locus-tag	class	description
XA18_RS00005	COG0445	tRNA wobble uridine modification
XA18_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
XA18_RS00015	COG1192	Involved in chromosome partitioning
XA18_RS00025	COG1475	DNA binding
XA18_RS00050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XA18_RS00060	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XA18_RS00070	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XA18_RS00075	COG0081	regulation of translation
XA18_RS00080	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XA18_RS00085	COG0222	ribosome binding
XA18_RS00090	COG0085	RNA polymerase activity
XA18_RS00095	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XA18_RS00135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
XA18_RS00160	COG1024	Enoyl-CoA hydratase
XA18_RS00180	COG0752	glycyl-tRNA synthetase alpha subunit
XA18_RS00185	COG0751	glycine-tRNA ligase activity
XA18_RS00190	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XA18_RS00195	COG0204	Acyl-transferase
XA18_RS00210	COG0242	peptide deformylase activity
XA18_RS00250	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XA18_RS00255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XA18_RS00255	COG2813	Specifically methylates the guanine in position
XA18_RS00270	COG2223	nitrite transmembrane transporter activity
XA18_RS00280	COG1794	racemase activity, acting on amino acids and derivatives
XA18_RS00285	COG1126	abc transporter atp-binding protein
XA18_RS00290	COG0765	amino acid transport
XA18_RS00295	COG0765	amino acid transport
XA18_RS00300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XA18_RS00365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
XA18_RS00395	COG0326	Molecular chaperone. Has ATPase activity
XA18_RS00400	COG0625	glutathione transferase activity
XA18_RS00415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XA18_RS00420	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XA18_RS00450	COG0438	transferase activity, transferring glycosyl groups
XA18_RS00455	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
XA18_RS00460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
XA18_RS00490	COG0859	PFAM glycosyl transferase family 9
XA18_RS00505	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
XA18_RS00515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XA18_RS00520	COG1127	ABC transporter
XA18_RS00540	COG1686	Belongs to the peptidase S11 family
XA18_RS00550	COG2921	Belongs to the UPF0250 family
XA18_RS00555	COG0321	lipoyl(octanoyl) transferase activity
XA18_RS00560	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XA18_RS00595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XA18_RS00605	COG0018	arginyl-trna synthetase
XA18_RS00625	COG0395	ABC-type sugar transport system, permease component
XA18_RS00630	COG1175	transmembrane transport
XA18_RS00635	COG1653	transport
XA18_RS00640	COG3842	ATPase activity
XA18_RS00645	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
XA18_RS00655	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XA18_RS00675	COG1609	Transcriptional regulator
XA18_RS00685	COG0154	amidase activity
XA18_RS00690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XA18_RS00700	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
XA18_RS00710	COG0583	DNA-binding transcription factor activity
XA18_RS00730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
XA18_RS00745	COG1802	Transcriptional regulator
XA18_RS00760	COG1024	Enoyl-CoA hydratase
XA18_RS00775	COG3181	Tripartite tricarboxylate transporter family receptor
XA18_RS00790	COG1984	allophanate hydrolase subunit 2
XA18_RS00795	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
XA18_RS00805	COG0583	DNA-binding transcription factor activity
XA18_RS00810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XA18_RS00820	COG5002	protein histidine kinase activity
XA18_RS00830	COG5002	protein histidine kinase activity
XA18_RS00835	COG0745	RESPONSE REGULATOR receiver
XA18_RS00840	COG2226	methyltransferase
XA18_RS00855	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XA18_RS00875	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
XA18_RS00885	COG0513	Belongs to the DEAD box helicase family
XA18_RS00890	COG1280	lysine exporter protein (LysE YggA)
XA18_RS00895	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XA18_RS00930	COG1054	Belongs to the UPF0176 family
XA18_RS00935	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XA18_RS00935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XA18_RS00945	COG0489	protein tyrosine kinase activity
XA18_RS00960	COG0717	Belongs to the dCTP deaminase family
XA18_RS00990	COG2081	HI0933 family
XA18_RS01000	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XA18_RS01010	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XA18_RS01015	COG0509	glycine decarboxylation via glycine cleavage system
XA18_RS01020	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XA18_RS01020	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XA18_RS01060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XA18_RS01075	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
XA18_RS01085	COG1414	Transcriptional regulator
XA18_RS01090	COG1028	Short-chain dehydrogenase reductase Sdr
XA18_RS01095	COG2031	fatty acid transporter
XA18_RS01100	COG1250	3-hydroxyacyl-CoA dehydrogenase
XA18_RS01110	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
XA18_RS01115	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XA18_RS01125	COG4257	antibiotic catabolic process
XA18_RS01150	COG1012	belongs to the aldehyde dehydrogenase family
XA18_RS01155	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XA18_RS01160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XA18_RS01185	COG1028	Short-chain dehydrogenase reductase Sdr
XA18_RS01195	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XA18_RS01205	COG2188	Transcriptional regulator
XA18_RS01210	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
XA18_RS01235	COG0617	tRNA 3'-terminal CCA addition
XA18_RS01250	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XA18_RS01255	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XA18_RS01260	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XA18_RS01265	COG0586	Pfam SNARE associated Golgi protein
XA18_RS01270	COG0860	N-Acetylmuramoyl-L-alanine amidase
XA18_RS01275	COG0802	atpase or kinase
XA18_RS01280	COG0114	fumarate hydratase activity
XA18_RS01290	COG3181	Tripartite tricarboxylate transporter family receptor
XA18_RS01300	COG0405	Gamma-glutamyltransferase
XA18_RS01305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
XA18_RS01340	COG1294	oxidase, subunit
XA18_RS01350	COG4988	ABC transporter
XA18_RS01355	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
XA18_RS01405	COG2969	positive regulation of protein catabolic process
XA18_RS01410	COG0625	glutathione transferase activity
XA18_RS01415	COG2857	Cytochrome c1
XA18_RS01420	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XA18_RS01425	COG0723	plastoquinol--plastocyanin reductase activity
XA18_RS01430	COG1970	mechanosensitive ion channel activity
XA18_RS01435	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
XA18_RS01450	COG2808	Putative FMN-binding domain
XA18_RS01455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XA18_RS01460	COG0747	negative chemotaxis
XA18_RS01465	COG0657	acetylesterase activity
XA18_RS01475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XA18_RS01480	COG2207	Transcriptional regulator
XA18_RS01485	COG0129	dihydroxy-acid dehydratase activity
XA18_RS01490	COG2814	Major facilitator Superfamily
XA18_RS01495	COG0583	DNA-binding transcription factor activity
XA18_RS01505	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
XA18_RS01575	COG1024	Enoyl-CoA hydratase
XA18_RS01580	COG1960	acyl-CoA dehydrogenase activity
XA18_RS01605	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XA18_RS01610	COG0352	thiamine-phosphate diphosphorylase activity
XA18_RS01625	COG1678	Uncharacterized ACR, COG1678
XA18_RS01630	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
XA18_RS01635	COG0540	Belongs to the ATCase OTCase family
XA18_RS01650	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XA18_RS01660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XA18_RS01695	COG1234	tRNA 3'-trailer cleavage
XA18_RS01715	COG3064	Membrane
XA18_RS01745	COG1683	Conserved Protein
XA18_RS01750	COG1120	ATPase activity
XA18_RS01755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XA18_RS01760	COG4558	Periplasmic binding protein
XA18_RS01765	COG3720	iron ion transport
XA18_RS01775	COG3712	iron ion homeostasis
XA18_RS01780	COG1595	DNA-templated transcription, initiation
XA18_RS01815	COG1802	Transcriptional regulator
XA18_RS01825	COG3069	C4-dicarboxylate transmembrane transporter activity
XA18_RS01835	COG1012	belongs to the aldehyde dehydrogenase family
XA18_RS01870	COG2860	membrane
XA18_RS01875	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
XA18_RS01880	COG0708	Exodeoxyribonuclease III
XA18_RS01885	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XA18_RS01890	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
XA18_RS01895	COG0154	amidase activity
XA18_RS01900	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
XA18_RS01905	COG1077	Cell shape determining protein MreB Mrl
XA18_RS01910	COG1792	Involved in formation and maintenance of cell shape
XA18_RS01920	COG0768	penicillin binding
XA18_RS01925	COG0772	Belongs to the SEDS family
XA18_RS01930	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
XA18_RS01935	COG0471	metal ion transport
XA18_RS01940	COG1309	transcriptional regulator
XA18_RS01950	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XA18_RS01965	COG2823	Periplasmic or secreted lipoprotein
XA18_RS01970	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
XA18_RS01985	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
XA18_RS02005	COG1804	L-carnitine dehydratase bile acid-inducible protein F
XA18_RS02015	COG1804	L-carnitine dehydratase bile acid-inducible protein F
XA18_RS02035	COG0492	ferredoxin-NADP+ reductase activity
XA18_RS02045	COG3181	Tripartite tricarboxylate transporter family receptor
XA18_RS02050	COG1250	3-hydroxyacyl-CoA dehydrogenase
XA18_RS02050	COG1024	Enoyl-CoA hydratase
XA18_RS02055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
XA18_RS02060	COG0028	Belongs to the TPP enzyme family
XA18_RS02085	COG3181	Tripartite tricarboxylate transporter family receptor
XA18_RS02100	COG0697	spore germination
XA18_RS02130	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
XA18_RS02135	COG0463	Glycosyl transferase, family 2
XA18_RS02150	COG0786	glutamate:sodium symporter activity
XA18_RS02160	COG2031	fatty acid transporter
XA18_RS02175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XA18_RS02190	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XA18_RS02205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XA18_RS02215	COG1285	pathogenesis
XA18_RS02220	COG1253	flavin adenine dinucleotide binding
XA18_RS02225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
XA18_RS02230	COG1024	Enoyl-CoA hydratase
XA18_RS02235	COG3181	Tripartite tricarboxylate transporter family receptor
XA18_RS02240	COG0583	DNA-binding transcription factor activity
XA18_RS02245	COG1960	acyl-CoA dehydrogenase activity
XA18_RS02255	COG0183	Belongs to the thiolase family
XA18_RS02275	COG0583	DNA-binding transcription factor activity
XA18_RS02280	COG1278	Cold shock
XA18_RS02290	COG1802	Transcriptional regulator
XA18_RS02295	COG1012	belongs to the aldehyde dehydrogenase family
XA18_RS02300	COG2031	fatty acid transporter
XA18_RS02305	COG1017	nitric oxide dioxygenase activity
XA18_RS02305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
XA18_RS02310	COG0251	oxidation-reduction process
XA18_RS02330	COG1804	L-carnitine dehydratase bile acid-inducible protein F
XA18_RS02340	COG0583	DNA-binding transcription factor activity
XA18_RS02345	COG1804	L-carnitine dehydratase bile acid-inducible protein F
XA18_RS02360	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
XA18_RS02365	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
XA18_RS02370	COG0546	phosphoglycolate phosphatase activity
XA18_RS02380	COG1530	ribonuclease E activity
XA18_RS02400	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XA18_RS02405	COG0159	tryptophan synthase activity
XA18_RS02410	COG0133	tryptophan synthase activity
XA18_RS02420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XA18_RS02425	COG3228	Belongs to the MtfA family
XA18_RS02435	COG0251	oxidation-reduction process
XA18_RS02440	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XA18_RS02445	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
XA18_RS02460	COG2878	Part of a membrane complex involved in electron transport
XA18_RS02465	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XA18_RS02500	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XA18_RS02520	COG1268	BioY protein
XA18_RS02525	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
XA18_RS02530	COG1122	ATPase activity
XA18_RS02535	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XA18_RS02550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XA18_RS02555	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XA18_RS02565	COG1196	nuclear chromosome segregation
XA18_RS02570	COG0477	Major facilitator Superfamily
XA18_RS02575	COG1573	uracil-dna glycosylase
XA18_RS02580	COG1214	PFAM Peptidase M22, glycoprotease
XA18_RS02600	COG0450	alkyl hydroperoxide reductase
XA18_RS02605	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XA18_RS02615	COG2223	nitrite transmembrane transporter activity
XA18_RS02625	COG2186	Transcriptional regulator
XA18_RS02645	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XA18_RS02655	COG0583	DNA-binding transcription factor activity
XA18_RS02665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XA18_RS02670	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XA18_RS02675	COG0137	argininosuccinate synthase activity
XA18_RS02680	COG3158	transport of potassium into the cell
XA18_RS02685	COG0642	Histidine kinase
XA18_RS02715	COG0776	regulation of translation
XA18_RS02720	COG3128	pkhd-type hydroxylase
XA18_RS02730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XA18_RS02735	COG0557	exoribonuclease II activity
XA18_RS02760	COG0679	Auxin Efflux Carrier
XA18_RS02765	COG2391	methyltransferase activity
XA18_RS02770	COG0069	glutamate synthase activity
XA18_RS02785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XA18_RS02795	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
XA18_RS02835	COG3706	GGDEF domain
XA18_RS02855	COG1053	succinate dehydrogenase
XA18_RS02860	COG0583	DNA-binding transcription factor activity
XA18_RS02870	COG1053	succinate dehydrogenase
XA18_RS02890	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
XA18_RS02895	COG0459	protein refolding
XA18_RS02900	COG3468	outer membrane autotransporter barrel domain protein
XA18_RS02915	COG1252	NADH dehydrogenase
XA18_RS02920	COG0284	orotidine-5'-phosphate decarboxylase activity
XA18_RS02925	COG1058	Belongs to the CinA family
XA18_RS02925	COG1546	Belongs to the CinA family
XA18_RS02930	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
XA18_RS02940	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XA18_RS02945	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XA18_RS02985	COG3639	organic phosphonate transmembrane transporter activity
XA18_RS02990	COG3639	organic phosphonate transmembrane transporter activity
XA18_RS03010	COG0742	ribosomal rna small subunit methyltransferase
XA18_RS03015	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XA18_RS03020	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XA18_RS03025	COG3135	benzoate transporter
XA18_RS03040	COG0640	Transcriptional regulator
XA18_RS03070	COG4172	Belongs to the ABC transporter superfamily
XA18_RS03075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XA18_RS03080	COG0601	transmembrane transport
XA18_RS03090	COG0280	phosphate acetyltransferase
XA18_RS03090	COG0281	malic enzyme
XA18_RS03150	COG0583	DNA-binding transcription factor activity
XA18_RS03165	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
XA18_RS03170	COG0167	dihydroorotate dehydrogenase activity
XA18_RS03190	COG1414	Transcriptional regulator
XA18_RS03195	COG1058	Belongs to the CinA family
XA18_RS03195	COG1546	Belongs to the CinA family
XA18_RS03215	COG0513	Belongs to the DEAD box helicase family
XA18_RS03245	COG0429	hydrolase of the alpha beta-hydrolase fold
XA18_RS03250	COG4783	chaperone-mediated protein folding
XA18_RS03265	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
XA18_RS03290	COG0006	proline dipeptidase activity
XA18_RS03300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XA18_RS03320	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XA18_RS03325	COG0632	four-way junction helicase activity
XA18_RS03340	COG2255	four-way junction helicase activity
XA18_RS03345	COG0514	ATP-dependent DNA helicase (RecQ)
XA18_RS03360	COG0288	reversible hydration of carbon dioxide
XA18_RS03365	COG0154	amidase activity
XA18_RS03375	COG4211	Belongs to the binding-protein-dependent transport system permease family
XA18_RS03405	COG1464	Belongs to the NlpA lipoprotein family
XA18_RS03545	COG1196	nuclear chromosome segregation
XA18_RS03615	COG2135	peptidase activity
XA18_RS03630	COG0494	nUDIX hydrolase
XA18_RS03635	COG0442	prolyl-tRNA aminoacylation
XA18_RS03640	COG0824	Thioesterase
XA18_RS03645	COG0811	peptide transport
XA18_RS03650	COG0848	biopolymer transport protein
XA18_RS03660	COG0823	Involved in the tonB-independent uptake of proteins
XA18_RS03675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XA18_RS03680	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
XA18_RS03715	COG0700	Nucleoside recognition
XA18_RS03720	COG0469	pyruvate kinase activity
XA18_RS03725	COG1929	Belongs to the glycerate kinase type-1 family
XA18_RS03730	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XA18_RS03735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XA18_RS03740	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XA18_RS03750	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XA18_RS03760	COG2154	pterin-4-alpha-carbinolamine dehydratase
XA18_RS03785	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
XA18_RS03790	COG0154	amidase activity
XA18_RS03800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XA18_RS03805	COG0601	transmembrane transport
XA18_RS03810	COG0747	negative chemotaxis
XA18_RS03830	COG0019	diaminopimelate decarboxylase activity
XA18_RS03845	COG2353	YceI-like domain
XA18_RS03850	COG4774	siderophore transport
XA18_RS03855	COG3712	iron ion homeostasis
XA18_RS03895	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XA18_RS03900	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XA18_RS03905	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XA18_RS03910	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XA18_RS03920	COG0142	geranyltranstransferase activity
XA18_RS03930	COG0583	DNA-binding transcription factor activity
XA18_RS03940	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
XA18_RS03945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XA18_RS03960	COG2994	toxin metabolic process
XA18_RS03970	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
XA18_RS03975	COG2274	protein secretion by the type I secretion system
XA18_RS03980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XA18_RS03985	COG1538	Outer membrane efflux protein
XA18_RS04005	COG0765	amino acid transport
XA18_RS04010	COG1126	abc transporter atp-binding protein
XA18_RS04030	COG1028	Short-chain dehydrogenase reductase Sdr
XA18_RS04040	COG1802	Transcriptional regulator
XA18_RS04050	COG1802	Transcriptional regulator
XA18_RS04060	COG0318	PFAM AMP-dependent synthetase and ligase
XA18_RS04070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XA18_RS04090	COG0028	Belongs to the TPP enzyme family
XA18_RS04110	COG0308	aminopeptidase N
XA18_RS04115	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
XA18_RS04130	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XA18_RS04135	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XA18_RS04140	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XA18_RS04145	COG0560	Phosphoserine phosphatase
XA18_RS04150	COG0583	DNA-binding transcription factor activity
XA18_RS04155	COG3181	Tripartite tricarboxylate transporter family receptor
XA18_RS04160	COG0028	Belongs to the TPP enzyme family
XA18_RS04175	COG4774	siderophore transport
XA18_RS04180	COG4774	siderophore transport
XA18_RS04190	COG1007	ATP synthesis coupled electron transport
XA18_RS04205	COG0713	ATP synthesis coupled electron transport
XA18_RS04215	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XA18_RS04220	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
XA18_RS04225	COG1034	ATP synthesis coupled electron transport
XA18_RS04235	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XA18_RS04240	COG0649	NAD binding
XA18_RS04245	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XA18_RS04250	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XA18_RS04255	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XA18_RS04260	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
XA18_RS04290	COG0671	phosphoesterase, PA-phosphatase related
XA18_RS04300	COG1597	lipid kinase activity
XA18_RS04305	COG0583	DNA-binding transcription factor activity
XA18_RS04310	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
XA18_RS04320	COG1733	regulation of RNA biosynthetic process
XA18_RS04325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XA18_RS04330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XA18_RS04345	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
XA18_RS04365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XA18_RS04385	COG3608	succinylglutamate desuccinylase aspartoacylase
XA18_RS04390	COG0626	cystathionine gamma-synthase activity
XA18_RS04395	COG0583	DNA-binding transcription factor activity
XA18_RS04430	COG3799	methylaspartate ammonia-lyase activity
XA18_RS04440	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
XA18_RS04450	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XA18_RS04455	COG0149	triose-phosphate isomerase activity
XA18_RS04475	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
XA18_RS04490	COG1185	polyribonucleotide nucleotidyltransferase activity
XA18_RS04495	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
XA18_RS04510	COG1183	phosphatidylcholine synthase activity
XA18_RS04515	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XA18_RS04520	COG0440	acetolactate synthase activity
XA18_RS04525	COG0028	Belongs to the TPP enzyme family
XA18_RS04540	COG5265	(ABC) transporter
XA18_RS04545	COG0500	methyltransferase
XA18_RS04565	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
XA18_RS04585	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
XA18_RS04595	COG0511	ligase activity, forming carbon-carbon bonds
XA18_RS04620	COG2188	Transcriptional regulator
XA18_RS04625	COG0439	Biotin carboxylase
XA18_RS04675	COG5265	(ABC) transporter
XA18_RS04685	COG0667	Aldo Keto reductase
XA18_RS04700	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XA18_RS04740	COG0583	DNA-binding transcription factor activity
XA18_RS04770	COG2814	Major facilitator Superfamily
XA18_RS04780	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XA18_RS04795	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XA18_RS04805	COG0287	Prephenate dehydrogenase
XA18_RS04810	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XA18_RS04815	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XA18_RS04835	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XA18_RS04840	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
XA18_RS04845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XA18_RS04850	COG1596	polysaccharide export
XA18_RS04850	COG1555	photosystem II stabilization
XA18_RS04865	COG2951	lytic endotransglycosylase activity
XA18_RS04870	COG0123	including yeast histone deacetylase and acetoin utilization protein
XA18_RS04885	COG1960	acyl-CoA dehydrogenase activity
XA18_RS04890	COG0450	alkyl hydroperoxide reductase
XA18_RS04910	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XA18_RS04945	COG0335	large ribosomal subunit rRNA binding
XA18_RS04960	COG0667	Aldo Keto reductase
XA18_RS04975	COG3161	chorismate lyase activity
XA18_RS04980	COG1187	pseudouridine synthase activity
XA18_RS05010	COG1999	signal sequence binding
XA18_RS05015	COG0339	signal peptide processing
XA18_RS05020	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XA18_RS05025	COG4566	intracellular signal transduction
XA18_RS05035	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
XA18_RS05040	COG0508	dehydrogenase complex catalyzes the overall conversion of
XA18_RS05045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XA18_RS05050	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XA18_RS05060	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XA18_RS05065	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XA18_RS05070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XA18_RS05075	COG0126	phosphoglycerate kinase activity
XA18_RS05080	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
XA18_RS05085	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
XA18_RS05100	COG0625	glutathione transferase activity
XA18_RS05130	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
XA18_RS05140	COG0521	Mo-molybdopterin cofactor biosynthetic process
XA18_RS05150	COG0739	heme binding
XA18_RS05160	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
XA18_RS05195	COG0745	RESPONSE REGULATOR receiver
XA18_RS05210	COG0840	transmembrane signaling receptor activity
XA18_RS05220	COG2201	protein-glutamate methylesterase activity
XA18_RS05225	COG0745	RESPONSE REGULATOR receiver
XA18_RS05230	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
XA18_RS05255	COG0667	Aldo Keto reductase
XA18_RS05265	COG4535	Mg2 and Co2 transporter CorC
XA18_RS05270	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XA18_RS05275	COG1702	phosphate starvation-inducible protein PhoH
XA18_RS05280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XA18_RS05295	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XA18_RS05300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XA18_RS05305	COG1862	Preprotein translocase
XA18_RS05310	COG0343	queuine tRNA-ribosyltransferase activity
XA18_RS05315	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XA18_RS05320	COG2027	D-alanyl-D-alanine carboxypeptidase
XA18_RS05325	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
XA18_RS05355	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XA18_RS05355	COG1648	precorrin-2 dehydrogenase activity
XA18_RS05380	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
XA18_RS05385	COG0741	lytic transglycosylase activity
XA18_RS05390	COG0436	Aminotransferase
XA18_RS05400	COG0280	phosphate acetyltransferase
XA18_RS05400	COG0281	malic enzyme
XA18_RS05410	COG2732	(Barnase) inhibitor
XA18_RS05425	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XA18_RS05450	COG0248	Ppx GppA phosphatase
XA18_RS05460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XA18_RS05470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
XA18_RS05475	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
XA18_RS05480	COG1534	Rna-binding protein
XA18_RS05510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XA18_RS05525	COG1295	ribonuclease BN
XA18_RS05535	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
XA18_RS05540	COG0745	RESPONSE REGULATOR receiver
XA18_RS05545	COG2205	protein histidine kinase activity
XA18_RS05580	COG1022	Amp-dependent synthetase and ligase
XA18_RS05595	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XA18_RS05600	COG1028	Short-chain dehydrogenase reductase Sdr
XA18_RS05610	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XA18_RS05625	COG1136	(ABC) transporter
XA18_RS05630	COG0084	hydrolase, TatD family'
XA18_RS05655	COG0658	competence protein
XA18_RS05655	COG2333	competence protein COMEC
XA18_RS05665	COG0613	PHP domain protein
XA18_RS05685	COG3539	Fimbrial protein
XA18_RS05690	COG0280	phosphate acetyltransferase
XA18_RS05690	COG0281	malic enzyme
XA18_RS05700	COG1522	sequence-specific DNA binding
XA18_RS05710	COG0567	Dehydrogenase, E1 component
XA18_RS05715	COG0508	dehydrogenase complex catalyzes the overall conversion of
XA18_RS05720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XA18_RS05725	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XA18_RS05730	COG1028	Short-chain dehydrogenase reductase Sdr
XA18_RS05735	COG0583	DNA-binding transcription factor activity
XA18_RS05745	COG3181	Tripartite tricarboxylate transporter family receptor
XA18_RS05770	COG0180	Tryptophanyl-tRNA synthetase
XA18_RS05775	COG2183	response to ionizing radiation
XA18_RS05780	COG1199	ATP-dependent helicase activity
XA18_RS05790	COG0564	pseudouridine synthase activity
XA18_RS05800	COG3243	poly(R)-hydroxyalkanoic acid synthase
XA18_RS05805	COG1028	Short-chain dehydrogenase reductase Sdr
XA18_RS05810	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
XA18_RS05825	COG0672	)-iron permease
XA18_RS05865	COG0583	DNA-binding transcription factor activity
XA18_RS05875	COG2814	Major facilitator Superfamily
XA18_RS05890	COG1619	proteins homologs of microcin C7 resistance protein MccF
XA18_RS05905	COG2084	Dehydrogenase
XA18_RS05910	COG3181	Tripartite tricarboxylate transporter family receptor
XA18_RS05935	COG2988	succinylglutamate desuccinylase activity
XA18_RS05960	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
XA18_RS05965	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
XA18_RS05965	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
XA18_RS05970	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
XA18_RS05975	COG0047	phosphoribosylformylglycinamidine synthase activity
XA18_RS05975	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XA18_RS05980	COG3064	Membrane
XA18_RS05980	COG3210	domain, Protein
XA18_RS05980	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
XA18_RS06010	COG0235	Class ii aldolase
XA18_RS06015	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
XA18_RS06020	COG0720	synthase
XA18_RS06025	COG0602	queuosine metabolic process
XA18_RS06050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XA18_RS06085	COG3181	Tripartite tricarboxylate transporter family receptor
XA18_RS06110	COG3842	ATPase activity
XA18_RS06120	COG0395	ABC-type sugar transport system, permease component
XA18_RS06150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XA18_RS06155	COG0420	3'-5' exonuclease activity
XA18_RS06200	COG0519	Catalyzes the synthesis of GMP from XMP
XA18_RS06200	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XA18_RS06215	COG3550	peptidyl-serine autophosphorylation
XA18_RS06225	COG0477	Major facilitator Superfamily
XA18_RS06240	COG1228	amidohydrolase
XA18_RS06250	COG1116	anion transmembrane transporter activity
XA18_RS06255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XA18_RS06290	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XA18_RS06305	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
XA18_RS06335	COG2814	Major facilitator Superfamily
XA18_RS06350	COG1280	lysine exporter protein (LysE YggA)
XA18_RS06365	COG0747	negative chemotaxis
XA18_RS06370	COG0601	transmembrane transport
XA18_RS06375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XA18_RS06380	COG4172	Belongs to the ABC transporter superfamily
XA18_RS06385	COG1609	Transcriptional regulator
XA18_RS06415	COG0586	Pfam SNARE associated Golgi protein
XA18_RS06430	COG0500	methyltransferase
XA18_RS06445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XA18_RS06455	COG0756	dUTP diphosphatase activity
XA18_RS06470	COG0291	Belongs to the bacterial ribosomal protein bL35 family
XA18_RS06475	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
XA18_RS06480	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
XA18_RS06485	COG0072	phenylalanine-tRNA ligase activity
XA18_RS06485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XA18_RS06490	COG0776	regulation of translation
XA18_RS06555	COG0540	Belongs to the ATCase OTCase family
XA18_RS06560	COG2974	May be involved in recombination
XA18_RS06570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
XA18_RS06575	COG0583	DNA-binding transcription factor activity
XA18_RS06595	COG1028	Short-chain dehydrogenase reductase Sdr
XA18_RS06610	COG3842	ATPase activity
XA18_RS06615	COG1250	3-hydroxyacyl-CoA dehydrogenase
XA18_RS06615	COG1024	Enoyl-CoA hydratase
XA18_RS06635	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XA18_RS06640	COG2137	regulation of response to DNA damage stimulus
XA18_RS06650	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
XA18_RS06660	COG0045	succinate-CoA ligase (ADP-forming) activity
XA18_RS06665	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XA18_RS06670	COG0861	Integral membrane protein TerC family
XA18_RS06675	COG0861	Integral membrane protein TerC family
XA18_RS06680	COG0181	hydroxymethylbilane synthase activity
XA18_RS06740	COG4964	Belongs to the GSP D family
XA18_RS06765	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XA18_RS06775	COG0583	DNA-binding transcription factor activity
XA18_RS06785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XA18_RS06790	COG4311	Sarcosine oxidase, delta subunit
XA18_RS06795	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XA18_RS06795	COG0446	pyridine nucleotide-disulphide oxidoreductase
XA18_RS06830	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XA18_RS06835	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XA18_RS06840	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XA18_RS06845	COG0735	belongs to the Fur family
XA18_RS06850	COG0497	DNA recombination
XA18_RS06855	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XA18_RS06860	COG1420	regulation of RNA biosynthetic process
XA18_RS06865	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XA18_RS06875	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XA18_RS06885	COG0443	Heat shock 70 kDa protein
XA18_RS06895	COG0612	Peptidase, M16
XA18_RS06915	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
XA18_RS06960	COG0745	RESPONSE REGULATOR receiver
XA18_RS06970	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
XA18_RS06975	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
XA18_RS06980	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
XA18_RS06995	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XA18_RS07015	COG1193	negative regulation of DNA recombination
XA18_RS07020	COG0492	ferredoxin-NADP+ reductase activity
XA18_RS07025	COG1674	ftsk spoiiie
XA18_RS07030	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XA18_RS07035	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XA18_RS07040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XA18_RS07065	COG3706	GGDEF domain
XA18_RS07085	COG2814	Major facilitator Superfamily
XA18_RS07115	COG3486	L-lysine 6-monooxygenase (NADPH) activity
XA18_RS07130	COG1028	Short-chain dehydrogenase reductase Sdr
XA18_RS07140	COG3022	response to hydroperoxide
XA18_RS07180	COG2197	response regulator
XA18_RS07185	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XA18_RS07190	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XA18_RS07195	COG0189	ligase activity
XA18_RS07205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XA18_RS07210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XA18_RS07225	COG2423	ornithine cyclodeaminase activity
XA18_RS07235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XA18_RS07240	COG0765	amino acid transport
XA18_RS07245	COG0765	amino acid transport
XA18_RS07250	COG1126	abc transporter atp-binding protein
XA18_RS07305	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XA18_RS07315	COG2944	sequence-specific DNA binding
XA18_RS07325	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XA18_RS07330	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
XA18_RS07335	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
XA18_RS07340	COG0009	L-threonylcarbamoyladenylate synthase
XA18_RS07345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XA18_RS07350	COG1414	Transcriptional regulator
XA18_RS07365	COG0765	amino acid transport
XA18_RS07370	COG1126	abc transporter atp-binding protein
XA18_RS07375	COG0028	Belongs to the TPP enzyme family
XA18_RS07390	COG0028	Belongs to the TPP enzyme family
XA18_RS07395	COG0583	DNA-binding transcription factor activity
XA18_RS07400	COG4974	Belongs to the 'phage' integrase family
XA18_RS07405	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
XA18_RS07410	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
XA18_RS07425	COG1686	Belongs to the peptidase S11 family
XA18_RS07435	COG2814	Major facilitator Superfamily
XA18_RS07445	COG1074	ATP-dependent DNA helicase activity
XA18_RS07455	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
XA18_RS07460	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XA18_RS07465	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XA18_RS07485	COG2321	neutral zinc metallopeptidase
XA18_RS07490	COG0009	L-threonylcarbamoyladenylate synthase
XA18_RS07535	COG3360	Dodecin
XA18_RS07540	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XA18_RS07545	COG2850	peptidyl-arginine hydroxylation
XA18_RS07550	COG3539	Fimbrial protein
XA18_RS07555	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
XA18_RS07560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XA18_RS07575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XA18_RS07580	COG0765	amino acid transport
XA18_RS07585	COG1126	abc transporter atp-binding protein
XA18_RS07590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XA18_RS07595	COG1758	RNA polymerase activity
XA18_RS07600	COG0194	GDP metabolic process
XA18_RS07605	COG3258	Cytochrome c
XA18_RS07610	COG2863	cytochrome
XA18_RS07615	COG1028	Short-chain dehydrogenase reductase Sdr
XA18_RS07620	COG0791	NLP P60 protein
XA18_RS07625	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
XA18_RS07645	COG1561	YicC-like family, N-terminal region
XA18_RS07650	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XA18_RS07665	COG0840	transmembrane signaling receptor activity
XA18_RS07670	COG2200	EAL domain
XA18_RS07670	COG2199	diguanylate cyclase activity
XA18_RS07675	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XA18_RS07685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XA18_RS07690	COG0174	glutamine synthetase
XA18_RS07700	COG2204	response regulator
XA18_RS07705	COG0583	DNA-binding transcription factor activity
XA18_RS07710	COG1741	Belongs to the pirin family
XA18_RS07715	COG1741	Belongs to the pirin family
XA18_RS07725	COG3842	ATPase activity
XA18_RS07730	COG1178	ABC-type Fe3 transport system permease component
XA18_RS07735	COG1840	ABC-type Fe3 transport system, periplasmic component
XA18_RS07745	COG0583	DNA-binding transcription factor activity
XA18_RS07755	COG0656	L-ascorbic acid biosynthetic process
XA18_RS07770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XA18_RS07775	COG0583	DNA-binding transcription factor activity
XA18_RS07790	COG0783	Belongs to the Dps family
XA18_RS07810	COG0463	Glycosyl transferase, family 2
XA18_RS07830	COG0438	transferase activity, transferring glycosyl groups
XA18_RS07845	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XA18_RS07870	COG0300	oxidoreductase activity
XA18_RS07915	COG0861	Integral membrane protein TerC family
XA18_RS07920	COG1028	Short-chain dehydrogenase reductase Sdr
XA18_RS07940	COG0714	Associated with various cellular activities
XA18_RS07975	COG3119	arylsulfatase activity
XA18_RS08000	COG2197	response regulator
XA18_RS08010	COG2944	sequence-specific DNA binding
XA18_RS08020	COG0625	glutathione transferase activity
XA18_RS08050	COG0179	Fumarylacetoacetate (FAA) hydrolase
XA18_RS08055	COG1028	Short-chain dehydrogenase reductase Sdr
XA18_RS08100	COG0431	NADPH-dependent FMN reductase
XA18_RS08130	COG1028	Short-chain dehydrogenase reductase Sdr
XA18_RS08135	COG0583	DNA-binding transcription factor activity
XA18_RS08155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XA18_RS08155	COG2111	Na H antiporter
XA18_RS08160	COG1006	Multisubunit Na H antiporter MnhC subunit
XA18_RS08165	COG0651	ATP synthesis coupled electron transport
XA18_RS08170	COG1863	multisubunit Na H antiporter MnhE subunit
XA18_RS08175	COG2212	antiporter activity
XA18_RS08200	COG0590	tRNA wobble adenosine to inosine editing
XA18_RS08205	COG1619	proteins homologs of microcin C7 resistance protein MccF
XA18_RS08210	COG1024	Enoyl-CoA hydratase
XA18_RS08225	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
XA18_RS08230	COG0488	(ABC) transporter
XA18_RS08265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
XA18_RS08265	COG1017	nitric oxide dioxygenase activity
XA18_RS08270	COG1959	2 iron, 2 sulfur cluster binding
XA18_RS08275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XA18_RS08295	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XA18_RS08300	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
XA18_RS08305	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
XA18_RS08310	COG0084	hydrolase, TatD family'
XA18_RS08325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XA18_RS08335	COG1126	abc transporter atp-binding protein
XA18_RS08345	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
XA18_RS08360	COG0028	Belongs to the TPP enzyme family
XA18_RS08370	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
XA18_RS08370	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
XA18_RS08380	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
XA18_RS08430	COG4336	lyase activity
XA18_RS08440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XA18_RS08440	COG2205	protein histidine kinase activity
XA18_RS08445	COG2197	response regulator
XA18_RS08465	COG3121	Chaperone
XA18_RS08470	COG3188	usher protein
XA18_RS08475	COG3539	Fimbrial protein
XA18_RS08480	COG2831	hemolysin activation secretion protein
XA18_RS08495	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
XA18_RS08545	COG0668	transmembrane transport
XA18_RS08565	COG0483	inositol monophosphate 1-phosphatase activity
XA18_RS08570	COG1253	flavin adenine dinucleotide binding
XA18_RS08575	COG1968	undecaprenyl-diphosphatase activity
XA18_RS08580	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XA18_RS08595	COG0215	cysteine-tRNA ligase activity
XA18_RS08605	COG0825	malonyl-CoA metabolic process
XA18_RS08615	COG0037	tRNA processing
XA18_RS08620	COG0527	aspartate kinase activity
XA18_RS08645	COG1250	3-hydroxyacyl-CoA dehydrogenase
XA18_RS08650	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
XA18_RS08650	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
XA18_RS08665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XA18_RS08670	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
XA18_RS08675	COG1028	Short-chain dehydrogenase reductase Sdr
XA18_RS08685	COG0583	DNA-binding transcription factor activity
XA18_RS08710	COG3842	ATPase activity
XA18_RS08720	COG0446	pyridine nucleotide-disulphide oxidoreductase
XA18_RS08720	COG1902	pentaerythritol trinitrate reductase activity
XA18_RS08725	COG1414	Transcriptional regulator
XA18_RS08730	COG1832	CoA-binding protein
XA18_RS08740	COG0251	oxidation-reduction process
XA18_RS08765	COG1902	pentaerythritol trinitrate reductase activity
XA18_RS08775	COG1215	transferase activity, transferring glycosyl groups
XA18_RS08780	COG1649	PFAM Uncharacterised BCR, COG1649
XA18_RS08780	COG0726	polysaccharide deacetylase
XA18_RS08800	COG1846	Transcriptional regulator
XA18_RS08815	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XA18_RS08825	COG0556	nucleotide-excision repair
XA18_RS08830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XA18_RS08840	COG1104	cysteine desulfurase activity
XA18_RS08845	COG0822	iron-sulfur transferase activity
XA18_RS08850	COG0316	Belongs to the HesB IscA family
XA18_RS08855	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XA18_RS08860	COG0443	Heat shock 70 kDa protein
XA18_RS08865	COG0633	Ferredoxin
XA18_RS08885	COG1024	Enoyl-CoA hydratase
XA18_RS08900	COG3395	kinase activity
XA18_RS08920	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
XA18_RS08930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XA18_RS08955	COG0747	negative chemotaxis
XA18_RS08960	COG0601	transmembrane transport
XA18_RS08965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XA18_RS08970	COG4172	Belongs to the ABC transporter superfamily
XA18_RS08975	COG0154	amidase activity
XA18_RS09020	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XA18_RS09025	COG0425	Belongs to the sulfur carrier protein TusA family
XA18_RS09035	COG0228	four-way junction DNA binding
XA18_RS09040	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XA18_RS09045	COG0336	Belongs to the RNA methyltransferase TrmD family
XA18_RS09050	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XA18_RS09075	COG0642	Histidine kinase
XA18_RS09090	COG0525	valine-tRNA ligase activity
XA18_RS09095	COG0105	UTP biosynthetic process
XA18_RS09100	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XA18_RS09110	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XA18_RS09115	COG0124	histidyl-tRNA synthetase
XA18_RS09120	COG2976	Protein conserved in bacteria
XA18_RS09125	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XA18_RS09130	COG1160	GTP binding
XA18_RS09135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XA18_RS09140	COG1923	regulation of RNA biosynthetic process
XA18_RS09145	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XA18_RS09150	COG0330	HflC and HflK could
XA18_RS09155	COG0330	HflC and HflK could
XA18_RS09160	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
XA18_RS09165	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XA18_RS09170	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
XA18_RS09175	COG0828	Belongs to the bacterial ribosomal protein bS21 family
XA18_RS09185	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XA18_RS09220	COG0628	permease
XA18_RS09225	COG0842	Transport permease protein
XA18_RS09230	COG1131	(ABC) transporter
XA18_RS09300	COG0156	8-amino-7-oxononanoate synthase activity
XA18_RS09310	COG4106	trans-aconitate 2-methyltransferase activity
XA18_RS09310	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XA18_RS09315	COG1380	Effector of murein hydrolase LrgA
XA18_RS09335	COG3284	Transcriptional regulator
XA18_RS09340	COG1012	belongs to the aldehyde dehydrogenase family
XA18_RS09355	COG2733	membrane
XA18_RS09360	COG0583	DNA-binding transcription factor activity
XA18_RS09365	COG0384	phenazine biosynthesis protein PhzF
XA18_RS09370	COG5507	3-demethylubiquinone-9 3-methyltransferase
XA18_RS09375	COG2169	Transcriptional regulator
XA18_RS09405	COG0659	secondary active sulfate transmembrane transporter activity
XA18_RS09430	COG1132	(ABC) transporter
XA18_RS09480	COG2207	Transcriptional regulator
XA18_RS09620	COG2346	COG2346, Truncated hemoglobins
XA18_RS09650	COG0583	DNA-binding transcription factor activity
XA18_RS09665	COG0183	Belongs to the thiolase family
XA18_RS09680	COG1804	L-carnitine dehydratase bile acid-inducible protein F
XA18_RS09685	COG0633	Ferredoxin
XA18_RS09695	COG1024	Enoyl-CoA hydratase
XA18_RS09705	COG4638	Rieske (2fe-2S)
XA18_RS09715	COG0559	Belongs to the binding-protein-dependent transport system permease family
XA18_RS09735	COG2224	Isocitrate lyase
XA18_RS09740	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XA18_RS09740	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XA18_RS09750	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XA18_RS09755	COG0322	excinuclease ABC activity
XA18_RS09760	COG1472	Belongs to the glycosyl hydrolase 3 family
XA18_RS09765	COG0736	holo-[acyl-carrier-protein] synthase activity
XA18_RS09770	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XA18_RS09780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XA18_RS09785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XA18_RS09810	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
XA18_RS09825	COG2032	superoxide dismutase activity
XA18_RS09840	COG1024	Enoyl-CoA hydratase
XA18_RS09850	COG1802	Transcriptional regulator
XA18_RS09860	COG0183	Belongs to the thiolase family
XA18_RS09865	COG1942	4-Oxalocrotonate Tautomerase
XA18_RS09875	COG4176	ABC-type proline glycine betaine transport system permease component
XA18_RS09895	COG2814	Major facilitator Superfamily
XA18_RS09900	COG0227	Belongs to the bacterial ribosomal protein bL28 family
XA18_RS09905	COG0267	Belongs to the bacterial ribosomal protein bL33 family
XA18_RS09940	COG2814	Major facilitator Superfamily
XA18_RS09945	COG0495	leucyl-tRNA aminoacylation
XA18_RS09960	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XA18_RS09970	COG0154	amidase activity
XA18_RS09975	COG1250	3-hydroxyacyl-CoA dehydrogenase
XA18_RS10030	COG0427	acetyl-CoA hydrolase
XA18_RS10035	COG0583	DNA-binding transcription factor activity
XA18_RS10055	COG0730	response to heat
XA18_RS10060	COG0697	spore germination
XA18_RS10095	COG2885	chlorophyll binding
XA18_RS10125	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
XA18_RS10130	COG3384	dioxygenase
XA18_RS10145	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XA18_RS10150	COG3474	cytochrome
XA18_RS10160	COG1595	DNA-templated transcription, initiation
XA18_RS10175	COG2204	response regulator
XA18_RS10215	COG4964	Belongs to the GSP D family
XA18_RS10270	COG1846	Transcriptional regulator
XA18_RS10275	COG4172	Belongs to the ABC transporter superfamily
XA18_RS10280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XA18_RS10285	COG0601	transmembrane transport
XA18_RS10290	COG0747	negative chemotaxis
XA18_RS10300	COG0598	Magnesium transport protein CorA
XA18_RS10305	COG0210	DNA helicase
XA18_RS10320	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
XA18_RS10325	COG1012	belongs to the aldehyde dehydrogenase family
XA18_RS10330	COG0483	inositol monophosphate 1-phosphatase activity
XA18_RS10335	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
XA18_RS10345	COG1045	serine acetyltransferase
XA18_RS10350	COG0166	Belongs to the GPI family
XA18_RS10365	COG2197	response regulator
XA18_RS10385	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
XA18_RS10405	COG1028	Short-chain dehydrogenase reductase Sdr
XA18_RS10410	COG0183	Belongs to the thiolase family
XA18_RS10420	COG1024	Enoyl-CoA hydratase
XA18_RS10435	COG1804	L-carnitine dehydratase bile acid-inducible protein F
XA18_RS10440	COG0583	DNA-binding transcription factor activity
XA18_RS10445	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
XA18_RS10450	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XA18_RS10455	COG0740	serine-type endopeptidase activity
XA18_RS10460	COG0544	peptidyl-prolyl cis-trans isomerase activity
XA18_RS10470	COG1278	Cold shock
XA18_RS10480	COG1278	Cold shock
XA18_RS10515	COG2171	N-acyltransferase activity
XA18_RS10520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XA18_RS10525	COG2890	protein-(glutamine-N5) methyltransferase activity
XA18_RS10530	COG0488	(ABC) transporter
XA18_RS10535	COG4771	TonB-dependent receptor
XA18_RS10540	COG0210	DNA helicase
XA18_RS10560	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XA18_RS10565	COG0196	riboflavin kinase activity
XA18_RS10570	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
XA18_RS10575	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XA18_RS10580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XA18_RS10590	COG1522	sequence-specific DNA binding
XA18_RS10610	COG2951	lytic endotransglycosylase activity
XA18_RS10615	COG2833	Protein of unknown function (DUF455)
XA18_RS10635	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XA18_RS10635	COG0189	ligase activity
XA18_RS10640	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XA18_RS10640	COG1181	Belongs to the D-alanine--D-alanine ligase family
XA18_RS10645	COG3237	CsbD-like
XA18_RS10655	COG2823	Periplasmic or secreted lipoprotein
XA18_RS10670	COG4181	ATPase activity
XA18_RS10680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XA18_RS10685	COG0584	glycerophosphoryl diester phosphodiesterase
XA18_RS10690	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XA18_RS10700	COG0678	peroxiredoxin activity
XA18_RS10700	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
XA18_RS10710	COG0789	Transcriptional regulator
XA18_RS10715	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XA18_RS10745	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XA18_RS10750	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
XA18_RS10760	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XA18_RS10765	COG2252	PERMEase
XA18_RS10775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XA18_RS10810	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
XA18_RS10815	COG2358	TRAP transporter, solute receptor (TAXI family
XA18_RS10855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XA18_RS10860	COG1366	Belongs to the anti-sigma-factor antagonist family
XA18_RS10865	COG2172	sigma factor antagonist activity
XA18_RS10870	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XA18_RS10880	COG2208	phosphoserine phosphatase activity
XA18_RS10880	COG2770	Histidine kinase
XA18_RS10900	COG1595	DNA-templated transcription, initiation
XA18_RS10915	COG4792	protein secretion
XA18_RS10920	COG4791	protein targeting
XA18_RS10925	COG4794	Type iii secretion
XA18_RS10930	COG4790	Type iii secretion
XA18_RS10965	COG4669	(LipO)protein
XA18_RS11030	COG4789	Type iii secretion
XA18_RS11060	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XA18_RS11065	COG0840	transmembrane signaling receptor activity
XA18_RS11070	COG2233	PERMEase
XA18_RS11095	COG1840	ABC-type Fe3 transport system, periplasmic component
XA18_RS11100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XA18_RS11105	COG1178	ABC-type Fe3 transport system permease component
XA18_RS11110	COG3842	ATPase activity
XA18_RS11115	COG0583	DNA-binding transcription factor activity
XA18_RS11135	COG0501	Belongs to the peptidase M48B family
XA18_RS11145	COG0697	spore germination
XA18_RS11155	COG1846	Transcriptional regulator
XA18_RS11165	COG1566	PFAM secretion protein HlyD family protein
XA18_RS11170	COG2814	Major facilitator Superfamily
XA18_RS11175	COG0473	3-isopropylmalate dehydrogenase activity
XA18_RS11185	COG0747	negative chemotaxis
XA18_RS11195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XA18_RS11210	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
XA18_RS11235	COG1012	belongs to the aldehyde dehydrogenase family
XA18_RS11245	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
XA18_RS11250	COG1115	amino acid carrier protein
XA18_RS11255	COG0433	COG0433 Predicted ATPase
XA18_RS11260	COG0217	transcriptional regulatory protein
XA18_RS11265	COG0151	Belongs to the GarS family
XA18_RS11270	COG0408	coproporphyrinogen oxidase activity
XA18_RS11275	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XA18_RS11280	COG0799	negative regulation of ribosome biogenesis
XA18_RS11285	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XA18_RS11290	COG0424	maF-like protein
XA18_RS11295	COG3468	outer membrane autotransporter barrel domain protein
XA18_RS11335	COG1530	ribonuclease E activity
XA18_RS11340	COG0077	Prephenate dehydratase
XA18_RS11355	COG1132	(ABC) transporter
XA18_RS11360	COG0859	PFAM glycosyl transferase family 9
XA18_RS11385	COG2194	sulfuric ester hydrolase activity
XA18_RS11390	COG0438	transferase activity, transferring glycosyl groups
XA18_RS11395	COG0463	Glycosyl transferase, family 2
XA18_RS11400	COG0726	polysaccharide deacetylase
XA18_RS11405	COG0438	transferase activity, transferring glycosyl groups
XA18_RS11420	COG1643	Atp-dependent helicase
XA18_RS11425	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
XA18_RS11425	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XA18_RS11430	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XA18_RS11440	COG0704	Plays a role in the regulation of phosphate uptake
XA18_RS11445	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XA18_RS11450	COG1960	acyl-CoA dehydrogenase activity
XA18_RS11475	COG1177	transmembrane transport
XA18_RS11480	COG1176	ABC-type spermidine putrescine transport system, permease component I
XA18_RS11485	COG3842	ATPase activity
XA18_RS11490	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
XA18_RS11505	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
XA18_RS11510	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
XA18_RS11520	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
XA18_RS11520	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
XA18_RS11535	COG0372	Belongs to the citrate synthase family
XA18_RS11540	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XA18_RS11545	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XA18_RS11550	COG1053	succinate dehydrogenase
XA18_RS11555	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XA18_RS11560	COG2009	succinate dehydrogenase
XA18_RS11565	COG2188	Transcriptional regulator
XA18_RS11570	COG0039	L-malate dehydrogenase activity
XA18_RS11600	COG1981	membrane
XA18_RS11625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XA18_RS11635	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XA18_RS11665	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
XA18_RS11670	COG0148	phosphopyruvate hydratase activity
XA18_RS11680	COG2877	3-deoxy-8-phosphooctulonate synthase activity
XA18_RS11685	COG0504	CTP synthase activity
XA18_RS11710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XA18_RS11720	COG0747	negative chemotaxis
XA18_RS11725	COG4172	Belongs to the ABC transporter superfamily
XA18_RS11730	COG1446	asparaginase
XA18_RS11760	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
XA18_RS11775	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
XA18_RS11780	COG0697	spore germination
XA18_RS11785	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XA18_RS11795	COG3193	protein, possibly involved in utilization of glycolate and propanediol
XA18_RS11805	COG0791	NLP P60 protein
XA18_RS11830	COG0583	DNA-binding transcription factor activity
XA18_RS11845	COG0583	DNA-binding transcription factor activity
XA18_RS11855	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XA18_RS11870	COG0670	Belongs to the BI1 family
XA18_RS11875	COG3181	Tripartite tricarboxylate transporter family receptor
XA18_RS11890	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
XA18_RS11900	COG1381	Involved in DNA repair and RecF pathway recombination
XA18_RS11905	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XA18_RS11910	COG0571	ribonuclease III activity
XA18_RS11915	COG0681	Belongs to the peptidase S26 family
XA18_RS11920	COG0481	GTPase activity
XA18_RS11925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XA18_RS11950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XA18_RS11955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XA18_RS11970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XA18_RS11975	COG0416	fatty acid biosynthetic process
XA18_RS11980	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XA18_RS11985	COG1399	metal-binding, possibly nucleic acid-binding protein
XA18_RS11990	COG0424	maF-like protein
XA18_RS12000	COG3023	N-Acetylmuramoyl-L-alanine amidase
XA18_RS12015	COG3022	response to hydroperoxide
XA18_RS12030	COG0135	phosphoribosylanthranilate isomerase activity
XA18_RS12045	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
XA18_RS12050	COG0101	tRNA pseudouridine synthase activity
XA18_RS12060	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XA18_RS12065	COG0473	3-isopropylmalate dehydrogenase activity
XA18_RS12070	COG0066	3-isopropylmalate dehydratase activity
XA18_RS12075	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XA18_RS12085	COG1122	ATPase activity
XA18_RS12120	COG0243	molybdopterin cofactor binding
XA18_RS12120	COG3383	formate dehydrogenase (NAD+) activity
XA18_RS12150	COG0489	protein tyrosine kinase activity
XA18_RS12155	COG0746	molybdenum cofactor guanylyltransferase activity
XA18_RS12160	COG0303	'Molybdopterin
XA18_RS12165	COG1763	Mo-molybdopterin cofactor biosynthetic process
XA18_RS12175	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XA18_RS12180	COG5001	Diguanylate cyclase
XA18_RS12200	COG3842	ATPase activity
XA18_RS12210	COG0406	alpha-ribazole phosphatase activity
XA18_RS12220	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XA18_RS12225	COG0505	Belongs to the CarA family
XA18_RS12230	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
XA18_RS12265	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
XA18_RS12270	COG1960	acyl-CoA dehydrogenase activity
XA18_RS12280	COG2867	negative regulation of translational initiation
XA18_RS12290	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XA18_RS12295	COG3706	GGDEF domain
XA18_RS12300	COG0330	HflC and HflK could
XA18_RS12315	COG0519	Catalyzes the synthesis of GMP from XMP
XA18_RS12315	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XA18_RS12325	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XA18_RS12330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XA18_RS12335	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
XA18_RS12340	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XA18_RS12350	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XA18_RS12355	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XA18_RS12360	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
XA18_RS12365	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XA18_RS12370	COG0750	zinc metalloprotease
XA18_RS12375	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XA18_RS12385	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XA18_RS12390	COG0233	cytoplasmic translational termination
XA18_RS12395	COG0528	UMP kinase activity
XA18_RS12400	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XA18_RS12405	COG0052	Belongs to the universal ribosomal protein uS2 family
XA18_RS12410	COG0024	Methionine aminopeptidase
XA18_RS12415	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
XA18_RS12445	COG0285	dihydrofolate synthase activity
XA18_RS12480	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XA18_RS12490	COG1677	Flagellar hook-basal body complex protein FliE
XA18_RS12500	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
XA18_RS12505	COG1317	bacterial-type flagellum organization
XA18_RS12510	COG1157	protein secretion by the type III secretion system
XA18_RS12535	COG1580	Controls the rotational direction of flagella during chemotaxis
XA18_RS12555	COG1338	Plays a role in the flagellum-specific transport system
XA18_RS12575	COG0840	transmembrane signaling receptor activity
XA18_RS12580	COG0840	transmembrane signaling receptor activity
XA18_RS12585	COG0840	transmembrane signaling receptor activity
XA18_RS12595	COG1256	bacterial-type flagellum assembly
XA18_RS12605	COG1706	bacterial-type flagellum-dependent cell motility
XA18_RS12610	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
XA18_RS12625	COG1749	Flagellar hook protein flgE
XA18_RS12635	COG1558	bacterial-type flagellum-dependent cell motility
XA18_RS12640	COG1815	bacterial-type flagellum-dependent cell motility
XA18_RS12680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XA18_RS12685	COG0765	amino acid transport
XA18_RS12690	COG1126	abc transporter atp-binding protein
XA18_RS12705	COG4948	Mandelate Racemase Muconate Lactonizing
XA18_RS12710	COG3181	Tripartite tricarboxylate transporter family receptor
XA18_RS12720	COG0066	3-isopropylmalate dehydratase activity
XA18_RS12735	COG1804	L-carnitine dehydratase bile acid-inducible protein F
XA18_RS12745	COG3181	Tripartite tricarboxylate transporter family receptor
XA18_RS12755	COG1802	Transcriptional regulator
XA18_RS12770	COG0583	DNA-binding transcription factor activity
XA18_RS12790	COG1695	Transcriptional regulator
XA18_RS12800	COG3568	Endonuclease Exonuclease Phosphatase
XA18_RS12805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XA18_RS12855	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XA18_RS12865	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XA18_RS12885	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
XA18_RS12915	COG0667	Aldo Keto reductase
XA18_RS12930	COG2259	Doxx family
XA18_RS12970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
XA18_RS12990	COG0386	Belongs to the glutathione peroxidase family
XA18_RS12995	COG0625	glutathione transferase activity
XA18_RS13010	COG0095	Lipoate-protein ligase
XA18_RS13025	COG0688	phosphatidylethanolamine metabolic process
XA18_RS13035	COG1464	Belongs to the NlpA lipoprotein family
XA18_RS13050	COG2363	Small membrane protein
XA18_RS13085	COG3842	ATPase activity
XA18_RS13090	COG0395	ABC-type sugar transport system, permease component
XA18_RS13095	COG1175	transmembrane transport
XA18_RS13100	COG1653	transport
XA18_RS13110	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XA18_RS13125	COG0559	Belongs to the binding-protein-dependent transport system permease family
XA18_RS13145	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
XA18_RS13175	COG2311	Membrane
XA18_RS13200	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XA18_RS13210	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
XA18_RS13215	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XA18_RS13220	COG1760	l-serine dehydratase
XA18_RS13225	COG1283	sodium-dependent phosphate transmembrane transporter activity
XA18_RS13230	COG0412	Dienelactone hydrolase
XA18_RS13245	COG1611	Belongs to the LOG family
XA18_RS13265	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XA18_RS13270	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XA18_RS13275	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XA18_RS13280	COG0195	Participates in both transcription termination and antitermination
XA18_RS13280	COG2251	uridine kinase activity
XA18_RS13285	COG0779	Required for maturation of 30S ribosomal subunits
XA18_RS13290	COG1187	pseudouridine synthase activity
XA18_RS13295	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
XA18_RS13305	COG0583	DNA-binding transcription factor activity
XA18_RS13315	COG0523	cobalamin synthesis protein
XA18_RS13335	COG0625	glutathione transferase activity
XA18_RS13340	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
XA18_RS13345	COG1047	Peptidyl-prolyl cis-trans
XA18_RS13350	COG2003	Belongs to the UPF0758 family
XA18_RS13355	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
XA18_RS13360	COG3483	tryptophan 2,3-dioxygenase activity
XA18_RS13365	COG0254	rRNA binding
XA18_RS13375	COG0534	Mate efflux family protein
XA18_RS13395	COG2304	oxidoreductase activity
XA18_RS13415	COG1028	Short-chain dehydrogenase reductase Sdr
XA18_RS13420	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XA18_RS13425	COG1562	ergosterol biosynthetic process
XA18_RS13430	COG1562	ergosterol biosynthetic process
XA18_RS13435	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
XA18_RS13435	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
XA18_RS13440	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XA18_RS13450	COG0842	Transport permease protein
XA18_RS13455	COG1131	(ABC) transporter
XA18_RS13475	COG1477	protein flavinylation
XA18_RS13490	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
XA18_RS13505	COG5564	TIM-barrel signal transduction protein
XA18_RS13510	COG5441	Belongs to the UPF0261 family
XA18_RS13520	COG3468	outer membrane autotransporter barrel domain protein
XA18_RS13540	COG0542	response to heat
XA18_RS13545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XA18_RS13560	COG0494	nUDIX hydrolase
XA18_RS13565	COG3530	Putative quorum-sensing-regulated virulence factor
XA18_RS13575	COG1595	DNA-templated transcription, initiation
XA18_RS13580	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XA18_RS13615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XA18_RS13620	COG0765	amino acid transport
XA18_RS13625	COG0765	amino acid transport
XA18_RS13655	COG3539	Fimbrial protein
XA18_RS13665	COG2050	protein possibly involved in aromatic compounds catabolism
XA18_RS13670	COG1024	Enoyl-CoA hydratase
XA18_RS13675	COG1012	belongs to the aldehyde dehydrogenase family
XA18_RS13695	COG2151	metal-sulfur cluster biosynthetic enzyme
XA18_RS13700	COG3396	Phenylacetate-CoA oxygenase
XA18_RS13705	COG3460	Phenylacetate-CoA oxygenase
XA18_RS13710	COG3396	Phenylacetate-CoA oxygenase
XA18_RS13715	COG3327	negative regulation of DNA-templated transcription, initiation
XA18_RS13725	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XA18_RS13730	COG0501	Belongs to the peptidase M48B family
XA18_RS13735	COG1162	GTPase activity
XA18_RS13750	COG0601	transmembrane transport
XA18_RS13755	COG0747	negative chemotaxis
XA18_RS13800	COG0668	transmembrane transport
XA18_RS13805	COG0165	Argininosuccinate lyase
XA18_RS13825	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
XA18_RS13830	COG0303	'Molybdopterin
XA18_RS13835	COG0521	Mo-molybdopterin cofactor biosynthetic process
XA18_RS13850	COG0315	cyclic pyranopterin monophosphate synthase activity
XA18_RS13860	COG0412	Dienelactone hydrolase
XA18_RS13870	COG0678	peroxiredoxin activity
XA18_RS13880	COG0697	spore germination
XA18_RS13885	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XA18_RS13910	COG0789	Transcriptional regulator
XA18_RS13930	COG1028	Short-chain dehydrogenase reductase Sdr
XA18_RS13940	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XA18_RS13945	COG1845	cytochrome c oxidase, subunit III
XA18_RS13950	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XA18_RS13960	COG0477	Major facilitator Superfamily
XA18_RS13995	COG1309	transcriptional regulator
XA18_RS14000	COG2271	Major facilitator Superfamily
XA18_RS14035	COG0506	proline dehydrogenase activity
XA18_RS14035	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
XA18_RS14035	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
XA18_RS14045	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XA18_RS14045	COG3008	intermembrane lipid transfer
XA18_RS14050	COG2995	paraquat-inducible protein a
XA18_RS14055	COG0542	response to heat
XA18_RS14060	COG4953	penicillin-binding protein 1C
XA18_RS14070	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
XA18_RS14075	COG1278	Cold shock
XA18_RS14085	COG0183	Belongs to the thiolase family
XA18_RS14090	COG0038	chloride channel
XA18_RS14095	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XA18_RS14100	COG1570	exodeoxyribonuclease VII activity
XA18_RS14110	COG0811	peptide transport
XA18_RS14115	COG0848	biopolymer transport protein
XA18_RS14120	COG1663	tetraacyldisaccharide 4'-kinase activity
XA18_RS14125	COG2835	tetraacyldisaccharide 4'-kinase activity
XA18_RS14130	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XA18_RS14135	COG0563	adenylate kinase activity
XA18_RS14145	COG0728	peptidoglycan biosynthetic process
XA18_RS14155	COG0268	Binds directly to 16S ribosomal RNA
XA18_RS14190	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
XA18_RS14215	COG0436	Aminotransferase
XA18_RS14220	COG3737	Protein of unknown function (DUF498/DUF598)
XA18_RS14225	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XA18_RS14230	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
XA18_RS14235	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XA18_RS14245	COG0305	Participates in initiation and elongation during chromosome replication
XA18_RS14255	COG0359	binds to the 23S rRNA
XA18_RS14260	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XA18_RS14265	COG2965	DNA replication, synthesis of RNA primer
XA18_RS14270	COG0360	Binds together with S18 to 16S ribosomal RNA
XA18_RS14275	COG1469	GTP cyclohydrolase I activity
XA18_RS14280	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XA18_RS14285	COG0142	geranyltranstransferase activity
XA18_RS14290	COG1722	exodeoxyribonuclease VII activity
XA18_RS14300	COG3181	Tripartite tricarboxylate transporter family receptor
XA18_RS14320	COG2239	Acts as a magnesium transporter
XA18_RS14330	COG2855	membrane
XA18_RS14340	COG1473	amidohydrolase
XA18_RS14345	COG0318	PFAM AMP-dependent synthetase and ligase
XA18_RS14370	COG1501	Belongs to the glycosyl hydrolase 31 family
XA18_RS14375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XA18_RS14380	COG2011	ABC-type metal ion transport system permease component
XA18_RS14400	COG1454	alcohol dehydrogenase
XA18_RS14430	COG2186	Transcriptional regulator
XA18_RS14435	COG3181	Tripartite tricarboxylate transporter family receptor
XA18_RS14455	COG1175	transmembrane transport
XA18_RS14460	COG0395	ABC-type sugar transport system, permease component
XA18_RS14465	COG3842	ATPase activity
XA18_RS14480	COG1653	transport
XA18_RS14500	COG2818	Glycosylase
XA18_RS14505	COG2982	Protein involved in outer membrane biogenesis
XA18_RS14515	COG1309	transcriptional regulator
XA18_RS14520	COG1028	Short-chain dehydrogenase reductase Sdr
XA18_RS14580	COG0583	DNA-binding transcription factor activity
XA18_RS14585	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XA18_RS14590	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
XA18_RS14605	COG1028	Short-chain dehydrogenase reductase Sdr
XA18_RS14610	COG0477	Major facilitator Superfamily
XA18_RS14620	COG0583	DNA-binding transcription factor activity
XA18_RS14625	COG1448	Aminotransferase
XA18_RS14630	COG1418	mRNA catabolic process
XA18_RS14655	COG1063	alcohol dehydrogenase
XA18_RS14675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XA18_RS14685	COG0318	PFAM AMP-dependent synthetase and ligase
XA18_RS14695	COG1522	sequence-specific DNA binding
XA18_RS14700	COG3181	Tripartite tricarboxylate transporter family receptor
XA18_RS14705	COG0307	riboflavin synthase, alpha
XA18_RS14710	COG0154	amidase activity
XA18_RS14730	COG2807	transmembrane transport
XA18_RS14735	COG0590	tRNA wobble adenosine to inosine editing
XA18_RS14745	COG0583	DNA-binding transcription factor activity
XA18_RS14780	COG0559	Belongs to the binding-protein-dependent transport system permease family
XA18_RS14785	COG0251	oxidation-reduction process
XA18_RS14790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XA18_RS14800	COG1414	Transcriptional regulator
XA18_RS14805	COG1028	Short-chain dehydrogenase reductase Sdr
XA18_RS14820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XA18_RS14835	COG1024	Enoyl-CoA hydratase
XA18_RS14840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
XA18_RS14845	COG0154	amidase activity
XA18_RS14885	COG3909	cytochrome
XA18_RS14890	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
XA18_RS14895	COG0625	glutathione transferase activity
XA18_RS14900	COG0730	response to heat
XA18_RS14905	COG0482	sulfurtransferase activity
XA18_RS14910	COG0583	DNA-binding transcription factor activity
XA18_RS14950	COG2819	hydrolase of the alpha beta superfamily
XA18_RS14955	COG0247	lactate metabolic process
XA18_RS14960	COG0277	FAD linked oxidase domain protein
XA18_RS14965	COG0277	FAD linked oxidase domain protein
XA18_RS14970	COG0277	FAD linked oxidase domain protein
XA18_RS14975	COG3064	Membrane
XA18_RS14975	COG3064	Membrane
XA18_RS14975	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
XA18_RS14975	COG3210	domain, Protein
XA18_RS14975	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
XA18_RS14975	COG3210	domain, Protein
XA18_RS14980	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XA18_RS14985	COG0312	modulator of DNA gyrase
XA18_RS15020	COG1666	GTP binding
XA18_RS15065	COG3220	belongs to the UPF0276 family
XA18_RS15085	COG0640	Transcriptional regulator
XA18_RS15090	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XA18_RS15095	COG1845	cytochrome c oxidase, subunit III
XA18_RS15100	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XA18_RS15110	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
XA18_RS15145	COG1804	L-carnitine dehydratase bile acid-inducible protein F
XA18_RS15150	COG0583	DNA-binding transcription factor activity
XA18_RS15185	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XA18_RS15185	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XA18_RS15200	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XA18_RS15205	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XA18_RS15215	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XA18_RS15230	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XA18_RS15235	COG0316	Belongs to the HesB IscA family
XA18_RS15245	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
XA18_RS15250	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XA18_RS15255	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
XA18_RS15260	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
XA18_RS15265	COG0312	modulator of DNA gyrase
XA18_RS15270	COG3028	Belongs to the UPF0307 family
XA18_RS15285	COG1116	anion transmembrane transporter activity
XA18_RS15290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XA18_RS15295	COG1335	isochorismatase
XA18_RS15300	COG0346	lactoylglutathione lyase activity
XA18_RS15305	COG0513	Belongs to the DEAD box helicase family
XA18_RS15310	COG3069	C4-dicarboxylate transmembrane transporter activity
XA18_RS15315	COG1802	Transcriptional regulator
XA18_RS15330	COG1042	CoA-binding domain protein
XA18_RS15330	COG0045	succinate-CoA ligase (ADP-forming) activity
XA18_RS15330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XA18_RS15335	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XA18_RS15350	COG1522	sequence-specific DNA binding
XA18_RS15385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XA18_RS15390	COG1696	Membrane protein involved in D-alanine export
XA18_RS15415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XA18_RS15430	COG0439	Biotin carboxylase
XA18_RS15435	COG0511	ligase activity, forming carbon-carbon bonds
XA18_RS15440	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XA18_RS15445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XA18_RS15450	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XA18_RS15455	COG3150	esterase
XA18_RS15460	COG0557	exoribonuclease II activity
XA18_RS15470	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XA18_RS15490	COG1522	sequence-specific DNA binding
XA18_RS15495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XA18_RS15500	COG1028	Short-chain dehydrogenase reductase Sdr
XA18_RS15520	COG0653	protein targeting
XA18_RS15525	COG0739	heme binding
XA18_RS15535	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XA18_RS15540	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
XA18_RS15550	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XA18_RS15555	COG1181	Belongs to the D-alanine--D-alanine ligase family
XA18_RS15560	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XA18_RS15565	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XA18_RS15575	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XA18_RS15580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XA18_RS15585	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XA18_RS15595	COG3116	cell division
XA18_RS15600	COG0275	rRNA processing
XA18_RS15605	COG2001	Belongs to the MraZ family
XA18_RS15615	COG0488	(ABC) transporter
XA18_RS15620	COG0418	dihydroorotase activity
XA18_RS15625	COG1473	amidohydrolase
XA18_RS15675	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XA18_RS15680	COG4654	Cytochrome c, class I
XA18_RS15685	COG0129	dihydroxy-acid dehydratase activity
XA18_RS15690	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XA18_RS15740	COG2084	Dehydrogenase
XA18_RS15760	COG2096	Adenosyltransferase
XA18_RS15775	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XA18_RS15780	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
XA18_RS15790	COG0523	cobalamin synthesis protein
XA18_RS15795	COG0735	belongs to the Fur family
XA18_RS15815	COG0803	Belongs to the bacterial solute-binding protein 9 family
XA18_RS15825	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
XA18_RS15835	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XA18_RS15845	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XA18_RS15850	COG1560	Kdo2-lipid A biosynthetic process
XA18_RS15860	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XA18_RS15875	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
XA18_RS15880	COG1950	PFAM Membrane protein of
XA18_RS15895	COG0583	DNA-binding transcription factor activity
XA18_RS15905	COG0477	Major facilitator Superfamily
XA18_RS15920	COG0617	tRNA 3'-terminal CCA addition
XA18_RS15930	COG0513	Belongs to the DEAD box helicase family
XA18_RS15935	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XA18_RS15945	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XA18_RS15950	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
XA18_RS16025	COG0405	Gamma-glutamyltransferase
XA18_RS16035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XA18_RS16065	COG1309	transcriptional regulator
XA18_RS16080	COG0745	RESPONSE REGULATOR receiver
XA18_RS16130	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XA18_RS16155	COG0582	viral genome integration into host DNA
XA18_RS16160	COG0012	GTP binding
XA18_RS16170	COG0193	aminoacyl-tRNA hydrolase activity
XA18_RS16175	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
XA18_RS16180	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XA18_RS16190	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XA18_RS16195	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XA18_RS16205	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XA18_RS16230	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
XA18_RS16240	COG1368	sulfuric ester hydrolase activity
XA18_RS16245	COG0642	Histidine kinase
XA18_RS16250	COG0745	RESPONSE REGULATOR receiver
XA18_RS16255	COG0277	FAD linked oxidase domain protein
XA18_RS16270	COG0166	Belongs to the GPI family
XA18_RS16275	COG0438	transferase activity, transferring glycosyl groups
XA18_RS16280	COG0438	transferase activity, transferring glycosyl groups
XA18_RS16295	COG0438	transferase activity, transferring glycosyl groups
XA18_RS16310	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XA18_RS16315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XA18_RS16320	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
XA18_RS16330	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XA18_RS16340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XA18_RS16345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
XA18_RS16355	COG0747	negative chemotaxis
XA18_RS16360	COG0601	transmembrane transport
XA18_RS16365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XA18_RS16385	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
XA18_RS16390	COG0830	nickel cation binding
XA18_RS16400	COG0804	urea catabolic process
XA18_RS16405	COG0832	Belongs to the urease beta subunit family
XA18_RS16415	COG0831	urea catabolic process
XA18_RS16420	COG0829	nickel cation binding
XA18_RS16445	COG2188	Transcriptional regulator
XA18_RS16470	COG2719	SpoVR family
XA18_RS16475	COG2718	Belongs to the UPF0229 family
XA18_RS16495	COG1804	L-carnitine dehydratase bile acid-inducible protein F
XA18_RS16510	COG1960	acyl-CoA dehydrogenase activity
XA18_RS16560	COG2030	dehydratase
XA18_RS16610	COG0328	RNA-DNA hybrid ribonuclease activity
XA18_RS16615	COG2226	methyltransferase
XA18_RS16620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XA18_RS16625	COG1388	LysM domain
XA18_RS16625	COG0741	lytic transglycosylase activity
XA18_RS16645	COG2979	Protein of unknown function (DUF533)
XA18_RS16685	COG1271	oxidase subunit
XA18_RS16690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XA18_RS16695	COG0850	regulation of cytokinetic process
XA18_RS16700	COG2894	cell division
XA18_RS16705	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
XA18_RS16740	COG0601	transmembrane transport
XA18_RS16750	COG1215	transferase activity, transferring glycosyl groups
XA18_RS16765	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XA18_RS16775	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XA18_RS16795	COG0318	PFAM AMP-dependent synthetase and ligase
XA18_RS16800	COG2188	Transcriptional regulator
XA18_RS16805	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XA18_RS16810	COG2814	Major facilitator Superfamily
XA18_RS16820	COG0259	pyridoxamine-phosphate oxidase activity
XA18_RS16825	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
XA18_RS16840	COG0583	DNA-binding transcription factor activity
XA18_RS16865	COG0134	indole-3-glycerol-phosphate synthase activity
XA18_RS16870	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XA18_RS16875	COG0512	Glutamine amidotransferase of anthranilate synthase
XA18_RS16885	COG0546	phosphoglycolate phosphatase activity
XA18_RS16890	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
XA18_RS16895	COG2967	ApaG domain
XA18_RS16900	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
XA18_RS16905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XA18_RS16910	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XA18_RS16915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XA18_RS16925	COG0037	tRNA processing
XA18_RS16935	COG3634	alkyl hydroperoxide reductase activity
XA18_RS16940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XA18_RS16945	COG1024	Enoyl-CoA hydratase
XA18_RS16970	COG0356	it plays a direct role in the translocation of protons across the membrane
XA18_RS16980	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XA18_RS16985	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XA18_RS16990	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XA18_RS16995	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XA18_RS17000	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XA18_RS17005	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XA18_RS17015	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XA18_RS17020	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XA18_RS17025	COG0210	DNA helicase
XA18_RS17035	COG2195	Cleaves the N-terminal amino acid of tripeptides
XA18_RS17045	COG4172	Belongs to the ABC transporter superfamily
XA18_RS17050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XA18_RS17055	COG0601	transmembrane transport
XA18_RS17075	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XA18_RS17080	COG1024	Enoyl-CoA hydratase
XA18_RS17085	COG1024	Enoyl-CoA hydratase
XA18_RS17140	COG2132	Multicopper oxidase
XA18_RS17150	COG1024	Enoyl-CoA hydratase
XA18_RS17150	COG1250	3-hydroxyacyl-CoA dehydrogenase
XA18_RS17160	COG1414	Transcriptional regulator
XA18_RS17170	COG0154	amidase activity
XA18_RS17200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XA18_RS17205	COG3568	Endonuclease Exonuclease Phosphatase
XA18_RS17210	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XA18_RS17245	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
XA18_RS17255	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XA18_RS17270	COG1137	ATPase activity
XA18_RS17285	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
XA18_RS17290	COG2010	Cytochrome c
XA18_RS17290	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XA18_RS17300	COG1660	Displays ATPase and GTPase activities
XA18_RS17305	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XA18_RS17340	COG3181	Tripartite tricarboxylate transporter family receptor
XA18_RS17350	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XA18_RS17355	COG2890	protein-(glutamine-N5) methyltransferase activity
XA18_RS17360	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XA18_RS17365	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XA18_RS17415	COG1960	acyl-CoA dehydrogenase activity
XA18_RS17425	COG0183	Belongs to the thiolase family
XA18_RS17430	COG1522	sequence-specific DNA binding
XA18_RS17435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XA18_RS17455	COG1024	Enoyl-CoA hydratase
XA18_RS17470	COG0604	alcohol dehydrogenase
XA18_RS17490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XA18_RS17500	COG1960	acyl-CoA dehydrogenase activity
XA18_RS17505	COG1960	acyl-CoA dehydrogenase activity
XA18_RS17510	COG0277	FAD linked oxidase domain protein
XA18_RS17520	COG3181	Tripartite tricarboxylate transporter family receptor
XA18_RS17545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XA18_RS17555	COG1804	L-carnitine dehydratase bile acid-inducible protein F
XA18_RS17560	COG3181	Tripartite tricarboxylate transporter family receptor
XA18_RS17565	COG1960	acyl-CoA dehydrogenase activity
XA18_RS17585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XA18_RS17590	COG1024	Enoyl-CoA hydratase
XA18_RS17595	COG1960	acyl-CoA dehydrogenase activity
XA18_RS17615	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
XA18_RS17620	COG0022	dehydrogenase e1 component
XA18_RS17625	COG1024	Enoyl-CoA hydratase
XA18_RS17630	COG0508	dehydrogenase complex catalyzes the overall conversion of
XA18_RS17650	COG0683	leucine binding
XA18_RS17655	COG0559	Belongs to the binding-protein-dependent transport system permease family
XA18_RS17660	COG0411	ABC transporter
XA18_RS17670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XA18_RS17685	COG3181	Tripartite tricarboxylate transporter family receptor
XA18_RS17715	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XA18_RS17720	COG0793	Belongs to the peptidase S41A family
XA18_RS17725	COG4942	peptidase
XA18_RS17730	COG0588	phosphoglycerate mutase activity
XA18_RS17735	COG1054	Belongs to the UPF0176 family
XA18_RS17740	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
XA18_RS17745	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XA18_RS17750	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XA18_RS17755	COG3181	Tripartite tricarboxylate transporter family receptor
XA18_RS17770	COG2226	methyltransferase
XA18_RS17775	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
XA18_RS17790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XA18_RS17795	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
XA18_RS17820	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
XA18_RS17845	COG1335	isochorismatase
XA18_RS17850	COG2309	aminopeptidase activity
XA18_RS17860	COG3473	Maleate cis-trans isomerase
XA18_RS17870	COG2068	MobA-Related Protein
XA18_RS17895	COG2204	response regulator
XA18_RS17900	COG5000	phosphorelay sensor kinase activity
XA18_RS17910	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
XA18_RS17910	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XA18_RS17920	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
XA18_RS17955	COG0583	DNA-binding transcription factor activity
XA18_RS17975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XA18_RS17980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XA18_RS17995	COG0758	DNA mediated transformation
XA18_RS18000	COG1522	sequence-specific DNA binding
XA18_RS18010	COG0242	peptide deformylase activity
XA18_RS18025	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XA18_RS18035	COG0546	phosphoglycolate phosphatase activity
XA18_RS18055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XA18_RS18060	COG1942	4-Oxalocrotonate Tautomerase
XA18_RS18065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XA18_RS18090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XA18_RS18110	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XA18_RS18115	COG1024	Enoyl-CoA hydratase
XA18_RS18120	COG1414	Transcriptional regulator
XA18_RS18125	COG0318	PFAM AMP-dependent synthetase and ligase
XA18_RS18130	COG3181	Tripartite tricarboxylate transporter family receptor
XA18_RS18175	COG3422	double-strand break repair
XA18_RS18180	COG0330	HflC and HflK could
XA18_RS18190	COG0251	oxidation-reduction process
XA18_RS18240	COG3723	Recombinational DNA repair protein, rece pathway
XA18_RS18275	COG0582	viral genome integration into host DNA
XA18_RS18310	COG0706	membrane insertase activity
XA18_RS18315	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XA18_RS18320	COG0594	ribonuclease P activity
XA18_RS18325	COG0230	Belongs to the bacterial ribosomal protein bL34 family
XA18_RS18330	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XA18_RS18345	COG1414	Transcriptional regulator
XA18_RS18350	COG0154	amidase activity
XA18_RS18365	COG1304	FMN binding
XA18_RS18415	COG0183	Belongs to the thiolase family
XA18_RS18420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
XA18_RS18435	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XA18_RS18440	COG3181	Tripartite tricarboxylate transporter family receptor
XA18_RS18450	COG2358	TRAP transporter, solute receptor (TAXI family
XA18_RS18460	COG1629	transport
XA18_RS18465	COG2922	Belongs to the Smg family
XA18_RS18490	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
XA18_RS18495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XA18_RS18500	COG1028	Short-chain dehydrogenase reductase Sdr
XA18_RS18505	COG1012	belongs to the aldehyde dehydrogenase family
XA18_RS18515	COG0028	Belongs to the TPP enzyme family
XA18_RS18520	COG1522	sequence-specific DNA binding
XA18_RS18525	COG3781	membrane
XA18_RS18535	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
XA18_RS18555	COG4206	TonB-dependent receptor
XA18_RS18560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
XA18_RS18565	COG2022	thiamine diphosphate biosynthetic process
XA18_RS18570	COG0351	phosphomethylpyrimidine kinase
XA18_RS18575	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XA18_RS18590	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
XA18_RS18600	COG0628	permease
XA18_RS18610	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XA18_RS18625	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
XA18_RS18630	COG0049	tRNA binding
XA18_RS18635	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XA18_RS18640	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XA18_RS18645	COG0051	transcription antitermination factor activity, RNA binding
XA18_RS18650	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XA18_RS18655	COG0088	Forms part of the polypeptide exit tunnel
XA18_RS18660	COG0089	rRNA binding
XA18_RS18665	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XA18_RS18670	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XA18_RS18675	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
XA18_RS18680	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
XA18_RS18685	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
XA18_RS18690	COG0255	Belongs to the universal ribosomal protein uL29 family
XA18_RS18695	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XA18_RS18715	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
XA18_RS18720	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XA18_RS18725	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XA18_RS18730	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
XA18_RS18735	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XA18_RS18740	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XA18_RS18745	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
XA18_RS18750	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
XA18_RS18755	COG1841	ribosomal large subunit assembly
XA18_RS18760	COG0200	Binds to the 23S rRNA
XA18_RS18765	COG0201	protein transport
XA18_RS18770	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
XA18_RS18775	COG0257	Belongs to the bacterial ribosomal protein bL36 family
XA18_RS18780	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
XA18_RS18785	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
XA18_RS18790	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
XA18_RS18795	COG0202	RNA polymerase activity
XA18_RS18800	COG0203	ribosomal protein L17
XA18_RS18805	COG0537	adenosine 5'-monophosphoramidase activity
XA18_RS18810	COG1324	tolerance protein
XA18_RS18815	COG4232	protein-disulfide reductase activity
XA18_RS18830	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XA18_RS18840	COG1333	cytochrome c biogenesis protein
XA18_RS18845	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XA18_RS18860	COG1965	Belongs to the frataxin family
XA18_RS18870	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XA18_RS18875	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XA18_RS18880	COG0232	Belongs to the dGTPase family. Type 2 subfamily
XA18_RS18895	COG2814	Major facilitator Superfamily
XA18_RS18900	COG0629	single-stranded DNA binding
XA18_RS18940	COG0402	S-adenosylhomocysteine deaminase activity
XA18_RS18950	COG0438	transferase activity, transferring glycosyl groups
XA18_RS18970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XA18_RS18995	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
XA18_RS19020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XA18_RS19025	COG1956	GAF domain-containing protein
XA18_RS19030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XA18_RS19045	COG1652	LysM domain
XA18_RS19060	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XA18_RS19075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XA18_RS19105	COG3181	Tripartite tricarboxylate transporter family receptor
XA18_RS19120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XA18_RS19135	COG1024	Enoyl-CoA hydratase
XA18_RS19150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
XA18_RS19155	COG1309	transcriptional regulator
XA18_RS19160	COG2816	NAD+ diphosphatase activity
XA18_RS19165	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
XA18_RS19250	COG2814	Major facilitator Superfamily
XA18_RS19255	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XA18_RS19275	COG1999	signal sequence binding
XA18_RS19280	COG0109	protoheme IX farnesyltransferase activity
XA18_RS19320	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XA18_RS19340	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
XA18_RS19345	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XA18_RS19355	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
XA18_RS19360	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
XA18_RS19370	COG0069	glutamate synthase activity
XA18_RS19370	COG0070	glutamate synthase
XA18_RS19370	COG0067	glutamate synthase
XA18_RS19380	COG3047	cAMP biosynthetic process
XA18_RS19390	COG1127	ABC transporter
XA18_RS19395	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XA18_RS19400	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XA18_RS19405	COG2853	Lipoprotein
XA18_RS19420	COG0842	Transport permease protein
XA18_RS19430	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XA18_RS19435	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XA18_RS19440	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XA18_RS19445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XA18_RS19450	COG0131	Imidazoleglycerol-phosphate dehydratase
XA18_RS19455	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
XA18_RS19460	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XA18_RS19465	COG0107	imidazoleglycerol-phosphate synthase activity
XA18_RS19470	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XA18_RS19475	COG0140	phosphoribosyl-ATP diphosphatase activity
XA18_RS19480	COG0537	adenosine 5'-monophosphoramidase activity
XA18_RS19485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XA18_RS19490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XA18_RS19505	COG3181	Tripartite tricarboxylate transporter family receptor
XA18_RS19540	COG3702	type iv secretory pathway
XA18_RS19545	COG3451	type IV secretory pathway VirB4
XA18_RS19560	COG3736	Type IV secretory pathway, component VirB8
XA18_RS19565	COG3504	Conjugal transfer protein
XA18_RS19570	COG2948	multi-organism process
XA18_RS19575	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
XA18_RS19585	COG0697	spore germination
XA18_RS19605	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XA18_RS19610	COG0747	negative chemotaxis
XA18_RS19615	COG0601	transmembrane transport
XA18_RS19620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XA18_RS19635	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
XA18_RS19645	COG0494	nUDIX hydrolase
XA18_RS19690	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
XA18_RS19695	COG0237	dephospho-CoA kinase activity
XA18_RS19700	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XA18_RS19715	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XA18_RS19720	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XA18_RS19730	COG0477	Major facilitator Superfamily
XA18_RS19735	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XA18_RS19750	COG1126	abc transporter atp-binding protein
XA18_RS19755	COG0765	amino acid transport
XA18_RS19760	COG4597	amino acid ABC transporter
XA18_RS19765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XA18_RS19770	COG2884	Cell division ATP-binding protein ftsE
XA18_RS19775	COG2177	Part of the ABC transporter FtsEX involved in
XA18_RS19780	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
XA18_RS19790	COG1194	a g-specific adenine glycosylase
XA18_RS19800	COG2226	methyltransferase
XA18_RS19810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
XA18_RS19815	COG1804	L-carnitine dehydratase bile acid-inducible protein F
XA18_RS19830	COG1024	Enoyl-CoA hydratase
XA18_RS19850	COG1024	Enoyl-CoA hydratase
XA18_RS19855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
XA18_RS19870	COG0753	catalase activity
XA18_RS19875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XA18_RS19880	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
XA18_RS19890	COG2175	clavaminate synthase activity
XA18_RS19895	COG1473	amidohydrolase
XA18_RS19900	COG4608	Belongs to the ABC transporter superfamily
XA18_RS19905	COG0444	Belongs to the ABC transporter superfamily
XA18_RS19920	COG0747	negative chemotaxis
XA18_RS19925	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XA18_RS19960	COG0436	Aminotransferase
XA18_RS19965	COG1278	Cold shock