locus-tag	class	description
ABC12_RS00005	COG0445	tRNA wobble uridine modification
ABC12_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
ABC12_RS00015	COG1192	Involved in chromosome partitioning
ABC12_RS00025	COG1475	DNA binding
ABC12_RS00030	COG0252	asparaginase activity
ABC12_RS00055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ABC12_RS00065	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ABC12_RS00075	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ABC12_RS00080	COG0081	regulation of translation
ABC12_RS00085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ABC12_RS00090	COG0222	ribosome binding
ABC12_RS00095	COG0085	RNA polymerase activity
ABC12_RS00100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ABC12_RS00140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ABC12_RS00165	COG1024	Enoyl-CoA hydratase
ABC12_RS00185	COG0752	glycyl-tRNA synthetase alpha subunit
ABC12_RS00190	COG0751	glycine-tRNA ligase activity
ABC12_RS00195	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ABC12_RS00200	COG0204	Acyl-transferase
ABC12_RS00215	COG0242	peptide deformylase activity
ABC12_RS00250	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
ABC12_RS00255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ABC12_RS00260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ABC12_RS00260	COG2813	Specifically methylates the guanine in position
ABC12_RS00275	COG2223	nitrite transmembrane transporter activity
ABC12_RS00285	COG1794	racemase activity, acting on amino acids and derivatives
ABC12_RS00290	COG1126	abc transporter atp-binding protein
ABC12_RS00295	COG0765	amino acid transport
ABC12_RS00300	COG0765	amino acid transport
ABC12_RS00305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ABC12_RS00370	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ABC12_RS00400	COG0326	Molecular chaperone. Has ATPase activity
ABC12_RS00405	COG0625	glutathione transferase activity
ABC12_RS00420	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ABC12_RS00425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ABC12_RS00455	COG0438	transferase activity, transferring glycosyl groups
ABC12_RS00460	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ABC12_RS00465	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ABC12_RS00495	COG0859	PFAM glycosyl transferase family 9
ABC12_RS00510	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ABC12_RS00520	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ABC12_RS00525	COG1127	ABC transporter
ABC12_RS00545	COG1686	Belongs to the peptidase S11 family
ABC12_RS00555	COG2921	Belongs to the UPF0250 family
ABC12_RS00560	COG0321	lipoyl(octanoyl) transferase activity
ABC12_RS00565	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ABC12_RS00600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ABC12_RS00610	COG0018	arginyl-trna synthetase
ABC12_RS00630	COG0395	ABC-type sugar transport system, permease component
ABC12_RS00635	COG1175	transmembrane transport
ABC12_RS00640	COG1653	transport
ABC12_RS00645	COG3842	ATPase activity
ABC12_RS00650	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ABC12_RS00660	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ABC12_RS00680	COG1609	Transcriptional regulator
ABC12_RS00690	COG0154	amidase activity
ABC12_RS00695	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ABC12_RS00705	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ABC12_RS00715	COG0583	DNA-binding transcription factor activity
ABC12_RS00730	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ABC12_RS00735	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ABC12_RS00750	COG1802	Transcriptional regulator
ABC12_RS00765	COG1024	Enoyl-CoA hydratase
ABC12_RS00775	COG3181	Tripartite tricarboxylate transporter family receptor
ABC12_RS00790	COG1984	allophanate hydrolase subunit 2
ABC12_RS00795	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ABC12_RS00805	COG0583	DNA-binding transcription factor activity
ABC12_RS00810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ABC12_RS00820	COG5002	protein histidine kinase activity
ABC12_RS00830	COG5002	protein histidine kinase activity
ABC12_RS00835	COG0745	RESPONSE REGULATOR receiver
ABC12_RS00840	COG2226	methyltransferase
ABC12_RS00855	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ABC12_RS00875	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ABC12_RS00885	COG0513	Belongs to the DEAD box helicase family
ABC12_RS00890	COG1280	lysine exporter protein (LysE YggA)
ABC12_RS00895	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ABC12_RS00930	COG1054	Belongs to the UPF0176 family
ABC12_RS00935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ABC12_RS00935	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ABC12_RS00945	COG0489	protein tyrosine kinase activity
ABC12_RS00960	COG0717	Belongs to the dCTP deaminase family
ABC12_RS00990	COG2081	HI0933 family
ABC12_RS01000	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ABC12_RS01010	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ABC12_RS01015	COG0509	glycine decarboxylation via glycine cleavage system
ABC12_RS01020	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ABC12_RS01020	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ABC12_RS01060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ABC12_RS01075	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ABC12_RS01085	COG1414	Transcriptional regulator
ABC12_RS01090	COG1028	Short-chain dehydrogenase reductase Sdr
ABC12_RS01095	COG2031	fatty acid transporter
ABC12_RS01100	COG1250	3-hydroxyacyl-CoA dehydrogenase
ABC12_RS01110	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ABC12_RS01115	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ABC12_RS01125	COG4257	antibiotic catabolic process
ABC12_RS01150	COG1012	belongs to the aldehyde dehydrogenase family
ABC12_RS01155	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ABC12_RS01160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ABC12_RS01185	COG1028	Short-chain dehydrogenase reductase Sdr
ABC12_RS01195	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ABC12_RS01210	COG2188	Transcriptional regulator
ABC12_RS01215	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ABC12_RS01240	COG0617	tRNA 3'-terminal CCA addition
ABC12_RS01255	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ABC12_RS01260	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ABC12_RS01265	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ABC12_RS01270	COG0586	Pfam SNARE associated Golgi protein
ABC12_RS01275	COG0860	N-Acetylmuramoyl-L-alanine amidase
ABC12_RS01280	COG0802	atpase or kinase
ABC12_RS01285	COG0114	fumarate hydratase activity
ABC12_RS01295	COG3181	Tripartite tricarboxylate transporter family receptor
ABC12_RS01305	COG0405	Gamma-glutamyltransferase
ABC12_RS01310	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ABC12_RS01320	COG1960	acyl-CoA dehydrogenase activity
ABC12_RS01345	COG1294	oxidase, subunit
ABC12_RS01355	COG4988	ABC transporter
ABC12_RS01360	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ABC12_RS01365	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ABC12_RS01380	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ABC12_RS01410	COG2969	positive regulation of protein catabolic process
ABC12_RS01415	COG0625	glutathione transferase activity
ABC12_RS01420	COG2857	Cytochrome c1
ABC12_RS01425	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ABC12_RS01430	COG0723	plastoquinol--plastocyanin reductase activity
ABC12_RS01435	COG1970	mechanosensitive ion channel activity
ABC12_RS01440	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ABC12_RS01455	COG2808	Putative FMN-binding domain
ABC12_RS01460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ABC12_RS01465	COG0747	negative chemotaxis
ABC12_RS01470	COG0657	acetylesterase activity
ABC12_RS01480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ABC12_RS01485	COG2207	Transcriptional regulator
ABC12_RS01490	COG0129	dihydroxy-acid dehydratase activity
ABC12_RS01495	COG2814	Major facilitator Superfamily
ABC12_RS01500	COG0583	DNA-binding transcription factor activity
ABC12_RS01510	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
ABC12_RS01580	COG1024	Enoyl-CoA hydratase
ABC12_RS01585	COG1960	acyl-CoA dehydrogenase activity
ABC12_RS01610	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ABC12_RS01615	COG0352	thiamine-phosphate diphosphorylase activity
ABC12_RS01630	COG1678	Uncharacterized ACR, COG1678
ABC12_RS01635	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ABC12_RS01640	COG0540	Belongs to the ATCase OTCase family
ABC12_RS01655	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ABC12_RS01665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ABC12_RS01700	COG1234	tRNA 3'-trailer cleavage
ABC12_RS01720	COG3064	Membrane
ABC12_RS01750	COG1683	Conserved Protein
ABC12_RS01755	COG1120	ATPase activity
ABC12_RS01760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ABC12_RS01765	COG4558	Periplasmic binding protein
ABC12_RS01770	COG3720	iron ion transport
ABC12_RS01780	COG3712	iron ion homeostasis
ABC12_RS01785	COG1595	DNA-templated transcription, initiation
ABC12_RS01820	COG1802	Transcriptional regulator
ABC12_RS01830	COG3069	C4-dicarboxylate transmembrane transporter activity
ABC12_RS01840	COG1012	belongs to the aldehyde dehydrogenase family
ABC12_RS01875	COG2860	membrane
ABC12_RS01880	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ABC12_RS01885	COG0708	Exodeoxyribonuclease III
ABC12_RS01890	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ABC12_RS01895	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ABC12_RS01900	COG0154	amidase activity
ABC12_RS01905	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ABC12_RS01910	COG1077	Cell shape determining protein MreB Mrl
ABC12_RS01915	COG1792	Involved in formation and maintenance of cell shape
ABC12_RS01925	COG0768	penicillin binding
ABC12_RS01930	COG0772	Belongs to the SEDS family
ABC12_RS01935	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
ABC12_RS01940	COG0471	metal ion transport
ABC12_RS01945	COG1309	transcriptional regulator
ABC12_RS01955	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ABC12_RS01970	COG2823	Periplasmic or secreted lipoprotein
ABC12_RS01975	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ABC12_RS01990	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ABC12_RS02010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ABC12_RS02020	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ABC12_RS02040	COG0492	ferredoxin-NADP+ reductase activity
ABC12_RS02050	COG3181	Tripartite tricarboxylate transporter family receptor
ABC12_RS02055	COG1024	Enoyl-CoA hydratase
ABC12_RS02055	COG1250	3-hydroxyacyl-CoA dehydrogenase
ABC12_RS02060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ABC12_RS02065	COG0028	Belongs to the TPP enzyme family
ABC12_RS02090	COG3181	Tripartite tricarboxylate transporter family receptor
ABC12_RS02100	COG0697	spore germination
ABC12_RS02130	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ABC12_RS02135	COG0463	Glycosyl transferase, family 2
ABC12_RS02155	COG0786	glutamate:sodium symporter activity
ABC12_RS02165	COG2031	fatty acid transporter
ABC12_RS02180	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ABC12_RS02185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ABC12_RS02195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ABC12_RS02210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ABC12_RS02220	COG1285	pathogenesis
ABC12_RS02225	COG1253	flavin adenine dinucleotide binding
ABC12_RS02230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ABC12_RS02235	COG1024	Enoyl-CoA hydratase
ABC12_RS02240	COG3181	Tripartite tricarboxylate transporter family receptor
ABC12_RS02245	COG0583	DNA-binding transcription factor activity
ABC12_RS02250	COG1960	acyl-CoA dehydrogenase activity
ABC12_RS02260	COG0183	Belongs to the thiolase family
ABC12_RS02280	COG0583	DNA-binding transcription factor activity
ABC12_RS02285	COG1278	Cold shock
ABC12_RS02295	COG1802	Transcriptional regulator
ABC12_RS02300	COG1012	belongs to the aldehyde dehydrogenase family
ABC12_RS02305	COG2031	fatty acid transporter
ABC12_RS02310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ABC12_RS02310	COG1017	nitric oxide dioxygenase activity
ABC12_RS02315	COG0251	oxidation-reduction process
ABC12_RS02335	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ABC12_RS02345	COG0583	DNA-binding transcription factor activity
ABC12_RS02350	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ABC12_RS02360	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ABC12_RS02365	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ABC12_RS02370	COG0546	phosphoglycolate phosphatase activity
ABC12_RS02380	COG1530	ribonuclease E activity
ABC12_RS02395	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ABC12_RS02400	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ABC12_RS02405	COG0159	tryptophan synthase activity
ABC12_RS02410	COG0133	tryptophan synthase activity
ABC12_RS02420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ABC12_RS02425	COG3228	Belongs to the MtfA family
ABC12_RS02435	COG0251	oxidation-reduction process
ABC12_RS02440	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ABC12_RS02445	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ABC12_RS02460	COG2878	Part of a membrane complex involved in electron transport
ABC12_RS02465	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ABC12_RS02500	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ABC12_RS02520	COG1268	BioY protein
ABC12_RS02525	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ABC12_RS02530	COG1122	ATPase activity
ABC12_RS02535	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ABC12_RS02550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ABC12_RS02555	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ABC12_RS02565	COG1196	nuclear chromosome segregation
ABC12_RS02570	COG0477	Major facilitator Superfamily
ABC12_RS02575	COG1573	uracil-dna glycosylase
ABC12_RS02580	COG1214	PFAM Peptidase M22, glycoprotease
ABC12_RS02605	COG0450	alkyl hydroperoxide reductase
ABC12_RS02610	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ABC12_RS02620	COG2223	nitrite transmembrane transporter activity
ABC12_RS02630	COG2186	Transcriptional regulator
ABC12_RS02650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ABC12_RS02660	COG0583	DNA-binding transcription factor activity
ABC12_RS02670	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ABC12_RS02675	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ABC12_RS02680	COG0137	argininosuccinate synthase activity
ABC12_RS02685	COG3158	transport of potassium into the cell
ABC12_RS02690	COG0642	Histidine kinase
ABC12_RS02720	COG0776	regulation of translation
ABC12_RS02725	COG3128	pkhd-type hydroxylase
ABC12_RS02735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ABC12_RS02740	COG0557	exoribonuclease II activity
ABC12_RS02765	COG0679	Auxin Efflux Carrier
ABC12_RS02770	COG2391	methyltransferase activity
ABC12_RS02775	COG0069	glutamate synthase activity
ABC12_RS02785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ABC12_RS02795	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
ABC12_RS02800	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ABC12_RS02835	COG3706	GGDEF domain
ABC12_RS02850	COG1053	succinate dehydrogenase
ABC12_RS02855	COG0583	DNA-binding transcription factor activity
ABC12_RS02865	COG1053	succinate dehydrogenase
ABC12_RS02885	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ABC12_RS02890	COG0459	protein refolding
ABC12_RS02895	COG3468	outer membrane autotransporter barrel domain protein
ABC12_RS02910	COG1252	NADH dehydrogenase
ABC12_RS02915	COG0284	orotidine-5'-phosphate decarboxylase activity
ABC12_RS02920	COG1546	Belongs to the CinA family
ABC12_RS02920	COG1058	Belongs to the CinA family
ABC12_RS02925	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ABC12_RS02935	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ABC12_RS02940	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ABC12_RS02975	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ABC12_RS02980	COG3639	organic phosphonate transmembrane transporter activity
ABC12_RS02985	COG3639	organic phosphonate transmembrane transporter activity
ABC12_RS03005	COG0742	ribosomal rna small subunit methyltransferase
ABC12_RS03010	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ABC12_RS03015	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ABC12_RS03020	COG3135	benzoate transporter
ABC12_RS03035	COG0640	Transcriptional regulator
ABC12_RS03065	COG4172	Belongs to the ABC transporter superfamily
ABC12_RS03070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ABC12_RS03075	COG0601	transmembrane transport
ABC12_RS03085	COG0280	phosphate acetyltransferase
ABC12_RS03085	COG0281	malic enzyme
ABC12_RS03145	COG0583	DNA-binding transcription factor activity
ABC12_RS03155	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ABC12_RS03160	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ABC12_RS03165	COG0167	dihydroorotate dehydrogenase activity
ABC12_RS03185	COG1414	Transcriptional regulator
ABC12_RS03190	COG1546	Belongs to the CinA family
ABC12_RS03190	COG1058	Belongs to the CinA family
ABC12_RS03210	COG0513	Belongs to the DEAD box helicase family
ABC12_RS03240	COG0429	hydrolase of the alpha beta-hydrolase fold
ABC12_RS03245	COG4783	chaperone-mediated protein folding
ABC12_RS03260	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ABC12_RS03285	COG0006	proline dipeptidase activity
ABC12_RS03295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ABC12_RS03315	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ABC12_RS03320	COG0632	four-way junction helicase activity
ABC12_RS03335	COG2255	four-way junction helicase activity
ABC12_RS03340	COG0514	ATP-dependent DNA helicase (RecQ)
ABC12_RS03355	COG0288	reversible hydration of carbon dioxide
ABC12_RS03360	COG0154	amidase activity
ABC12_RS03370	COG4211	Belongs to the binding-protein-dependent transport system permease family
ABC12_RS03400	COG1464	Belongs to the NlpA lipoprotein family
ABC12_RS03545	COG1196	nuclear chromosome segregation
ABC12_RS03615	COG2135	peptidase activity
ABC12_RS03630	COG0494	nUDIX hydrolase
ABC12_RS03635	COG0442	prolyl-tRNA aminoacylation
ABC12_RS03640	COG0824	Thioesterase
ABC12_RS03645	COG0811	peptide transport
ABC12_RS03650	COG0848	biopolymer transport protein
ABC12_RS03660	COG0823	Involved in the tonB-independent uptake of proteins
ABC12_RS03675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ABC12_RS03680	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ABC12_RS03715	COG0700	Nucleoside recognition
ABC12_RS03720	COG0469	pyruvate kinase activity
ABC12_RS03725	COG1929	Belongs to the glycerate kinase type-1 family
ABC12_RS03730	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ABC12_RS03735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ABC12_RS03740	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ABC12_RS03750	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ABC12_RS03760	COG2154	pterin-4-alpha-carbinolamine dehydratase
ABC12_RS03785	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ABC12_RS03790	COG0154	amidase activity
ABC12_RS03800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ABC12_RS03805	COG0601	transmembrane transport
ABC12_RS03810	COG0747	negative chemotaxis
ABC12_RS03830	COG0019	diaminopimelate decarboxylase activity
ABC12_RS03845	COG2353	YceI-like domain
ABC12_RS03850	COG4774	siderophore transport
ABC12_RS03855	COG3712	iron ion homeostasis
ABC12_RS03895	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ABC12_RS03900	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ABC12_RS03905	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ABC12_RS03910	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ABC12_RS03920	COG0142	geranyltranstransferase activity
ABC12_RS03930	COG0583	DNA-binding transcription factor activity
ABC12_RS03940	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
ABC12_RS03945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ABC12_RS03960	COG2994	toxin metabolic process
ABC12_RS03970	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
ABC12_RS03975	COG2274	protein secretion by the type I secretion system
ABC12_RS03980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ABC12_RS03985	COG1538	Outer membrane efflux protein
ABC12_RS04000	COG0765	amino acid transport
ABC12_RS04005	COG0765	amino acid transport
ABC12_RS04010	COG1126	abc transporter atp-binding protein
ABC12_RS04030	COG1028	Short-chain dehydrogenase reductase Sdr
ABC12_RS04040	COG1802	Transcriptional regulator
ABC12_RS04050	COG1802	Transcriptional regulator
ABC12_RS04060	COG0318	PFAM AMP-dependent synthetase and ligase
ABC12_RS04070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ABC12_RS04090	COG0028	Belongs to the TPP enzyme family
ABC12_RS04110	COG0308	aminopeptidase N
ABC12_RS04115	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ABC12_RS04125	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ABC12_RS04130	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ABC12_RS04135	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ABC12_RS04140	COG0560	Phosphoserine phosphatase
ABC12_RS04145	COG0583	DNA-binding transcription factor activity
ABC12_RS04150	COG3181	Tripartite tricarboxylate transporter family receptor
ABC12_RS04155	COG0028	Belongs to the TPP enzyme family
ABC12_RS04170	COG4774	siderophore transport
ABC12_RS04175	COG4774	siderophore transport
ABC12_RS04185	COG1007	ATP synthesis coupled electron transport
ABC12_RS04200	COG0713	ATP synthesis coupled electron transport
ABC12_RS04210	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ABC12_RS04215	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ABC12_RS04220	COG1034	ATP synthesis coupled electron transport
ABC12_RS04230	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ABC12_RS04235	COG0649	NAD binding
ABC12_RS04240	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ABC12_RS04245	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ABC12_RS04250	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ABC12_RS04255	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ABC12_RS04285	COG0671	phosphoesterase, PA-phosphatase related
ABC12_RS04295	COG1597	lipid kinase activity
ABC12_RS04300	COG0583	DNA-binding transcription factor activity
ABC12_RS04305	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ABC12_RS04315	COG1733	regulation of RNA biosynthetic process
ABC12_RS04320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ABC12_RS04325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ABC12_RS04340	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
ABC12_RS04360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ABC12_RS04380	COG3608	succinylglutamate desuccinylase aspartoacylase
ABC12_RS04385	COG0626	cystathionine gamma-synthase activity
ABC12_RS04390	COG0583	DNA-binding transcription factor activity
ABC12_RS04425	COG3799	methylaspartate ammonia-lyase activity
ABC12_RS04435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ABC12_RS04445	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ABC12_RS04450	COG0149	triose-phosphate isomerase activity
ABC12_RS04470	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ABC12_RS04485	COG1185	polyribonucleotide nucleotidyltransferase activity
ABC12_RS04490	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ABC12_RS04505	COG1183	phosphatidylcholine synthase activity
ABC12_RS04510	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ABC12_RS04515	COG0440	acetolactate synthase activity
ABC12_RS04520	COG0028	Belongs to the TPP enzyme family
ABC12_RS04535	COG5265	(ABC) transporter
ABC12_RS04540	COG0500	methyltransferase
ABC12_RS04560	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
ABC12_RS04580	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ABC12_RS04590	COG0511	ligase activity, forming carbon-carbon bonds
ABC12_RS04615	COG2188	Transcriptional regulator
ABC12_RS04620	COG0439	Biotin carboxylase
ABC12_RS04625	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ABC12_RS04670	COG5265	(ABC) transporter
ABC12_RS04680	COG0667	Aldo Keto reductase
ABC12_RS04695	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ABC12_RS04735	COG0583	DNA-binding transcription factor activity
ABC12_RS04760	COG2814	Major facilitator Superfamily
ABC12_RS04770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ABC12_RS04785	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ABC12_RS04795	COG0287	Prephenate dehydrogenase
ABC12_RS04800	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ABC12_RS04805	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ABC12_RS04825	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ABC12_RS04830	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ABC12_RS04835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ABC12_RS04840	COG1596	polysaccharide export
ABC12_RS04840	COG1555	photosystem II stabilization
ABC12_RS04855	COG2951	lytic endotransglycosylase activity
ABC12_RS04860	COG0123	including yeast histone deacetylase and acetoin utilization protein
ABC12_RS04875	COG1960	acyl-CoA dehydrogenase activity
ABC12_RS04880	COG0450	alkyl hydroperoxide reductase
ABC12_RS04895	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ABC12_RS04900	COG4208	sulfate ABC transporter
ABC12_RS04905	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ABC12_RS04935	COG0335	large ribosomal subunit rRNA binding
ABC12_RS04950	COG0667	Aldo Keto reductase
ABC12_RS04960	COG2814	Major facilitator Superfamily
ABC12_RS04965	COG3161	chorismate lyase activity
ABC12_RS04970	COG1187	pseudouridine synthase activity
ABC12_RS04980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ABC12_RS05000	COG1999	signal sequence binding
ABC12_RS05005	COG0339	signal peptide processing
ABC12_RS05010	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ABC12_RS05015	COG4566	intracellular signal transduction
ABC12_RS05025	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ABC12_RS05030	COG0508	dehydrogenase complex catalyzes the overall conversion of
ABC12_RS05035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ABC12_RS05040	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ABC12_RS05050	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ABC12_RS05055	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ABC12_RS05060	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ABC12_RS05065	COG0126	phosphoglycerate kinase activity
ABC12_RS05070	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ABC12_RS05075	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ABC12_RS05090	COG0625	glutathione transferase activity
ABC12_RS05125	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ABC12_RS05135	COG0521	Mo-molybdopterin cofactor biosynthetic process
ABC12_RS05145	COG0739	heme binding
ABC12_RS05155	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ABC12_RS05190	COG0745	RESPONSE REGULATOR receiver
ABC12_RS05205	COG0840	transmembrane signaling receptor activity
ABC12_RS05215	COG2201	protein-glutamate methylesterase activity
ABC12_RS05220	COG0745	RESPONSE REGULATOR receiver
ABC12_RS05225	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ABC12_RS05250	COG0667	Aldo Keto reductase
ABC12_RS05260	COG4535	Mg2 and Co2 transporter CorC
ABC12_RS05265	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ABC12_RS05270	COG1702	phosphate starvation-inducible protein PhoH
ABC12_RS05275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ABC12_RS05290	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ABC12_RS05295	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ABC12_RS05300	COG1862	Preprotein translocase
ABC12_RS05305	COG0343	queuine tRNA-ribosyltransferase activity
ABC12_RS05310	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ABC12_RS05315	COG2027	D-alanyl-D-alanine carboxypeptidase
ABC12_RS05320	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ABC12_RS05330	COG3468	outer membrane autotransporter barrel domain protein
ABC12_RS05345	COG3468	outer membrane autotransporter barrel domain protein
ABC12_RS05350	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ABC12_RS05350	COG1648	precorrin-2 dehydrogenase activity
ABC12_RS05375	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ABC12_RS05380	COG0741	lytic transglycosylase activity
ABC12_RS05385	COG0436	Aminotransferase
ABC12_RS05395	COG0281	malic enzyme
ABC12_RS05395	COG0280	phosphate acetyltransferase
ABC12_RS05405	COG2732	(Barnase) inhibitor
ABC12_RS05420	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ABC12_RS05445	COG0248	Ppx GppA phosphatase
ABC12_RS05455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ABC12_RS05465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ABC12_RS05470	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ABC12_RS05475	COG1534	Rna-binding protein
ABC12_RS05505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ABC12_RS05520	COG1295	ribonuclease BN
ABC12_RS05530	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ABC12_RS05535	COG0745	RESPONSE REGULATOR receiver
ABC12_RS05540	COG2205	protein histidine kinase activity
ABC12_RS05575	COG1022	Amp-dependent synthetase and ligase
ABC12_RS05590	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ABC12_RS05595	COG1028	Short-chain dehydrogenase reductase Sdr
ABC12_RS05605	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ABC12_RS05620	COG1136	(ABC) transporter
ABC12_RS05625	COG0084	hydrolase, TatD family'
ABC12_RS05655	COG2333	competence protein COMEC
ABC12_RS05655	COG0658	competence protein
ABC12_RS05665	COG0613	PHP domain protein
ABC12_RS05680	COG3539	Fimbrial protein
ABC12_RS05685	COG0280	phosphate acetyltransferase
ABC12_RS05685	COG0281	malic enzyme
ABC12_RS05695	COG1522	sequence-specific DNA binding
ABC12_RS05705	COG0567	Dehydrogenase, E1 component
ABC12_RS05710	COG0508	dehydrogenase complex catalyzes the overall conversion of
ABC12_RS05715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ABC12_RS05720	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ABC12_RS05725	COG1028	Short-chain dehydrogenase reductase Sdr
ABC12_RS05730	COG0583	DNA-binding transcription factor activity
ABC12_RS05740	COG3181	Tripartite tricarboxylate transporter family receptor
ABC12_RS05765	COG0180	Tryptophanyl-tRNA synthetase
ABC12_RS05770	COG2183	response to ionizing radiation
ABC12_RS05775	COG1199	ATP-dependent helicase activity
ABC12_RS05785	COG0564	pseudouridine synthase activity
ABC12_RS05795	COG3243	poly(R)-hydroxyalkanoic acid synthase
ABC12_RS05800	COG1028	Short-chain dehydrogenase reductase Sdr
ABC12_RS05805	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
ABC12_RS05820	COG0672	)-iron permease
ABC12_RS05860	COG0583	DNA-binding transcription factor activity
ABC12_RS05870	COG2814	Major facilitator Superfamily
ABC12_RS05885	COG1619	proteins homologs of microcin C7 resistance protein MccF
ABC12_RS05900	COG2084	Dehydrogenase
ABC12_RS05905	COG3181	Tripartite tricarboxylate transporter family receptor
ABC12_RS05930	COG2988	succinylglutamate desuccinylase activity
ABC12_RS05955	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ABC12_RS05960	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ABC12_RS05960	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ABC12_RS05965	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ABC12_RS05970	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ABC12_RS05970	COG0047	phosphoribosylformylglycinamidine synthase activity
ABC12_RS05975	COG3210	domain, Protein
ABC12_RS05975	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
ABC12_RS05975	COG3064	Membrane
ABC12_RS06000	COG0235	Class ii aldolase
ABC12_RS06005	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ABC12_RS06010	COG0720	synthase
ABC12_RS06015	COG0602	queuosine metabolic process
ABC12_RS06040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ABC12_RS06075	COG3181	Tripartite tricarboxylate transporter family receptor
ABC12_RS06105	COG3842	ATPase activity
ABC12_RS06115	COG0395	ABC-type sugar transport system, permease component
ABC12_RS06145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ABC12_RS06150	COG0420	3'-5' exonuclease activity
ABC12_RS06195	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ABC12_RS06195	COG0519	Catalyzes the synthesis of GMP from XMP
ABC12_RS06210	COG3550	peptidyl-serine autophosphorylation
ABC12_RS06220	COG0477	Major facilitator Superfamily
ABC12_RS06235	COG1228	amidohydrolase
ABC12_RS06245	COG1116	anion transmembrane transporter activity
ABC12_RS06250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ABC12_RS06290	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ABC12_RS06310	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ABC12_RS06340	COG2814	Major facilitator Superfamily
ABC12_RS06355	COG1280	lysine exporter protein (LysE YggA)
ABC12_RS06370	COG0747	negative chemotaxis
ABC12_RS06375	COG0601	transmembrane transport
ABC12_RS06380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ABC12_RS06385	COG4172	Belongs to the ABC transporter superfamily
ABC12_RS06390	COG1609	Transcriptional regulator
ABC12_RS06420	COG0586	Pfam SNARE associated Golgi protein
ABC12_RS06435	COG0500	methyltransferase
ABC12_RS06450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ABC12_RS06460	COG0756	dUTP diphosphatase activity
ABC12_RS06475	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ABC12_RS06480	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ABC12_RS06485	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ABC12_RS06490	COG0072	phenylalanine-tRNA ligase activity
ABC12_RS06490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ABC12_RS06495	COG0776	regulation of translation
ABC12_RS06565	COG0540	Belongs to the ATCase OTCase family
ABC12_RS06570	COG2974	May be involved in recombination
ABC12_RS06580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ABC12_RS06585	COG0583	DNA-binding transcription factor activity
ABC12_RS06605	COG1028	Short-chain dehydrogenase reductase Sdr
ABC12_RS06620	COG3842	ATPase activity
ABC12_RS06625	COG1250	3-hydroxyacyl-CoA dehydrogenase
ABC12_RS06625	COG1024	Enoyl-CoA hydratase
ABC12_RS06645	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ABC12_RS06650	COG2137	regulation of response to DNA damage stimulus
ABC12_RS06660	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ABC12_RS06670	COG0045	succinate-CoA ligase (ADP-forming) activity
ABC12_RS06675	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ABC12_RS06680	COG0861	Integral membrane protein TerC family
ABC12_RS06685	COG0861	Integral membrane protein TerC family
ABC12_RS06690	COG0181	hydroxymethylbilane synthase activity
ABC12_RS06750	COG4964	Belongs to the GSP D family
ABC12_RS06780	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ABC12_RS06790	COG0583	DNA-binding transcription factor activity
ABC12_RS06800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ABC12_RS06805	COG4311	Sarcosine oxidase, delta subunit
ABC12_RS06810	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ABC12_RS06810	COG0446	pyridine nucleotide-disulphide oxidoreductase
ABC12_RS06845	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ABC12_RS06850	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ABC12_RS06855	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ABC12_RS06860	COG0735	belongs to the Fur family
ABC12_RS06865	COG0497	DNA recombination
ABC12_RS06870	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ABC12_RS06875	COG1420	regulation of RNA biosynthetic process
ABC12_RS06880	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ABC12_RS06890	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ABC12_RS06900	COG0443	Heat shock 70 kDa protein
ABC12_RS06910	COG0612	Peptidase, M16
ABC12_RS06930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ABC12_RS06975	COG0745	RESPONSE REGULATOR receiver
ABC12_RS06985	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ABC12_RS06990	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ABC12_RS06995	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ABC12_RS07010	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ABC12_RS07030	COG1193	negative regulation of DNA recombination
ABC12_RS07035	COG0492	ferredoxin-NADP+ reductase activity
ABC12_RS07040	COG1674	ftsk spoiiie
ABC12_RS07045	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ABC12_RS07050	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ABC12_RS07055	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ABC12_RS07080	COG3706	GGDEF domain
ABC12_RS07100	COG2814	Major facilitator Superfamily
ABC12_RS07130	COG3486	L-lysine 6-monooxygenase (NADPH) activity
ABC12_RS07145	COG1028	Short-chain dehydrogenase reductase Sdr
ABC12_RS07155	COG3022	response to hydroperoxide
ABC12_RS07165	COG1289	transmembrane transporter activity
ABC12_RS07185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ABC12_RS07195	COG2197	response regulator
ABC12_RS07200	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ABC12_RS07205	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ABC12_RS07210	COG0189	ligase activity
ABC12_RS07220	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ABC12_RS07225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ABC12_RS07235	COG1764	response to oxidative stress
ABC12_RS07240	COG2423	ornithine cyclodeaminase activity
ABC12_RS07250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ABC12_RS07255	COG0765	amino acid transport
ABC12_RS07260	COG0765	amino acid transport
ABC12_RS07265	COG1126	abc transporter atp-binding protein
ABC12_RS07320	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ABC12_RS07330	COG2944	sequence-specific DNA binding
ABC12_RS07340	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ABC12_RS07345	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ABC12_RS07350	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ABC12_RS07355	COG0009	L-threonylcarbamoyladenylate synthase
ABC12_RS07360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ABC12_RS07365	COG1414	Transcriptional regulator
ABC12_RS07380	COG0765	amino acid transport
ABC12_RS07385	COG1126	abc transporter atp-binding protein
ABC12_RS07390	COG0028	Belongs to the TPP enzyme family
ABC12_RS07405	COG0028	Belongs to the TPP enzyme family
ABC12_RS07410	COG0583	DNA-binding transcription factor activity
ABC12_RS07415	COG4974	Belongs to the 'phage' integrase family
ABC12_RS07420	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ABC12_RS07425	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ABC12_RS07440	COG1686	Belongs to the peptidase S11 family
ABC12_RS07450	COG2814	Major facilitator Superfamily
ABC12_RS07460	COG1074	ATP-dependent DNA helicase activity
ABC12_RS07475	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ABC12_RS07480	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ABC12_RS07485	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ABC12_RS07505	COG2321	neutral zinc metallopeptidase
ABC12_RS07510	COG0009	L-threonylcarbamoyladenylate synthase
ABC12_RS07555	COG3360	Dodecin
ABC12_RS07560	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ABC12_RS07565	COG2850	peptidyl-arginine hydroxylation
ABC12_RS07570	COG3539	Fimbrial protein
ABC12_RS07575	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ABC12_RS07580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ABC12_RS07600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ABC12_RS07605	COG0765	amino acid transport
ABC12_RS07610	COG1126	abc transporter atp-binding protein
ABC12_RS07615	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ABC12_RS07620	COG1758	RNA polymerase activity
ABC12_RS07625	COG0194	GDP metabolic process
ABC12_RS07630	COG3258	Cytochrome c
ABC12_RS07635	COG2863	cytochrome
ABC12_RS07640	COG1028	Short-chain dehydrogenase reductase Sdr
ABC12_RS07645	COG0791	NLP P60 protein
ABC12_RS07650	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ABC12_RS07670	COG1561	YicC-like family, N-terminal region
ABC12_RS07675	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ABC12_RS07690	COG0840	transmembrane signaling receptor activity
ABC12_RS07695	COG2200	EAL domain
ABC12_RS07695	COG2199	diguanylate cyclase activity
ABC12_RS07700	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ABC12_RS07710	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ABC12_RS07715	COG0174	glutamine synthetase
ABC12_RS07725	COG2204	response regulator
ABC12_RS07730	COG0583	DNA-binding transcription factor activity
ABC12_RS07735	COG1741	Belongs to the pirin family
ABC12_RS07740	COG1741	Belongs to the pirin family
ABC12_RS07750	COG3842	ATPase activity
ABC12_RS07755	COG1178	ABC-type Fe3 transport system permease component
ABC12_RS07760	COG1840	ABC-type Fe3 transport system, periplasmic component
ABC12_RS07770	COG0583	DNA-binding transcription factor activity
ABC12_RS07780	COG0656	L-ascorbic acid biosynthetic process
ABC12_RS07795	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ABC12_RS07800	COG0583	DNA-binding transcription factor activity
ABC12_RS07815	COG0783	Belongs to the Dps family
ABC12_RS07835	COG0463	Glycosyl transferase, family 2
ABC12_RS07855	COG0438	transferase activity, transferring glycosyl groups
ABC12_RS07870	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ABC12_RS07895	COG0300	oxidoreductase activity
ABC12_RS07940	COG0861	Integral membrane protein TerC family
ABC12_RS07945	COG1028	Short-chain dehydrogenase reductase Sdr
ABC12_RS07965	COG0714	Associated with various cellular activities
ABC12_RS08000	COG3119	arylsulfatase activity
ABC12_RS08025	COG2197	response regulator
ABC12_RS08035	COG2944	sequence-specific DNA binding
ABC12_RS08040	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
ABC12_RS08045	COG0625	glutathione transferase activity
ABC12_RS08075	COG0179	Fumarylacetoacetate (FAA) hydrolase
ABC12_RS08080	COG1028	Short-chain dehydrogenase reductase Sdr
ABC12_RS08125	COG0431	NADPH-dependent FMN reductase
ABC12_RS08155	COG1028	Short-chain dehydrogenase reductase Sdr
ABC12_RS08160	COG0583	DNA-binding transcription factor activity
ABC12_RS08175	COG3181	Tripartite tricarboxylate transporter family receptor
ABC12_RS08180	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ABC12_RS08180	COG2111	Na H antiporter
ABC12_RS08185	COG1006	Multisubunit Na H antiporter MnhC subunit
ABC12_RS08190	COG0651	ATP synthesis coupled electron transport
ABC12_RS08195	COG1863	multisubunit Na H antiporter MnhE subunit
ABC12_RS08200	COG2212	antiporter activity
ABC12_RS08225	COG0590	tRNA wobble adenosine to inosine editing
ABC12_RS08230	COG1619	proteins homologs of microcin C7 resistance protein MccF
ABC12_RS08235	COG1024	Enoyl-CoA hydratase
ABC12_RS08250	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ABC12_RS08255	COG0488	(ABC) transporter
ABC12_RS08290	COG1017	nitric oxide dioxygenase activity
ABC12_RS08290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ABC12_RS08295	COG1959	2 iron, 2 sulfur cluster binding
ABC12_RS08300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ABC12_RS08320	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ABC12_RS08325	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ABC12_RS08330	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ABC12_RS08335	COG0084	hydrolase, TatD family'
ABC12_RS08350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ABC12_RS08360	COG1126	abc transporter atp-binding protein
ABC12_RS08365	COG0010	Belongs to the arginase family
ABC12_RS08370	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ABC12_RS08375	COG1012	belongs to the aldehyde dehydrogenase family
ABC12_RS08385	COG0028	Belongs to the TPP enzyme family
ABC12_RS08395	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ABC12_RS08395	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ABC12_RS08405	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ABC12_RS08420	COG3189	MarR family transcriptional regulator
ABC12_RS08425	COG2010	Cytochrome c
ABC12_RS08450	COG4336	lyase activity
ABC12_RS08460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ABC12_RS08460	COG2205	protein histidine kinase activity
ABC12_RS08465	COG2197	response regulator
ABC12_RS08470	COG3210	domain, Protein
ABC12_RS08470	COG3064	Membrane
ABC12_RS08470	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
ABC12_RS08480	COG3121	Chaperone
ABC12_RS08485	COG3188	usher protein
ABC12_RS08490	COG3539	Fimbrial protein
ABC12_RS08495	COG2831	hemolysin activation secretion protein
ABC12_RS08510	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ABC12_RS08535	COG0583	DNA-binding transcription factor activity
ABC12_RS08560	COG0668	transmembrane transport
ABC12_RS08580	COG0483	inositol monophosphate 1-phosphatase activity
ABC12_RS08585	COG1253	flavin adenine dinucleotide binding
ABC12_RS08590	COG1968	undecaprenyl-diphosphatase activity
ABC12_RS08595	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ABC12_RS08610	COG0215	cysteine-tRNA ligase activity
ABC12_RS08620	COG0825	malonyl-CoA metabolic process
ABC12_RS08630	COG0037	tRNA processing
ABC12_RS08635	COG0527	aspartate kinase activity
ABC12_RS08660	COG1250	3-hydroxyacyl-CoA dehydrogenase
ABC12_RS08665	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ABC12_RS08665	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ABC12_RS08680	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ABC12_RS08685	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
ABC12_RS08690	COG1028	Short-chain dehydrogenase reductase Sdr
ABC12_RS08700	COG0583	DNA-binding transcription factor activity
ABC12_RS08730	COG3842	ATPase activity
ABC12_RS08740	COG1902	pentaerythritol trinitrate reductase activity
ABC12_RS08740	COG0446	pyridine nucleotide-disulphide oxidoreductase
ABC12_RS08745	COG1414	Transcriptional regulator
ABC12_RS08750	COG1832	CoA-binding protein
ABC12_RS08760	COG0251	oxidation-reduction process
ABC12_RS08785	COG1902	pentaerythritol trinitrate reductase activity
ABC12_RS08795	COG1215	transferase activity, transferring glycosyl groups
ABC12_RS08800	COG1649	PFAM Uncharacterised BCR, COG1649
ABC12_RS08800	COG0726	polysaccharide deacetylase
ABC12_RS08820	COG1846	Transcriptional regulator
ABC12_RS08835	COG3468	outer membrane autotransporter barrel domain protein
ABC12_RS08840	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ABC12_RS08850	COG0556	nucleotide-excision repair
ABC12_RS08855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ABC12_RS08865	COG1104	cysteine desulfurase activity
ABC12_RS08870	COG0822	iron-sulfur transferase activity
ABC12_RS08875	COG0316	Belongs to the HesB IscA family
ABC12_RS08880	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ABC12_RS08885	COG0443	Heat shock 70 kDa protein
ABC12_RS08890	COG0633	Ferredoxin
ABC12_RS08910	COG1024	Enoyl-CoA hydratase
ABC12_RS08925	COG3395	kinase activity
ABC12_RS08930	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ABC12_RS08945	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ABC12_RS08955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ABC12_RS08980	COG0747	negative chemotaxis
ABC12_RS08985	COG0601	transmembrane transport
ABC12_RS08990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ABC12_RS08995	COG4172	Belongs to the ABC transporter superfamily
ABC12_RS09000	COG0154	amidase activity
ABC12_RS09045	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ABC12_RS09050	COG0425	Belongs to the sulfur carrier protein TusA family
ABC12_RS09060	COG0228	four-way junction DNA binding
ABC12_RS09065	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ABC12_RS09070	COG0336	Belongs to the RNA methyltransferase TrmD family
ABC12_RS09075	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ABC12_RS09095	COG0642	Histidine kinase
ABC12_RS09110	COG0525	valine-tRNA ligase activity
ABC12_RS09115	COG0105	UTP biosynthetic process
ABC12_RS09120	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ABC12_RS09130	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ABC12_RS09135	COG0124	histidyl-tRNA synthetase
ABC12_RS09140	COG2976	Protein conserved in bacteria
ABC12_RS09145	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ABC12_RS09150	COG1160	GTP binding
ABC12_RS09155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ABC12_RS09160	COG1923	regulation of RNA biosynthetic process
ABC12_RS09165	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ABC12_RS09170	COG0330	HflC and HflK could
ABC12_RS09175	COG0330	HflC and HflK could
ABC12_RS09180	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ABC12_RS09185	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ABC12_RS09190	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ABC12_RS09195	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ABC12_RS09205	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ABC12_RS09240	COG0628	permease
ABC12_RS09245	COG0842	Transport permease protein
ABC12_RS09250	COG1131	(ABC) transporter
ABC12_RS09320	COG0156	8-amino-7-oxononanoate synthase activity
ABC12_RS09330	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ABC12_RS09330	COG4106	trans-aconitate 2-methyltransferase activity
ABC12_RS09335	COG1380	Effector of murein hydrolase LrgA
ABC12_RS09355	COG3284	Transcriptional regulator
ABC12_RS09360	COG1012	belongs to the aldehyde dehydrogenase family
ABC12_RS09375	COG2733	membrane
ABC12_RS09380	COG0583	DNA-binding transcription factor activity
ABC12_RS09385	COG0384	phenazine biosynthesis protein PhzF
ABC12_RS09390	COG5507	3-demethylubiquinone-9 3-methyltransferase
ABC12_RS09395	COG2169	Transcriptional regulator
ABC12_RS09425	COG0659	secondary active sulfate transmembrane transporter activity
ABC12_RS09450	COG1132	(ABC) transporter
ABC12_RS09495	COG2207	Transcriptional regulator
ABC12_RS09630	COG2346	COG2346, Truncated hemoglobins
ABC12_RS09675	COG0183	Belongs to the thiolase family
ABC12_RS09690	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ABC12_RS09695	COG0633	Ferredoxin
ABC12_RS09705	COG1024	Enoyl-CoA hydratase
ABC12_RS09715	COG4638	Rieske (2fe-2S)
ABC12_RS09725	COG0559	Belongs to the binding-protein-dependent transport system permease family
ABC12_RS09745	COG2224	Isocitrate lyase
ABC12_RS09750	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ABC12_RS09750	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ABC12_RS09765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ABC12_RS09770	COG0322	excinuclease ABC activity
ABC12_RS09775	COG1472	Belongs to the glycosyl hydrolase 3 family
ABC12_RS09780	COG0736	holo-[acyl-carrier-protein] synthase activity
ABC12_RS09785	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ABC12_RS09795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ABC12_RS09800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ABC12_RS09825	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ABC12_RS09840	COG2032	superoxide dismutase activity
ABC12_RS09855	COG1024	Enoyl-CoA hydratase
ABC12_RS09865	COG1802	Transcriptional regulator
ABC12_RS09875	COG0183	Belongs to the thiolase family
ABC12_RS09880	COG1942	4-Oxalocrotonate Tautomerase
ABC12_RS09890	COG4176	ABC-type proline glycine betaine transport system permease component
ABC12_RS09905	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ABC12_RS09910	COG2814	Major facilitator Superfamily
ABC12_RS09915	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ABC12_RS09920	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ABC12_RS09950	COG2814	Major facilitator Superfamily
ABC12_RS09955	COG0495	leucyl-tRNA aminoacylation
ABC12_RS09970	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ABC12_RS09980	COG0154	amidase activity
ABC12_RS09985	COG1250	3-hydroxyacyl-CoA dehydrogenase
ABC12_RS10040	COG0427	acetyl-CoA hydrolase
ABC12_RS10045	COG0583	DNA-binding transcription factor activity
ABC12_RS10065	COG0730	response to heat
ABC12_RS10070	COG0697	spore germination
ABC12_RS10105	COG2885	chlorophyll binding
ABC12_RS10130	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ABC12_RS10135	COG3384	dioxygenase
ABC12_RS10150	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ABC12_RS10155	COG3474	cytochrome
ABC12_RS10165	COG1595	DNA-templated transcription, initiation
ABC12_RS10180	COG2204	response regulator
ABC12_RS10220	COG4964	Belongs to the GSP D family
ABC12_RS10270	COG1846	Transcriptional regulator
ABC12_RS10275	COG4172	Belongs to the ABC transporter superfamily
ABC12_RS10280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ABC12_RS10285	COG0601	transmembrane transport
ABC12_RS10290	COG0747	negative chemotaxis
ABC12_RS10300	COG0598	Magnesium transport protein CorA
ABC12_RS10305	COG0210	DNA helicase
ABC12_RS10320	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ABC12_RS10325	COG1012	belongs to the aldehyde dehydrogenase family
ABC12_RS10330	COG0483	inositol monophosphate 1-phosphatase activity
ABC12_RS10335	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ABC12_RS10345	COG1045	serine acetyltransferase
ABC12_RS10350	COG0166	Belongs to the GPI family
ABC12_RS10365	COG2197	response regulator
ABC12_RS10385	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ABC12_RS10400	COG1960	acyl-CoA dehydrogenase activity
ABC12_RS10405	COG1028	Short-chain dehydrogenase reductase Sdr
ABC12_RS10410	COG0183	Belongs to the thiolase family
ABC12_RS10420	COG1024	Enoyl-CoA hydratase
ABC12_RS10435	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ABC12_RS10440	COG0583	DNA-binding transcription factor activity
ABC12_RS10445	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ABC12_RS10450	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ABC12_RS10455	COG0740	serine-type endopeptidase activity
ABC12_RS10460	COG0544	peptidyl-prolyl cis-trans isomerase activity
ABC12_RS10480	COG1278	Cold shock
ABC12_RS10515	COG2171	N-acyltransferase activity
ABC12_RS10520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ABC12_RS10525	COG2890	protein-(glutamine-N5) methyltransferase activity
ABC12_RS10530	COG0488	(ABC) transporter
ABC12_RS10535	COG4771	TonB-dependent receptor
ABC12_RS10540	COG0210	DNA helicase
ABC12_RS10560	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ABC12_RS10565	COG0196	riboflavin kinase activity
ABC12_RS10570	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ABC12_RS10575	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ABC12_RS10580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ABC12_RS10590	COG1522	sequence-specific DNA binding
ABC12_RS10610	COG2951	lytic endotransglycosylase activity
ABC12_RS10615	COG2833	Protein of unknown function (DUF455)
ABC12_RS10635	COG0189	ligase activity
ABC12_RS10635	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ABC12_RS10640	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ABC12_RS10640	COG1181	Belongs to the D-alanine--D-alanine ligase family
ABC12_RS10645	COG3237	CsbD-like
ABC12_RS10655	COG2823	Periplasmic or secreted lipoprotein
ABC12_RS10665	COG4181	ATPase activity
ABC12_RS10675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ABC12_RS10680	COG0584	glycerophosphoryl diester phosphodiesterase
ABC12_RS10685	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ABC12_RS10695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ABC12_RS10695	COG0678	peroxiredoxin activity
ABC12_RS10705	COG0789	Transcriptional regulator
ABC12_RS10710	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ABC12_RS10740	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ABC12_RS10745	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ABC12_RS10755	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ABC12_RS10760	COG2252	PERMEase
ABC12_RS10770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ABC12_RS10805	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ABC12_RS10810	COG2358	TRAP transporter, solute receptor (TAXI family
ABC12_RS10845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ABC12_RS10850	COG1366	Belongs to the anti-sigma-factor antagonist family
ABC12_RS10855	COG2172	sigma factor antagonist activity
ABC12_RS10860	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ABC12_RS10870	COG2770	Histidine kinase
ABC12_RS10870	COG2208	phosphoserine phosphatase activity
ABC12_RS10895	COG1595	DNA-templated transcription, initiation
ABC12_RS10910	COG4792	protein secretion
ABC12_RS10915	COG4791	protein targeting
ABC12_RS10920	COG4794	Type iii secretion
ABC12_RS10925	COG4790	Type iii secretion
ABC12_RS10960	COG4669	(LipO)protein
ABC12_RS11025	COG4789	Type iii secretion
ABC12_RS11055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ABC12_RS11060	COG0840	transmembrane signaling receptor activity
ABC12_RS11065	COG2233	PERMEase
ABC12_RS11085	COG0492	ferredoxin-NADP+ reductase activity
ABC12_RS11090	COG1840	ABC-type Fe3 transport system, periplasmic component
ABC12_RS11095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ABC12_RS11100	COG1178	ABC-type Fe3 transport system permease component
ABC12_RS11105	COG3842	ATPase activity
ABC12_RS11110	COG0583	DNA-binding transcription factor activity
ABC12_RS11130	COG0501	Belongs to the peptidase M48B family
ABC12_RS11140	COG0697	spore germination
ABC12_RS11150	COG1846	Transcriptional regulator
ABC12_RS11160	COG1566	PFAM secretion protein HlyD family protein
ABC12_RS11165	COG2814	Major facilitator Superfamily
ABC12_RS11170	COG0473	3-isopropylmalate dehydrogenase activity
ABC12_RS11180	COG0747	negative chemotaxis
ABC12_RS11190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ABC12_RS11205	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ABC12_RS11230	COG1012	belongs to the aldehyde dehydrogenase family
ABC12_RS11240	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ABC12_RS11245	COG1115	amino acid carrier protein
ABC12_RS11250	COG0433	COG0433 Predicted ATPase
ABC12_RS11255	COG0217	transcriptional regulatory protein
ABC12_RS11260	COG0151	Belongs to the GarS family
ABC12_RS11265	COG0408	coproporphyrinogen oxidase activity
ABC12_RS11270	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ABC12_RS11275	COG0799	negative regulation of ribosome biogenesis
ABC12_RS11280	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ABC12_RS11285	COG0424	maF-like protein
ABC12_RS11290	COG3468	outer membrane autotransporter barrel domain protein
ABC12_RS11330	COG1530	ribonuclease E activity
ABC12_RS11335	COG0077	Prephenate dehydratase
ABC12_RS11350	COG1132	(ABC) transporter
ABC12_RS11355	COG0859	PFAM glycosyl transferase family 9
ABC12_RS11380	COG2194	sulfuric ester hydrolase activity
ABC12_RS11385	COG0438	transferase activity, transferring glycosyl groups
ABC12_RS11390	COG0463	Glycosyl transferase, family 2
ABC12_RS11395	COG0726	polysaccharide deacetylase
ABC12_RS11400	COG0438	transferase activity, transferring glycosyl groups
ABC12_RS11415	COG1643	Atp-dependent helicase
ABC12_RS11420	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ABC12_RS11420	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ABC12_RS11425	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ABC12_RS11435	COG0704	Plays a role in the regulation of phosphate uptake
ABC12_RS11440	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ABC12_RS11445	COG1960	acyl-CoA dehydrogenase activity
ABC12_RS11470	COG1177	transmembrane transport
ABC12_RS11475	COG1176	ABC-type spermidine putrescine transport system, permease component I
ABC12_RS11480	COG3842	ATPase activity
ABC12_RS11485	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ABC12_RS11500	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ABC12_RS11505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ABC12_RS11515	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ABC12_RS11515	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ABC12_RS11535	COG0372	Belongs to the citrate synthase family
ABC12_RS11540	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ABC12_RS11545	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ABC12_RS11550	COG1053	succinate dehydrogenase
ABC12_RS11555	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ABC12_RS11560	COG2009	succinate dehydrogenase
ABC12_RS11565	COG2188	Transcriptional regulator
ABC12_RS11570	COG0039	L-malate dehydrogenase activity
ABC12_RS11600	COG1981	membrane
ABC12_RS11625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ABC12_RS11635	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ABC12_RS11665	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ABC12_RS11670	COG0148	phosphopyruvate hydratase activity
ABC12_RS11680	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ABC12_RS11685	COG0504	CTP synthase activity
ABC12_RS11710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ABC12_RS11720	COG0747	negative chemotaxis
ABC12_RS11725	COG4172	Belongs to the ABC transporter superfamily
ABC12_RS11730	COG1446	asparaginase
ABC12_RS11760	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ABC12_RS11775	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ABC12_RS11780	COG0697	spore germination
ABC12_RS11785	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ABC12_RS11795	COG3193	protein, possibly involved in utilization of glycolate and propanediol
ABC12_RS11800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ABC12_RS11805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ABC12_RS11810	COG0791	NLP P60 protein
ABC12_RS11825	COG0583	DNA-binding transcription factor activity
ABC12_RS11840	COG0583	DNA-binding transcription factor activity
ABC12_RS11850	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ABC12_RS11865	COG0670	Belongs to the BI1 family
ABC12_RS11870	COG3181	Tripartite tricarboxylate transporter family receptor
ABC12_RS11880	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ABC12_RS11890	COG1381	Involved in DNA repair and RecF pathway recombination
ABC12_RS11895	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ABC12_RS11900	COG0571	ribonuclease III activity
ABC12_RS11905	COG0681	Belongs to the peptidase S26 family
ABC12_RS11910	COG0481	GTPase activity
ABC12_RS11915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ABC12_RS11940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ABC12_RS11945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ABC12_RS11960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ABC12_RS11965	COG0416	fatty acid biosynthetic process
ABC12_RS11970	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ABC12_RS11975	COG1399	metal-binding, possibly nucleic acid-binding protein
ABC12_RS11980	COG0424	maF-like protein
ABC12_RS11990	COG3023	N-Acetylmuramoyl-L-alanine amidase
ABC12_RS11995	COG1289	transmembrane transporter activity
ABC12_RS12005	COG3022	response to hydroperoxide
ABC12_RS12020	COG0135	phosphoribosylanthranilate isomerase activity
ABC12_RS12035	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ABC12_RS12040	COG0101	tRNA pseudouridine synthase activity
ABC12_RS12050	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ABC12_RS12055	COG0473	3-isopropylmalate dehydrogenase activity
ABC12_RS12060	COG0066	3-isopropylmalate dehydratase activity
ABC12_RS12065	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ABC12_RS12075	COG1122	ATPase activity
ABC12_RS12105	COG0437	4 iron, 4 sulfur cluster binding
ABC12_RS12110	COG3383	formate dehydrogenase (NAD+) activity
ABC12_RS12110	COG0243	molybdopterin cofactor binding
ABC12_RS12140	COG0489	protein tyrosine kinase activity
ABC12_RS12145	COG0746	molybdenum cofactor guanylyltransferase activity
ABC12_RS12150	COG0303	'Molybdopterin
ABC12_RS12155	COG1763	Mo-molybdopterin cofactor biosynthetic process
ABC12_RS12165	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ABC12_RS12170	COG5001	Diguanylate cyclase
ABC12_RS12190	COG3842	ATPase activity
ABC12_RS12200	COG0406	alpha-ribazole phosphatase activity
ABC12_RS12210	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ABC12_RS12215	COG0505	Belongs to the CarA family
ABC12_RS12220	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ABC12_RS12250	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ABC12_RS12255	COG1960	acyl-CoA dehydrogenase activity
ABC12_RS12265	COG2867	negative regulation of translational initiation
ABC12_RS12275	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ABC12_RS12280	COG3706	GGDEF domain
ABC12_RS12285	COG0330	HflC and HflK could
ABC12_RS12300	COG0519	Catalyzes the synthesis of GMP from XMP
ABC12_RS12300	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ABC12_RS12310	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ABC12_RS12315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ABC12_RS12320	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ABC12_RS12325	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ABC12_RS12335	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ABC12_RS12340	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ABC12_RS12345	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ABC12_RS12350	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ABC12_RS12355	COG0750	zinc metalloprotease
ABC12_RS12360	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ABC12_RS12370	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ABC12_RS12375	COG0233	cytoplasmic translational termination
ABC12_RS12380	COG0528	UMP kinase activity
ABC12_RS12385	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ABC12_RS12390	COG0052	Belongs to the universal ribosomal protein uS2 family
ABC12_RS12395	COG0024	Methionine aminopeptidase
ABC12_RS12400	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ABC12_RS12430	COG0285	dihydrofolate synthase activity
ABC12_RS12465	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ABC12_RS12475	COG1677	Flagellar hook-basal body complex protein FliE
ABC12_RS12485	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ABC12_RS12495	COG1157	protein secretion by the type III secretion system
ABC12_RS12520	COG1580	Controls the rotational direction of flagella during chemotaxis
ABC12_RS12540	COG1338	Plays a role in the flagellum-specific transport system
ABC12_RS12560	COG0840	transmembrane signaling receptor activity
ABC12_RS12565	COG0840	transmembrane signaling receptor activity
ABC12_RS12570	COG0840	transmembrane signaling receptor activity
ABC12_RS12580	COG1256	bacterial-type flagellum assembly
ABC12_RS12590	COG1706	bacterial-type flagellum-dependent cell motility
ABC12_RS12595	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ABC12_RS12610	COG1749	Flagellar hook protein flgE
ABC12_RS12620	COG1558	bacterial-type flagellum-dependent cell motility
ABC12_RS12625	COG1815	bacterial-type flagellum-dependent cell motility
ABC12_RS12665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ABC12_RS12670	COG0765	amino acid transport
ABC12_RS12675	COG1126	abc transporter atp-binding protein
ABC12_RS12690	COG4948	Mandelate Racemase Muconate Lactonizing
ABC12_RS12695	COG3181	Tripartite tricarboxylate transporter family receptor
ABC12_RS12705	COG0066	3-isopropylmalate dehydratase activity
ABC12_RS12720	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ABC12_RS12730	COG3181	Tripartite tricarboxylate transporter family receptor
ABC12_RS12740	COG1802	Transcriptional regulator
ABC12_RS12755	COG0583	DNA-binding transcription factor activity
ABC12_RS12775	COG1695	Transcriptional regulator
ABC12_RS12785	COG3568	Endonuclease Exonuclease Phosphatase
ABC12_RS12790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ABC12_RS12805	COG0392	lysyltransferase activity
ABC12_RS12845	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ABC12_RS12855	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ABC12_RS12875	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ABC12_RS12905	COG0667	Aldo Keto reductase
ABC12_RS12920	COG2259	Doxx family
ABC12_RS12955	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ABC12_RS12975	COG0386	Belongs to the glutathione peroxidase family
ABC12_RS12980	COG0625	glutathione transferase activity
ABC12_RS13005	COG0688	phosphatidylethanolamine metabolic process
ABC12_RS13015	COG1464	Belongs to the NlpA lipoprotein family
ABC12_RS13030	COG2363	Small membrane protein
ABC12_RS13055	COG3842	ATPase activity
ABC12_RS13060	COG0395	ABC-type sugar transport system, permease component
ABC12_RS13065	COG1175	transmembrane transport
ABC12_RS13070	COG1653	transport
ABC12_RS13080	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ABC12_RS13095	COG0559	Belongs to the binding-protein-dependent transport system permease family
ABC12_RS13115	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ABC12_RS13130	COG0697	spore germination
ABC12_RS13145	COG2311	Membrane
ABC12_RS13170	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ABC12_RS13180	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ABC12_RS13185	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ABC12_RS13190	COG1760	l-serine dehydratase
ABC12_RS13195	COG1283	sodium-dependent phosphate transmembrane transporter activity
ABC12_RS13200	COG0412	Dienelactone hydrolase
ABC12_RS13215	COG1611	Belongs to the LOG family
ABC12_RS13235	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ABC12_RS13240	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ABC12_RS13245	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ABC12_RS13250	COG0195	Participates in both transcription termination and antitermination
ABC12_RS13250	COG2251	uridine kinase activity
ABC12_RS13255	COG0779	Required for maturation of 30S ribosomal subunits
ABC12_RS13260	COG1187	pseudouridine synthase activity
ABC12_RS13265	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ABC12_RS13275	COG0583	DNA-binding transcription factor activity
ABC12_RS13285	COG0523	cobalamin synthesis protein
ABC12_RS13305	COG0625	glutathione transferase activity
ABC12_RS13310	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ABC12_RS13315	COG1047	Peptidyl-prolyl cis-trans
ABC12_RS13320	COG2003	Belongs to the UPF0758 family
ABC12_RS13325	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ABC12_RS13330	COG3483	tryptophan 2,3-dioxygenase activity
ABC12_RS13335	COG0254	rRNA binding
ABC12_RS13345	COG0534	Mate efflux family protein
ABC12_RS13365	COG2304	oxidoreductase activity
ABC12_RS13385	COG1028	Short-chain dehydrogenase reductase Sdr
ABC12_RS13390	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ABC12_RS13395	COG1562	ergosterol biosynthetic process
ABC12_RS13400	COG1562	ergosterol biosynthetic process
ABC12_RS13405	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
ABC12_RS13405	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
ABC12_RS13410	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ABC12_RS13420	COG0842	Transport permease protein
ABC12_RS13425	COG1131	(ABC) transporter
ABC12_RS13445	COG1477	protein flavinylation
ABC12_RS13460	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ABC12_RS13475	COG5564	TIM-barrel signal transduction protein
ABC12_RS13480	COG5441	Belongs to the UPF0261 family
ABC12_RS13490	COG3468	outer membrane autotransporter barrel domain protein
ABC12_RS13495	COG3468	outer membrane autotransporter barrel domain protein
ABC12_RS13510	COG0542	response to heat
ABC12_RS13515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ABC12_RS13530	COG0494	nUDIX hydrolase
ABC12_RS13535	COG3530	Putative quorum-sensing-regulated virulence factor
ABC12_RS13545	COG1595	DNA-templated transcription, initiation
ABC12_RS13550	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ABC12_RS13585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ABC12_RS13590	COG0765	amino acid transport
ABC12_RS13595	COG0765	amino acid transport
ABC12_RS13620	COG3539	Fimbrial protein
ABC12_RS13630	COG2050	protein possibly involved in aromatic compounds catabolism
ABC12_RS13635	COG1024	Enoyl-CoA hydratase
ABC12_RS13640	COG1012	belongs to the aldehyde dehydrogenase family
ABC12_RS13650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ABC12_RS13655	COG2151	metal-sulfur cluster biosynthetic enzyme
ABC12_RS13660	COG3396	Phenylacetate-CoA oxygenase
ABC12_RS13665	COG3460	Phenylacetate-CoA oxygenase
ABC12_RS13670	COG3396	Phenylacetate-CoA oxygenase
ABC12_RS13675	COG3327	negative regulation of DNA-templated transcription, initiation
ABC12_RS13685	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ABC12_RS13690	COG0501	Belongs to the peptidase M48B family
ABC12_RS13695	COG1162	GTPase activity
ABC12_RS13700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ABC12_RS13705	COG0601	transmembrane transport
ABC12_RS13710	COG0747	negative chemotaxis
ABC12_RS13755	COG0668	transmembrane transport
ABC12_RS13760	COG0165	Argininosuccinate lyase
ABC12_RS13780	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ABC12_RS13785	COG0303	'Molybdopterin
ABC12_RS13790	COG0521	Mo-molybdopterin cofactor biosynthetic process
ABC12_RS13805	COG0315	cyclic pyranopterin monophosphate synthase activity
ABC12_RS13815	COG0412	Dienelactone hydrolase
ABC12_RS13825	COG0678	peroxiredoxin activity
ABC12_RS13835	COG0697	spore germination
ABC12_RS13840	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ABC12_RS13865	COG0789	Transcriptional regulator
ABC12_RS13885	COG1028	Short-chain dehydrogenase reductase Sdr
ABC12_RS13895	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ABC12_RS13900	COG1845	cytochrome c oxidase, subunit III
ABC12_RS13905	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ABC12_RS13915	COG0477	Major facilitator Superfamily
ABC12_RS13945	COG3468	outer membrane autotransporter barrel domain protein
ABC12_RS13955	COG1309	transcriptional regulator
ABC12_RS13960	COG2271	Major facilitator Superfamily
ABC12_RS13995	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ABC12_RS13995	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ABC12_RS13995	COG0506	proline dehydrogenase activity
ABC12_RS14005	COG3008	intermembrane lipid transfer
ABC12_RS14005	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ABC12_RS14010	COG2995	paraquat-inducible protein a
ABC12_RS14015	COG0542	response to heat
ABC12_RS14020	COG4953	penicillin-binding protein 1C
ABC12_RS14030	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ABC12_RS14035	COG1278	Cold shock
ABC12_RS14045	COG0183	Belongs to the thiolase family
ABC12_RS14050	COG0038	chloride channel
ABC12_RS14055	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ABC12_RS14060	COG1570	exodeoxyribonuclease VII activity
ABC12_RS14070	COG0811	peptide transport
ABC12_RS14075	COG0848	biopolymer transport protein
ABC12_RS14080	COG1663	tetraacyldisaccharide 4'-kinase activity
ABC12_RS14085	COG2835	tetraacyldisaccharide 4'-kinase activity
ABC12_RS14090	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ABC12_RS14095	COG0563	adenylate kinase activity
ABC12_RS14105	COG0728	peptidoglycan biosynthetic process
ABC12_RS14115	COG0268	Binds directly to 16S ribosomal RNA
ABC12_RS14145	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
ABC12_RS14170	COG0436	Aminotransferase
ABC12_RS14175	COG3737	Protein of unknown function (DUF498/DUF598)
ABC12_RS14180	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ABC12_RS14185	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ABC12_RS14190	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ABC12_RS14200	COG0305	Participates in initiation and elongation during chromosome replication
ABC12_RS14210	COG0359	binds to the 23S rRNA
ABC12_RS14215	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ABC12_RS14220	COG2965	DNA replication, synthesis of RNA primer
ABC12_RS14225	COG0360	Binds together with S18 to 16S ribosomal RNA
ABC12_RS14230	COG1469	GTP cyclohydrolase I activity
ABC12_RS14235	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ABC12_RS14240	COG0142	geranyltranstransferase activity
ABC12_RS14245	COG1722	exodeoxyribonuclease VII activity
ABC12_RS14255	COG3181	Tripartite tricarboxylate transporter family receptor
ABC12_RS14275	COG2239	Acts as a magnesium transporter
ABC12_RS14285	COG2855	membrane
ABC12_RS14295	COG1473	amidohydrolase
ABC12_RS14300	COG0318	PFAM AMP-dependent synthetase and ligase
ABC12_RS14325	COG1501	Belongs to the glycosyl hydrolase 31 family
ABC12_RS14330	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ABC12_RS14335	COG2011	ABC-type metal ion transport system permease component
ABC12_RS14355	COG1454	alcohol dehydrogenase
ABC12_RS14385	COG2186	Transcriptional regulator
ABC12_RS14390	COG3181	Tripartite tricarboxylate transporter family receptor
ABC12_RS14410	COG1175	transmembrane transport
ABC12_RS14415	COG0395	ABC-type sugar transport system, permease component
ABC12_RS14420	COG3842	ATPase activity
ABC12_RS14425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ABC12_RS14435	COG1653	transport
ABC12_RS14455	COG2818	Glycosylase
ABC12_RS14460	COG2982	Protein involved in outer membrane biogenesis
ABC12_RS14470	COG1309	transcriptional regulator
ABC12_RS14475	COG1028	Short-chain dehydrogenase reductase Sdr
ABC12_RS14535	COG0583	DNA-binding transcription factor activity
ABC12_RS14540	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ABC12_RS14545	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ABC12_RS14560	COG1028	Short-chain dehydrogenase reductase Sdr
ABC12_RS14565	COG0477	Major facilitator Superfamily
ABC12_RS14575	COG0583	DNA-binding transcription factor activity
ABC12_RS14580	COG1448	Aminotransferase
ABC12_RS14585	COG1418	mRNA catabolic process
ABC12_RS14610	COG1063	alcohol dehydrogenase
ABC12_RS14630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ABC12_RS14640	COG0318	PFAM AMP-dependent synthetase and ligase
ABC12_RS14650	COG1522	sequence-specific DNA binding
ABC12_RS14655	COG3181	Tripartite tricarboxylate transporter family receptor
ABC12_RS14660	COG0307	riboflavin synthase, alpha
ABC12_RS14665	COG0154	amidase activity
ABC12_RS14685	COG2807	transmembrane transport
ABC12_RS14690	COG0590	tRNA wobble adenosine to inosine editing
ABC12_RS14700	COG0583	DNA-binding transcription factor activity
ABC12_RS14715	COG1902	pentaerythritol trinitrate reductase activity
ABC12_RS14735	COG0559	Belongs to the binding-protein-dependent transport system permease family
ABC12_RS14740	COG0251	oxidation-reduction process
ABC12_RS14745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ABC12_RS14755	COG1414	Transcriptional regulator
ABC12_RS14760	COG1028	Short-chain dehydrogenase reductase Sdr
ABC12_RS14775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ABC12_RS14790	COG1024	Enoyl-CoA hydratase
ABC12_RS14795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ABC12_RS14800	COG0154	amidase activity
ABC12_RS14840	COG3909	cytochrome
ABC12_RS14845	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ABC12_RS14850	COG0625	glutathione transferase activity
ABC12_RS14855	COG0730	response to heat
ABC12_RS14860	COG0482	sulfurtransferase activity
ABC12_RS14865	COG0583	DNA-binding transcription factor activity
ABC12_RS14885	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ABC12_RS14910	COG2819	hydrolase of the alpha beta superfamily
ABC12_RS14915	COG0247	lactate metabolic process
ABC12_RS14920	COG0277	FAD linked oxidase domain protein
ABC12_RS14925	COG0277	FAD linked oxidase domain protein
ABC12_RS14930	COG0277	FAD linked oxidase domain protein
ABC12_RS14935	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
ABC12_RS14935	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
ABC12_RS14935	COG3210	domain, Protein
ABC12_RS14935	COG3064	Membrane
ABC12_RS14935	COG3210	domain, Protein
ABC12_RS14935	COG3064	Membrane
ABC12_RS14940	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ABC12_RS14945	COG0312	modulator of DNA gyrase
ABC12_RS14980	COG1666	GTP binding
ABC12_RS15025	COG3220	belongs to the UPF0276 family
ABC12_RS15045	COG0640	Transcriptional regulator
ABC12_RS15050	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ABC12_RS15055	COG1845	cytochrome c oxidase, subunit III
ABC12_RS15060	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ABC12_RS15070	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
ABC12_RS15105	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ABC12_RS15110	COG0583	DNA-binding transcription factor activity
ABC12_RS15140	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ABC12_RS15140	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ABC12_RS15155	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ABC12_RS15160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ABC12_RS15170	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ABC12_RS15185	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ABC12_RS15190	COG0316	Belongs to the HesB IscA family
ABC12_RS15200	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ABC12_RS15205	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ABC12_RS15210	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ABC12_RS15215	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ABC12_RS15220	COG0312	modulator of DNA gyrase
ABC12_RS15225	COG3028	Belongs to the UPF0307 family
ABC12_RS15240	COG1116	anion transmembrane transporter activity
ABC12_RS15245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ABC12_RS15250	COG1335	isochorismatase
ABC12_RS15255	COG0346	lactoylglutathione lyase activity
ABC12_RS15260	COG0513	Belongs to the DEAD box helicase family
ABC12_RS15265	COG3069	C4-dicarboxylate transmembrane transporter activity
ABC12_RS15270	COG1802	Transcriptional regulator
ABC12_RS15285	COG0045	succinate-CoA ligase (ADP-forming) activity
ABC12_RS15285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ABC12_RS15285	COG1042	CoA-binding domain protein
ABC12_RS15290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ABC12_RS15305	COG1522	sequence-specific DNA binding
ABC12_RS15340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ABC12_RS15345	COG1696	Membrane protein involved in D-alanine export
ABC12_RS15370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ABC12_RS15380	COG2264	protein methyltransferase activity
ABC12_RS15385	COG0439	Biotin carboxylase
ABC12_RS15390	COG0511	ligase activity, forming carbon-carbon bonds
ABC12_RS15395	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ABC12_RS15400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ABC12_RS15405	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ABC12_RS15410	COG3150	esterase
ABC12_RS15415	COG0557	exoribonuclease II activity
ABC12_RS15425	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ABC12_RS15445	COG1522	sequence-specific DNA binding
ABC12_RS15450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ABC12_RS15455	COG1028	Short-chain dehydrogenase reductase Sdr
ABC12_RS15475	COG0653	protein targeting
ABC12_RS15480	COG0739	heme binding
ABC12_RS15490	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ABC12_RS15495	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ABC12_RS15505	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ABC12_RS15510	COG1181	Belongs to the D-alanine--D-alanine ligase family
ABC12_RS15515	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ABC12_RS15520	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ABC12_RS15530	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ABC12_RS15535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ABC12_RS15540	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ABC12_RS15550	COG3116	cell division
ABC12_RS15555	COG0275	rRNA processing
ABC12_RS15560	COG2001	Belongs to the MraZ family
ABC12_RS15570	COG0488	(ABC) transporter
ABC12_RS15575	COG0418	dihydroorotase activity
ABC12_RS15580	COG1473	amidohydrolase
ABC12_RS15630	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ABC12_RS15635	COG4654	Cytochrome c, class I
ABC12_RS15640	COG0129	dihydroxy-acid dehydratase activity
ABC12_RS15645	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ABC12_RS15695	COG2084	Dehydrogenase
ABC12_RS15700	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ABC12_RS15715	COG2096	Adenosyltransferase
ABC12_RS15725	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ABC12_RS15730	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ABC12_RS15740	COG0523	cobalamin synthesis protein
ABC12_RS15745	COG0735	belongs to the Fur family
ABC12_RS15765	COG0803	Belongs to the bacterial solute-binding protein 9 family
ABC12_RS15775	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ABC12_RS15785	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ABC12_RS15795	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ABC12_RS15800	COG1560	Kdo2-lipid A biosynthetic process
ABC12_RS15810	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ABC12_RS15825	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ABC12_RS15830	COG1950	PFAM Membrane protein of
ABC12_RS15845	COG0583	DNA-binding transcription factor activity
ABC12_RS15855	COG0477	Major facilitator Superfamily
ABC12_RS15870	COG0617	tRNA 3'-terminal CCA addition
ABC12_RS15880	COG0513	Belongs to the DEAD box helicase family
ABC12_RS15885	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ABC12_RS15900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ABC12_RS15905	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ABC12_RS15965	COG1280	lysine exporter protein (LysE YggA)
ABC12_RS15980	COG0405	Gamma-glutamyltransferase
ABC12_RS15990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ABC12_RS16020	COG1309	transcriptional regulator
ABC12_RS16030	COG3181	Tripartite tricarboxylate transporter family receptor
ABC12_RS16040	COG0745	RESPONSE REGULATOR receiver
ABC12_RS16105	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ABC12_RS16130	COG0582	viral genome integration into host DNA
ABC12_RS16135	COG0012	GTP binding
ABC12_RS16145	COG0193	aminoacyl-tRNA hydrolase activity
ABC12_RS16150	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ABC12_RS16155	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ABC12_RS16165	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ABC12_RS16170	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ABC12_RS16180	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ABC12_RS16205	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ABC12_RS16215	COG1368	sulfuric ester hydrolase activity
ABC12_RS16220	COG0642	Histidine kinase
ABC12_RS16225	COG0745	RESPONSE REGULATOR receiver
ABC12_RS16230	COG0277	FAD linked oxidase domain protein
ABC12_RS16245	COG0166	Belongs to the GPI family
ABC12_RS16250	COG0438	transferase activity, transferring glycosyl groups
ABC12_RS16255	COG0438	transferase activity, transferring glycosyl groups
ABC12_RS16270	COG0438	transferase activity, transferring glycosyl groups
ABC12_RS16285	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ABC12_RS16290	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ABC12_RS16295	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ABC12_RS16305	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ABC12_RS16315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ABC12_RS16320	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ABC12_RS16330	COG0747	negative chemotaxis
ABC12_RS16335	COG0601	transmembrane transport
ABC12_RS16340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ABC12_RS16360	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ABC12_RS16365	COG0830	nickel cation binding
ABC12_RS16375	COG0804	urea catabolic process
ABC12_RS16380	COG0832	Belongs to the urease beta subunit family
ABC12_RS16390	COG0831	urea catabolic process
ABC12_RS16395	COG0829	nickel cation binding
ABC12_RS16405	COG0633	Ferredoxin
ABC12_RS16420	COG2188	Transcriptional regulator
ABC12_RS16445	COG2719	SpoVR family
ABC12_RS16450	COG2718	Belongs to the UPF0229 family
ABC12_RS16465	COG1028	Short-chain dehydrogenase reductase Sdr
ABC12_RS16470	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ABC12_RS16485	COG1960	acyl-CoA dehydrogenase activity
ABC12_RS16530	COG0183	Belongs to the thiolase family
ABC12_RS16535	COG2030	dehydratase
ABC12_RS16590	COG0328	RNA-DNA hybrid ribonuclease activity
ABC12_RS16595	COG2226	methyltransferase
ABC12_RS16600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ABC12_RS16605	COG1388	LysM domain
ABC12_RS16605	COG0741	lytic transglycosylase activity
ABC12_RS16625	COG2979	Protein of unknown function (DUF533)
ABC12_RS16660	COG1271	oxidase subunit
ABC12_RS16665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ABC12_RS16670	COG0850	regulation of cytokinetic process
ABC12_RS16675	COG2894	cell division
ABC12_RS16680	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ABC12_RS16700	COG0488	(ABC) transporter
ABC12_RS16715	COG0601	transmembrane transport
ABC12_RS16725	COG1215	transferase activity, transferring glycosyl groups
ABC12_RS16740	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ABC12_RS16750	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ABC12_RS16770	COG0318	PFAM AMP-dependent synthetase and ligase
ABC12_RS16775	COG2188	Transcriptional regulator
ABC12_RS16780	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ABC12_RS16785	COG2814	Major facilitator Superfamily
ABC12_RS16795	COG0259	pyridoxamine-phosphate oxidase activity
ABC12_RS16800	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ABC12_RS16815	COG0583	DNA-binding transcription factor activity
ABC12_RS16820	COG1960	acyl-CoA dehydrogenase activity
ABC12_RS16840	COG0134	indole-3-glycerol-phosphate synthase activity
ABC12_RS16845	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ABC12_RS16850	COG0512	Glutamine amidotransferase of anthranilate synthase
ABC12_RS16860	COG0546	phosphoglycolate phosphatase activity
ABC12_RS16865	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ABC12_RS16870	COG2967	ApaG domain
ABC12_RS16875	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ABC12_RS16880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ABC12_RS16885	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ABC12_RS16890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ABC12_RS16900	COG0037	tRNA processing
ABC12_RS16910	COG3634	alkyl hydroperoxide reductase activity
ABC12_RS16915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ABC12_RS16920	COG1024	Enoyl-CoA hydratase
ABC12_RS16945	COG0356	it plays a direct role in the translocation of protons across the membrane
ABC12_RS16955	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ABC12_RS16960	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ABC12_RS16965	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ABC12_RS16970	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ABC12_RS16975	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ABC12_RS16980	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ABC12_RS16990	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ABC12_RS16995	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ABC12_RS17000	COG0210	DNA helicase
ABC12_RS17010	COG2195	Cleaves the N-terminal amino acid of tripeptides
ABC12_RS17020	COG4172	Belongs to the ABC transporter superfamily
ABC12_RS17025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ABC12_RS17030	COG0601	transmembrane transport
ABC12_RS17050	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ABC12_RS17055	COG1024	Enoyl-CoA hydratase
ABC12_RS17060	COG1024	Enoyl-CoA hydratase
ABC12_RS17085	COG1250	3-hydroxyacyl-CoA dehydrogenase
ABC12_RS17115	COG2132	Multicopper oxidase
ABC12_RS17125	COG1250	3-hydroxyacyl-CoA dehydrogenase
ABC12_RS17125	COG1024	Enoyl-CoA hydratase
ABC12_RS17135	COG1414	Transcriptional regulator
ABC12_RS17145	COG0154	amidase activity
ABC12_RS17175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ABC12_RS17180	COG3568	Endonuclease Exonuclease Phosphatase
ABC12_RS17185	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ABC12_RS17220	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ABC12_RS17230	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ABC12_RS17245	COG1137	ATPase activity
ABC12_RS17250	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ABC12_RS17260	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ABC12_RS17265	COG2010	Cytochrome c
ABC12_RS17265	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ABC12_RS17275	COG1660	Displays ATPase and GTPase activities
ABC12_RS17280	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ABC12_RS17315	COG3181	Tripartite tricarboxylate transporter family receptor
ABC12_RS17325	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ABC12_RS17330	COG2890	protein-(glutamine-N5) methyltransferase activity
ABC12_RS17335	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ABC12_RS17340	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ABC12_RS17390	COG1960	acyl-CoA dehydrogenase activity
ABC12_RS17400	COG0183	Belongs to the thiolase family
ABC12_RS17405	COG1522	sequence-specific DNA binding
ABC12_RS17410	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ABC12_RS17430	COG1024	Enoyl-CoA hydratase
ABC12_RS17445	COG0604	alcohol dehydrogenase
ABC12_RS17465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ABC12_RS17475	COG1960	acyl-CoA dehydrogenase activity
ABC12_RS17480	COG1960	acyl-CoA dehydrogenase activity
ABC12_RS17485	COG0277	FAD linked oxidase domain protein
ABC12_RS17495	COG3181	Tripartite tricarboxylate transporter family receptor
ABC12_RS17520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ABC12_RS17530	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ABC12_RS17535	COG3181	Tripartite tricarboxylate transporter family receptor
ABC12_RS17540	COG1960	acyl-CoA dehydrogenase activity
ABC12_RS17560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ABC12_RS17565	COG1024	Enoyl-CoA hydratase
ABC12_RS17570	COG1960	acyl-CoA dehydrogenase activity
ABC12_RS17590	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ABC12_RS17595	COG0022	dehydrogenase e1 component
ABC12_RS17600	COG1024	Enoyl-CoA hydratase
ABC12_RS17605	COG0508	dehydrogenase complex catalyzes the overall conversion of
ABC12_RS17625	COG0683	leucine binding
ABC12_RS17630	COG0559	Belongs to the binding-protein-dependent transport system permease family
ABC12_RS17635	COG0411	ABC transporter
ABC12_RS17645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ABC12_RS17660	COG3181	Tripartite tricarboxylate transporter family receptor
ABC12_RS17690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ABC12_RS17695	COG0793	Belongs to the peptidase S41A family
ABC12_RS17700	COG4942	peptidase
ABC12_RS17705	COG0588	phosphoglycerate mutase activity
ABC12_RS17710	COG1054	Belongs to the UPF0176 family
ABC12_RS17715	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ABC12_RS17720	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ABC12_RS17725	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ABC12_RS17730	COG3181	Tripartite tricarboxylate transporter family receptor
ABC12_RS17745	COG2226	methyltransferase
ABC12_RS17750	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ABC12_RS17765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ABC12_RS17770	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
ABC12_RS17795	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ABC12_RS17820	COG1335	isochorismatase
ABC12_RS17825	COG2309	aminopeptidase activity
ABC12_RS17830	COG0596	Alpha beta hydrolase
ABC12_RS17835	COG3473	Maleate cis-trans isomerase
ABC12_RS17845	COG2068	MobA-Related Protein
ABC12_RS17870	COG2204	response regulator
ABC12_RS17875	COG5000	phosphorelay sensor kinase activity
ABC12_RS17885	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ABC12_RS17885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ABC12_RS17895	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
ABC12_RS17925	COG0583	DNA-binding transcription factor activity
ABC12_RS17940	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ABC12_RS17945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ABC12_RS17950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ABC12_RS17965	COG0758	DNA mediated transformation
ABC12_RS17970	COG1522	sequence-specific DNA binding
ABC12_RS17980	COG0242	peptide deformylase activity
ABC12_RS17995	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ABC12_RS18005	COG0546	phosphoglycolate phosphatase activity
ABC12_RS18025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ABC12_RS18030	COG1942	4-Oxalocrotonate Tautomerase
ABC12_RS18035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ABC12_RS18060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ABC12_RS18080	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ABC12_RS18085	COG1024	Enoyl-CoA hydratase
ABC12_RS18090	COG1414	Transcriptional regulator
ABC12_RS18095	COG0318	PFAM AMP-dependent synthetase and ligase
ABC12_RS18100	COG3181	Tripartite tricarboxylate transporter family receptor
ABC12_RS18130	COG0583	DNA-binding transcription factor activity
ABC12_RS18145	COG3422	double-strand break repair
ABC12_RS18150	COG0330	HflC and HflK could
ABC12_RS18160	COG0251	oxidation-reduction process
ABC12_RS18205	COG3723	Recombinational DNA repair protein, rece pathway
ABC12_RS18240	COG0582	viral genome integration into host DNA
ABC12_RS18265	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ABC12_RS18275	COG0706	membrane insertase activity
ABC12_RS18280	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ABC12_RS18285	COG0594	ribonuclease P activity
ABC12_RS18290	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ABC12_RS18295	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ABC12_RS18310	COG1414	Transcriptional regulator
ABC12_RS18315	COG0154	amidase activity
ABC12_RS18330	COG1304	FMN binding
ABC12_RS18350	COG1960	acyl-CoA dehydrogenase activity
ABC12_RS18370	COG1960	acyl-CoA dehydrogenase activity
ABC12_RS18385	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ABC12_RS18400	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ABC12_RS18405	COG3181	Tripartite tricarboxylate transporter family receptor
ABC12_RS18415	COG2358	TRAP transporter, solute receptor (TAXI family
ABC12_RS18425	COG1629	transport
ABC12_RS18430	COG2922	Belongs to the Smg family
ABC12_RS18455	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
ABC12_RS18460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ABC12_RS18465	COG1028	Short-chain dehydrogenase reductase Sdr
ABC12_RS18470	COG1012	belongs to the aldehyde dehydrogenase family
ABC12_RS18480	COG0028	Belongs to the TPP enzyme family
ABC12_RS18485	COG1522	sequence-specific DNA binding
ABC12_RS18490	COG3781	membrane
ABC12_RS18500	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ABC12_RS18520	COG4206	TonB-dependent receptor
ABC12_RS18525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ABC12_RS18530	COG2022	thiamine diphosphate biosynthetic process
ABC12_RS18535	COG0351	phosphomethylpyrimidine kinase
ABC12_RS18540	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ABC12_RS18555	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ABC12_RS18565	COG0628	permease
ABC12_RS18575	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ABC12_RS18585	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ABC12_RS18590	COG0049	tRNA binding
ABC12_RS18595	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ABC12_RS18600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ABC12_RS18605	COG0051	transcription antitermination factor activity, RNA binding
ABC12_RS18610	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ABC12_RS18615	COG0088	Forms part of the polypeptide exit tunnel
ABC12_RS18620	COG0089	rRNA binding
ABC12_RS18625	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ABC12_RS18630	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ABC12_RS18635	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ABC12_RS18640	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ABC12_RS18645	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ABC12_RS18650	COG0255	Belongs to the universal ribosomal protein uL29 family
ABC12_RS18655	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ABC12_RS18675	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ABC12_RS18680	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ABC12_RS18685	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ABC12_RS18690	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ABC12_RS18695	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ABC12_RS18700	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ABC12_RS18705	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ABC12_RS18710	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ABC12_RS18715	COG1841	ribosomal large subunit assembly
ABC12_RS18720	COG0200	Binds to the 23S rRNA
ABC12_RS18725	COG0201	protein transport
ABC12_RS18730	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ABC12_RS18735	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ABC12_RS18740	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ABC12_RS18745	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ABC12_RS18750	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ABC12_RS18755	COG0202	RNA polymerase activity
ABC12_RS18760	COG0203	ribosomal protein L17
ABC12_RS18765	COG0537	adenosine 5'-monophosphoramidase activity
ABC12_RS18770	COG1324	tolerance protein
ABC12_RS18775	COG4232	protein-disulfide reductase activity
ABC12_RS18790	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ABC12_RS18800	COG1333	cytochrome c biogenesis protein
ABC12_RS18805	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ABC12_RS18820	COG1965	Belongs to the frataxin family
ABC12_RS18830	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ABC12_RS18835	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ABC12_RS18840	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ABC12_RS18855	COG2814	Major facilitator Superfamily
ABC12_RS18860	COG0629	single-stranded DNA binding
ABC12_RS18900	COG0402	S-adenosylhomocysteine deaminase activity
ABC12_RS18910	COG0438	transferase activity, transferring glycosyl groups
ABC12_RS18930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ABC12_RS18955	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ABC12_RS18960	COG2186	Transcriptional regulator
ABC12_RS18980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ABC12_RS18985	COG1956	GAF domain-containing protein
ABC12_RS18990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ABC12_RS19005	COG1652	LysM domain
ABC12_RS19020	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ABC12_RS19035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ABC12_RS19065	COG3181	Tripartite tricarboxylate transporter family receptor
ABC12_RS19080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ABC12_RS19095	COG1024	Enoyl-CoA hydratase
ABC12_RS19110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ABC12_RS19115	COG1309	transcriptional regulator
ABC12_RS19120	COG2816	NAD+ diphosphatase activity
ABC12_RS19125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ABC12_RS19210	COG2814	Major facilitator Superfamily
ABC12_RS19215	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ABC12_RS19235	COG1999	signal sequence binding
ABC12_RS19240	COG0109	protoheme IX farnesyltransferase activity
ABC12_RS19280	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ABC12_RS19300	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ABC12_RS19305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ABC12_RS19315	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ABC12_RS19320	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ABC12_RS19330	COG0070	glutamate synthase
ABC12_RS19330	COG0069	glutamate synthase activity
ABC12_RS19330	COG0067	glutamate synthase
ABC12_RS19340	COG3047	cAMP biosynthetic process
ABC12_RS19350	COG1127	ABC transporter
ABC12_RS19355	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ABC12_RS19360	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ABC12_RS19365	COG2853	Lipoprotein
ABC12_RS19375	COG1131	(ABC) transporter
ABC12_RS19380	COG0842	Transport permease protein
ABC12_RS19390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ABC12_RS19395	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ABC12_RS19400	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ABC12_RS19405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ABC12_RS19410	COG0131	Imidazoleglycerol-phosphate dehydratase
ABC12_RS19415	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ABC12_RS19420	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ABC12_RS19425	COG0107	imidazoleglycerol-phosphate synthase activity
ABC12_RS19430	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ABC12_RS19435	COG0140	phosphoribosyl-ATP diphosphatase activity
ABC12_RS19440	COG0537	adenosine 5'-monophosphoramidase activity
ABC12_RS19445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ABC12_RS19450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ABC12_RS19465	COG3181	Tripartite tricarboxylate transporter family receptor
ABC12_RS19500	COG3702	type iv secretory pathway
ABC12_RS19505	COG3451	type IV secretory pathway VirB4
ABC12_RS19520	COG3736	Type IV secretory pathway, component VirB8
ABC12_RS19525	COG3504	Conjugal transfer protein
ABC12_RS19530	COG2948	multi-organism process
ABC12_RS19535	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
ABC12_RS19545	COG0697	spore germination
ABC12_RS19565	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ABC12_RS19570	COG0747	negative chemotaxis
ABC12_RS19575	COG0601	transmembrane transport
ABC12_RS19580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ABC12_RS19585	COG0444	Belongs to the ABC transporter superfamily
ABC12_RS19595	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ABC12_RS19605	COG0494	nUDIX hydrolase
ABC12_RS19645	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
ABC12_RS19650	COG0237	dephospho-CoA kinase activity
ABC12_RS19655	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ABC12_RS19670	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ABC12_RS19675	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ABC12_RS19685	COG0477	Major facilitator Superfamily
ABC12_RS19690	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ABC12_RS19705	COG1126	abc transporter atp-binding protein
ABC12_RS19710	COG0765	amino acid transport
ABC12_RS19715	COG4597	amino acid ABC transporter
ABC12_RS19720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ABC12_RS19725	COG2884	Cell division ATP-binding protein ftsE
ABC12_RS19730	COG2177	Part of the ABC transporter FtsEX involved in
ABC12_RS19735	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ABC12_RS19745	COG1194	a g-specific adenine glycosylase
ABC12_RS19755	COG2226	methyltransferase
ABC12_RS19765	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ABC12_RS19770	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ABC12_RS19785	COG1024	Enoyl-CoA hydratase
ABC12_RS19805	COG1024	Enoyl-CoA hydratase
ABC12_RS19810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ABC12_RS19815	COG3181	Tripartite tricarboxylate transporter family receptor
ABC12_RS19825	COG0753	catalase activity
ABC12_RS19830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ABC12_RS19835	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
ABC12_RS19845	COG2175	clavaminate synthase activity
ABC12_RS19850	COG1473	amidohydrolase
ABC12_RS19855	COG4608	Belongs to the ABC transporter superfamily
ABC12_RS19860	COG0444	Belongs to the ABC transporter superfamily
ABC12_RS19875	COG0747	negative chemotaxis
ABC12_RS19880	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ABC12_RS19915	COG0436	Aminotransferase
ABC12_RS19920	COG1278	Cold shock