locus-tag	class	description
A8B88_RS00005	COG1446	asparaginase
A8B88_RS00060	COG1530	ribonuclease E activity
A8B88_RS00065	COG0077	Prephenate dehydratase
A8B88_RS00080	COG1132	(ABC) transporter
A8B88_RS00090	COG4172	Belongs to the ABC transporter superfamily
A8B88_RS00095	COG0747	negative chemotaxis
A8B88_RS00130	COG0504	CTP synthase activity
A8B88_RS00135	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A8B88_RS00145	COG0148	phosphopyruvate hydratase activity
A8B88_RS00150	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A8B88_RS00180	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A8B88_RS00190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A8B88_RS00215	COG1981	membrane
A8B88_RS00245	COG0039	L-malate dehydrogenase activity
A8B88_RS00250	COG2188	Transcriptional regulator
A8B88_RS00255	COG2009	succinate dehydrogenase
A8B88_RS00260	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A8B88_RS00265	COG1053	succinate dehydrogenase
A8B88_RS00270	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A8B88_RS00275	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A8B88_RS00280	COG0372	Belongs to the citrate synthase family
A8B88_RS00300	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8B88_RS00300	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A8B88_RS00310	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8B88_RS00315	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A8B88_RS00330	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A8B88_RS00335	COG3842	ATPase activity
A8B88_RS00340	COG1176	ABC-type spermidine putrescine transport system, permease component I
A8B88_RS00345	COG1177	transmembrane transport
A8B88_RS00370	COG1960	acyl-CoA dehydrogenase activity
A8B88_RS00375	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A8B88_RS00380	COG0704	Plays a role in the regulation of phosphate uptake
A8B88_RS00390	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
A8B88_RS00395	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A8B88_RS00395	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A8B88_RS00400	COG1643	Atp-dependent helicase
A8B88_RS00415	COG0438	transferase activity, transferring glycosyl groups
A8B88_RS00420	COG0726	polysaccharide deacetylase
A8B88_RS00425	COG0463	Glycosyl transferase, family 2
A8B88_RS00430	COG0438	transferase activity, transferring glycosyl groups
A8B88_RS00435	COG2194	sulfuric ester hydrolase activity
A8B88_RS00460	COG0859	PFAM glycosyl transferase family 9
A8B88_RS00465	COG1132	(ABC) transporter
A8B88_RS00480	COG0077	Prephenate dehydratase
A8B88_RS00535	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8B88_RS00540	COG0154	amidase activity
A8B88_RS00550	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A8B88_RS00565	COG0495	leucyl-tRNA aminoacylation
A8B88_RS00570	COG2814	Major facilitator Superfamily
A8B88_RS00600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A8B88_RS00605	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A8B88_RS00610	COG2814	Major facilitator Superfamily
A8B88_RS00615	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A8B88_RS00630	COG4176	ABC-type proline glycine betaine transport system permease component
A8B88_RS00640	COG1942	4-Oxalocrotonate Tautomerase
A8B88_RS00645	COG0183	Belongs to the thiolase family
A8B88_RS00655	COG1802	Transcriptional regulator
A8B88_RS00665	COG1024	Enoyl-CoA hydratase
A8B88_RS00680	COG2032	superoxide dismutase activity
A8B88_RS00695	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A8B88_RS00720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8B88_RS00725	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A8B88_RS00735	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A8B88_RS00740	COG0736	holo-[acyl-carrier-protein] synthase activity
A8B88_RS00745	COG1472	Belongs to the glycosyl hydrolase 3 family
A8B88_RS00750	COG0322	excinuclease ABC activity
A8B88_RS00755	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A8B88_RS00770	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A8B88_RS00770	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A8B88_RS00775	COG2224	Isocitrate lyase
A8B88_RS00795	COG0559	Belongs to the binding-protein-dependent transport system permease family
A8B88_RS00805	COG4638	Rieske (2fe-2S)
A8B88_RS00815	COG1024	Enoyl-CoA hydratase
A8B88_RS00825	COG0633	Ferredoxin
A8B88_RS00830	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B88_RS00845	COG0183	Belongs to the thiolase family
A8B88_RS00855	COG4692	amylo-alpha-1,6-glucosidase activity
A8B88_RS00860	COG0583	DNA-binding transcription factor activity
A8B88_RS00885	COG2346	COG2346, Truncated hemoglobins
A8B88_RS01015	COG2207	Transcriptional regulator
A8B88_RS01060	COG1132	(ABC) transporter
A8B88_RS01085	COG0659	secondary active sulfate transmembrane transporter activity
A8B88_RS01115	COG2169	Transcriptional regulator
A8B88_RS01120	COG5507	3-demethylubiquinone-9 3-methyltransferase
A8B88_RS01125	COG0384	phenazine biosynthesis protein PhzF
A8B88_RS01130	COG0583	DNA-binding transcription factor activity
A8B88_RS01135	COG2733	membrane
A8B88_RS01150	COG1012	belongs to the aldehyde dehydrogenase family
A8B88_RS01155	COG3284	Transcriptional regulator
A8B88_RS01175	COG1346	cytolysis
A8B88_RS01180	COG1380	Effector of murein hydrolase LrgA
A8B88_RS01185	COG4106	trans-aconitate 2-methyltransferase activity
A8B88_RS01185	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A8B88_RS01195	COG0156	8-amino-7-oxononanoate synthase activity
A8B88_RS01265	COG1131	(ABC) transporter
A8B88_RS01270	COG0842	Transport permease protein
A8B88_RS01275	COG0628	permease
A8B88_RS01305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A8B88_RS01315	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A8B88_RS01320	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A8B88_RS01325	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A8B88_RS01330	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A8B88_RS01335	COG0330	HflC and HflK could
A8B88_RS01340	COG0330	HflC and HflK could
A8B88_RS01345	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A8B88_RS01350	COG1923	regulation of RNA biosynthetic process
A8B88_RS01355	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A8B88_RS01360	COG1160	GTP binding
A8B88_RS01365	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A8B88_RS01370	COG2976	Protein conserved in bacteria
A8B88_RS01375	COG0124	histidyl-tRNA synthetase
A8B88_RS01380	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A8B88_RS01390	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A8B88_RS01395	COG0105	UTP biosynthetic process
A8B88_RS01400	COG0525	valine-tRNA ligase activity
A8B88_RS01415	COG0642	Histidine kinase
A8B88_RS01435	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A8B88_RS01440	COG0336	Belongs to the RNA methyltransferase TrmD family
A8B88_RS01445	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A8B88_RS01450	COG0228	four-way junction DNA binding
A8B88_RS01460	COG0425	Belongs to the sulfur carrier protein TusA family
A8B88_RS01465	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A8B88_RS01510	COG0154	amidase activity
A8B88_RS01515	COG4172	Belongs to the ABC transporter superfamily
A8B88_RS01520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8B88_RS01525	COG0601	transmembrane transport
A8B88_RS01555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8B88_RS01565	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A8B88_RS01580	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A8B88_RS01600	COG1024	Enoyl-CoA hydratase
A8B88_RS01620	COG0633	Ferredoxin
A8B88_RS01625	COG0443	Heat shock 70 kDa protein
A8B88_RS01630	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A8B88_RS01635	COG0316	Belongs to the HesB IscA family
A8B88_RS01640	COG0822	iron-sulfur transferase activity
A8B88_RS01645	COG1104	cysteine desulfurase activity
A8B88_RS01655	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A8B88_RS01660	COG0556	nucleotide-excision repair
A8B88_RS01670	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A8B88_RS01675	COG3468	outer membrane autotransporter barrel domain protein
A8B88_RS01700	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A8B88_RS01715	COG1960	acyl-CoA dehydrogenase activity
A8B88_RS01720	COG1028	Short-chain dehydrogenase reductase Sdr
A8B88_RS01725	COG0183	Belongs to the thiolase family
A8B88_RS01735	COG1024	Enoyl-CoA hydratase
A8B88_RS01750	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B88_RS01755	COG0583	DNA-binding transcription factor activity
A8B88_RS01760	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A8B88_RS01765	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A8B88_RS01770	COG0740	serine-type endopeptidase activity
A8B88_RS01775	COG0544	peptidyl-prolyl cis-trans isomerase activity
A8B88_RS01785	COG1278	Cold shock
A8B88_RS01795	COG1278	Cold shock
A8B88_RS01830	COG2171	N-acyltransferase activity
A8B88_RS01835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8B88_RS01840	COG2890	protein-(glutamine-N5) methyltransferase activity
A8B88_RS01845	COG0488	(ABC) transporter
A8B88_RS01850	COG4771	TonB-dependent receptor
A8B88_RS01855	COG0210	DNA helicase
A8B88_RS01875	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A8B88_RS01875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A8B88_RS01880	COG0196	riboflavin kinase activity
A8B88_RS01885	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A8B88_RS01890	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A8B88_RS01895	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A8B88_RS01905	COG1522	sequence-specific DNA binding
A8B88_RS01925	COG2833	Protein of unknown function (DUF455)
A8B88_RS01945	COG0189	ligase activity
A8B88_RS01945	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A8B88_RS01950	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A8B88_RS01950	COG1181	Belongs to the D-alanine--D-alanine ligase family
A8B88_RS01955	COG3237	CsbD-like
A8B88_RS01965	COG2823	Periplasmic or secreted lipoprotein
A8B88_RS01980	COG4181	ATPase activity
A8B88_RS01990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A8B88_RS01995	COG0584	glycerophosphoryl diester phosphodiesterase
A8B88_RS02000	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A8B88_RS02010	COG0678	peroxiredoxin activity
A8B88_RS02010	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A8B88_RS02020	COG0789	Transcriptional regulator
A8B88_RS02025	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A8B88_RS02055	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A8B88_RS02060	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A8B88_RS02070	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A8B88_RS02075	COG2252	PERMEase
A8B88_RS02085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8B88_RS02115	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A8B88_RS02120	COG2358	TRAP transporter, solute receptor (TAXI family
A8B88_RS02150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A8B88_RS02155	COG1366	Belongs to the anti-sigma-factor antagonist family
A8B88_RS02160	COG2172	sigma factor antagonist activity
A8B88_RS02165	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A8B88_RS02175	COG2770	Histidine kinase
A8B88_RS02175	COG2208	phosphoserine phosphatase activity
A8B88_RS02200	COG1595	DNA-templated transcription, initiation
A8B88_RS02215	COG4792	protein secretion
A8B88_RS02220	COG4791	protein targeting
A8B88_RS02225	COG4794	Type iii secretion
A8B88_RS02230	COG4790	Type iii secretion
A8B88_RS02265	COG4669	(LipO)protein
A8B88_RS02330	COG4789	Type iii secretion
A8B88_RS02360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A8B88_RS02365	COG0840	transmembrane signaling receptor activity
A8B88_RS02370	COG2233	PERMEase
A8B88_RS02390	COG0492	ferredoxin-NADP+ reductase activity
A8B88_RS02395	COG1840	ABC-type Fe3 transport system, periplasmic component
A8B88_RS02400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A8B88_RS02405	COG1178	ABC-type Fe3 transport system permease component
A8B88_RS02410	COG3842	ATPase activity
A8B88_RS02415	COG0583	DNA-binding transcription factor activity
A8B88_RS02435	COG0501	Belongs to the peptidase M48B family
A8B88_RS02445	COG0697	spore germination
A8B88_RS02455	COG1846	Transcriptional regulator
A8B88_RS02465	COG1566	PFAM secretion protein HlyD family protein
A8B88_RS02470	COG2814	Major facilitator Superfamily
A8B88_RS02475	COG0473	3-isopropylmalate dehydrogenase activity
A8B88_RS02485	COG0747	negative chemotaxis
A8B88_RS02495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8B88_RS02510	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A8B88_RS02535	COG1012	belongs to the aldehyde dehydrogenase family
A8B88_RS02545	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A8B88_RS02550	COG1115	amino acid carrier protein
A8B88_RS02555	COG0433	COG0433 Predicted ATPase
A8B88_RS02560	COG0217	transcriptional regulatory protein
A8B88_RS02565	COG0151	Belongs to the GarS family
A8B88_RS02570	COG0408	coproporphyrinogen oxidase activity
A8B88_RS02575	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A8B88_RS02580	COG0799	negative regulation of ribosome biogenesis
A8B88_RS02585	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A8B88_RS02590	COG0424	maF-like protein
A8B88_RS02595	COG3468	outer membrane autotransporter barrel domain protein
A8B88_RS02645	COG0583	DNA-binding transcription factor activity
A8B88_RS02660	COG0730	response to heat
A8B88_RS02665	COG0697	spore germination
A8B88_RS02700	COG2885	chlorophyll binding
A8B88_RS02725	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A8B88_RS02730	COG3384	dioxygenase
A8B88_RS02745	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A8B88_RS02750	COG3474	cytochrome
A8B88_RS02760	COG1595	DNA-templated transcription, initiation
A8B88_RS02775	COG2204	response regulator
A8B88_RS02815	COG4964	Belongs to the GSP D family
A8B88_RS02865	COG1846	Transcriptional regulator
A8B88_RS02870	COG4172	Belongs to the ABC transporter superfamily
A8B88_RS02875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8B88_RS02880	COG0601	transmembrane transport
A8B88_RS02885	COG0747	negative chemotaxis
A8B88_RS02895	COG0598	Magnesium transport protein CorA
A8B88_RS02900	COG0210	DNA helicase
A8B88_RS02915	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A8B88_RS02920	COG1012	belongs to the aldehyde dehydrogenase family
A8B88_RS02925	COG0483	inositol monophosphate 1-phosphatase activity
A8B88_RS02930	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A8B88_RS02940	COG1045	serine acetyltransferase
A8B88_RS02945	COG0166	Belongs to the GPI family
A8B88_RS02965	COG1846	Transcriptional regulator
A8B88_RS02985	COG0726	polysaccharide deacetylase
A8B88_RS02985	COG1649	PFAM Uncharacterised BCR, COG1649
A8B88_RS02990	COG1215	transferase activity, transferring glycosyl groups
A8B88_RS03000	COG1902	pentaerythritol trinitrate reductase activity
A8B88_RS03025	COG0251	oxidation-reduction process
A8B88_RS03040	COG1414	Transcriptional regulator
A8B88_RS03045	COG1902	pentaerythritol trinitrate reductase activity
A8B88_RS03045	COG0446	pyridine nucleotide-disulphide oxidoreductase
A8B88_RS03055	COG3842	ATPase activity
A8B88_RS03085	COG0583	DNA-binding transcription factor activity
A8B88_RS03095	COG1028	Short-chain dehydrogenase reductase Sdr
A8B88_RS03100	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
A8B88_RS03105	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A8B88_RS03120	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8B88_RS03120	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A8B88_RS03125	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8B88_RS03150	COG0527	aspartate kinase activity
A8B88_RS03155	COG0037	tRNA processing
A8B88_RS03165	COG0825	malonyl-CoA metabolic process
A8B88_RS03175	COG0215	cysteine-tRNA ligase activity
A8B88_RS03190	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A8B88_RS03195	COG1968	undecaprenyl-diphosphatase activity
A8B88_RS03200	COG1253	flavin adenine dinucleotide binding
A8B88_RS03205	COG0483	inositol monophosphate 1-phosphatase activity
A8B88_RS03225	COG0668	transmembrane transport
A8B88_RS03250	COG0583	DNA-binding transcription factor activity
A8B88_RS03275	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8B88_RS03290	COG2831	hemolysin activation secretion protein
A8B88_RS03295	COG3539	Fimbrial protein
A8B88_RS03300	COG3188	usher protein
A8B88_RS03305	COG3121	Chaperone
A8B88_RS03315	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
A8B88_RS03315	COG3210	domain, Protein
A8B88_RS03315	COG3064	Membrane
A8B88_RS03320	COG2197	response regulator
A8B88_RS03325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8B88_RS03325	COG2205	protein histidine kinase activity
A8B88_RS03335	COG4336	lyase activity
A8B88_RS03360	COG3189	MarR family transcriptional regulator
A8B88_RS03375	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8B88_RS03385	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8B88_RS03385	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A8B88_RS03395	COG0028	Belongs to the TPP enzyme family
A8B88_RS03405	COG1012	belongs to the aldehyde dehydrogenase family
A8B88_RS03410	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A8B88_RS03415	COG0010	Belongs to the arginase family
A8B88_RS03420	COG1126	abc transporter atp-binding protein
A8B88_RS03430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8B88_RS03445	COG0084	hydrolase, TatD family'
A8B88_RS03450	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A8B88_RS03455	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A8B88_RS03460	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A8B88_RS03480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8B88_RS03485	COG1959	2 iron, 2 sulfur cluster binding
A8B88_RS03490	COG1017	nitric oxide dioxygenase activity
A8B88_RS03490	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A8B88_RS03525	COG0488	(ABC) transporter
A8B88_RS03530	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A8B88_RS03545	COG1024	Enoyl-CoA hydratase
A8B88_RS03550	COG1619	proteins homologs of microcin C7 resistance protein MccF
A8B88_RS03555	COG0590	tRNA wobble adenosine to inosine editing
A8B88_RS03580	COG2212	antiporter activity
A8B88_RS03585	COG1863	multisubunit Na H antiporter MnhE subunit
A8B88_RS03590	COG0651	ATP synthesis coupled electron transport
A8B88_RS03595	COG1006	Multisubunit Na H antiporter MnhC subunit
A8B88_RS03600	COG2111	Na H antiporter
A8B88_RS03600	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A8B88_RS03605	COG3181	Tripartite tricarboxylate transporter family receptor
A8B88_RS03620	COG0583	DNA-binding transcription factor activity
A8B88_RS03625	COG1028	Short-chain dehydrogenase reductase Sdr
A8B88_RS03655	COG0431	NADPH-dependent FMN reductase
A8B88_RS03700	COG1028	Short-chain dehydrogenase reductase Sdr
A8B88_RS03705	COG0179	Fumarylacetoacetate (FAA) hydrolase
A8B88_RS03735	COG0625	glutathione transferase activity
A8B88_RS03740	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
A8B88_RS03745	COG2944	sequence-specific DNA binding
A8B88_RS03755	COG2197	response regulator
A8B88_RS03780	COG3119	arylsulfatase activity
A8B88_RS03810	COG0714	Associated with various cellular activities
A8B88_RS03830	COG1028	Short-chain dehydrogenase reductase Sdr
A8B88_RS03835	COG0861	Integral membrane protein TerC family
A8B88_RS03880	COG0300	oxidoreductase activity
A8B88_RS03905	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A8B88_RS03920	COG0438	transferase activity, transferring glycosyl groups
A8B88_RS03955	COG0783	Belongs to the Dps family
A8B88_RS03970	COG0583	DNA-binding transcription factor activity
A8B88_RS03975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A8B88_RS03990	COG0656	L-ascorbic acid biosynthetic process
A8B88_RS04000	COG0583	DNA-binding transcription factor activity
A8B88_RS04010	COG1840	ABC-type Fe3 transport system, periplasmic component
A8B88_RS04015	COG1178	ABC-type Fe3 transport system permease component
A8B88_RS04020	COG3842	ATPase activity
A8B88_RS04030	COG1741	Belongs to the pirin family
A8B88_RS04035	COG1741	Belongs to the pirin family
A8B88_RS04040	COG0583	DNA-binding transcription factor activity
A8B88_RS04045	COG2204	response regulator
A8B88_RS04055	COG0174	glutamine synthetase
A8B88_RS04060	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A8B88_RS04070	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A8B88_RS04075	COG2200	EAL domain
A8B88_RS04075	COG2199	diguanylate cyclase activity
A8B88_RS04100	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A8B88_RS04105	COG1561	YicC-like family, N-terminal region
A8B88_RS04125	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A8B88_RS04130	COG0791	NLP P60 protein
A8B88_RS04135	COG1028	Short-chain dehydrogenase reductase Sdr
A8B88_RS04140	COG2863	cytochrome
A8B88_RS04145	COG3258	Cytochrome c
A8B88_RS04150	COG0194	GDP metabolic process
A8B88_RS04155	COG1758	RNA polymerase activity
A8B88_RS04160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A8B88_RS04165	COG1126	abc transporter atp-binding protein
A8B88_RS04170	COG0765	amino acid transport
A8B88_RS04175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8B88_RS04185	COG1994	Peptidase M50
A8B88_RS04190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8B88_RS04195	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
A8B88_RS04200	COG3539	Fimbrial protein
A8B88_RS04205	COG2850	peptidyl-arginine hydroxylation
A8B88_RS04210	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A8B88_RS04215	COG3360	Dodecin
A8B88_RS04255	COG0009	L-threonylcarbamoyladenylate synthase
A8B88_RS04260	COG2321	neutral zinc metallopeptidase
A8B88_RS04280	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A8B88_RS04285	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A8B88_RS04290	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A8B88_RS04300	COG1074	ATP-dependent DNA helicase activity
A8B88_RS04310	COG2814	Major facilitator Superfamily
A8B88_RS04320	COG1686	Belongs to the peptidase S11 family
A8B88_RS04335	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A8B88_RS04340	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A8B88_RS04345	COG4974	Belongs to the 'phage' integrase family
A8B88_RS04350	COG0583	DNA-binding transcription factor activity
A8B88_RS04355	COG0028	Belongs to the TPP enzyme family
A8B88_RS04370	COG0028	Belongs to the TPP enzyme family
A8B88_RS04375	COG1126	abc transporter atp-binding protein
A8B88_RS04380	COG0765	amino acid transport
A8B88_RS04395	COG1414	Transcriptional regulator
A8B88_RS04400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8B88_RS04405	COG0009	L-threonylcarbamoyladenylate synthase
A8B88_RS04410	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A8B88_RS04415	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A8B88_RS04420	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A8B88_RS04425	COG2944	sequence-specific DNA binding
A8B88_RS04435	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A8B88_RS04490	COG1126	abc transporter atp-binding protein
A8B88_RS04495	COG0765	amino acid transport
A8B88_RS04500	COG0765	amino acid transport
A8B88_RS04505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8B88_RS04515	COG2423	ornithine cyclodeaminase activity
A8B88_RS04525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A8B88_RS04530	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8B88_RS04540	COG0189	ligase activity
A8B88_RS04545	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A8B88_RS04550	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A8B88_RS04555	COG2197	response regulator
A8B88_RS04565	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A8B88_RS04585	COG1289	transmembrane transporter activity
A8B88_RS04595	COG3022	response to hydroperoxide
A8B88_RS04610	COG0135	phosphoribosylanthranilate isomerase activity
A8B88_RS04630	COG0101	tRNA pseudouridine synthase activity
A8B88_RS04640	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A8B88_RS04645	COG0473	3-isopropylmalate dehydrogenase activity
A8B88_RS04650	COG0066	3-isopropylmalate dehydratase activity
A8B88_RS04655	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A8B88_RS04665	COG1122	ATPase activity
A8B88_RS04695	COG0437	4 iron, 4 sulfur cluster binding
A8B88_RS04700	COG3383	formate dehydrogenase (NAD+) activity
A8B88_RS04700	COG0243	molybdopterin cofactor binding
A8B88_RS04730	COG0489	protein tyrosine kinase activity
A8B88_RS04735	COG0746	molybdenum cofactor guanylyltransferase activity
A8B88_RS04740	COG0303	'Molybdopterin
A8B88_RS04745	COG1763	Mo-molybdopterin cofactor biosynthetic process
A8B88_RS04755	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A8B88_RS04760	COG5001	Diguanylate cyclase
A8B88_RS04780	COG3842	ATPase activity
A8B88_RS04790	COG0406	alpha-ribazole phosphatase activity
A8B88_RS04800	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A8B88_RS04805	COG0505	Belongs to the CarA family
A8B88_RS04810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A8B88_RS04840	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A8B88_RS04845	COG1960	acyl-CoA dehydrogenase activity
A8B88_RS04855	COG2867	negative regulation of translational initiation
A8B88_RS04865	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A8B88_RS04870	COG3706	GGDEF domain
A8B88_RS04875	COG0330	HflC and HflK could
A8B88_RS04890	COG0519	Catalyzes the synthesis of GMP from XMP
A8B88_RS04890	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A8B88_RS04900	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A8B88_RS04905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A8B88_RS04910	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A8B88_RS04915	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A8B88_RS04925	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A8B88_RS04930	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A8B88_RS04935	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
A8B88_RS04940	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A8B88_RS04945	COG0750	zinc metalloprotease
A8B88_RS04950	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A8B88_RS04960	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A8B88_RS04965	COG0233	cytoplasmic translational termination
A8B88_RS04970	COG0528	UMP kinase activity
A8B88_RS04975	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A8B88_RS04980	COG0052	Belongs to the universal ribosomal protein uS2 family
A8B88_RS04985	COG0024	Methionine aminopeptidase
A8B88_RS04990	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A8B88_RS05020	COG0285	dihydrofolate synthase activity
A8B88_RS05055	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A8B88_RS05065	COG1677	Flagellar hook-basal body complex protein FliE
A8B88_RS05075	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A8B88_RS05085	COG1157	protein secretion by the type III secretion system
A8B88_RS05110	COG1580	Controls the rotational direction of flagella during chemotaxis
A8B88_RS05130	COG1338	Plays a role in the flagellum-specific transport system
A8B88_RS05150	COG0840	transmembrane signaling receptor activity
A8B88_RS05155	COG0840	transmembrane signaling receptor activity
A8B88_RS05160	COG0840	transmembrane signaling receptor activity
A8B88_RS05170	COG1256	bacterial-type flagellum assembly
A8B88_RS05180	COG1706	bacterial-type flagellum-dependent cell motility
A8B88_RS05185	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A8B88_RS05200	COG1749	Flagellar hook protein flgE
A8B88_RS05210	COG1558	bacterial-type flagellum-dependent cell motility
A8B88_RS05215	COG1815	bacterial-type flagellum-dependent cell motility
A8B88_RS05255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8B88_RS05260	COG0765	amino acid transport
A8B88_RS05265	COG1126	abc transporter atp-binding protein
A8B88_RS05280	COG4948	Mandelate Racemase Muconate Lactonizing
A8B88_RS05285	COG3181	Tripartite tricarboxylate transporter family receptor
A8B88_RS05295	COG0066	3-isopropylmalate dehydratase activity
A8B88_RS05310	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B88_RS05320	COG3181	Tripartite tricarboxylate transporter family receptor
A8B88_RS05330	COG1802	Transcriptional regulator
A8B88_RS05345	COG0583	DNA-binding transcription factor activity
A8B88_RS05365	COG1695	Transcriptional regulator
A8B88_RS05370	COG3568	Endonuclease Exonuclease Phosphatase
A8B88_RS05375	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A8B88_RS05390	COG0392	lysyltransferase activity
A8B88_RS05430	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A8B88_RS05440	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A8B88_RS05450	COG1640	4-alpha-glucanotransferase
A8B88_RS05465	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A8B88_RS05495	COG0667	Aldo Keto reductase
A8B88_RS05510	COG2259	Doxx family
A8B88_RS05540	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B88_RS05560	COG0386	Belongs to the glutathione peroxidase family
A8B88_RS05565	COG0625	glutathione transferase activity
A8B88_RS05580	COG0095	Lipoate-protein ligase
A8B88_RS05595	COG0688	phosphatidylethanolamine metabolic process
A8B88_RS05605	COG1464	Belongs to the NlpA lipoprotein family
A8B88_RS05620	COG2363	Small membrane protein
A8B88_RS05645	COG3842	ATPase activity
A8B88_RS05650	COG0395	ABC-type sugar transport system, permease component
A8B88_RS05655	COG1175	transmembrane transport
A8B88_RS05660	COG1653	transport
A8B88_RS05670	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A8B88_RS05685	COG0559	Belongs to the binding-protein-dependent transport system permease family
A8B88_RS05705	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A8B88_RS05720	COG0697	spore germination
A8B88_RS05730	COG2311	Membrane
A8B88_RS05755	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A8B88_RS05765	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A8B88_RS05770	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A8B88_RS05775	COG1760	l-serine dehydratase
A8B88_RS05780	COG1283	sodium-dependent phosphate transmembrane transporter activity
A8B88_RS05785	COG0412	Dienelactone hydrolase
A8B88_RS05800	COG1611	Belongs to the LOG family
A8B88_RS05820	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A8B88_RS05825	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A8B88_RS05830	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A8B88_RS05835	COG0195	Participates in both transcription termination and antitermination
A8B88_RS05835	COG2251	uridine kinase activity
A8B88_RS05840	COG0779	Required for maturation of 30S ribosomal subunits
A8B88_RS05845	COG1187	pseudouridine synthase activity
A8B88_RS05850	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A8B88_RS05860	COG0583	DNA-binding transcription factor activity
A8B88_RS05870	COG0523	cobalamin synthesis protein
A8B88_RS05890	COG0625	glutathione transferase activity
A8B88_RS05895	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A8B88_RS05900	COG1047	Peptidyl-prolyl cis-trans
A8B88_RS05905	COG2003	Belongs to the UPF0758 family
A8B88_RS05910	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A8B88_RS05915	COG3483	tryptophan 2,3-dioxygenase activity
A8B88_RS05920	COG0254	rRNA binding
A8B88_RS05930	COG0534	Mate efflux family protein
A8B88_RS05970	COG1028	Short-chain dehydrogenase reductase Sdr
A8B88_RS05975	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A8B88_RS05980	COG1562	ergosterol biosynthetic process
A8B88_RS05985	COG1562	ergosterol biosynthetic process
A8B88_RS05990	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
A8B88_RS05990	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
A8B88_RS05995	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A8B88_RS06005	COG0842	Transport permease protein
A8B88_RS06010	COG1131	(ABC) transporter
A8B88_RS06030	COG1477	protein flavinylation
A8B88_RS06045	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
A8B88_RS06060	COG5564	TIM-barrel signal transduction protein
A8B88_RS06065	COG5441	Belongs to the UPF0261 family
A8B88_RS06075	COG3468	outer membrane autotransporter barrel domain protein
A8B88_RS06080	COG3468	outer membrane autotransporter barrel domain protein
A8B88_RS06090	COG0542	response to heat
A8B88_RS06095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A8B88_RS06110	COG0494	nUDIX hydrolase
A8B88_RS06115	COG3530	Putative quorum-sensing-regulated virulence factor
A8B88_RS06125	COG1595	DNA-templated transcription, initiation
A8B88_RS06130	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A8B88_RS06165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8B88_RS06170	COG0765	amino acid transport
A8B88_RS06175	COG0765	amino acid transport
A8B88_RS06205	COG2988	succinylglutamate desuccinylase activity
A8B88_RS06230	COG3181	Tripartite tricarboxylate transporter family receptor
A8B88_RS06235	COG2084	Dehydrogenase
A8B88_RS06250	COG1619	proteins homologs of microcin C7 resistance protein MccF
A8B88_RS06265	COG2814	Major facilitator Superfamily
A8B88_RS06275	COG0583	DNA-binding transcription factor activity
A8B88_RS06315	COG0672	)-iron permease
A8B88_RS06330	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
A8B88_RS06335	COG1028	Short-chain dehydrogenase reductase Sdr
A8B88_RS06340	COG3243	poly(R)-hydroxyalkanoic acid synthase
A8B88_RS06350	COG0564	pseudouridine synthase activity
A8B88_RS06360	COG1199	ATP-dependent helicase activity
A8B88_RS06365	COG2183	response to ionizing radiation
A8B88_RS06370	COG0180	Tryptophanyl-tRNA synthetase
A8B88_RS06390	COG3181	Tripartite tricarboxylate transporter family receptor
A8B88_RS06400	COG0583	DNA-binding transcription factor activity
A8B88_RS06405	COG1028	Short-chain dehydrogenase reductase Sdr
A8B88_RS06410	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A8B88_RS06415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A8B88_RS06420	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8B88_RS06425	COG0567	Dehydrogenase, E1 component
A8B88_RS06430	COG1297	OPT oligopeptide transporter protein
A8B88_RS06435	COG1297	OPT oligopeptide transporter protein
A8B88_RS06440	COG1522	sequence-specific DNA binding
A8B88_RS06450	COG0280	phosphate acetyltransferase
A8B88_RS06450	COG0281	malic enzyme
A8B88_RS06455	COG3539	Fimbrial protein
A8B88_RS06470	COG0613	PHP domain protein
A8B88_RS06505	COG0084	hydrolase, TatD family'
A8B88_RS06510	COG1136	(ABC) transporter
A8B88_RS06525	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A8B88_RS06530	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A8B88_RS06535	COG1028	Short-chain dehydrogenase reductase Sdr
A8B88_RS06540	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A8B88_RS06555	COG1022	Amp-dependent synthetase and ligase
A8B88_RS06590	COG2205	protein histidine kinase activity
A8B88_RS06595	COG0745	RESPONSE REGULATOR receiver
A8B88_RS06600	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A8B88_RS06610	COG1295	ribonuclease BN
A8B88_RS06625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A8B88_RS06650	COG1534	Rna-binding protein
A8B88_RS06655	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A8B88_RS06660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A8B88_RS06670	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A8B88_RS06680	COG0248	Ppx GppA phosphatase
A8B88_RS06705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A8B88_RS06720	COG2732	(Barnase) inhibitor
A8B88_RS06730	COG0280	phosphate acetyltransferase
A8B88_RS06730	COG0281	malic enzyme
A8B88_RS06740	COG0436	Aminotransferase
A8B88_RS06745	COG0741	lytic transglycosylase activity
A8B88_RS06750	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A8B88_RS06775	COG1648	precorrin-2 dehydrogenase activity
A8B88_RS06775	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A8B88_RS06780	COG3468	outer membrane autotransporter barrel domain protein
A8B88_RS06790	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A8B88_RS06795	COG2027	D-alanyl-D-alanine carboxypeptidase
A8B88_RS06800	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A8B88_RS06810	COG1862	Preprotein translocase
A8B88_RS06815	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A8B88_RS06820	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A8B88_RS06835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A8B88_RS06840	COG1702	phosphate starvation-inducible protein PhoH
A8B88_RS06845	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A8B88_RS06850	COG4535	Mg2 and Co2 transporter CorC
A8B88_RS06860	COG0667	Aldo Keto reductase
A8B88_RS06885	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
A8B88_RS06890	COG0745	RESPONSE REGULATOR receiver
A8B88_RS06895	COG2201	protein-glutamate methylesterase activity
A8B88_RS06905	COG0840	transmembrane signaling receptor activity
A8B88_RS06920	COG0745	RESPONSE REGULATOR receiver
A8B88_RS06955	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A8B88_RS06965	COG0739	heme binding
A8B88_RS06975	COG0521	Mo-molybdopterin cofactor biosynthetic process
A8B88_RS06985	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A8B88_RS07015	COG0625	glutathione transferase activity
A8B88_RS07030	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A8B88_RS07035	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A8B88_RS07040	COG0126	phosphoglycerate kinase activity
A8B88_RS07045	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A8B88_RS07050	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A8B88_RS07055	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A8B88_RS07065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A8B88_RS07070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A8B88_RS07075	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8B88_RS07080	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A8B88_RS07090	COG4566	intracellular signal transduction
A8B88_RS07095	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A8B88_RS07100	COG0339	signal peptide processing
A8B88_RS07105	COG1999	signal sequence binding
A8B88_RS07125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8B88_RS07135	COG1187	pseudouridine synthase activity
A8B88_RS07140	COG3161	chorismate lyase activity
A8B88_RS07145	COG2814	Major facilitator Superfamily
A8B88_RS07155	COG0667	Aldo Keto reductase
A8B88_RS07170	COG0335	large ribosomal subunit rRNA binding
A8B88_RS07200	COG0175	sulfate reduction
A8B88_RS07205	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A8B88_RS07210	COG4208	sulfate ABC transporter
A8B88_RS07215	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A8B88_RS07230	COG0450	alkyl hydroperoxide reductase
A8B88_RS07235	COG1960	acyl-CoA dehydrogenase activity
A8B88_RS07250	COG0123	including yeast histone deacetylase and acetoin utilization protein
A8B88_RS07255	COG2951	lytic endotransglycosylase activity
A8B88_RS07270	COG1555	photosystem II stabilization
A8B88_RS07270	COG1596	polysaccharide export
A8B88_RS07275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8B88_RS07280	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A8B88_RS07285	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A8B88_RS07305	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A8B88_RS07310	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A8B88_RS07315	COG0287	Prephenate dehydrogenase
A8B88_RS07325	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A8B88_RS07340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A8B88_RS07350	COG2814	Major facilitator Superfamily
A8B88_RS07375	COG0583	DNA-binding transcription factor activity
A8B88_RS07410	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A8B88_RS07425	COG0667	Aldo Keto reductase
A8B88_RS07435	COG5265	(ABC) transporter
A8B88_RS07480	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A8B88_RS07485	COG0439	Biotin carboxylase
A8B88_RS07490	COG2188	Transcriptional regulator
A8B88_RS07525	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A8B88_RS07545	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
A8B88_RS07560	COG0500	methyltransferase
A8B88_RS07565	COG5265	(ABC) transporter
A8B88_RS07580	COG0028	Belongs to the TPP enzyme family
A8B88_RS07585	COG0440	acetolactate synthase activity
A8B88_RS07590	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A8B88_RS07595	COG1183	phosphatidylcholine synthase activity
A8B88_RS07605	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A8B88_RS07610	COG1185	polyribonucleotide nucleotidyltransferase activity
A8B88_RS07625	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A8B88_RS07645	COG0149	triose-phosphate isomerase activity
A8B88_RS07650	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A8B88_RS07660	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A8B88_RS07670	COG3799	methylaspartate ammonia-lyase activity
A8B88_RS07710	COG0583	DNA-binding transcription factor activity
A8B88_RS07715	COG0626	cystathionine gamma-synthase activity
A8B88_RS07720	COG3608	succinylglutamate desuccinylase aspartoacylase
A8B88_RS07740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8B88_RS07760	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
A8B88_RS07775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A8B88_RS07780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8B88_RS07785	COG1733	regulation of RNA biosynthetic process
A8B88_RS07795	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A8B88_RS07800	COG0583	DNA-binding transcription factor activity
A8B88_RS07805	COG1597	lipid kinase activity
A8B88_RS07815	COG0671	phosphoesterase, PA-phosphatase related
A8B88_RS07840	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A8B88_RS07845	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8B88_RS07850	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8B88_RS07855	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8B88_RS07860	COG0649	NAD binding
A8B88_RS07865	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A8B88_RS07875	COG1034	ATP synthesis coupled electron transport
A8B88_RS07880	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A8B88_RS07885	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8B88_RS07895	COG0713	ATP synthesis coupled electron transport
A8B88_RS07910	COG1007	ATP synthesis coupled electron transport
A8B88_RS07920	COG4774	siderophore transport
A8B88_RS07925	COG4774	siderophore transport
A8B88_RS07940	COG0028	Belongs to the TPP enzyme family
A8B88_RS07945	COG3181	Tripartite tricarboxylate transporter family receptor
A8B88_RS07950	COG0583	DNA-binding transcription factor activity
A8B88_RS07955	COG0560	Phosphoserine phosphatase
A8B88_RS07960	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A8B88_RS07965	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A8B88_RS07970	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A8B88_RS07980	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A8B88_RS07985	COG0308	aminopeptidase N
A8B88_RS08005	COG0028	Belongs to the TPP enzyme family
A8B88_RS08025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8B88_RS08035	COG0318	PFAM AMP-dependent synthetase and ligase
A8B88_RS08045	COG1802	Transcriptional regulator
A8B88_RS08055	COG1802	Transcriptional regulator
A8B88_RS08065	COG1028	Short-chain dehydrogenase reductase Sdr
A8B88_RS08085	COG1126	abc transporter atp-binding protein
A8B88_RS08090	COG0765	amino acid transport
A8B88_RS08110	COG1538	Outer membrane efflux protein
A8B88_RS08115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8B88_RS08120	COG2274	protein secretion by the type I secretion system
A8B88_RS08125	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
A8B88_RS08135	COG2994	toxin metabolic process
A8B88_RS08150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8B88_RS08155	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
A8B88_RS08165	COG0583	DNA-binding transcription factor activity
A8B88_RS08175	COG0142	geranyltranstransferase activity
A8B88_RS08185	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A8B88_RS08190	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A8B88_RS08195	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A8B88_RS08200	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A8B88_RS08240	COG3712	iron ion homeostasis
A8B88_RS08245	COG4774	siderophore transport
A8B88_RS08250	COG2353	YceI-like domain
A8B88_RS08270	COG0019	diaminopimelate decarboxylase activity
A8B88_RS08295	COG0601	transmembrane transport
A8B88_RS08300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8B88_RS08310	COG0154	amidase activity
A8B88_RS08315	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A8B88_RS08340	COG2154	pterin-4-alpha-carbinolamine dehydratase
A8B88_RS08350	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A8B88_RS08360	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A8B88_RS08365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A8B88_RS08370	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A8B88_RS08375	COG1929	Belongs to the glycerate kinase type-1 family
A8B88_RS08380	COG0469	pyruvate kinase activity
A8B88_RS08385	COG0700	Nucleoside recognition
A8B88_RS08415	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A8B88_RS08420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8B88_RS08435	COG0823	Involved in the tonB-independent uptake of proteins
A8B88_RS08445	COG0848	biopolymer transport protein
A8B88_RS08450	COG0811	peptide transport
A8B88_RS08455	COG0824	Thioesterase
A8B88_RS08460	COG0442	prolyl-tRNA aminoacylation
A8B88_RS08465	COG0494	nUDIX hydrolase
A8B88_RS08480	COG2135	peptidase activity
A8B88_RS08685	COG1464	Belongs to the NlpA lipoprotein family
A8B88_RS08715	COG4211	Belongs to the binding-protein-dependent transport system permease family
A8B88_RS08725	COG0154	amidase activity
A8B88_RS08730	COG0288	reversible hydration of carbon dioxide
A8B88_RS08745	COG0514	ATP-dependent DNA helicase (RecQ)
A8B88_RS08750	COG2255	four-way junction helicase activity
A8B88_RS08765	COG0632	four-way junction helicase activity
A8B88_RS08770	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A8B88_RS08790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A8B88_RS08800	COG0006	proline dipeptidase activity
A8B88_RS08825	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A8B88_RS08840	COG4783	chaperone-mediated protein folding
A8B88_RS08845	COG0429	hydrolase of the alpha beta-hydrolase fold
A8B88_RS08875	COG0513	Belongs to the DEAD box helicase family
A8B88_RS08895	COG1546	Belongs to the CinA family
A8B88_RS08895	COG1058	Belongs to the CinA family
A8B88_RS08900	COG1414	Transcriptional regulator
A8B88_RS08920	COG0167	dihydroorotate dehydrogenase activity
A8B88_RS08925	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A8B88_RS08930	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A8B88_RS08940	COG0583	DNA-binding transcription factor activity
A8B88_RS09000	COG0280	phosphate acetyltransferase
A8B88_RS09000	COG0281	malic enzyme
A8B88_RS09010	COG0601	transmembrane transport
A8B88_RS09015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8B88_RS09020	COG4172	Belongs to the ABC transporter superfamily
A8B88_RS09050	COG0640	Transcriptional regulator
A8B88_RS09065	COG3135	benzoate transporter
A8B88_RS09070	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A8B88_RS09075	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A8B88_RS09080	COG0742	ribosomal rna small subunit methyltransferase
A8B88_RS09100	COG3639	organic phosphonate transmembrane transporter activity
A8B88_RS09105	COG3639	organic phosphonate transmembrane transporter activity
A8B88_RS09110	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A8B88_RS09145	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A8B88_RS09150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A8B88_RS09160	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A8B88_RS09165	COG1546	Belongs to the CinA family
A8B88_RS09165	COG1058	Belongs to the CinA family
A8B88_RS09170	COG0284	orotidine-5'-phosphate decarboxylase activity
A8B88_RS09175	COG1252	NADH dehydrogenase
A8B88_RS09190	COG3468	outer membrane autotransporter barrel domain protein
A8B88_RS09195	COG0459	protein refolding
A8B88_RS09200	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A8B88_RS09220	COG1053	succinate dehydrogenase
A8B88_RS09230	COG0583	DNA-binding transcription factor activity
A8B88_RS09235	COG1053	succinate dehydrogenase
A8B88_RS09255	COG3706	GGDEF domain
A8B88_RS09290	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A8B88_RS09295	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
A8B88_RS09305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A8B88_RS09315	COG0069	glutamate synthase activity
A8B88_RS09320	COG2391	methyltransferase activity
A8B88_RS09325	COG0679	Auxin Efflux Carrier
A8B88_RS09350	COG0557	exoribonuclease II activity
A8B88_RS09355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A8B88_RS09365	COG3128	pkhd-type hydroxylase
A8B88_RS09370	COG0776	regulation of translation
A8B88_RS09400	COG0642	Histidine kinase
A8B88_RS09405	COG3158	transport of potassium into the cell
A8B88_RS09410	COG0137	argininosuccinate synthase activity
A8B88_RS09415	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A8B88_RS09420	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A8B88_RS09430	COG0583	DNA-binding transcription factor activity
A8B88_RS09440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8B88_RS09460	COG2186	Transcriptional regulator
A8B88_RS09470	COG2223	nitrite transmembrane transporter activity
A8B88_RS09480	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A8B88_RS09485	COG0450	alkyl hydroperoxide reductase
A8B88_RS09505	COG1214	PFAM Peptidase M22, glycoprotease
A8B88_RS09510	COG1573	uracil-dna glycosylase
A8B88_RS09515	COG0477	Major facilitator Superfamily
A8B88_RS09520	COG1196	nuclear chromosome segregation
A8B88_RS09530	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A8B88_RS09535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A8B88_RS09550	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A8B88_RS09555	COG1122	ATPase activity
A8B88_RS09560	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A8B88_RS09565	COG1268	BioY protein
A8B88_RS09585	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A8B88_RS09620	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A8B88_RS09625	COG2878	Part of a membrane complex involved in electron transport
A8B88_RS09640	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A8B88_RS09645	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A8B88_RS09650	COG0251	oxidation-reduction process
A8B88_RS09660	COG3228	Belongs to the MtfA family
A8B88_RS09665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A8B88_RS09675	COG0133	tryptophan synthase activity
A8B88_RS09680	COG0159	tryptophan synthase activity
A8B88_RS09685	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A8B88_RS09690	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A8B88_RS09705	COG1530	ribonuclease E activity
A8B88_RS09715	COG0546	phosphoglycolate phosphatase activity
A8B88_RS09720	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A8B88_RS09725	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
A8B88_RS09735	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B88_RS09740	COG0583	DNA-binding transcription factor activity
A8B88_RS09750	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B88_RS09775	COG0251	oxidation-reduction process
A8B88_RS09780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A8B88_RS09780	COG1017	nitric oxide dioxygenase activity
A8B88_RS09785	COG2031	fatty acid transporter
A8B88_RS09790	COG1012	belongs to the aldehyde dehydrogenase family
A8B88_RS09795	COG1802	Transcriptional regulator
A8B88_RS09805	COG1278	Cold shock
A8B88_RS09810	COG0583	DNA-binding transcription factor activity
A8B88_RS09830	COG0183	Belongs to the thiolase family
A8B88_RS09840	COG1960	acyl-CoA dehydrogenase activity
A8B88_RS09845	COG0583	DNA-binding transcription factor activity
A8B88_RS09850	COG3181	Tripartite tricarboxylate transporter family receptor
A8B88_RS09855	COG1024	Enoyl-CoA hydratase
A8B88_RS09860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B88_RS09865	COG1253	flavin adenine dinucleotide binding
A8B88_RS09870	COG1285	pathogenesis
A8B88_RS09880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8B88_RS09895	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A8B88_RS09905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8B88_RS09915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B88_RS09920	COG3181	Tripartite tricarboxylate transporter family receptor
A8B88_RS09925	COG1960	acyl-CoA dehydrogenase activity
A8B88_RS09945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A8B88_RS09950	COG1024	Enoyl-CoA hydratase
A8B88_RS09955	COG1960	acyl-CoA dehydrogenase activity
A8B88_RS09975	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A8B88_RS09980	COG0022	dehydrogenase e1 component
A8B88_RS09985	COG1024	Enoyl-CoA hydratase
A8B88_RS09990	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8B88_RS10010	COG0683	leucine binding
A8B88_RS10015	COG0559	Belongs to the binding-protein-dependent transport system permease family
A8B88_RS10020	COG0411	ABC transporter
A8B88_RS10030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A8B88_RS10045	COG3181	Tripartite tricarboxylate transporter family receptor
A8B88_RS10070	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A8B88_RS10080	COG4942	peptidase
A8B88_RS10085	COG0588	phosphoglycerate mutase activity
A8B88_RS10090	COG1054	Belongs to the UPF0176 family
A8B88_RS10095	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A8B88_RS10100	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A8B88_RS10105	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A8B88_RS10110	COG3181	Tripartite tricarboxylate transporter family receptor
A8B88_RS10145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8B88_RS10150	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A8B88_RS10175	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A8B88_RS10200	COG1335	isochorismatase
A8B88_RS10205	COG2309	aminopeptidase activity
A8B88_RS10210	COG0596	Alpha beta hydrolase
A8B88_RS10215	COG3473	Maleate cis-trans isomerase
A8B88_RS10225	COG2068	MobA-Related Protein
A8B88_RS10250	COG2204	response regulator
A8B88_RS10255	COG5000	phosphorelay sensor kinase activity
A8B88_RS10265	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A8B88_RS10265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A8B88_RS10275	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
A8B88_RS10295	COG0583	DNA-binding transcription factor activity
A8B88_RS10310	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A8B88_RS10315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8B88_RS10320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8B88_RS10335	COG0758	DNA mediated transformation
A8B88_RS10340	COG1522	sequence-specific DNA binding
A8B88_RS10350	COG0242	peptide deformylase activity
A8B88_RS10360	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A8B88_RS10370	COG0546	phosphoglycolate phosphatase activity
A8B88_RS10390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A8B88_RS10395	COG1942	4-Oxalocrotonate Tautomerase
A8B88_RS10400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8B88_RS10420	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A8B88_RS10440	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A8B88_RS10445	COG1024	Enoyl-CoA hydratase
A8B88_RS10450	COG1414	Transcriptional regulator
A8B88_RS10455	COG0318	PFAM AMP-dependent synthetase and ligase
A8B88_RS10460	COG3181	Tripartite tricarboxylate transporter family receptor
A8B88_RS10490	COG0583	DNA-binding transcription factor activity
A8B88_RS10505	COG3422	double-strand break repair
A8B88_RS10510	COG0330	HflC and HflK could
A8B88_RS10520	COG0251	oxidation-reduction process
A8B88_RS10565	COG3723	Recombinational DNA repair protein, rece pathway
A8B88_RS10600	COG0582	viral genome integration into host DNA
A8B88_RS10625	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A8B88_RS10635	COG0706	membrane insertase activity
A8B88_RS10640	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A8B88_RS10645	COG0594	ribonuclease P activity
A8B88_RS10650	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A8B88_RS10655	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A8B88_RS10670	COG1414	Transcriptional regulator
A8B88_RS10675	COG0154	amidase activity
A8B88_RS10690	COG1304	FMN binding
A8B88_RS10710	COG1960	acyl-CoA dehydrogenase activity
A8B88_RS10730	COG1960	acyl-CoA dehydrogenase activity
A8B88_RS10740	COG0183	Belongs to the thiolase family
A8B88_RS10745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A8B88_RS10760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A8B88_RS10765	COG3181	Tripartite tricarboxylate transporter family receptor
A8B88_RS10775	COG2358	TRAP transporter, solute receptor (TAXI family
A8B88_RS10785	COG1629	transport
A8B88_RS10790	COG2922	Belongs to the Smg family
A8B88_RS10815	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A8B88_RS10820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8B88_RS10825	COG1028	Short-chain dehydrogenase reductase Sdr
A8B88_RS10830	COG1012	belongs to the aldehyde dehydrogenase family
A8B88_RS10840	COG0028	Belongs to the TPP enzyme family
A8B88_RS10845	COG1522	sequence-specific DNA binding
A8B88_RS10850	COG3781	membrane
A8B88_RS10860	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A8B88_RS10880	COG4206	TonB-dependent receptor
A8B88_RS10885	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8B88_RS10890	COG2022	thiamine diphosphate biosynthetic process
A8B88_RS10895	COG0351	phosphomethylpyrimidine kinase
A8B88_RS10900	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A8B88_RS10915	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A8B88_RS10925	COG0628	permease
A8B88_RS10935	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A8B88_RS10945	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A8B88_RS10950	COG0049	tRNA binding
A8B88_RS10955	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A8B88_RS10960	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A8B88_RS10965	COG0051	transcription antitermination factor activity, RNA binding
A8B88_RS10970	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A8B88_RS10975	COG0088	Forms part of the polypeptide exit tunnel
A8B88_RS10980	COG0089	rRNA binding
A8B88_RS10985	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A8B88_RS10990	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A8B88_RS10995	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A8B88_RS11000	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A8B88_RS11005	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A8B88_RS11010	COG0255	Belongs to the universal ribosomal protein uL29 family
A8B88_RS11015	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A8B88_RS11035	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A8B88_RS11040	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A8B88_RS11045	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A8B88_RS11050	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A8B88_RS11055	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A8B88_RS11060	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A8B88_RS11065	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A8B88_RS11070	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A8B88_RS11075	COG1841	ribosomal large subunit assembly
A8B88_RS11080	COG0200	Binds to the 23S rRNA
A8B88_RS11085	COG0201	protein transport
A8B88_RS11090	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A8B88_RS11095	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A8B88_RS11100	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A8B88_RS11105	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A8B88_RS11110	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A8B88_RS11115	COG0202	RNA polymerase activity
A8B88_RS11120	COG0203	ribosomal protein L17
A8B88_RS11130	COG1324	tolerance protein
A8B88_RS11150	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A8B88_RS11160	COG1333	cytochrome c biogenesis protein
A8B88_RS11165	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A8B88_RS11175	COG1965	Belongs to the frataxin family
A8B88_RS11185	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A8B88_RS11190	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A8B88_RS11195	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A8B88_RS11210	COG2814	Major facilitator Superfamily
A8B88_RS11215	COG0629	single-stranded DNA binding
A8B88_RS11255	COG0402	S-adenosylhomocysteine deaminase activity
A8B88_RS11265	COG0438	transferase activity, transferring glycosyl groups
A8B88_RS11285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8B88_RS11310	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A8B88_RS11315	COG2186	Transcriptional regulator
A8B88_RS11335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8B88_RS11340	COG1956	GAF domain-containing protein
A8B88_RS11345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8B88_RS11355	COG1652	LysM domain
A8B88_RS11370	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A8B88_RS11385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A8B88_RS11415	COG3181	Tripartite tricarboxylate transporter family receptor
A8B88_RS11430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8B88_RS11445	COG1024	Enoyl-CoA hydratase
A8B88_RS11465	COG1309	transcriptional regulator
A8B88_RS11470	COG2816	NAD+ diphosphatase activity
A8B88_RS11475	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A8B88_RS11560	COG2814	Major facilitator Superfamily
A8B88_RS11565	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A8B88_RS11585	COG1999	signal sequence binding
A8B88_RS11590	COG0109	protoheme IX farnesyltransferase activity
A8B88_RS11630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A8B88_RS11650	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A8B88_RS11655	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A8B88_RS11665	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A8B88_RS11670	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A8B88_RS11680	COG0070	glutamate synthase
A8B88_RS11680	COG0069	glutamate synthase activity
A8B88_RS11680	COG0067	glutamate synthase
A8B88_RS11690	COG3047	cAMP biosynthetic process
A8B88_RS11700	COG1127	ABC transporter
A8B88_RS11705	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A8B88_RS11710	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A8B88_RS11715	COG2853	Lipoprotein
A8B88_RS11725	COG1131	(ABC) transporter
A8B88_RS11730	COG0842	Transport permease protein
A8B88_RS11740	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A8B88_RS11745	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A8B88_RS11750	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A8B88_RS11755	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A8B88_RS11760	COG0131	Imidazoleglycerol-phosphate dehydratase
A8B88_RS11765	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A8B88_RS11770	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A8B88_RS11775	COG0107	imidazoleglycerol-phosphate synthase activity
A8B88_RS11780	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A8B88_RS11785	COG0140	phosphoribosyl-ATP diphosphatase activity
A8B88_RS11790	COG0537	adenosine 5'-monophosphoramidase activity
A8B88_RS11795	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A8B88_RS11800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A8B88_RS11815	COG3181	Tripartite tricarboxylate transporter family receptor
A8B88_RS11850	COG3702	type iv secretory pathway
A8B88_RS11855	COG3451	type IV secretory pathway VirB4
A8B88_RS11870	COG3736	Type IV secretory pathway, component VirB8
A8B88_RS11875	COG3504	Conjugal transfer protein
A8B88_RS11880	COG2948	multi-organism process
A8B88_RS11885	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
A8B88_RS11895	COG0697	spore germination
A8B88_RS11915	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A8B88_RS11920	COG0747	negative chemotaxis
A8B88_RS11925	COG0601	transmembrane transport
A8B88_RS11930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8B88_RS11935	COG0444	Belongs to the ABC transporter superfamily
A8B88_RS11945	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A8B88_RS11955	COG0494	nUDIX hydrolase
A8B88_RS11995	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
A8B88_RS12000	COG0237	dephospho-CoA kinase activity
A8B88_RS12005	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A8B88_RS12020	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A8B88_RS12025	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A8B88_RS12035	COG0477	Major facilitator Superfamily
A8B88_RS12040	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A8B88_RS12055	COG1126	abc transporter atp-binding protein
A8B88_RS12060	COG0765	amino acid transport
A8B88_RS12065	COG4597	amino acid ABC transporter
A8B88_RS12070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8B88_RS12075	COG2884	Cell division ATP-binding protein ftsE
A8B88_RS12085	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A8B88_RS12095	COG1194	a g-specific adenine glycosylase
A8B88_RS12105	COG2226	methyltransferase
A8B88_RS12115	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B88_RS12135	COG1024	Enoyl-CoA hydratase
A8B88_RS12155	COG1024	Enoyl-CoA hydratase
A8B88_RS12160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B88_RS12165	COG3181	Tripartite tricarboxylate transporter family receptor
A8B88_RS12175	COG0753	catalase activity
A8B88_RS12180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8B88_RS12185	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A8B88_RS12195	COG2175	clavaminate synthase activity
A8B88_RS12200	COG1473	amidohydrolase
A8B88_RS12205	COG4608	Belongs to the ABC transporter superfamily
A8B88_RS12210	COG0444	Belongs to the ABC transporter superfamily
A8B88_RS12225	COG0747	negative chemotaxis
A8B88_RS12230	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A8B88_RS12265	COG0436	Aminotransferase
A8B88_RS12270	COG1278	Cold shock
A8B88_RS12275	COG0445	tRNA wobble uridine modification
A8B88_RS12280	COG0357	Ribosomal RNA small subunit methyltransferase G
A8B88_RS12285	COG1192	Involved in chromosome partitioning
A8B88_RS12295	COG1475	DNA binding
A8B88_RS12300	COG0252	asparaginase activity
A8B88_RS12325	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A8B88_RS12335	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A8B88_RS12345	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A8B88_RS12350	COG0081	regulation of translation
A8B88_RS12355	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A8B88_RS12360	COG0222	ribosome binding
A8B88_RS12365	COG0085	RNA polymerase activity
A8B88_RS12370	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A8B88_RS12410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B88_RS12435	COG1024	Enoyl-CoA hydratase
A8B88_RS12455	COG0752	glycyl-tRNA synthetase alpha subunit
A8B88_RS12465	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A8B88_RS12470	COG0204	Acyl-transferase
A8B88_RS12485	COG0242	peptide deformylase activity
A8B88_RS12520	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A8B88_RS12525	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A8B88_RS12530	COG2813	Specifically methylates the guanine in position
A8B88_RS12530	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A8B88_RS12540	COG2223	nitrite transmembrane transporter activity
A8B88_RS12550	COG1794	racemase activity, acting on amino acids and derivatives
A8B88_RS12555	COG1126	abc transporter atp-binding protein
A8B88_RS12560	COG0765	amino acid transport
A8B88_RS12565	COG0765	amino acid transport
A8B88_RS12570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8B88_RS12630	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8B88_RS12660	COG0326	Molecular chaperone. Has ATPase activity
A8B88_RS12665	COG0625	glutathione transferase activity
A8B88_RS12680	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A8B88_RS12685	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A8B88_RS12715	COG0438	transferase activity, transferring glycosyl groups
A8B88_RS12720	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A8B88_RS12725	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A8B88_RS12755	COG0859	PFAM glycosyl transferase family 9
A8B88_RS12770	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A8B88_RS12780	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A8B88_RS12785	COG1127	ABC transporter
A8B88_RS12810	COG1686	Belongs to the peptidase S11 family
A8B88_RS12820	COG2921	Belongs to the UPF0250 family
A8B88_RS12825	COG0321	lipoyl(octanoyl) transferase activity
A8B88_RS12830	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A8B88_RS12865	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A8B88_RS12875	COG0018	arginyl-trna synthetase
A8B88_RS12895	COG0395	ABC-type sugar transport system, permease component
A8B88_RS12900	COG1175	transmembrane transport
A8B88_RS12905	COG1653	transport
A8B88_RS12910	COG3842	ATPase activity
A8B88_RS12915	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A8B88_RS12925	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A8B88_RS12945	COG1609	Transcriptional regulator
A8B88_RS12955	COG0154	amidase activity
A8B88_RS12960	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A8B88_RS12970	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A8B88_RS12980	COG0583	DNA-binding transcription factor activity
A8B88_RS12995	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A8B88_RS13000	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A8B88_RS13015	COG1802	Transcriptional regulator
A8B88_RS13030	COG1024	Enoyl-CoA hydratase
A8B88_RS13045	COG3181	Tripartite tricarboxylate transporter family receptor
A8B88_RS13060	COG1984	allophanate hydrolase subunit 2
A8B88_RS13065	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A8B88_RS13075	COG0583	DNA-binding transcription factor activity
A8B88_RS13080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8B88_RS13090	COG5002	protein histidine kinase activity
A8B88_RS13100	COG5002	protein histidine kinase activity
A8B88_RS13105	COG0745	RESPONSE REGULATOR receiver
A8B88_RS13110	COG2226	methyltransferase
A8B88_RS13125	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A8B88_RS13145	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A8B88_RS13155	COG0513	Belongs to the DEAD box helicase family
A8B88_RS13160	COG1280	lysine exporter protein (LysE YggA)
A8B88_RS13165	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A8B88_RS13200	COG1054	Belongs to the UPF0176 family
A8B88_RS13205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8B88_RS13205	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8B88_RS13215	COG0489	protein tyrosine kinase activity
A8B88_RS13230	COG0717	Belongs to the dCTP deaminase family
A8B88_RS13260	COG2081	HI0933 family
A8B88_RS13270	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A8B88_RS13280	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A8B88_RS13285	COG0509	glycine decarboxylation via glycine cleavage system
A8B88_RS13290	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A8B88_RS13290	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A8B88_RS13330	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A8B88_RS13345	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A8B88_RS13355	COG1414	Transcriptional regulator
A8B88_RS13360	COG1028	Short-chain dehydrogenase reductase Sdr
A8B88_RS13365	COG2031	fatty acid transporter
A8B88_RS13370	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8B88_RS13380	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A8B88_RS13385	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A8B88_RS13395	COG4257	antibiotic catabolic process
A8B88_RS13415	COG1012	belongs to the aldehyde dehydrogenase family
A8B88_RS13420	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A8B88_RS13425	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A8B88_RS13450	COG1028	Short-chain dehydrogenase reductase Sdr
A8B88_RS13460	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A8B88_RS13470	COG2188	Transcriptional regulator
A8B88_RS13475	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A8B88_RS13500	COG0617	tRNA 3'-terminal CCA addition
A8B88_RS13515	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A8B88_RS13520	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A8B88_RS13525	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A8B88_RS13530	COG0586	Pfam SNARE associated Golgi protein
A8B88_RS13535	COG0860	N-Acetylmuramoyl-L-alanine amidase
A8B88_RS13540	COG0802	atpase or kinase
A8B88_RS13545	COG0114	fumarate hydratase activity
A8B88_RS13555	COG3181	Tripartite tricarboxylate transporter family receptor
A8B88_RS13570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B88_RS13580	COG1960	acyl-CoA dehydrogenase activity
A8B88_RS13605	COG1294	oxidase, subunit
A8B88_RS13615	COG4988	ABC transporter
A8B88_RS13620	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A8B88_RS13625	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A8B88_RS13640	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A8B88_RS13670	COG0625	glutathione transferase activity
A8B88_RS13675	COG2857	Cytochrome c1
A8B88_RS13680	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A8B88_RS13685	COG0723	plastoquinol--plastocyanin reductase activity
A8B88_RS13690	COG1970	mechanosensitive ion channel activity
A8B88_RS13695	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A8B88_RS13710	COG2808	Putative FMN-binding domain
A8B88_RS13715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8B88_RS13720	COG0747	negative chemotaxis
A8B88_RS13725	COG0657	acetylesterase activity
A8B88_RS13735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A8B88_RS13740	COG2207	Transcriptional regulator
A8B88_RS13745	COG0129	dihydroxy-acid dehydratase activity
A8B88_RS13750	COG2814	Major facilitator Superfamily
A8B88_RS13755	COG0583	DNA-binding transcription factor activity
A8B88_RS13765	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
A8B88_RS13835	COG1024	Enoyl-CoA hydratase
A8B88_RS13840	COG1960	acyl-CoA dehydrogenase activity
A8B88_RS13865	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A8B88_RS13870	COG0352	thiamine-phosphate diphosphorylase activity
A8B88_RS13885	COG1678	Uncharacterized ACR, COG1678
A8B88_RS13890	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A8B88_RS13895	COG0540	Belongs to the ATCase OTCase family
A8B88_RS13910	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A8B88_RS13920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A8B88_RS13955	COG1234	tRNA 3'-trailer cleavage
A8B88_RS14000	COG1683	Conserved Protein
A8B88_RS14005	COG1120	ATPase activity
A8B88_RS14010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8B88_RS14015	COG4558	Periplasmic binding protein
A8B88_RS14020	COG3720	iron ion transport
A8B88_RS14030	COG3712	iron ion homeostasis
A8B88_RS14035	COG1595	DNA-templated transcription, initiation
A8B88_RS14070	COG1802	Transcriptional regulator
A8B88_RS14080	COG3069	C4-dicarboxylate transmembrane transporter activity
A8B88_RS14090	COG1012	belongs to the aldehyde dehydrogenase family
A8B88_RS14125	COG2860	membrane
A8B88_RS14130	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A8B88_RS14135	COG0708	Exodeoxyribonuclease III
A8B88_RS14140	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A8B88_RS14145	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A8B88_RS14150	COG0154	amidase activity
A8B88_RS14155	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A8B88_RS14160	COG1077	Cell shape determining protein MreB Mrl
A8B88_RS14165	COG1792	Involved in formation and maintenance of cell shape
A8B88_RS14175	COG0768	penicillin binding
A8B88_RS14180	COG0772	Belongs to the SEDS family
A8B88_RS14185	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A8B88_RS14190	COG0471	metal ion transport
A8B88_RS14195	COG1309	transcriptional regulator
A8B88_RS14205	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A8B88_RS14220	COG2823	Periplasmic or secreted lipoprotein
A8B88_RS14225	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A8B88_RS14240	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A8B88_RS14260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B88_RS14270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B88_RS14295	COG0492	ferredoxin-NADP+ reductase activity
A8B88_RS14305	COG3181	Tripartite tricarboxylate transporter family receptor
A8B88_RS14310	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8B88_RS14310	COG1024	Enoyl-CoA hydratase
A8B88_RS14315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B88_RS14320	COG0028	Belongs to the TPP enzyme family
A8B88_RS14345	COG3181	Tripartite tricarboxylate transporter family receptor
A8B88_RS14355	COG0697	spore germination
A8B88_RS14380	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A8B88_RS14385	COG0463	Glycosyl transferase, family 2
A8B88_RS14400	COG0786	glutamate:sodium symporter activity
A8B88_RS14410	COG2031	fatty acid transporter
A8B88_RS14425	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A8B88_RS14430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A8B88_RS14450	COG3181	Tripartite tricarboxylate transporter family receptor
A8B88_RS14460	COG0277	FAD linked oxidase domain protein
A8B88_RS14465	COG1960	acyl-CoA dehydrogenase activity
A8B88_RS14470	COG1960	acyl-CoA dehydrogenase activity
A8B88_RS14480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8B88_RS14495	COG2072	flavoprotein involved in K transport
A8B88_RS14500	COG0604	alcohol dehydrogenase
A8B88_RS14515	COG1024	Enoyl-CoA hydratase
A8B88_RS14535	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A8B88_RS14540	COG1522	sequence-specific DNA binding
A8B88_RS14545	COG0183	Belongs to the thiolase family
A8B88_RS14555	COG1960	acyl-CoA dehydrogenase activity
A8B88_RS14600	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A8B88_RS14605	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A8B88_RS14610	COG2890	protein-(glutamine-N5) methyltransferase activity
A8B88_RS14615	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A8B88_RS14625	COG3181	Tripartite tricarboxylate transporter family receptor
A8B88_RS14665	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A8B88_RS14670	COG1660	Displays ATPase and GTPase activities
A8B88_RS14680	COG2010	Cytochrome c
A8B88_RS14680	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A8B88_RS14685	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A8B88_RS14695	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A8B88_RS14700	COG1137	ATPase activity
A8B88_RS14715	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A8B88_RS14725	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A8B88_RS14760	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A8B88_RS14765	COG3568	Endonuclease Exonuclease Phosphatase
A8B88_RS14770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A8B88_RS14800	COG0154	amidase activity
A8B88_RS14810	COG1414	Transcriptional regulator
A8B88_RS14825	COG1024	Enoyl-CoA hydratase
A8B88_RS14825	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8B88_RS14835	COG2132	Multicopper oxidase
A8B88_RS14865	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8B88_RS14890	COG1024	Enoyl-CoA hydratase
A8B88_RS14895	COG1024	Enoyl-CoA hydratase
A8B88_RS14900	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A8B88_RS14920	COG0601	transmembrane transport
A8B88_RS14925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8B88_RS14930	COG4608	Belongs to the ABC transporter superfamily
A8B88_RS14940	COG2195	Cleaves the N-terminal amino acid of tripeptides
A8B88_RS14950	COG0210	DNA helicase
A8B88_RS14955	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A8B88_RS14960	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A8B88_RS14970	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A8B88_RS14975	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A8B88_RS14980	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A8B88_RS14985	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A8B88_RS14990	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A8B88_RS14995	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A8B88_RS15005	COG0356	it plays a direct role in the translocation of protons across the membrane
A8B88_RS15030	COG1024	Enoyl-CoA hydratase
A8B88_RS15035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8B88_RS15040	COG3634	alkyl hydroperoxide reductase activity
A8B88_RS15050	COG0037	tRNA processing
A8B88_RS15060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8B88_RS15065	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A8B88_RS15070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A8B88_RS15075	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A8B88_RS15080	COG2967	ApaG domain
A8B88_RS15085	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A8B88_RS15090	COG0546	phosphoglycolate phosphatase activity
A8B88_RS15100	COG0512	Glutamine amidotransferase of anthranilate synthase
A8B88_RS15105	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A8B88_RS15110	COG0134	indole-3-glycerol-phosphate synthase activity
A8B88_RS15135	COG1960	acyl-CoA dehydrogenase activity
A8B88_RS15140	COG0583	DNA-binding transcription factor activity
A8B88_RS15155	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A8B88_RS15160	COG0259	pyridoxamine-phosphate oxidase activity
A8B88_RS15170	COG2814	Major facilitator Superfamily
A8B88_RS15175	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A8B88_RS15180	COG2188	Transcriptional regulator
A8B88_RS15185	COG0318	PFAM AMP-dependent synthetase and ligase
A8B88_RS15205	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A8B88_RS15215	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A8B88_RS15230	COG1215	transferase activity, transferring glycosyl groups
A8B88_RS15240	COG0601	transmembrane transport
A8B88_RS15250	COG0488	(ABC) transporter
A8B88_RS15270	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A8B88_RS15275	COG2894	cell division
A8B88_RS15280	COG0850	regulation of cytokinetic process
A8B88_RS15285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A8B88_RS15290	COG1271	oxidase subunit
A8B88_RS15325	COG2979	Protein of unknown function (DUF533)
A8B88_RS15345	COG0741	lytic transglycosylase activity
A8B88_RS15345	COG1388	LysM domain
A8B88_RS15350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8B88_RS15355	COG2226	methyltransferase
A8B88_RS15360	COG0328	RNA-DNA hybrid ribonuclease activity
A8B88_RS15405	COG2030	dehydratase
A8B88_RS15410	COG0183	Belongs to the thiolase family
A8B88_RS15455	COG1960	acyl-CoA dehydrogenase activity
A8B88_RS15470	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B88_RS15475	COG1028	Short-chain dehydrogenase reductase Sdr
A8B88_RS15490	COG2718	Belongs to the UPF0229 family
A8B88_RS15495	COG2719	SpoVR family
A8B88_RS15520	COG2188	Transcriptional regulator
A8B88_RS15535	COG0633	Ferredoxin
A8B88_RS15545	COG0829	nickel cation binding
A8B88_RS15550	COG0831	urea catabolic process
A8B88_RS15560	COG0832	Belongs to the urease beta subunit family
A8B88_RS15565	COG0804	urea catabolic process
A8B88_RS15575	COG0830	nickel cation binding
A8B88_RS15580	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A8B88_RS15600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8B88_RS15605	COG0601	transmembrane transport
A8B88_RS15610	COG0747	negative chemotaxis
A8B88_RS15620	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A8B88_RS15625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8B88_RS15635	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A8B88_RS15645	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
A8B88_RS15650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A8B88_RS15655	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A8B88_RS15670	COG0438	transferase activity, transferring glycosyl groups
A8B88_RS15685	COG0438	transferase activity, transferring glycosyl groups
A8B88_RS15690	COG0438	transferase activity, transferring glycosyl groups
A8B88_RS15695	COG0166	Belongs to the GPI family
A8B88_RS15710	COG0277	FAD linked oxidase domain protein
A8B88_RS15715	COG0745	RESPONSE REGULATOR receiver
A8B88_RS15720	COG0642	Histidine kinase
A8B88_RS15725	COG1368	sulfuric ester hydrolase activity
A8B88_RS15735	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
A8B88_RS15760	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A8B88_RS15770	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A8B88_RS15775	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A8B88_RS15785	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A8B88_RS15790	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A8B88_RS15795	COG0193	aminoacyl-tRNA hydrolase activity
A8B88_RS15805	COG0012	GTP binding
A8B88_RS15810	COG0582	viral genome integration into host DNA
A8B88_RS15830	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A8B88_RS15875	COG0745	RESPONSE REGULATOR receiver
A8B88_RS15890	COG1309	transcriptional regulator
A8B88_RS15915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8B88_RS15925	COG0405	Gamma-glutamyltransferase
A8B88_RS15940	COG1280	lysine exporter protein (LysE YggA)
A8B88_RS16000	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A8B88_RS16005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A8B88_RS16015	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A8B88_RS16020	COG0513	Belongs to the DEAD box helicase family
A8B88_RS16030	COG0617	tRNA 3'-terminal CCA addition
A8B88_RS16045	COG0477	Major facilitator Superfamily
A8B88_RS16055	COG0583	DNA-binding transcription factor activity
A8B88_RS16070	COG1950	PFAM Membrane protein of
A8B88_RS16075	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A8B88_RS16090	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A8B88_RS16100	COG1560	Kdo2-lipid A biosynthetic process
A8B88_RS16105	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A8B88_RS16115	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A8B88_RS16125	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
A8B88_RS16135	COG0803	Belongs to the bacterial solute-binding protein 9 family
A8B88_RS16155	COG0735	belongs to the Fur family
A8B88_RS16160	COG0523	cobalamin synthesis protein
A8B88_RS16170	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A8B88_RS16175	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A8B88_RS16185	COG2096	Adenosyltransferase
A8B88_RS16200	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A8B88_RS16205	COG2084	Dehydrogenase
A8B88_RS16255	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A8B88_RS16260	COG0129	dihydroxy-acid dehydratase activity
A8B88_RS16265	COG4654	Cytochrome c, class I
A8B88_RS16270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A8B88_RS16320	COG1473	amidohydrolase
A8B88_RS16325	COG0418	dihydroorotase activity
A8B88_RS16330	COG0488	(ABC) transporter
A8B88_RS16340	COG2001	Belongs to the MraZ family
A8B88_RS16345	COG0275	rRNA processing
A8B88_RS16350	COG3116	cell division
A8B88_RS16360	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A8B88_RS16365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A8B88_RS16370	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A8B88_RS16380	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A8B88_RS16385	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A8B88_RS16390	COG1181	Belongs to the D-alanine--D-alanine ligase family
A8B88_RS16395	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A8B88_RS16405	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A8B88_RS16410	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A8B88_RS16420	COG0739	heme binding
A8B88_RS16425	COG0653	protein targeting
A8B88_RS16445	COG1028	Short-chain dehydrogenase reductase Sdr
A8B88_RS16450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8B88_RS16455	COG1522	sequence-specific DNA binding
A8B88_RS16475	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A8B88_RS16485	COG0557	exoribonuclease II activity
A8B88_RS16490	COG3150	esterase
A8B88_RS16495	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A8B88_RS16500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8B88_RS16505	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A8B88_RS16510	COG0511	ligase activity, forming carbon-carbon bonds
A8B88_RS16515	COG0439	Biotin carboxylase
A8B88_RS16520	COG2264	protein methyltransferase activity
A8B88_RS16530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8B88_RS16555	COG1696	Membrane protein involved in D-alanine export
A8B88_RS16560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8B88_RS16595	COG1522	sequence-specific DNA binding
A8B88_RS16610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A8B88_RS16615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8B88_RS16615	COG1042	CoA-binding domain protein
A8B88_RS16615	COG0045	succinate-CoA ligase (ADP-forming) activity
A8B88_RS16625	COG1802	Transcriptional regulator
A8B88_RS16630	COG3069	C4-dicarboxylate transmembrane transporter activity
A8B88_RS16635	COG0513	Belongs to the DEAD box helicase family
A8B88_RS16640	COG0346	lactoylglutathione lyase activity
A8B88_RS16645	COG1335	isochorismatase
A8B88_RS16650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8B88_RS16655	COG1116	anion transmembrane transporter activity
A8B88_RS16670	COG3028	Belongs to the UPF0307 family
A8B88_RS16675	COG0312	modulator of DNA gyrase
A8B88_RS16680	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A8B88_RS16685	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A8B88_RS16690	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A8B88_RS16695	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A8B88_RS16705	COG0316	Belongs to the HesB IscA family
A8B88_RS16710	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A8B88_RS16725	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A8B88_RS16735	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A8B88_RS16740	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A8B88_RS16755	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A8B88_RS16755	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A8B88_RS16785	COG0583	DNA-binding transcription factor activity
A8B88_RS16790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B88_RS16825	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
A8B88_RS16835	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A8B88_RS16840	COG1845	cytochrome c oxidase, subunit III
A8B88_RS16845	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A8B88_RS16850	COG0640	Transcriptional regulator
A8B88_RS16870	COG3220	belongs to the UPF0276 family
A8B88_RS16915	COG1666	GTP binding
A8B88_RS16950	COG0312	modulator of DNA gyrase
A8B88_RS16955	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A8B88_RS16960	COG3210	domain, Protein
A8B88_RS16960	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
A8B88_RS16960	COG3064	Membrane
A8B88_RS16960	COG3210	domain, Protein
A8B88_RS16960	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
A8B88_RS16960	COG3064	Membrane
A8B88_RS16965	COG0277	FAD linked oxidase domain protein
A8B88_RS16970	COG0277	FAD linked oxidase domain protein
A8B88_RS16975	COG0277	FAD linked oxidase domain protein
A8B88_RS16980	COG0247	lactate metabolic process
A8B88_RS16985	COG2819	hydrolase of the alpha beta superfamily
A8B88_RS17020	COG0583	DNA-binding transcription factor activity
A8B88_RS17025	COG0482	sulfurtransferase activity
A8B88_RS17030	COG0730	response to heat
A8B88_RS17035	COG0625	glutathione transferase activity
A8B88_RS17040	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A8B88_RS17045	COG3909	cytochrome
A8B88_RS17085	COG0154	amidase activity
A8B88_RS17090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B88_RS17095	COG1024	Enoyl-CoA hydratase
A8B88_RS17110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8B88_RS17125	COG1028	Short-chain dehydrogenase reductase Sdr
A8B88_RS17130	COG1414	Transcriptional regulator
A8B88_RS17140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A8B88_RS17145	COG0251	oxidation-reduction process
A8B88_RS17150	COG0559	Belongs to the binding-protein-dependent transport system permease family
A8B88_RS17170	COG1902	pentaerythritol trinitrate reductase activity
A8B88_RS17185	COG0583	DNA-binding transcription factor activity
A8B88_RS17195	COG0590	tRNA wobble adenosine to inosine editing
A8B88_RS17200	COG2807	transmembrane transport
A8B88_RS17220	COG0154	amidase activity
A8B88_RS17225	COG0307	riboflavin synthase, alpha
A8B88_RS17230	COG3181	Tripartite tricarboxylate transporter family receptor
A8B88_RS17235	COG1522	sequence-specific DNA binding
A8B88_RS17245	COG0318	PFAM AMP-dependent synthetase and ligase
A8B88_RS17255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8B88_RS17275	COG1063	alcohol dehydrogenase
A8B88_RS17300	COG1418	mRNA catabolic process
A8B88_RS17305	COG1448	Aminotransferase
A8B88_RS17310	COG0583	DNA-binding transcription factor activity
A8B88_RS17320	COG0477	Major facilitator Superfamily
A8B88_RS17325	COG1028	Short-chain dehydrogenase reductase Sdr
A8B88_RS17340	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A8B88_RS17345	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A8B88_RS17350	COG0583	DNA-binding transcription factor activity
A8B88_RS17390	COG1028	Short-chain dehydrogenase reductase Sdr
A8B88_RS17395	COG1309	transcriptional regulator
A8B88_RS17405	COG2982	Protein involved in outer membrane biogenesis
A8B88_RS17410	COG2818	Glycosylase
A8B88_RS17430	COG1653	transport
A8B88_RS17440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A8B88_RS17445	COG3842	ATPase activity
A8B88_RS17450	COG0395	ABC-type sugar transport system, permease component
A8B88_RS17455	COG1175	transmembrane transport
A8B88_RS17480	COG3181	Tripartite tricarboxylate transporter family receptor
A8B88_RS17485	COG2186	Transcriptional regulator
A8B88_RS17510	COG1454	alcohol dehydrogenase
A8B88_RS17530	COG2011	ABC-type metal ion transport system permease component
A8B88_RS17535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A8B88_RS17540	COG1501	Belongs to the glycosyl hydrolase 31 family
A8B88_RS17560	COG0318	PFAM AMP-dependent synthetase and ligase
A8B88_RS17565	COG1473	amidohydrolase
A8B88_RS17575	COG2855	membrane
A8B88_RS17585	COG2239	Acts as a magnesium transporter
A8B88_RS17605	COG3181	Tripartite tricarboxylate transporter family receptor
A8B88_RS17615	COG1722	exodeoxyribonuclease VII activity
A8B88_RS17620	COG0142	geranyltranstransferase activity
A8B88_RS17625	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A8B88_RS17630	COG1469	GTP cyclohydrolase I activity
A8B88_RS17635	COG0360	Binds together with S18 to 16S ribosomal RNA
A8B88_RS17640	COG2965	DNA replication, synthesis of RNA primer
A8B88_RS17645	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A8B88_RS17650	COG0359	binds to the 23S rRNA
A8B88_RS17660	COG0305	Participates in initiation and elongation during chromosome replication
A8B88_RS17670	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A8B88_RS17675	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A8B88_RS17680	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A8B88_RS17685	COG3737	Protein of unknown function (DUF498/DUF598)
A8B88_RS17690	COG0436	Aminotransferase
A8B88_RS17715	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A8B88_RS17745	COG0268	Binds directly to 16S ribosomal RNA
A8B88_RS17755	COG0728	peptidoglycan biosynthetic process
A8B88_RS17765	COG0563	adenylate kinase activity
A8B88_RS17770	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A8B88_RS17775	COG2835	tetraacyldisaccharide 4'-kinase activity
A8B88_RS17780	COG1663	tetraacyldisaccharide 4'-kinase activity
A8B88_RS17785	COG0848	biopolymer transport protein
A8B88_RS17790	COG0811	peptide transport
A8B88_RS17800	COG1570	exodeoxyribonuclease VII activity
A8B88_RS17815	COG0183	Belongs to the thiolase family
A8B88_RS17825	COG1278	Cold shock
A8B88_RS17830	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A8B88_RS17840	COG4953	penicillin-binding protein 1C
A8B88_RS17845	COG0542	response to heat
A8B88_RS17850	COG2995	paraquat-inducible protein a
A8B88_RS17865	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A8B88_RS17865	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A8B88_RS17865	COG0506	proline dehydrogenase activity
A8B88_RS17900	COG2271	Major facilitator Superfamily
A8B88_RS17905	COG1309	transcriptional regulator
A8B88_RS17915	COG3468	outer membrane autotransporter barrel domain protein
A8B88_RS17945	COG0477	Major facilitator Superfamily
A8B88_RS17955	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A8B88_RS17960	COG1845	cytochrome c oxidase, subunit III
A8B88_RS17965	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A8B88_RS17975	COG1028	Short-chain dehydrogenase reductase Sdr
A8B88_RS17995	COG0789	Transcriptional regulator
A8B88_RS18020	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A8B88_RS18025	COG0697	spore germination
A8B88_RS18035	COG0678	peroxiredoxin activity
A8B88_RS18045	COG0412	Dienelactone hydrolase
A8B88_RS18055	COG0315	cyclic pyranopterin monophosphate synthase activity
A8B88_RS18070	COG0521	Mo-molybdopterin cofactor biosynthetic process
A8B88_RS18075	COG0303	'Molybdopterin
A8B88_RS18080	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A8B88_RS18100	COG0165	Argininosuccinate lyase
A8B88_RS18105	COG0668	transmembrane transport
A8B88_RS18150	COG0747	negative chemotaxis
A8B88_RS18155	COG0601	transmembrane transport
A8B88_RS18160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8B88_RS18165	COG1162	GTPase activity
A8B88_RS18170	COG0501	Belongs to the peptidase M48B family
A8B88_RS18175	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A8B88_RS18185	COG3327	negative regulation of DNA-templated transcription, initiation
A8B88_RS18190	COG3396	Phenylacetate-CoA oxygenase
A8B88_RS18195	COG3460	Phenylacetate-CoA oxygenase
A8B88_RS18200	COG3396	Phenylacetate-CoA oxygenase
A8B88_RS18205	COG2151	metal-sulfur cluster biosynthetic enzyme
A8B88_RS18210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A8B88_RS18220	COG1012	belongs to the aldehyde dehydrogenase family
A8B88_RS18225	COG1024	Enoyl-CoA hydratase
A8B88_RS18230	COG2050	protein possibly involved in aromatic compounds catabolism
A8B88_RS18240	COG3539	Fimbrial protein
A8B88_RS18255	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8B88_RS18260	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A8B88_RS18260	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8B88_RS18265	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A8B88_RS18275	COG3064	Membrane
A8B88_RS18275	COG3210	domain, Protein
A8B88_RS18275	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
A8B88_RS18300	COG0235	Class ii aldolase
A8B88_RS18305	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A8B88_RS18310	COG0720	synthase
A8B88_RS18315	COG0602	queuosine metabolic process
A8B88_RS18340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8B88_RS18375	COG3181	Tripartite tricarboxylate transporter family receptor
A8B88_RS18405	COG3842	ATPase activity
A8B88_RS18415	COG0395	ABC-type sugar transport system, permease component
A8B88_RS18445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8B88_RS18450	COG0420	3'-5' exonuclease activity
A8B88_RS18475	COG2197	response regulator
A8B88_RS18500	COG0519	Catalyzes the synthesis of GMP from XMP
A8B88_RS18500	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A8B88_RS18510	COG3550	peptidyl-serine autophosphorylation
A8B88_RS18520	COG0477	Major facilitator Superfamily
A8B88_RS18535	COG1228	amidohydrolase
A8B88_RS18545	COG1116	anion transmembrane transporter activity
A8B88_RS18550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8B88_RS18585	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A8B88_RS18600	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A8B88_RS18630	COG2814	Major facilitator Superfamily
A8B88_RS18645	COG1280	lysine exporter protein (LysE YggA)
A8B88_RS18660	COG0747	negative chemotaxis
A8B88_RS18665	COG0601	transmembrane transport
A8B88_RS18670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8B88_RS18675	COG4172	Belongs to the ABC transporter superfamily
A8B88_RS18680	COG1609	Transcriptional regulator
A8B88_RS18705	COG0586	Pfam SNARE associated Golgi protein
A8B88_RS18715	COG0500	methyltransferase
A8B88_RS18730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8B88_RS18740	COG0756	dUTP diphosphatase activity
A8B88_RS18750	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A8B88_RS18755	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A8B88_RS18760	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A8B88_RS18765	COG0072	phenylalanine-tRNA ligase activity
A8B88_RS18765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8B88_RS18770	COG0776	regulation of translation
A8B88_RS18840	COG0540	Belongs to the ATCase OTCase family
A8B88_RS18845	COG2974	May be involved in recombination
A8B88_RS18855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B88_RS18860	COG0583	DNA-binding transcription factor activity
A8B88_RS18880	COG1028	Short-chain dehydrogenase reductase Sdr
A8B88_RS18895	COG3842	ATPase activity
A8B88_RS18900	COG1024	Enoyl-CoA hydratase
A8B88_RS18900	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8B88_RS18920	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A8B88_RS18925	COG2137	regulation of response to DNA damage stimulus
A8B88_RS18935	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A8B88_RS18945	COG0045	succinate-CoA ligase (ADP-forming) activity
A8B88_RS18950	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A8B88_RS18955	COG0861	Integral membrane protein TerC family
A8B88_RS18960	COG0861	Integral membrane protein TerC family
A8B88_RS18965	COG0181	hydroxymethylbilane synthase activity
A8B88_RS19025	COG4964	Belongs to the GSP D family
A8B88_RS19055	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A8B88_RS19065	COG0583	DNA-binding transcription factor activity
A8B88_RS19075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8B88_RS19080	COG4311	Sarcosine oxidase, delta subunit
A8B88_RS19085	COG0446	pyridine nucleotide-disulphide oxidoreductase
A8B88_RS19085	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A8B88_RS19120	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A8B88_RS19125	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A8B88_RS19130	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A8B88_RS19135	COG0735	belongs to the Fur family
A8B88_RS19140	COG0497	DNA recombination
A8B88_RS19145	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A8B88_RS19150	COG1420	regulation of RNA biosynthetic process
A8B88_RS19155	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A8B88_RS19165	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A8B88_RS19185	COG0612	Peptidase, M16
A8B88_RS19205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A8B88_RS19255	COG0745	RESPONSE REGULATOR receiver
A8B88_RS19260	COG2205	protein histidine kinase activity
A8B88_RS19265	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A8B88_RS19270	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A8B88_RS19275	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A8B88_RS19290	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A8B88_RS19305	COG1193	negative regulation of DNA recombination
A8B88_RS19310	COG0492	ferredoxin-NADP+ reductase activity
A8B88_RS19315	COG1674	ftsk spoiiie
A8B88_RS19320	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A8B88_RS19325	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A8B88_RS19330	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A8B88_RS19355	COG3706	GGDEF domain
A8B88_RS19375	COG2814	Major facilitator Superfamily
A8B88_RS19405	COG3486	L-lysine 6-monooxygenase (NADPH) activity
A8B88_RS19420	COG1028	Short-chain dehydrogenase reductase Sdr
A8B88_RS19430	COG3022	response to hydroperoxide
A8B88_RS19440	COG1289	transmembrane transporter activity
A8B88_RS19445	COG3023	N-Acetylmuramoyl-L-alanine amidase
A8B88_RS19455	COG0424	maF-like protein
A8B88_RS19460	COG1399	metal-binding, possibly nucleic acid-binding protein
A8B88_RS19465	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A8B88_RS19470	COG0416	fatty acid biosynthetic process
A8B88_RS19475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A8B88_RS19490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8B88_RS19495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A8B88_RS19520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8B88_RS19525	COG0481	GTPase activity
A8B88_RS19530	COG0681	Belongs to the peptidase S26 family
A8B88_RS19535	COG0571	ribonuclease III activity
A8B88_RS19540	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A8B88_RS19545	COG1381	Involved in DNA repair and RecF pathway recombination
A8B88_RS19555	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A8B88_RS19570	COG3181	Tripartite tricarboxylate transporter family receptor
A8B88_RS19575	COG0670	Belongs to the BI1 family
A8B88_RS19590	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A8B88_RS19600	COG0583	DNA-binding transcription factor activity
A8B88_RS19615	COG0583	DNA-binding transcription factor activity
A8B88_RS19630	COG0791	NLP P60 protein
A8B88_RS19635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A8B88_RS19640	COG3193	protein, possibly involved in utilization of glycolate and propanediol
A8B88_RS19650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A8B88_RS19655	COG0697	spore germination
A8B88_RS19660	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
A8B88_RS19675	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family