiation and elongation during chromosome replication
RD04_RS14025	COG0359	binds to the 23S rRNA
RD04_RS14030	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RD04_RS14035	COG2965	DNA replication, synthesis of RNA primer
RD04_RS14040	COG0360	Binds together with S18 to 16S ribosomal RNA
RD04_RS14045	COG1469	GTP cyclohydrolase I activity
RD04_RS14050	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RD04_RS14055	COG0142	geranyltranstransferase activity
RD04_RS14060	COG1722	exodeoxyribonuclease VII activity
RD04_RS14070	COG3181	Tripartite tricarboxylate transporter family receptor
RD04_RS14090	COG2239	Acts as a magnesium transporter
RD04_RS14100	COG2855	membrane
RD04_RS14110	COG1473	amidohydrolase
RD04_RS14115	COG0318	PFAM AMP-dependent synthetase and ligase
RD04_RS14135	COG1501	Belongs to the glycosyl hydrolase 31 family
RD04_RS14140	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RD04_RS14145	COG2011	ABC-type metal ion transport system permease component
RD04_RS14165	COG1454	alcohol dehydrogenase
RD04_RS14190	COG2186	Transcriptional regulator
RD04_RS14195	COG3181	Tripartite tricarboxylate transporter family receptor
RD04_RS14215	COG1175	transmembrane transport
RD04_RS14220	COG0395	ABC-type sugar transport system, permease component
RD04_RS14225	COG3842	ATPase activity
RD04_RS14230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RD04_RS14240	COG1653	transport
RD04_RS14260	COG2818	Glycosylase
RD04_RS14265	COG2982	Protein involved in outer membrane biogenesis
RD04_RS14275	COG1309	transcriptional regulator
RD04_RS14280	COG1028	Short-chain dehydrogenase reductase Sdr
RD04_RS14320	COG0583	DNA-binding transcription factor activity
RD04_RS14325	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
RD04_RS14330	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RD04_RS14345	COG1028	Short-chain dehydrogenase reductase Sdr
RD04_RS14350	COG0477	Major facilitator Superfamily
RD04_RS14360	COG0583	DNA-binding transcription factor activity
RD04_RS14365	COG1448	Aminotransferase
RD04_RS14370	COG1418	mRNA catabolic process
RD04_RS14395	COG1063	alcohol dehydrogenase
RD04_RS14415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD04_RS14425	COG0318	PFAM AMP-dependent synthetase and ligase
RD04_RS14435	COG1522	sequence-specific DNA binding
RD04_RS14440	COG3181	Tripartite tricarboxylate transporter family receptor
RD04_RS14445	COG0307	riboflavin synthase, alpha
RD04_RS14450	COG0154	amidase activity
RD04_RS14470	COG2807	transmembrane transport
RD04_RS14475	COG0590	tRNA wobble adenosine to inosine editing
RD04_RS14485	COG0583	DNA-binding transcription factor activity
RD04_RS14500	COG1902	pentaerythritol trinitrate reductase activity
RD04_RS14520	COG0559	Belongs to the binding-protein-dependent transport system permease family
RD04_RS14525	COG0251	oxidation-reduction process
RD04_RS14530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RD04_RS14540	COG1414	Transcriptional regulator
RD04_RS14545	COG1028	Short-chain dehydrogenase reductase Sdr
RD04_RS14560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD04_RS14575	COG1024	Enoyl-CoA hydratase
RD04_RS14580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD04_RS14585	COG0154	amidase activity
RD04_RS14625	COG3909	cytochrome
RD04_RS14630	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RD04_RS14635	COG0625	glutathione transferase activity
RD04_RS14640	COG0730	response to heat
RD04_RS14645	COG0482	sulfurtransferase activity
RD04_RS14650	COG0583	DNA-binding transcription factor activity
RD04_RS14685	COG2819	hydrolase of the alpha beta superfamily
RD04_RS14690	COG0247	lactate metabolic process
RD04_RS14695	COG0277	FAD linked oxidase domain protein
RD04_RS14700	COG0277	FAD linked oxidase domain protein
RD04_RS14705	COG0277	FAD linked oxidase domain protein
RD04_RS14710	COG3064	Membrane
RD04_RS14710	COG3210	domain, Protein
RD04_RS14710	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
RD04_RS14710	COG3064	Membrane
RD04_RS14710	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
RD04_RS14710	COG3210	domain, Protein
RD04_RS14715	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RD04_RS14720	COG0312	modulator of DNA gyrase
RD04_RS14755	COG1666	GTP binding
RD04_RS14800	COG3220	belongs to the UPF0276 family
RD04_RS14820	COG0640	Transcriptional regulator
RD04_RS14825	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RD04_RS14830	COG1845	cytochrome c oxidase, subunit III
RD04_RS14835	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RD04_RS14845	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
RD04_RS14880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD04_RS14885	COG0583	DNA-binding transcription factor activity
RD04_RS14915	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RD04_RS14915	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RD04_RS14930	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RD04_RS14935	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RD04_RS14945	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RD04_RS14960	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
RD04_RS14965	COG0316	Belongs to the HesB IscA family
RD04_RS14975	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RD04_RS14980	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RD04_RS14985	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RD04_RS14990	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD04_RS14995	COG0312	modulator of DNA gyrase
RD04_RS15000	COG3028	Belongs to the UPF0307 family
RD04_RS15015	COG1116	anion transmembrane transporter activity
RD04_RS15020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD04_RS15025	COG1335	isochorismatase
RD04_RS15030	COG0346	lactoylglutathione lyase activity
RD04_RS15035	COG0513	Belongs to the DEAD box helicase family
RD04_RS15040	COG3069	C4-dicarboxylate transmembrane transporter activity
RD04_RS15060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RD04_RS15075	COG1522	sequence-specific DNA binding
RD04_RS15110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RD04_RS15115	COG1696	Membrane protein involved in D-alanine export
RD04_RS15140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RD04_RS15150	COG2264	protein methyltransferase activity
RD04_RS15155	COG0439	Biotin carboxylase
RD04_RS15160	COG0511	ligase activity, forming carbon-carbon bonds
RD04_RS15165	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RD04_RS15170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RD04_RS15175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RD04_RS15180	COG3150	esterase
RD04_RS15185	COG0557	exoribonuclease II activity
RD04_RS15195	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RD04_RS15220	COG1522	sequence-specific DNA binding
RD04_RS15225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD04_RS15230	COG1028	Short-chain dehydrogenase reductase Sdr
RD04_RS15250	COG0653	protein targeting
RD04_RS15255	COG0739	heme binding
RD04_RS15265	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
RD04_RS15270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RD04_RS15280	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RD04_RS15285	COG1181	Belongs to the D-alanine--D-alanine ligase family
RD04_RS15290	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RD04_RS15295	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RD04_RS15305	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RD04_RS15310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RD04_RS15315	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RD04_RS15325	COG3116	cell division
RD04_RS15330	COG0275	rRNA processing
RD04_RS15335	COG2001	Belongs to the MraZ family
RD04_RS15345	COG0488	(ABC) transporter
RD04_RS15350	COG0418	dihydroorotase activity
RD04_RS15355	COG1473	amidohydrolase
RD04_RS15405	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RD04_RS15410	COG4654	Cytochrome c, class I
RD04_RS15415	COG0129	dihydroxy-acid dehydratase activity
RD04_RS15420	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RD04_RS15475	COG2084	Dehydrogenase
RD04_RS15480	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RD04_RS15490	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RD04_RS15495	COG0513	Belongs to the DEAD box helicase family
RD04_RS15505	COG0617	tRNA 3'-terminal CCA addition
RD04_RS15520	COG0477	Major facilitator Superfamily
RD04_RS15530	COG0583	DNA-binding transcription factor activity
RD04_RS15545	COG1950	PFAM Membrane protein of
RD04_RS15550	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
RD04_RS15565	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RD04_RS15575	COG1560	Kdo2-lipid A biosynthetic process
RD04_RS15580	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RD04_RS15590	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
RD04_RS15600	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
RD04_RS15610	COG0803	Belongs to the bacterial solute-binding protein 9 family
RD04_RS15630	COG0735	belongs to the Fur family
RD04_RS15635	COG0523	cobalamin synthesis protein
RD04_RS15645	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
RD04_RS15650	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
RD04_RS15660	COG2096	Adenosyltransferase
RD04_RS15670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RD04_RS15675	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
RD04_RS15735	COG1280	lysine exporter protein (LysE YggA)
RD04_RS15750	COG0405	Gamma-glutamyltransferase
RD04_RS15760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD04_RS15785	COG1309	transcriptional regulator
RD04_RS15800	COG0745	RESPONSE REGULATOR receiver
RD04_RS15845	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RD04_RS15865	COG0582	viral genome integration into host DNA
RD04_RS15870	COG0012	GTP binding
RD04_RS15880	COG0193	aminoacyl-tRNA hydrolase activity
RD04_RS15885	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RD04_RS15890	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RD04_RS15900	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RD04_RS15905	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
RD04_RS15915	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RD04_RS15940	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
RD04_RS15950	COG1368	sulfuric ester hydrolase activity
RD04_RS15955	COG0642	Histidine kinase
RD04_RS15960	COG0745	RESPONSE REGULATOR receiver
RD04_RS15965	COG0277	FAD linked oxidase domain protein
RD04_RS15980	COG0166	Belongs to the GPI family
RD04_RS15985	COG0438	transferase activity, transferring glycosyl groups
RD04_RS15990	COG0438	transferase activity, transferring glycosyl groups
RD04_RS16005	COG0438	transferase activity, transferring glycosyl groups
RD04_RS16020	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
RD04_RS16025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RD04_RS16030	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
RD04_RS16040	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RD04_RS16050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RD04_RS16055	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RD04_RS16065	COG0747	negative chemotaxis
RD04_RS16070	COG0601	transmembrane transport
RD04_RS16075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD04_RS16095	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RD04_RS16100	COG0830	nickel cation binding
RD04_RS16110	COG0804	urea catabolic process
RD04_RS16115	COG0832	Belongs to the urease beta subunit family
RD04_RS16125	COG0831	urea catabolic process
RD04_RS16130	COG0829	nickel cation binding
RD04_RS16140	COG0633	Ferredoxin
RD04_RS16155	COG2188	Transcriptional regulator
RD04_RS16180	COG2719	SpoVR family
RD04_RS16185	COG2718	Belongs to the UPF0229 family
RD04_RS16200	COG1028	Short-chain dehydrogenase reductase Sdr
RD04_RS16205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD04_RS16220	COG1960	acyl-CoA dehydrogenase activity
RD04_RS16265	COG0183	Belongs to the thiolase family
RD04_RS16270	COG2030	dehydratase
RD04_RS16315	COG0328	RNA-DNA hybrid ribonuclease activity
RD04_RS16320	COG2226	methyltransferase
RD04_RS16325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RD04_RS16330	COG0741	lytic transglycosylase activity
RD04_RS16330	COG1388	LysM domain
RD04_RS16350	COG2979	Protein of unknown function (DUF533)
RD04_RS16385	COG1271	oxidase subunit
RD04_RS16390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RD04_RS16395	COG0850	regulation of cytokinetic process
RD04_RS16400	COG2894	cell division
RD04_RS16405	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
RD04_RS16425	COG0488	(ABC) transporter
RD04_RS16435	COG0601	transmembrane transport
RD04_RS16445	COG1215	transferase activity, transferring glycosyl groups
RD04_RS16460	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RD04_RS16470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RD04_RS16490	COG0318	PFAM AMP-dependent synthetase and ligase
RD04_RS16495	COG2188	Transcriptional regulator
RD04_RS16500	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RD04_RS16505	COG2814	Major facilitator Superfamily
RD04_RS16515	COG0259	pyridoxamine-phosphate oxidase activity
RD04_RS16520	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RD04_RS16535	COG0583	DNA-binding transcription factor activity
RD04_RS16540	COG1960	acyl-CoA dehydrogenase activity
RD04_RS16565	COG0134	indole-3-glycerol-phosphate synthase activity
RD04_RS16570	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RD04_RS16575	COG0512	Glutamine amidotransferase of anthranilate synthase
RD04_RS16585	COG0546	phosphoglycolate phosphatase activity
RD04_RS16590	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RD04_RS16595	COG2967	ApaG domain
RD04_RS16600	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
RD04_RS16605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RD04_RS16610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RD04_RS16615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RD04_RS16625	COG0037	tRNA processing
RD04_RS16635	COG3634	alkyl hydroperoxide reductase activity
RD04_RS16640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RD04_RS16645	COG1024	Enoyl-CoA hydratase
RD04_RS16670	COG0356	it plays a direct role in the translocation of protons across the membrane
RD04_RS16680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RD04_RS16685	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RD04_RS16690	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RD04_RS16695	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RD04_RS16700	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RD04_RS16705	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RD04_RS16715	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
RD04_RS16720	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RD04_RS16725	COG0210	DNA helicase
RD04_RS16735	COG2195	Cleaves the N-terminal amino acid of tripeptides
RD04_RS16745	COG4608	Belongs to the ABC transporter superfamily
RD04_RS16750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD04_RS16755	COG0601	transmembrane transport
RD04_RS16775	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RD04_RS16780	COG1024	Enoyl-CoA hydratase
RD04_RS16785	COG1024	Enoyl-CoA hydratase
RD04_RS16810	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD04_RS16825	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RD04_RS16825	COG2010	Cytochrome c
RD04_RS16830	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
RD04_RS16840	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RD04_RS16845	COG1137	ATPase activity
RD04_RS16860	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
RD04_RS16870	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
RD04_RS16905	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RD04_RS16910	COG3568	Endonuclease Exonuclease Phosphatase
RD04_RS16915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RD04_RS16945	COG0154	amidase activity
RD04_RS16955	COG1414	Transcriptional regulator
RD04_RS16970	COG1024	Enoyl-CoA hydratase
RD04_RS16970	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD04_RS17000	COG1660	Displays ATPase and GTPase activities
RD04_RS17005	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RD04_RS17045	COG3181	Tripartite tricarboxylate transporter family receptor
RD04_RS17055	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
RD04_RS17060	COG2890	protein-(glutamine-N5) methyltransferase activity
RD04_RS17065	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RD04_RS17070	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RD04_RS17110	COG1960	acyl-CoA dehydrogenase activity
RD04_RS17120	COG0183	Belongs to the thiolase family
RD04_RS17125	COG1522	sequence-specific DNA binding
RD04_RS17130	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RD04_RS17150	COG1024	Enoyl-CoA hydratase
RD04_RS17165	COG0604	alcohol dehydrogenase
RD04_RS17170	COG2072	flavoprotein involved in K transport
RD04_RS17185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RD04_RS17195	COG1960	acyl-CoA dehydrogenase activity
RD04_RS17200	COG1960	acyl-CoA dehydrogenase activity
RD04_RS17205	COG0277	FAD linked oxidase domain protein
RD04_RS17215	COG3181	Tripartite tricarboxylate transporter family receptor
RD04_RS17240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RD04_RS17250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD04_RS17255	COG3181	Tripartite tricarboxylate transporter family receptor
RD04_RS17260	COG1960	acyl-CoA dehydrogenase activity
RD04_RS17280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RD04_RS17285	COG1024	Enoyl-CoA hydratase
RD04_RS17290	COG1960	acyl-CoA dehydrogenase activity
RD04_RS17310	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RD04_RS17315	COG0022	dehydrogenase e1 component
RD04_RS17320	COG1024	Enoyl-CoA hydratase
RD04_RS17325	COG0508	dehydrogenase complex catalyzes the overall conversion of
RD04_RS17345	COG0683	leucine binding
RD04_RS17350	COG0559	Belongs to the binding-protein-dependent transport system permease family
RD04_RS17355	COG0411	ABC transporter
RD04_RS17365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RD04_RS17380	COG3181	Tripartite tricarboxylate transporter family receptor
RD04_RS17405	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RD04_RS17410	COG0793	Belongs to the peptidase S41A family
RD04_RS17415	COG4942	peptidase
RD04_RS17420	COG0588	phosphoglycerate mutase activity
RD04_RS17425	COG1054	Belongs to the UPF0176 family
RD04_RS17430	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RD04_RS17435	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
RD04_RS17440	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RD04_RS17445	COG3181	Tripartite tricarboxylate transporter family receptor
RD04_RS17460	COG2226	methyltransferase
RD04_RS17465	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
RD04_RS17480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD04_RS17485	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
RD04_RS17510	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD04_RS17535	COG1335	isochorismatase
RD04_RS17540	COG2309	aminopeptidase activity
RD04_RS17545	COG0596	Alpha beta hydrolase
RD04_RS17550	COG3473	Maleate cis-trans isomerase
RD04_RS17560	COG2068	MobA-Related Protein
RD04_RS17585	COG2204	response regulator
RD04_RS17590	COG5000	phosphorelay sensor kinase activity
RD04_RS17600	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RD04_RS17600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RD04_RS17610	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
RD04_RS17630	COG0583	DNA-binding transcription factor activity
RD04_RS17645	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RD04_RS17650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RD04_RS17655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD04_RS17670	COG0758	DNA mediated transformation
RD04_RS17675	COG1522	sequence-specific DNA binding
RD04_RS17685	COG0242	peptide deformylase activity
RD04_RS17695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RD04_RS17705	COG0546	phosphoglycolate phosphatase activity
RD04_RS17725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RD04_RS17730	COG1942	4-Oxalocrotonate Tautomerase
RD04_RS17735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD04_RS17755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RD04_RS17775	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RD04_RS17780	COG1024	Enoyl-CoA hydratase
RD04_RS17785	COG1414	Transcriptional regulator
RD04_RS17790	COG0318	PFAM AMP-dependent synthetase and ligase
RD04_RS17795	COG3181	Tripartite tricarboxylate transporter family receptor
RD04_RS17825	COG0583	DNA-binding transcription factor activity
RD04_RS17840	COG3422	double-strand break repair
RD04_RS17845	COG0330	HflC and HflK could
RD04_RS17855	COG0251	oxidation-reduction process
RD04_RS17900	COG3723	Recombinational DNA repair protein, rece pathway
RD04_RS17935	COG0582	viral genome integration into host DNA
RD04_RS17965	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RD04_RS17975	COG0706	membrane insertase activity
RD04_RS17980	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RD04_RS17985	COG0594	ribonuclease P activity
RD04_RS17990	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RD04_RS17995	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RD04_RS18010	COG1414	Transcriptional regulator
RD04_RS18015	COG0154	amidase activity
RD04_RS18030	COG1304	FMN binding
RD04_RS18050	COG1960	acyl-CoA dehydrogenase activity
RD04_RS18070	COG1960	acyl-CoA dehydrogenase activity
RD04_RS18080	COG0183	Belongs to the thiolase family
RD04_RS18085	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RD04_RS18100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RD04_RS18105	COG3181	Tripartite tricarboxylate transporter family receptor
RD04_RS18115	COG2358	TRAP transporter, solute receptor (TAXI family
RD04_RS18125	COG1629	transport
RD04_RS18130	COG2922	Belongs to the Smg family
RD04_RS18155	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
RD04_RS18160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD04_RS18165	COG1028	Short-chain dehydrogenase reductase Sdr
RD04_RS18170	COG1012	belongs to the aldehyde dehydrogenase family
RD04_RS18180	COG0028	Belongs to the TPP enzyme family
RD04_RS18185	COG1522	sequence-specific DNA binding
RD04_RS18190	COG3781	membrane
RD04_RS18200	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RD04_RS18220	COG4206	TonB-dependent receptor
RD04_RS18225	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RD04_RS18230	COG2022	thiamine diphosphate biosynthetic process
RD04_RS18235	COG0351	phosphomethylpyrimidine kinase
RD04_RS18240	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RD04_RS18255	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RD04_RS18265	COG0628	permease
RD04_RS18275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RD04_RS18285	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RD04_RS18290	COG0049	tRNA binding
RD04_RS18295	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RD04_RS18300	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RD04_RS18305	COG0051	transcription antitermination factor activity, RNA binding
RD04_RS18310	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RD04_RS18315	COG0088	Forms part of the polypeptide exit tunnel
RD04_RS18320	COG0089	rRNA binding
RD04_RS18325	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RD04_RS18330	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RD04_RS18335	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RD04_RS18340	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RD04_RS18345	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RD04_RS18350	COG0255	Belongs to the universal ribosomal protein uL29 family
RD04_RS18355	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RD04_RS18375	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RD04_RS18380	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RD04_RS18385	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RD04_RS18390	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RD04_RS18395	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RD04_RS18400	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RD04_RS18405	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RD04_RS18410	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RD04_RS18415	COG1841	ribosomal large subunit assembly
RD04_RS18420	COG0200	Binds to the 23S rRNA
RD04_RS18425	COG0201	protein transport
RD04_RS18430	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RD04_RS18435	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RD04_RS18440	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RD04_RS18445	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RD04_RS18450	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RD04_RS18455	COG0202	RNA polymerase activity
RD04_RS18460	COG0203	ribosomal protein L17
RD04_RS18470	COG1324	tolerance protein
RD04_RS18475	COG4232	protein-disulfide reductase activity
RD04_RS18490	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RD04_RS18500	COG1333	cytochrome c biogenesis protein
RD04_RS18505	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RD04_RS18515	COG1965	Belongs to the frataxin family
RD04_RS18525	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RD04_RS18530	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RD04_RS18535	COG0232	Belongs to the dGTPase family. Type 2 subfamily
RD04_RS18550	COG2814	Major facilitator Superfamily
RD04_RS18555	COG0629	single-stranded DNA binding
RD04_RS18595	COG0402	S-adenosylhomocysteine deaminase activity
RD04_RS18605	COG0438	transferase activity, transferring glycosyl groups
RD04_RS18625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD04_RS18650	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RD04_RS18655	COG2186	Transcriptional regulator
RD04_RS18675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RD04_RS18680	COG1956	GAF domain-containing protein
RD04_RS18685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RD04_RS18695	COG1652	LysM domain
RD04_RS18710	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RD04_RS18725	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RD04_RS18750	COG3181	Tripartite tricarboxylate transporter family receptor
RD04_RS18765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD04_RS18780	COG1024	Enoyl-CoA hydratase
RD04_RS18795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD04_RS18800	COG1309	transcriptional regulator
RD04_RS18805	COG2816	NAD+ diphosphatase activity
RD04_RS18810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RD04_RS18895	COG2814	Major facilitator Superfamily
RD04_RS18900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RD04_RS18920	COG1999	signal sequence binding
RD04_RS18925	COG0109	protoheme IX farnesyltransferase activity
RD04_RS18965	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RD04_RS18985	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RD04_RS18990	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RD04_RS19000	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
RD04_RS19005	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
RD04_RS19015	COG0070	glutamate synthase
RD04_RS19015	COG0069	glutamate synthase activity
RD04_RS19015	COG0067	glutamate synthase
RD04_RS19025	COG3047	cAMP biosynthetic process
RD04_RS19035	COG1127	ABC transporter
RD04_RS19040	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RD04_RS19045	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RD04_RS19050	COG2853	Lipoprotein
RD04_RS19060	COG1131	(ABC) transporter
RD04_RS19065	COG0842	Transport permease protein
RD04_RS19080	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RD04_RS19085	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RD04_RS19090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RD04_RS19095	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RD04_RS19100	COG0131	Imidazoleglycerol-phosphate dehydratase
RD04_RS19110	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RD04_RS19115	COG0107	imidazoleglycerol-phosphate synthase activity
RD04_RS19120	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RD04_RS19125	COG0140	phosphoribosyl-ATP diphosphatase activity
RD04_RS19130	COG0537	adenosine 5'-monophosphoramidase activity
RD04_RS19135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RD04_RS19140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RD04_RS19155	COG3181	Tripartite tricarboxylate transporter family receptor
RD04_RS19190	COG3702	type iv secretory pathway
RD04_RS19195	COG3451	type IV secretory pathway VirB4
RD04_RS19210	COG3736	Type IV secretory pathway, component VirB8
RD04_RS19215	COG3504	Conjugal transfer protein
RD04_RS19220	COG2948	multi-organism process
RD04_RS19225	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
RD04_RS19235	COG0697	spore germination
RD04_RS19255	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RD04_RS19260	COG0747	negative chemotaxis
RD04_RS19265	COG0601	transmembrane transport
RD04_RS19270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD04_RS19275	COG0444	Belongs to the ABC transporter superfamily
RD04_RS19285	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
RD04_RS19295	COG0494	nUDIX hydrolase
RD04_RS19330	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
RD04_RS19335	COG0237	dephospho-CoA kinase activity
RD04_RS19340	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
RD04_RS19355	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RD04_RS19360	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
RD04_RS19370	COG0477	Major facilitator Superfamily
RD04_RS19375	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RD04_RS19390	COG1126	abc transporter atp-binding protein
RD04_RS19395	COG0765	amino acid transport
RD04_RS19400	COG4597	amino acid ABC transporter
RD04_RS19405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD04_RS19410	COG2884	Cell division ATP-binding protein ftsE
RD04_RS19415	COG2177	Part of the ABC transporter FtsEX involved in
RD04_RS19420	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
RD04_RS19430	COG1194	a g-specific adenine glycosylase
RD04_RS19440	COG2226	methyltransferase
RD04_RS19455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD04_RS19460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD04_RS19475	COG1024	Enoyl-CoA hydratase
RD04_RS19495	COG1024	Enoyl-CoA hydratase
RD04_RS19500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD04_RS19505	COG3181	Tripartite tricarboxylate transporter family receptor
RD04_RS19515	COG0753	catalase activity
RD04_RS19520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD04_RS19525	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
RD04_RS19535	COG2175	clavaminate synthase activity
RD04_RS19540	COG1473	amidohydrolase
RD04_RS19545	COG4608	Belongs to the ABC transporter superfamily
RD04_RS19550	COG0444	Belongs to the ABC transporter superfamily
RD04_RS19565	COG0747	negative chemotaxis
RD04_RS19570	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RD04_RS19605	COG0436	Aminotransferase
RD04_RS19610	COG1278	Cold shock