locus-tag	class	description
RD12_RS00005	COG0445	tRNA wobble uridine modification
RD12_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
RD12_RS00015	COG1192	Involved in chromosome partitioning
RD12_RS00025	COG1475	DNA binding
RD12_RS00030	COG0252	asparaginase activity
RD12_RS00055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RD12_RS00065	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RD12_RS00075	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RD12_RS00080	COG0081	regulation of translation
RD12_RS00085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RD12_RS00090	COG0222	ribosome binding
RD12_RS00095	COG0085	RNA polymerase activity
RD12_RS00100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RD12_RS00140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD12_RS00165	COG1024	Enoyl-CoA hydratase
RD12_RS00185	COG0752	glycyl-tRNA synthetase alpha subunit
RD12_RS00190	COG0751	glycine-tRNA ligase activity
RD12_RS00195	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RD12_RS00200	COG0204	Acyl-transferase
RD12_RS00215	COG0242	peptide deformylase activity
RD12_RS00250	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RD12_RS00260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RD12_RS00265	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RD12_RS00265	COG2813	Specifically methylates the guanine in position
RD12_RS00275	COG2223	nitrite transmembrane transporter activity
RD12_RS00285	COG1794	racemase activity, acting on amino acids and derivatives
RD12_RS00290	COG1126	abc transporter atp-binding protein
RD12_RS00295	COG0765	amino acid transport
RD12_RS00300	COG0765	amino acid transport
RD12_RS00305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD12_RS00365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD12_RS00395	COG0326	Molecular chaperone. Has ATPase activity
RD12_RS00400	COG0625	glutathione transferase activity
RD12_RS00415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RD12_RS00420	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RD12_RS00450	COG0438	transferase activity, transferring glycosyl groups
RD12_RS00455	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RD12_RS00460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RD12_RS00490	COG0859	PFAM glycosyl transferase family 9
RD12_RS00505	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
RD12_RS00515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RD12_RS00520	COG1127	ABC transporter
RD12_RS00545	COG1686	Belongs to the peptidase S11 family
RD12_RS00555	COG2921	Belongs to the UPF0250 family
RD12_RS00560	COG0321	lipoyl(octanoyl) transferase activity
RD12_RS00565	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RD12_RS00600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RD12_RS00610	COG0018	arginyl-trna synthetase
RD12_RS00630	COG0395	ABC-type sugar transport system, permease component
RD12_RS00635	COG1175	transmembrane transport
RD12_RS00640	COG1653	transport
RD12_RS00645	COG3842	ATPase activity
RD12_RS00650	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RD12_RS00660	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RD12_RS00680	COG1609	Transcriptional regulator
RD12_RS00690	COG0154	amidase activity
RD12_RS00695	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RD12_RS00705	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RD12_RS00715	COG0583	DNA-binding transcription factor activity
RD12_RS00730	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RD12_RS00735	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RD12_RS00750	COG1802	Transcriptional regulator
RD12_RS00765	COG1024	Enoyl-CoA hydratase
RD12_RS00780	COG3181	Tripartite tricarboxylate transporter family receptor
RD12_RS00795	COG1984	allophanate hydrolase subunit 2
RD12_RS00800	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RD12_RS00810	COG0583	DNA-binding transcription factor activity
RD12_RS00815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RD12_RS00825	COG5002	protein histidine kinase activity
RD12_RS00835	COG5002	protein histidine kinase activity
RD12_RS00840	COG0745	RESPONSE REGULATOR receiver
RD12_RS00845	COG2226	methyltransferase
RD12_RS00860	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RD12_RS00880	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
RD12_RS00890	COG0513	Belongs to the DEAD box helicase family
RD12_RS00895	COG1280	lysine exporter protein (LysE YggA)
RD12_RS00900	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
RD12_RS00935	COG1054	Belongs to the UPF0176 family
RD12_RS00940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RD12_RS00940	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RD12_RS00950	COG0489	protein tyrosine kinase activity
RD12_RS00965	COG0717	Belongs to the dCTP deaminase family
RD12_RS00995	COG2081	HI0933 family
RD12_RS01005	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RD12_RS01015	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RD12_RS01020	COG0509	glycine decarboxylation via glycine cleavage system
RD12_RS01025	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RD12_RS01025	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RD12_RS01065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RD12_RS01080	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RD12_RS01090	COG1414	Transcriptional regulator
RD12_RS01095	COG1028	Short-chain dehydrogenase reductase Sdr
RD12_RS01100	COG2031	fatty acid transporter
RD12_RS01105	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD12_RS01115	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
RD12_RS01120	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
RD12_RS01130	COG4257	antibiotic catabolic process
RD12_RS01150	COG1012	belongs to the aldehyde dehydrogenase family
RD12_RS01155	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
RD12_RS01160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RD12_RS01185	COG1028	Short-chain dehydrogenase reductase Sdr
RD12_RS01195	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RD12_RS01205	COG2188	Transcriptional regulator
RD12_RS01210	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD12_RS01235	COG0617	tRNA 3'-terminal CCA addition
RD12_RS01250	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RD12_RS01255	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RD12_RS01260	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RD12_RS01265	COG0586	Pfam SNARE associated Golgi protein
RD12_RS01270	COG0860	N-Acetylmuramoyl-L-alanine amidase
RD12_RS01275	COG0802	atpase or kinase
RD12_RS01280	COG0114	fumarate hydratase activity
RD12_RS01290	COG3181	Tripartite tricarboxylate transporter family receptor
RD12_RS01300	COG0405	Gamma-glutamyltransferase
RD12_RS01305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD12_RS01315	COG1960	acyl-CoA dehydrogenase activity
RD12_RS01340	COG1294	oxidase, subunit
RD12_RS01350	COG4988	ABC transporter
RD12_RS01355	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
RD12_RS01360	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RD12_RS01375	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RD12_RS01400	COG2969	positive regulation of protein catabolic process
RD12_RS01405	COG0625	glutathione transferase activity
RD12_RS01410	COG2857	Cytochrome c1
RD12_RS01415	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RD12_RS01420	COG0723	plastoquinol--plastocyanin reductase activity
RD12_RS01425	COG1970	mechanosensitive ion channel activity
RD12_RS01430	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RD12_RS01445	COG2808	Putative FMN-binding domain
RD12_RS01450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RD12_RS01455	COG0747	negative chemotaxis
RD12_RS01460	COG0657	acetylesterase activity
RD12_RS01470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RD12_RS01475	COG2207	Transcriptional regulator
RD12_RS01480	COG0129	dihydroxy-acid dehydratase activity
RD12_RS01485	COG2814	Major facilitator Superfamily
RD12_RS01490	COG0583	DNA-binding transcription factor activity
RD12_RS01500	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
RD12_RS01570	COG1024	Enoyl-CoA hydratase
RD12_RS01575	COG1960	acyl-CoA dehydrogenase activity
RD12_RS01600	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RD12_RS01605	COG0352	thiamine-phosphate diphosphorylase activity
RD12_RS01620	COG1678	Uncharacterized ACR, COG1678
RD12_RS01625	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RD12_RS01630	COG0540	Belongs to the ATCase OTCase family
RD12_RS01645	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RD12_RS01655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RD12_RS01690	COG1234	tRNA 3'-trailer cleavage
RD12_RS01735	COG1683	Conserved Protein
RD12_RS01740	COG1120	ATPase activity
RD12_RS01745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RD12_RS01750	COG4558	Periplasmic binding protein
RD12_RS01755	COG3720	iron ion transport
RD12_RS01765	COG3712	iron ion homeostasis
RD12_RS01770	COG1595	DNA-templated transcription, initiation
RD12_RS01805	COG1802	Transcriptional regulator
RD12_RS01815	COG3069	C4-dicarboxylate transmembrane transporter activity
RD12_RS01825	COG1012	belongs to the aldehyde dehydrogenase family
RD12_RS01860	COG2860	membrane
RD12_RS01865	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RD12_RS01870	COG0708	Exodeoxyribonuclease III
RD12_RS01875	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RD12_RS01880	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RD12_RS01885	COG0154	amidase activity
RD12_RS01890	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RD12_RS01895	COG1077	Cell shape determining protein MreB Mrl
RD12_RS01900	COG1792	Involved in formation and maintenance of cell shape
RD12_RS01910	COG0768	penicillin binding
RD12_RS01915	COG0772	Belongs to the SEDS family
RD12_RS01920	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RD12_RS01925	COG0471	metal ion transport
RD12_RS01930	COG1309	transcriptional regulator
RD12_RS01940	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RD12_RS01955	COG2823	Periplasmic or secreted lipoprotein
RD12_RS01960	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
RD12_RS01975	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RD12_RS01995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD12_RS02005	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD12_RS02030	COG0492	ferredoxin-NADP+ reductase activity
RD12_RS02040	COG3181	Tripartite tricarboxylate transporter family receptor
RD12_RS02045	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD12_RS02045	COG1024	Enoyl-CoA hydratase
RD12_RS02050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD12_RS02055	COG0028	Belongs to the TPP enzyme family
RD12_RS02080	COG3181	Tripartite tricarboxylate transporter family receptor
RD12_RS02090	COG0697	spore germination
RD12_RS02115	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RD12_RS02120	COG0463	Glycosyl transferase, family 2
RD12_RS02135	COG0786	glutamate:sodium symporter activity
RD12_RS02145	COG2031	fatty acid transporter
RD12_RS02160	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RD12_RS02165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RD12_RS02185	COG3181	Tripartite tricarboxylate transporter family receptor
RD12_RS02195	COG0277	FAD linked oxidase domain protein
RD12_RS02200	COG1960	acyl-CoA dehydrogenase activity
RD12_RS02205	COG1960	acyl-CoA dehydrogenase activity
RD12_RS02215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RD12_RS02230	COG2072	flavoprotein involved in K transport
RD12_RS02235	COG0604	alcohol dehydrogenase
RD12_RS02250	COG1024	Enoyl-CoA hydratase
RD12_RS02270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RD12_RS02275	COG1522	sequence-specific DNA binding
RD12_RS02280	COG0183	Belongs to the thiolase family
RD12_RS02290	COG1960	acyl-CoA dehydrogenase activity
RD12_RS02330	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RD12_RS02335	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RD12_RS02340	COG2890	protein-(glutamine-N5) methyltransferase activity
RD12_RS02345	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
RD12_RS02355	COG3181	Tripartite tricarboxylate transporter family receptor
RD12_RS02395	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RD12_RS02400	COG1660	Displays ATPase and GTPase activities
RD12_RS02410	COG2010	Cytochrome c
RD12_RS02410	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RD12_RS02415	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
RD12_RS02425	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RD12_RS02430	COG1137	ATPase activity
RD12_RS02445	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
RD12_RS02455	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
RD12_RS02490	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RD12_RS02495	COG3568	Endonuclease Exonuclease Phosphatase
RD12_RS02500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RD12_RS02530	COG0154	amidase activity
RD12_RS02540	COG1414	Transcriptional regulator
RD12_RS02555	COG1024	Enoyl-CoA hydratase
RD12_RS02555	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD12_RS02565	COG2132	Multicopper oxidase
RD12_RS02595	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD12_RS02620	COG1024	Enoyl-CoA hydratase
RD12_RS02625	COG1024	Enoyl-CoA hydratase
RD12_RS02630	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RD12_RS02650	COG0601	transmembrane transport
RD12_RS02655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD12_RS02660	COG4608	Belongs to the ABC transporter superfamily
RD12_RS02670	COG2195	Cleaves the N-terminal amino acid of tripeptides
RD12_RS02680	COG0210	DNA helicase
RD12_RS02685	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RD12_RS02690	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
RD12_RS02700	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RD12_RS02705	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RD12_RS02710	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RD12_RS02715	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RD12_RS02720	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RD12_RS02725	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RD12_RS02735	COG0356	it plays a direct role in the translocation of protons across the membrane
RD12_RS02760	COG1024	Enoyl-CoA hydratase
RD12_RS02765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RD12_RS02770	COG3634	alkyl hydroperoxide reductase activity
RD12_RS02780	COG0037	tRNA processing
RD12_RS02790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RD12_RS02795	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RD12_RS02800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RD12_RS02805	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
RD12_RS02810	COG2967	ApaG domain
RD12_RS02815	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RD12_RS02820	COG0546	phosphoglycolate phosphatase activity
RD12_RS02830	COG0512	Glutamine amidotransferase of anthranilate synthase
RD12_RS02835	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RD12_RS02840	COG0134	indole-3-glycerol-phosphate synthase activity
RD12_RS02865	COG1960	acyl-CoA dehydrogenase activity
RD12_RS02870	COG0583	DNA-binding transcription factor activity
RD12_RS02885	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RD12_RS02890	COG0259	pyridoxamine-phosphate oxidase activity
RD12_RS02900	COG2814	Major facilitator Superfamily
RD12_RS02905	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RD12_RS02910	COG2188	Transcriptional regulator
RD12_RS02915	COG0318	PFAM AMP-dependent synthetase and ligase
RD12_RS02935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RD12_RS02945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RD12_RS02960	COG1215	transferase activity, transferring glycosyl groups
RD12_RS02970	COG0601	transmembrane transport
RD12_RS02980	COG0488	(ABC) transporter
RD12_RS03000	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
RD12_RS03005	COG2894	cell division
RD12_RS03010	COG0850	regulation of cytokinetic process
RD12_RS03015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RD12_RS03020	COG1271	oxidase subunit
RD12_RS03055	COG2979	Protein of unknown function (DUF533)
RD12_RS03075	COG1388	LysM domain
RD12_RS03075	COG0741	lytic transglycosylase activity
RD12_RS03080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RD12_RS03085	COG2226	methyltransferase
RD12_RS03090	COG0328	RNA-DNA hybrid ribonuclease activity
RD12_RS03135	COG2030	dehydratase
RD12_RS03140	COG0183	Belongs to the thiolase family
RD12_RS03185	COG1960	acyl-CoA dehydrogenase activity
RD12_RS03200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD12_RS03205	COG1028	Short-chain dehydrogenase reductase Sdr
RD12_RS03220	COG2718	Belongs to the UPF0229 family
RD12_RS03225	COG2719	SpoVR family
RD12_RS03250	COG2188	Transcriptional regulator
RD12_RS03265	COG0633	Ferredoxin
RD12_RS03275	COG0829	nickel cation binding
RD12_RS03280	COG0831	urea catabolic process
RD12_RS03290	COG0832	Belongs to the urease beta subunit family
RD12_RS03295	COG0804	urea catabolic process
RD12_RS03305	COG0830	nickel cation binding
RD12_RS03310	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RD12_RS03330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD12_RS03335	COG0601	transmembrane transport
RD12_RS03340	COG0747	negative chemotaxis
RD12_RS03350	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RD12_RS03355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RD12_RS03365	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RD12_RS03375	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
RD12_RS03380	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RD12_RS03385	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
RD12_RS03400	COG0438	transferase activity, transferring glycosyl groups
RD12_RS03415	COG0438	transferase activity, transferring glycosyl groups
RD12_RS03420	COG0438	transferase activity, transferring glycosyl groups
RD12_RS03425	COG0166	Belongs to the GPI family
RD12_RS03440	COG0277	FAD linked oxidase domain protein
RD12_RS03445	COG0745	RESPONSE REGULATOR receiver
RD12_RS03450	COG0642	Histidine kinase
RD12_RS03455	COG1368	sulfuric ester hydrolase activity
RD12_RS03465	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
RD12_RS03490	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RD12_RS03500	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
RD12_RS03505	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RD12_RS03515	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RD12_RS03520	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RD12_RS03525	COG0193	aminoacyl-tRNA hydrolase activity
RD12_RS03535	COG0012	GTP binding
RD12_RS03540	COG0582	viral genome integration into host DNA
RD12_RS03560	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RD12_RS03605	COG0745	RESPONSE REGULATOR receiver
RD12_RS03620	COG1309	transcriptional regulator
RD12_RS03645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD12_RS03655	COG0405	Gamma-glutamyltransferase
RD12_RS03670	COG1280	lysine exporter protein (LysE YggA)
RD12_RS03730	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
RD12_RS03735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RD12_RS03745	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RD12_RS03750	COG0513	Belongs to the DEAD box helicase family
RD12_RS03760	COG0617	tRNA 3'-terminal CCA addition
RD12_RS03775	COG0477	Major facilitator Superfamily
RD12_RS03785	COG0583	DNA-binding transcription factor activity
RD12_RS03800	COG1950	PFAM Membrane protein of
RD12_RS03805	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
RD12_RS03820	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RD12_RS03830	COG1560	Kdo2-lipid A biosynthetic process
RD12_RS03835	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RD12_RS03845	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
RD12_RS03855	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
RD12_RS03865	COG0803	Belongs to the bacterial solute-binding protein 9 family
RD12_RS03885	COG0735	belongs to the Fur family
RD12_RS03890	COG0523	cobalamin synthesis protein
RD12_RS03900	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
RD12_RS03905	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
RD12_RS03915	COG2096	Adenosyltransferase
RD12_RS03925	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RD12_RS03930	COG2084	Dehydrogenase
RD12_RS03980	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RD12_RS03985	COG0129	dihydroxy-acid dehydratase activity
RD12_RS03990	COG4654	Cytochrome c, class I
RD12_RS03995	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RD12_RS04045	COG1473	amidohydrolase
RD12_RS04050	COG0418	dihydroorotase activity
RD12_RS04055	COG0488	(ABC) transporter
RD12_RS04065	COG2001	Belongs to the MraZ family
RD12_RS04070	COG0275	rRNA processing
RD12_RS04075	COG3116	cell division
RD12_RS04085	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RD12_RS04090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RD12_RS04095	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RD12_RS04105	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RD12_RS04110	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RD12_RS04115	COG1181	Belongs to the D-alanine--D-alanine ligase family
RD12_RS04120	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RD12_RS04130	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RD12_RS04135	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
RD12_RS04145	COG0739	heme binding
RD12_RS04150	COG0653	protein targeting
RD12_RS04170	COG1028	Short-chain dehydrogenase reductase Sdr
RD12_RS04175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD12_RS04180	COG1522	sequence-specific DNA binding
RD12_RS04200	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RD12_RS04210	COG0557	exoribonuclease II activity
RD12_RS04215	COG3150	esterase
RD12_RS04220	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RD12_RS04225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RD12_RS04230	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RD12_RS04235	COG0511	ligase activity, forming carbon-carbon bonds
RD12_RS04240	COG0439	Biotin carboxylase
RD12_RS04245	COG2264	protein methyltransferase activity
RD12_RS04255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RD12_RS04280	COG1696	Membrane protein involved in D-alanine export
RD12_RS04285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RD12_RS04320	COG1522	sequence-specific DNA binding
RD12_RS04335	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RD12_RS04340	COG1042	CoA-binding domain protein
RD12_RS04340	COG0045	succinate-CoA ligase (ADP-forming) activity
RD12_RS04340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RD12_RS04350	COG1802	Transcriptional regulator
RD12_RS04355	COG3069	C4-dicarboxylate transmembrane transporter activity
RD12_RS04360	COG0513	Belongs to the DEAD box helicase family
RD12_RS04365	COG0346	lactoylglutathione lyase activity
RD12_RS04370	COG1335	isochorismatase
RD12_RS04375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD12_RS04380	COG1116	anion transmembrane transporter activity
RD12_RS04395	COG3028	Belongs to the UPF0307 family
RD12_RS04400	COG0312	modulator of DNA gyrase
RD12_RS04405	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD12_RS04410	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RD12_RS04415	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RD12_RS04420	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RD12_RS04430	COG0316	Belongs to the HesB IscA family
RD12_RS04435	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
RD12_RS04455	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RD12_RS04465	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RD12_RS04470	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RD12_RS04485	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RD12_RS04485	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RD12_RS04515	COG0583	DNA-binding transcription factor activity
RD12_RS04520	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD12_RS04555	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
RD12_RS04565	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RD12_RS04570	COG1845	cytochrome c oxidase, subunit III
RD12_RS04575	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RD12_RS04580	COG0640	Transcriptional regulator
RD12_RS04600	COG3220	belongs to the UPF0276 family
RD12_RS04645	COG1666	GTP binding
RD12_RS04680	COG0312	modulator of DNA gyrase
RD12_RS04685	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RD12_RS04690	COG3210	domain, Protein
RD12_RS04690	COG3064	Membrane
RD12_RS04690	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
RD12_RS04690	COG3064	Membrane
RD12_RS04690	COG3210	domain, Protein
RD12_RS04690	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
RD12_RS04695	COG0277	FAD linked oxidase domain protein
RD12_RS04700	COG0277	FAD linked oxidase domain protein
RD12_RS04705	COG0277	FAD linked oxidase domain protein
RD12_RS04710	COG0247	lactate metabolic process
RD12_RS04715	COG2819	hydrolase of the alpha beta superfamily
RD12_RS04750	COG0583	DNA-binding transcription factor activity
RD12_RS04755	COG0482	sulfurtransferase activity
RD12_RS04760	COG0730	response to heat
RD12_RS04765	COG0625	glutathione transferase activity
RD12_RS04770	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RD12_RS04775	COG3909	cytochrome
RD12_RS04815	COG0154	amidase activity
RD12_RS04820	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD12_RS04825	COG1024	Enoyl-CoA hydratase
RD12_RS04840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD12_RS04855	COG1028	Short-chain dehydrogenase reductase Sdr
RD12_RS04860	COG1414	Transcriptional regulator
RD12_RS04870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RD12_RS04875	COG0251	oxidation-reduction process
RD12_RS04880	COG0559	Belongs to the binding-protein-dependent transport system permease family
RD12_RS04900	COG1902	pentaerythritol trinitrate reductase activity
RD12_RS04915	COG0583	DNA-binding transcription factor activity
RD12_RS04925	COG0590	tRNA wobble adenosine to inosine editing
RD12_RS04930	COG2807	transmembrane transport
RD12_RS04950	COG0154	amidase activity
RD12_RS04955	COG0307	riboflavin synthase, alpha
RD12_RS04960	COG3181	Tripartite tricarboxylate transporter family receptor
RD12_RS04965	COG1522	sequence-specific DNA binding
RD12_RS04975	COG0318	PFAM AMP-dependent synthetase and ligase
RD12_RS04985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD12_RS05005	COG1063	alcohol dehydrogenase
RD12_RS05035	COG1418	mRNA catabolic process
RD12_RS05040	COG1448	Aminotransferase
RD12_RS05045	COG0583	DNA-binding transcription factor activity
RD12_RS05055	COG0477	Major facilitator Superfamily
RD12_RS05060	COG1028	Short-chain dehydrogenase reductase Sdr
RD12_RS05075	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RD12_RS05080	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
RD12_RS05085	COG0583	DNA-binding transcription factor activity
RD12_RS05125	COG1028	Short-chain dehydrogenase reductase Sdr
RD12_RS05130	COG1309	transcriptional regulator
RD12_RS05140	COG2982	Protein involved in outer membrane biogenesis
RD12_RS05145	COG2818	Glycosylase
RD12_RS05165	COG1653	transport
RD12_RS05175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RD12_RS05180	COG3842	ATPase activity
RD12_RS05185	COG0395	ABC-type sugar transport system, permease component
RD12_RS05190	COG1175	transmembrane transport
RD12_RS05215	COG3181	Tripartite tricarboxylate transporter family receptor
RD12_RS05220	COG2186	Transcriptional regulator
RD12_RS05245	COG1454	alcohol dehydrogenase
RD12_RS05265	COG2011	ABC-type metal ion transport system permease component
RD12_RS05270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RD12_RS05275	COG1501	Belongs to the glycosyl hydrolase 31 family
RD12_RS05295	COG0318	PFAM AMP-dependent synthetase and ligase
RD12_RS05300	COG1473	amidohydrolase
RD12_RS05310	COG2855	membrane
RD12_RS05320	COG2239	Acts as a magnesium transporter
RD12_RS05340	COG3181	Tripartite tricarboxylate transporter family receptor
RD12_RS05350	COG1722	exodeoxyribonuclease VII activity
RD12_RS05355	COG0142	geranyltranstransferase activity
RD12_RS05360	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RD12_RS05365	COG1469	GTP cyclohydrolase I activity
RD12_RS05370	COG0360	Binds together with S18 to 16S ribosomal RNA
RD12_RS05375	COG2965	DNA replication, synthesis of RNA primer
RD12_RS05380	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RD12_RS05385	COG0359	binds to the 23S rRNA
RD12_RS05395	COG0305	Participates in initiation and elongation during chromosome replication
RD12_RS05405	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RD12_RS05410	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
RD12_RS05415	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RD12_RS05420	COG3737	Protein of unknown function (DUF498/DUF598)
RD12_RS05425	COG0436	Aminotransferase
RD12_RS05450	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RD12_RS05480	COG0268	Binds directly to 16S ribosomal RNA
RD12_RS05490	COG0728	peptidoglycan biosynthetic process
RD12_RS05500	COG0563	adenylate kinase activity
RD12_RS05505	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
RD12_RS05510	COG2835	tetraacyldisaccharide 4'-kinase activity
RD12_RS05515	COG1663	tetraacyldisaccharide 4'-kinase activity
RD12_RS05520	COG0848	biopolymer transport protein
RD12_RS05525	COG0811	peptide transport
RD12_RS05535	COG1570	exodeoxyribonuclease VII activity
RD12_RS05540	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RD12_RS05545	COG0038	chloride channel
RD12_RS05550	COG0183	Belongs to the thiolase family
RD12_RS05560	COG1278	Cold shock
RD12_RS05565	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RD12_RS05575	COG4953	penicillin-binding protein 1C
RD12_RS05580	COG0542	response to heat
RD12_RS05585	COG2995	paraquat-inducible protein a
RD12_RS05590	COG3008	intermembrane lipid transfer
RD12_RS05590	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RD12_RS05600	COG0506	proline dehydrogenase activity
RD12_RS05600	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RD12_RS05600	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RD12_RS05635	COG2271	Major facilitator Superfamily
RD12_RS05640	COG1309	transcriptional regulator
RD12_RS05650	COG3468	outer membrane autotransporter barrel domain protein
RD12_RS05680	COG0477	Major facilitator Superfamily
RD12_RS05690	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RD12_RS05695	COG1845	cytochrome c oxidase, subunit III
RD12_RS05700	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RD12_RS05710	COG1028	Short-chain dehydrogenase reductase Sdr
RD12_RS05730	COG0789	Transcriptional regulator
RD12_RS05755	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RD12_RS05760	COG0697	spore germination
RD12_RS05770	COG0678	peroxiredoxin activity
RD12_RS05780	COG0412	Dienelactone hydrolase
RD12_RS05790	COG0315	cyclic pyranopterin monophosphate synthase activity
RD12_RS05805	COG0521	Mo-molybdopterin cofactor biosynthetic process
RD12_RS05810	COG0303	'Molybdopterin
RD12_RS05815	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RD12_RS05835	COG0165	Argininosuccinate lyase
RD12_RS05840	COG0668	transmembrane transport
RD12_RS05885	COG0747	negative chemotaxis
RD12_RS05890	COG0601	transmembrane transport
RD12_RS05895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD12_RS05900	COG1162	GTPase activity
RD12_RS05905	COG0501	Belongs to the peptidase M48B family
RD12_RS05910	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
RD12_RS05920	COG3327	negative regulation of DNA-templated transcription, initiation
RD12_RS05925	COG3396	Phenylacetate-CoA oxygenase
RD12_RS05930	COG3460	Phenylacetate-CoA oxygenase
RD12_RS05935	COG3396	Phenylacetate-CoA oxygenase
RD12_RS05940	COG2151	metal-sulfur cluster biosynthetic enzyme
RD12_RS05945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RD12_RS05955	COG1012	belongs to the aldehyde dehydrogenase family
RD12_RS05960	COG1024	Enoyl-CoA hydratase
RD12_RS05965	COG2050	protein possibly involved in aromatic compounds catabolism
RD12_RS05975	COG3539	Fimbrial protein
RD12_RS05990	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD12_RS05995	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD12_RS05995	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD12_RS06000	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD12_RS06005	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RD12_RS06005	COG0047	phosphoribosylformylglycinamidine synthase activity
RD12_RS06010	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
RD12_RS06010	COG3210	domain, Protein
RD12_RS06010	COG3064	Membrane
RD12_RS06035	COG0235	Class ii aldolase
RD12_RS06040	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD12_RS06045	COG0720	synthase
RD12_RS06050	COG0602	queuosine metabolic process
RD12_RS06075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RD12_RS06110	COG3181	Tripartite tricarboxylate transporter family receptor
RD12_RS06140	COG3842	ATPase activity
RD12_RS06150	COG0395	ABC-type sugar transport system, permease component
RD12_RS06180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD12_RS06185	COG0420	3'-5' exonuclease activity
RD12_RS06210	COG2197	response regulator
RD12_RS06235	COG0519	Catalyzes the synthesis of GMP from XMP
RD12_RS06235	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RD12_RS06245	COG3550	peptidyl-serine autophosphorylation
RD12_RS06255	COG0477	Major facilitator Superfamily
RD12_RS06270	COG1228	amidohydrolase
RD12_RS06280	COG1116	anion transmembrane transporter activity
RD12_RS06285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD12_RS06320	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
RD12_RS06335	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
RD12_RS06365	COG2814	Major facilitator Superfamily
RD12_RS06380	COG1280	lysine exporter protein (LysE YggA)
RD12_RS06395	COG0747	negative chemotaxis
RD12_RS06400	COG0601	transmembrane transport
RD12_RS06405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD12_RS06410	COG4172	Belongs to the ABC transporter superfamily
RD12_RS06415	COG1609	Transcriptional regulator
RD12_RS06440	COG0586	Pfam SNARE associated Golgi protein
RD12_RS06450	COG0500	methyltransferase
RD12_RS06460	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
RD12_RS06470	COG1653	transport
RD12_RS06475	COG1175	transmembrane transport
RD12_RS06480	COG0395	ABC-type sugar transport system, permease component
RD12_RS06485	COG3842	ATPase activity
RD12_RS06510	COG2363	Small membrane protein
RD12_RS06525	COG1464	Belongs to the NlpA lipoprotein family
RD12_RS06535	COG0688	phosphatidylethanolamine metabolic process
RD12_RS06550	COG0095	Lipoate-protein ligase
RD12_RS06565	COG0625	glutathione transferase activity
RD12_RS06570	COG0386	Belongs to the glutathione peroxidase family
RD12_RS06590	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD12_RS06620	COG2259	Doxx family
RD12_RS06635	COG0667	Aldo Keto reductase
RD12_RS06665	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
RD12_RS06680	COG1640	4-alpha-glucanotransferase
RD12_RS06690	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RD12_RS06700	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RD12_RS06740	COG0392	lysyltransferase activity
RD12_RS06755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RD12_RS06760	COG3568	Endonuclease Exonuclease Phosphatase
RD12_RS06765	COG1695	Transcriptional regulator
RD12_RS06785	COG0583	DNA-binding transcription factor activity
RD12_RS06800	COG1802	Transcriptional regulator
RD12_RS06810	COG3181	Tripartite tricarboxylate transporter family receptor
RD12_RS06820	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD12_RS06835	COG0066	3-isopropylmalate dehydratase activity
RD12_RS06845	COG3181	Tripartite tricarboxylate transporter family receptor
RD12_RS06850	COG4948	Mandelate Racemase Muconate Lactonizing
RD12_RS06865	COG1126	abc transporter atp-binding protein
RD12_RS06870	COG0765	amino acid transport
RD12_RS06875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD12_RS06915	COG1815	bacterial-type flagellum-dependent cell motility
RD12_RS06920	COG1558	bacterial-type flagellum-dependent cell motility
RD12_RS06930	COG1749	Flagellar hook protein flgE
RD12_RS06945	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
RD12_RS06950	COG1706	bacterial-type flagellum-dependent cell motility
RD12_RS06960	COG1256	bacterial-type flagellum assembly
RD12_RS06970	COG0840	transmembrane signaling receptor activity
RD12_RS06975	COG0840	transmembrane signaling receptor activity
RD12_RS06980	COG0840	transmembrane signaling receptor activity
RD12_RS07000	COG1338	Plays a role in the flagellum-specific transport system
RD12_RS07020	COG1580	Controls the rotational direction of flagella during chemotaxis
RD12_RS07045	COG1157	protein secretion by the type III secretion system
RD12_RS07055	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RD12_RS07065	COG1677	Flagellar hook-basal body complex protein FliE
RD12_RS07075	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RD12_RS07115	COG0285	dihydrofolate synthase activity
RD12_RS07145	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
RD12_RS07150	COG0024	Methionine aminopeptidase
RD12_RS07155	COG0052	Belongs to the universal ribosomal protein uS2 family
RD12_RS07160	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RD12_RS07165	COG0528	UMP kinase activity
RD12_RS07170	COG0233	cytoplasmic translational termination
RD12_RS07175	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RD12_RS07185	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RD12_RS07190	COG0750	zinc metalloprotease
RD12_RS07195	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RD12_RS07200	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
RD12_RS07205	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RD12_RS07210	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RD12_RS07220	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RD12_RS07225	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RD12_RS07230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RD12_RS07235	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
RD12_RS07245	COG0519	Catalyzes the synthesis of GMP from XMP
RD12_RS07245	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RD12_RS07260	COG0330	HflC and HflK could
RD12_RS07265	COG3706	GGDEF domain
RD12_RS07270	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RD12_RS07280	COG2867	negative regulation of translational initiation
RD12_RS07290	COG1960	acyl-CoA dehydrogenase activity
RD12_RS07295	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
RD12_RS07325	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RD12_RS07330	COG0505	Belongs to the CarA family
RD12_RS07335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RD12_RS07345	COG0406	alpha-ribazole phosphatase activity
RD12_RS07355	COG3842	ATPase activity
RD12_RS07375	COG5001	Diguanylate cyclase
RD12_RS07380	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RD12_RS07390	COG1763	Mo-molybdopterin cofactor biosynthetic process
RD12_RS07395	COG0303	'Molybdopterin
RD12_RS07400	COG0746	molybdenum cofactor guanylyltransferase activity
RD12_RS07405	COG0489	protein tyrosine kinase activity
RD12_RS07435	COG0243	molybdopterin cofactor binding
RD12_RS07435	COG3383	formate dehydrogenase (NAD+) activity
RD12_RS07440	COG0437	4 iron, 4 sulfur cluster binding
RD12_RS07470	COG1122	ATPase activity
RD12_RS07480	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RD12_RS07485	COG0066	3-isopropylmalate dehydratase activity
RD12_RS07490	COG0473	3-isopropylmalate dehydrogenase activity
RD12_RS07495	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RD12_RS07505	COG0101	tRNA pseudouridine synthase activity
RD12_RS07510	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD12_RS07525	COG0135	phosphoribosylanthranilate isomerase activity
RD12_RS07540	COG3022	response to hydroperoxide
RD12_RS07550	COG1289	transmembrane transporter activity
RD12_RS07570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RD12_RS07580	COG2197	response regulator
RD12_RS07585	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RD12_RS07590	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RD12_RS07595	COG0189	ligase activity
RD12_RS07605	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RD12_RS07610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RD12_RS07620	COG2423	ornithine cyclodeaminase activity
RD12_RS07630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD12_RS07635	COG0765	amino acid transport
RD12_RS07640	COG0765	amino acid transport
RD12_RS07645	COG1126	abc transporter atp-binding protein
RD12_RS07700	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RD12_RS07710	COG2944	sequence-specific DNA binding
RD12_RS07715	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
RD12_RS07720	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RD12_RS07725	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RD12_RS07730	COG0009	L-threonylcarbamoyladenylate synthase
RD12_RS07735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD12_RS07740	COG1414	Transcriptional regulator
RD12_RS07755	COG0765	amino acid transport
RD12_RS07760	COG1126	abc transporter atp-binding protein
RD12_RS07765	COG0028	Belongs to the TPP enzyme family
RD12_RS07780	COG0028	Belongs to the TPP enzyme family
RD12_RS07785	COG0583	DNA-binding transcription factor activity
RD12_RS07790	COG4974	Belongs to the 'phage' integrase family
RD12_RS07795	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RD12_RS07800	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
RD12_RS07815	COG1686	Belongs to the peptidase S11 family
RD12_RS07825	COG2814	Major facilitator Superfamily
RD12_RS07835	COG1074	ATP-dependent DNA helicase activity
RD12_RS07845	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RD12_RS07850	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RD12_RS07855	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RD12_RS07875	COG2321	neutral zinc metallopeptidase
RD12_RS07880	COG0009	L-threonylcarbamoyladenylate synthase
RD12_RS07920	COG3360	Dodecin
RD12_RS07925	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RD12_RS07930	COG2850	peptidyl-arginine hydroxylation
RD12_RS07935	COG3539	Fimbrial protein
RD12_RS07940	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
RD12_RS07945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RD12_RS07950	COG1994	Peptidase M50
RD12_RS07960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD12_RS07965	COG0765	amino acid transport
RD12_RS07970	COG1126	abc transporter atp-binding protein
RD12_RS07975	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RD12_RS07980	COG1758	RNA polymerase activity
RD12_RS07985	COG0194	GDP metabolic process
RD12_RS07990	COG3258	Cytochrome c
RD12_RS07995	COG2863	cytochrome
RD12_RS08000	COG1028	Short-chain dehydrogenase reductase Sdr
RD12_RS08005	COG0791	NLP P60 protein
RD12_RS08010	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RD12_RS08030	COG1561	YicC-like family, N-terminal region
RD12_RS08035	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RD12_RS08050	COG2200	EAL domain
RD12_RS08050	COG2199	diguanylate cyclase activity
RD12_RS08055	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RD12_RS08065	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RD12_RS08070	COG0174	glutamine synthetase
RD12_RS08080	COG2204	response regulator
RD12_RS08085	COG0583	DNA-binding transcription factor activity
RD12_RS08090	COG1741	Belongs to the pirin family
RD12_RS08095	COG1741	Belongs to the pirin family
RD12_RS08105	COG3842	ATPase activity
RD12_RS08110	COG1178	ABC-type Fe3 transport system permease component
RD12_RS08115	COG1840	ABC-type Fe3 transport system, periplasmic component
RD12_RS08125	COG0583	DNA-binding transcription factor activity
RD12_RS08135	COG0656	L-ascorbic acid biosynthetic process
RD12_RS08150	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RD12_RS08155	COG0583	DNA-binding transcription factor activity
RD12_RS08170	COG0783	Belongs to the Dps family
RD12_RS08205	COG0438	transferase activity, transferring glycosyl groups
RD12_RS08220	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
RD12_RS08245	COG0300	oxidoreductase activity
RD12_RS08290	COG0861	Integral membrane protein TerC family
RD12_RS08295	COG1028	Short-chain dehydrogenase reductase Sdr
RD12_RS08315	COG0714	Associated with various cellular activities
RD12_RS08345	COG3119	arylsulfatase activity
RD12_RS08370	COG2197	response regulator
RD12_RS08380	COG2944	sequence-specific DNA binding
RD12_RS08385	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
RD12_RS08390	COG0625	glutathione transferase activity
RD12_RS08420	COG0179	Fumarylacetoacetate (FAA) hydrolase
RD12_RS08425	COG1028	Short-chain dehydrogenase reductase Sdr
RD12_RS08470	COG0431	NADPH-dependent FMN reductase
RD12_RS08500	COG1028	Short-chain dehydrogenase reductase Sdr
RD12_RS08505	COG0583	DNA-binding transcription factor activity
RD12_RS08520	COG3181	Tripartite tricarboxylate transporter family receptor
RD12_RS08525	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RD12_RS08525	COG2111	Na H antiporter
RD12_RS08530	COG1006	Multisubunit Na H antiporter MnhC subunit
RD12_RS08535	COG0651	ATP synthesis coupled electron transport
RD12_RS08540	COG1863	multisubunit Na H antiporter MnhE subunit
RD12_RS08545	COG2212	antiporter activity
RD12_RS08570	COG0590	tRNA wobble adenosine to inosine editing
RD12_RS08575	COG1619	proteins homologs of microcin C7 resistance protein MccF
RD12_RS08580	COG1024	Enoyl-CoA hydratase
RD12_RS08595	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD12_RS08600	COG0488	(ABC) transporter
RD12_RS08635	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RD12_RS08635	COG1017	nitric oxide dioxygenase activity
RD12_RS08640	COG1959	2 iron, 2 sulfur cluster binding
RD12_RS08645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD12_RS08665	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RD12_RS08670	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RD12_RS08675	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RD12_RS08680	COG0084	hydrolase, TatD family'
RD12_RS08695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD12_RS08705	COG1126	abc transporter atp-binding protein
RD12_RS08710	COG0010	Belongs to the arginase family
RD12_RS08715	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RD12_RS08720	COG1012	belongs to the aldehyde dehydrogenase family
RD12_RS08730	COG0028	Belongs to the TPP enzyme family
RD12_RS08740	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD12_RS08740	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD12_RS08750	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD12_RS08765	COG3189	MarR family transcriptional regulator
RD12_RS08790	COG4336	lyase activity
RD12_RS08800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD12_RS08800	COG2205	protein histidine kinase activity
RD12_RS08805	COG2197	response regulator
RD12_RS08810	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
RD12_RS08810	COG3064	Membrane
RD12_RS08810	COG3210	domain, Protein
RD12_RS08820	COG3121	Chaperone
RD12_RS08825	COG3188	usher protein
RD12_RS08830	COG3539	Fimbrial protein
RD12_RS08835	COG2831	hemolysin activation secretion protein
RD12_RS08850	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD12_RS08875	COG0583	DNA-binding transcription factor activity
RD12_RS08900	COG0668	transmembrane transport
RD12_RS08920	COG0483	inositol monophosphate 1-phosphatase activity
RD12_RS08925	COG1253	flavin adenine dinucleotide binding
RD12_RS08930	COG1968	undecaprenyl-diphosphatase activity
RD12_RS08935	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RD12_RS08950	COG0215	cysteine-tRNA ligase activity
RD12_RS08960	COG0825	malonyl-CoA metabolic process
RD12_RS08970	COG0037	tRNA processing
RD12_RS08975	COG0527	aspartate kinase activity
RD12_RS09000	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD12_RS09005	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD12_RS09005	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD12_RS09020	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RD12_RS09025	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
RD12_RS09030	COG1028	Short-chain dehydrogenase reductase Sdr
RD12_RS09040	COG0583	DNA-binding transcription factor activity
RD12_RS09070	COG3842	ATPase activity
RD12_RS09080	COG1902	pentaerythritol trinitrate reductase activity
RD12_RS09080	COG0446	pyridine nucleotide-disulphide oxidoreductase
RD12_RS09085	COG1414	Transcriptional regulator
RD12_RS09090	COG1832	CoA-binding protein
RD12_RS09100	COG0251	oxidation-reduction process
RD12_RS09125	COG1902	pentaerythritol trinitrate reductase activity
RD12_RS09135	COG1215	transferase activity, transferring glycosyl groups
RD12_RS09140	COG1649	PFAM Uncharacterised BCR, COG1649
RD12_RS09140	COG0726	polysaccharide deacetylase
RD12_RS09160	COG1846	Transcriptional regulator
RD12_RS09180	COG0166	Belongs to the GPI family
RD12_RS09185	COG1045	serine acetyltransferase
RD12_RS09195	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RD12_RS09200	COG0483	inositol monophosphate 1-phosphatase activity
RD12_RS09205	COG1012	belongs to the aldehyde dehydrogenase family
RD12_RS09210	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RD12_RS09225	COG0210	DNA helicase
RD12_RS09230	COG0598	Magnesium transport protein CorA
RD12_RS09240	COG0747	negative chemotaxis
RD12_RS09245	COG0601	transmembrane transport
RD12_RS09250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD12_RS09255	COG4172	Belongs to the ABC transporter superfamily
RD12_RS09260	COG1846	Transcriptional regulator
RD12_RS09310	COG4964	Belongs to the GSP D family
RD12_RS09350	COG2204	response regulator
RD12_RS09365	COG1595	DNA-templated transcription, initiation
RD12_RS09375	COG3474	cytochrome
RD12_RS09380	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RD12_RS09395	COG3384	dioxygenase
RD12_RS09400	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RD12_RS09425	COG2885	chlorophyll binding
RD12_RS09460	COG0697	spore germination
RD12_RS09465	COG0730	response to heat
RD12_RS09480	COG0583	DNA-binding transcription factor activity
RD12_RS09485	COG0427	acetyl-CoA hydrolase
RD12_RS09540	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD12_RS09545	COG0154	amidase activity
RD12_RS09555	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RD12_RS09570	COG0495	leucyl-tRNA aminoacylation
RD12_RS09575	COG2814	Major facilitator Superfamily
RD12_RS09605	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RD12_RS09610	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RD12_RS09615	COG2814	Major facilitator Superfamily
RD12_RS09620	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RD12_RS09635	COG4176	ABC-type proline glycine betaine transport system permease component
RD12_RS09645	COG1942	4-Oxalocrotonate Tautomerase
RD12_RS09650	COG0183	Belongs to the thiolase family
RD12_RS09660	COG1802	Transcriptional regulator
RD12_RS09670	COG1024	Enoyl-CoA hydratase
RD12_RS09685	COG2032	superoxide dismutase activity
RD12_RS09700	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RD12_RS09725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RD12_RS09730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RD12_RS09740	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
RD12_RS09745	COG0736	holo-[acyl-carrier-protein] synthase activity
RD12_RS09750	COG1472	Belongs to the glycosyl hydrolase 3 family
RD12_RS09755	COG0322	excinuclease ABC activity
RD12_RS09760	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RD12_RS09775	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RD12_RS09775	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RD12_RS09780	COG2224	Isocitrate lyase
RD12_RS09800	COG0559	Belongs to the binding-protein-dependent transport system permease family
RD12_RS09810	COG4638	Rieske (2fe-2S)
RD12_RS09820	COG1024	Enoyl-CoA hydratase
RD12_RS09830	COG0633	Ferredoxin
RD12_RS09835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD12_RS09850	COG0183	Belongs to the thiolase family
RD12_RS09860	COG4692	amylo-alpha-1,6-glucosidase activity
RD12_RS09865	COG0583	DNA-binding transcription factor activity
RD12_RS09890	COG2346	COG2346, Truncated hemoglobins
RD12_RS10020	COG2207	Transcriptional regulator
RD12_RS10065	COG1132	(ABC) transporter
RD12_RS10090	COG0659	secondary active sulfate transmembrane transporter activity
RD12_RS10120	COG2169	Transcriptional regulator
RD12_RS10125	COG5507	3-demethylubiquinone-9 3-methyltransferase
RD12_RS10130	COG0384	phenazine biosynthesis protein PhzF
RD12_RS10135	COG0583	DNA-binding transcription factor activity
RD12_RS10140	COG2733	membrane
RD12_RS10155	COG1012	belongs to the aldehyde dehydrogenase family
RD12_RS10160	COG3284	Transcriptional regulator
RD12_RS10175	COG1346	cytolysis
RD12_RS10180	COG1380	Effector of murein hydrolase LrgA
RD12_RS10185	COG4106	trans-aconitate 2-methyltransferase activity
RD12_RS10185	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RD12_RS10195	COG0156	8-amino-7-oxononanoate synthase activity
RD12_RS10265	COG1131	(ABC) transporter
RD12_RS10270	COG0842	Transport permease protein
RD12_RS10275	COG0628	permease
RD12_RS10300	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RD12_RS10310	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RD12_RS10315	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
RD12_RS10320	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RD12_RS10325	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
RD12_RS10330	COG0330	HflC and HflK could
RD12_RS10335	COG0330	HflC and HflK could
RD12_RS10340	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RD12_RS10345	COG1923	regulation of RNA biosynthetic process
RD12_RS10350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RD12_RS10355	COG1160	GTP binding
RD12_RS10360	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RD12_RS10365	COG2976	Protein conserved in bacteria
RD12_RS10370	COG0124	histidyl-tRNA synthetase
RD12_RS10375	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RD12_RS10385	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RD12_RS10390	COG0105	UTP biosynthetic process
RD12_RS10395	COG0525	valine-tRNA ligase activity
RD12_RS10410	COG0642	Histidine kinase
RD12_RS10430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RD12_RS10435	COG0336	Belongs to the RNA methyltransferase TrmD family
RD12_RS10440	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RD12_RS10445	COG0228	four-way junction DNA binding
RD12_RS10455	COG0425	Belongs to the sulfur carrier protein TusA family
RD12_RS10460	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RD12_RS10505	COG0154	amidase activity
RD12_RS10510	COG4172	Belongs to the ABC transporter superfamily
RD12_RS10515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD12_RS10520	COG0601	transmembrane transport
RD12_RS10525	COG0747	negative chemotaxis
RD12_RS10550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD12_RS10560	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
RD12_RS10575	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RD12_RS10580	COG3395	kinase activity
RD12_RS10595	COG1024	Enoyl-CoA hydratase
RD12_RS10615	COG0633	Ferredoxin
RD12_RS10620	COG0443	Heat shock 70 kDa protein
RD12_RS10625	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RD12_RS10630	COG0316	Belongs to the HesB IscA family
RD12_RS10635	COG0822	iron-sulfur transferase activity
RD12_RS10640	COG1104	cysteine desulfurase activity
RD12_RS10650	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RD12_RS10655	COG0556	nucleotide-excision repair
RD12_RS10665	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RD12_RS10670	COG3468	outer membrane autotransporter barrel domain protein
RD12_RS10695	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RD12_RS10710	COG1960	acyl-CoA dehydrogenase activity
RD12_RS10715	COG1028	Short-chain dehydrogenase reductase Sdr
RD12_RS10720	COG0183	Belongs to the thiolase family
RD12_RS10730	COG1024	Enoyl-CoA hydratase
RD12_RS10745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD12_RS10750	COG0583	DNA-binding transcription factor activity
RD12_RS10755	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RD12_RS10760	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RD12_RS10765	COG0740	serine-type endopeptidase activity
RD12_RS10770	COG0544	peptidyl-prolyl cis-trans isomerase activity
RD12_RS10780	COG1278	Cold shock
RD12_RS10790	COG1278	Cold shock
RD12_RS10825	COG2171	N-acyltransferase activity
RD12_RS10830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RD12_RS10835	COG2890	protein-(glutamine-N5) methyltransferase activity
RD12_RS10840	COG0488	(ABC) transporter
RD12_RS10845	COG4771	TonB-dependent receptor
RD12_RS10850	COG0210	DNA helicase
RD12_RS10870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RD12_RS10870	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RD12_RS10875	COG0196	riboflavin kinase activity
RD12_RS10880	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RD12_RS10885	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RD12_RS10890	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RD12_RS10900	COG1522	sequence-specific DNA binding
RD12_RS10915	COG2951	lytic endotransglycosylase activity
RD12_RS10920	COG2833	Protein of unknown function (DUF455)
RD12_RS10940	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RD12_RS10940	COG0189	ligase activity
RD12_RS10945	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RD12_RS10945	COG1181	Belongs to the D-alanine--D-alanine ligase family
RD12_RS10950	COG3237	CsbD-like
RD12_RS10960	COG2823	Periplasmic or secreted lipoprotein
RD12_RS10975	COG4181	ATPase activity
RD12_RS10985	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RD12_RS10990	COG0584	glycerophosphoryl diester phosphodiesterase
RD12_RS10995	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
RD12_RS11005	COG0678	peroxiredoxin activity
RD12_RS11005	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RD12_RS11015	COG0789	Transcriptional regulator
RD12_RS11020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RD12_RS11050	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
RD12_RS11055	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RD12_RS11065	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RD12_RS11070	COG2252	PERMEase
RD12_RS11080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RD12_RS11110	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RD12_RS11115	COG2358	TRAP transporter, solute receptor (TAXI family
RD12_RS11145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RD12_RS11150	COG1366	Belongs to the anti-sigma-factor antagonist family
RD12_RS11155	COG2172	sigma factor antagonist activity
RD12_RS11160	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RD12_RS11170	COG2770	Histidine kinase
RD12_RS11170	COG2208	phosphoserine phosphatase activity
RD12_RS11195	COG1595	DNA-templated transcription, initiation
RD12_RS11210	COG4792	protein secretion
RD12_RS11215	COG4791	protein targeting
RD12_RS11220	COG4794	Type iii secretion
RD12_RS11225	COG4790	Type iii secretion
RD12_RS11260	COG4669	(LipO)protein
RD12_RS11325	COG4789	Type iii secretion
RD12_RS11355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RD12_RS11360	COG0840	transmembrane signaling receptor activity
RD12_RS11365	COG2233	PERMEase
RD12_RS11385	COG0492	ferredoxin-NADP+ reductase activity
RD12_RS11390	COG1840	ABC-type Fe3 transport system, periplasmic component
RD12_RS11395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RD12_RS11400	COG1178	ABC-type Fe3 transport system permease component
RD12_RS11405	COG3842	ATPase activity
RD12_RS11410	COG0583	DNA-binding transcription factor activity
RD12_RS11430	COG0501	Belongs to the peptidase M48B family
RD12_RS11440	COG0697	spore germination
RD12_RS11450	COG1846	Transcriptional regulator
RD12_RS11460	COG1566	PFAM secretion protein HlyD family protein
RD12_RS11465	COG2814	Major facilitator Superfamily
RD12_RS11470	COG0473	3-isopropylmalate dehydrogenase activity
RD12_RS11480	COG0747	negative chemotaxis
RD12_RS11490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD12_RS11505	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RD12_RS11530	COG1012	belongs to the aldehyde dehydrogenase family
RD12_RS11540	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RD12_RS11545	COG1115	amino acid carrier protein
RD12_RS11550	COG0433	COG0433 Predicted ATPase
RD12_RS11555	COG0217	transcriptional regulatory protein
RD12_RS11560	COG0151	Belongs to the GarS family
RD12_RS11565	COG0408	coproporphyrinogen oxidase activity
RD12_RS11570	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RD12_RS11575	COG0799	negative regulation of ribosome biogenesis
RD12_RS11580	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RD12_RS11585	COG0424	maF-like protein
RD12_RS11590	COG3468	outer membrane autotransporter barrel domain protein
RD12_RS11630	COG1530	ribonuclease E activity
RD12_RS11635	COG0077	Prephenate dehydratase
RD12_RS11650	COG1132	(ABC) transporter
RD12_RS11655	COG0859	PFAM glycosyl transferase family 9
RD12_RS11680	COG2194	sulfuric ester hydrolase activity
RD12_RS11685	COG0438	transferase activity, transferring glycosyl groups
RD12_RS11690	COG0463	Glycosyl transferase, family 2
RD12_RS11695	COG0726	polysaccharide deacetylase
RD12_RS11700	COG0438	transferase activity, transferring glycosyl groups
RD12_RS11715	COG1643	Atp-dependent helicase
RD12_RS11720	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RD12_RS11720	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RD12_RS11725	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
RD12_RS11735	COG0704	Plays a role in the regulation of phosphate uptake
RD12_RS11740	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
RD12_RS11745	COG1960	acyl-CoA dehydrogenase activity
RD12_RS11770	COG1177	transmembrane transport
RD12_RS11775	COG1176	ABC-type spermidine putrescine transport system, permease component I
RD12_RS11780	COG3842	ATPase activity
RD12_RS11785	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RD12_RS11800	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
RD12_RS11805	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD12_RS11815	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD12_RS11815	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD12_RS11835	COG0372	Belongs to the citrate synthase family
RD12_RS11840	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
RD12_RS11845	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RD12_RS11850	COG1053	succinate dehydrogenase
RD12_RS11855	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
RD12_RS11860	COG2009	succinate dehydrogenase
RD12_RS11865	COG2188	Transcriptional regulator
RD12_RS11870	COG0039	L-malate dehydrogenase activity
RD12_RS11900	COG1981	membrane
RD12_RS11925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RD12_RS11935	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
RD12_RS11965	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
RD12_RS11970	COG0148	phosphopyruvate hydratase activity
RD12_RS11980	COG2877	3-deoxy-8-phosphooctulonate synthase activity
RD12_RS11985	COG0504	CTP synthase activity
RD12_RS12010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD12_RS12020	COG0747	negative chemotaxis
RD12_RS12025	COG4172	Belongs to the ABC transporter superfamily
RD12_RS12030	COG1446	asparaginase
RD12_RS12060	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RD12_RS12075	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
RD12_RS12080	COG0697	spore germination
RD12_RS12085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RD12_RS12095	COG3193	protein, possibly involved in utilization of glycolate and propanediol
RD12_RS12100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RD12_RS12105	COG0791	NLP P60 protein
RD12_RS12120	COG0583	DNA-binding transcription factor activity
RD12_RS12135	COG0583	DNA-binding transcription factor activity
RD12_RS12145	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RD12_RS12160	COG0670	Belongs to the BI1 family
RD12_RS12165	COG3181	Tripartite tricarboxylate transporter family receptor
RD12_RS12180	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RD12_RS12190	COG1381	Involved in DNA repair and RecF pathway recombination
RD12_RS12195	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RD12_RS12200	COG0571	ribonuclease III activity
RD12_RS12205	COG0681	Belongs to the peptidase S26 family
RD12_RS12210	COG0481	GTPase activity
RD12_RS12215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RD12_RS12240	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RD12_RS12245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RD12_RS12260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RD12_RS12265	COG0416	fatty acid biosynthetic process
RD12_RS12270	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RD12_RS12275	COG1399	metal-binding, possibly nucleic acid-binding protein
RD12_RS12280	COG0424	maF-like protein
RD12_RS12290	COG3023	N-Acetylmuramoyl-L-alanine amidase
RD12_RS12295	COG1289	transmembrane transporter activity
RD12_RS12305	COG3022	response to hydroperoxide
RD12_RS12315	COG1028	Short-chain dehydrogenase reductase Sdr
RD12_RS12330	COG3486	L-lysine 6-monooxygenase (NADPH) activity
RD12_RS12360	COG2814	Major facilitator Superfamily
RD12_RS12380	COG3706	GGDEF domain
RD12_RS12405	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RD12_RS12410	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RD12_RS12415	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
RD12_RS12420	COG1674	ftsk spoiiie
RD12_RS12425	COG0492	ferredoxin-NADP+ reductase activity
RD12_RS12430	COG1193	negative regulation of DNA recombination
RD12_RS12450	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RD12_RS12460	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
RD12_RS12465	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
RD12_RS12470	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
RD12_RS12475	COG2205	protein histidine kinase activity
RD12_RS12480	COG0745	RESPONSE REGULATOR receiver
RD12_RS12525	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RD12_RS12545	COG0612	Peptidase, M16
RD12_RS12555	COG0443	Heat shock 70 kDa protein
RD12_RS12565	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RD12_RS12575	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RD12_RS12580	COG1420	regulation of RNA biosynthetic process
RD12_RS12585	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RD12_RS12590	COG0497	DNA recombination
RD12_RS12595	COG0735	belongs to the Fur family
RD12_RS12600	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RD12_RS12605	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RD12_RS12610	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RD12_RS12645	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RD12_RS12645	COG0446	pyridine nucleotide-disulphide oxidoreductase
RD12_RS12650	COG4311	Sarcosine oxidase, delta subunit
RD12_RS12655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD12_RS12665	COG0583	DNA-binding transcription factor activity
RD12_RS12675	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RD12_RS12705	COG4964	Belongs to the GSP D family
RD12_RS12765	COG0181	hydroxymethylbilane synthase activity
RD12_RS12770	COG0861	Integral membrane protein TerC family
RD12_RS12775	COG0861	Integral membrane protein TerC family
RD12_RS12780	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RD12_RS12785	COG0045	succinate-CoA ligase (ADP-forming) activity
RD12_RS12795	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
RD12_RS12805	COG2137	regulation of response to DNA damage stimulus
RD12_RS12810	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RD12_RS12830	COG1024	Enoyl-CoA hydratase
RD12_RS12830	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD12_RS12835	COG3842	ATPase activity
RD12_RS12850	COG1028	Short-chain dehydrogenase reductase Sdr
RD12_RS12870	COG0583	DNA-binding transcription factor activity
RD12_RS12875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD12_RS12885	COG2974	May be involved in recombination
RD12_RS12890	COG0540	Belongs to the ATCase OTCase family
RD12_RS12960	COG0776	regulation of translation
RD12_RS12965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RD12_RS12965	COG0072	phenylalanine-tRNA ligase activity
RD12_RS12970	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RD12_RS12975	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RD12_RS12980	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RD12_RS12990	COG0756	dUTP diphosphatase activity
RD12_RS13000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RD12_RS13020	COG0559	Belongs to the binding-protein-dependent transport system permease family
RD12_RS13040	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RD12_RS13055	COG0697	spore germination
RD12_RS13065	COG2311	Membrane
RD12_RS13090	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RD12_RS13100	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RD12_RS13105	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RD12_RS13110	COG1760	l-serine dehydratase
RD12_RS13115	COG1283	sodium-dependent phosphate transmembrane transporter activity
RD12_RS13120	COG0412	Dienelactone hydrolase
RD12_RS13135	COG1611	Belongs to the LOG family
RD12_RS13155	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RD12_RS13160	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RD12_RS13165	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RD12_RS13170	COG0195	Participates in both transcription termination and antitermination
RD12_RS13170	COG2251	uridine kinase activity
RD12_RS13175	COG0779	Required for maturation of 30S ribosomal subunits
RD12_RS13180	COG1187	pseudouridine synthase activity
RD12_RS13185	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RD12_RS13195	COG0583	DNA-binding transcription factor activity
RD12_RS13205	COG0523	cobalamin synthesis protein
RD12_RS13225	COG0625	glutathione transferase activity
RD12_RS13230	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RD12_RS13235	COG1047	Peptidyl-prolyl cis-trans
RD12_RS13240	COG2003	Belongs to the UPF0758 family
RD12_RS13245	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
RD12_RS13250	COG3483	tryptophan 2,3-dioxygenase activity
RD12_RS13255	COG0254	rRNA binding
RD12_RS13265	COG0534	Mate efflux family protein
RD12_RS13285	COG2304	oxidoreductase activity
RD12_RS13305	COG1028	Short-chain dehydrogenase reductase Sdr
RD12_RS13310	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RD12_RS13315	COG1562	ergosterol biosynthetic process
RD12_RS13320	COG1562	ergosterol biosynthetic process
RD12_RS13325	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
RD12_RS13325	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
RD12_RS13330	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RD12_RS13340	COG0842	Transport permease protein
RD12_RS13345	COG1131	(ABC) transporter
RD12_RS13365	COG1477	protein flavinylation
RD12_RS13380	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
RD12_RS13395	COG5564	TIM-barrel signal transduction protein
RD12_RS13400	COG5441	Belongs to the UPF0261 family
RD12_RS13410	COG3468	outer membrane autotransporter barrel domain protein
RD12_RS13415	COG3468	outer membrane autotransporter barrel domain protein
RD12_RS13425	COG0542	response to heat
RD12_RS13430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RD12_RS13445	COG0494	nUDIX hydrolase
RD12_RS13450	COG3530	Putative quorum-sensing-regulated virulence factor
RD12_RS13460	COG1595	DNA-templated transcription, initiation
RD12_RS13465	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RD12_RS13500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD12_RS13505	COG0765	amino acid transport
RD12_RS13510	COG0765	amino acid transport
RD12_RS13540	COG2988	succinylglutamate desuccinylase activity
RD12_RS13565	COG3181	Tripartite tricarboxylate transporter family receptor
RD12_RS13570	COG2084	Dehydrogenase
RD12_RS13585	COG1619	proteins homologs of microcin C7 resistance protein MccF
RD12_RS13600	COG2814	Major facilitator Superfamily
RD12_RS13610	COG0583	DNA-binding transcription factor activity
RD12_RS13650	COG0672	)-iron permease
RD12_RS13665	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
RD12_RS13670	COG1028	Short-chain dehydrogenase reductase Sdr
RD12_RS13675	COG3243	poly(R)-hydroxyalkanoic acid synthase
RD12_RS13685	COG0564	pseudouridine synthase activity
RD12_RS13695	COG1199	ATP-dependent helicase activity
RD12_RS13700	COG2183	response to ionizing radiation
RD12_RS13705	COG0180	Tryptophanyl-tRNA synthetase
RD12_RS13725	COG3181	Tripartite tricarboxylate transporter family receptor
RD12_RS13735	COG0583	DNA-binding transcription factor activity
RD12_RS13740	COG1028	Short-chain dehydrogenase reductase Sdr
RD12_RS13745	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RD12_RS13750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RD12_RS13755	COG0508	dehydrogenase complex catalyzes the overall conversion of
RD12_RS13760	COG0567	Dehydrogenase, E1 component
RD12_RS13765	COG1297	OPT oligopeptide transporter protein
RD12_RS13770	COG1297	OPT oligopeptide transporter protein
RD12_RS13775	COG1522	sequence-specific DNA binding
RD12_RS13785	COG0280	phosphate acetyltransferase
RD12_RS13785	COG0281	malic enzyme
RD12_RS13790	COG3539	Fimbrial protein
RD12_RS13805	COG0613	PHP domain protein
RD12_RS13840	COG0084	hydrolase, TatD family'
RD12_RS13845	COG1136	(ABC) transporter
RD12_RS13860	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RD12_RS13865	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RD12_RS13870	COG1028	Short-chain dehydrogenase reductase Sdr
RD12_RS13875	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RD12_RS13890	COG1022	Amp-dependent synthetase and ligase
RD12_RS13925	COG2205	protein histidine kinase activity
RD12_RS13930	COG0745	RESPONSE REGULATOR receiver
RD12_RS13935	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
RD12_RS13945	COG1295	ribonuclease BN
RD12_RS13960	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RD12_RS13985	COG1534	Rna-binding protein
RD12_RS13990	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
RD12_RS13995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RD12_RS14005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RD12_RS14015	COG0248	Ppx GppA phosphatase
RD12_RS14040	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RD12_RS14055	COG2732	(Barnase) inhibitor
RD12_RS14065	COG0280	phosphate acetyltransferase
RD12_RS14065	COG0281	malic enzyme
RD12_RS14075	COG0436	Aminotransferase
RD12_RS14080	COG0741	lytic transglycosylase activity
RD12_RS14085	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
RD12_RS14110	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RD12_RS14110	COG1648	precorrin-2 dehydrogenase activity
RD12_RS14115	COG3468	outer membrane autotransporter barrel domain protein
RD12_RS14125	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RD12_RS14130	COG2027	D-alanyl-D-alanine carboxypeptidase
RD12_RS14135	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RD12_RS14140	COG0343	queuine tRNA-ribosyltransferase activity
RD12_RS14145	COG1862	Preprotein translocase
RD12_RS14150	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RD12_RS14155	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RD12_RS14170	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RD12_RS14175	COG1702	phosphate starvation-inducible protein PhoH
RD12_RS14180	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RD12_RS14185	COG4535	Mg2 and Co2 transporter CorC
RD12_RS14195	COG0667	Aldo Keto reductase
RD12_RS14220	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
RD12_RS14225	COG0745	RESPONSE REGULATOR receiver
RD12_RS14230	COG2201	protein-glutamate methylesterase activity
RD12_RS14240	COG0840	transmembrane signaling receptor activity
RD12_RS14255	COG0745	RESPONSE REGULATOR receiver
RD12_RS14290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RD12_RS14300	COG0739	heme binding
RD12_RS14310	COG0521	Mo-molybdopterin cofactor biosynthetic process
RD12_RS14320	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
RD12_RS14350	COG0625	glutathione transferase activity
RD12_RS14365	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RD12_RS14370	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RD12_RS14375	COG0126	phosphoglycerate kinase activity
RD12_RS14380	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RD12_RS14385	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RD12_RS14390	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RD12_RS14400	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RD12_RS14405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RD12_RS14415	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
RD12_RS14425	COG4566	intracellular signal transduction
RD12_RS14430	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RD12_RS14435	COG0339	signal peptide processing
RD12_RS14440	COG1999	signal sequence binding
RD12_RS14460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RD12_RS14470	COG1187	pseudouridine synthase activity
RD12_RS14475	COG3161	chorismate lyase activity
RD12_RS14480	COG2814	Major facilitator Superfamily
RD12_RS14490	COG0667	Aldo Keto reductase
RD12_RS14505	COG0335	large ribosomal subunit rRNA binding
RD12_RS14535	COG0175	sulfate reduction
RD12_RS14540	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RD12_RS14545	COG4208	sulfate ABC transporter
RD12_RS14550	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
RD12_RS14565	COG0450	alkyl hydroperoxide reductase
RD12_RS14570	COG1960	acyl-CoA dehydrogenase activity
RD12_RS14585	COG0123	including yeast histone deacetylase and acetoin utilization protein
RD12_RS14590	COG2951	lytic endotransglycosylase activity
RD12_RS14605	COG1555	photosystem II stabilization
RD12_RS14605	COG1596	polysaccharide export
RD12_RS14610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RD12_RS14615	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
RD12_RS14620	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
RD12_RS14640	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RD12_RS14645	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RD12_RS14650	COG0287	Prephenate dehydrogenase
RD12_RS14660	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RD12_RS14675	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RD12_RS14685	COG2814	Major facilitator Superfamily
RD12_RS14710	COG0583	DNA-binding transcription factor activity
RD12_RS14745	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RD12_RS14760	COG0667	Aldo Keto reductase
RD12_RS14770	COG5265	(ABC) transporter
RD12_RS14815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RD12_RS14820	COG0439	Biotin carboxylase
RD12_RS14825	COG2188	Transcriptional regulator
RD12_RS14850	COG0511	ligase activity, forming carbon-carbon bonds
RD12_RS14860	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
RD12_RS14880	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
RD12_RS14895	COG0500	methyltransferase
RD12_RS14900	COG5265	(ABC) transporter
RD12_RS14915	COG0028	Belongs to the TPP enzyme family
RD12_RS14920	COG0440	acetolactate synthase activity
RD12_RS14925	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RD12_RS14930	COG1183	phosphatidylcholine synthase activity
RD12_RS14940	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RD12_RS14945	COG1185	polyribonucleotide nucleotidyltransferase activity
RD12_RS14960	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RD12_RS14980	COG0149	triose-phosphate isomerase activity
RD12_RS14985	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RD12_RS14995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RD12_RS15005	COG3799	methylaspartate ammonia-lyase activity
RD12_RS15045	COG0583	DNA-binding transcription factor activity
RD12_RS15050	COG0626	cystathionine gamma-synthase activity
RD12_RS15055	COG3608	succinylglutamate desuccinylase aspartoacylase
RD12_RS15075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD12_RS15095	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
RD12_RS15110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RD12_RS15115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RD12_RS15120	COG1733	regulation of RNA biosynthetic process
RD12_RS15130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RD12_RS15135	COG0583	DNA-binding transcription factor activity
RD12_RS15140	COG1597	lipid kinase activity
RD12_RS15150	COG0671	phosphoesterase, PA-phosphatase related
RD12_RS15175	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RD12_RS15180	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RD12_RS15185	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RD12_RS15190	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RD12_RS15195	COG0649	NAD binding
RD12_RS15200	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
RD12_RS15210	COG1034	ATP synthesis coupled electron transport
RD12_RS15215	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
RD12_RS15220	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RD12_RS15230	COG0713	ATP synthesis coupled electron transport
RD12_RS15245	COG1007	ATP synthesis coupled electron transport
RD12_RS15255	COG4774	siderophore transport
RD12_RS15260	COG4774	siderophore transport
RD12_RS15275	COG0028	Belongs to the TPP enzyme family
RD12_RS15280	COG3181	Tripartite tricarboxylate transporter family receptor
RD12_RS15285	COG0583	DNA-binding transcription factor activity
RD12_RS15290	COG0560	Phosphoserine phosphatase
RD12_RS15295	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RD12_RS15300	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RD12_RS15305	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RD12_RS15315	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
RD12_RS15320	COG0308	aminopeptidase N
RD12_RS15340	COG0028	Belongs to the TPP enzyme family
RD12_RS15360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD12_RS15370	COG0318	PFAM AMP-dependent synthetase and ligase
RD12_RS15380	COG1802	Transcriptional regulator
RD12_RS15390	COG1802	Transcriptional regulator
RD12_RS15400	COG1028	Short-chain dehydrogenase reductase Sdr
RD12_RS15420	COG1126	abc transporter atp-binding protein
RD12_RS15425	COG0765	amino acid transport
RD12_RS15445	COG1538	Outer membrane efflux protein
RD12_RS15450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RD12_RS15455	COG2274	protein secretion by the type I secretion system
RD12_RS15460	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
RD12_RS15470	COG2994	toxin metabolic process
RD12_RS15485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD12_RS15490	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
RD12_RS15500	COG0583	DNA-binding transcription factor activity
RD12_RS15510	COG0142	geranyltranstransferase activity
RD12_RS15520	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RD12_RS15525	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RD12_RS15530	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RD12_RS15535	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RD12_RS15580	COG3712	iron ion homeostasis
RD12_RS15585	COG4774	siderophore transport
RD12_RS15590	COG2353	YceI-like domain
RD12_RS15610	COG0019	diaminopimelate decarboxylase activity
RD12_RS15630	COG0747	negative chemotaxis
RD12_RS15635	COG0601	transmembrane transport
RD12_RS15640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD12_RS15650	COG0154	amidase activity
RD12_RS15655	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RD12_RS15680	COG2154	pterin-4-alpha-carbinolamine dehydratase
RD12_RS15690	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RD12_RS15700	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RD12_RS15705	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RD12_RS15710	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RD12_RS15715	COG1929	Belongs to the glycerate kinase type-1 family
RD12_RS15720	COG0469	pyruvate kinase activity
RD12_RS15725	COG0700	Nucleoside recognition
RD12_RS15755	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
RD12_RS15760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RD12_RS15775	COG0823	Involved in the tonB-independent uptake of proteins
RD12_RS15785	COG0848	biopolymer transport protein
RD12_RS15790	COG0811	peptide transport
RD12_RS15795	COG0824	Thioesterase
RD12_RS15800	COG0442	prolyl-tRNA aminoacylation
RD12_RS15805	COG0494	nUDIX hydrolase
RD12_RS15820	COG2135	peptidase activity
RD12_RS15885	COG1196	nuclear chromosome segregation
RD12_RS16025	COG1464	Belongs to the NlpA lipoprotein family
RD12_RS16055	COG4211	Belongs to the binding-protein-dependent transport system permease family
RD12_RS16065	COG0154	amidase activity
RD12_RS16070	COG0288	reversible hydration of carbon dioxide
RD12_RS16085	COG0514	ATP-dependent DNA helicase (RecQ)
RD12_RS16090	COG2255	four-way junction helicase activity
RD12_RS16105	COG0632	four-way junction helicase activity
RD12_RS16110	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RD12_RS16130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RD12_RS16140	COG0006	proline dipeptidase activity
RD12_RS16165	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RD12_RS16180	COG4783	chaperone-mediated protein folding
RD12_RS16185	COG0429	hydrolase of the alpha beta-hydrolase fold
RD12_RS16215	COG0513	Belongs to the DEAD box helicase family
RD12_RS16235	COG1058	Belongs to the CinA family
RD12_RS16235	COG1546	Belongs to the CinA family
RD12_RS16240	COG1414	Transcriptional regulator
RD12_RS16260	COG0167	dihydroorotate dehydrogenase activity
RD12_RS16265	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
RD12_RS16270	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
RD12_RS16280	COG0583	DNA-binding transcription factor activity
RD12_RS16340	COG0281	malic enzyme
RD12_RS16340	COG0280	phosphate acetyltransferase
RD12_RS16350	COG0601	transmembrane transport
RD12_RS16355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD12_RS16360	COG4172	Belongs to the ABC transporter superfamily
RD12_RS16390	COG0640	Transcriptional regulator
RD12_RS16405	COG3135	benzoate transporter
RD12_RS16410	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RD12_RS16415	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RD12_RS16420	COG0742	ribosomal rna small subunit methyltransferase
RD12_RS16440	COG3639	organic phosphonate transmembrane transporter activity
RD12_RS16445	COG3639	organic phosphonate transmembrane transporter activity
RD12_RS16450	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RD12_RS16485	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RD12_RS16490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RD12_RS16500	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RD12_RS16505	COG1058	Belongs to the CinA family
RD12_RS16505	COG1546	Belongs to the CinA family
RD12_RS16510	COG0284	orotidine-5'-phosphate decarboxylase activity
RD12_RS16515	COG1252	NADH dehydrogenase
RD12_RS16530	COG3468	outer membrane autotransporter barrel domain protein
RD12_RS16535	COG0459	protein refolding
RD12_RS16540	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RD12_RS16560	COG1053	succinate dehydrogenase
RD12_RS16570	COG0583	DNA-binding transcription factor activity
RD12_RS16575	COG1053	succinate dehydrogenase
RD12_RS16595	COG3706	GGDEF domain
RD12_RS16630	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RD12_RS16635	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
RD12_RS16645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RD12_RS16655	COG0069	glutamate synthase activity
RD12_RS16660	COG2391	methyltransferase activity
RD12_RS16665	COG0679	Auxin Efflux Carrier
RD12_RS16690	COG0557	exoribonuclease II activity
RD12_RS16695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RD12_RS16705	COG3128	pkhd-type hydroxylase
RD12_RS16710	COG0776	regulation of translation
RD12_RS16740	COG0642	Histidine kinase
RD12_RS16745	COG3158	transport of potassium into the cell
RD12_RS16750	COG0137	argininosuccinate synthase activity
RD12_RS16755	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RD12_RS16760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RD12_RS16770	COG0583	DNA-binding transcription factor activity
RD12_RS16780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RD12_RS16800	COG2186	Transcriptional regulator
RD12_RS16810	COG2223	nitrite transmembrane transporter activity
RD12_RS16820	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RD12_RS16825	COG0450	alkyl hydroperoxide reductase
RD12_RS16845	COG1214	PFAM Peptidase M22, glycoprotease
RD12_RS16850	COG1573	uracil-dna glycosylase
RD12_RS16855	COG0477	Major facilitator Superfamily
RD12_RS16860	COG1196	nuclear chromosome segregation
RD12_RS16870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RD12_RS16875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RD12_RS16890	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RD12_RS16895	COG1122	ATPase activity
RD12_RS16900	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
RD12_RS16905	COG1268	BioY protein
RD12_RS16925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RD12_RS16960	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RD12_RS16965	COG2878	Part of a membrane complex involved in electron transport
RD12_RS16980	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RD12_RS16985	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
RD12_RS16990	COG0251	oxidation-reduction process
RD12_RS17000	COG3228	Belongs to the MtfA family
RD12_RS17005	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RD12_RS17015	COG0133	tryptophan synthase activity
RD12_RS17020	COG0159	tryptophan synthase activity
RD12_RS17025	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RD12_RS17030	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
RD12_RS17045	COG1530	ribonuclease E activity
RD12_RS17055	COG0546	phosphoglycolate phosphatase activity
RD12_RS17060	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RD12_RS17065	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
RD12_RS17075	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD12_RS17080	COG0583	DNA-binding transcription factor activity
RD12_RS17090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD12_RS17115	COG0251	oxidation-reduction process
RD12_RS17120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RD12_RS17120	COG1017	nitric oxide dioxygenase activity
RD12_RS17125	COG2031	fatty acid transporter
RD12_RS17130	COG1012	belongs to the aldehyde dehydrogenase family
RD12_RS17135	COG1802	Transcriptional regulator
RD12_RS17145	COG1278	Cold shock
RD12_RS17150	COG0583	DNA-binding transcription factor activity
RD12_RS17170	COG0183	Belongs to the thiolase family
RD12_RS17180	COG1960	acyl-CoA dehydrogenase activity
RD12_RS17185	COG0583	DNA-binding transcription factor activity
RD12_RS17190	COG3181	Tripartite tricarboxylate transporter family receptor
RD12_RS17195	COG1024	Enoyl-CoA hydratase
RD12_RS17200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD12_RS17205	COG1253	flavin adenine dinucleotide binding
RD12_RS17210	COG1285	pathogenesis
RD12_RS17220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RD12_RS17235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RD12_RS17245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RD12_RS17255	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD12_RS17260	COG3181	Tripartite tricarboxylate transporter family receptor
RD12_RS17265	COG1960	acyl-CoA dehydrogenase activity
RD12_RS17285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RD12_RS17290	COG1024	Enoyl-CoA hydratase
RD12_RS17295	COG1960	acyl-CoA dehydrogenase activity
RD12_RS17315	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RD12_RS17320	COG0022	dehydrogenase e1 component
RD12_RS17325	COG1024	Enoyl-CoA hydratase
RD12_RS17330	COG0508	dehydrogenase complex catalyzes the overall conversion of
RD12_RS17350	COG0683	leucine binding
RD12_RS17355	COG0559	Belongs to the binding-protein-dependent transport system permease family
RD12_RS17360	COG0411	ABC transporter
RD12_RS17370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RD12_RS17385	COG3181	Tripartite tricarboxylate transporter family receptor
RD12_RS17410	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RD12_RS17415	COG0793	Belongs to the peptidase S41A family
RD12_RS17420	COG4942	peptidase
RD12_RS17425	COG0588	phosphoglycerate mutase activity
RD12_RS17430	COG1054	Belongs to the UPF0176 family
RD12_RS17435	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RD12_RS17440	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
RD12_RS17445	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RD12_RS17450	COG3181	Tripartite tricarboxylate transporter family receptor
RD12_RS17465	COG2226	methyltransferase
RD12_RS17470	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
RD12_RS17485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD12_RS17490	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
RD12_RS17515	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD12_RS17540	COG1335	isochorismatase
RD12_RS17545	COG2309	aminopeptidase activity
RD12_RS17550	COG0596	Alpha beta hydrolase
RD12_RS17555	COG3473	Maleate cis-trans isomerase
RD12_RS17565	COG2068	MobA-Related Protein
RD12_RS17590	COG2204	response regulator
RD12_RS17595	COG5000	phosphorelay sensor kinase activity
RD12_RS17605	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RD12_RS17605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RD12_RS17615	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
RD12_RS17640	COG0583	DNA-binding transcription factor activity
RD12_RS17655	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RD12_RS17660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RD12_RS17665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD12_RS17680	COG0758	DNA mediated transformation
RD12_RS17685	COG1522	sequence-specific DNA binding
RD12_RS17695	COG0242	peptide deformylase activity
RD12_RS17705	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RD12_RS17715	COG0546	phosphoglycolate phosphatase activity
RD12_RS17735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RD12_RS17740	COG1942	4-Oxalocrotonate Tautomerase
RD12_RS17745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD12_RS17765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RD12_RS17785	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RD12_RS17790	COG1024	Enoyl-CoA hydratase
RD12_RS17795	COG1414	Transcriptional regulator
RD12_RS17800	COG0318	PFAM AMP-dependent synthetase and ligase
RD12_RS17805	COG3181	Tripartite tricarboxylate transporter family receptor
RD12_RS17835	COG0583	DNA-binding transcription factor activity
RD12_RS17850	COG3422	double-strand break repair
RD12_RS17855	COG0330	HflC and HflK could
RD12_RS17865	COG0251	oxidation-reduction process
RD12_RS17910	COG3723	Recombinational DNA repair protein, rece pathway
RD12_RS17945	COG0582	viral genome integration into host DNA
RD12_RS17970	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RD12_RS17980	COG0706	membrane insertase activity
RD12_RS17985	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RD12_RS17990	COG0594	ribonuclease P activity
RD12_RS17995	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RD12_RS18000	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RD12_RS18015	COG1414	Transcriptional regulator
RD12_RS18020	COG0154	amidase activity
RD12_RS18035	COG1304	FMN binding
RD12_RS18055	COG1960	acyl-CoA dehydrogenase activity
RD12_RS18075	COG1960	acyl-CoA dehydrogenase activity
RD12_RS18085	COG0183	Belongs to the thiolase family
RD12_RS18090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RD12_RS18105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RD12_RS18110	COG3181	Tripartite tricarboxylate transporter family receptor
RD12_RS18120	COG2358	TRAP transporter, solute receptor (TAXI family
RD12_RS18130	COG1629	transport
RD12_RS18135	COG2922	Belongs to the Smg family
RD12_RS18160	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
RD12_RS18165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD12_RS18170	COG1028	Short-chain dehydrogenase reductase Sdr
RD12_RS18175	COG1012	belongs to the aldehyde dehydrogenase family
RD12_RS18185	COG0028	Belongs to the TPP enzyme family
RD12_RS18190	COG1522	sequence-specific DNA binding
RD12_RS18195	COG3781	membrane
RD12_RS18205	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RD12_RS18225	COG4206	TonB-dependent receptor
RD12_RS18230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RD12_RS18235	COG2022	thiamine diphosphate biosynthetic process
RD12_RS18240	COG0351	phosphomethylpyrimidine kinase
RD12_RS18245	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RD12_RS18260	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RD12_RS18270	COG0628	permease
RD12_RS18280	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RD12_RS18290	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RD12_RS18295	COG0049	tRNA binding
RD12_RS18300	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RD12_RS18305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RD12_RS18310	COG0051	transcription antitermination factor activity, RNA binding
RD12_RS18315	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RD12_RS18320	COG0088	Forms part of the polypeptide exit tunnel
RD12_RS18325	COG0089	rRNA binding
RD12_RS18330	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RD12_RS18335	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RD12_RS18340	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RD12_RS18345	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RD12_RS18350	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RD12_RS18355	COG0255	Belongs to the universal ribosomal protein uL29 family
RD12_RS18360	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RD12_RS18380	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RD12_RS18385	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RD12_RS18390	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RD12_RS18395	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RD12_RS18400	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RD12_RS18405	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RD12_RS18410	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RD12_RS18415	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RD12_RS18420	COG1841	ribosomal large subunit assembly
RD12_RS18425	COG0200	Binds to the 23S rRNA
RD12_RS18430	COG0201	protein transport
RD12_RS18435	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RD12_RS18440	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RD12_RS18445	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RD12_RS18450	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RD12_RS18455	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RD12_RS18460	COG0202	RNA polymerase activity
RD12_RS18465	COG0203	ribosomal protein L17
RD12_RS18475	COG1324	tolerance protein
RD12_RS18480	COG4232	protein-disulfide reductase activity
RD12_RS18495	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RD12_RS18505	COG1333	cytochrome c biogenesis protein
RD12_RS18510	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RD12_RS18520	COG1965	Belongs to the frataxin family
RD12_RS18530	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RD12_RS18535	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RD12_RS18540	COG0232	Belongs to the dGTPase family. Type 2 subfamily
RD12_RS18555	COG2814	Major facilitator Superfamily
RD12_RS18560	COG0629	single-stranded DNA binding
RD12_RS18600	COG0402	S-adenosylhomocysteine deaminase activity
RD12_RS18610	COG0438	transferase activity, transferring glycosyl groups
RD12_RS18630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD12_RS18655	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RD12_RS18660	COG2186	Transcriptional regulator
RD12_RS18680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RD12_RS18685	COG1956	GAF domain-containing protein
RD12_RS18690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RD12_RS18700	COG1652	LysM domain
RD12_RS18715	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RD12_RS18730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RD12_RS18755	COG3181	Tripartite tricarboxylate transporter family receptor
RD12_RS18770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD12_RS18785	COG1024	Enoyl-CoA hydratase
RD12_RS18800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD12_RS18805	COG1309	transcriptional regulator
RD12_RS18810	COG2816	NAD+ diphosphatase activity
RD12_RS18815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RD12_RS18900	COG2814	Major facilitator Superfamily
RD12_RS18905	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RD12_RS18925	COG1999	signal sequence binding
RD12_RS18930	COG0109	protoheme IX farnesyltransferase activity
RD12_RS18970	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RD12_RS18990	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RD12_RS18995	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RD12_RS19005	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
RD12_RS19010	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
RD12_RS19020	COG0067	glutamate synthase
RD12_RS19020	COG0069	glutamate synthase activity
RD12_RS19020	COG0070	glutamate synthase
RD12_RS19030	COG3047	cAMP biosynthetic process
RD12_RS19040	COG1127	ABC transporter
RD12_RS19045	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RD12_RS19050	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RD12_RS19055	COG2853	Lipoprotein
RD12_RS19065	COG1131	(ABC) transporter
RD12_RS19070	COG0842	Transport permease protein
RD12_RS19080	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RD12_RS19085	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RD12_RS19090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RD12_RS19095	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RD12_RS19100	COG0131	Imidazoleglycerol-phosphate dehydratase
RD12_RS19105	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RD12_RS19110	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RD12_RS19115	COG0107	imidazoleglycerol-phosphate synthase activity
RD12_RS19120	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RD12_RS19125	COG0140	phosphoribosyl-ATP diphosphatase activity
RD12_RS19130	COG0537	adenosine 5'-monophosphoramidase activity
RD12_RS19135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RD12_RS19140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RD12_RS19155	COG3181	Tripartite tricarboxylate transporter family receptor
RD12_RS19190	COG3702	type iv secretory pathway
RD12_RS19195	COG3451	type IV secretory pathway VirB4
RD12_RS19210	COG3736	Type IV secretory pathway, component VirB8
RD12_RS19215	COG3504	Conjugal transfer protein
RD12_RS19220	COG2948	multi-organism process
RD12_RS19225	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
RD12_RS19235	COG0697	spore germination
RD12_RS19255	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RD12_RS19260	COG0747	negative chemotaxis
RD12_RS19265	COG0601	transmembrane transport
RD12_RS19270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD12_RS19275	COG0444	Belongs to the ABC transporter superfamily
RD12_RS19285	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
RD12_RS19295	COG0494	nUDIX hydrolase
RD12_RS19335	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
RD12_RS19340	COG0237	dephospho-CoA kinase activity
RD12_RS19345	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
RD12_RS19360	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RD12_RS19365	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
RD12_RS19375	COG0477	Major facilitator Superfamily
RD12_RS19380	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RD12_RS19395	COG1126	abc transporter atp-binding protein
RD12_RS19400	COG0765	amino acid transport
RD12_RS19405	COG4597	amino acid ABC transporter
RD12_RS19410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD12_RS19415	COG2884	Cell division ATP-binding protein ftsE
RD12_RS19420	COG2177	Part of the ABC transporter FtsEX involved in
RD12_RS19425	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
RD12_RS19435	COG1194	a g-specific adenine glycosylase
RD12_RS19445	COG2226	methyltransferase
RD12_RS19455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD12_RS19460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD12_RS19475	COG1024	Enoyl-CoA hydratase
RD12_RS19495	COG1024	Enoyl-CoA hydratase
RD12_RS19500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD12_RS19505	COG3181	Tripartite tricarboxylate transporter family receptor
RD12_RS19515	COG0753	catalase activity
RD12_RS19520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD12_RS19525	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
RD12_RS19535	COG2175	clavaminate synthase activity
RD12_RS19540	COG1473	amidohydrolase
RD12_RS19545	COG4608	Belongs to the ABC transporter superfamily
RD12_RS19550	COG0444	Belongs to the ABC transporter superfamily
RD12_RS19565	COG0747	negative chemotaxis
RD12_RS19570	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RD12_RS19605	COG0436	Aminotransferase
RD12_RS19610	COG1278	Cold shock