locus-tag	class	description
WU22_RS00005	COG0445	tRNA wobble uridine modification
WU22_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
WU22_RS00015	COG1192	Involved in chromosome partitioning
WU22_RS00025	COG1475	DNA binding
WU22_RS00030	COG0252	asparaginase activity
WU22_RS00055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WU22_RS00065	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WU22_RS00075	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WU22_RS00080	COG0081	regulation of translation
WU22_RS00085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WU22_RS00090	COG0222	ribosome binding
WU22_RS00095	COG0085	RNA polymerase activity
WU22_RS00100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WU22_RS00140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU22_RS00165	COG1024	Enoyl-CoA hydratase
WU22_RS00185	COG0752	glycyl-tRNA synthetase alpha subunit
WU22_RS00190	COG0751	glycine-tRNA ligase activity
WU22_RS00195	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
WU22_RS00200	COG0204	Acyl-transferase
WU22_RS00215	COG0242	peptide deformylase activity
WU22_RS00250	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
WU22_RS00255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WU22_RS00260	COG2813	Specifically methylates the guanine in position
WU22_RS00260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WU22_RS00275	COG2223	nitrite transmembrane transporter activity
WU22_RS00285	COG1794	racemase activity, acting on amino acids and derivatives
WU22_RS00290	COG1126	abc transporter atp-binding protein
WU22_RS00295	COG0765	amino acid transport
WU22_RS00300	COG0765	amino acid transport
WU22_RS00305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WU22_RS00370	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
WU22_RS00400	COG0326	Molecular chaperone. Has ATPase activity
WU22_RS00405	COG0625	glutathione transferase activity
WU22_RS00420	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WU22_RS00425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WU22_RS00455	COG0438	transferase activity, transferring glycosyl groups
WU22_RS00460	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WU22_RS00465	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WU22_RS00495	COG0859	PFAM glycosyl transferase family 9
WU22_RS00510	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
WU22_RS00520	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WU22_RS00525	COG1127	ABC transporter
WU22_RS00545	COG1686	Belongs to the peptidase S11 family
WU22_RS00555	COG2921	Belongs to the UPF0250 family
WU22_RS00560	COG0321	lipoyl(octanoyl) transferase activity
WU22_RS00565	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WU22_RS00600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WU22_RS00610	COG0018	arginyl-trna synthetase
WU22_RS00630	COG0395	ABC-type sugar transport system, permease component
WU22_RS00635	COG1175	transmembrane transport
WU22_RS00640	COG1653	transport
WU22_RS00645	COG3842	ATPase activity
WU22_RS00650	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
WU22_RS00660	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
WU22_RS00680	COG1609	Transcriptional regulator
WU22_RS00690	COG0154	amidase activity
WU22_RS00695	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WU22_RS00705	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
WU22_RS00715	COG0583	DNA-binding transcription factor activity
WU22_RS00730	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
WU22_RS00735	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WU22_RS00750	COG1802	Transcriptional regulator
WU22_RS00765	COG1024	Enoyl-CoA hydratase
WU22_RS00775	COG3181	Tripartite tricarboxylate transporter family receptor
WU22_RS00790	COG1984	allophanate hydrolase subunit 2
WU22_RS00795	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
WU22_RS00805	COG0583	DNA-binding transcription factor activity
WU22_RS00810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WU22_RS00820	COG5002	protein histidine kinase activity
WU22_RS00830	COG5002	protein histidine kinase activity
WU22_RS00835	COG0745	RESPONSE REGULATOR receiver
WU22_RS00840	COG2226	methyltransferase
WU22_RS00855	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WU22_RS00875	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
WU22_RS00885	COG0513	Belongs to the DEAD box helicase family
WU22_RS00890	COG1280	lysine exporter protein (LysE YggA)
WU22_RS00895	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
WU22_RS00930	COG1054	Belongs to the UPF0176 family
WU22_RS00935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WU22_RS00935	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WU22_RS00945	COG0489	protein tyrosine kinase activity
WU22_RS00960	COG0717	Belongs to the dCTP deaminase family
WU22_RS00990	COG2081	HI0933 family
WU22_RS01000	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WU22_RS01010	COG0404	The glycine cleavage system catalyzes the degradation of glycine
WU22_RS01015	COG0509	glycine decarboxylation via glycine cleavage system
WU22_RS01020	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WU22_RS01020	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WU22_RS01060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WU22_RS01075	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
WU22_RS01085	COG1414	Transcriptional regulator
WU22_RS01090	COG1028	Short-chain dehydrogenase reductase Sdr
WU22_RS01095	COG2031	fatty acid transporter
WU22_RS01100	COG1250	3-hydroxyacyl-CoA dehydrogenase
WU22_RS01110	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
WU22_RS01115	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
WU22_RS01125	COG4257	antibiotic catabolic process
WU22_RS01150	COG1012	belongs to the aldehyde dehydrogenase family
WU22_RS01155	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
WU22_RS01160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WU22_RS01185	COG1028	Short-chain dehydrogenase reductase Sdr
WU22_RS01195	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WU22_RS01210	COG2188	Transcriptional regulator
WU22_RS01215	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
WU22_RS01240	COG0617	tRNA 3'-terminal CCA addition
WU22_RS01255	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WU22_RS01260	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WU22_RS01265	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WU22_RS01270	COG0586	Pfam SNARE associated Golgi protein
WU22_RS01275	COG0860	N-Acetylmuramoyl-L-alanine amidase
WU22_RS01280	COG0802	atpase or kinase
WU22_RS01285	COG0114	fumarate hydratase activity
WU22_RS01295	COG3181	Tripartite tricarboxylate transporter family receptor
WU22_RS01305	COG0405	Gamma-glutamyltransferase
WU22_RS01310	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU22_RS01320	COG1960	acyl-CoA dehydrogenase activity
WU22_RS01345	COG1294	oxidase, subunit
WU22_RS01355	COG4988	ABC transporter
WU22_RS01360	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
WU22_RS01365	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WU22_RS01380	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
WU22_RS01410	COG2969	positive regulation of protein catabolic process
WU22_RS01415	COG0625	glutathione transferase activity
WU22_RS01420	COG2857	Cytochrome c1
WU22_RS01425	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WU22_RS01430	COG0723	plastoquinol--plastocyanin reductase activity
WU22_RS01435	COG1970	mechanosensitive ion channel activity
WU22_RS01440	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
WU22_RS01455	COG2808	Putative FMN-binding domain
WU22_RS01460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WU22_RS01465	COG0747	negative chemotaxis
WU22_RS01470	COG0657	acetylesterase activity
WU22_RS01480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WU22_RS01485	COG2207	Transcriptional regulator
WU22_RS01490	COG0129	dihydroxy-acid dehydratase activity
WU22_RS01495	COG2814	Major facilitator Superfamily
WU22_RS01500	COG0583	DNA-binding transcription factor activity
WU22_RS01510	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
WU22_RS01580	COG1024	Enoyl-CoA hydratase
WU22_RS01585	COG1960	acyl-CoA dehydrogenase activity
WU22_RS01610	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
WU22_RS01615	COG0352	thiamine-phosphate diphosphorylase activity
WU22_RS01630	COG1678	Uncharacterized ACR, COG1678
WU22_RS01635	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WU22_RS01640	COG0540	Belongs to the ATCase OTCase family
WU22_RS01655	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WU22_RS01665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WU22_RS01700	COG1234	tRNA 3'-trailer cleavage
WU22_RS01720	COG3064	Membrane
WU22_RS01750	COG1683	Conserved Protein
WU22_RS01755	COG1120	ATPase activity
WU22_RS01760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WU22_RS01765	COG4558	Periplasmic binding protein
WU22_RS01770	COG3720	iron ion transport
WU22_RS01780	COG3712	iron ion homeostasis
WU22_RS01785	COG1595	DNA-templated transcription, initiation
WU22_RS01820	COG1802	Transcriptional regulator
WU22_RS01830	COG3069	C4-dicarboxylate transmembrane transporter activity
WU22_RS01840	COG1012	belongs to the aldehyde dehydrogenase family
WU22_RS01875	COG2860	membrane
WU22_RS01880	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
WU22_RS01885	COG0708	Exodeoxyribonuclease III
WU22_RS01890	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WU22_RS01895	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WU22_RS01900	COG0154	amidase activity
WU22_RS01905	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WU22_RS01910	COG1077	Cell shape determining protein MreB Mrl
WU22_RS01915	COG1792	Involved in formation and maintenance of cell shape
WU22_RS01925	COG0768	penicillin binding
WU22_RS01930	COG0772	Belongs to the SEDS family
WU22_RS01935	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
WU22_RS01940	COG0471	metal ion transport
WU22_RS01945	COG1309	transcriptional regulator
WU22_RS01955	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WU22_RS01970	COG2823	Periplasmic or secreted lipoprotein
WU22_RS01975	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
WU22_RS01990	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
WU22_RS02010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU22_RS02020	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU22_RS02040	COG0492	ferredoxin-NADP+ reductase activity
WU22_RS02050	COG3181	Tripartite tricarboxylate transporter family receptor
WU22_RS02055	COG1024	Enoyl-CoA hydratase
WU22_RS02055	COG1250	3-hydroxyacyl-CoA dehydrogenase
WU22_RS02060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU22_RS02065	COG0028	Belongs to the TPP enzyme family
WU22_RS02090	COG3181	Tripartite tricarboxylate transporter family receptor
WU22_RS02100	COG0697	spore germination
WU22_RS02130	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
WU22_RS02135	COG0463	Glycosyl transferase, family 2
WU22_RS02155	COG0786	glutamate:sodium symporter activity
WU22_RS02165	COG2031	fatty acid transporter
WU22_RS02180	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WU22_RS02185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WU22_RS02210	COG3181	Tripartite tricarboxylate transporter family receptor
WU22_RS02220	COG0277	FAD linked oxidase domain protein
WU22_RS02225	COG1960	acyl-CoA dehydrogenase activity
WU22_RS02230	COG1960	acyl-CoA dehydrogenase activity
WU22_RS02240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WU22_RS02255	COG2072	flavoprotein involved in K transport
WU22_RS02260	COG0604	alcohol dehydrogenase
WU22_RS02275	COG1024	Enoyl-CoA hydratase
WU22_RS02295	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WU22_RS02300	COG1522	sequence-specific DNA binding
WU22_RS02305	COG0183	Belongs to the thiolase family
WU22_RS02315	COG1960	acyl-CoA dehydrogenase activity
WU22_RS02355	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
WU22_RS02360	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WU22_RS02365	COG2890	protein-(glutamine-N5) methyltransferase activity
WU22_RS02370	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
WU22_RS02380	COG3181	Tripartite tricarboxylate transporter family receptor
WU22_RS02415	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
WU22_RS02420	COG1660	Displays ATPase and GTPase activities
WU22_RS02430	COG2010	Cytochrome c
WU22_RS02430	COG1529	Aldehyde oxidase and xanthine dehydrogenase
WU22_RS02435	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
WU22_RS02445	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
WU22_RS02450	COG1137	ATPase activity
WU22_RS02465	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
WU22_RS02475	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
WU22_RS02510	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WU22_RS02515	COG3568	Endonuclease Exonuclease Phosphatase
WU22_RS02520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WU22_RS02550	COG0154	amidase activity
WU22_RS02560	COG1414	Transcriptional regulator
WU22_RS02570	COG1250	3-hydroxyacyl-CoA dehydrogenase
WU22_RS02570	COG1024	Enoyl-CoA hydratase
WU22_RS02580	COG2132	Multicopper oxidase
WU22_RS02610	COG1250	3-hydroxyacyl-CoA dehydrogenase
WU22_RS02635	COG1024	Enoyl-CoA hydratase
WU22_RS02640	COG1024	Enoyl-CoA hydratase
WU22_RS02645	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
WU22_RS02665	COG0601	transmembrane transport
WU22_RS02670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WU22_RS02675	COG4172	Belongs to the ABC transporter superfamily
WU22_RS02685	COG2195	Cleaves the N-terminal amino acid of tripeptides
WU22_RS02695	COG0210	DNA helicase
WU22_RS02700	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
WU22_RS02705	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WU22_RS02715	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WU22_RS02720	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WU22_RS02725	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WU22_RS02730	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WU22_RS02735	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WU22_RS02740	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WU22_RS02750	COG0356	it plays a direct role in the translocation of protons across the membrane
WU22_RS02775	COG1024	Enoyl-CoA hydratase
WU22_RS02780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WU22_RS02785	COG3634	alkyl hydroperoxide reductase activity
WU22_RS02795	COG0037	tRNA processing
WU22_RS02805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WU22_RS02810	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WU22_RS02815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WU22_RS02820	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
WU22_RS02825	COG2967	ApaG domain
WU22_RS02830	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WU22_RS02835	COG0546	phosphoglycolate phosphatase activity
WU22_RS02845	COG0512	Glutamine amidotransferase of anthranilate synthase
WU22_RS02850	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WU22_RS02855	COG0134	indole-3-glycerol-phosphate synthase activity
WU22_RS02875	COG1960	acyl-CoA dehydrogenase activity
WU22_RS02880	COG0583	DNA-binding transcription factor activity
WU22_RS02895	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
WU22_RS02900	COG0259	pyridoxamine-phosphate oxidase activity
WU22_RS02910	COG2814	Major facilitator Superfamily
WU22_RS02915	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
WU22_RS02920	COG2188	Transcriptional regulator
WU22_RS02925	COG0318	PFAM AMP-dependent synthetase and ligase
WU22_RS02945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WU22_RS02955	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WU22_RS02970	COG1215	transferase activity, transferring glycosyl groups
WU22_RS02980	COG0601	transmembrane transport
WU22_RS02995	COG0488	(ABC) transporter
WU22_RS03015	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
WU22_RS03020	COG2894	cell division
WU22_RS03025	COG0850	regulation of cytokinetic process
WU22_RS03030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WU22_RS03035	COG1271	oxidase subunit
WU22_RS03070	COG2979	Protein of unknown function (DUF533)
WU22_RS03090	COG0741	lytic transglycosylase activity
WU22_RS03090	COG1388	LysM domain
WU22_RS03095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WU22_RS03100	COG2226	methyltransferase
WU22_RS03105	COG0328	RNA-DNA hybrid ribonuclease activity
WU22_RS03155	COG2030	dehydratase
WU22_RS03160	COG0183	Belongs to the thiolase family
WU22_RS03205	COG1960	acyl-CoA dehydrogenase activity
WU22_RS03220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU22_RS03225	COG1028	Short-chain dehydrogenase reductase Sdr
WU22_RS03240	COG2718	Belongs to the UPF0229 family
WU22_RS03245	COG2719	SpoVR family
WU22_RS03270	COG2188	Transcriptional regulator
WU22_RS03285	COG0633	Ferredoxin
WU22_RS03295	COG0829	nickel cation binding
WU22_RS03300	COG0831	urea catabolic process
WU22_RS03310	COG0832	Belongs to the urease beta subunit family
WU22_RS03315	COG0804	urea catabolic process
WU22_RS03325	COG0830	nickel cation binding
WU22_RS03330	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
WU22_RS03350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WU22_RS03355	COG0601	transmembrane transport
WU22_RS03360	COG0747	negative chemotaxis
WU22_RS03370	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WU22_RS03375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WU22_RS03385	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
WU22_RS03395	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
WU22_RS03400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WU22_RS03405	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
WU22_RS03420	COG0438	transferase activity, transferring glycosyl groups
WU22_RS03435	COG0438	transferase activity, transferring glycosyl groups
WU22_RS03440	COG0438	transferase activity, transferring glycosyl groups
WU22_RS03445	COG0166	Belongs to the GPI family
WU22_RS03460	COG0277	FAD linked oxidase domain protein
WU22_RS03465	COG0745	RESPONSE REGULATOR receiver
WU22_RS03470	COG0642	Histidine kinase
WU22_RS03475	COG1368	sulfuric ester hydrolase activity
WU22_RS03485	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
WU22_RS03510	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WU22_RS03520	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
WU22_RS03525	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
WU22_RS03535	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WU22_RS03540	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WU22_RS03545	COG0193	aminoacyl-tRNA hydrolase activity
WU22_RS03555	COG0012	GTP binding
WU22_RS03560	COG0582	viral genome integration into host DNA
WU22_RS03585	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WU22_RS03650	COG0745	RESPONSE REGULATOR receiver
WU22_RS03665	COG1309	transcriptional regulator
WU22_RS03695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WU22_RS03705	COG0405	Gamma-glutamyltransferase
WU22_RS03720	COG1280	lysine exporter protein (LysE YggA)
WU22_RS03780	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
WU22_RS03785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WU22_RS03795	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
WU22_RS03800	COG0513	Belongs to the DEAD box helicase family
WU22_RS03810	COG0617	tRNA 3'-terminal CCA addition
WU22_RS03825	COG0477	Major facilitator Superfamily
WU22_RS03835	COG0583	DNA-binding transcription factor activity
WU22_RS03850	COG1950	PFAM Membrane protein of
WU22_RS03855	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
WU22_RS03870	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
WU22_RS03880	COG1560	Kdo2-lipid A biosynthetic process
WU22_RS03885	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
WU22_RS03895	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
WU22_RS03905	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
WU22_RS03915	COG0803	Belongs to the bacterial solute-binding protein 9 family
WU22_RS03935	COG0735	belongs to the Fur family
WU22_RS03940	COG0523	cobalamin synthesis protein
WU22_RS03950	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
WU22_RS03955	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
WU22_RS03965	COG2096	Adenosyltransferase
WU22_RS03980	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
WU22_RS03985	COG2084	Dehydrogenase
WU22_RS04035	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WU22_RS04040	COG0129	dihydroxy-acid dehydratase activity
WU22_RS04045	COG4654	Cytochrome c, class I
WU22_RS04050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WU22_RS04100	COG1473	amidohydrolase
WU22_RS04105	COG0418	dihydroorotase activity
WU22_RS04110	COG0488	(ABC) transporter
WU22_RS04120	COG2001	Belongs to the MraZ family
WU22_RS04125	COG0275	rRNA processing
WU22_RS04130	COG3116	cell division
WU22_RS04140	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WU22_RS04145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WU22_RS04150	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WU22_RS04160	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WU22_RS04165	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WU22_RS04170	COG1181	Belongs to the D-alanine--D-alanine ligase family
WU22_RS04175	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
WU22_RS04185	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
WU22_RS04190	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
WU22_RS04200	COG0739	heme binding
WU22_RS04205	COG0653	protein targeting
WU22_RS04225	COG1028	Short-chain dehydrogenase reductase Sdr
WU22_RS04230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WU22_RS04235	COG1522	sequence-specific DNA binding
WU22_RS04255	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
WU22_RS04265	COG0557	exoribonuclease II activity
WU22_RS04270	COG3150	esterase
WU22_RS04275	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WU22_RS04280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WU22_RS04285	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
WU22_RS04290	COG0511	ligase activity, forming carbon-carbon bonds
WU22_RS04295	COG0439	Biotin carboxylase
WU22_RS04300	COG2264	protein methyltransferase activity
WU22_RS04310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WU22_RS04335	COG1696	Membrane protein involved in D-alanine export
WU22_RS04340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WU22_RS04375	COG1522	sequence-specific DNA binding
WU22_RS04390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WU22_RS04395	COG1042	CoA-binding domain protein
WU22_RS04395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WU22_RS04395	COG0045	succinate-CoA ligase (ADP-forming) activity
WU22_RS04410	COG1802	Transcriptional regulator
WU22_RS04415	COG3069	C4-dicarboxylate transmembrane transporter activity
WU22_RS04420	COG0513	Belongs to the DEAD box helicase family
WU22_RS04425	COG0346	lactoylglutathione lyase activity
WU22_RS04430	COG1335	isochorismatase
WU22_RS04435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WU22_RS04440	COG1116	anion transmembrane transporter activity
WU22_RS04455	COG3028	Belongs to the UPF0307 family
WU22_RS04460	COG0312	modulator of DNA gyrase
WU22_RS04465	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
WU22_RS04470	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WU22_RS04475	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
WU22_RS04480	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
WU22_RS04490	COG0316	Belongs to the HesB IscA family
WU22_RS04495	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
WU22_RS04510	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WU22_RS04520	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WU22_RS04525	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WU22_RS04540	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WU22_RS04540	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WU22_RS04570	COG0583	DNA-binding transcription factor activity
WU22_RS04575	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU22_RS04610	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
WU22_RS04620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WU22_RS04625	COG1845	cytochrome c oxidase, subunit III
WU22_RS04630	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
WU22_RS04635	COG0640	Transcriptional regulator
WU22_RS04655	COG3220	belongs to the UPF0276 family
WU22_RS04700	COG1666	GTP binding
WU22_RS04735	COG0312	modulator of DNA gyrase
WU22_RS04740	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WU22_RS04745	COG3210	domain, Protein
WU22_RS04745	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
WU22_RS04745	COG3210	domain, Protein
WU22_RS04745	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
WU22_RS04745	COG3064	Membrane
WU22_RS04745	COG3064	Membrane
WU22_RS04750	COG0277	FAD linked oxidase domain protein
WU22_RS04755	COG0277	FAD linked oxidase domain protein
WU22_RS04760	COG0277	FAD linked oxidase domain protein
WU22_RS04765	COG0247	lactate metabolic process
WU22_RS04770	COG2819	hydrolase of the alpha beta superfamily
WU22_RS04795	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
WU22_RS04815	COG0583	DNA-binding transcription factor activity
WU22_RS04820	COG0482	sulfurtransferase activity
WU22_RS04825	COG0730	response to heat
WU22_RS04830	COG0625	glutathione transferase activity
WU22_RS04835	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WU22_RS04840	COG3909	cytochrome
WU22_RS04880	COG0154	amidase activity
WU22_RS04885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU22_RS04890	COG1024	Enoyl-CoA hydratase
WU22_RS04905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WU22_RS04920	COG1028	Short-chain dehydrogenase reductase Sdr
WU22_RS04925	COG1414	Transcriptional regulator
WU22_RS04935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WU22_RS04940	COG0251	oxidation-reduction process
WU22_RS04945	COG0559	Belongs to the binding-protein-dependent transport system permease family
WU22_RS04965	COG1902	pentaerythritol trinitrate reductase activity
WU22_RS04980	COG0583	DNA-binding transcription factor activity
WU22_RS04990	COG0590	tRNA wobble adenosine to inosine editing
WU22_RS04995	COG2807	transmembrane transport
WU22_RS05015	COG0154	amidase activity
WU22_RS05020	COG0307	riboflavin synthase, alpha
WU22_RS05025	COG3181	Tripartite tricarboxylate transporter family receptor
WU22_RS05030	COG1522	sequence-specific DNA binding
WU22_RS05040	COG0318	PFAM AMP-dependent synthetase and ligase
WU22_RS05050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WU22_RS05070	COG1063	alcohol dehydrogenase
WU22_RS05095	COG1418	mRNA catabolic process
WU22_RS05100	COG1448	Aminotransferase
WU22_RS05105	COG0583	DNA-binding transcription factor activity
WU22_RS05115	COG0477	Major facilitator Superfamily
WU22_RS05120	COG1028	Short-chain dehydrogenase reductase Sdr
WU22_RS05135	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
WU22_RS05140	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
WU22_RS05145	COG0583	DNA-binding transcription factor activity
WU22_RS05205	COG1028	Short-chain dehydrogenase reductase Sdr
WU22_RS05210	COG1309	transcriptional regulator
WU22_RS05220	COG2982	Protein involved in outer membrane biogenesis
WU22_RS05225	COG2818	Glycosylase
WU22_RS05245	COG1653	transport
WU22_RS05255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WU22_RS05260	COG3842	ATPase activity
WU22_RS05265	COG0395	ABC-type sugar transport system, permease component
WU22_RS05270	COG1175	transmembrane transport
WU22_RS05290	COG3181	Tripartite tricarboxylate transporter family receptor
WU22_RS05295	COG2186	Transcriptional regulator
WU22_RS05325	COG1454	alcohol dehydrogenase
WU22_RS05345	COG2011	ABC-type metal ion transport system permease component
WU22_RS05350	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WU22_RS05355	COG1501	Belongs to the glycosyl hydrolase 31 family
WU22_RS05380	COG0318	PFAM AMP-dependent synthetase and ligase
WU22_RS05385	COG1473	amidohydrolase
WU22_RS05395	COG2855	membrane
WU22_RS05405	COG2239	Acts as a magnesium transporter
WU22_RS05425	COG3181	Tripartite tricarboxylate transporter family receptor
WU22_RS05435	COG1722	exodeoxyribonuclease VII activity
WU22_RS05440	COG0142	geranyltranstransferase activity
WU22_RS05445	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
WU22_RS05450	COG1469	GTP cyclohydrolase I activity
WU22_RS05455	COG0360	Binds together with S18 to 16S ribosomal RNA
WU22_RS05460	COG2965	DNA replication, synthesis of RNA primer
WU22_RS05465	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WU22_RS05470	COG0359	binds to the 23S rRNA
WU22_RS05480	COG0305	Participates in initiation and elongation during chromosome replication
WU22_RS05490	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
WU22_RS05495	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
WU22_RS05500	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WU22_RS05505	COG3737	Protein of unknown function (DUF498/DUF598)
WU22_RS05510	COG0436	Aminotransferase
WU22_RS05535	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
WU22_RS05565	COG0268	Binds directly to 16S ribosomal RNA
WU22_RS05575	COG0728	peptidoglycan biosynthetic process
WU22_RS05585	COG0563	adenylate kinase activity
WU22_RS05590	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
WU22_RS05595	COG2835	tetraacyldisaccharide 4'-kinase activity
WU22_RS05600	COG1663	tetraacyldisaccharide 4'-kinase activity
WU22_RS05605	COG0848	biopolymer transport protein
WU22_RS05610	COG0811	peptide transport
WU22_RS05620	COG1570	exodeoxyribonuclease VII activity
WU22_RS05625	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WU22_RS05630	COG0038	chloride channel
WU22_RS05635	COG0183	Belongs to the thiolase family
WU22_RS05645	COG1278	Cold shock
WU22_RS05650	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
WU22_RS05660	COG4953	penicillin-binding protein 1C
WU22_RS05665	COG0542	response to heat
WU22_RS05670	COG2995	paraquat-inducible protein a
WU22_RS05675	COG3008	intermembrane lipid transfer
WU22_RS05675	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WU22_RS05685	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
WU22_RS05685	COG0506	proline dehydrogenase activity
WU22_RS05685	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
WU22_RS05720	COG2271	Major facilitator Superfamily
WU22_RS05725	COG1309	transcriptional regulator
WU22_RS05735	COG3468	outer membrane autotransporter barrel domain protein
WU22_RS05765	COG0477	Major facilitator Superfamily
WU22_RS05775	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WU22_RS05780	COG1845	cytochrome c oxidase, subunit III
WU22_RS05785	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
WU22_RS05795	COG1028	Short-chain dehydrogenase reductase Sdr
WU22_RS05815	COG0789	Transcriptional regulator
WU22_RS05840	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WU22_RS05845	COG0697	spore germination
WU22_RS05855	COG0678	peroxiredoxin activity
WU22_RS05865	COG0412	Dienelactone hydrolase
WU22_RS05875	COG0315	cyclic pyranopterin monophosphate synthase activity
WU22_RS05890	COG0521	Mo-molybdopterin cofactor biosynthetic process
WU22_RS05895	COG0303	'Molybdopterin
WU22_RS05900	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
WU22_RS05920	COG0165	Argininosuccinate lyase
WU22_RS05925	COG0668	transmembrane transport
WU22_RS05970	COG0747	negative chemotaxis
WU22_RS05975	COG0601	transmembrane transport
WU22_RS05980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WU22_RS05985	COG1162	GTPase activity
WU22_RS05990	COG0501	Belongs to the peptidase M48B family
WU22_RS05995	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
WU22_RS06005	COG3327	negative regulation of DNA-templated transcription, initiation
WU22_RS06010	COG3396	Phenylacetate-CoA oxygenase
WU22_RS06015	COG3460	Phenylacetate-CoA oxygenase
WU22_RS06020	COG3396	Phenylacetate-CoA oxygenase
WU22_RS06025	COG2151	metal-sulfur cluster biosynthetic enzyme
WU22_RS06030	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WU22_RS06040	COG1012	belongs to the aldehyde dehydrogenase family
WU22_RS06045	COG1024	Enoyl-CoA hydratase
WU22_RS06050	COG2050	protein possibly involved in aromatic compounds catabolism
WU22_RS06060	COG3539	Fimbrial protein
WU22_RS06080	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
WU22_RS06085	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
WU22_RS06085	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
WU22_RS06090	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
WU22_RS06095	COG0047	phosphoribosylformylglycinamidine synthase activity
WU22_RS06095	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WU22_RS06100	COG3210	domain, Protein
WU22_RS06100	COG3064	Membrane
WU22_RS06100	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
WU22_RS06125	COG0235	Class ii aldolase
WU22_RS06130	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
WU22_RS06135	COG0720	synthase
WU22_RS06140	COG0602	queuosine metabolic process
WU22_RS06165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WU22_RS06200	COG3181	Tripartite tricarboxylate transporter family receptor
WU22_RS06230	COG3842	ATPase activity
WU22_RS06240	COG0395	ABC-type sugar transport system, permease component
WU22_RS06270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WU22_RS06275	COG0420	3'-5' exonuclease activity
WU22_RS06320	COG0519	Catalyzes the synthesis of GMP from XMP
WU22_RS06320	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WU22_RS06335	COG3550	peptidyl-serine autophosphorylation
WU22_RS06345	COG0477	Major facilitator Superfamily
WU22_RS06360	COG1228	amidohydrolase
WU22_RS06370	COG1116	anion transmembrane transporter activity
WU22_RS06375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WU22_RS06415	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
WU22_RS06430	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
WU22_RS06460	COG2814	Major facilitator Superfamily
WU22_RS06475	COG1280	lysine exporter protein (LysE YggA)
WU22_RS06495	COG0747	negative chemotaxis
WU22_RS06500	COG0601	transmembrane transport
WU22_RS06505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WU22_RS06510	COG4172	Belongs to the ABC transporter superfamily
WU22_RS06515	COG1609	Transcriptional regulator
WU22_RS06545	COG0586	Pfam SNARE associated Golgi protein
WU22_RS06560	COG0500	methyltransferase
WU22_RS06575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WU22_RS06585	COG0756	dUTP diphosphatase activity
WU22_RS06600	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WU22_RS06605	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WU22_RS06610	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WU22_RS06615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WU22_RS06615	COG0072	phenylalanine-tRNA ligase activity
WU22_RS06620	COG0776	regulation of translation
WU22_RS06690	COG0540	Belongs to the ATCase OTCase family
WU22_RS06695	COG2974	May be involved in recombination
WU22_RS06705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU22_RS06710	COG0583	DNA-binding transcription factor activity
WU22_RS06730	COG1028	Short-chain dehydrogenase reductase Sdr
WU22_RS06745	COG3842	ATPase activity
WU22_RS06750	COG1024	Enoyl-CoA hydratase
WU22_RS06750	COG1250	3-hydroxyacyl-CoA dehydrogenase
WU22_RS06770	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WU22_RS06775	COG2137	regulation of response to DNA damage stimulus
WU22_RS06785	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
WU22_RS06795	COG0045	succinate-CoA ligase (ADP-forming) activity
WU22_RS06800	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
WU22_RS06805	COG0861	Integral membrane protein TerC family
WU22_RS06810	COG0861	Integral membrane protein TerC family
WU22_RS06815	COG0181	hydroxymethylbilane synthase activity
WU22_RS06875	COG4964	Belongs to the GSP D family
WU22_RS06905	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WU22_RS06915	COG0583	DNA-binding transcription factor activity
WU22_RS06925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WU22_RS06930	COG4311	Sarcosine oxidase, delta subunit
WU22_RS06935	COG0446	pyridine nucleotide-disulphide oxidoreductase
WU22_RS06935	COG0404	The glycine cleavage system catalyzes the degradation of glycine
WU22_RS06970	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WU22_RS06975	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WU22_RS06980	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WU22_RS06985	COG0735	belongs to the Fur family
WU22_RS06990	COG0497	DNA recombination
WU22_RS06995	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WU22_RS07000	COG1420	regulation of RNA biosynthetic process
WU22_RS07005	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WU22_RS07015	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WU22_RS07025	COG0443	Heat shock 70 kDa protein
WU22_RS07035	COG0612	Peptidase, M16
WU22_RS07055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WU22_RS07100	COG0745	RESPONSE REGULATOR receiver
WU22_RS07110	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
WU22_RS07115	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
WU22_RS07120	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
WU22_RS07135	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WU22_RS07155	COG1193	negative regulation of DNA recombination
WU22_RS07160	COG0492	ferredoxin-NADP+ reductase activity
WU22_RS07165	COG1674	ftsk spoiiie
WU22_RS07170	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
WU22_RS07175	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WU22_RS07180	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WU22_RS07205	COG3706	GGDEF domain
WU22_RS07225	COG2814	Major facilitator Superfamily
WU22_RS07255	COG3486	L-lysine 6-monooxygenase (NADPH) activity
WU22_RS07270	COG1028	Short-chain dehydrogenase reductase Sdr
WU22_RS07280	COG3022	response to hydroperoxide
WU22_RS07310	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WU22_RS07320	COG2197	response regulator
WU22_RS07325	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WU22_RS07330	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WU22_RS07335	COG0189	ligase activity
WU22_RS07345	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WU22_RS07350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WU22_RS07360	COG1764	response to oxidative stress
WU22_RS07365	COG2423	ornithine cyclodeaminase activity
WU22_RS07375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WU22_RS07380	COG0765	amino acid transport
WU22_RS07385	COG0765	amino acid transport
WU22_RS07390	COG1126	abc transporter atp-binding protein
WU22_RS07445	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WU22_RS07455	COG2944	sequence-specific DNA binding
WU22_RS07465	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
WU22_RS07470	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WU22_RS07475	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WU22_RS07480	COG0009	L-threonylcarbamoyladenylate synthase
WU22_RS07485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WU22_RS07490	COG1414	Transcriptional regulator
WU22_RS07505	COG0765	amino acid transport
WU22_RS07510	COG1126	abc transporter atp-binding protein
WU22_RS07515	COG0028	Belongs to the TPP enzyme family
WU22_RS07530	COG0028	Belongs to the TPP enzyme family
WU22_RS07535	COG0583	DNA-binding transcription factor activity
WU22_RS07540	COG4974	Belongs to the 'phage' integrase family
WU22_RS07545	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
WU22_RS07550	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
WU22_RS07565	COG1686	Belongs to the peptidase S11 family
WU22_RS07575	COG2814	Major facilitator Superfamily
WU22_RS07585	COG1074	ATP-dependent DNA helicase activity
WU22_RS07600	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WU22_RS07605	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WU22_RS07610	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WU22_RS07630	COG2321	neutral zinc metallopeptidase
WU22_RS07635	COG0009	L-threonylcarbamoyladenylate synthase
WU22_RS07680	COG3360	Dodecin
WU22_RS07685	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WU22_RS07690	COG2850	peptidyl-arginine hydroxylation
WU22_RS07695	COG3539	Fimbrial protein
WU22_RS07700	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
WU22_RS07705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WU22_RS07725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WU22_RS07730	COG0765	amino acid transport
WU22_RS07735	COG1126	abc transporter atp-binding protein
WU22_RS07740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WU22_RS07745	COG1758	RNA polymerase activity
WU22_RS07750	COG0194	GDP metabolic process
WU22_RS07755	COG3258	Cytochrome c
WU22_RS07760	COG2863	cytochrome
WU22_RS07765	COG1028	Short-chain dehydrogenase reductase Sdr
WU22_RS07770	COG0791	NLP P60 protein
WU22_RS07775	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WU22_RS07795	COG1561	YicC-like family, N-terminal region
WU22_RS07800	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
WU22_RS07815	COG0840	transmembrane signaling receptor activity
WU22_RS07820	COG2200	EAL domain
WU22_RS07820	COG2199	diguanylate cyclase activity
WU22_RS07825	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WU22_RS07835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WU22_RS07840	COG0174	glutamine synthetase
WU22_RS07850	COG2204	response regulator
WU22_RS07855	COG0583	DNA-binding transcription factor activity
WU22_RS07860	COG1741	Belongs to the pirin family
WU22_RS07865	COG1741	Belongs to the pirin family
WU22_RS07875	COG3842	ATPase activity
WU22_RS07880	COG1178	ABC-type Fe3 transport system permease component
WU22_RS07885	COG1840	ABC-type Fe3 transport system, periplasmic component
WU22_RS07895	COG0583	DNA-binding transcription factor activity
WU22_RS07905	COG0656	L-ascorbic acid biosynthetic process
WU22_RS07920	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WU22_RS07925	COG0583	DNA-binding transcription factor activity
WU22_RS07940	COG0783	Belongs to the Dps family
WU22_RS07960	COG0463	Glycosyl transferase, family 2
WU22_RS07980	COG0438	transferase activity, transferring glycosyl groups
WU22_RS07995	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
WU22_RS08020	COG0300	oxidoreductase activity
WU22_RS08065	COG0861	Integral membrane protein TerC family
WU22_RS08070	COG1028	Short-chain dehydrogenase reductase Sdr
WU22_RS08090	COG0714	Associated with various cellular activities
WU22_RS08125	COG3119	arylsulfatase activity
WU22_RS08150	COG2197	response regulator
WU22_RS08160	COG2944	sequence-specific DNA binding
WU22_RS08165	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
WU22_RS08170	COG0625	glutathione transferase activity
WU22_RS08200	COG0179	Fumarylacetoacetate (FAA) hydrolase
WU22_RS08205	COG1028	Short-chain dehydrogenase reductase Sdr
WU22_RS08250	COG0431	NADPH-dependent FMN reductase
WU22_RS08280	COG1028	Short-chain dehydrogenase reductase Sdr
WU22_RS08285	COG0583	DNA-binding transcription factor activity
WU22_RS08300	COG3181	Tripartite tricarboxylate transporter family receptor
WU22_RS08305	COG2111	Na H antiporter
WU22_RS08305	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WU22_RS08310	COG1006	Multisubunit Na H antiporter MnhC subunit
WU22_RS08315	COG0651	ATP synthesis coupled electron transport
WU22_RS08320	COG1863	multisubunit Na H antiporter MnhE subunit
WU22_RS08325	COG2212	antiporter activity
WU22_RS08350	COG0590	tRNA wobble adenosine to inosine editing
WU22_RS08355	COG1619	proteins homologs of microcin C7 resistance protein MccF
WU22_RS08360	COG1024	Enoyl-CoA hydratase
WU22_RS08375	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
WU22_RS08380	COG0488	(ABC) transporter
WU22_RS08415	COG1017	nitric oxide dioxygenase activity
WU22_RS08415	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WU22_RS08420	COG1959	2 iron, 2 sulfur cluster binding
WU22_RS08425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WU22_RS08445	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WU22_RS08450	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WU22_RS08455	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WU22_RS08460	COG0084	hydrolase, TatD family'
WU22_RS08475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WU22_RS08485	COG1126	abc transporter atp-binding protein
WU22_RS08490	COG0010	Belongs to the arginase family
WU22_RS08495	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
WU22_RS08500	COG1012	belongs to the aldehyde dehydrogenase family
WU22_RS08510	COG0028	Belongs to the TPP enzyme family
WU22_RS08520	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
WU22_RS08520	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
WU22_RS08530	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
WU22_RS08545	COG3189	MarR family transcriptional regulator
WU22_RS08550	COG2010	Cytochrome c
WU22_RS08575	COG4336	lyase activity
WU22_RS08585	COG2205	protein histidine kinase activity
WU22_RS08585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WU22_RS08590	COG2197	response regulator
WU22_RS08595	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
WU22_RS08595	COG3210	domain, Protein
WU22_RS08595	COG3064	Membrane
WU22_RS08605	COG3121	Chaperone
WU22_RS08610	COG3188	usher protein
WU22_RS08615	COG3539	Fimbrial protein
WU22_RS08620	COG2831	hemolysin activation secretion protein
WU22_RS08635	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
WU22_RS08660	COG0583	DNA-binding transcription factor activity
WU22_RS08685	COG0668	transmembrane transport
WU22_RS08705	COG0483	inositol monophosphate 1-phosphatase activity
WU22_RS08710	COG1253	flavin adenine dinucleotide binding
WU22_RS08715	COG1968	undecaprenyl-diphosphatase activity
WU22_RS08720	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WU22_RS08735	COG0215	cysteine-tRNA ligase activity
WU22_RS08745	COG0825	malonyl-CoA metabolic process
WU22_RS08755	COG0037	tRNA processing
WU22_RS08760	COG0527	aspartate kinase activity
WU22_RS08785	COG1250	3-hydroxyacyl-CoA dehydrogenase
WU22_RS08790	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
WU22_RS08790	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
WU22_RS08805	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WU22_RS08810	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
WU22_RS08815	COG1028	Short-chain dehydrogenase reductase Sdr
WU22_RS08825	COG0583	DNA-binding transcription factor activity
WU22_RS08855	COG3842	ATPase activity
WU22_RS08865	COG0446	pyridine nucleotide-disulphide oxidoreductase
WU22_RS08865	COG1902	pentaerythritol trinitrate reductase activity
WU22_RS08870	COG1414	Transcriptional regulator
WU22_RS08875	COG1832	CoA-binding protein
WU22_RS08885	COG0251	oxidation-reduction process
WU22_RS08910	COG1902	pentaerythritol trinitrate reductase activity
WU22_RS08920	COG1215	transferase activity, transferring glycosyl groups
WU22_RS08925	COG1649	PFAM Uncharacterised BCR, COG1649
WU22_RS08925	COG0726	polysaccharide deacetylase
WU22_RS08945	COG1846	Transcriptional regulator
WU22_RS08950	COG2197	response regulator
WU22_RS08965	COG0166	Belongs to the GPI family
WU22_RS08970	COG1045	serine acetyltransferase
WU22_RS08980	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
WU22_RS08985	COG0483	inositol monophosphate 1-phosphatase activity
WU22_RS08990	COG1012	belongs to the aldehyde dehydrogenase family
WU22_RS08995	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
WU22_RS09010	COG0210	DNA helicase
WU22_RS09015	COG0598	Magnesium transport protein CorA
WU22_RS09025	COG0747	negative chemotaxis
WU22_RS09030	COG0601	transmembrane transport
WU22_RS09035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WU22_RS09040	COG4172	Belongs to the ABC transporter superfamily
WU22_RS09045	COG1846	Transcriptional regulator
WU22_RS09095	COG4964	Belongs to the GSP D family
WU22_RS09135	COG2204	response regulator
WU22_RS09150	COG1595	DNA-templated transcription, initiation
WU22_RS09160	COG3474	cytochrome
WU22_RS09165	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WU22_RS09180	COG3384	dioxygenase
WU22_RS09185	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
WU22_RS09210	COG2885	chlorophyll binding
WU22_RS09245	COG0697	spore germination
WU22_RS09250	COG0730	response to heat
WU22_RS09270	COG0583	DNA-binding transcription factor activity
WU22_RS09275	COG0427	acetyl-CoA hydrolase
WU22_RS09320	COG3468	outer membrane autotransporter barrel domain protein
WU22_RS09325	COG0424	maF-like protein
WU22_RS09330	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
WU22_RS09335	COG0799	negative regulation of ribosome biogenesis
WU22_RS09340	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
WU22_RS09345	COG0408	coproporphyrinogen oxidase activity
WU22_RS09350	COG0151	Belongs to the GarS family
WU22_RS09355	COG0217	transcriptional regulatory protein
WU22_RS09360	COG0433	COG0433 Predicted ATPase
WU22_RS09365	COG1115	amino acid carrier protein
WU22_RS09370	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WU22_RS09380	COG1012	belongs to the aldehyde dehydrogenase family
WU22_RS09405	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
WU22_RS09420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WU22_RS09430	COG0747	negative chemotaxis
WU22_RS09440	COG0473	3-isopropylmalate dehydrogenase activity
WU22_RS09445	COG2814	Major facilitator Superfamily
WU22_RS09450	COG1566	PFAM secretion protein HlyD family protein
WU22_RS09460	COG1846	Transcriptional regulator
WU22_RS09470	COG0697	spore germination
WU22_RS09480	COG0501	Belongs to the peptidase M48B family
WU22_RS09500	COG0583	DNA-binding transcription factor activity
WU22_RS09505	COG3842	ATPase activity
WU22_RS09510	COG1178	ABC-type Fe3 transport system permease component
WU22_RS09515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WU22_RS09520	COG1840	ABC-type Fe3 transport system, periplasmic component
WU22_RS09525	COG0492	ferredoxin-NADP+ reductase activity
WU22_RS09545	COG2233	PERMEase
WU22_RS09550	COG0840	transmembrane signaling receptor activity
WU22_RS09555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WU22_RS09585	COG4789	Type iii secretion
WU22_RS09650	COG4669	(LipO)protein
WU22_RS09685	COG4790	Type iii secretion
WU22_RS09690	COG4794	Type iii secretion
WU22_RS09695	COG4791	protein targeting
WU22_RS09700	COG4792	protein secretion
WU22_RS09715	COG1595	DNA-templated transcription, initiation
WU22_RS09735	COG2770	Histidine kinase
WU22_RS09735	COG2208	phosphoserine phosphatase activity
WU22_RS09745	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WU22_RS09750	COG2172	sigma factor antagonist activity
WU22_RS09755	COG1366	Belongs to the anti-sigma-factor antagonist family
WU22_RS09760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WU22_RS09790	COG2358	TRAP transporter, solute receptor (TAXI family
WU22_RS09795	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WU22_RS09825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WU22_RS09835	COG2252	PERMEase
WU22_RS09840	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WU22_RS09850	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
WU22_RS09855	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WU22_RS09885	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WU22_RS09890	COG0789	Transcriptional regulator
WU22_RS09900	COG0678	peroxiredoxin activity
WU22_RS09900	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
WU22_RS09910	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
WU22_RS09915	COG0584	glycerophosphoryl diester phosphodiesterase
WU22_RS09920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WU22_RS09930	COG4181	ATPase activity
WU22_RS09945	COG2823	Periplasmic or secreted lipoprotein
WU22_RS09955	COG3237	CsbD-like
WU22_RS09960	COG1181	Belongs to the D-alanine--D-alanine ligase family
WU22_RS09960	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WU22_RS09965	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WU22_RS09965	COG0189	ligase activity
WU22_RS09985	COG2833	Protein of unknown function (DUF455)
WU22_RS09990	COG2951	lytic endotransglycosylase activity
WU22_RS10010	COG1522	sequence-specific DNA binding
WU22_RS10020	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WU22_RS10025	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WU22_RS10030	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WU22_RS10035	COG0196	riboflavin kinase activity
WU22_RS10040	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WU22_RS10060	COG0210	DNA helicase
WU22_RS10065	COG4771	TonB-dependent receptor
WU22_RS10070	COG0488	(ABC) transporter
WU22_RS10075	COG2890	protein-(glutamine-N5) methyltransferase activity
WU22_RS10080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WU22_RS10085	COG2171	N-acyltransferase activity
WU22_RS10120	COG1278	Cold shock
WU22_RS10140	COG0544	peptidyl-prolyl cis-trans isomerase activity
WU22_RS10145	COG0740	serine-type endopeptidase activity
WU22_RS10150	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WU22_RS10155	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WU22_RS10160	COG0583	DNA-binding transcription factor activity
WU22_RS10165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU22_RS10180	COG1024	Enoyl-CoA hydratase
WU22_RS10190	COG0183	Belongs to the thiolase family
WU22_RS10195	COG1028	Short-chain dehydrogenase reductase Sdr
WU22_RS10200	COG1960	acyl-CoA dehydrogenase activity
WU22_RS10215	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
WU22_RS10245	COG3468	outer membrane autotransporter barrel domain protein
WU22_RS10250	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WU22_RS10260	COG0556	nucleotide-excision repair
WU22_RS10265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
WU22_RS10275	COG1104	cysteine desulfurase activity
WU22_RS10280	COG0822	iron-sulfur transferase activity
WU22_RS10285	COG0316	Belongs to the HesB IscA family
WU22_RS10290	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
WU22_RS10295	COG0443	Heat shock 70 kDa protein
WU22_RS10300	COG0633	Ferredoxin
WU22_RS10320	COG1024	Enoyl-CoA hydratase
WU22_RS10335	COG3395	kinase activity
WU22_RS10340	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
WU22_RS10355	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
WU22_RS10365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WU22_RS10390	COG0747	negative chemotaxis
WU22_RS10395	COG0601	transmembrane transport
WU22_RS10400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WU22_RS10405	COG4172	Belongs to the ABC transporter superfamily
WU22_RS10410	COG0154	amidase activity
WU22_RS10455	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WU22_RS10460	COG0425	Belongs to the sulfur carrier protein TusA family
WU22_RS10475	COG0228	four-way junction DNA binding
WU22_RS10480	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WU22_RS10485	COG0336	Belongs to the RNA methyltransferase TrmD family
WU22_RS10490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WU22_RS10510	COG0642	Histidine kinase
WU22_RS10525	COG0525	valine-tRNA ligase activity
WU22_RS10530	COG0105	UTP biosynthetic process
WU22_RS10535	COG0820	rRNA (adenine-C2-)-methyltransferase activity
WU22_RS10545	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
WU22_RS10550	COG0124	histidyl-tRNA synthetase
WU22_RS10555	COG2976	Protein conserved in bacteria
WU22_RS10560	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WU22_RS10565	COG1160	GTP binding
WU22_RS10570	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
WU22_RS10575	COG1923	regulation of RNA biosynthetic process
WU22_RS10580	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WU22_RS10585	COG0330	HflC and HflK could
WU22_RS10590	COG0330	HflC and HflK could
WU22_RS10595	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
WU22_RS10600	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
WU22_RS10605	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
WU22_RS10610	COG0828	Belongs to the bacterial ribosomal protein bS21 family
WU22_RS10620	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WU22_RS10655	COG0628	permease
WU22_RS10660	COG0842	Transport permease protein
WU22_RS10665	COG1131	(ABC) transporter
WU22_RS10735	COG0156	8-amino-7-oxononanoate synthase activity
WU22_RS10745	COG4106	trans-aconitate 2-methyltransferase activity
WU22_RS10745	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
WU22_RS10750	COG1380	Effector of murein hydrolase LrgA
WU22_RS10770	COG3284	Transcriptional regulator
WU22_RS10775	COG1012	belongs to the aldehyde dehydrogenase family
WU22_RS10790	COG2733	membrane
WU22_RS10795	COG0583	DNA-binding transcription factor activity
WU22_RS10800	COG0384	phenazine biosynthesis protein PhzF
WU22_RS10805	COG5507	3-demethylubiquinone-9 3-methyltransferase
WU22_RS10810	COG2169	Transcriptional regulator
WU22_RS10840	COG0659	secondary active sulfate transmembrane transporter activity
WU22_RS10865	COG1132	(ABC) transporter
WU22_RS10910	COG2207	Transcriptional regulator
WU22_RS11045	COG2346	COG2346, Truncated hemoglobins
WU22_RS11090	COG0183	Belongs to the thiolase family
WU22_RS11105	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU22_RS11110	COG0633	Ferredoxin
WU22_RS11120	COG1024	Enoyl-CoA hydratase
WU22_RS11130	COG4638	Rieske (2fe-2S)
WU22_RS11140	COG0559	Belongs to the binding-protein-dependent transport system permease family
WU22_RS11160	COG2224	Isocitrate lyase
WU22_RS11165	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WU22_RS11165	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WU22_RS11180	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WU22_RS11185	COG0322	excinuclease ABC activity
WU22_RS11190	COG1472	Belongs to the glycosyl hydrolase 3 family
WU22_RS11195	COG0736	holo-[acyl-carrier-protein] synthase activity
WU22_RS11200	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
WU22_RS11210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WU22_RS11215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WU22_RS11240	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
WU22_RS11255	COG2032	superoxide dismutase activity
WU22_RS11270	COG1024	Enoyl-CoA hydratase
WU22_RS11280	COG1802	Transcriptional regulator
WU22_RS11290	COG0183	Belongs to the thiolase family
WU22_RS11295	COG1942	4-Oxalocrotonate Tautomerase
WU22_RS11305	COG4176	ABC-type proline glycine betaine transport system permease component
WU22_RS11320	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WU22_RS11325	COG2814	Major facilitator Superfamily
WU22_RS11330	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WU22_RS11335	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WU22_RS11365	COG2814	Major facilitator Superfamily
WU22_RS11370	COG0495	leucyl-tRNA aminoacylation
WU22_RS11385	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
WU22_RS11395	COG0154	amidase activity
WU22_RS11400	COG1250	3-hydroxyacyl-CoA dehydrogenase
WU22_RS11450	COG1530	ribonuclease E activity
WU22_RS11455	COG0077	Prephenate dehydratase
WU22_RS11470	COG1132	(ABC) transporter
WU22_RS11475	COG0859	PFAM glycosyl transferase family 9
WU22_RS11500	COG2194	sulfuric ester hydrolase activity
WU22_RS11505	COG0438	transferase activity, transferring glycosyl groups
WU22_RS11510	COG0463	Glycosyl transferase, family 2
WU22_RS11515	COG0726	polysaccharide deacetylase
WU22_RS11520	COG0438	transferase activity, transferring glycosyl groups
WU22_RS11535	COG1643	Atp-dependent helicase
WU22_RS11540	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WU22_RS11540	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
WU22_RS11545	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
WU22_RS11555	COG0704	Plays a role in the regulation of phosphate uptake
WU22_RS11560	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
WU22_RS11565	COG1960	acyl-CoA dehydrogenase activity
WU22_RS11590	COG1177	transmembrane transport
WU22_RS11595	COG1176	ABC-type spermidine putrescine transport system, permease component I
WU22_RS11600	COG3842	ATPase activity
WU22_RS11605	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
WU22_RS11620	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
WU22_RS11625	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
WU22_RS11635	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
WU22_RS11635	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
WU22_RS11655	COG0372	Belongs to the citrate synthase family
WU22_RS11660	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
WU22_RS11665	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WU22_RS11670	COG1053	succinate dehydrogenase
WU22_RS11675	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
WU22_RS11680	COG2009	succinate dehydrogenase
WU22_RS11685	COG2188	Transcriptional regulator
WU22_RS11690	COG0039	L-malate dehydrogenase activity
WU22_RS11720	COG1981	membrane
WU22_RS11745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WU22_RS11755	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
WU22_RS11785	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
WU22_RS11790	COG0148	phosphopyruvate hydratase activity
WU22_RS11800	COG2877	3-deoxy-8-phosphooctulonate synthase activity
WU22_RS11805	COG0504	CTP synthase activity
WU22_RS11830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WU22_RS11840	COG0747	negative chemotaxis
WU22_RS11845	COG4172	Belongs to the ABC transporter superfamily
WU22_RS11850	COG1446	asparaginase
WU22_RS11880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WU22_RS11895	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
WU22_RS11900	COG0697	spore germination
WU22_RS11905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WU22_RS11915	COG3193	protein, possibly involved in utilization of glycolate and propanediol
WU22_RS11920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WU22_RS11925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WU22_RS11930	COG0791	NLP P60 protein
WU22_RS11945	COG0583	DNA-binding transcription factor activity
WU22_RS11960	COG0583	DNA-binding transcription factor activity
WU22_RS11970	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WU22_RS11985	COG0670	Belongs to the BI1 family
WU22_RS11990	COG3181	Tripartite tricarboxylate transporter family receptor
WU22_RS12000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
WU22_RS12010	COG1381	Involved in DNA repair and RecF pathway recombination
WU22_RS12015	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WU22_RS12020	COG0571	ribonuclease III activity
WU22_RS12025	COG0681	Belongs to the peptidase S26 family
WU22_RS12030	COG0481	GTPase activity
WU22_RS12035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WU22_RS12060	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WU22_RS12065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WU22_RS12080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WU22_RS12085	COG0416	fatty acid biosynthetic process
WU22_RS12090	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WU22_RS12095	COG1399	metal-binding, possibly nucleic acid-binding protein
WU22_RS12100	COG0424	maF-like protein
WU22_RS12110	COG3023	N-Acetylmuramoyl-L-alanine amidase
WU22_RS12125	COG3022	response to hydroperoxide
WU22_RS12140	COG0135	phosphoribosylanthranilate isomerase activity
WU22_RS12155	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
WU22_RS12160	COG0101	tRNA pseudouridine synthase activity
WU22_RS12170	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WU22_RS12175	COG0473	3-isopropylmalate dehydrogenase activity
WU22_RS12180	COG0066	3-isopropylmalate dehydratase activity
WU22_RS12185	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
WU22_RS12195	COG1122	ATPase activity
WU22_RS12225	COG0437	4 iron, 4 sulfur cluster binding
WU22_RS12230	COG0243	molybdopterin cofactor binding
WU22_RS12230	COG3383	formate dehydrogenase (NAD+) activity
WU22_RS12260	COG0489	protein tyrosine kinase activity
WU22_RS12265	COG0746	molybdenum cofactor guanylyltransferase activity
WU22_RS12270	COG0303	'Molybdopterin
WU22_RS12275	COG1763	Mo-molybdopterin cofactor biosynthetic process
WU22_RS12285	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
WU22_RS12290	COG5001	Diguanylate cyclase
WU22_RS12310	COG3842	ATPase activity
WU22_RS12320	COG0406	alpha-ribazole phosphatase activity
WU22_RS12330	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WU22_RS12335	COG0505	Belongs to the CarA family
WU22_RS12340	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WU22_RS12375	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
WU22_RS12380	COG1960	acyl-CoA dehydrogenase activity
WU22_RS12390	COG2867	negative regulation of translational initiation
WU22_RS12400	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WU22_RS12405	COG3706	GGDEF domain
WU22_RS12410	COG0330	HflC and HflK could
WU22_RS12425	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WU22_RS12425	COG0519	Catalyzes the synthesis of GMP from XMP
WU22_RS12435	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
WU22_RS12440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WU22_RS12445	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WU22_RS12450	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WU22_RS12460	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WU22_RS12465	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WU22_RS12470	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
WU22_RS12475	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WU22_RS12480	COG0750	zinc metalloprotease
WU22_RS12485	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
WU22_RS12495	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WU22_RS12500	COG0233	cytoplasmic translational termination
WU22_RS12505	COG0528	UMP kinase activity
WU22_RS12510	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WU22_RS12515	COG0052	Belongs to the universal ribosomal protein uS2 family
WU22_RS12520	COG0024	Methionine aminopeptidase
WU22_RS12525	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
WU22_RS12555	COG0285	dihydrofolate synthase activity
WU22_RS12590	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
WU22_RS12600	COG1677	Flagellar hook-basal body complex protein FliE
WU22_RS12610	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WU22_RS12615	COG1317	bacterial-type flagellum organization
WU22_RS12620	COG1157	protein secretion by the type III secretion system
WU22_RS12645	COG1580	Controls the rotational direction of flagella during chemotaxis
WU22_RS12665	COG1338	Plays a role in the flagellum-specific transport system
WU22_RS12685	COG0840	transmembrane signaling receptor activity
WU22_RS12690	COG0840	transmembrane signaling receptor activity
WU22_RS12695	COG0840	transmembrane signaling receptor activity
WU22_RS12705	COG1256	bacterial-type flagellum assembly
WU22_RS12715	COG1706	bacterial-type flagellum-dependent cell motility
WU22_RS12720	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
WU22_RS12735	COG1749	Flagellar hook protein flgE
WU22_RS12745	COG1558	bacterial-type flagellum-dependent cell motility
WU22_RS12750	COG1815	bacterial-type flagellum-dependent cell motility
WU22_RS12790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WU22_RS12795	COG0765	amino acid transport
WU22_RS12800	COG1126	abc transporter atp-binding protein
WU22_RS12815	COG4948	Mandelate Racemase Muconate Lactonizing
WU22_RS12820	COG3181	Tripartite tricarboxylate transporter family receptor
WU22_RS12830	COG0066	3-isopropylmalate dehydratase activity
WU22_RS12845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU22_RS12855	COG3181	Tripartite tricarboxylate transporter family receptor
WU22_RS12865	COG1802	Transcriptional regulator
WU22_RS12880	COG0583	DNA-binding transcription factor activity
WU22_RS12900	COG1695	Transcriptional regulator
WU22_RS12910	COG3568	Endonuclease Exonuclease Phosphatase
WU22_RS12915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WU22_RS12930	COG0392	lysyltransferase activity
WU22_RS12970	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
WU22_RS12980	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
WU22_RS13000	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
WU22_RS13030	COG0667	Aldo Keto reductase
WU22_RS13045	COG2259	Doxx family
WU22_RS13075	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU22_RS13095	COG0386	Belongs to the glutathione peroxidase family
WU22_RS13100	COG0625	glutathione transferase activity
WU22_RS13125	COG0688	phosphatidylethanolamine metabolic process
WU22_RS13135	COG1464	Belongs to the NlpA lipoprotein family
WU22_RS13150	COG2363	Small membrane protein
WU22_RS13175	COG3842	ATPase activity
WU22_RS13180	COG0395	ABC-type sugar transport system, permease component
WU22_RS13185	COG1175	transmembrane transport
WU22_RS13190	COG1653	transport
WU22_RS13200	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
WU22_RS13215	COG0559	Belongs to the binding-protein-dependent transport system permease family
WU22_RS13235	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
WU22_RS13250	COG0697	spore germination
WU22_RS13260	COG2311	Membrane
WU22_RS13285	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
WU22_RS13295	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
WU22_RS13300	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
WU22_RS13305	COG1760	l-serine dehydratase
WU22_RS13310	COG1283	sodium-dependent phosphate transmembrane transporter activity
WU22_RS13315	COG0412	Dienelactone hydrolase
WU22_RS13330	COG1611	Belongs to the LOG family
WU22_RS13350	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WU22_RS13355	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WU22_RS13360	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WU22_RS13365	COG2251	uridine kinase activity
WU22_RS13365	COG0195	Participates in both transcription termination and antitermination
WU22_RS13370	COG0779	Required for maturation of 30S ribosomal subunits
WU22_RS13375	COG1187	pseudouridine synthase activity
WU22_RS13380	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
WU22_RS13390	COG0583	DNA-binding transcription factor activity
WU22_RS13400	COG0523	cobalamin synthesis protein
WU22_RS13420	COG0625	glutathione transferase activity
WU22_RS13425	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
WU22_RS13430	COG1047	Peptidyl-prolyl cis-trans
WU22_RS13435	COG2003	Belongs to the UPF0758 family
WU22_RS13440	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
WU22_RS13445	COG3483	tryptophan 2,3-dioxygenase activity
WU22_RS13450	COG0254	rRNA binding
WU22_RS13460	COG0534	Mate efflux family protein
WU22_RS13480	COG2304	oxidoreductase activity
WU22_RS13500	COG1028	Short-chain dehydrogenase reductase Sdr
WU22_RS13505	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WU22_RS13510	COG1562	ergosterol biosynthetic process
WU22_RS13515	COG1562	ergosterol biosynthetic process
WU22_RS13520	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
WU22_RS13520	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
WU22_RS13525	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
WU22_RS13535	COG0842	Transport permease protein
WU22_RS13540	COG1131	(ABC) transporter
WU22_RS13560	COG1477	protein flavinylation
WU22_RS13575	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
WU22_RS13590	COG5564	TIM-barrel signal transduction protein
WU22_RS13595	COG5441	Belongs to the UPF0261 family
WU22_RS13605	COG3468	outer membrane autotransporter barrel domain protein
WU22_RS13610	COG3468	outer membrane autotransporter barrel domain protein
WU22_RS13625	COG0542	response to heat
WU22_RS13630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WU22_RS13645	COG0494	nUDIX hydrolase
WU22_RS13650	COG3530	Putative quorum-sensing-regulated virulence factor
WU22_RS13660	COG1595	DNA-templated transcription, initiation
WU22_RS13665	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WU22_RS13700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WU22_RS13705	COG0765	amino acid transport
WU22_RS13710	COG0765	amino acid transport
WU22_RS13735	COG2988	succinylglutamate desuccinylase activity
WU22_RS13760	COG3181	Tripartite tricarboxylate transporter family receptor
WU22_RS13765	COG2084	Dehydrogenase
WU22_RS13780	COG1619	proteins homologs of microcin C7 resistance protein MccF
WU22_RS13795	COG2814	Major facilitator Superfamily
WU22_RS13805	COG0583	DNA-binding transcription factor activity
WU22_RS13845	COG0672	)-iron permease
WU22_RS13860	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
WU22_RS13865	COG1028	Short-chain dehydrogenase reductase Sdr
WU22_RS13870	COG3243	poly(R)-hydroxyalkanoic acid synthase
WU22_RS13880	COG0564	pseudouridine synthase activity
WU22_RS13890	COG1199	ATP-dependent helicase activity
WU22_RS13895	COG2183	response to ionizing radiation
WU22_RS13900	COG0180	Tryptophanyl-tRNA synthetase
WU22_RS13925	COG3181	Tripartite tricarboxylate transporter family receptor
WU22_RS13935	COG0583	DNA-binding transcription factor activity
WU22_RS13940	COG1028	Short-chain dehydrogenase reductase Sdr
WU22_RS13945	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
WU22_RS13950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WU22_RS13955	COG0508	dehydrogenase complex catalyzes the overall conversion of
WU22_RS13960	COG0567	Dehydrogenase, E1 component
WU22_RS13970	COG1522	sequence-specific DNA binding
WU22_RS13980	COG0280	phosphate acetyltransferase
WU22_RS13980	COG0281	malic enzyme
WU22_RS13985	COG3539	Fimbrial protein
WU22_RS14000	COG0613	PHP domain protein
WU22_RS14010	COG2333	competence protein COMEC
WU22_RS14010	COG0658	competence protein
WU22_RS14040	COG0084	hydrolase, TatD family'
WU22_RS14045	COG1136	(ABC) transporter
WU22_RS14060	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WU22_RS14070	COG1028	Short-chain dehydrogenase reductase Sdr
WU22_RS14075	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
WU22_RS14090	COG1022	Amp-dependent synthetase and ligase
WU22_RS14125	COG2205	protein histidine kinase activity
WU22_RS14130	COG0745	RESPONSE REGULATOR receiver
WU22_RS14135	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
WU22_RS14145	COG1295	ribonuclease BN
WU22_RS14160	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WU22_RS14190	COG1534	Rna-binding protein
WU22_RS14195	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
WU22_RS14200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WU22_RS14210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WU22_RS14220	COG0248	Ppx GppA phosphatase
WU22_RS14245	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
WU22_RS14265	COG2732	(Barnase) inhibitor
WU22_RS14275	COG0281	malic enzyme
WU22_RS14275	COG0280	phosphate acetyltransferase
WU22_RS14285	COG0436	Aminotransferase
WU22_RS14290	COG0741	lytic transglycosylase activity
WU22_RS14295	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
WU22_RS14320	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WU22_RS14320	COG1648	precorrin-2 dehydrogenase activity
WU22_RS14325	COG3468	outer membrane autotransporter barrel domain protein
WU22_RS14335	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
WU22_RS14340	COG2027	D-alanyl-D-alanine carboxypeptidase
WU22_RS14345	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
WU22_RS14350	COG0343	queuine tRNA-ribosyltransferase activity
WU22_RS14355	COG1862	Preprotein translocase
WU22_RS14360	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WU22_RS14365	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WU22_RS14380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WU22_RS14385	COG1702	phosphate starvation-inducible protein PhoH
WU22_RS14390	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WU22_RS14395	COG4535	Mg2 and Co2 transporter CorC
WU22_RS14405	COG0667	Aldo Keto reductase
WU22_RS14430	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
WU22_RS14435	COG0745	RESPONSE REGULATOR receiver
WU22_RS14440	COG2201	protein-glutamate methylesterase activity
WU22_RS14450	COG0840	transmembrane signaling receptor activity
WU22_RS14465	COG0745	RESPONSE REGULATOR receiver
WU22_RS14500	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WU22_RS14510	COG0739	heme binding
WU22_RS14520	COG0521	Mo-molybdopterin cofactor biosynthetic process
WU22_RS14530	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
WU22_RS14565	COG0625	glutathione transferase activity
WU22_RS14580	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WU22_RS14585	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WU22_RS14590	COG0126	phosphoglycerate kinase activity
WU22_RS14595	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WU22_RS14600	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
WU22_RS14605	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WU22_RS14615	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WU22_RS14620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WU22_RS14625	COG0508	dehydrogenase complex catalyzes the overall conversion of
WU22_RS14630	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
WU22_RS14640	COG4566	intracellular signal transduction
WU22_RS14645	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WU22_RS14650	COG0339	signal peptide processing
WU22_RS14655	COG1999	signal sequence binding
WU22_RS14675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WU22_RS14685	COG1187	pseudouridine synthase activity
WU22_RS14690	COG3161	chorismate lyase activity
WU22_RS14695	COG2814	Major facilitator Superfamily
WU22_RS14705	COG0667	Aldo Keto reductase
WU22_RS14720	COG0335	large ribosomal subunit rRNA binding
WU22_RS14750	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
WU22_RS14755	COG4208	sulfate ABC transporter
WU22_RS14760	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
WU22_RS14775	COG0450	alkyl hydroperoxide reductase
WU22_RS14780	COG1960	acyl-CoA dehydrogenase activity
WU22_RS14795	COG0123	including yeast histone deacetylase and acetoin utilization protein
WU22_RS14800	COG2951	lytic endotransglycosylase activity
WU22_RS14815	COG1596	polysaccharide export
WU22_RS14815	COG1555	photosystem II stabilization
WU22_RS14820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WU22_RS14825	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
WU22_RS14830	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
WU22_RS14850	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
WU22_RS14855	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
WU22_RS14860	COG0287	Prephenate dehydrogenase
WU22_RS14870	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
WU22_RS14885	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WU22_RS14895	COG2814	Major facilitator Superfamily
WU22_RS14920	COG0583	DNA-binding transcription factor activity
WU22_RS14960	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WU22_RS14975	COG0667	Aldo Keto reductase
WU22_RS14985	COG5265	(ABC) transporter
WU22_RS15030	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WU22_RS15035	COG0439	Biotin carboxylase
WU22_RS15040	COG2188	Transcriptional regulator
WU22_RS15065	COG0511	ligase activity, forming carbon-carbon bonds
WU22_RS15075	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WU22_RS15095	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
WU22_RS15115	COG0500	methyltransferase
WU22_RS15120	COG5265	(ABC) transporter
WU22_RS15135	COG0028	Belongs to the TPP enzyme family
WU22_RS15140	COG0440	acetolactate synthase activity
WU22_RS15145	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
WU22_RS15150	COG1183	phosphatidylcholine synthase activity
WU22_RS15165	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WU22_RS15170	COG1185	polyribonucleotide nucleotidyltransferase activity
WU22_RS15185	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WU22_RS15205	COG0149	triose-phosphate isomerase activity
WU22_RS15210	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WU22_RS15220	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
WU22_RS15230	COG3799	methylaspartate ammonia-lyase activity
WU22_RS15265	COG0583	DNA-binding transcription factor activity
WU22_RS15270	COG0626	cystathionine gamma-synthase activity
WU22_RS15275	COG3608	succinylglutamate desuccinylase aspartoacylase
WU22_RS15295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WU22_RS15315	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
WU22_RS15330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WU22_RS15335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WU22_RS15340	COG1733	regulation of RNA biosynthetic process
WU22_RS15350	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
WU22_RS15355	COG0583	DNA-binding transcription factor activity
WU22_RS15360	COG1597	lipid kinase activity
WU22_RS15370	COG0671	phosphoesterase, PA-phosphatase related
WU22_RS15395	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
WU22_RS15400	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WU22_RS15405	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WU22_RS15410	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WU22_RS15415	COG0649	NAD binding
WU22_RS15420	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
WU22_RS15430	COG1034	ATP synthesis coupled electron transport
WU22_RS15435	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WU22_RS15440	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WU22_RS15450	COG0713	ATP synthesis coupled electron transport
WU22_RS15465	COG1007	ATP synthesis coupled electron transport
WU22_RS15475	COG4774	siderophore transport
WU22_RS15480	COG4774	siderophore transport
WU22_RS15495	COG0028	Belongs to the TPP enzyme family
WU22_RS15500	COG3181	Tripartite tricarboxylate transporter family receptor
WU22_RS15505	COG0583	DNA-binding transcription factor activity
WU22_RS15510	COG0560	Phosphoserine phosphatase
WU22_RS15515	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WU22_RS15520	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WU22_RS15525	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
WU22_RS15535	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
WU22_RS15540	COG0308	aminopeptidase N
WU22_RS15560	COG0028	Belongs to the TPP enzyme family
WU22_RS15580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WU22_RS15590	COG0318	PFAM AMP-dependent synthetase and ligase
WU22_RS15600	COG1802	Transcriptional regulator
WU22_RS15610	COG1802	Transcriptional regulator
WU22_RS15620	COG1028	Short-chain dehydrogenase reductase Sdr
WU22_RS15640	COG1126	abc transporter atp-binding protein
WU22_RS15645	COG0765	amino acid transport
WU22_RS15650	COG0765	amino acid transport
WU22_RS15665	COG1538	Outer membrane efflux protein
WU22_RS15670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WU22_RS15675	COG2274	protein secretion by the type I secretion system
WU22_RS15680	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
WU22_RS15690	COG2994	toxin metabolic process
WU22_RS15705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WU22_RS15710	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
WU22_RS15720	COG0583	DNA-binding transcription factor activity
WU22_RS15730	COG0142	geranyltranstransferase activity
WU22_RS15740	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WU22_RS15745	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WU22_RS15750	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WU22_RS15755	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
WU22_RS15800	COG3712	iron ion homeostasis
WU22_RS15805	COG4774	siderophore transport
WU22_RS15810	COG2353	YceI-like domain
WU22_RS15825	COG0019	diaminopimelate decarboxylase activity
WU22_RS15845	COG0747	negative chemotaxis
WU22_RS15850	COG0601	transmembrane transport
WU22_RS15855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WU22_RS15865	COG0154	amidase activity
WU22_RS15870	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WU22_RS15895	COG2154	pterin-4-alpha-carbinolamine dehydratase
WU22_RS15905	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
WU22_RS15915	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
WU22_RS15920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WU22_RS15925	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WU22_RS15930	COG1929	Belongs to the glycerate kinase type-1 family
WU22_RS15935	COG0469	pyruvate kinase activity
WU22_RS15940	COG0700	Nucleoside recognition
WU22_RS15975	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
WU22_RS15980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WU22_RS15995	COG0823	Involved in the tonB-independent uptake of proteins
WU22_RS16005	COG0848	biopolymer transport protein
WU22_RS16010	COG0811	peptide transport
WU22_RS16015	COG0824	Thioesterase
WU22_RS16020	COG0442	prolyl-tRNA aminoacylation
WU22_RS16025	COG0494	nUDIX hydrolase
WU22_RS16040	COG2135	peptidase activity
WU22_RS16110	COG1196	nuclear chromosome segregation
WU22_RS16255	COG1464	Belongs to the NlpA lipoprotein family
WU22_RS16285	COG4211	Belongs to the binding-protein-dependent transport system permease family
WU22_RS16295	COG0154	amidase activity
WU22_RS16300	COG0288	reversible hydration of carbon dioxide
WU22_RS16320	COG0514	ATP-dependent DNA helicase (RecQ)
WU22_RS16325	COG2255	four-way junction helicase activity
WU22_RS16340	COG0632	four-way junction helicase activity
WU22_RS16345	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
WU22_RS16365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WU22_RS16375	COG0006	proline dipeptidase activity
WU22_RS16400	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
WU22_RS16415	COG4783	chaperone-mediated protein folding
WU22_RS16420	COG0429	hydrolase of the alpha beta-hydrolase fold
WU22_RS16450	COG0513	Belongs to the DEAD box helicase family
WU22_RS16470	COG1058	Belongs to the CinA family
WU22_RS16470	COG1546	Belongs to the CinA family
WU22_RS16475	COG1414	Transcriptional regulator
WU22_RS16495	COG0167	dihydroorotate dehydrogenase activity
WU22_RS16500	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
WU22_RS16505	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
WU22_RS16515	COG0583	DNA-binding transcription factor activity
WU22_RS16575	COG0280	phosphate acetyltransferase
WU22_RS16575	COG0281	malic enzyme
WU22_RS16585	COG0601	transmembrane transport
WU22_RS16590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WU22_RS16595	COG4172	Belongs to the ABC transporter superfamily
WU22_RS16625	COG0640	Transcriptional regulator
WU22_RS16640	COG3135	benzoate transporter
WU22_RS16645	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WU22_RS16650	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WU22_RS16655	COG0742	ribosomal rna small subunit methyltransferase
WU22_RS16670	COG3639	organic phosphonate transmembrane transporter activity
WU22_RS16675	COG3639	organic phosphonate transmembrane transporter activity
WU22_RS16680	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
WU22_RS16715	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
WU22_RS16720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WU22_RS16730	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WU22_RS16735	COG1546	Belongs to the CinA family
WU22_RS16735	COG1058	Belongs to the CinA family
WU22_RS16740	COG0284	orotidine-5'-phosphate decarboxylase activity
WU22_RS16745	COG1252	NADH dehydrogenase
WU22_RS16760	COG3468	outer membrane autotransporter barrel domain protein
WU22_RS16765	COG0459	protein refolding
WU22_RS16770	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WU22_RS16790	COG1053	succinate dehydrogenase
WU22_RS16800	COG0583	DNA-binding transcription factor activity
WU22_RS16805	COG1053	succinate dehydrogenase
WU22_RS16825	COG3706	GGDEF domain
WU22_RS16860	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WU22_RS16865	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
WU22_RS16875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WU22_RS16885	COG0069	glutamate synthase activity
WU22_RS16890	COG2391	methyltransferase activity
WU22_RS16895	COG0679	Auxin Efflux Carrier
WU22_RS16920	COG0557	exoribonuclease II activity
WU22_RS16925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WU22_RS16935	COG3128	pkhd-type hydroxylase
WU22_RS16940	COG0776	regulation of translation
WU22_RS16970	COG0642	Histidine kinase
WU22_RS16975	COG3158	transport of potassium into the cell
WU22_RS16980	COG0137	argininosuccinate synthase activity
WU22_RS16985	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
WU22_RS16990	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WU22_RS17000	COG0583	DNA-binding transcription factor activity
WU22_RS17010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WU22_RS17030	COG2186	Transcriptional regulator
WU22_RS17040	COG2223	nitrite transmembrane transporter activity
WU22_RS17050	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WU22_RS17055	COG0450	alkyl hydroperoxide reductase
WU22_RS17075	COG1214	PFAM Peptidase M22, glycoprotease
WU22_RS17080	COG1573	uracil-dna glycosylase
WU22_RS17085	COG0477	Major facilitator Superfamily
WU22_RS17090	COG1196	nuclear chromosome segregation
WU22_RS17100	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WU22_RS17105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WU22_RS17120	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WU22_RS17125	COG1122	ATPase activity
WU22_RS17130	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
WU22_RS17135	COG1268	BioY protein
WU22_RS17155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WU22_RS17190	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WU22_RS17195	COG2878	Part of a membrane complex involved in electron transport
WU22_RS17210	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WU22_RS17215	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
WU22_RS17220	COG0251	oxidation-reduction process
WU22_RS17230	COG3228	Belongs to the MtfA family
WU22_RS17235	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WU22_RS17245	COG0133	tryptophan synthase activity
WU22_RS17250	COG0159	tryptophan synthase activity
WU22_RS17255	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
WU22_RS17260	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
WU22_RS17275	COG1530	ribonuclease E activity
WU22_RS17285	COG0546	phosphoglycolate phosphatase activity
WU22_RS17290	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
WU22_RS17295	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
WU22_RS17305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU22_RS17310	COG0583	DNA-binding transcription factor activity
WU22_RS17320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU22_RS17340	COG0251	oxidation-reduction process
WU22_RS17345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WU22_RS17345	COG1017	nitric oxide dioxygenase activity
WU22_RS17350	COG2031	fatty acid transporter
WU22_RS17355	COG1012	belongs to the aldehyde dehydrogenase family
WU22_RS17360	COG1802	Transcriptional regulator
WU22_RS17370	COG1278	Cold shock
WU22_RS17375	COG0583	DNA-binding transcription factor activity
WU22_RS17395	COG0183	Belongs to the thiolase family
WU22_RS17405	COG1960	acyl-CoA dehydrogenase activity
WU22_RS17410	COG0583	DNA-binding transcription factor activity
WU22_RS17415	COG3181	Tripartite tricarboxylate transporter family receptor
WU22_RS17420	COG1024	Enoyl-CoA hydratase
WU22_RS17425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU22_RS17430	COG1253	flavin adenine dinucleotide binding
WU22_RS17435	COG1285	pathogenesis
WU22_RS17445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WU22_RS17460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WU22_RS17470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WU22_RS17480	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU22_RS17485	COG3181	Tripartite tricarboxylate transporter family receptor
WU22_RS17490	COG1960	acyl-CoA dehydrogenase activity
WU22_RS17510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WU22_RS17515	COG1024	Enoyl-CoA hydratase
WU22_RS17520	COG1960	acyl-CoA dehydrogenase activity
WU22_RS17540	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WU22_RS17545	COG0022	dehydrogenase e1 component
WU22_RS17550	COG1024	Enoyl-CoA hydratase
WU22_RS17555	COG0508	dehydrogenase complex catalyzes the overall conversion of
WU22_RS17575	COG0683	leucine binding
WU22_RS17580	COG0559	Belongs to the binding-protein-dependent transport system permease family
WU22_RS17585	COG0411	ABC transporter
WU22_RS17595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WU22_RS17610	COG3181	Tripartite tricarboxylate transporter family receptor
WU22_RS17635	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WU22_RS17640	COG0793	Belongs to the peptidase S41A family
WU22_RS17645	COG4942	peptidase
WU22_RS17650	COG0588	phosphoglycerate mutase activity
WU22_RS17655	COG1054	Belongs to the UPF0176 family
WU22_RS17660	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
WU22_RS17665	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
WU22_RS17670	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WU22_RS17675	COG3181	Tripartite tricarboxylate transporter family receptor
WU22_RS17690	COG2226	methyltransferase
WU22_RS17695	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
WU22_RS17710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WU22_RS17715	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
WU22_RS17740	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
WU22_RS17765	COG1335	isochorismatase
WU22_RS17770	COG2309	aminopeptidase activity
WU22_RS17775	COG0596	Alpha beta hydrolase
WU22_RS17780	COG3473	Maleate cis-trans isomerase
WU22_RS17790	COG2068	MobA-Related Protein
WU22_RS17815	COG2204	response regulator
WU22_RS17820	COG5000	phosphorelay sensor kinase activity
WU22_RS17830	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WU22_RS17830	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WU22_RS17840	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
WU22_RS17870	COG0583	DNA-binding transcription factor activity
WU22_RS17885	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
WU22_RS17890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WU22_RS17895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WU22_RS17910	COG0758	DNA mediated transformation
WU22_RS17915	COG1522	sequence-specific DNA binding
WU22_RS17925	COG0242	peptide deformylase activity
WU22_RS17940	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WU22_RS17950	COG0546	phosphoglycolate phosphatase activity
WU22_RS17970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WU22_RS17975	COG1942	4-Oxalocrotonate Tautomerase
WU22_RS17980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WU22_RS18005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WU22_RS18025	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WU22_RS18030	COG1024	Enoyl-CoA hydratase
WU22_RS18035	COG1414	Transcriptional regulator
WU22_RS18040	COG0318	PFAM AMP-dependent synthetase and ligase
WU22_RS18045	COG3181	Tripartite tricarboxylate transporter family receptor
WU22_RS18075	COG0583	DNA-binding transcription factor activity
WU22_RS18090	COG3422	double-strand break repair
WU22_RS18095	COG0330	HflC and HflK could
WU22_RS18105	COG0251	oxidation-reduction process
WU22_RS18150	COG3723	Recombinational DNA repair protein, rece pathway
WU22_RS18185	COG0582	viral genome integration into host DNA
WU22_RS18210	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
WU22_RS18220	COG0706	membrane insertase activity
WU22_RS18225	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
WU22_RS18230	COG0594	ribonuclease P activity
WU22_RS18235	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WU22_RS18240	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WU22_RS18255	COG1414	Transcriptional regulator
WU22_RS18260	COG0154	amidase activity
WU22_RS18275	COG1304	FMN binding
WU22_RS18295	COG1960	acyl-CoA dehydrogenase activity
WU22_RS18315	COG1960	acyl-CoA dehydrogenase activity
WU22_RS18330	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WU22_RS18345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WU22_RS18350	COG3181	Tripartite tricarboxylate transporter family receptor
WU22_RS18360	COG2358	TRAP transporter, solute receptor (TAXI family
WU22_RS18370	COG1629	transport
WU22_RS18375	COG2922	Belongs to the Smg family
WU22_RS18400	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
WU22_RS18405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WU22_RS18410	COG1028	Short-chain dehydrogenase reductase Sdr
WU22_RS18415	COG1012	belongs to the aldehyde dehydrogenase family
WU22_RS18425	COG0028	Belongs to the TPP enzyme family
WU22_RS18430	COG1522	sequence-specific DNA binding
WU22_RS18435	COG3781	membrane
WU22_RS18445	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WU22_RS18465	COG4206	TonB-dependent receptor
WU22_RS18470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WU22_RS18475	COG2022	thiamine diphosphate biosynthetic process
WU22_RS18480	COG0351	phosphomethylpyrimidine kinase
WU22_RS18485	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
WU22_RS18500	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
WU22_RS18510	COG0628	permease
WU22_RS18520	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
WU22_RS18530	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WU22_RS18535	COG0049	tRNA binding
WU22_RS18540	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WU22_RS18545	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WU22_RS18550	COG0051	transcription antitermination factor activity, RNA binding
WU22_RS18555	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WU22_RS18560	COG0088	Forms part of the polypeptide exit tunnel
WU22_RS18565	COG0089	rRNA binding
WU22_RS18570	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WU22_RS18575	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WU22_RS18580	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WU22_RS18585	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WU22_RS18590	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WU22_RS18595	COG0255	Belongs to the universal ribosomal protein uL29 family
WU22_RS18600	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WU22_RS18620	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WU22_RS18625	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WU22_RS18630	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WU22_RS18635	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WU22_RS18640	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WU22_RS18645	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WU22_RS18650	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WU22_RS18655	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WU22_RS18660	COG1841	ribosomal large subunit assembly
WU22_RS18665	COG0200	Binds to the 23S rRNA
WU22_RS18670	COG0201	protein transport
WU22_RS18675	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WU22_RS18680	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WU22_RS18685	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WU22_RS18690	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WU22_RS18695	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WU22_RS18700	COG0202	RNA polymerase activity
WU22_RS18705	COG0203	ribosomal protein L17
WU22_RS18710	COG0537	adenosine 5'-monophosphoramidase activity
WU22_RS18715	COG1324	tolerance protein
WU22_RS18720	COG4232	protein-disulfide reductase activity
WU22_RS18735	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WU22_RS18745	COG1333	cytochrome c biogenesis protein
WU22_RS18750	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WU22_RS18765	COG1965	Belongs to the frataxin family
WU22_RS18775	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
WU22_RS18780	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
WU22_RS18785	COG0232	Belongs to the dGTPase family. Type 2 subfamily
WU22_RS18800	COG2814	Major facilitator Superfamily
WU22_RS18805	COG0629	single-stranded DNA binding
WU22_RS18845	COG0402	S-adenosylhomocysteine deaminase activity
WU22_RS18855	COG0438	transferase activity, transferring glycosyl groups
WU22_RS18875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WU22_RS18900	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
WU22_RS18905	COG2186	Transcriptional regulator
WU22_RS18925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WU22_RS18930	COG1956	GAF domain-containing protein
WU22_RS18935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WU22_RS18950	COG1652	LysM domain
WU22_RS18965	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WU22_RS18980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WU22_RS19010	COG3181	Tripartite tricarboxylate transporter family receptor
WU22_RS19025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WU22_RS19040	COG1024	Enoyl-CoA hydratase
WU22_RS19055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU22_RS19060	COG1309	transcriptional regulator
WU22_RS19065	COG2816	NAD+ diphosphatase activity
WU22_RS19070	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WU22_RS19155	COG2814	Major facilitator Superfamily
WU22_RS19160	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WU22_RS19180	COG1999	signal sequence binding
WU22_RS19185	COG0109	protoheme IX farnesyltransferase activity
WU22_RS19225	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WU22_RS19245	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
WU22_RS19250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WU22_RS19260	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
WU22_RS19265	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
WU22_RS19275	COG0067	glutamate synthase
WU22_RS19275	COG0069	glutamate synthase activity
WU22_RS19275	COG0070	glutamate synthase
WU22_RS19285	COG3047	cAMP biosynthetic process
WU22_RS19295	COG1127	ABC transporter
WU22_RS19300	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WU22_RS19305	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WU22_RS19310	COG2853	Lipoprotein
WU22_RS19320	COG1131	(ABC) transporter
WU22_RS19325	COG0842	Transport permease protein
WU22_RS19335	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WU22_RS19340	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
WU22_RS19345	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
WU22_RS19350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
WU22_RS19355	COG0131	Imidazoleglycerol-phosphate dehydratase
WU22_RS19360	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
WU22_RS19365	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
WU22_RS19370	COG0107	imidazoleglycerol-phosphate synthase activity
WU22_RS19375	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
WU22_RS19380	COG0140	phosphoribosyl-ATP diphosphatase activity
WU22_RS19385	COG0537	adenosine 5'-monophosphoramidase activity
WU22_RS19390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WU22_RS19395	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WU22_RS19410	COG3181	Tripartite tricarboxylate transporter family receptor
WU22_RS19445	COG3702	type iv secretory pathway
WU22_RS19450	COG3451	type IV secretory pathway VirB4
WU22_RS19465	COG3736	Type IV secretory pathway, component VirB8
WU22_RS19470	COG3504	Conjugal transfer protein
WU22_RS19475	COG2948	multi-organism process
WU22_RS19480	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
WU22_RS19490	COG0697	spore germination
WU22_RS19510	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WU22_RS19515	COG0747	negative chemotaxis
WU22_RS19520	COG0601	transmembrane transport
WU22_RS19525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WU22_RS19530	COG0444	Belongs to the ABC transporter superfamily
WU22_RS19540	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
WU22_RS19550	COG0494	nUDIX hydrolase
WU22_RS19585	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
WU22_RS19590	COG0237	dephospho-CoA kinase activity
WU22_RS19595	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
WU22_RS19610	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
WU22_RS19615	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
WU22_RS19625	COG0477	Major facilitator Superfamily
WU22_RS19630	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
WU22_RS19645	COG1126	abc transporter atp-binding protein
WU22_RS19650	COG0765	amino acid transport
WU22_RS19655	COG4597	amino acid ABC transporter
WU22_RS19660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WU22_RS19665	COG2884	Cell division ATP-binding protein ftsE
WU22_RS19670	COG2177	Part of the ABC transporter FtsEX involved in
WU22_RS19675	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
WU22_RS19685	COG1194	a g-specific adenine glycosylase
WU22_RS19695	COG2226	methyltransferase
WU22_RS19705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU22_RS19710	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU22_RS19725	COG1024	Enoyl-CoA hydratase
WU22_RS19745	COG1024	Enoyl-CoA hydratase
WU22_RS19750	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU22_RS19755	COG3181	Tripartite tricarboxylate transporter family receptor
WU22_RS19765	COG0753	catalase activity
WU22_RS19770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WU22_RS19775	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
WU22_RS19785	COG2175	clavaminate synthase activity
WU22_RS19790	COG1473	amidohydrolase
WU22_RS19800	COG4608	Belongs to the ABC transporter superfamily
WU22_RS19805	COG0444	Belongs to the ABC transporter superfamily
WU22_RS19820	COG0747	negative chemotaxis
WU22_RS19825	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WU22_RS19860	COG0436	Aminotransferase
WU22_RS19865	COG1278	Cold shock