locus-tag	class	description
WU42_RS00005	COG0445	tRNA wobble uridine modification
WU42_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
WU42_RS00015	COG1192	Involved in chromosome partitioning
WU42_RS00025	COG1475	DNA binding
WU42_RS00030	COG0252	asparaginase activity
WU42_RS00055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WU42_RS00065	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WU42_RS00075	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WU42_RS00080	COG0081	regulation of translation
WU42_RS00085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WU42_RS00090	COG0222	ribosome binding
WU42_RS00095	COG0085	RNA polymerase activity
WU42_RS00100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WU42_RS00140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU42_RS00165	COG1024	Enoyl-CoA hydratase
WU42_RS00185	COG0752	glycyl-tRNA synthetase alpha subunit
WU42_RS00190	COG0751	glycine-tRNA ligase activity
WU42_RS00195	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
WU42_RS00200	COG0204	Acyl-transferase
WU42_RS00215	COG0242	peptide deformylase activity
WU42_RS00250	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
WU42_RS00255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WU42_RS00260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WU42_RS00260	COG2813	Specifically methylates the guanine in position
WU42_RS00275	COG2223	nitrite transmembrane transporter activity
WU42_RS00285	COG1794	racemase activity, acting on amino acids and derivatives
WU42_RS00290	COG1126	abc transporter atp-binding protein
WU42_RS00295	COG0765	amino acid transport
WU42_RS00300	COG0765	amino acid transport
WU42_RS00305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WU42_RS00370	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
WU42_RS00400	COG0326	Molecular chaperone. Has ATPase activity
WU42_RS00405	COG0625	glutathione transferase activity
WU42_RS00420	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WU42_RS00425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WU42_RS00455	COG0438	transferase activity, transferring glycosyl groups
WU42_RS00460	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WU42_RS00465	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WU42_RS00495	COG0859	PFAM glycosyl transferase family 9
WU42_RS00510	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
WU42_RS00520	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WU42_RS00525	COG1127	ABC transporter
WU42_RS00545	COG1686	Belongs to the peptidase S11 family
WU42_RS00555	COG2921	Belongs to the UPF0250 family
WU42_RS00560	COG0321	lipoyl(octanoyl) transferase activity
WU42_RS00565	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WU42_RS00600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WU42_RS00610	COG0018	arginyl-trna synthetase
WU42_RS00630	COG0395	ABC-type sugar transport system, permease component
WU42_RS00635	COG1175	transmembrane transport
WU42_RS00640	COG1653	transport
WU42_RS00645	COG3842	ATPase activity
WU42_RS00650	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
WU42_RS00660	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
WU42_RS00680	COG1609	Transcriptional regulator
WU42_RS00690	COG0154	amidase activity
WU42_RS00695	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WU42_RS00705	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
WU42_RS00715	COG0583	DNA-binding transcription factor activity
WU42_RS00730	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
WU42_RS00735	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WU42_RS00750	COG1802	Transcriptional regulator
WU42_RS00765	COG1024	Enoyl-CoA hydratase
WU42_RS00775	COG3181	Tripartite tricarboxylate transporter family receptor
WU42_RS00790	COG1984	allophanate hydrolase subunit 2
WU42_RS00795	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
WU42_RS00805	COG0583	DNA-binding transcription factor activity
WU42_RS00810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WU42_RS00820	COG5002	protein histidine kinase activity
WU42_RS00830	COG5002	protein histidine kinase activity
WU42_RS00835	COG0745	RESPONSE REGULATOR receiver
WU42_RS00840	COG2226	methyltransferase
WU42_RS00855	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WU42_RS00875	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
WU42_RS00885	COG0513	Belongs to the DEAD box helicase family
WU42_RS00890	COG1280	lysine exporter protein (LysE YggA)
WU42_RS00895	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
WU42_RS00930	COG1054	Belongs to the UPF0176 family
WU42_RS00935	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WU42_RS00935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WU42_RS00945	COG0489	protein tyrosine kinase activity
WU42_RS00960	COG0717	Belongs to the dCTP deaminase family
WU42_RS00990	COG2081	HI0933 family
WU42_RS01000	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WU42_RS01010	COG0404	The glycine cleavage system catalyzes the degradation of glycine
WU42_RS01015	COG0509	glycine decarboxylation via glycine cleavage system
WU42_RS01020	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WU42_RS01020	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WU42_RS01060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WU42_RS01075	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
WU42_RS01085	COG1414	Transcriptional regulator
WU42_RS01090	COG1028	Short-chain dehydrogenase reductase Sdr
WU42_RS01095	COG2031	fatty acid transporter
WU42_RS01100	COG1250	3-hydroxyacyl-CoA dehydrogenase
WU42_RS01110	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
WU42_RS01115	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
WU42_RS01125	COG4257	antibiotic catabolic process
WU42_RS01150	COG1012	belongs to the aldehyde dehydrogenase family
WU42_RS01155	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
WU42_RS01160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WU42_RS01185	COG1028	Short-chain dehydrogenase reductase Sdr
WU42_RS01195	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WU42_RS01210	COG2188	Transcriptional regulator
WU42_RS01215	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
WU42_RS01240	COG0617	tRNA 3'-terminal CCA addition
WU42_RS01255	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WU42_RS01260	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WU42_RS01265	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WU42_RS01270	COG0586	Pfam SNARE associated Golgi protein
WU42_RS01275	COG0860	N-Acetylmuramoyl-L-alanine amidase
WU42_RS01280	COG0802	atpase or kinase
WU42_RS01285	COG0114	fumarate hydratase activity
WU42_RS01295	COG3181	Tripartite tricarboxylate transporter family receptor
WU42_RS01305	COG0405	Gamma-glutamyltransferase
WU42_RS01310	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU42_RS01320	COG1960	acyl-CoA dehydrogenase activity
WU42_RS01345	COG1294	oxidase, subunit
WU42_RS01355	COG4988	ABC transporter
WU42_RS01360	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
WU42_RS01365	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WU42_RS01380	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
WU42_RS01410	COG2969	positive regulation of protein catabolic process
WU42_RS01415	COG0625	glutathione transferase activity
WU42_RS01420	COG2857	Cytochrome c1
WU42_RS01425	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WU42_RS01430	COG0723	plastoquinol--plastocyanin reductase activity
WU42_RS01435	COG1970	mechanosensitive ion channel activity
WU42_RS01440	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
WU42_RS01455	COG2808	Putative FMN-binding domain
WU42_RS01460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WU42_RS01465	COG0747	negative chemotaxis
WU42_RS01470	COG0657	acetylesterase activity
WU42_RS01480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WU42_RS01485	COG2207	Transcriptional regulator
WU42_RS01490	COG0129	dihydroxy-acid dehydratase activity
WU42_RS01495	COG2814	Major facilitator Superfamily
WU42_RS01500	COG0583	DNA-binding transcription factor activity
WU42_RS01510	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
WU42_RS01580	COG1024	Enoyl-CoA hydratase
WU42_RS01585	COG1960	acyl-CoA dehydrogenase activity
WU42_RS01610	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
WU42_RS01615	COG0352	thiamine-phosphate diphosphorylase activity
WU42_RS01630	COG1678	Uncharacterized ACR, COG1678
WU42_RS01635	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WU42_RS01640	COG0540	Belongs to the ATCase OTCase family
WU42_RS01655	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WU42_RS01665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WU42_RS01700	COG1234	tRNA 3'-trailer cleavage
WU42_RS01720	COG3064	Membrane
WU42_RS01750	COG1683	Conserved Protein
WU42_RS01755	COG1120	ATPase activity
WU42_RS01760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WU42_RS01765	COG4558	Periplasmic binding protein
WU42_RS01770	COG3720	iron ion transport
WU42_RS01780	COG3712	iron ion homeostasis
WU42_RS01785	COG1595	DNA-templated transcription, initiation
WU42_RS01820	COG1802	Transcriptional regulator
WU42_RS01830	COG3069	C4-dicarboxylate transmembrane transporter activity
WU42_RS01840	COG1012	belongs to the aldehyde dehydrogenase family
WU42_RS01875	COG2860	membrane
WU42_RS01880	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
WU42_RS01885	COG0708	Exodeoxyribonuclease III
WU42_RS01890	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WU42_RS01895	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WU42_RS01900	COG0154	amidase activity
WU42_RS01905	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WU42_RS01910	COG1077	Cell shape determining protein MreB Mrl
WU42_RS01915	COG1792	Involved in formation and maintenance of cell shape
WU42_RS01925	COG0768	penicillin binding
WU42_RS01930	COG0772	Belongs to the SEDS family
WU42_RS01935	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
WU42_RS01940	COG0471	metal ion transport
WU42_RS01945	COG1309	transcriptional regulator
WU42_RS01955	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WU42_RS01970	COG2823	Periplasmic or secreted lipoprotein
WU42_RS01975	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
WU42_RS01990	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
WU42_RS02010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU42_RS02020	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU42_RS02040	COG0492	ferredoxin-NADP+ reductase activity
WU42_RS02050	COG3181	Tripartite tricarboxylate transporter family receptor
WU42_RS02055	COG1250	3-hydroxyacyl-CoA dehydrogenase
WU42_RS02055	COG1024	Enoyl-CoA hydratase
WU42_RS02060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU42_RS02065	COG0028	Belongs to the TPP enzyme family
WU42_RS02090	COG3181	Tripartite tricarboxylate transporter family receptor
WU42_RS02100	COG0697	spore germination
WU42_RS02130	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
WU42_RS02135	COG0463	Glycosyl transferase, family 2
WU42_RS02155	COG0786	glutamate:sodium symporter activity
WU42_RS02165	COG2031	fatty acid transporter
WU42_RS02180	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WU42_RS02185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WU42_RS02195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WU42_RS02210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WU42_RS02220	COG1285	pathogenesis
WU42_RS02225	COG1253	flavin adenine dinucleotide binding
WU42_RS02230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU42_RS02235	COG1024	Enoyl-CoA hydratase
WU42_RS02240	COG3181	Tripartite tricarboxylate transporter family receptor
WU42_RS02245	COG0583	DNA-binding transcription factor activity
WU42_RS02250	COG1960	acyl-CoA dehydrogenase activity
WU42_RS02260	COG0183	Belongs to the thiolase family
WU42_RS02280	COG0583	DNA-binding transcription factor activity
WU42_RS02285	COG1278	Cold shock
WU42_RS02295	COG1802	Transcriptional regulator
WU42_RS02300	COG1012	belongs to the aldehyde dehydrogenase family
WU42_RS02305	COG2031	fatty acid transporter
WU42_RS02310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WU42_RS02310	COG1017	nitric oxide dioxygenase activity
WU42_RS02315	COG0251	oxidation-reduction process
WU42_RS02335	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU42_RS02345	COG0583	DNA-binding transcription factor activity
WU42_RS02350	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU42_RS02360	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
WU42_RS02365	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
WU42_RS02370	COG0546	phosphoglycolate phosphatase activity
WU42_RS02380	COG1530	ribonuclease E activity
WU42_RS02395	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
WU42_RS02400	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
WU42_RS02405	COG0159	tryptophan synthase activity
WU42_RS02410	COG0133	tryptophan synthase activity
WU42_RS02420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WU42_RS02425	COG3228	Belongs to the MtfA family
WU42_RS02435	COG0251	oxidation-reduction process
WU42_RS02440	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
WU42_RS02445	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WU42_RS02460	COG2878	Part of a membrane complex involved in electron transport
WU42_RS02465	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WU42_RS02500	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WU42_RS02520	COG1268	BioY protein
WU42_RS02525	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
WU42_RS02530	COG1122	ATPase activity
WU42_RS02535	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WU42_RS02550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WU42_RS02555	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WU42_RS02565	COG1196	nuclear chromosome segregation
WU42_RS02570	COG0477	Major facilitator Superfamily
WU42_RS02575	COG1573	uracil-dna glycosylase
WU42_RS02580	COG1214	PFAM Peptidase M22, glycoprotease
WU42_RS02605	COG0450	alkyl hydroperoxide reductase
WU42_RS02610	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WU42_RS02620	COG2223	nitrite transmembrane transporter activity
WU42_RS02630	COG2186	Transcriptional regulator
WU42_RS02650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WU42_RS02660	COG0583	DNA-binding transcription factor activity
WU42_RS02670	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WU42_RS02675	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
WU42_RS02680	COG0137	argininosuccinate synthase activity
WU42_RS02685	COG3158	transport of potassium into the cell
WU42_RS02690	COG0642	Histidine kinase
WU42_RS02720	COG0776	regulation of translation
WU42_RS02725	COG3128	pkhd-type hydroxylase
WU42_RS02735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WU42_RS02740	COG0557	exoribonuclease II activity
WU42_RS02765	COG0679	Auxin Efflux Carrier
WU42_RS02770	COG2391	methyltransferase activity
WU42_RS02775	COG0069	glutamate synthase activity
WU42_RS02785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WU42_RS02795	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
WU42_RS02800	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WU42_RS02835	COG3706	GGDEF domain
WU42_RS02855	COG1053	succinate dehydrogenase
WU42_RS02860	COG0583	DNA-binding transcription factor activity
WU42_RS02870	COG1053	succinate dehydrogenase
WU42_RS02890	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WU42_RS02895	COG0459	protein refolding
WU42_RS02900	COG3468	outer membrane autotransporter barrel domain protein
WU42_RS02915	COG1252	NADH dehydrogenase
WU42_RS02920	COG0284	orotidine-5'-phosphate decarboxylase activity
WU42_RS02925	COG1058	Belongs to the CinA family
WU42_RS02925	COG1546	Belongs to the CinA family
WU42_RS02930	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WU42_RS02940	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WU42_RS02945	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
WU42_RS02980	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
WU42_RS02985	COG3639	organic phosphonate transmembrane transporter activity
WU42_RS02990	COG3639	organic phosphonate transmembrane transporter activity
WU42_RS03010	COG0742	ribosomal rna small subunit methyltransferase
WU42_RS03015	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WU42_RS03020	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WU42_RS03025	COG3135	benzoate transporter
WU42_RS03040	COG0640	Transcriptional regulator
WU42_RS03070	COG4172	Belongs to the ABC transporter superfamily
WU42_RS03075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WU42_RS03080	COG0601	transmembrane transport
WU42_RS03090	COG0281	malic enzyme
WU42_RS03090	COG0280	phosphate acetyltransferase
WU42_RS03150	COG0583	DNA-binding transcription factor activity
WU42_RS03160	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
WU42_RS03165	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
WU42_RS03170	COG0167	dihydroorotate dehydrogenase activity
WU42_RS03190	COG1414	Transcriptional regulator
WU42_RS03195	COG1058	Belongs to the CinA family
WU42_RS03195	COG1546	Belongs to the CinA family
WU42_RS03215	COG0513	Belongs to the DEAD box helicase family
WU42_RS03245	COG0429	hydrolase of the alpha beta-hydrolase fold
WU42_RS03250	COG4783	chaperone-mediated protein folding
WU42_RS03265	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
WU42_RS03290	COG0006	proline dipeptidase activity
WU42_RS03300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WU42_RS03320	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
WU42_RS03325	COG0632	four-way junction helicase activity
WU42_RS03340	COG2255	four-way junction helicase activity
WU42_RS03345	COG0514	ATP-dependent DNA helicase (RecQ)
WU42_RS03360	COG0288	reversible hydration of carbon dioxide
WU42_RS03365	COG0154	amidase activity
WU42_RS03375	COG4211	Belongs to the binding-protein-dependent transport system permease family
WU42_RS03405	COG1464	Belongs to the NlpA lipoprotein family
WU42_RS03550	COG1196	nuclear chromosome segregation
WU42_RS03620	COG2135	peptidase activity
WU42_RS03635	COG0494	nUDIX hydrolase
WU42_RS03640	COG0442	prolyl-tRNA aminoacylation
WU42_RS03645	COG0824	Thioesterase
WU42_RS03650	COG0811	peptide transport
WU42_RS03655	COG0848	biopolymer transport protein
WU42_RS03665	COG0823	Involved in the tonB-independent uptake of proteins
WU42_RS03680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WU42_RS03685	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
WU42_RS03720	COG0700	Nucleoside recognition
WU42_RS03725	COG0469	pyruvate kinase activity
WU42_RS03730	COG1929	Belongs to the glycerate kinase type-1 family
WU42_RS03735	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WU42_RS03740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WU42_RS03745	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
WU42_RS03755	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
WU42_RS03765	COG2154	pterin-4-alpha-carbinolamine dehydratase
WU42_RS03790	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WU42_RS03795	COG0154	amidase activity
WU42_RS03805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WU42_RS03810	COG0601	transmembrane transport
WU42_RS03815	COG0747	negative chemotaxis
WU42_RS03835	COG0019	diaminopimelate decarboxylase activity
WU42_RS03850	COG2353	YceI-like domain
WU42_RS03855	COG4774	siderophore transport
WU42_RS03860	COG3712	iron ion homeostasis
WU42_RS03900	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
WU42_RS03905	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WU42_RS03910	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WU42_RS03915	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WU42_RS03925	COG0142	geranyltranstransferase activity
WU42_RS03935	COG0583	DNA-binding transcription factor activity
WU42_RS03945	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
WU42_RS03950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WU42_RS03965	COG2994	toxin metabolic process
WU42_RS03975	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
WU42_RS03980	COG2274	protein secretion by the type I secretion system
WU42_RS03985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WU42_RS03990	COG1538	Outer membrane efflux protein
WU42_RS04005	COG0765	amino acid transport
WU42_RS04010	COG0765	amino acid transport
WU42_RS04015	COG1126	abc transporter atp-binding protein
WU42_RS04035	COG1028	Short-chain dehydrogenase reductase Sdr
WU42_RS04045	COG1802	Transcriptional regulator
WU42_RS04055	COG1802	Transcriptional regulator
WU42_RS04065	COG0318	PFAM AMP-dependent synthetase and ligase
WU42_RS04075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WU42_RS04095	COG0028	Belongs to the TPP enzyme family
WU42_RS04115	COG0308	aminopeptidase N
WU42_RS04120	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
WU42_RS04130	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
WU42_RS04135	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WU42_RS04140	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WU42_RS04145	COG0560	Phosphoserine phosphatase
WU42_RS04150	COG0583	DNA-binding transcription factor activity
WU42_RS04155	COG3181	Tripartite tricarboxylate transporter family receptor
WU42_RS04160	COG0028	Belongs to the TPP enzyme family
WU42_RS04175	COG4774	siderophore transport
WU42_RS04180	COG4774	siderophore transport
WU42_RS04190	COG1007	ATP synthesis coupled electron transport
WU42_RS04205	COG0713	ATP synthesis coupled electron transport
WU42_RS04215	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WU42_RS04220	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WU42_RS04225	COG1034	ATP synthesis coupled electron transport
WU42_RS04235	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
WU42_RS04240	COG0649	NAD binding
WU42_RS04245	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WU42_RS04250	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WU42_RS04255	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WU42_RS04260	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
WU42_RS04290	COG0671	phosphoesterase, PA-phosphatase related
WU42_RS04300	COG1597	lipid kinase activity
WU42_RS04305	COG0583	DNA-binding transcription factor activity
WU42_RS04310	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
WU42_RS04320	COG1733	regulation of RNA biosynthetic process
WU42_RS04325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WU42_RS04330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WU42_RS04345	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
WU42_RS04365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WU42_RS04385	COG3608	succinylglutamate desuccinylase aspartoacylase
WU42_RS04390	COG0626	cystathionine gamma-synthase activity
WU42_RS04395	COG0583	DNA-binding transcription factor activity
WU42_RS04430	COG3799	methylaspartate ammonia-lyase activity
WU42_RS04440	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
WU42_RS04450	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WU42_RS04455	COG0149	triose-phosphate isomerase activity
WU42_RS04475	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WU42_RS04490	COG1185	polyribonucleotide nucleotidyltransferase activity
WU42_RS04495	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WU42_RS04510	COG1183	phosphatidylcholine synthase activity
WU42_RS04515	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
WU42_RS04520	COG0440	acetolactate synthase activity
WU42_RS04525	COG0028	Belongs to the TPP enzyme family
WU42_RS04540	COG5265	(ABC) transporter
WU42_RS04545	COG0500	methyltransferase
WU42_RS04565	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
WU42_RS04585	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WU42_RS04595	COG0511	ligase activity, forming carbon-carbon bonds
WU42_RS04620	COG2188	Transcriptional regulator
WU42_RS04625	COG0439	Biotin carboxylase
WU42_RS04630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WU42_RS04675	COG5265	(ABC) transporter
WU42_RS04685	COG0667	Aldo Keto reductase
WU42_RS04700	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WU42_RS04740	COG0583	DNA-binding transcription factor activity
WU42_RS04765	COG2814	Major facilitator Superfamily
WU42_RS04775	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WU42_RS04790	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
WU42_RS04800	COG0287	Prephenate dehydrogenase
WU42_RS04805	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
WU42_RS04810	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
WU42_RS04830	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
WU42_RS04835	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
WU42_RS04840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WU42_RS04845	COG1596	polysaccharide export
WU42_RS04845	COG1555	photosystem II stabilization
WU42_RS04860	COG2951	lytic endotransglycosylase activity
WU42_RS04865	COG0123	including yeast histone deacetylase and acetoin utilization protein
WU42_RS04880	COG1960	acyl-CoA dehydrogenase activity
WU42_RS04885	COG0450	alkyl hydroperoxide reductase
WU42_RS04900	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
WU42_RS04905	COG4208	sulfate ABC transporter
WU42_RS04910	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
WU42_RS04940	COG0335	large ribosomal subunit rRNA binding
WU42_RS04955	COG0667	Aldo Keto reductase
WU42_RS04965	COG2814	Major facilitator Superfamily
WU42_RS04970	COG3161	chorismate lyase activity
WU42_RS04975	COG1187	pseudouridine synthase activity
WU42_RS04985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WU42_RS05005	COG1999	signal sequence binding
WU42_RS05010	COG0339	signal peptide processing
WU42_RS05015	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WU42_RS05020	COG4566	intracellular signal transduction
WU42_RS05030	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
WU42_RS05035	COG0508	dehydrogenase complex catalyzes the overall conversion of
WU42_RS05040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WU42_RS05045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WU42_RS05055	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WU42_RS05060	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
WU42_RS05065	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WU42_RS05070	COG0126	phosphoglycerate kinase activity
WU42_RS05075	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WU42_RS05080	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WU42_RS05095	COG0625	glutathione transferase activity
WU42_RS05130	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
WU42_RS05140	COG0521	Mo-molybdopterin cofactor biosynthetic process
WU42_RS05150	COG0739	heme binding
WU42_RS05160	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WU42_RS05195	COG0745	RESPONSE REGULATOR receiver
WU42_RS05210	COG0840	transmembrane signaling receptor activity
WU42_RS05220	COG2201	protein-glutamate methylesterase activity
WU42_RS05225	COG0745	RESPONSE REGULATOR receiver
WU42_RS05230	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
WU42_RS05255	COG0667	Aldo Keto reductase
WU42_RS05265	COG4535	Mg2 and Co2 transporter CorC
WU42_RS05270	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WU42_RS05275	COG1702	phosphate starvation-inducible protein PhoH
WU42_RS05280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WU42_RS05295	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WU42_RS05300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WU42_RS05305	COG1862	Preprotein translocase
WU42_RS05310	COG0343	queuine tRNA-ribosyltransferase activity
WU42_RS05315	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
WU42_RS05320	COG2027	D-alanyl-D-alanine carboxypeptidase
WU42_RS05325	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
WU42_RS05340	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WU42_RS05340	COG1648	precorrin-2 dehydrogenase activity
WU42_RS05365	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
WU42_RS05370	COG0741	lytic transglycosylase activity
WU42_RS05375	COG0436	Aminotransferase
WU42_RS05385	COG0280	phosphate acetyltransferase
WU42_RS05385	COG0281	malic enzyme
WU42_RS05395	COG2732	(Barnase) inhibitor
WU42_RS05410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
WU42_RS05435	COG0248	Ppx GppA phosphatase
WU42_RS05445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WU42_RS05455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WU42_RS05460	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
WU42_RS05465	COG1534	Rna-binding protein
WU42_RS05495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WU42_RS05510	COG1295	ribonuclease BN
WU42_RS05520	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
WU42_RS05525	COG0745	RESPONSE REGULATOR receiver
WU42_RS05530	COG2205	protein histidine kinase activity
WU42_RS05565	COG1022	Amp-dependent synthetase and ligase
WU42_RS05580	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
WU42_RS05585	COG1028	Short-chain dehydrogenase reductase Sdr
WU42_RS05595	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WU42_RS05610	COG1136	(ABC) transporter
WU42_RS05615	COG0084	hydrolase, TatD family'
WU42_RS05645	COG0658	competence protein
WU42_RS05645	COG2333	competence protein COMEC
WU42_RS05655	COG0613	PHP domain protein
WU42_RS05670	COG3539	Fimbrial protein
WU42_RS05675	COG0281	malic enzyme
WU42_RS05675	COG0280	phosphate acetyltransferase
WU42_RS05685	COG1522	sequence-specific DNA binding
WU42_RS05695	COG0567	Dehydrogenase, E1 component
WU42_RS05700	COG0508	dehydrogenase complex catalyzes the overall conversion of
WU42_RS05705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WU42_RS05710	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
WU42_RS05715	COG1028	Short-chain dehydrogenase reductase Sdr
WU42_RS05720	COG0583	DNA-binding transcription factor activity
WU42_RS05730	COG3181	Tripartite tricarboxylate transporter family receptor
WU42_RS05755	COG0180	Tryptophanyl-tRNA synthetase
WU42_RS05760	COG2183	response to ionizing radiation
WU42_RS05765	COG1199	ATP-dependent helicase activity
WU42_RS05775	COG0564	pseudouridine synthase activity
WU42_RS05785	COG3243	poly(R)-hydroxyalkanoic acid synthase
WU42_RS05790	COG1028	Short-chain dehydrogenase reductase Sdr
WU42_RS05795	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
WU42_RS05810	COG0672	)-iron permease
WU42_RS05850	COG0583	DNA-binding transcription factor activity
WU42_RS05860	COG2814	Major facilitator Superfamily
WU42_RS05875	COG1619	proteins homologs of microcin C7 resistance protein MccF
WU42_RS05890	COG2084	Dehydrogenase
WU42_RS05895	COG3181	Tripartite tricarboxylate transporter family receptor
WU42_RS05920	COG2988	succinylglutamate desuccinylase activity
WU42_RS05950	COG0765	amino acid transport
WU42_RS05955	COG0765	amino acid transport
WU42_RS05960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WU42_RS05995	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WU42_RS06000	COG1595	DNA-templated transcription, initiation
WU42_RS06010	COG3530	Putative quorum-sensing-regulated virulence factor
WU42_RS06015	COG0494	nUDIX hydrolase
WU42_RS06030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WU42_RS06035	COG0542	response to heat
WU42_RS06050	COG3468	outer membrane autotransporter barrel domain protein
WU42_RS06055	COG3468	outer membrane autotransporter barrel domain protein
WU42_RS06065	COG5441	Belongs to the UPF0261 family
WU42_RS06070	COG5564	TIM-barrel signal transduction protein
WU42_RS06085	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
WU42_RS06100	COG1477	protein flavinylation
WU42_RS06120	COG1131	(ABC) transporter
WU42_RS06125	COG0842	Transport permease protein
WU42_RS06135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
WU42_RS06140	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
WU42_RS06140	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
WU42_RS06145	COG1562	ergosterol biosynthetic process
WU42_RS06150	COG1562	ergosterol biosynthetic process
WU42_RS06155	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WU42_RS06160	COG1028	Short-chain dehydrogenase reductase Sdr
WU42_RS06180	COG2304	oxidoreductase activity
WU42_RS06200	COG0534	Mate efflux family protein
WU42_RS06210	COG0254	rRNA binding
WU42_RS06215	COG3483	tryptophan 2,3-dioxygenase activity
WU42_RS06220	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
WU42_RS06225	COG2003	Belongs to the UPF0758 family
WU42_RS06230	COG1047	Peptidyl-prolyl cis-trans
WU42_RS06235	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
WU42_RS06240	COG0625	glutathione transferase activity
WU42_RS06260	COG0523	cobalamin synthesis protein
WU42_RS06270	COG0583	DNA-binding transcription factor activity
WU42_RS06280	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
WU42_RS06285	COG1187	pseudouridine synthase activity
WU42_RS06290	COG0779	Required for maturation of 30S ribosomal subunits
WU42_RS06295	COG0195	Participates in both transcription termination and antitermination
WU42_RS06295	COG2251	uridine kinase activity
WU42_RS06300	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WU42_RS06305	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WU42_RS06310	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WU42_RS06330	COG1611	Belongs to the LOG family
WU42_RS06345	COG0412	Dienelactone hydrolase
WU42_RS06350	COG1283	sodium-dependent phosphate transmembrane transporter activity
WU42_RS06355	COG1760	l-serine dehydratase
WU42_RS06360	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
WU42_RS06365	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
WU42_RS06375	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
WU42_RS06400	COG2311	Membrane
WU42_RS06410	COG0697	spore germination
WU42_RS06425	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
WU42_RS06440	COG0559	Belongs to the binding-protein-dependent transport system permease family
WU42_RS06455	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
WU42_RS06465	COG1653	transport
WU42_RS06470	COG1175	transmembrane transport
WU42_RS06475	COG0395	ABC-type sugar transport system, permease component
WU42_RS06480	COG3842	ATPase activity
WU42_RS06505	COG2363	Small membrane protein
WU42_RS06520	COG1464	Belongs to the NlpA lipoprotein family
WU42_RS06530	COG0688	phosphatidylethanolamine metabolic process
WU42_RS06555	COG0625	glutathione transferase activity
WU42_RS06560	COG0386	Belongs to the glutathione peroxidase family
WU42_RS06580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU42_RS06610	COG2259	Doxx family
WU42_RS06625	COG0667	Aldo Keto reductase
WU42_RS06655	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
WU42_RS06675	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
WU42_RS06685	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
WU42_RS06730	COG0392	lysyltransferase activity
WU42_RS06745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WU42_RS06750	COG3568	Endonuclease Exonuclease Phosphatase
WU42_RS06760	COG1695	Transcriptional regulator
WU42_RS06780	COG0583	DNA-binding transcription factor activity
WU42_RS06795	COG1802	Transcriptional regulator
WU42_RS06805	COG3181	Tripartite tricarboxylate transporter family receptor
WU42_RS06815	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU42_RS06830	COG0066	3-isopropylmalate dehydratase activity
WU42_RS06840	COG3181	Tripartite tricarboxylate transporter family receptor
WU42_RS06845	COG4948	Mandelate Racemase Muconate Lactonizing
WU42_RS06860	COG1126	abc transporter atp-binding protein
WU42_RS06865	COG0765	amino acid transport
WU42_RS06870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WU42_RS06890	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
WU42_RS06915	COG1815	bacterial-type flagellum-dependent cell motility
WU42_RS06920	COG1558	bacterial-type flagellum-dependent cell motility
WU42_RS06930	COG1749	Flagellar hook protein flgE
WU42_RS06945	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
WU42_RS06950	COG1706	bacterial-type flagellum-dependent cell motility
WU42_RS06960	COG1256	bacterial-type flagellum assembly
WU42_RS06970	COG0840	transmembrane signaling receptor activity
WU42_RS06975	COG0840	transmembrane signaling receptor activity
WU42_RS06980	COG0840	transmembrane signaling receptor activity
WU42_RS07000	COG1338	Plays a role in the flagellum-specific transport system
WU42_RS07020	COG1580	Controls the rotational direction of flagella during chemotaxis
WU42_RS07045	COG1157	protein secretion by the type III secretion system
WU42_RS07055	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WU42_RS07065	COG1677	Flagellar hook-basal body complex protein FliE
WU42_RS07075	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
WU42_RS07110	COG0285	dihydrofolate synthase activity
WU42_RS07140	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
WU42_RS07145	COG0024	Methionine aminopeptidase
WU42_RS07150	COG0052	Belongs to the universal ribosomal protein uS2 family
WU42_RS07155	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WU42_RS07160	COG0528	UMP kinase activity
WU42_RS07165	COG0233	cytoplasmic translational termination
WU42_RS07170	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WU42_RS07180	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
WU42_RS07185	COG0750	zinc metalloprotease
WU42_RS07190	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WU42_RS07195	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
WU42_RS07200	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WU42_RS07205	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WU42_RS07215	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WU42_RS07220	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WU42_RS07225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WU42_RS07230	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
WU42_RS07240	COG0519	Catalyzes the synthesis of GMP from XMP
WU42_RS07240	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WU42_RS07255	COG0330	HflC and HflK could
WU42_RS07260	COG3706	GGDEF domain
WU42_RS07265	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WU42_RS07275	COG2867	negative regulation of translational initiation
WU42_RS07285	COG1960	acyl-CoA dehydrogenase activity
WU42_RS07290	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
WU42_RS07320	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WU42_RS07325	COG0505	Belongs to the CarA family
WU42_RS07330	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WU42_RS07340	COG0406	alpha-ribazole phosphatase activity
WU42_RS07350	COG3842	ATPase activity
WU42_RS07370	COG5001	Diguanylate cyclase
WU42_RS07375	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
WU42_RS07385	COG1763	Mo-molybdopterin cofactor biosynthetic process
WU42_RS07390	COG0303	'Molybdopterin
WU42_RS07395	COG0746	molybdenum cofactor guanylyltransferase activity
WU42_RS07400	COG0489	protein tyrosine kinase activity
WU42_RS07430	COG3383	formate dehydrogenase (NAD+) activity
WU42_RS07430	COG0243	molybdopterin cofactor binding
WU42_RS07435	COG0437	4 iron, 4 sulfur cluster binding
WU42_RS07465	COG1122	ATPase activity
WU42_RS07475	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
WU42_RS07480	COG0066	3-isopropylmalate dehydratase activity
WU42_RS07485	COG0473	3-isopropylmalate dehydrogenase activity
WU42_RS07490	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WU42_RS07500	COG0101	tRNA pseudouridine synthase activity
WU42_RS07505	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
WU42_RS07520	COG0135	phosphoribosylanthranilate isomerase activity
WU42_RS07535	COG3022	response to hydroperoxide
WU42_RS07545	COG1289	transmembrane transporter activity
WU42_RS07550	COG3023	N-Acetylmuramoyl-L-alanine amidase
WU42_RS07560	COG0424	maF-like protein
WU42_RS07565	COG1399	metal-binding, possibly nucleic acid-binding protein
WU42_RS07570	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WU42_RS07575	COG0416	fatty acid biosynthetic process
WU42_RS07580	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WU42_RS07595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WU42_RS07600	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WU42_RS07625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WU42_RS07630	COG0481	GTPase activity
WU42_RS07635	COG0681	Belongs to the peptidase S26 family
WU42_RS07640	COG0571	ribonuclease III activity
WU42_RS07645	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WU42_RS07650	COG1381	Involved in DNA repair and RecF pathway recombination
WU42_RS07660	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
WU42_RS07670	COG3181	Tripartite tricarboxylate transporter family receptor
WU42_RS07675	COG0670	Belongs to the BI1 family
WU42_RS07690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WU42_RS07700	COG0583	DNA-binding transcription factor activity
WU42_RS07715	COG0583	DNA-binding transcription factor activity
WU42_RS07730	COG0791	NLP P60 protein
WU42_RS07735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WU42_RS07740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WU42_RS07745	COG3193	protein, possibly involved in utilization of glycolate and propanediol
WU42_RS07755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WU42_RS07760	COG0697	spore germination
WU42_RS07765	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
WU42_RS07780	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WU42_RS07810	COG1446	asparaginase
WU42_RS07815	COG4172	Belongs to the ABC transporter superfamily
WU42_RS07820	COG0747	negative chemotaxis
WU42_RS07830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WU42_RS07855	COG0504	CTP synthase activity
WU42_RS07860	COG2877	3-deoxy-8-phosphooctulonate synthase activity
WU42_RS07870	COG0148	phosphopyruvate hydratase activity
WU42_RS07875	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
WU42_RS07905	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
WU42_RS07915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WU42_RS07940	COG1981	membrane
WU42_RS07970	COG0039	L-malate dehydrogenase activity
WU42_RS07975	COG2188	Transcriptional regulator
WU42_RS07980	COG2009	succinate dehydrogenase
WU42_RS07985	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
WU42_RS07990	COG1053	succinate dehydrogenase
WU42_RS07995	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WU42_RS08000	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
WU42_RS08005	COG0372	Belongs to the citrate synthase family
WU42_RS08025	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
WU42_RS08025	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
WU42_RS08035	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
WU42_RS08040	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
WU42_RS08055	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
WU42_RS08060	COG3842	ATPase activity
WU42_RS08065	COG1176	ABC-type spermidine putrescine transport system, permease component I
WU42_RS08070	COG1177	transmembrane transport
WU42_RS08095	COG1960	acyl-CoA dehydrogenase activity
WU42_RS08100	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
WU42_RS08105	COG0704	Plays a role in the regulation of phosphate uptake
WU42_RS08115	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
WU42_RS08120	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
WU42_RS08120	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WU42_RS08125	COG1643	Atp-dependent helicase
WU42_RS08140	COG0438	transferase activity, transferring glycosyl groups
WU42_RS08145	COG0726	polysaccharide deacetylase
WU42_RS08150	COG0463	Glycosyl transferase, family 2
WU42_RS08155	COG0438	transferase activity, transferring glycosyl groups
WU42_RS08160	COG2194	sulfuric ester hydrolase activity
WU42_RS08185	COG0859	PFAM glycosyl transferase family 9
WU42_RS08190	COG1132	(ABC) transporter
WU42_RS08205	COG0077	Prephenate dehydratase
WU42_RS08210	COG1530	ribonuclease E activity
WU42_RS08250	COG3468	outer membrane autotransporter barrel domain protein
WU42_RS08255	COG0424	maF-like protein
WU42_RS08260	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
WU42_RS08265	COG0799	negative regulation of ribosome biogenesis
WU42_RS08270	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
WU42_RS08275	COG0408	coproporphyrinogen oxidase activity
WU42_RS08280	COG0151	Belongs to the GarS family
WU42_RS08285	COG0217	transcriptional regulatory protein
WU42_RS08290	COG0433	COG0433 Predicted ATPase
WU42_RS08295	COG1115	amino acid carrier protein
WU42_RS08300	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WU42_RS08310	COG1012	belongs to the aldehyde dehydrogenase family
WU42_RS08335	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
WU42_RS08350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WU42_RS08360	COG0747	negative chemotaxis
WU42_RS08370	COG0473	3-isopropylmalate dehydrogenase activity
WU42_RS08375	COG2814	Major facilitator Superfamily
WU42_RS08380	COG1566	PFAM secretion protein HlyD family protein
WU42_RS08390	COG1846	Transcriptional regulator
WU42_RS08400	COG0697	spore germination
WU42_RS08410	COG0501	Belongs to the peptidase M48B family
WU42_RS08430	COG0583	DNA-binding transcription factor activity
WU42_RS08435	COG3842	ATPase activity
WU42_RS08440	COG1178	ABC-type Fe3 transport system permease component
WU42_RS08445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WU42_RS08450	COG1840	ABC-type Fe3 transport system, periplasmic component
WU42_RS08455	COG0492	ferredoxin-NADP+ reductase activity
WU42_RS08475	COG2233	PERMEase
WU42_RS08480	COG0840	transmembrane signaling receptor activity
WU42_RS08485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WU42_RS08515	COG4789	Type iii secretion
WU42_RS08580	COG4669	(LipO)protein
WU42_RS08615	COG4790	Type iii secretion
WU42_RS08620	COG4794	Type iii secretion
WU42_RS08625	COG4791	protein targeting
WU42_RS08630	COG4792	protein secretion
WU42_RS08645	COG1595	DNA-templated transcription, initiation
WU42_RS08670	COG2208	phosphoserine phosphatase activity
WU42_RS08670	COG2770	Histidine kinase
WU42_RS08680	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WU42_RS08685	COG2172	sigma factor antagonist activity
WU42_RS08690	COG1366	Belongs to the anti-sigma-factor antagonist family
WU42_RS08695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WU42_RS08730	COG2358	TRAP transporter, solute receptor (TAXI family
WU42_RS08735	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WU42_RS08765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WU42_RS08775	COG2252	PERMEase
WU42_RS08780	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WU42_RS08790	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
WU42_RS08795	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WU42_RS08825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WU42_RS08830	COG0789	Transcriptional regulator
WU42_RS08840	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
WU42_RS08840	COG0678	peroxiredoxin activity
WU42_RS08850	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
WU42_RS08855	COG0584	glycerophosphoryl diester phosphodiesterase
WU42_RS08860	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WU42_RS08870	COG4181	ATPase activity
WU42_RS08880	COG2823	Periplasmic or secreted lipoprotein
WU42_RS08890	COG3237	CsbD-like
WU42_RS08895	COG1181	Belongs to the D-alanine--D-alanine ligase family
WU42_RS08895	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WU42_RS08900	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WU42_RS08900	COG0189	ligase activity
WU42_RS08920	COG2833	Protein of unknown function (DUF455)
WU42_RS08925	COG2951	lytic endotransglycosylase activity
WU42_RS08945	COG1522	sequence-specific DNA binding
WU42_RS08955	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WU42_RS08960	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WU42_RS08965	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WU42_RS08970	COG0196	riboflavin kinase activity
WU42_RS08975	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WU42_RS08995	COG0210	DNA helicase
WU42_RS09000	COG4771	TonB-dependent receptor
WU42_RS09005	COG0488	(ABC) transporter
WU42_RS09010	COG2890	protein-(glutamine-N5) methyltransferase activity
WU42_RS09015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WU42_RS09020	COG2171	N-acyltransferase activity
WU42_RS09055	COG1278	Cold shock
WU42_RS09075	COG0544	peptidyl-prolyl cis-trans isomerase activity
WU42_RS09080	COG0740	serine-type endopeptidase activity
WU42_RS09085	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WU42_RS09090	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WU42_RS09095	COG0583	DNA-binding transcription factor activity
WU42_RS09100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU42_RS09115	COG1024	Enoyl-CoA hydratase
WU42_RS09125	COG0183	Belongs to the thiolase family
WU42_RS09130	COG1028	Short-chain dehydrogenase reductase Sdr
WU42_RS09135	COG1960	acyl-CoA dehydrogenase activity
WU42_RS09150	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
WU42_RS09180	COG3468	outer membrane autotransporter barrel domain protein
WU42_RS09185	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WU42_RS09195	COG0556	nucleotide-excision repair
WU42_RS09200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
WU42_RS09210	COG1104	cysteine desulfurase activity
WU42_RS09215	COG0822	iron-sulfur transferase activity
WU42_RS09220	COG0316	Belongs to the HesB IscA family
WU42_RS09225	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
WU42_RS09230	COG0443	Heat shock 70 kDa protein
WU42_RS09235	COG0633	Ferredoxin
WU42_RS09255	COG1024	Enoyl-CoA hydratase
WU42_RS09270	COG3395	kinase activity
WU42_RS09275	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
WU42_RS09290	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
WU42_RS09300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WU42_RS09325	COG0747	negative chemotaxis
WU42_RS09330	COG0601	transmembrane transport
WU42_RS09335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WU42_RS09340	COG4172	Belongs to the ABC transporter superfamily
WU42_RS09345	COG0154	amidase activity
WU42_RS09390	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WU42_RS09395	COG0425	Belongs to the sulfur carrier protein TusA family
WU42_RS09405	COG0228	four-way junction DNA binding
WU42_RS09410	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WU42_RS09415	COG0336	Belongs to the RNA methyltransferase TrmD family
WU42_RS09420	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WU42_RS09440	COG0642	Histidine kinase
WU42_RS09455	COG0525	valine-tRNA ligase activity
WU42_RS09460	COG0105	UTP biosynthetic process
WU42_RS09465	COG0820	rRNA (adenine-C2-)-methyltransferase activity
WU42_RS09475	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
WU42_RS09480	COG0124	histidyl-tRNA synthetase
WU42_RS09485	COG2976	Protein conserved in bacteria
WU42_RS09490	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WU42_RS09495	COG1160	GTP binding
WU42_RS09500	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
WU42_RS09505	COG1923	regulation of RNA biosynthetic process
WU42_RS09510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WU42_RS09515	COG0330	HflC and HflK could
WU42_RS09520	COG0330	HflC and HflK could
WU42_RS09525	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
WU42_RS09530	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
WU42_RS09535	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
WU42_RS09540	COG0828	Belongs to the bacterial ribosomal protein bS21 family
WU42_RS09550	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WU42_RS09580	COG0628	permease
WU42_RS09585	COG0842	Transport permease protein
WU42_RS09590	COG1131	(ABC) transporter
WU42_RS09660	COG0156	8-amino-7-oxononanoate synthase activity
WU42_RS09670	COG4106	trans-aconitate 2-methyltransferase activity
WU42_RS09670	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
WU42_RS09675	COG1380	Effector of murein hydrolase LrgA
WU42_RS09695	COG3284	Transcriptional regulator
WU42_RS09700	COG1012	belongs to the aldehyde dehydrogenase family
WU42_RS09715	COG2733	membrane
WU42_RS09720	COG0583	DNA-binding transcription factor activity
WU42_RS09725	COG0384	phenazine biosynthesis protein PhzF
WU42_RS09730	COG5507	3-demethylubiquinone-9 3-methyltransferase
WU42_RS09735	COG2169	Transcriptional regulator
WU42_RS09765	COG0659	secondary active sulfate transmembrane transporter activity
WU42_RS09790	COG1132	(ABC) transporter
WU42_RS09835	COG2207	Transcriptional regulator
WU42_RS09970	COG2346	COG2346, Truncated hemoglobins
WU42_RS10015	COG0183	Belongs to the thiolase family
WU42_RS10030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU42_RS10035	COG0633	Ferredoxin
WU42_RS10045	COG1024	Enoyl-CoA hydratase
WU42_RS10055	COG4638	Rieske (2fe-2S)
WU42_RS10065	COG0559	Belongs to the binding-protein-dependent transport system permease family
WU42_RS10085	COG2224	Isocitrate lyase
WU42_RS10090	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WU42_RS10090	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WU42_RS10105	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WU42_RS10110	COG0322	excinuclease ABC activity
WU42_RS10115	COG1472	Belongs to the glycosyl hydrolase 3 family
WU42_RS10120	COG0736	holo-[acyl-carrier-protein] synthase activity
WU42_RS10125	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
WU42_RS10135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WU42_RS10140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WU42_RS10165	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
WU42_RS10180	COG2032	superoxide dismutase activity
WU42_RS10195	COG1024	Enoyl-CoA hydratase
WU42_RS10205	COG1802	Transcriptional regulator
WU42_RS10215	COG0183	Belongs to the thiolase family
WU42_RS10220	COG1942	4-Oxalocrotonate Tautomerase
WU42_RS10230	COG4176	ABC-type proline glycine betaine transport system permease component
WU42_RS10245	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WU42_RS10250	COG2814	Major facilitator Superfamily
WU42_RS10255	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WU42_RS10260	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WU42_RS10290	COG2814	Major facilitator Superfamily
WU42_RS10295	COG0495	leucyl-tRNA aminoacylation
WU42_RS10310	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
WU42_RS10320	COG0154	amidase activity
WU42_RS10325	COG1250	3-hydroxyacyl-CoA dehydrogenase
WU42_RS10380	COG0427	acetyl-CoA hydrolase
WU42_RS10385	COG0583	DNA-binding transcription factor activity
WU42_RS10405	COG0730	response to heat
WU42_RS10410	COG0697	spore germination
WU42_RS10445	COG2885	chlorophyll binding
WU42_RS10470	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
WU42_RS10475	COG3384	dioxygenase
WU42_RS10490	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WU42_RS10495	COG3474	cytochrome
WU42_RS10505	COG1595	DNA-templated transcription, initiation
WU42_RS10520	COG2204	response regulator
WU42_RS10560	COG4964	Belongs to the GSP D family
WU42_RS10610	COG1846	Transcriptional regulator
WU42_RS10615	COG4172	Belongs to the ABC transporter superfamily
WU42_RS10620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WU42_RS10625	COG0601	transmembrane transport
WU42_RS10630	COG0747	negative chemotaxis
WU42_RS10640	COG0598	Magnesium transport protein CorA
WU42_RS10645	COG0210	DNA helicase
WU42_RS10660	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
WU42_RS10665	COG1012	belongs to the aldehyde dehydrogenase family
WU42_RS10670	COG0483	inositol monophosphate 1-phosphatase activity
WU42_RS10675	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
WU42_RS10685	COG1045	serine acetyltransferase
WU42_RS10690	COG0166	Belongs to the GPI family
WU42_RS10705	COG2197	response regulator
WU42_RS10710	COG1846	Transcriptional regulator
WU42_RS10730	COG1649	PFAM Uncharacterised BCR, COG1649
WU42_RS10730	COG0726	polysaccharide deacetylase
WU42_RS10735	COG1215	transferase activity, transferring glycosyl groups
WU42_RS10745	COG1902	pentaerythritol trinitrate reductase activity
WU42_RS10770	COG0251	oxidation-reduction process
WU42_RS10780	COG1832	CoA-binding protein
WU42_RS10785	COG1414	Transcriptional regulator
WU42_RS10790	COG1902	pentaerythritol trinitrate reductase activity
WU42_RS10790	COG0446	pyridine nucleotide-disulphide oxidoreductase
WU42_RS10800	COG3842	ATPase activity
WU42_RS10830	COG0583	DNA-binding transcription factor activity
WU42_RS10840	COG1028	Short-chain dehydrogenase reductase Sdr
WU42_RS10845	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
WU42_RS10850	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WU42_RS10865	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
WU42_RS10865	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
WU42_RS10870	COG1250	3-hydroxyacyl-CoA dehydrogenase
WU42_RS10895	COG0527	aspartate kinase activity
WU42_RS10900	COG0037	tRNA processing
WU42_RS10910	COG0825	malonyl-CoA metabolic process
WU42_RS10920	COG0215	cysteine-tRNA ligase activity
WU42_RS10935	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WU42_RS10940	COG1968	undecaprenyl-diphosphatase activity
WU42_RS10945	COG1253	flavin adenine dinucleotide binding
WU42_RS10950	COG0483	inositol monophosphate 1-phosphatase activity
WU42_RS10970	COG0668	transmembrane transport
WU42_RS10995	COG0583	DNA-binding transcription factor activity
WU42_RS11020	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
WU42_RS11035	COG2831	hemolysin activation secretion protein
WU42_RS11040	COG3539	Fimbrial protein
WU42_RS11045	COG3188	usher protein
WU42_RS11050	COG3121	Chaperone
WU42_RS11060	COG3064	Membrane
WU42_RS11060	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
WU42_RS11060	COG3210	domain, Protein
WU42_RS11065	COG2197	response regulator
WU42_RS11070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WU42_RS11070	COG2205	protein histidine kinase activity
WU42_RS11080	COG4336	lyase activity
WU42_RS11105	COG2010	Cytochrome c
WU42_RS11110	COG3189	MarR family transcriptional regulator
WU42_RS11125	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
WU42_RS11135	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
WU42_RS11135	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
WU42_RS11145	COG0028	Belongs to the TPP enzyme family
WU42_RS11155	COG1012	belongs to the aldehyde dehydrogenase family
WU42_RS11160	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
WU42_RS11165	COG0010	Belongs to the arginase family
WU42_RS11170	COG1126	abc transporter atp-binding protein
WU42_RS11180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WU42_RS11195	COG0084	hydrolase, TatD family'
WU42_RS11200	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WU42_RS11205	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WU42_RS11210	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WU42_RS11225	COG0587	DNA-directed DNA polymerase activity
WU42_RS11235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WU42_RS11240	COG1959	2 iron, 2 sulfur cluster binding
WU42_RS11245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WU42_RS11245	COG1017	nitric oxide dioxygenase activity
WU42_RS11280	COG0488	(ABC) transporter
WU42_RS11285	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
WU42_RS11300	COG1024	Enoyl-CoA hydratase
WU42_RS11305	COG1619	proteins homologs of microcin C7 resistance protein MccF
WU42_RS11310	COG0590	tRNA wobble adenosine to inosine editing
WU42_RS11335	COG2212	antiporter activity
WU42_RS11340	COG1863	multisubunit Na H antiporter MnhE subunit
WU42_RS11345	COG0651	ATP synthesis coupled electron transport
WU42_RS11350	COG1006	Multisubunit Na H antiporter MnhC subunit
WU42_RS11355	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WU42_RS11355	COG2111	Na H antiporter
WU42_RS11360	COG3181	Tripartite tricarboxylate transporter family receptor
WU42_RS11375	COG0583	DNA-binding transcription factor activity
WU42_RS11380	COG1028	Short-chain dehydrogenase reductase Sdr
WU42_RS11410	COG0431	NADPH-dependent FMN reductase
WU42_RS11455	COG1028	Short-chain dehydrogenase reductase Sdr
WU42_RS11460	COG0179	Fumarylacetoacetate (FAA) hydrolase
WU42_RS11490	COG0625	glutathione transferase activity
WU42_RS11495	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
WU42_RS11500	COG2944	sequence-specific DNA binding
WU42_RS11510	COG2197	response regulator
WU42_RS11535	COG3119	arylsulfatase activity
WU42_RS11570	COG0714	Associated with various cellular activities
WU42_RS11590	COG1028	Short-chain dehydrogenase reductase Sdr
WU42_RS11595	COG0861	Integral membrane protein TerC family
WU42_RS11640	COG0300	oxidoreductase activity
WU42_RS11665	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
WU42_RS11680	COG0438	transferase activity, transferring glycosyl groups
WU42_RS11700	COG0463	Glycosyl transferase, family 2
WU42_RS11715	COG0783	Belongs to the Dps family
WU42_RS11730	COG0583	DNA-binding transcription factor activity
WU42_RS11735	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WU42_RS11750	COG0656	L-ascorbic acid biosynthetic process
WU42_RS11760	COG0583	DNA-binding transcription factor activity
WU42_RS11770	COG1840	ABC-type Fe3 transport system, periplasmic component
WU42_RS11775	COG1178	ABC-type Fe3 transport system permease component
WU42_RS11780	COG3842	ATPase activity
WU42_RS11790	COG1741	Belongs to the pirin family
WU42_RS11795	COG1741	Belongs to the pirin family
WU42_RS11800	COG0583	DNA-binding transcription factor activity
WU42_RS11805	COG2204	response regulator
WU42_RS11815	COG0174	glutamine synthetase
WU42_RS11820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WU42_RS11830	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WU42_RS11835	COG2200	EAL domain
WU42_RS11835	COG2199	diguanylate cyclase activity
WU42_RS11840	COG0840	transmembrane signaling receptor activity
WU42_RS11855	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
WU42_RS11860	COG1561	YicC-like family, N-terminal region
WU42_RS11880	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WU42_RS11885	COG0791	NLP P60 protein
WU42_RS11890	COG1028	Short-chain dehydrogenase reductase Sdr
WU42_RS11895	COG2863	cytochrome
WU42_RS11900	COG3258	Cytochrome c
WU42_RS11905	COG0194	GDP metabolic process
WU42_RS11910	COG1758	RNA polymerase activity
WU42_RS11915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WU42_RS11920	COG1126	abc transporter atp-binding protein
WU42_RS11925	COG0765	amino acid transport
WU42_RS11930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WU42_RS11950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WU42_RS11955	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
WU42_RS11960	COG3539	Fimbrial protein
WU42_RS11965	COG2850	peptidyl-arginine hydroxylation
WU42_RS11970	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WU42_RS11975	COG3360	Dodecin
WU42_RS12020	COG0009	L-threonylcarbamoyladenylate synthase
WU42_RS12025	COG2321	neutral zinc metallopeptidase
WU42_RS12045	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WU42_RS12050	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WU42_RS12055	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WU42_RS12070	COG1074	ATP-dependent DNA helicase activity
WU42_RS12080	COG2814	Major facilitator Superfamily
WU42_RS12090	COG1686	Belongs to the peptidase S11 family
WU42_RS12105	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
WU42_RS12110	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
WU42_RS12115	COG4974	Belongs to the 'phage' integrase family
WU42_RS12120	COG0583	DNA-binding transcription factor activity
WU42_RS12125	COG0028	Belongs to the TPP enzyme family
WU42_RS12140	COG0028	Belongs to the TPP enzyme family
WU42_RS12145	COG1126	abc transporter atp-binding protein
WU42_RS12150	COG0765	amino acid transport
WU42_RS12165	COG1414	Transcriptional regulator
WU42_RS12170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WU42_RS12175	COG0009	L-threonylcarbamoyladenylate synthase
WU42_RS12180	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WU42_RS12185	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WU42_RS12190	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
WU42_RS12200	COG2944	sequence-specific DNA binding
WU42_RS12210	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WU42_RS12265	COG1126	abc transporter atp-binding protein
WU42_RS12270	COG0765	amino acid transport
WU42_RS12275	COG0765	amino acid transport
WU42_RS12280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WU42_RS12290	COG2423	ornithine cyclodeaminase activity
WU42_RS12295	COG1764	response to oxidative stress
WU42_RS12305	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WU42_RS12310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WU42_RS12320	COG0189	ligase activity
WU42_RS12325	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WU42_RS12330	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WU42_RS12335	COG2197	response regulator
WU42_RS12345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WU42_RS12365	COG1289	transmembrane transporter activity
WU42_RS12375	COG3022	response to hydroperoxide
WU42_RS12385	COG1028	Short-chain dehydrogenase reductase Sdr
WU42_RS12400	COG3486	L-lysine 6-monooxygenase (NADPH) activity
WU42_RS12430	COG2814	Major facilitator Superfamily
WU42_RS12450	COG3706	GGDEF domain
WU42_RS12475	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WU42_RS12480	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WU42_RS12485	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
WU42_RS12490	COG1674	ftsk spoiiie
WU42_RS12495	COG0492	ferredoxin-NADP+ reductase activity
WU42_RS12500	COG1193	negative regulation of DNA recombination
WU42_RS12520	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WU42_RS12535	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
WU42_RS12540	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
WU42_RS12545	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
WU42_RS12550	COG2205	protein histidine kinase activity
WU42_RS12555	COG0745	RESPONSE REGULATOR receiver
WU42_RS12600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WU42_RS12620	COG0612	Peptidase, M16
WU42_RS12630	COG0443	Heat shock 70 kDa protein
WU42_RS12640	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WU42_RS12650	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WU42_RS12655	COG1420	regulation of RNA biosynthetic process
WU42_RS12660	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WU42_RS12665	COG0497	DNA recombination
WU42_RS12670	COG0735	belongs to the Fur family
WU42_RS12675	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WU42_RS12680	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WU42_RS12685	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WU42_RS12720	COG0446	pyridine nucleotide-disulphide oxidoreductase
WU42_RS12720	COG0404	The glycine cleavage system catalyzes the degradation of glycine
WU42_RS12725	COG4311	Sarcosine oxidase, delta subunit
WU42_RS12730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WU42_RS12740	COG0583	DNA-binding transcription factor activity
WU42_RS12750	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WU42_RS12780	COG4964	Belongs to the GSP D family
WU42_RS12840	COG0181	hydroxymethylbilane synthase activity
WU42_RS12845	COG0861	Integral membrane protein TerC family
WU42_RS12850	COG0861	Integral membrane protein TerC family
WU42_RS12855	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
WU42_RS12860	COG0045	succinate-CoA ligase (ADP-forming) activity
WU42_RS12870	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
WU42_RS12880	COG2137	regulation of response to DNA damage stimulus
WU42_RS12885	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WU42_RS12905	COG1250	3-hydroxyacyl-CoA dehydrogenase
WU42_RS12905	COG1024	Enoyl-CoA hydratase
WU42_RS12910	COG3842	ATPase activity
WU42_RS12925	COG1028	Short-chain dehydrogenase reductase Sdr
WU42_RS12945	COG0583	DNA-binding transcription factor activity
WU42_RS12950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU42_RS12960	COG2974	May be involved in recombination
WU42_RS12965	COG0540	Belongs to the ATCase OTCase family
WU42_RS13040	COG0776	regulation of translation
WU42_RS13045	COG0072	phenylalanine-tRNA ligase activity
WU42_RS13045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WU42_RS13050	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WU42_RS13055	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WU42_RS13060	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WU42_RS13075	COG0756	dUTP diphosphatase activity
WU42_RS13085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WU42_RS13100	COG0500	methyltransferase
WU42_RS13115	COG0586	Pfam SNARE associated Golgi protein
WU42_RS13145	COG1609	Transcriptional regulator
WU42_RS13150	COG4172	Belongs to the ABC transporter superfamily
WU42_RS13155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WU42_RS13160	COG0601	transmembrane transport
WU42_RS13165	COG0747	negative chemotaxis
WU42_RS13180	COG1280	lysine exporter protein (LysE YggA)
WU42_RS13195	COG2814	Major facilitator Superfamily
WU42_RS13225	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
WU42_RS13245	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
WU42_RS13285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WU42_RS13290	COG1116	anion transmembrane transporter activity
WU42_RS13300	COG1228	amidohydrolase
WU42_RS13315	COG0477	Major facilitator Superfamily
WU42_RS13325	COG3550	peptidyl-serine autophosphorylation
WU42_RS13340	COG0519	Catalyzes the synthesis of GMP from XMP
WU42_RS13340	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WU42_RS13385	COG0420	3'-5' exonuclease activity
WU42_RS13390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WU42_RS13420	COG0395	ABC-type sugar transport system, permease component
WU42_RS13430	COG3842	ATPase activity
WU42_RS13460	COG3181	Tripartite tricarboxylate transporter family receptor
WU42_RS13495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WU42_RS13520	COG0602	queuosine metabolic process
WU42_RS13525	COG0720	synthase
WU42_RS13530	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
WU42_RS13535	COG0235	Class ii aldolase
WU42_RS13560	COG3064	Membrane
WU42_RS13560	COG3210	domain, Protein
WU42_RS13560	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
WU42_RS13565	COG0047	phosphoribosylformylglycinamidine synthase activity
WU42_RS13565	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WU42_RS13570	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
WU42_RS13575	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
WU42_RS13575	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
WU42_RS13580	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
WU42_RS13600	COG3539	Fimbrial protein
WU42_RS13610	COG2050	protein possibly involved in aromatic compounds catabolism
WU42_RS13615	COG1024	Enoyl-CoA hydratase
WU42_RS13620	COG1012	belongs to the aldehyde dehydrogenase family
WU42_RS13630	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WU42_RS13635	COG2151	metal-sulfur cluster biosynthetic enzyme
WU42_RS13640	COG3396	Phenylacetate-CoA oxygenase
WU42_RS13645	COG3460	Phenylacetate-CoA oxygenase
WU42_RS13650	COG3396	Phenylacetate-CoA oxygenase
WU42_RS13655	COG3327	negative regulation of DNA-templated transcription, initiation
WU42_RS13665	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
WU42_RS13670	COG0501	Belongs to the peptidase M48B family
WU42_RS13675	COG1162	GTPase activity
WU42_RS13680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WU42_RS13685	COG0601	transmembrane transport
WU42_RS13690	COG0747	negative chemotaxis
WU42_RS13735	COG0668	transmembrane transport
WU42_RS13740	COG0165	Argininosuccinate lyase
WU42_RS13760	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
WU42_RS13765	COG0303	'Molybdopterin
WU42_RS13770	COG0521	Mo-molybdopterin cofactor biosynthetic process
WU42_RS13785	COG0315	cyclic pyranopterin monophosphate synthase activity
WU42_RS13795	COG0412	Dienelactone hydrolase
WU42_RS13805	COG0678	peroxiredoxin activity
WU42_RS13815	COG0697	spore germination
WU42_RS13820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WU42_RS13845	COG0789	Transcriptional regulator
WU42_RS13860	COG1028	Short-chain dehydrogenase reductase Sdr
WU42_RS13870	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
WU42_RS13875	COG1845	cytochrome c oxidase, subunit III
WU42_RS13880	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WU42_RS13890	COG0477	Major facilitator Superfamily
WU42_RS13920	COG3468	outer membrane autotransporter barrel domain protein
WU42_RS13930	COG1309	transcriptional regulator
WU42_RS13935	COG2271	Major facilitator Superfamily
WU42_RS13970	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
WU42_RS13970	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
WU42_RS13970	COG0506	proline dehydrogenase activity
WU42_RS13980	COG3008	intermembrane lipid transfer
WU42_RS13980	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WU42_RS13985	COG2995	paraquat-inducible protein a
WU42_RS13990	COG0542	response to heat
WU42_RS13995	COG4953	penicillin-binding protein 1C
WU42_RS14005	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
WU42_RS14010	COG1278	Cold shock
WU42_RS14020	COG0183	Belongs to the thiolase family
WU42_RS14025	COG0038	chloride channel
WU42_RS14030	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WU42_RS14035	COG1570	exodeoxyribonuclease VII activity
WU42_RS14045	COG0811	peptide transport
WU42_RS14050	COG0848	biopolymer transport protein
WU42_RS14055	COG1663	tetraacyldisaccharide 4'-kinase activity
WU42_RS14060	COG2835	tetraacyldisaccharide 4'-kinase activity
WU42_RS14065	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
WU42_RS14070	COG0563	adenylate kinase activity
WU42_RS14080	COG0728	peptidoglycan biosynthetic process
WU42_RS14090	COG0268	Binds directly to 16S ribosomal RNA
WU42_RS14120	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
WU42_RS14145	COG0436	Aminotransferase
WU42_RS14150	COG3737	Protein of unknown function (DUF498/DUF598)
WU42_RS14155	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WU42_RS14160	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
WU42_RS14165	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
WU42_RS14175	COG0305	Participates in initiation and elongation during chromosome replication
WU42_RS14185	COG0359	binds to the 23S rRNA
WU42_RS14190	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WU42_RS14195	COG2965	DNA replication, synthesis of RNA primer
WU42_RS14200	COG0360	Binds together with S18 to 16S ribosomal RNA
WU42_RS14205	COG1469	GTP cyclohydrolase I activity
WU42_RS14210	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
WU42_RS14215	COG0142	geranyltranstransferase activity
WU42_RS14220	COG1722	exodeoxyribonuclease VII activity
WU42_RS14230	COG3181	Tripartite tricarboxylate transporter family receptor
WU42_RS14250	COG2239	Acts as a magnesium transporter
WU42_RS14260	COG2855	membrane
WU42_RS14270	COG1473	amidohydrolase
WU42_RS14275	COG0318	PFAM AMP-dependent synthetase and ligase
WU42_RS14300	COG1501	Belongs to the glycosyl hydrolase 31 family
WU42_RS14305	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WU42_RS14310	COG2011	ABC-type metal ion transport system permease component
WU42_RS14330	COG1454	alcohol dehydrogenase
WU42_RS14360	COG2186	Transcriptional regulator
WU42_RS14365	COG3181	Tripartite tricarboxylate transporter family receptor
WU42_RS14385	COG1175	transmembrane transport
WU42_RS14390	COG0395	ABC-type sugar transport system, permease component
WU42_RS14395	COG3842	ATPase activity
WU42_RS14400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WU42_RS14410	COG1653	transport
WU42_RS14430	COG2818	Glycosylase
WU42_RS14435	COG2982	Protein involved in outer membrane biogenesis
WU42_RS14445	COG1309	transcriptional regulator
WU42_RS14450	COG1028	Short-chain dehydrogenase reductase Sdr
WU42_RS14510	COG0583	DNA-binding transcription factor activity
WU42_RS14515	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
WU42_RS14520	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
WU42_RS14535	COG1028	Short-chain dehydrogenase reductase Sdr
WU42_RS14540	COG0477	Major facilitator Superfamily
WU42_RS14550	COG0583	DNA-binding transcription factor activity
WU42_RS14555	COG1448	Aminotransferase
WU42_RS14560	COG1418	mRNA catabolic process
WU42_RS14585	COG1063	alcohol dehydrogenase
WU42_RS14605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WU42_RS14615	COG0318	PFAM AMP-dependent synthetase and ligase
WU42_RS14625	COG1522	sequence-specific DNA binding
WU42_RS14630	COG3181	Tripartite tricarboxylate transporter family receptor
WU42_RS14635	COG0307	riboflavin synthase, alpha
WU42_RS14640	COG0154	amidase activity
WU42_RS14660	COG2807	transmembrane transport
WU42_RS14665	COG0590	tRNA wobble adenosine to inosine editing
WU42_RS14675	COG0583	DNA-binding transcription factor activity
WU42_RS14690	COG1902	pentaerythritol trinitrate reductase activity
WU42_RS14710	COG0559	Belongs to the binding-protein-dependent transport system permease family
WU42_RS14715	COG0251	oxidation-reduction process
WU42_RS14720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WU42_RS14730	COG1414	Transcriptional regulator
WU42_RS14735	COG1028	Short-chain dehydrogenase reductase Sdr
WU42_RS14750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WU42_RS14765	COG1024	Enoyl-CoA hydratase
WU42_RS14770	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU42_RS14775	COG0154	amidase activity
WU42_RS14815	COG3909	cytochrome
WU42_RS14820	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WU42_RS14825	COG0625	glutathione transferase activity
WU42_RS14830	COG0730	response to heat
WU42_RS14835	COG0482	sulfurtransferase activity
WU42_RS14840	COG0583	DNA-binding transcription factor activity
WU42_RS14860	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
WU42_RS14885	COG2819	hydrolase of the alpha beta superfamily
WU42_RS14890	COG0247	lactate metabolic process
WU42_RS14895	COG0277	FAD linked oxidase domain protein
WU42_RS14900	COG0277	FAD linked oxidase domain protein
WU42_RS14905	COG0277	FAD linked oxidase domain protein
WU42_RS14910	COG3064	Membrane
WU42_RS14910	COG3210	domain, Protein
WU42_RS14910	COG3210	domain, Protein
WU42_RS14910	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
WU42_RS14910	COG3064	Membrane
WU42_RS14910	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
WU42_RS14915	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WU42_RS14920	COG0312	modulator of DNA gyrase
WU42_RS14955	COG1666	GTP binding
WU42_RS15000	COG3220	belongs to the UPF0276 family
WU42_RS15020	COG0640	Transcriptional regulator
WU42_RS15025	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
WU42_RS15030	COG1845	cytochrome c oxidase, subunit III
WU42_RS15035	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WU42_RS15045	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
WU42_RS15080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU42_RS15085	COG0583	DNA-binding transcription factor activity
WU42_RS15115	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WU42_RS15115	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WU42_RS15130	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WU42_RS15135	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WU42_RS15145	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WU42_RS15160	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
WU42_RS15165	COG0316	Belongs to the HesB IscA family
WU42_RS15175	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
WU42_RS15180	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
WU42_RS15185	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WU42_RS15190	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
WU42_RS15195	COG0312	modulator of DNA gyrase
WU42_RS15200	COG3028	Belongs to the UPF0307 family
WU42_RS15215	COG1116	anion transmembrane transporter activity
WU42_RS15220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WU42_RS15225	COG1335	isochorismatase
WU42_RS15230	COG0346	lactoylglutathione lyase activity
WU42_RS15235	COG0513	Belongs to the DEAD box helicase family
WU42_RS15240	COG3069	C4-dicarboxylate transmembrane transporter activity
WU42_RS15245	COG1802	Transcriptional regulator
WU42_RS15260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WU42_RS15260	COG1042	CoA-binding domain protein
WU42_RS15260	COG0045	succinate-CoA ligase (ADP-forming) activity
WU42_RS15265	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WU42_RS15280	COG1522	sequence-specific DNA binding
WU42_RS15315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WU42_RS15320	COG1696	Membrane protein involved in D-alanine export
WU42_RS15345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WU42_RS15355	COG2264	protein methyltransferase activity
WU42_RS15360	COG0439	Biotin carboxylase
WU42_RS15365	COG0511	ligase activity, forming carbon-carbon bonds
WU42_RS15370	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
WU42_RS15375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WU42_RS15380	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WU42_RS15385	COG3150	esterase
WU42_RS15390	COG0557	exoribonuclease II activity
WU42_RS15400	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
WU42_RS15420	COG1522	sequence-specific DNA binding
WU42_RS15425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WU42_RS15430	COG1028	Short-chain dehydrogenase reductase Sdr
WU42_RS15450	COG0653	protein targeting
WU42_RS15455	COG0739	heme binding
WU42_RS15465	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
WU42_RS15470	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
WU42_RS15480	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
WU42_RS15485	COG1181	Belongs to the D-alanine--D-alanine ligase family
WU42_RS15490	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WU42_RS15495	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WU42_RS15505	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WU42_RS15510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WU42_RS15515	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WU42_RS15525	COG3116	cell division
WU42_RS15530	COG0275	rRNA processing
WU42_RS15535	COG2001	Belongs to the MraZ family
WU42_RS15545	COG0488	(ABC) transporter
WU42_RS15550	COG0418	dihydroorotase activity
WU42_RS15555	COG1473	amidohydrolase
WU42_RS15605	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WU42_RS15610	COG4654	Cytochrome c, class I
WU42_RS15615	COG0129	dihydroxy-acid dehydratase activity
WU42_RS15620	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WU42_RS15675	COG2084	Dehydrogenase
WU42_RS15680	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
WU42_RS15695	COG2096	Adenosyltransferase
WU42_RS15705	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
WU42_RS15710	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
WU42_RS15720	COG0523	cobalamin synthesis protein
WU42_RS15725	COG0735	belongs to the Fur family
WU42_RS15745	COG0803	Belongs to the bacterial solute-binding protein 9 family
WU42_RS15755	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
WU42_RS15765	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
WU42_RS15775	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
WU42_RS15780	COG1560	Kdo2-lipid A biosynthetic process
WU42_RS15790	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
WU42_RS15805	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
WU42_RS15810	COG1950	PFAM Membrane protein of
WU42_RS15825	COG0583	DNA-binding transcription factor activity
WU42_RS15835	COG0477	Major facilitator Superfamily
WU42_RS15850	COG0617	tRNA 3'-terminal CCA addition
WU42_RS15860	COG0513	Belongs to the DEAD box helicase family
WU42_RS15865	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
WU42_RS15880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WU42_RS15885	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
WU42_RS15945	COG1280	lysine exporter protein (LysE YggA)
WU42_RS15960	COG0405	Gamma-glutamyltransferase
WU42_RS15970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WU42_RS16000	COG1309	transcriptional regulator
WU42_RS16010	COG3181	Tripartite tricarboxylate transporter family receptor
WU42_RS16020	COG0745	RESPONSE REGULATOR receiver
WU42_RS16085	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WU42_RS16110	COG0582	viral genome integration into host DNA
WU42_RS16115	COG0012	GTP binding
WU42_RS16125	COG0193	aminoacyl-tRNA hydrolase activity
WU42_RS16130	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WU42_RS16135	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WU42_RS16145	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
WU42_RS16150	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
WU42_RS16160	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WU42_RS16185	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
WU42_RS16195	COG1368	sulfuric ester hydrolase activity
WU42_RS16200	COG0642	Histidine kinase
WU42_RS16205	COG0745	RESPONSE REGULATOR receiver
WU42_RS16210	COG0277	FAD linked oxidase domain protein
WU42_RS16225	COG0166	Belongs to the GPI family
WU42_RS16230	COG0438	transferase activity, transferring glycosyl groups
WU42_RS16235	COG0438	transferase activity, transferring glycosyl groups
WU42_RS16250	COG0438	transferase activity, transferring glycosyl groups
WU42_RS16265	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
WU42_RS16270	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WU42_RS16275	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
WU42_RS16285	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
WU42_RS16295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WU42_RS16300	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WU42_RS16310	COG0747	negative chemotaxis
WU42_RS16315	COG0601	transmembrane transport
WU42_RS16320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WU42_RS16340	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
WU42_RS16345	COG0830	nickel cation binding
WU42_RS16355	COG0804	urea catabolic process
WU42_RS16360	COG0832	Belongs to the urease beta subunit family
WU42_RS16370	COG0831	urea catabolic process
WU42_RS16375	COG0829	nickel cation binding
WU42_RS16385	COG0633	Ferredoxin
WU42_RS16400	COG2188	Transcriptional regulator
WU42_RS16425	COG2719	SpoVR family
WU42_RS16430	COG2718	Belongs to the UPF0229 family
WU42_RS16445	COG1028	Short-chain dehydrogenase reductase Sdr
WU42_RS16450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU42_RS16465	COG1960	acyl-CoA dehydrogenase activity
WU42_RS16510	COG0183	Belongs to the thiolase family
WU42_RS16515	COG2030	dehydratase
WU42_RS16570	COG0328	RNA-DNA hybrid ribonuclease activity
WU42_RS16575	COG2226	methyltransferase
WU42_RS16580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WU42_RS16585	COG1388	LysM domain
WU42_RS16585	COG0741	lytic transglycosylase activity
WU42_RS16605	COG2979	Protein of unknown function (DUF533)
WU42_RS16640	COG1271	oxidase subunit
WU42_RS16645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WU42_RS16650	COG0850	regulation of cytokinetic process
WU42_RS16655	COG2894	cell division
WU42_RS16660	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
WU42_RS16680	COG0488	(ABC) transporter
WU42_RS16695	COG0601	transmembrane transport
WU42_RS16705	COG1215	transferase activity, transferring glycosyl groups
WU42_RS16720	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WU42_RS16730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WU42_RS16750	COG0318	PFAM AMP-dependent synthetase and ligase
WU42_RS16755	COG2188	Transcriptional regulator
WU42_RS16760	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
WU42_RS16765	COG2814	Major facilitator Superfamily
WU42_RS16775	COG0259	pyridoxamine-phosphate oxidase activity
WU42_RS16780	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
WU42_RS16795	COG0583	DNA-binding transcription factor activity
WU42_RS16800	COG1960	acyl-CoA dehydrogenase activity
WU42_RS16820	COG0134	indole-3-glycerol-phosphate synthase activity
WU42_RS16825	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WU42_RS16830	COG0512	Glutamine amidotransferase of anthranilate synthase
WU42_RS16840	COG0546	phosphoglycolate phosphatase activity
WU42_RS16845	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WU42_RS16850	COG2967	ApaG domain
WU42_RS16855	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
WU42_RS16860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WU42_RS16865	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WU42_RS16870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WU42_RS16880	COG0037	tRNA processing
WU42_RS16890	COG3634	alkyl hydroperoxide reductase activity
WU42_RS16895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WU42_RS16900	COG1024	Enoyl-CoA hydratase
WU42_RS16925	COG0356	it plays a direct role in the translocation of protons across the membrane
WU42_RS16935	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WU42_RS16940	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WU42_RS16945	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WU42_RS16950	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WU42_RS16955	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WU42_RS16960	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WU42_RS16970	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WU42_RS16975	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
WU42_RS16980	COG0210	DNA helicase
WU42_RS16990	COG2195	Cleaves the N-terminal amino acid of tripeptides
WU42_RS17000	COG4172	Belongs to the ABC transporter superfamily
WU42_RS17005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WU42_RS17010	COG0601	transmembrane transport
WU42_RS17030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
WU42_RS17035	COG1024	Enoyl-CoA hydratase
WU42_RS17040	COG1024	Enoyl-CoA hydratase
WU42_RS17065	COG1250	3-hydroxyacyl-CoA dehydrogenase
WU42_RS17095	COG2132	Multicopper oxidase
WU42_RS17105	COG1250	3-hydroxyacyl-CoA dehydrogenase
WU42_RS17105	COG1024	Enoyl-CoA hydratase
WU42_RS17115	COG1414	Transcriptional regulator
WU42_RS17125	COG0154	amidase activity
WU42_RS17155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WU42_RS17160	COG3568	Endonuclease Exonuclease Phosphatase
WU42_RS17165	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WU42_RS17200	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
WU42_RS17210	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
WU42_RS17225	COG1137	ATPase activity
WU42_RS17230	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
WU42_RS17240	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
WU42_RS17245	COG2010	Cytochrome c
WU42_RS17245	COG1529	Aldehyde oxidase and xanthine dehydrogenase
WU42_RS17255	COG1660	Displays ATPase and GTPase activities
WU42_RS17260	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
WU42_RS17295	COG3181	Tripartite tricarboxylate transporter family receptor
WU42_RS17305	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
WU42_RS17310	COG2890	protein-(glutamine-N5) methyltransferase activity
WU42_RS17315	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WU42_RS17320	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
WU42_RS17370	COG1960	acyl-CoA dehydrogenase activity
WU42_RS17380	COG0183	Belongs to the thiolase family
WU42_RS17385	COG1522	sequence-specific DNA binding
WU42_RS17390	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WU42_RS17410	COG1024	Enoyl-CoA hydratase
WU42_RS17425	COG0604	alcohol dehydrogenase
WU42_RS17445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WU42_RS17455	COG1960	acyl-CoA dehydrogenase activity
WU42_RS17460	COG1960	acyl-CoA dehydrogenase activity
WU42_RS17465	COG0277	FAD linked oxidase domain protein
WU42_RS17475	COG3181	Tripartite tricarboxylate transporter family receptor
WU42_RS17500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WU42_RS17510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU42_RS17515	COG3181	Tripartite tricarboxylate transporter family receptor
WU42_RS17520	COG1960	acyl-CoA dehydrogenase activity
WU42_RS17540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WU42_RS17545	COG1024	Enoyl-CoA hydratase
WU42_RS17550	COG1960	acyl-CoA dehydrogenase activity
WU42_RS17570	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WU42_RS17575	COG0022	dehydrogenase e1 component
WU42_RS17580	COG1024	Enoyl-CoA hydratase
WU42_RS17585	COG0508	dehydrogenase complex catalyzes the overall conversion of
WU42_RS17605	COG0683	leucine binding
WU42_RS17610	COG0559	Belongs to the binding-protein-dependent transport system permease family
WU42_RS17615	COG0411	ABC transporter
WU42_RS17625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WU42_RS17640	COG3181	Tripartite tricarboxylate transporter family receptor
WU42_RS17670	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WU42_RS17675	COG0793	Belongs to the peptidase S41A family
WU42_RS17680	COG4942	peptidase
WU42_RS17685	COG0588	phosphoglycerate mutase activity
WU42_RS17690	COG1054	Belongs to the UPF0176 family
WU42_RS17695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
WU42_RS17700	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
WU42_RS17705	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WU42_RS17710	COG3181	Tripartite tricarboxylate transporter family receptor
WU42_RS17725	COG2226	methyltransferase
WU42_RS17730	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
WU42_RS17745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WU42_RS17750	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
WU42_RS17775	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
WU42_RS17800	COG1335	isochorismatase
WU42_RS17805	COG2309	aminopeptidase activity
WU42_RS17810	COG0596	Alpha beta hydrolase
WU42_RS17815	COG3473	Maleate cis-trans isomerase
WU42_RS17825	COG2068	MobA-Related Protein
WU42_RS17850	COG2204	response regulator
WU42_RS17855	COG5000	phosphorelay sensor kinase activity
WU42_RS17865	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WU42_RS17865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WU42_RS17875	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
WU42_RS17905	COG0583	DNA-binding transcription factor activity
WU42_RS17920	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
WU42_RS17925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WU42_RS17930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WU42_RS17945	COG0758	DNA mediated transformation
WU42_RS17950	COG1522	sequence-specific DNA binding
WU42_RS17960	COG0242	peptide deformylase activity
WU42_RS17975	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WU42_RS17985	COG0546	phosphoglycolate phosphatase activity
WU42_RS18005	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WU42_RS18010	COG1942	4-Oxalocrotonate Tautomerase
WU42_RS18015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WU42_RS18040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WU42_RS18060	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WU42_RS18065	COG1024	Enoyl-CoA hydratase
WU42_RS18070	COG1414	Transcriptional regulator
WU42_RS18075	COG0318	PFAM AMP-dependent synthetase and ligase
WU42_RS18080	COG3181	Tripartite tricarboxylate transporter family receptor
WU42_RS18110	COG0583	DNA-binding transcription factor activity
WU42_RS18125	COG3422	double-strand break repair
WU42_RS18130	COG0330	HflC and HflK could
WU42_RS18140	COG0251	oxidation-reduction process
WU42_RS18185	COG3723	Recombinational DNA repair protein, rece pathway
WU42_RS18220	COG0582	viral genome integration into host DNA
WU42_RS18245	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
WU42_RS18255	COG0706	membrane insertase activity
WU42_RS18260	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
WU42_RS18265	COG0594	ribonuclease P activity
WU42_RS18270	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WU42_RS18275	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WU42_RS18290	COG1414	Transcriptional regulator
WU42_RS18295	COG0154	amidase activity
WU42_RS18310	COG1304	FMN binding
WU42_RS18330	COG1960	acyl-CoA dehydrogenase activity
WU42_RS18350	COG1960	acyl-CoA dehydrogenase activity
WU42_RS18365	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WU42_RS18380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WU42_RS18385	COG3181	Tripartite tricarboxylate transporter family receptor
WU42_RS18395	COG2358	TRAP transporter, solute receptor (TAXI family
WU42_RS18405	COG1629	transport
WU42_RS18410	COG2922	Belongs to the Smg family
WU42_RS18435	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
WU42_RS18440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WU42_RS18445	COG1028	Short-chain dehydrogenase reductase Sdr
WU42_RS18450	COG1012	belongs to the aldehyde dehydrogenase family
WU42_RS18460	COG0028	Belongs to the TPP enzyme family
WU42_RS18465	COG1522	sequence-specific DNA binding
WU42_RS18470	COG3781	membrane
WU42_RS18480	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WU42_RS18500	COG4206	TonB-dependent receptor
WU42_RS18505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WU42_RS18510	COG2022	thiamine diphosphate biosynthetic process
WU42_RS18515	COG0351	phosphomethylpyrimidine kinase
WU42_RS18520	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
WU42_RS18535	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
WU42_RS18545	COG0628	permease
WU42_RS18555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
WU42_RS18565	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WU42_RS18570	COG0049	tRNA binding
WU42_RS18575	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WU42_RS18580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WU42_RS18585	COG0051	transcription antitermination factor activity, RNA binding
WU42_RS18590	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WU42_RS18595	COG0088	Forms part of the polypeptide exit tunnel
WU42_RS18600	COG0089	rRNA binding
WU42_RS18605	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WU42_RS18610	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WU42_RS18615	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WU42_RS18620	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WU42_RS18625	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WU42_RS18630	COG0255	Belongs to the universal ribosomal protein uL29 family
WU42_RS18635	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WU42_RS18655	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WU42_RS18660	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WU42_RS18665	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WU42_RS18670	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WU42_RS18675	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WU42_RS18680	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WU42_RS18685	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WU42_RS18690	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WU42_RS18695	COG1841	ribosomal large subunit assembly
WU42_RS18700	COG0200	Binds to the 23S rRNA
WU42_RS18705	COG0201	protein transport
WU42_RS18710	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WU42_RS18715	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WU42_RS18720	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WU42_RS18725	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WU42_RS18730	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WU42_RS18735	COG0202	RNA polymerase activity
WU42_RS18740	COG0203	ribosomal protein L17
WU42_RS18745	COG0537	adenosine 5'-monophosphoramidase activity
WU42_RS18750	COG1324	tolerance protein
WU42_RS18755	COG4232	protein-disulfide reductase activity
WU42_RS18770	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WU42_RS18780	COG1333	cytochrome c biogenesis protein
WU42_RS18785	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WU42_RS18800	COG1965	Belongs to the frataxin family
WU42_RS18810	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
WU42_RS18815	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
WU42_RS18820	COG0232	Belongs to the dGTPase family. Type 2 subfamily
WU42_RS18835	COG2814	Major facilitator Superfamily
WU42_RS18840	COG0629	single-stranded DNA binding
WU42_RS18880	COG0402	S-adenosylhomocysteine deaminase activity
WU42_RS18890	COG0438	transferase activity, transferring glycosyl groups
WU42_RS18910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WU42_RS18935	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
WU42_RS18940	COG2186	Transcriptional regulator
WU42_RS18960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WU42_RS18965	COG1956	GAF domain-containing protein
WU42_RS18970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WU42_RS18985	COG1652	LysM domain
WU42_RS19000	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WU42_RS19015	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WU42_RS19045	COG3181	Tripartite tricarboxylate transporter family receptor
WU42_RS19060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WU42_RS19075	COG1024	Enoyl-CoA hydratase
WU42_RS19090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU42_RS19095	COG1309	transcriptional regulator
WU42_RS19100	COG2816	NAD+ diphosphatase activity
WU42_RS19105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WU42_RS19190	COG2814	Major facilitator Superfamily
WU42_RS19195	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WU42_RS19215	COG1999	signal sequence binding
WU42_RS19220	COG0109	protoheme IX farnesyltransferase activity
WU42_RS19260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WU42_RS19280	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
WU42_RS19285	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WU42_RS19295	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
WU42_RS19300	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
WU42_RS19310	COG0070	glutamate synthase
WU42_RS19310	COG0069	glutamate synthase activity
WU42_RS19310	COG0067	glutamate synthase
WU42_RS19320	COG3047	cAMP biosynthetic process
WU42_RS19330	COG1127	ABC transporter
WU42_RS19335	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WU42_RS19340	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WU42_RS19345	COG2853	Lipoprotein
WU42_RS19355	COG1131	(ABC) transporter
WU42_RS19360	COG0842	Transport permease protein
WU42_RS19370	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WU42_RS19375	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
WU42_RS19380	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
WU42_RS19385	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
WU42_RS19390	COG0131	Imidazoleglycerol-phosphate dehydratase
WU42_RS19395	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
WU42_RS19400	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
WU42_RS19405	COG0107	imidazoleglycerol-phosphate synthase activity
WU42_RS19410	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
WU42_RS19415	COG0140	phosphoribosyl-ATP diphosphatase activity
WU42_RS19420	COG0537	adenosine 5'-monophosphoramidase activity
WU42_RS19425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WU42_RS19430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WU42_RS19445	COG3181	Tripartite tricarboxylate transporter family receptor
WU42_RS19480	COG3702	type iv secretory pathway
WU42_RS19485	COG3451	type IV secretory pathway VirB4
WU42_RS19500	COG3736	Type IV secretory pathway, component VirB8
WU42_RS19505	COG3504	Conjugal transfer protein
WU42_RS19510	COG2948	multi-organism process
WU42_RS19515	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
WU42_RS19525	COG0697	spore germination
WU42_RS19545	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WU42_RS19550	COG0747	negative chemotaxis
WU42_RS19555	COG0601	transmembrane transport
WU42_RS19560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WU42_RS19565	COG0444	Belongs to the ABC transporter superfamily
WU42_RS19575	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
WU42_RS19585	COG0494	nUDIX hydrolase
WU42_RS19625	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
WU42_RS19630	COG0237	dephospho-CoA kinase activity
WU42_RS19635	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
WU42_RS19650	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
WU42_RS19655	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
WU42_RS19665	COG0477	Major facilitator Superfamily
WU42_RS19670	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
WU42_RS19685	COG1126	abc transporter atp-binding protein
WU42_RS19690	COG0765	amino acid transport
WU42_RS19695	COG4597	amino acid ABC transporter
WU42_RS19700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WU42_RS19705	COG2884	Cell division ATP-binding protein ftsE
WU42_RS19710	COG2177	Part of the ABC transporter FtsEX involved in
WU42_RS19715	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
WU42_RS19725	COG1194	a g-specific adenine glycosylase
WU42_RS19735	COG2226	methyltransferase
WU42_RS19745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU42_RS19750	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU42_RS19765	COG1024	Enoyl-CoA hydratase
WU42_RS19785	COG1024	Enoyl-CoA hydratase
WU42_RS19790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WU42_RS19795	COG3181	Tripartite tricarboxylate transporter family receptor
WU42_RS19805	COG0753	catalase activity
WU42_RS19810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WU42_RS19815	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
WU42_RS19825	COG2175	clavaminate synthase activity
WU42_RS19830	COG1473	amidohydrolase
WU42_RS19835	COG4608	Belongs to the ABC transporter superfamily
WU42_RS19840	COG0444	Belongs to the ABC transporter superfamily
WU42_RS19855	COG0747	negative chemotaxis
WU42_RS19860	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WU42_RS19895	COG0436	Aminotransferase
WU42_RS19900	COG1278	Cold shock