locus-tag	class	description
C4C67_RS00005	COG0445	tRNA wobble uridine modification
C4C67_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
C4C67_RS00015	COG1192	Involved in chromosome partitioning
C4C67_RS00025	COG1475	DNA binding
C4C67_RS00050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4C67_RS00060	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C4C67_RS00070	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C4C67_RS00075	COG0081	regulation of translation
C4C67_RS00080	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C4C67_RS00085	COG0222	ribosome binding
C4C67_RS00090	COG0085	RNA polymerase activity
C4C67_RS00095	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C4C67_RS00145	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4C67_RS00170	COG1024	Enoyl-CoA hydratase
C4C67_RS00190	COG0752	glycyl-tRNA synthetase alpha subunit
C4C67_RS00195	COG0751	glycine-tRNA ligase activity
C4C67_RS00200	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C4C67_RS00205	COG0204	Acyl-transferase
C4C67_RS00220	COG0242	peptide deformylase activity
C4C67_RS00260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4C67_RS00265	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4C67_RS00265	COG2813	Specifically methylates the guanine in position
C4C67_RS00280	COG2223	nitrite transmembrane transporter activity
C4C67_RS00290	COG1794	racemase activity, acting on amino acids and derivatives
C4C67_RS00295	COG1126	abc transporter atp-binding protein
C4C67_RS00300	COG0765	amino acid transport
C4C67_RS00305	COG0765	amino acid transport
C4C67_RS00310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4C67_RS00375	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C4C67_RS00405	COG0326	Molecular chaperone. Has ATPase activity
C4C67_RS00410	COG0625	glutathione transferase activity
C4C67_RS00425	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C4C67_RS00430	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C4C67_RS00460	COG0438	transferase activity, transferring glycosyl groups
C4C67_RS00465	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4C67_RS00470	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4C67_RS00500	COG0859	PFAM glycosyl transferase family 9
C4C67_RS00515	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C4C67_RS00525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4C67_RS00530	COG1127	ABC transporter
C4C67_RS00550	COG1686	Belongs to the peptidase S11 family
C4C67_RS00560	COG2921	Belongs to the UPF0250 family
C4C67_RS00565	COG0321	lipoyl(octanoyl) transferase activity
C4C67_RS00570	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C4C67_RS00605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C4C67_RS00615	COG0018	arginyl-trna synthetase
C4C67_RS00635	COG0395	ABC-type sugar transport system, permease component
C4C67_RS00640	COG1175	transmembrane transport
C4C67_RS00645	COG1653	transport
C4C67_RS00650	COG3842	ATPase activity
C4C67_RS00655	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4C67_RS00665	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C4C67_RS00685	COG1609	Transcriptional regulator
C4C67_RS00695	COG0154	amidase activity
C4C67_RS00700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4C67_RS00710	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C4C67_RS00720	COG0583	DNA-binding transcription factor activity
C4C67_RS00740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4C67_RS00755	COG1802	Transcriptional regulator
C4C67_RS00770	COG1024	Enoyl-CoA hydratase
C4C67_RS00780	COG3181	Tripartite tricarboxylate transporter family receptor
C4C67_RS00795	COG1984	allophanate hydrolase subunit 2
C4C67_RS00800	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C4C67_RS00810	COG0583	DNA-binding transcription factor activity
C4C67_RS00815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4C67_RS00825	COG5002	protein histidine kinase activity
C4C67_RS00835	COG5002	protein histidine kinase activity
C4C67_RS00840	COG0745	RESPONSE REGULATOR receiver
C4C67_RS00845	COG2226	methyltransferase
C4C67_RS00860	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C4C67_RS00880	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C4C67_RS00890	COG0513	Belongs to the DEAD box helicase family
C4C67_RS00895	COG1280	lysine exporter protein (LysE YggA)
C4C67_RS00900	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C4C67_RS00940	COG1054	Belongs to the UPF0176 family
C4C67_RS00945	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4C67_RS00945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4C67_RS00955	COG0489	protein tyrosine kinase activity
C4C67_RS00970	COG0717	Belongs to the dCTP deaminase family
C4C67_RS01000	COG2081	HI0933 family
C4C67_RS01010	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C4C67_RS01020	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4C67_RS01025	COG0509	glycine decarboxylation via glycine cleavage system
C4C67_RS01030	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4C67_RS01030	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4C67_RS01070	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4C67_RS01085	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C4C67_RS01095	COG1414	Transcriptional regulator
C4C67_RS01100	COG1028	Short-chain dehydrogenase reductase Sdr
C4C67_RS01105	COG2031	fatty acid transporter
C4C67_RS01110	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4C67_RS01120	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C4C67_RS01125	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C4C67_RS01135	COG4257	antibiotic catabolic process
C4C67_RS01160	COG1012	belongs to the aldehyde dehydrogenase family
C4C67_RS01165	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C4C67_RS01170	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C4C67_RS01195	COG1028	Short-chain dehydrogenase reductase Sdr
C4C67_RS01205	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4C67_RS01215	COG2188	Transcriptional regulator
C4C67_RS01220	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C4C67_RS01245	COG0617	tRNA 3'-terminal CCA addition
C4C67_RS01260	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C4C67_RS01265	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C4C67_RS01270	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C4C67_RS01275	COG0586	Pfam SNARE associated Golgi protein
C4C67_RS01280	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4C67_RS01285	COG0802	atpase or kinase
C4C67_RS01290	COG0114	fumarate hydratase activity
C4C67_RS01300	COG3181	Tripartite tricarboxylate transporter family receptor
C4C67_RS01310	COG0405	Gamma-glutamyltransferase
C4C67_RS01315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4C67_RS01350	COG1294	oxidase, subunit
C4C67_RS01360	COG4988	ABC transporter
C4C67_RS01365	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C4C67_RS01415	COG2969	positive regulation of protein catabolic process
C4C67_RS01420	COG0625	glutathione transferase activity
C4C67_RS01425	COG2857	Cytochrome c1
C4C67_RS01430	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C4C67_RS01435	COG0723	plastoquinol--plastocyanin reductase activity
C4C67_RS01440	COG1970	mechanosensitive ion channel activity
C4C67_RS01445	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C4C67_RS01460	COG2808	Putative FMN-binding domain
C4C67_RS01465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4C67_RS01470	COG0747	negative chemotaxis
C4C67_RS01475	COG0657	acetylesterase activity
C4C67_RS01485	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4C67_RS01490	COG2207	Transcriptional regulator
C4C67_RS01495	COG0129	dihydroxy-acid dehydratase activity
C4C67_RS01500	COG2814	Major facilitator Superfamily
C4C67_RS01505	COG0583	DNA-binding transcription factor activity
C4C67_RS01515	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
C4C67_RS01585	COG1024	Enoyl-CoA hydratase
C4C67_RS01590	COG1960	acyl-CoA dehydrogenase activity
C4C67_RS01615	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C4C67_RS01620	COG0352	thiamine-phosphate diphosphorylase activity
C4C67_RS01635	COG1678	Uncharacterized ACR, COG1678
C4C67_RS01640	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C4C67_RS01645	COG0540	Belongs to the ATCase OTCase family
C4C67_RS01660	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4C67_RS01670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4C67_RS01705	COG1234	tRNA 3'-trailer cleavage
C4C67_RS01725	COG3064	Membrane
C4C67_RS01755	COG1683	Conserved Protein
C4C67_RS01760	COG1120	ATPase activity
C4C67_RS01765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4C67_RS01770	COG4558	Periplasmic binding protein
C4C67_RS01775	COG3720	iron ion transport
C4C67_RS01785	COG3712	iron ion homeostasis
C4C67_RS01790	COG1595	DNA-templated transcription, initiation
C4C67_RS01825	COG1802	Transcriptional regulator
C4C67_RS01835	COG3069	C4-dicarboxylate transmembrane transporter activity
C4C67_RS01845	COG1012	belongs to the aldehyde dehydrogenase family
C4C67_RS01880	COG2860	membrane
C4C67_RS01885	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C4C67_RS01890	COG0708	Exodeoxyribonuclease III
C4C67_RS01895	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C4C67_RS01900	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4C67_RS01905	COG0154	amidase activity
C4C67_RS01910	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4C67_RS01915	COG1077	Cell shape determining protein MreB Mrl
C4C67_RS01920	COG1792	Involved in formation and maintenance of cell shape
C4C67_RS01930	COG0768	penicillin binding
C4C67_RS01935	COG0772	Belongs to the SEDS family
C4C67_RS01940	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C4C67_RS01945	COG0471	metal ion transport
C4C67_RS01950	COG1309	transcriptional regulator
C4C67_RS01960	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4C67_RS01975	COG2823	Periplasmic or secreted lipoprotein
C4C67_RS01980	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C4C67_RS01995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4C67_RS02015	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4C67_RS02025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4C67_RS02045	COG0492	ferredoxin-NADP+ reductase activity
C4C67_RS02055	COG3181	Tripartite tricarboxylate transporter family receptor
C4C67_RS02060	COG1024	Enoyl-CoA hydratase
C4C67_RS02060	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4C67_RS02065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4C67_RS02070	COG0028	Belongs to the TPP enzyme family
C4C67_RS02095	COG3181	Tripartite tricarboxylate transporter family receptor
C4C67_RS02110	COG0697	spore germination
C4C67_RS02140	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4C67_RS02145	COG0463	Glycosyl transferase, family 2
C4C67_RS02160	COG0786	glutamate:sodium symporter activity
C4C67_RS02170	COG2031	fatty acid transporter
C4C67_RS02185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4C67_RS02200	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4C67_RS02215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4C67_RS02225	COG1285	pathogenesis
C4C67_RS02230	COG1253	flavin adenine dinucleotide binding
C4C67_RS02235	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4C67_RS02240	COG1024	Enoyl-CoA hydratase
C4C67_RS02245	COG3181	Tripartite tricarboxylate transporter family receptor
C4C67_RS02250	COG0583	DNA-binding transcription factor activity
C4C67_RS02255	COG1960	acyl-CoA dehydrogenase activity
C4C67_RS02265	COG0183	Belongs to the thiolase family
C4C67_RS02280	COG0583	DNA-binding transcription factor activity
C4C67_RS02285	COG1278	Cold shock
C4C67_RS02295	COG1802	Transcriptional regulator
C4C67_RS02300	COG1012	belongs to the aldehyde dehydrogenase family
C4C67_RS02305	COG2031	fatty acid transporter
C4C67_RS02310	COG1017	nitric oxide dioxygenase activity
C4C67_RS02310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4C67_RS02315	COG0251	oxidation-reduction process
C4C67_RS02335	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4C67_RS02345	COG0583	DNA-binding transcription factor activity
C4C67_RS02350	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4C67_RS02365	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C4C67_RS02370	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C4C67_RS02375	COG0546	phosphoglycolate phosphatase activity
C4C67_RS02385	COG1530	ribonuclease E activity
C4C67_RS02405	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C4C67_RS02410	COG0159	tryptophan synthase activity
C4C67_RS02415	COG0133	tryptophan synthase activity
C4C67_RS02425	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4C67_RS02430	COG3228	Belongs to the MtfA family
C4C67_RS02440	COG0251	oxidation-reduction process
C4C67_RS02445	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C4C67_RS02450	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C4C67_RS02465	COG2878	Part of a membrane complex involved in electron transport
C4C67_RS02470	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C4C67_RS02505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4C67_RS02525	COG1268	BioY protein
C4C67_RS02530	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C4C67_RS02535	COG1122	ATPase activity
C4C67_RS02540	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4C67_RS02555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4C67_RS02560	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4C67_RS02570	COG1196	nuclear chromosome segregation
C4C67_RS02575	COG0477	Major facilitator Superfamily
C4C67_RS02580	COG1573	uracil-dna glycosylase
C4C67_RS02585	COG1214	PFAM Peptidase M22, glycoprotease
C4C67_RS02605	COG0450	alkyl hydroperoxide reductase
C4C67_RS02610	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4C67_RS02620	COG2223	nitrite transmembrane transporter activity
C4C67_RS02630	COG2186	Transcriptional regulator
C4C67_RS02650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4C67_RS02660	COG0583	DNA-binding transcription factor activity
C4C67_RS02670	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4C67_RS02675	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4C67_RS02680	COG0137	argininosuccinate synthase activity
C4C67_RS02685	COG3158	transport of potassium into the cell
C4C67_RS02690	COG0642	Histidine kinase
C4C67_RS02720	COG0776	regulation of translation
C4C67_RS02725	COG3128	pkhd-type hydroxylase
C4C67_RS02735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4C67_RS02740	COG0557	exoribonuclease II activity
C4C67_RS02765	COG0679	Auxin Efflux Carrier
C4C67_RS02770	COG2391	methyltransferase activity
C4C67_RS02775	COG0069	glutamate synthase activity
C4C67_RS02785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4C67_RS02795	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
C4C67_RS02835	COG3706	GGDEF domain
C4C67_RS02860	COG1053	succinate dehydrogenase
C4C67_RS02865	COG0583	DNA-binding transcription factor activity
C4C67_RS02880	COG1053	succinate dehydrogenase
C4C67_RS02900	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C4C67_RS02905	COG0459	protein refolding
C4C67_RS02910	COG3468	outer membrane autotransporter barrel domain protein
C4C67_RS02925	COG1252	NADH dehydrogenase
C4C67_RS02930	COG0284	orotidine-5'-phosphate decarboxylase activity
C4C67_RS02935	COG1546	Belongs to the CinA family
C4C67_RS02935	COG1058	Belongs to the CinA family
C4C67_RS02940	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C4C67_RS02950	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4C67_RS02955	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4C67_RS02995	COG3639	organic phosphonate transmembrane transporter activity
C4C67_RS03000	COG3639	organic phosphonate transmembrane transporter activity
C4C67_RS03020	COG0742	ribosomal rna small subunit methyltransferase
C4C67_RS03025	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C4C67_RS03030	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4C67_RS03035	COG3135	benzoate transporter
C4C67_RS03050	COG0640	Transcriptional regulator
C4C67_RS03080	COG4172	Belongs to the ABC transporter superfamily
C4C67_RS03085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4C67_RS03090	COG0601	transmembrane transport
C4C67_RS03100	COG0281	malic enzyme
C4C67_RS03100	COG0280	phosphate acetyltransferase
C4C67_RS03160	COG0583	DNA-binding transcription factor activity
C4C67_RS03175	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C4C67_RS03180	COG0167	dihydroorotate dehydrogenase activity
C4C67_RS03200	COG1414	Transcriptional regulator
C4C67_RS03205	COG1058	Belongs to the CinA family
C4C67_RS03205	COG1546	Belongs to the CinA family
C4C67_RS03225	COG0513	Belongs to the DEAD box helicase family
C4C67_RS03255	COG0429	hydrolase of the alpha beta-hydrolase fold
C4C67_RS03260	COG4783	chaperone-mediated protein folding
C4C67_RS03275	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C4C67_RS03300	COG0006	proline dipeptidase activity
C4C67_RS03310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4C67_RS03330	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C4C67_RS03335	COG0632	four-way junction helicase activity
C4C67_RS03350	COG2255	four-way junction helicase activity
C4C67_RS03355	COG0514	ATP-dependent DNA helicase (RecQ)
C4C67_RS03370	COG0288	reversible hydration of carbon dioxide
C4C67_RS03375	COG0154	amidase activity
C4C67_RS03385	COG4211	Belongs to the binding-protein-dependent transport system permease family
C4C67_RS03415	COG1464	Belongs to the NlpA lipoprotein family
C4C67_RS03555	COG1196	nuclear chromosome segregation
C4C67_RS03630	COG2135	peptidase activity
C4C67_RS03645	COG0494	nUDIX hydrolase
C4C67_RS03650	COG0442	prolyl-tRNA aminoacylation
C4C67_RS03655	COG0824	Thioesterase
C4C67_RS03660	COG0811	peptide transport
C4C67_RS03665	COG0848	biopolymer transport protein
C4C67_RS03675	COG0823	Involved in the tonB-independent uptake of proteins
C4C67_RS03690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4C67_RS03695	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C4C67_RS03730	COG0700	Nucleoside recognition
C4C67_RS03735	COG0469	pyruvate kinase activity
C4C67_RS03740	COG1929	Belongs to the glycerate kinase type-1 family
C4C67_RS03745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C4C67_RS03750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4C67_RS03755	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C4C67_RS03765	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4C67_RS03775	COG2154	pterin-4-alpha-carbinolamine dehydratase
C4C67_RS03800	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C4C67_RS03805	COG0154	amidase activity
C4C67_RS03815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4C67_RS03820	COG0601	transmembrane transport
C4C67_RS03825	COG0747	negative chemotaxis
C4C67_RS03845	COG0019	diaminopimelate decarboxylase activity
C4C67_RS03860	COG2353	YceI-like domain
C4C67_RS03865	COG4774	siderophore transport
C4C67_RS03870	COG3712	iron ion homeostasis
C4C67_RS03915	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C4C67_RS03920	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4C67_RS03925	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C4C67_RS03930	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C4C67_RS03940	COG0142	geranyltranstransferase activity
C4C67_RS03950	COG0583	DNA-binding transcription factor activity
C4C67_RS03960	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
C4C67_RS03965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4C67_RS03985	COG2994	toxin metabolic process
C4C67_RS03995	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C4C67_RS04000	COG2274	protein secretion by the type I secretion system
C4C67_RS04005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4C67_RS04010	COG1538	Outer membrane efflux protein
C4C67_RS04030	COG0765	amino acid transport
C4C67_RS04035	COG1126	abc transporter atp-binding protein
C4C67_RS04055	COG1028	Short-chain dehydrogenase reductase Sdr
C4C67_RS04065	COG1802	Transcriptional regulator
C4C67_RS04075	COG1802	Transcriptional regulator
C4C67_RS04085	COG0318	PFAM AMP-dependent synthetase and ligase
C4C67_RS04095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4C67_RS04115	COG0028	Belongs to the TPP enzyme family
C4C67_RS04135	COG0308	aminopeptidase N
C4C67_RS04140	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C4C67_RS04155	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C4C67_RS04160	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C4C67_RS04165	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C4C67_RS04170	COG0560	Phosphoserine phosphatase
C4C67_RS04175	COG0583	DNA-binding transcription factor activity
C4C67_RS04180	COG3181	Tripartite tricarboxylate transporter family receptor
C4C67_RS04185	COG0028	Belongs to the TPP enzyme family
C4C67_RS04200	COG4774	siderophore transport
C4C67_RS04205	COG4774	siderophore transport
C4C67_RS04215	COG1007	ATP synthesis coupled electron transport
C4C67_RS04230	COG0713	ATP synthesis coupled electron transport
C4C67_RS04240	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4C67_RS04245	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C4C67_RS04250	COG1034	ATP synthesis coupled electron transport
C4C67_RS04260	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C4C67_RS04265	COG0649	NAD binding
C4C67_RS04270	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4C67_RS04275	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4C67_RS04280	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4C67_RS04285	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C4C67_RS04315	COG0671	phosphoesterase, PA-phosphatase related
C4C67_RS04325	COG1597	lipid kinase activity
C4C67_RS04330	COG0583	DNA-binding transcription factor activity
C4C67_RS04335	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4C67_RS04345	COG1733	regulation of RNA biosynthetic process
C4C67_RS04350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4C67_RS04355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4C67_RS04370	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
C4C67_RS04390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4C67_RS04410	COG3608	succinylglutamate desuccinylase aspartoacylase
C4C67_RS04415	COG0626	cystathionine gamma-synthase activity
C4C67_RS04420	COG0583	DNA-binding transcription factor activity
C4C67_RS04455	COG3799	methylaspartate ammonia-lyase activity
C4C67_RS04465	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4C67_RS04475	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C4C67_RS04480	COG0149	triose-phosphate isomerase activity
C4C67_RS04500	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4C67_RS04515	COG1185	polyribonucleotide nucleotidyltransferase activity
C4C67_RS04520	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C4C67_RS04535	COG1183	phosphatidylcholine synthase activity
C4C67_RS04540	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C4C67_RS04545	COG0440	acetolactate synthase activity
C4C67_RS04550	COG0028	Belongs to the TPP enzyme family
C4C67_RS04565	COG5265	(ABC) transporter
C4C67_RS04570	COG0500	methyltransferase
C4C67_RS04590	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C4C67_RS04610	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C4C67_RS04620	COG0511	ligase activity, forming carbon-carbon bonds
C4C67_RS04645	COG2188	Transcriptional regulator
C4C67_RS04650	COG0439	Biotin carboxylase
C4C67_RS04700	COG5265	(ABC) transporter
C4C67_RS04710	COG0667	Aldo Keto reductase
C4C67_RS04725	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4C67_RS04765	COG0583	DNA-binding transcription factor activity
C4C67_RS04800	COG2814	Major facilitator Superfamily
C4C67_RS04810	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4C67_RS04825	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C4C67_RS04835	COG0287	Prephenate dehydrogenase
C4C67_RS04840	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4C67_RS04845	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C4C67_RS04865	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C4C67_RS04870	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C4C67_RS04875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4C67_RS04880	COG1596	polysaccharide export
C4C67_RS04880	COG1555	photosystem II stabilization
C4C67_RS04895	COG2951	lytic endotransglycosylase activity
C4C67_RS04900	COG0123	including yeast histone deacetylase and acetoin utilization protein
C4C67_RS04915	COG1960	acyl-CoA dehydrogenase activity
C4C67_RS04920	COG0450	alkyl hydroperoxide reductase
C4C67_RS04940	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C4C67_RS04975	COG0335	large ribosomal subunit rRNA binding
C4C67_RS04990	COG0667	Aldo Keto reductase
C4C67_RS05005	COG3161	chorismate lyase activity
C4C67_RS05010	COG1187	pseudouridine synthase activity
C4C67_RS05040	COG1999	signal sequence binding
C4C67_RS05045	COG0339	signal peptide processing
C4C67_RS05050	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4C67_RS05055	COG4566	intracellular signal transduction
C4C67_RS05065	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C4C67_RS05070	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4C67_RS05075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4C67_RS05080	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C4C67_RS05105	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C4C67_RS05110	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C4C67_RS05115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C4C67_RS05120	COG0126	phosphoglycerate kinase activity
C4C67_RS05125	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C4C67_RS05130	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C4C67_RS05145	COG0625	glutathione transferase activity
C4C67_RS05175	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C4C67_RS05185	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4C67_RS05195	COG0739	heme binding
C4C67_RS05205	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C4C67_RS05240	COG0745	RESPONSE REGULATOR receiver
C4C67_RS05255	COG0840	transmembrane signaling receptor activity
C4C67_RS05265	COG2201	protein-glutamate methylesterase activity
C4C67_RS05270	COG0745	RESPONSE REGULATOR receiver
C4C67_RS05275	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C4C67_RS05300	COG0667	Aldo Keto reductase
C4C67_RS05310	COG4535	Mg2 and Co2 transporter CorC
C4C67_RS05315	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C4C67_RS05320	COG1702	phosphate starvation-inducible protein PhoH
C4C67_RS05325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4C67_RS05340	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C4C67_RS05345	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C4C67_RS05350	COG1862	Preprotein translocase
C4C67_RS05355	COG0343	queuine tRNA-ribosyltransferase activity
C4C67_RS05360	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C4C67_RS05365	COG2027	D-alanyl-D-alanine carboxypeptidase
C4C67_RS05370	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C4C67_RS05395	COG1648	precorrin-2 dehydrogenase activity
C4C67_RS05395	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4C67_RS05420	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C4C67_RS05425	COG0741	lytic transglycosylase activity
C4C67_RS05435	COG0436	Aminotransferase
C4C67_RS05445	COG0280	phosphate acetyltransferase
C4C67_RS05445	COG0281	malic enzyme
C4C67_RS05455	COG2732	(Barnase) inhibitor
C4C67_RS05470	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4C67_RS05495	COG0248	Ppx GppA phosphatase
C4C67_RS05505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4C67_RS05515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C4C67_RS05520	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C4C67_RS05525	COG1534	Rna-binding protein
C4C67_RS05555	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4C67_RS05570	COG1295	ribonuclease BN
C4C67_RS05580	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C4C67_RS05585	COG0745	RESPONSE REGULATOR receiver
C4C67_RS05590	COG2205	protein histidine kinase activity
C4C67_RS05625	COG1022	Amp-dependent synthetase and ligase
C4C67_RS05640	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C4C67_RS05645	COG1028	Short-chain dehydrogenase reductase Sdr
C4C67_RS05655	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C4C67_RS05670	COG1136	(ABC) transporter
C4C67_RS05675	COG0084	hydrolase, TatD family'
C4C67_RS05700	COG0658	competence protein
C4C67_RS05700	COG2333	competence protein COMEC
C4C67_RS05710	COG0613	PHP domain protein
C4C67_RS05730	COG3539	Fimbrial protein
C4C67_RS05735	COG0280	phosphate acetyltransferase
C4C67_RS05735	COG0281	malic enzyme
C4C67_RS05745	COG1522	sequence-specific DNA binding
C4C67_RS05755	COG0567	Dehydrogenase, E1 component
C4C67_RS05760	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4C67_RS05765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4C67_RS05770	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4C67_RS05775	COG1028	Short-chain dehydrogenase reductase Sdr
C4C67_RS05780	COG0583	DNA-binding transcription factor activity
C4C67_RS05790	COG3181	Tripartite tricarboxylate transporter family receptor
C4C67_RS05815	COG0180	Tryptophanyl-tRNA synthetase
C4C67_RS05820	COG2183	response to ionizing radiation
C4C67_RS05825	COG1199	ATP-dependent helicase activity
C4C67_RS05835	COG0564	pseudouridine synthase activity
C4C67_RS05845	COG3243	poly(R)-hydroxyalkanoic acid synthase
C4C67_RS05850	COG1028	Short-chain dehydrogenase reductase Sdr
C4C67_RS05855	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
C4C67_RS05870	COG0672	)-iron permease
C4C67_RS05910	COG0583	DNA-binding transcription factor activity
C4C67_RS05920	COG2814	Major facilitator Superfamily
C4C67_RS05935	COG1619	proteins homologs of microcin C7 resistance protein MccF
C4C67_RS05950	COG2084	Dehydrogenase
C4C67_RS05955	COG3181	Tripartite tricarboxylate transporter family receptor
C4C67_RS05980	COG2988	succinylglutamate desuccinylase activity
C4C67_RS06010	COG0765	amino acid transport
C4C67_RS06015	COG0765	amino acid transport
C4C67_RS06020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4C67_RS06055	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4C67_RS06060	COG1595	DNA-templated transcription, initiation
C4C67_RS06070	COG3530	Putative quorum-sensing-regulated virulence factor
C4C67_RS06075	COG0494	nUDIX hydrolase
C4C67_RS06090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4C67_RS06095	COG0542	response to heat
C4C67_RS06115	COG3468	outer membrane autotransporter barrel domain protein
C4C67_RS06125	COG5441	Belongs to the UPF0261 family
C4C67_RS06130	COG5564	TIM-barrel signal transduction protein
C4C67_RS06145	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C4C67_RS06160	COG1477	protein flavinylation
C4C67_RS06180	COG1131	(ABC) transporter
C4C67_RS06185	COG0842	Transport permease protein
C4C67_RS06195	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C4C67_RS06200	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
C4C67_RS06200	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
C4C67_RS06205	COG1562	ergosterol biosynthetic process
C4C67_RS06210	COG1562	ergosterol biosynthetic process
C4C67_RS06215	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C4C67_RS06220	COG1028	Short-chain dehydrogenase reductase Sdr
C4C67_RS06240	COG2304	oxidoreductase activity
C4C67_RS06260	COG0534	Mate efflux family protein
C4C67_RS06270	COG0254	rRNA binding
C4C67_RS06275	COG3483	tryptophan 2,3-dioxygenase activity
C4C67_RS06280	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C4C67_RS06285	COG2003	Belongs to the UPF0758 family
C4C67_RS06290	COG1047	Peptidyl-prolyl cis-trans
C4C67_RS06295	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C4C67_RS06300	COG0625	glutathione transferase activity
C4C67_RS06320	COG0523	cobalamin synthesis protein
C4C67_RS06330	COG0583	DNA-binding transcription factor activity
C4C67_RS06340	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C4C67_RS06345	COG1187	pseudouridine synthase activity
C4C67_RS06350	COG0779	Required for maturation of 30S ribosomal subunits
C4C67_RS06355	COG0195	Participates in both transcription termination and antitermination
C4C67_RS06355	COG2251	uridine kinase activity
C4C67_RS06360	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C4C67_RS06365	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C4C67_RS06370	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C4C67_RS06390	COG1611	Belongs to the LOG family
C4C67_RS06405	COG0412	Dienelactone hydrolase
C4C67_RS06410	COG1283	sodium-dependent phosphate transmembrane transporter activity
C4C67_RS06415	COG1760	l-serine dehydratase
C4C67_RS06420	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C4C67_RS06425	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C4C67_RS06435	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C4C67_RS06460	COG2311	Membrane
C4C67_RS06485	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C4C67_RS06505	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4C67_RS06525	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C4C67_RS06535	COG1653	transport
C4C67_RS06540	COG1175	transmembrane transport
C4C67_RS06545	COG0395	ABC-type sugar transport system, permease component
C4C67_RS06550	COG3842	ATPase activity
C4C67_RS06575	COG2363	Small membrane protein
C4C67_RS06590	COG1464	Belongs to the NlpA lipoprotein family
C4C67_RS06600	COG0688	phosphatidylethanolamine metabolic process
C4C67_RS06615	COG0095	Lipoate-protein ligase
C4C67_RS06630	COG0625	glutathione transferase activity
C4C67_RS06635	COG0386	Belongs to the glutathione peroxidase family
C4C67_RS06655	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4C67_RS06685	COG2259	Doxx family
C4C67_RS06700	COG0667	Aldo Keto reductase
C4C67_RS06730	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C4C67_RS06750	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4C67_RS06760	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4C67_RS06810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4C67_RS06815	COG3568	Endonuclease Exonuclease Phosphatase
C4C67_RS06825	COG1695	Transcriptional regulator
C4C67_RS06845	COG0583	DNA-binding transcription factor activity
C4C67_RS06860	COG1802	Transcriptional regulator
C4C67_RS06870	COG3181	Tripartite tricarboxylate transporter family receptor
C4C67_RS06880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4C67_RS06895	COG0066	3-isopropylmalate dehydratase activity
C4C67_RS06905	COG3181	Tripartite tricarboxylate transporter family receptor
C4C67_RS06910	COG4948	Mandelate Racemase Muconate Lactonizing
C4C67_RS06925	COG1126	abc transporter atp-binding protein
C4C67_RS06930	COG0765	amino acid transport
C4C67_RS06935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4C67_RS06975	COG1815	bacterial-type flagellum-dependent cell motility
C4C67_RS06980	COG1558	bacterial-type flagellum-dependent cell motility
C4C67_RS06990	COG1749	Flagellar hook protein flgE
C4C67_RS07005	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C4C67_RS07010	COG1706	bacterial-type flagellum-dependent cell motility
C4C67_RS07020	COG1256	bacterial-type flagellum assembly
C4C67_RS07030	COG0840	transmembrane signaling receptor activity
C4C67_RS07035	COG0840	transmembrane signaling receptor activity
C4C67_RS07040	COG0840	transmembrane signaling receptor activity
C4C67_RS07060	COG1338	Plays a role in the flagellum-specific transport system
C4C67_RS07080	COG1580	Controls the rotational direction of flagella during chemotaxis
C4C67_RS07105	COG1157	protein secretion by the type III secretion system
C4C67_RS07110	COG1317	bacterial-type flagellum organization
C4C67_RS07115	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C4C67_RS07125	COG1677	Flagellar hook-basal body complex protein FliE
C4C67_RS07135	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C4C67_RS07170	COG0285	dihydrofolate synthase activity
C4C67_RS07200	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C4C67_RS07205	COG0024	Methionine aminopeptidase
C4C67_RS07210	COG0052	Belongs to the universal ribosomal protein uS2 family
C4C67_RS07215	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C4C67_RS07220	COG0528	UMP kinase activity
C4C67_RS07225	COG0233	cytoplasmic translational termination
C4C67_RS07230	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4C67_RS07240	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C4C67_RS07245	COG0750	zinc metalloprotease
C4C67_RS07250	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4C67_RS07255	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
C4C67_RS07260	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4C67_RS07265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4C67_RS07275	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4C67_RS07280	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C4C67_RS07285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4C67_RS07290	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C4C67_RS07300	COG0519	Catalyzes the synthesis of GMP from XMP
C4C67_RS07300	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4C67_RS07315	COG0330	HflC and HflK could
C4C67_RS07320	COG3706	GGDEF domain
C4C67_RS07325	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C4C67_RS07335	COG2867	negative regulation of translational initiation
C4C67_RS07345	COG1960	acyl-CoA dehydrogenase activity
C4C67_RS07350	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C4C67_RS07385	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4C67_RS07390	COG0505	Belongs to the CarA family
C4C67_RS07395	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C4C67_RS07405	COG0406	alpha-ribazole phosphatase activity
C4C67_RS07415	COG3842	ATPase activity
C4C67_RS07435	COG5001	Diguanylate cyclase
C4C67_RS07440	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C4C67_RS07450	COG1763	Mo-molybdopterin cofactor biosynthetic process
C4C67_RS07455	COG0303	'Molybdopterin
C4C67_RS07460	COG0746	molybdenum cofactor guanylyltransferase activity
C4C67_RS07465	COG0489	protein tyrosine kinase activity
C4C67_RS07495	COG0243	molybdopterin cofactor binding
C4C67_RS07495	COG3383	formate dehydrogenase (NAD+) activity
C4C67_RS07530	COG1122	ATPase activity
C4C67_RS07540	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C4C67_RS07545	COG0066	3-isopropylmalate dehydratase activity
C4C67_RS07550	COG0473	3-isopropylmalate dehydrogenase activity
C4C67_RS07555	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C4C67_RS07565	COG0101	tRNA pseudouridine synthase activity
C4C67_RS07570	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C4C67_RS07585	COG0135	phosphoribosylanthranilate isomerase activity
C4C67_RS07600	COG3022	response to hydroperoxide
C4C67_RS07640	COG2197	response regulator
C4C67_RS07645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4C67_RS07650	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C4C67_RS07655	COG0189	ligase activity
C4C67_RS07665	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4C67_RS07670	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4C67_RS07685	COG2423	ornithine cyclodeaminase activity
C4C67_RS07695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4C67_RS07700	COG0765	amino acid transport
C4C67_RS07705	COG0765	amino acid transport
C4C67_RS07710	COG1126	abc transporter atp-binding protein
C4C67_RS07765	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C4C67_RS07775	COG2944	sequence-specific DNA binding
C4C67_RS07785	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4C67_RS07790	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C4C67_RS07795	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C4C67_RS07800	COG0009	L-threonylcarbamoyladenylate synthase
C4C67_RS07805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4C67_RS07810	COG1414	Transcriptional regulator
C4C67_RS07825	COG0765	amino acid transport
C4C67_RS07830	COG1126	abc transporter atp-binding protein
C4C67_RS07835	COG0028	Belongs to the TPP enzyme family
C4C67_RS07850	COG0028	Belongs to the TPP enzyme family
C4C67_RS07855	COG0583	DNA-binding transcription factor activity
C4C67_RS07860	COG4974	Belongs to the 'phage' integrase family
C4C67_RS07865	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C4C67_RS07870	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C4C67_RS07885	COG1686	Belongs to the peptidase S11 family
C4C67_RS07895	COG2814	Major facilitator Superfamily
C4C67_RS07905	COG1074	ATP-dependent DNA helicase activity
C4C67_RS07915	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C4C67_RS07920	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C4C67_RS07925	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C4C67_RS07950	COG2321	neutral zinc metallopeptidase
C4C67_RS07955	COG0009	L-threonylcarbamoyladenylate synthase
C4C67_RS08000	COG3360	Dodecin
C4C67_RS08005	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C4C67_RS08010	COG2850	peptidyl-arginine hydroxylation
C4C67_RS08015	COG3539	Fimbrial protein
C4C67_RS08020	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C4C67_RS08025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4C67_RS08040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4C67_RS08045	COG0765	amino acid transport
C4C67_RS08050	COG1126	abc transporter atp-binding protein
C4C67_RS08055	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4C67_RS08060	COG1758	RNA polymerase activity
C4C67_RS08065	COG0194	GDP metabolic process
C4C67_RS08070	COG3258	Cytochrome c
C4C67_RS08075	COG2863	cytochrome
C4C67_RS08080	COG1028	Short-chain dehydrogenase reductase Sdr
C4C67_RS08085	COG0791	NLP P60 protein
C4C67_RS08090	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4C67_RS08110	COG1561	YicC-like family, N-terminal region
C4C67_RS08115	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C4C67_RS08135	COG2200	EAL domain
C4C67_RS08135	COG2199	diguanylate cyclase activity
C4C67_RS08140	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C4C67_RS08150	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4C67_RS08155	COG0174	glutamine synthetase
C4C67_RS08165	COG2204	response regulator
C4C67_RS08170	COG0583	DNA-binding transcription factor activity
C4C67_RS08175	COG1741	Belongs to the pirin family
C4C67_RS08180	COG1741	Belongs to the pirin family
C4C67_RS08190	COG3842	ATPase activity
C4C67_RS08195	COG1178	ABC-type Fe3 transport system permease component
C4C67_RS08200	COG1840	ABC-type Fe3 transport system, periplasmic component
C4C67_RS08210	COG0583	DNA-binding transcription factor activity
C4C67_RS08220	COG0656	L-ascorbic acid biosynthetic process
C4C67_RS08235	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C4C67_RS08240	COG0583	DNA-binding transcription factor activity
C4C67_RS08255	COG0783	Belongs to the Dps family
C4C67_RS08275	COG0463	Glycosyl transferase, family 2
C4C67_RS08295	COG0438	transferase activity, transferring glycosyl groups
C4C67_RS08310	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C4C67_RS08335	COG0300	oxidoreductase activity
C4C67_RS08380	COG0861	Integral membrane protein TerC family
C4C67_RS08385	COG1028	Short-chain dehydrogenase reductase Sdr
C4C67_RS08405	COG0714	Associated with various cellular activities
C4C67_RS08440	COG3119	arylsulfatase activity
C4C67_RS08465	COG2197	response regulator
C4C67_RS08475	COG2944	sequence-specific DNA binding
C4C67_RS08485	COG0625	glutathione transferase activity
C4C67_RS08515	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4C67_RS08520	COG1028	Short-chain dehydrogenase reductase Sdr
C4C67_RS08565	COG0431	NADPH-dependent FMN reductase
C4C67_RS08595	COG1028	Short-chain dehydrogenase reductase Sdr
C4C67_RS08600	COG0583	DNA-binding transcription factor activity
C4C67_RS08620	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C4C67_RS08620	COG2111	Na H antiporter
C4C67_RS08625	COG1006	Multisubunit Na H antiporter MnhC subunit
C4C67_RS08630	COG0651	ATP synthesis coupled electron transport
C4C67_RS08635	COG1863	multisubunit Na H antiporter MnhE subunit
C4C67_RS08640	COG2212	antiporter activity
C4C67_RS08665	COG0590	tRNA wobble adenosine to inosine editing
C4C67_RS08670	COG1619	proteins homologs of microcin C7 resistance protein MccF
C4C67_RS08675	COG1024	Enoyl-CoA hydratase
C4C67_RS08690	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C4C67_RS08695	COG0488	(ABC) transporter
C4C67_RS08730	COG1017	nitric oxide dioxygenase activity
C4C67_RS08730	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4C67_RS08735	COG1959	2 iron, 2 sulfur cluster binding
C4C67_RS08740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4C67_RS08760	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C4C67_RS08765	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4C67_RS08770	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C4C67_RS08775	COG0084	hydrolase, TatD family'
C4C67_RS08790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4C67_RS08800	COG1126	abc transporter atp-binding protein
C4C67_RS08810	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C4C67_RS08825	COG0028	Belongs to the TPP enzyme family
C4C67_RS08835	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C4C67_RS08835	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C4C67_RS08845	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C4C67_RS08895	COG4336	lyase activity
C4C67_RS08905	COG2205	protein histidine kinase activity
C4C67_RS08905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4C67_RS08910	COG2197	response regulator
C4C67_RS08915	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
C4C67_RS08915	COG3210	domain, Protein
C4C67_RS08915	COG3064	Membrane
C4C67_RS08925	COG3121	Chaperone
C4C67_RS08930	COG3188	usher protein
C4C67_RS08935	COG3539	Fimbrial protein
C4C67_RS08940	COG2831	hemolysin activation secretion protein
C4C67_RS08955	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C4C67_RS09005	COG0668	transmembrane transport
C4C67_RS09025	COG0483	inositol monophosphate 1-phosphatase activity
C4C67_RS09030	COG1253	flavin adenine dinucleotide binding
C4C67_RS09035	COG1968	undecaprenyl-diphosphatase activity
C4C67_RS09040	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4C67_RS09055	COG0215	cysteine-tRNA ligase activity
C4C67_RS09065	COG0825	malonyl-CoA metabolic process
C4C67_RS09075	COG0037	tRNA processing
C4C67_RS09080	COG0527	aspartate kinase activity
C4C67_RS09105	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4C67_RS09110	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C4C67_RS09110	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C4C67_RS09125	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4C67_RS09130	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
C4C67_RS09135	COG1028	Short-chain dehydrogenase reductase Sdr
C4C67_RS09145	COG0583	DNA-binding transcription factor activity
C4C67_RS09170	COG3842	ATPase activity
C4C67_RS09180	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4C67_RS09180	COG1902	pentaerythritol trinitrate reductase activity
C4C67_RS09185	COG1414	Transcriptional regulator
C4C67_RS09190	COG1832	CoA-binding protein
C4C67_RS09200	COG0251	oxidation-reduction process
C4C67_RS09225	COG1902	pentaerythritol trinitrate reductase activity
C4C67_RS09235	COG1215	transferase activity, transferring glycosyl groups
C4C67_RS09240	COG1649	PFAM Uncharacterised BCR, COG1649
C4C67_RS09240	COG0726	polysaccharide deacetylase
C4C67_RS09260	COG1846	Transcriptional regulator
C4C67_RS09265	COG2197	response regulator
C4C67_RS09280	COG0166	Belongs to the GPI family
C4C67_RS09285	COG1045	serine acetyltransferase
C4C67_RS09295	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C4C67_RS09300	COG0483	inositol monophosphate 1-phosphatase activity
C4C67_RS09305	COG1012	belongs to the aldehyde dehydrogenase family
C4C67_RS09310	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4C67_RS09325	COG0210	DNA helicase
C4C67_RS09330	COG0598	Magnesium transport protein CorA
C4C67_RS09340	COG0747	negative chemotaxis
C4C67_RS09345	COG0601	transmembrane transport
C4C67_RS09350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4C67_RS09355	COG4172	Belongs to the ABC transporter superfamily
C4C67_RS09360	COG1846	Transcriptional regulator
C4C67_RS09415	COG4964	Belongs to the GSP D family
C4C67_RS09455	COG2204	response regulator
C4C67_RS09470	COG1595	DNA-templated transcription, initiation
C4C67_RS09480	COG3474	cytochrome
C4C67_RS09485	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C4C67_RS09500	COG3384	dioxygenase
C4C67_RS09505	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C4C67_RS09535	COG2885	chlorophyll binding
C4C67_RS09570	COG0697	spore germination
C4C67_RS09575	COG0730	response to heat
C4C67_RS09595	COG0583	DNA-binding transcription factor activity
C4C67_RS09600	COG0427	acetyl-CoA hydrolase
C4C67_RS09655	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4C67_RS09660	COG0154	amidase activity
C4C67_RS09670	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C4C67_RS09685	COG0495	leucyl-tRNA aminoacylation
C4C67_RS09690	COG2814	Major facilitator Superfamily
C4C67_RS09725	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4C67_RS09730	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C4C67_RS09735	COG2814	Major facilitator Superfamily
C4C67_RS09755	COG4176	ABC-type proline glycine betaine transport system permease component
C4C67_RS09765	COG1942	4-Oxalocrotonate Tautomerase
C4C67_RS09770	COG0183	Belongs to the thiolase family
C4C67_RS09780	COG1802	Transcriptional regulator
C4C67_RS09790	COG1024	Enoyl-CoA hydratase
C4C67_RS09805	COG2032	superoxide dismutase activity
C4C67_RS09820	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C4C67_RS09845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4C67_RS09850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4C67_RS09860	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C4C67_RS09865	COG0736	holo-[acyl-carrier-protein] synthase activity
C4C67_RS09870	COG1472	Belongs to the glycosyl hydrolase 3 family
C4C67_RS09875	COG0322	excinuclease ABC activity
C4C67_RS09880	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C4C67_RS09890	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4C67_RS09890	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4C67_RS09895	COG2224	Isocitrate lyase
C4C67_RS09915	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4C67_RS09925	COG4638	Rieske (2fe-2S)
C4C67_RS09935	COG1024	Enoyl-CoA hydratase
C4C67_RS09945	COG0633	Ferredoxin
C4C67_RS09950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4C67_RS09965	COG0183	Belongs to the thiolase family
C4C67_RS09980	COG0583	DNA-binding transcription factor activity
C4C67_RS10010	COG2346	COG2346, Truncated hemoglobins
C4C67_RS10140	COG2207	Transcriptional regulator
C4C67_RS10190	COG1132	(ABC) transporter
C4C67_RS10215	COG0659	secondary active sulfate transmembrane transporter activity
C4C67_RS10245	COG2169	Transcriptional regulator
C4C67_RS10250	COG5507	3-demethylubiquinone-9 3-methyltransferase
C4C67_RS10255	COG0384	phenazine biosynthesis protein PhzF
C4C67_RS10260	COG0583	DNA-binding transcription factor activity
C4C67_RS10265	COG2733	membrane
C4C67_RS10280	COG1012	belongs to the aldehyde dehydrogenase family
C4C67_RS10285	COG3284	Transcriptional regulator
C4C67_RS10310	COG1380	Effector of murein hydrolase LrgA
C4C67_RS10315	COG4106	trans-aconitate 2-methyltransferase activity
C4C67_RS10315	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C4C67_RS10325	COG0156	8-amino-7-oxononanoate synthase activity
C4C67_RS10395	COG1131	(ABC) transporter
C4C67_RS10400	COG0842	Transport permease protein
C4C67_RS10405	COG0628	permease
C4C67_RS10440	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4C67_RS10455	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C4C67_RS10460	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C4C67_RS10465	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C4C67_RS10470	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C4C67_RS10475	COG0330	HflC and HflK could
C4C67_RS10480	COG0330	HflC and HflK could
C4C67_RS10485	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C4C67_RS10490	COG1923	regulation of RNA biosynthetic process
C4C67_RS10495	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4C67_RS10500	COG1160	GTP binding
C4C67_RS10505	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4C67_RS10510	COG2976	Protein conserved in bacteria
C4C67_RS10515	COG0124	histidyl-tRNA synthetase
C4C67_RS10520	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C4C67_RS10530	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C4C67_RS10535	COG0105	UTP biosynthetic process
C4C67_RS10540	COG0525	valine-tRNA ligase activity
C4C67_RS10555	COG0642	Histidine kinase
C4C67_RS10580	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4C67_RS10585	COG0336	Belongs to the RNA methyltransferase TrmD family
C4C67_RS10590	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C4C67_RS10595	COG0228	four-way junction DNA binding
C4C67_RS10605	COG0425	Belongs to the sulfur carrier protein TusA family
C4C67_RS10610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4C67_RS10655	COG0154	amidase activity
C4C67_RS10660	COG4172	Belongs to the ABC transporter superfamily
C4C67_RS10665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4C67_RS10670	COG0601	transmembrane transport
C4C67_RS10675	COG0747	negative chemotaxis
C4C67_RS10705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4C67_RS10715	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C4C67_RS10735	COG3395	kinase activity
C4C67_RS10750	COG1024	Enoyl-CoA hydratase
C4C67_RS10770	COG0633	Ferredoxin
C4C67_RS10775	COG0443	Heat shock 70 kDa protein
C4C67_RS10780	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C4C67_RS10785	COG0316	Belongs to the HesB IscA family
C4C67_RS10790	COG0822	iron-sulfur transferase activity
C4C67_RS10795	COG1104	cysteine desulfurase activity
C4C67_RS10805	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4C67_RS10810	COG0556	nucleotide-excision repair
C4C67_RS10820	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4C67_RS10850	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C4C67_RS10870	COG1028	Short-chain dehydrogenase reductase Sdr
C4C67_RS10875	COG0183	Belongs to the thiolase family
C4C67_RS10885	COG1024	Enoyl-CoA hydratase
C4C67_RS10900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4C67_RS10905	COG0583	DNA-binding transcription factor activity
C4C67_RS10910	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4C67_RS10915	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C4C67_RS10920	COG0740	serine-type endopeptidase activity
C4C67_RS10925	COG0544	peptidyl-prolyl cis-trans isomerase activity
C4C67_RS10935	COG1278	Cold shock
C4C67_RS10945	COG1278	Cold shock
C4C67_RS10980	COG2171	N-acyltransferase activity
C4C67_RS10985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4C67_RS10990	COG2890	protein-(glutamine-N5) methyltransferase activity
C4C67_RS10995	COG0488	(ABC) transporter
C4C67_RS11000	COG4771	TonB-dependent receptor
C4C67_RS11005	COG0210	DNA helicase
C4C67_RS11025	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C4C67_RS11030	COG0196	riboflavin kinase activity
C4C67_RS11035	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C4C67_RS11040	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C4C67_RS11045	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C4C67_RS11055	COG1522	sequence-specific DNA binding
C4C67_RS11075	COG2951	lytic endotransglycosylase activity
C4C67_RS11080	COG2833	Protein of unknown function (DUF455)
C4C67_RS11100	COG0189	ligase activity
C4C67_RS11100	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4C67_RS11105	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4C67_RS11105	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4C67_RS11110	COG3237	CsbD-like
C4C67_RS11120	COG2823	Periplasmic or secreted lipoprotein
C4C67_RS11145	COG4181	ATPase activity
C4C67_RS11155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4C67_RS11160	COG0584	glycerophosphoryl diester phosphodiesterase
C4C67_RS11165	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C4C67_RS11175	COG0678	peroxiredoxin activity
C4C67_RS11175	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C4C67_RS11185	COG0789	Transcriptional regulator
C4C67_RS11190	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4C67_RS11220	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C4C67_RS11225	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C4C67_RS11235	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C4C67_RS11240	COG2252	PERMEase
C4C67_RS11250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4C67_RS11280	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C4C67_RS11285	COG2358	TRAP transporter, solute receptor (TAXI family
C4C67_RS11320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4C67_RS11325	COG1366	Belongs to the anti-sigma-factor antagonist family
C4C67_RS11330	COG2172	sigma factor antagonist activity
C4C67_RS11335	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C4C67_RS11345	COG2770	Histidine kinase
C4C67_RS11345	COG2208	phosphoserine phosphatase activity
C4C67_RS11370	COG1595	DNA-templated transcription, initiation
C4C67_RS11385	COG4792	protein secretion
C4C67_RS11390	COG4791	protein targeting
C4C67_RS11395	COG4794	Type iii secretion
C4C67_RS11400	COG4790	Type iii secretion
C4C67_RS11435	COG4669	(LipO)protein
C4C67_RS11500	COG4789	Type iii secretion
C4C67_RS11530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4C67_RS11535	COG0840	transmembrane signaling receptor activity
C4C67_RS11540	COG2233	PERMEase
C4C67_RS11570	COG1840	ABC-type Fe3 transport system, periplasmic component
C4C67_RS11575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4C67_RS11580	COG1178	ABC-type Fe3 transport system permease component
C4C67_RS11585	COG3842	ATPase activity
C4C67_RS11590	COG0583	DNA-binding transcription factor activity
C4C67_RS11610	COG0501	Belongs to the peptidase M48B family
C4C67_RS11620	COG0697	spore germination
C4C67_RS11630	COG1846	Transcriptional regulator
C4C67_RS11640	COG1566	PFAM secretion protein HlyD family protein
C4C67_RS11645	COG2814	Major facilitator Superfamily
C4C67_RS11650	COG0473	3-isopropylmalate dehydrogenase activity
C4C67_RS11660	COG0747	negative chemotaxis
C4C67_RS11670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4C67_RS11685	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4C67_RS11710	COG1012	belongs to the aldehyde dehydrogenase family
C4C67_RS11720	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C4C67_RS11725	COG1115	amino acid carrier protein
C4C67_RS11730	COG0433	COG0433 Predicted ATPase
C4C67_RS11735	COG0217	transcriptional regulatory protein
C4C67_RS11740	COG0151	Belongs to the GarS family
C4C67_RS11745	COG0408	coproporphyrinogen oxidase activity
C4C67_RS11750	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C4C67_RS11755	COG0799	negative regulation of ribosome biogenesis
C4C67_RS11760	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C4C67_RS11765	COG0424	maF-like protein
C4C67_RS11770	COG3468	outer membrane autotransporter barrel domain protein
C4C67_RS11810	COG1530	ribonuclease E activity
C4C67_RS11815	COG0077	Prephenate dehydratase
C4C67_RS11830	COG1132	(ABC) transporter
C4C67_RS11835	COG0859	PFAM glycosyl transferase family 9
C4C67_RS11860	COG2194	sulfuric ester hydrolase activity
C4C67_RS11865	COG0438	transferase activity, transferring glycosyl groups
C4C67_RS11870	COG0463	Glycosyl transferase, family 2
C4C67_RS11875	COG0726	polysaccharide deacetylase
C4C67_RS11880	COG0438	transferase activity, transferring glycosyl groups
C4C67_RS11895	COG1643	Atp-dependent helicase
C4C67_RS11900	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4C67_RS11900	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C4C67_RS11905	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C4C67_RS11915	COG0704	Plays a role in the regulation of phosphate uptake
C4C67_RS11920	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C4C67_RS11925	COG1960	acyl-CoA dehydrogenase activity
C4C67_RS11950	COG1177	transmembrane transport
C4C67_RS11955	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4C67_RS11960	COG3842	ATPase activity
C4C67_RS11965	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C4C67_RS11980	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C4C67_RS11985	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C4C67_RS11995	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C4C67_RS11995	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C4C67_RS12010	COG0372	Belongs to the citrate synthase family
C4C67_RS12015	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C4C67_RS12020	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C4C67_RS12025	COG1053	succinate dehydrogenase
C4C67_RS12030	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C4C67_RS12035	COG2009	succinate dehydrogenase
C4C67_RS12040	COG2188	Transcriptional regulator
C4C67_RS12045	COG0039	L-malate dehydrogenase activity
C4C67_RS12075	COG1981	membrane
C4C67_RS12100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4C67_RS12110	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C4C67_RS12140	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C4C67_RS12145	COG0148	phosphopyruvate hydratase activity
C4C67_RS12155	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C4C67_RS12160	COG0504	CTP synthase activity
C4C67_RS12185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4C67_RS12195	COG0747	negative chemotaxis
C4C67_RS12200	COG4172	Belongs to the ABC transporter superfamily
C4C67_RS12205	COG1446	asparaginase
C4C67_RS12235	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C4C67_RS12250	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C4C67_RS12255	COG0697	spore germination
C4C67_RS12260	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4C67_RS12270	COG3193	protein, possibly involved in utilization of glycolate and propanediol
C4C67_RS12280	COG0791	NLP P60 protein
C4C67_RS12295	COG0583	DNA-binding transcription factor activity
C4C67_RS12310	COG0583	DNA-binding transcription factor activity
C4C67_RS12320	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C4C67_RS12335	COG0670	Belongs to the BI1 family
C4C67_RS12340	COG3181	Tripartite tricarboxylate transporter family receptor
C4C67_RS12355	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4C67_RS12365	COG1381	Involved in DNA repair and RecF pathway recombination
C4C67_RS12370	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C4C67_RS12375	COG0571	ribonuclease III activity
C4C67_RS12380	COG0681	Belongs to the peptidase S26 family
C4C67_RS12385	COG0481	GTPase activity
C4C67_RS12390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4C67_RS12415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4C67_RS12420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4C67_RS12435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4C67_RS12440	COG0416	fatty acid biosynthetic process
C4C67_RS12445	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C4C67_RS12450	COG1399	metal-binding, possibly nucleic acid-binding protein
C4C67_RS12455	COG0424	maF-like protein
C4C67_RS12465	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4C67_RS12480	COG3022	response to hydroperoxide
C4C67_RS12490	COG1028	Short-chain dehydrogenase reductase Sdr
C4C67_RS12505	COG3486	L-lysine 6-monooxygenase (NADPH) activity
C4C67_RS12535	COG2814	Major facilitator Superfamily
C4C67_RS12555	COG3706	GGDEF domain
C4C67_RS12580	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4C67_RS12585	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C4C67_RS12590	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C4C67_RS12595	COG1674	ftsk spoiiie
C4C67_RS12600	COG0492	ferredoxin-NADP+ reductase activity
C4C67_RS12605	COG1193	negative regulation of DNA recombination
C4C67_RS12625	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4C67_RS12640	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C4C67_RS12645	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C4C67_RS12650	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C4C67_RS12660	COG0745	RESPONSE REGULATOR receiver
C4C67_RS12705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C4C67_RS12725	COG0612	Peptidase, M16
C4C67_RS12735	COG0443	Heat shock 70 kDa protein
C4C67_RS12745	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C4C67_RS12755	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C4C67_RS12760	COG1420	regulation of RNA biosynthetic process
C4C67_RS12765	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C4C67_RS12770	COG0497	DNA recombination
C4C67_RS12775	COG0735	belongs to the Fur family
C4C67_RS12780	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4C67_RS12785	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C4C67_RS12790	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C4C67_RS12825	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4C67_RS12825	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4C67_RS12830	COG4311	Sarcosine oxidase, delta subunit
C4C67_RS12835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4C67_RS12845	COG0583	DNA-binding transcription factor activity
C4C67_RS12855	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4C67_RS12880	COG4964	Belongs to the GSP D family
C4C67_RS12940	COG0181	hydroxymethylbilane synthase activity
C4C67_RS12945	COG0861	Integral membrane protein TerC family
C4C67_RS12950	COG0861	Integral membrane protein TerC family
C4C67_RS12955	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C4C67_RS12960	COG0045	succinate-CoA ligase (ADP-forming) activity
C4C67_RS12970	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C4C67_RS12980	COG2137	regulation of response to DNA damage stimulus
C4C67_RS12985	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C4C67_RS13005	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4C67_RS13005	COG1024	Enoyl-CoA hydratase
C4C67_RS13010	COG3842	ATPase activity
C4C67_RS13025	COG1028	Short-chain dehydrogenase reductase Sdr
C4C67_RS13045	COG0583	DNA-binding transcription factor activity
C4C67_RS13050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4C67_RS13060	COG2974	May be involved in recombination
C4C67_RS13065	COG0540	Belongs to the ATCase OTCase family
C4C67_RS13130	COG0776	regulation of translation
C4C67_RS13135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4C67_RS13135	COG0072	phenylalanine-tRNA ligase activity
C4C67_RS13140	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C4C67_RS13145	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C4C67_RS13150	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C4C67_RS13160	COG0756	dUTP diphosphatase activity
C4C67_RS13170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4C67_RS13185	COG0500	methyltransferase
C4C67_RS13200	COG0586	Pfam SNARE associated Golgi protein
C4C67_RS13230	COG1609	Transcriptional regulator
C4C67_RS13235	COG4172	Belongs to the ABC transporter superfamily
C4C67_RS13240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4C67_RS13245	COG0601	transmembrane transport
C4C67_RS13250	COG0747	negative chemotaxis
C4C67_RS13270	COG1280	lysine exporter protein (LysE YggA)
C4C67_RS13285	COG2814	Major facilitator Superfamily
C4C67_RS13315	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C4C67_RS13335	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C4C67_RS13370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4C67_RS13375	COG1116	anion transmembrane transporter activity
C4C67_RS13385	COG1228	amidohydrolase
C4C67_RS13400	COG0477	Major facilitator Superfamily
C4C67_RS13410	COG3550	peptidyl-serine autophosphorylation
C4C67_RS13425	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4C67_RS13425	COG0519	Catalyzes the synthesis of GMP from XMP
C4C67_RS13470	COG0420	3'-5' exonuclease activity
C4C67_RS13475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4C67_RS13505	COG0395	ABC-type sugar transport system, permease component
C4C67_RS13515	COG3842	ATPase activity
C4C67_RS13540	COG3181	Tripartite tricarboxylate transporter family receptor
C4C67_RS13575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4C67_RS13600	COG0602	queuosine metabolic process
C4C67_RS13605	COG0720	synthase
C4C67_RS13610	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C4C67_RS13615	COG0235	Class ii aldolase
C4C67_RS13645	COG3210	domain, Protein
C4C67_RS13645	COG3064	Membrane
C4C67_RS13645	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
C4C67_RS13650	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4C67_RS13650	COG0047	phosphoribosylformylglycinamidine synthase activity
C4C67_RS13655	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C4C67_RS13660	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C4C67_RS13660	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C4C67_RS13665	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C4C67_RS13685	COG3539	Fimbrial protein
C4C67_RS13695	COG2050	protein possibly involved in aromatic compounds catabolism
C4C67_RS13700	COG1024	Enoyl-CoA hydratase
C4C67_RS13705	COG1012	belongs to the aldehyde dehydrogenase family
C4C67_RS13725	COG2151	metal-sulfur cluster biosynthetic enzyme
C4C67_RS13730	COG3396	Phenylacetate-CoA oxygenase
C4C67_RS13735	COG3460	Phenylacetate-CoA oxygenase
C4C67_RS13740	COG3396	Phenylacetate-CoA oxygenase
C4C67_RS13745	COG3327	negative regulation of DNA-templated transcription, initiation
C4C67_RS13755	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C4C67_RS13760	COG0501	Belongs to the peptidase M48B family
C4C67_RS13765	COG1162	GTPase activity
C4C67_RS13780	COG0601	transmembrane transport
C4C67_RS13785	COG0747	negative chemotaxis
C4C67_RS13830	COG0668	transmembrane transport
C4C67_RS13835	COG0165	Argininosuccinate lyase
C4C67_RS13855	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4C67_RS13860	COG0303	'Molybdopterin
C4C67_RS13865	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4C67_RS13880	COG0315	cyclic pyranopterin monophosphate synthase activity
C4C67_RS13890	COG0412	Dienelactone hydrolase
C4C67_RS13900	COG0678	peroxiredoxin activity
C4C67_RS13910	COG0697	spore germination
C4C67_RS13915	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C4C67_RS13940	COG0789	Transcriptional regulator
C4C67_RS13960	COG1028	Short-chain dehydrogenase reductase Sdr
C4C67_RS13970	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C4C67_RS13975	COG1845	cytochrome c oxidase, subunit III
C4C67_RS13980	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4C67_RS13990	COG0477	Major facilitator Superfamily
C4C67_RS14025	COG1309	transcriptional regulator
C4C67_RS14030	COG2271	Major facilitator Superfamily
C4C67_RS14065	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4C67_RS14065	COG0506	proline dehydrogenase activity
C4C67_RS14065	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4C67_RS14075	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C4C67_RS14075	COG3008	intermembrane lipid transfer
C4C67_RS14080	COG2995	paraquat-inducible protein a
C4C67_RS14085	COG0542	response to heat
C4C67_RS14090	COG4953	penicillin-binding protein 1C
C4C67_RS14100	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C4C67_RS14105	COG1278	Cold shock
C4C67_RS14115	COG0183	Belongs to the thiolase family
C4C67_RS14120	COG0038	chloride channel
C4C67_RS14125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C4C67_RS14130	COG1570	exodeoxyribonuclease VII activity
C4C67_RS14140	COG0811	peptide transport
C4C67_RS14145	COG0848	biopolymer transport protein
C4C67_RS14150	COG1663	tetraacyldisaccharide 4'-kinase activity
C4C67_RS14155	COG2835	tetraacyldisaccharide 4'-kinase activity
C4C67_RS14160	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C4C67_RS14165	COG0563	adenylate kinase activity
C4C67_RS14175	COG0728	peptidoglycan biosynthetic process
C4C67_RS14185	COG0268	Binds directly to 16S ribosomal RNA
C4C67_RS14220	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C4C67_RS14245	COG0436	Aminotransferase
C4C67_RS14250	COG3737	Protein of unknown function (DUF498/DUF598)
C4C67_RS14255	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C4C67_RS14260	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C4C67_RS14265	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C4C67_RS14275	COG0305	Participates in initiation and elongation during chromosome replication
C4C67_RS14285	COG0359	binds to the 23S rRNA
C4C67_RS14290	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C4C67_RS14295	COG2965	DNA replication, synthesis of RNA primer
C4C67_RS14300	COG0360	Binds together with S18 to 16S ribosomal RNA
C4C67_RS14305	COG1469	GTP cyclohydrolase I activity
C4C67_RS14310	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C4C67_RS14315	COG0142	geranyltranstransferase activity
C4C67_RS14320	COG1722	exodeoxyribonuclease VII activity
C4C67_RS14330	COG3181	Tripartite tricarboxylate transporter family receptor
C4C67_RS14350	COG2239	Acts as a magnesium transporter
C4C67_RS14360	COG2855	membrane
C4C67_RS14370	COG1473	amidohydrolase
C4C67_RS14375	COG0318	PFAM AMP-dependent synthetase and ligase
C4C67_RS14400	COG1501	Belongs to the glycosyl hydrolase 31 family
C4C67_RS14405	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4C67_RS14410	COG2011	ABC-type metal ion transport system permease component
C4C67_RS14430	COG1454	alcohol dehydrogenase
C4C67_RS14460	COG2186	Transcriptional regulator
C4C67_RS14465	COG3181	Tripartite tricarboxylate transporter family receptor
C4C67_RS14485	COG1175	transmembrane transport
C4C67_RS14490	COG0395	ABC-type sugar transport system, permease component
C4C67_RS14495	COG3842	ATPase activity
C4C67_RS14510	COG1653	transport
C4C67_RS14530	COG2818	Glycosylase
C4C67_RS14535	COG2982	Protein involved in outer membrane biogenesis
C4C67_RS14545	COG1309	transcriptional regulator
C4C67_RS14550	COG1028	Short-chain dehydrogenase reductase Sdr
C4C67_RS14610	COG0583	DNA-binding transcription factor activity
C4C67_RS14615	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C4C67_RS14620	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C4C67_RS14635	COG1028	Short-chain dehydrogenase reductase Sdr
C4C67_RS14640	COG0477	Major facilitator Superfamily
C4C67_RS14650	COG0583	DNA-binding transcription factor activity
C4C67_RS14655	COG1448	Aminotransferase
C4C67_RS14660	COG1418	mRNA catabolic process
C4C67_RS14685	COG1063	alcohol dehydrogenase
C4C67_RS14705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4C67_RS14715	COG0318	PFAM AMP-dependent synthetase and ligase
C4C67_RS14725	COG1522	sequence-specific DNA binding
C4C67_RS14730	COG3181	Tripartite tricarboxylate transporter family receptor
C4C67_RS14735	COG0307	riboflavin synthase, alpha
C4C67_RS14740	COG0154	amidase activity
C4C67_RS14760	COG2807	transmembrane transport
C4C67_RS14765	COG0590	tRNA wobble adenosine to inosine editing
C4C67_RS14775	COG0583	DNA-binding transcription factor activity
C4C67_RS14810	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4C67_RS14815	COG0251	oxidation-reduction process
C4C67_RS14820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4C67_RS14830	COG1414	Transcriptional regulator
C4C67_RS14835	COG1028	Short-chain dehydrogenase reductase Sdr
C4C67_RS14850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4C67_RS14865	COG1024	Enoyl-CoA hydratase
C4C67_RS14870	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4C67_RS14875	COG0154	amidase activity
C4C67_RS14915	COG3909	cytochrome
C4C67_RS14920	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C4C67_RS14925	COG0625	glutathione transferase activity
C4C67_RS14930	COG0730	response to heat
C4C67_RS14935	COG0482	sulfurtransferase activity
C4C67_RS14940	COG0583	DNA-binding transcription factor activity
C4C67_RS14980	COG2819	hydrolase of the alpha beta superfamily
C4C67_RS14985	COG0247	lactate metabolic process
C4C67_RS14990	COG0277	FAD linked oxidase domain protein
C4C67_RS14995	COG0277	FAD linked oxidase domain protein
C4C67_RS15000	COG0277	FAD linked oxidase domain protein
C4C67_RS15005	COG3210	domain, Protein
C4C67_RS15005	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
C4C67_RS15005	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
C4C67_RS15005	COG3064	Membrane
C4C67_RS15005	COG3210	domain, Protein
C4C67_RS15005	COG3064	Membrane
C4C67_RS15010	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C4C67_RS15015	COG0312	modulator of DNA gyrase
C4C67_RS15050	COG1666	GTP binding
C4C67_RS15095	COG3220	belongs to the UPF0276 family
C4C67_RS15115	COG0640	Transcriptional regulator
C4C67_RS15120	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C4C67_RS15125	COG1845	cytochrome c oxidase, subunit III
C4C67_RS15130	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4C67_RS15140	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C4C67_RS15175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4C67_RS15180	COG0583	DNA-binding transcription factor activity
C4C67_RS15215	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4C67_RS15215	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4C67_RS15230	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4C67_RS15235	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4C67_RS15245	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C4C67_RS15260	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C4C67_RS15265	COG0316	Belongs to the HesB IscA family
C4C67_RS15275	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C4C67_RS15280	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C4C67_RS15285	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C4C67_RS15290	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C4C67_RS15295	COG0312	modulator of DNA gyrase
C4C67_RS15300	COG3028	Belongs to the UPF0307 family
C4C67_RS15315	COG1116	anion transmembrane transporter activity
C4C67_RS15320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4C67_RS15325	COG1335	isochorismatase
C4C67_RS15330	COG0346	lactoylglutathione lyase activity
C4C67_RS15335	COG0513	Belongs to the DEAD box helicase family
C4C67_RS15340	COG3069	C4-dicarboxylate transmembrane transporter activity
C4C67_RS15345	COG1802	Transcriptional regulator
C4C67_RS15360	COG0045	succinate-CoA ligase (ADP-forming) activity
C4C67_RS15360	COG1042	CoA-binding domain protein
C4C67_RS15360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4C67_RS15365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4C67_RS15380	COG1522	sequence-specific DNA binding
C4C67_RS15415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4C67_RS15420	COG1696	Membrane protein involved in D-alanine export
C4C67_RS15445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4C67_RS15460	COG0439	Biotin carboxylase
C4C67_RS15465	COG0511	ligase activity, forming carbon-carbon bonds
C4C67_RS15470	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4C67_RS15475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4C67_RS15480	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4C67_RS15485	COG3150	esterase
C4C67_RS15490	COG0557	exoribonuclease II activity
C4C67_RS15500	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4C67_RS15520	COG1522	sequence-specific DNA binding
C4C67_RS15525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4C67_RS15530	COG1028	Short-chain dehydrogenase reductase Sdr
C4C67_RS15550	COG0653	protein targeting
C4C67_RS15555	COG0739	heme binding
C4C67_RS15565	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C4C67_RS15570	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C4C67_RS15580	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C4C67_RS15585	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4C67_RS15590	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4C67_RS15595	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4C67_RS15605	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C4C67_RS15610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4C67_RS15615	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4C67_RS15625	COG3116	cell division
C4C67_RS15630	COG0275	rRNA processing
C4C67_RS15635	COG2001	Belongs to the MraZ family
C4C67_RS15645	COG0488	(ABC) transporter
C4C67_RS15650	COG0418	dihydroorotase activity
C4C67_RS15655	COG1473	amidohydrolase
C4C67_RS15705	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4C67_RS15710	COG4654	Cytochrome c, class I
C4C67_RS15715	COG0129	dihydroxy-acid dehydratase activity
C4C67_RS15720	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C4C67_RS15780	COG2084	Dehydrogenase
C4C67_RS15800	COG2096	Adenosyltransferase
C4C67_RS15815	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C4C67_RS15820	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C4C67_RS15830	COG0523	cobalamin synthesis protein
C4C67_RS15835	COG0735	belongs to the Fur family
C4C67_RS15850	COG0803	Belongs to the bacterial solute-binding protein 9 family
C4C67_RS15860	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C4C67_RS15870	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C4C67_RS15880	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4C67_RS15885	COG1560	Kdo2-lipid A biosynthetic process
C4C67_RS15895	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C4C67_RS15910	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C4C67_RS15915	COG1950	PFAM Membrane protein of
C4C67_RS15930	COG0583	DNA-binding transcription factor activity
C4C67_RS15940	COG0477	Major facilitator Superfamily
C4C67_RS15955	COG0617	tRNA 3'-terminal CCA addition
C4C67_RS15965	COG0513	Belongs to the DEAD box helicase family
C4C67_RS15970	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C4C67_RS15980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4C67_RS15985	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C4C67_RS16060	COG0405	Gamma-glutamyltransferase
C4C67_RS16070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4C67_RS16100	COG1309	transcriptional regulator
C4C67_RS16115	COG0745	RESPONSE REGULATOR receiver
C4C67_RS16165	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4C67_RS16190	COG0582	viral genome integration into host DNA
C4C67_RS16195	COG0012	GTP binding
C4C67_RS16205	COG0193	aminoacyl-tRNA hydrolase activity
C4C67_RS16210	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C4C67_RS16215	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4C67_RS16225	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C4C67_RS16230	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C4C67_RS16240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C4C67_RS16265	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C4C67_RS16275	COG1368	sulfuric ester hydrolase activity
C4C67_RS16280	COG0642	Histidine kinase
C4C67_RS16285	COG0745	RESPONSE REGULATOR receiver
C4C67_RS16290	COG0277	FAD linked oxidase domain protein
C4C67_RS16305	COG0166	Belongs to the GPI family
C4C67_RS16310	COG0438	transferase activity, transferring glycosyl groups
C4C67_RS16315	COG0438	transferase activity, transferring glycosyl groups
C4C67_RS16330	COG0438	transferase activity, transferring glycosyl groups
C4C67_RS16345	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C4C67_RS16350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4C67_RS16355	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C4C67_RS16365	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C4C67_RS16375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4C67_RS16380	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C4C67_RS16390	COG0747	negative chemotaxis
C4C67_RS16395	COG0601	transmembrane transport
C4C67_RS16400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4C67_RS16420	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C4C67_RS16425	COG0830	nickel cation binding
C4C67_RS16435	COG0804	urea catabolic process
C4C67_RS16440	COG0832	Belongs to the urease beta subunit family
C4C67_RS16450	COG0831	urea catabolic process
C4C67_RS16455	COG0829	nickel cation binding
C4C67_RS16485	COG2188	Transcriptional regulator
C4C67_RS16510	COG2719	SpoVR family
C4C67_RS16515	COG2718	Belongs to the UPF0229 family
C4C67_RS16535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4C67_RS16550	COG1960	acyl-CoA dehydrogenase activity
C4C67_RS16600	COG2030	dehydratase
C4C67_RS16665	COG0328	RNA-DNA hybrid ribonuclease activity
C4C67_RS16670	COG2226	methyltransferase
C4C67_RS16675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4C67_RS16680	COG1388	LysM domain
C4C67_RS16680	COG0741	lytic transglycosylase activity
C4C67_RS16700	COG2979	Protein of unknown function (DUF533)
C4C67_RS16735	COG1271	oxidase subunit
C4C67_RS16740	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4C67_RS16745	COG0850	regulation of cytokinetic process
C4C67_RS16750	COG2894	cell division
C4C67_RS16755	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C4C67_RS16790	COG0601	transmembrane transport
C4C67_RS16800	COG1215	transferase activity, transferring glycosyl groups
C4C67_RS16815	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4C67_RS16825	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4C67_RS16845	COG0318	PFAM AMP-dependent synthetase and ligase
C4C67_RS16850	COG2188	Transcriptional regulator
C4C67_RS16855	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C4C67_RS16860	COG2814	Major facilitator Superfamily
C4C67_RS16870	COG0259	pyridoxamine-phosphate oxidase activity
C4C67_RS16875	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4C67_RS16890	COG0583	DNA-binding transcription factor activity
C4C67_RS16915	COG0134	indole-3-glycerol-phosphate synthase activity
C4C67_RS16920	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4C67_RS16925	COG0512	Glutamine amidotransferase of anthranilate synthase
C4C67_RS16935	COG0546	phosphoglycolate phosphatase activity
C4C67_RS16940	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4C67_RS16945	COG2967	ApaG domain
C4C67_RS16950	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C4C67_RS16955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4C67_RS16960	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C4C67_RS16965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4C67_RS16975	COG0037	tRNA processing
C4C67_RS16985	COG3634	alkyl hydroperoxide reductase activity
C4C67_RS16990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4C67_RS16995	COG1024	Enoyl-CoA hydratase
C4C67_RS17020	COG0356	it plays a direct role in the translocation of protons across the membrane
C4C67_RS17030	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C4C67_RS17035	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4C67_RS17040	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C4C67_RS17045	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C4C67_RS17050	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C4C67_RS17055	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C4C67_RS17065	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C4C67_RS17070	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C4C67_RS17075	COG0210	DNA helicase
C4C67_RS17085	COG2195	Cleaves the N-terminal amino acid of tripeptides
C4C67_RS17095	COG4172	Belongs to the ABC transporter superfamily
C4C67_RS17100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4C67_RS17105	COG0601	transmembrane transport
C4C67_RS17125	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C4C67_RS17130	COG1024	Enoyl-CoA hydratase
C4C67_RS17135	COG1024	Enoyl-CoA hydratase
C4C67_RS17190	COG2132	Multicopper oxidase
C4C67_RS17200	COG1024	Enoyl-CoA hydratase
C4C67_RS17200	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4C67_RS17210	COG1414	Transcriptional regulator
C4C67_RS17220	COG0154	amidase activity
C4C67_RS17250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4C67_RS17255	COG3568	Endonuclease Exonuclease Phosphatase
C4C67_RS17260	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C4C67_RS17295	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C4C67_RS17305	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C4C67_RS17320	COG1137	ATPase activity
C4C67_RS17335	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C4C67_RS17340	COG2010	Cytochrome c
C4C67_RS17340	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4C67_RS17350	COG1660	Displays ATPase and GTPase activities
C4C67_RS17355	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4C67_RS17390	COG3181	Tripartite tricarboxylate transporter family receptor
C4C67_RS17400	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C4C67_RS17405	COG2890	protein-(glutamine-N5) methyltransferase activity
C4C67_RS17410	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C4C67_RS17415	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C4C67_RS17465	COG1960	acyl-CoA dehydrogenase activity
C4C67_RS17475	COG0183	Belongs to the thiolase family
C4C67_RS17480	COG1522	sequence-specific DNA binding
C4C67_RS17485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4C67_RS17505	COG1024	Enoyl-CoA hydratase
C4C67_RS17520	COG0604	alcohol dehydrogenase
C4C67_RS17540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4C67_RS17550	COG1960	acyl-CoA dehydrogenase activity
C4C67_RS17555	COG1960	acyl-CoA dehydrogenase activity
C4C67_RS17560	COG0277	FAD linked oxidase domain protein
C4C67_RS17570	COG3181	Tripartite tricarboxylate transporter family receptor
C4C67_RS17595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4C67_RS17605	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4C67_RS17610	COG3181	Tripartite tricarboxylate transporter family receptor
C4C67_RS17615	COG1960	acyl-CoA dehydrogenase activity
C4C67_RS17635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4C67_RS17640	COG1024	Enoyl-CoA hydratase
C4C67_RS17645	COG1960	acyl-CoA dehydrogenase activity
C4C67_RS17665	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C4C67_RS17670	COG0022	dehydrogenase e1 component
C4C67_RS17675	COG1024	Enoyl-CoA hydratase
C4C67_RS17680	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4C67_RS17700	COG0683	leucine binding
C4C67_RS17705	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4C67_RS17710	COG0411	ABC transporter
C4C67_RS17720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4C67_RS17735	COG3181	Tripartite tricarboxylate transporter family receptor
C4C67_RS17760	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C4C67_RS17765	COG0793	Belongs to the peptidase S41A family
C4C67_RS17770	COG4942	peptidase
C4C67_RS17775	COG0588	phosphoglycerate mutase activity
C4C67_RS17780	COG1054	Belongs to the UPF0176 family
C4C67_RS17785	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C4C67_RS17790	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C4C67_RS17795	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C4C67_RS17800	COG3181	Tripartite tricarboxylate transporter family receptor
C4C67_RS17815	COG2226	methyltransferase
C4C67_RS17820	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C4C67_RS17835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4C67_RS17840	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C4C67_RS17865	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C4C67_RS17890	COG1335	isochorismatase
C4C67_RS17895	COG2309	aminopeptidase activity
C4C67_RS17905	COG3473	Maleate cis-trans isomerase
C4C67_RS17915	COG2068	MobA-Related Protein
C4C67_RS17940	COG2204	response regulator
C4C67_RS17945	COG5000	phosphorelay sensor kinase activity
C4C67_RS17955	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4C67_RS17955	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C4C67_RS17965	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
C4C67_RS18000	COG0583	DNA-binding transcription factor activity
C4C67_RS18020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4C67_RS18025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4C67_RS18040	COG0758	DNA mediated transformation
C4C67_RS18045	COG1522	sequence-specific DNA binding
C4C67_RS18055	COG0242	peptide deformylase activity
C4C67_RS18070	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4C67_RS18080	COG0546	phosphoglycolate phosphatase activity
C4C67_RS18100	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4C67_RS18105	COG1942	4-Oxalocrotonate Tautomerase
C4C67_RS18110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4C67_RS18135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4C67_RS18155	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4C67_RS18160	COG1024	Enoyl-CoA hydratase
C4C67_RS18165	COG1414	Transcriptional regulator
C4C67_RS18170	COG0318	PFAM AMP-dependent synthetase and ligase
C4C67_RS18175	COG3181	Tripartite tricarboxylate transporter family receptor
C4C67_RS18220	COG3422	double-strand break repair
C4C67_RS18225	COG0330	HflC and HflK could
C4C67_RS18235	COG0251	oxidation-reduction process
C4C67_RS18285	COG3723	Recombinational DNA repair protein, rece pathway
C4C67_RS18320	COG0582	viral genome integration into host DNA
C4C67_RS18355	COG0706	membrane insertase activity
C4C67_RS18360	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C4C67_RS18365	COG0594	ribonuclease P activity
C4C67_RS18370	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C4C67_RS18375	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4C67_RS18390	COG1414	Transcriptional regulator
C4C67_RS18395	COG0154	amidase activity
C4C67_RS18410	COG1304	FMN binding
C4C67_RS18465	COG0183	Belongs to the thiolase family
C4C67_RS18470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4C67_RS18485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4C67_RS18490	COG3181	Tripartite tricarboxylate transporter family receptor
C4C67_RS18500	COG2358	TRAP transporter, solute receptor (TAXI family
C4C67_RS18510	COG1629	transport
C4C67_RS18515	COG2922	Belongs to the Smg family
C4C67_RS18540	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C4C67_RS18545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4C67_RS18550	COG1028	Short-chain dehydrogenase reductase Sdr
C4C67_RS18555	COG1012	belongs to the aldehyde dehydrogenase family
C4C67_RS18565	COG0028	Belongs to the TPP enzyme family
C4C67_RS18570	COG1522	sequence-specific DNA binding
C4C67_RS18575	COG3781	membrane
C4C67_RS18585	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4C67_RS18605	COG4206	TonB-dependent receptor
C4C67_RS18610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C4C67_RS18615	COG2022	thiamine diphosphate biosynthetic process
C4C67_RS18620	COG0351	phosphomethylpyrimidine kinase
C4C67_RS18625	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4C67_RS18640	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C4C67_RS18650	COG0628	permease
C4C67_RS18660	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4C67_RS18675	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C4C67_RS18680	COG0049	tRNA binding
C4C67_RS18685	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4C67_RS18690	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4C67_RS18695	COG0051	transcription antitermination factor activity, RNA binding
C4C67_RS18700	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C4C67_RS18705	COG0088	Forms part of the polypeptide exit tunnel
C4C67_RS18710	COG0089	rRNA binding
C4C67_RS18715	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C4C67_RS18720	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C4C67_RS18725	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C4C67_RS18730	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C4C67_RS18735	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C4C67_RS18740	COG0255	Belongs to the universal ribosomal protein uL29 family
C4C67_RS18745	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C4C67_RS18765	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C4C67_RS18770	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C4C67_RS18775	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C4C67_RS18780	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C4C67_RS18785	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C4C67_RS18790	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C4C67_RS18795	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C4C67_RS18800	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C4C67_RS18805	COG1841	ribosomal large subunit assembly
C4C67_RS18810	COG0200	Binds to the 23S rRNA
C4C67_RS18815	COG0201	protein transport
C4C67_RS18820	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C4C67_RS18825	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C4C67_RS18830	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C4C67_RS18835	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C4C67_RS18840	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C4C67_RS18845	COG0202	RNA polymerase activity
C4C67_RS18850	COG0203	ribosomal protein L17
C4C67_RS18855	COG0537	adenosine 5'-monophosphoramidase activity
C4C67_RS18860	COG1324	tolerance protein
C4C67_RS18865	COG4232	protein-disulfide reductase activity
C4C67_RS18880	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C4C67_RS18890	COG1333	cytochrome c biogenesis protein
C4C67_RS18895	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C4C67_RS18910	COG1965	Belongs to the frataxin family
C4C67_RS18920	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C4C67_RS18925	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C4C67_RS18930	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C4C67_RS18945	COG2814	Major facilitator Superfamily
C4C67_RS18950	COG0629	single-stranded DNA binding
C4C67_RS18990	COG0402	S-adenosylhomocysteine deaminase activity
C4C67_RS19000	COG0438	transferase activity, transferring glycosyl groups
C4C67_RS19020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4C67_RS19045	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C4C67_RS19070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4C67_RS19075	COG1956	GAF domain-containing protein
C4C67_RS19080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4C67_RS19095	COG1652	LysM domain
C4C67_RS19110	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C4C67_RS19125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4C67_RS19155	COG3181	Tripartite tricarboxylate transporter family receptor
C4C67_RS19170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4C67_RS19185	COG1024	Enoyl-CoA hydratase
C4C67_RS19200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4C67_RS19205	COG1309	transcriptional regulator
C4C67_RS19210	COG2816	NAD+ diphosphatase activity
C4C67_RS19215	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4C67_RS19300	COG2814	Major facilitator Superfamily
C4C67_RS19305	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4C67_RS19325	COG1999	signal sequence binding
C4C67_RS19330	COG0109	protoheme IX farnesyltransferase activity
C4C67_RS19370	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4C67_RS19390	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4C67_RS19395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4C67_RS19405	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C4C67_RS19410	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C4C67_RS19420	COG0069	glutamate synthase activity
C4C67_RS19420	COG0070	glutamate synthase
C4C67_RS19420	COG0067	glutamate synthase
C4C67_RS19430	COG3047	cAMP biosynthetic process
C4C67_RS19440	COG1127	ABC transporter
C4C67_RS19445	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4C67_RS19450	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C4C67_RS19455	COG2853	Lipoprotein
C4C67_RS19470	COG0842	Transport permease protein
C4C67_RS19480	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4C67_RS19485	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C4C67_RS19490	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C4C67_RS19495	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4C67_RS19500	COG0131	Imidazoleglycerol-phosphate dehydratase
C4C67_RS19505	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C4C67_RS19510	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C4C67_RS19515	COG0107	imidazoleglycerol-phosphate synthase activity
C4C67_RS19520	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C4C67_RS19525	COG0140	phosphoribosyl-ATP diphosphatase activity
C4C67_RS19530	COG0537	adenosine 5'-monophosphoramidase activity
C4C67_RS19535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4C67_RS19540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4C67_RS19555	COG3181	Tripartite tricarboxylate transporter family receptor
C4C67_RS19590	COG3702	type iv secretory pathway
C4C67_RS19595	COG3451	type IV secretory pathway VirB4
C4C67_RS19610	COG3736	Type IV secretory pathway, component VirB8
C4C67_RS19615	COG3504	Conjugal transfer protein
C4C67_RS19620	COG2948	multi-organism process
C4C67_RS19625	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
C4C67_RS19635	COG0697	spore germination
C4C67_RS19655	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4C67_RS19660	COG0747	negative chemotaxis
C4C67_RS19665	COG0601	transmembrane transport
C4C67_RS19670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4C67_RS19685	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C4C67_RS19695	COG0494	nUDIX hydrolase
C4C67_RS19740	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
C4C67_RS19745	COG0237	dephospho-CoA kinase activity
C4C67_RS19750	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C4C67_RS19765	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C4C67_RS19770	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C4C67_RS19780	COG0477	Major facilitator Superfamily
C4C67_RS19785	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4C67_RS19800	COG1126	abc transporter atp-binding protein
C4C67_RS19805	COG0765	amino acid transport
C4C67_RS19810	COG4597	amino acid ABC transporter
C4C67_RS19815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4C67_RS19820	COG2884	Cell division ATP-binding protein ftsE
C4C67_RS19825	COG2177	Part of the ABC transporter FtsEX involved in
C4C67_RS19830	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C4C67_RS19840	COG1194	a g-specific adenine glycosylase
C4C67_RS19850	COG2226	methyltransferase
C4C67_RS19860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4C67_RS19865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4C67_RS19880	COG1024	Enoyl-CoA hydratase
C4C67_RS19900	COG1024	Enoyl-CoA hydratase
C4C67_RS19905	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4C67_RS19920	COG0753	catalase activity
C4C67_RS19925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4C67_RS19930	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C4C67_RS19940	COG2175	clavaminate synthase activity
C4C67_RS19945	COG1473	amidohydrolase
C4C67_RS19950	COG4608	Belongs to the ABC transporter superfamily
C4C67_RS19955	COG0444	Belongs to the ABC transporter superfamily
C4C67_RS19970	COG0747	negative chemotaxis
C4C67_RS19975	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4C67_RS20010	COG0436	Aminotransferase
C4C67_RS20015	COG1278	Cold shock