locus-tag	class	description
A8B94_RS00005	COG0445	tRNA wobble uridine modification
A8B94_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
A8B94_RS00015	COG1192	Involved in chromosome partitioning
A8B94_RS00025	COG1475	DNA binding
A8B94_RS00030	COG0252	asparaginase activity
A8B94_RS00055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A8B94_RS00065	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A8B94_RS00075	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A8B94_RS00080	COG0081	regulation of translation
A8B94_RS00085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A8B94_RS00090	COG0222	ribosome binding
A8B94_RS00095	COG0085	RNA polymerase activity
A8B94_RS00100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A8B94_RS00140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B94_RS00165	COG1024	Enoyl-CoA hydratase
A8B94_RS00185	COG0752	glycyl-tRNA synthetase alpha subunit
A8B94_RS00190	COG0751	glycine-tRNA ligase activity
A8B94_RS00195	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A8B94_RS00200	COG0204	Acyl-transferase
A8B94_RS00215	COG0242	peptide deformylase activity
A8B94_RS00250	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A8B94_RS00255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A8B94_RS00260	COG2813	Specifically methylates the guanine in position
A8B94_RS00260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A8B94_RS00270	COG2223	nitrite transmembrane transporter activity
A8B94_RS00280	COG1794	racemase activity, acting on amino acids and derivatives
A8B94_RS00285	COG1126	abc transporter atp-binding protein
A8B94_RS00290	COG0765	amino acid transport
A8B94_RS00295	COG0765	amino acid transport
A8B94_RS00300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8B94_RS00360	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8B94_RS00390	COG0326	Molecular chaperone. Has ATPase activity
A8B94_RS00395	COG0625	glutathione transferase activity
A8B94_RS00410	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A8B94_RS00415	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A8B94_RS00445	COG0438	transferase activity, transferring glycosyl groups
A8B94_RS00450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A8B94_RS00455	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A8B94_RS00485	COG0859	PFAM glycosyl transferase family 9
A8B94_RS00500	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A8B94_RS00510	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A8B94_RS00515	COG1127	ABC transporter
A8B94_RS00540	COG1686	Belongs to the peptidase S11 family
A8B94_RS00550	COG2921	Belongs to the UPF0250 family
A8B94_RS00555	COG0321	lipoyl(octanoyl) transferase activity
A8B94_RS00560	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A8B94_RS00595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A8B94_RS00605	COG0018	arginyl-trna synthetase
A8B94_RS00625	COG0395	ABC-type sugar transport system, permease component
A8B94_RS00630	COG1175	transmembrane transport
A8B94_RS00635	COG1653	transport
A8B94_RS00640	COG3842	ATPase activity
A8B94_RS00645	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A8B94_RS00655	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A8B94_RS00675	COG1609	Transcriptional regulator
A8B94_RS00685	COG0154	amidase activity
A8B94_RS00690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A8B94_RS00700	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A8B94_RS00710	COG0583	DNA-binding transcription factor activity
A8B94_RS00725	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A8B94_RS00730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A8B94_RS00745	COG1802	Transcriptional regulator
A8B94_RS00760	COG1024	Enoyl-CoA hydratase
A8B94_RS00775	COG3181	Tripartite tricarboxylate transporter family receptor
A8B94_RS00790	COG1984	allophanate hydrolase subunit 2
A8B94_RS00795	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A8B94_RS00805	COG0583	DNA-binding transcription factor activity
A8B94_RS00810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8B94_RS00820	COG5002	protein histidine kinase activity
A8B94_RS00830	COG5002	protein histidine kinase activity
A8B94_RS00835	COG0745	RESPONSE REGULATOR receiver
A8B94_RS00840	COG2226	methyltransferase
A8B94_RS00855	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A8B94_RS00875	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A8B94_RS00885	COG0513	Belongs to the DEAD box helicase family
A8B94_RS00890	COG1280	lysine exporter protein (LysE YggA)
A8B94_RS00895	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A8B94_RS00930	COG1054	Belongs to the UPF0176 family
A8B94_RS00935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8B94_RS00935	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8B94_RS00945	COG0489	protein tyrosine kinase activity
A8B94_RS00960	COG0717	Belongs to the dCTP deaminase family
A8B94_RS00990	COG2081	HI0933 family
A8B94_RS01000	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A8B94_RS01010	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A8B94_RS01015	COG0509	glycine decarboxylation via glycine cleavage system
A8B94_RS01020	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A8B94_RS01020	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A8B94_RS01060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A8B94_RS01075	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A8B94_RS01085	COG1414	Transcriptional regulator
A8B94_RS01090	COG1028	Short-chain dehydrogenase reductase Sdr
A8B94_RS01095	COG2031	fatty acid transporter
A8B94_RS01100	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8B94_RS01110	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A8B94_RS01115	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A8B94_RS01125	COG4257	antibiotic catabolic process
A8B94_RS01145	COG1012	belongs to the aldehyde dehydrogenase family
A8B94_RS01150	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A8B94_RS01155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A8B94_RS01180	COG1028	Short-chain dehydrogenase reductase Sdr
A8B94_RS01190	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A8B94_RS01200	COG2188	Transcriptional regulator
A8B94_RS01205	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A8B94_RS01230	COG0617	tRNA 3'-terminal CCA addition
A8B94_RS01245	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A8B94_RS01250	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A8B94_RS01255	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A8B94_RS01260	COG0586	Pfam SNARE associated Golgi protein
A8B94_RS01265	COG0860	N-Acetylmuramoyl-L-alanine amidase
A8B94_RS01270	COG0802	atpase or kinase
A8B94_RS01275	COG0114	fumarate hydratase activity
A8B94_RS01285	COG3181	Tripartite tricarboxylate transporter family receptor
A8B94_RS01295	COG0405	Gamma-glutamyltransferase
A8B94_RS01300	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B94_RS01310	COG1960	acyl-CoA dehydrogenase activity
A8B94_RS01335	COG1294	oxidase, subunit
A8B94_RS01345	COG4988	ABC transporter
A8B94_RS01350	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A8B94_RS01355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A8B94_RS01370	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A8B94_RS01395	COG2969	positive regulation of protein catabolic process
A8B94_RS01400	COG0625	glutathione transferase activity
A8B94_RS01405	COG2857	Cytochrome c1
A8B94_RS01410	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A8B94_RS01415	COG0723	plastoquinol--plastocyanin reductase activity
A8B94_RS01420	COG1970	mechanosensitive ion channel activity
A8B94_RS01425	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A8B94_RS01440	COG2808	Putative FMN-binding domain
A8B94_RS01445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8B94_RS01450	COG0747	negative chemotaxis
A8B94_RS01455	COG0657	acetylesterase activity
A8B94_RS01465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A8B94_RS01470	COG2207	Transcriptional regulator
A8B94_RS01475	COG0129	dihydroxy-acid dehydratase activity
A8B94_RS01480	COG2814	Major facilitator Superfamily
A8B94_RS01485	COG0583	DNA-binding transcription factor activity
A8B94_RS01495	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
A8B94_RS01565	COG1024	Enoyl-CoA hydratase
A8B94_RS01570	COG1960	acyl-CoA dehydrogenase activity
A8B94_RS01595	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A8B94_RS01600	COG0352	thiamine-phosphate diphosphorylase activity
A8B94_RS01615	COG1678	Uncharacterized ACR, COG1678
A8B94_RS01620	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A8B94_RS01625	COG0540	Belongs to the ATCase OTCase family
A8B94_RS01640	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A8B94_RS01650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A8B94_RS01685	COG1234	tRNA 3'-trailer cleavage
A8B94_RS01730	COG1683	Conserved Protein
A8B94_RS01735	COG1120	ATPase activity
A8B94_RS01740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8B94_RS01745	COG4558	Periplasmic binding protein
A8B94_RS01750	COG3720	iron ion transport
A8B94_RS01760	COG3712	iron ion homeostasis
A8B94_RS01765	COG1595	DNA-templated transcription, initiation
A8B94_RS01800	COG1802	Transcriptional regulator
A8B94_RS01810	COG3069	C4-dicarboxylate transmembrane transporter activity
A8B94_RS01820	COG1012	belongs to the aldehyde dehydrogenase family
A8B94_RS01855	COG2860	membrane
A8B94_RS01860	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A8B94_RS01865	COG0708	Exodeoxyribonuclease III
A8B94_RS01870	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A8B94_RS01875	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A8B94_RS01880	COG0154	amidase activity
A8B94_RS01885	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A8B94_RS01890	COG1077	Cell shape determining protein MreB Mrl
A8B94_RS01895	COG1792	Involved in formation and maintenance of cell shape
A8B94_RS01905	COG0768	penicillin binding
A8B94_RS01910	COG0772	Belongs to the SEDS family
A8B94_RS01915	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A8B94_RS01920	COG0471	metal ion transport
A8B94_RS01925	COG1309	transcriptional regulator
A8B94_RS01935	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A8B94_RS01950	COG2823	Periplasmic or secreted lipoprotein
A8B94_RS01955	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A8B94_RS01970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A8B94_RS01990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B94_RS02000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B94_RS02025	COG0492	ferredoxin-NADP+ reductase activity
A8B94_RS02035	COG3181	Tripartite tricarboxylate transporter family receptor
A8B94_RS02040	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8B94_RS02040	COG1024	Enoyl-CoA hydratase
A8B94_RS02045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B94_RS02050	COG0028	Belongs to the TPP enzyme family
A8B94_RS02075	COG3181	Tripartite tricarboxylate transporter family receptor
A8B94_RS02085	COG0697	spore germination
A8B94_RS02110	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A8B94_RS02115	COG0463	Glycosyl transferase, family 2
A8B94_RS02130	COG0786	glutamate:sodium symporter activity
A8B94_RS02140	COG2031	fatty acid transporter
A8B94_RS02155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A8B94_RS02160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A8B94_RS02170	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A8B94_RS02185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8B94_RS02195	COG1285	pathogenesis
A8B94_RS02200	COG1253	flavin adenine dinucleotide binding
A8B94_RS02205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B94_RS02210	COG1024	Enoyl-CoA hydratase
A8B94_RS02215	COG3181	Tripartite tricarboxylate transporter family receptor
A8B94_RS02220	COG0583	DNA-binding transcription factor activity
A8B94_RS02225	COG1960	acyl-CoA dehydrogenase activity
A8B94_RS02235	COG0183	Belongs to the thiolase family
A8B94_RS02255	COG0583	DNA-binding transcription factor activity
A8B94_RS02260	COG1278	Cold shock
A8B94_RS02270	COG1802	Transcriptional regulator
A8B94_RS02275	COG1012	belongs to the aldehyde dehydrogenase family
A8B94_RS02280	COG2031	fatty acid transporter
A8B94_RS02285	COG1017	nitric oxide dioxygenase activity
A8B94_RS02285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A8B94_RS02290	COG0251	oxidation-reduction process
A8B94_RS02315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B94_RS02325	COG0583	DNA-binding transcription factor activity
A8B94_RS02330	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B94_RS02340	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
A8B94_RS02345	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A8B94_RS02350	COG0546	phosphoglycolate phosphatase activity
A8B94_RS02360	COG1530	ribonuclease E activity
A8B94_RS02375	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A8B94_RS02380	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A8B94_RS02385	COG0159	tryptophan synthase activity
A8B94_RS02390	COG0133	tryptophan synthase activity
A8B94_RS02400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A8B94_RS02405	COG3228	Belongs to the MtfA family
A8B94_RS02415	COG0251	oxidation-reduction process
A8B94_RS02420	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A8B94_RS02425	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A8B94_RS02440	COG2878	Part of a membrane complex involved in electron transport
A8B94_RS02445	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A8B94_RS02480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A8B94_RS02500	COG1268	BioY protein
A8B94_RS02505	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A8B94_RS02510	COG1122	ATPase activity
A8B94_RS02515	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A8B94_RS02530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A8B94_RS02535	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A8B94_RS02545	COG1196	nuclear chromosome segregation
A8B94_RS02550	COG0477	Major facilitator Superfamily
A8B94_RS02555	COG1573	uracil-dna glycosylase
A8B94_RS02560	COG1214	PFAM Peptidase M22, glycoprotease
A8B94_RS02580	COG0450	alkyl hydroperoxide reductase
A8B94_RS02585	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A8B94_RS02595	COG2223	nitrite transmembrane transporter activity
A8B94_RS02605	COG2186	Transcriptional regulator
A8B94_RS02625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8B94_RS02635	COG0583	DNA-binding transcription factor activity
A8B94_RS02645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A8B94_RS02650	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A8B94_RS02655	COG0137	argininosuccinate synthase activity
A8B94_RS02660	COG3158	transport of potassium into the cell
A8B94_RS02665	COG0642	Histidine kinase
A8B94_RS02695	COG0776	regulation of translation
A8B94_RS02700	COG3128	pkhd-type hydroxylase
A8B94_RS02710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A8B94_RS02715	COG0557	exoribonuclease II activity
A8B94_RS02740	COG0679	Auxin Efflux Carrier
A8B94_RS02745	COG2391	methyltransferase activity
A8B94_RS02750	COG0069	glutamate synthase activity
A8B94_RS02760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A8B94_RS02770	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
A8B94_RS02775	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A8B94_RS02810	COG3706	GGDEF domain
A8B94_RS02825	COG1053	succinate dehydrogenase
A8B94_RS02830	COG0583	DNA-binding transcription factor activity
A8B94_RS02840	COG1053	succinate dehydrogenase
A8B94_RS02860	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A8B94_RS02865	COG0459	protein refolding
A8B94_RS02870	COG3468	outer membrane autotransporter barrel domain protein
A8B94_RS02885	COG1252	NADH dehydrogenase
A8B94_RS02890	COG0284	orotidine-5'-phosphate decarboxylase activity
A8B94_RS02895	COG1546	Belongs to the CinA family
A8B94_RS02895	COG1058	Belongs to the CinA family
A8B94_RS02900	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A8B94_RS02910	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A8B94_RS02915	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A8B94_RS02950	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A8B94_RS02955	COG3639	organic phosphonate transmembrane transporter activity
A8B94_RS02960	COG3639	organic phosphonate transmembrane transporter activity
A8B94_RS02980	COG0742	ribosomal rna small subunit methyltransferase
A8B94_RS02985	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A8B94_RS02990	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A8B94_RS02995	COG3135	benzoate transporter
A8B94_RS03010	COG0640	Transcriptional regulator
A8B94_RS03040	COG4172	Belongs to the ABC transporter superfamily
A8B94_RS03045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8B94_RS03050	COG0601	transmembrane transport
A8B94_RS03060	COG0280	phosphate acetyltransferase
A8B94_RS03060	COG0281	malic enzyme
A8B94_RS03120	COG0583	DNA-binding transcription factor activity
A8B94_RS03130	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A8B94_RS03135	COG0167	dihydroorotate dehydrogenase activity
A8B94_RS03155	COG1414	Transcriptional regulator
A8B94_RS03160	COG1058	Belongs to the CinA family
A8B94_RS03160	COG1546	Belongs to the CinA family
A8B94_RS03180	COG0513	Belongs to the DEAD box helicase family
A8B94_RS03210	COG0429	hydrolase of the alpha beta-hydrolase fold
A8B94_RS03215	COG4783	chaperone-mediated protein folding
A8B94_RS03230	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A8B94_RS03255	COG0006	proline dipeptidase activity
A8B94_RS03265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A8B94_RS03285	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A8B94_RS03290	COG0632	four-way junction helicase activity
A8B94_RS03305	COG2255	four-way junction helicase activity
A8B94_RS03310	COG0514	ATP-dependent DNA helicase (RecQ)
A8B94_RS03325	COG0288	reversible hydration of carbon dioxide
A8B94_RS03330	COG0154	amidase activity
A8B94_RS03340	COG4211	Belongs to the binding-protein-dependent transport system permease family
A8B94_RS03370	COG1464	Belongs to the NlpA lipoprotein family
A8B94_RS03510	COG1196	nuclear chromosome segregation
A8B94_RS03575	COG2135	peptidase activity
A8B94_RS03590	COG0494	nUDIX hydrolase
A8B94_RS03595	COG0442	prolyl-tRNA aminoacylation
A8B94_RS03600	COG0824	Thioesterase
A8B94_RS03605	COG0811	peptide transport
A8B94_RS03610	COG0848	biopolymer transport protein
A8B94_RS03620	COG0823	Involved in the tonB-independent uptake of proteins
A8B94_RS03635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8B94_RS03640	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A8B94_RS03670	COG0700	Nucleoside recognition
A8B94_RS03675	COG0469	pyruvate kinase activity
A8B94_RS03680	COG1929	Belongs to the glycerate kinase type-1 family
A8B94_RS03685	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A8B94_RS03690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A8B94_RS03695	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A8B94_RS03705	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A8B94_RS03715	COG2154	pterin-4-alpha-carbinolamine dehydratase
A8B94_RS03740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A8B94_RS03745	COG0154	amidase activity
A8B94_RS03755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8B94_RS03760	COG0601	transmembrane transport
A8B94_RS03765	COG0747	negative chemotaxis
A8B94_RS03785	COG0019	diaminopimelate decarboxylase activity
A8B94_RS03810	COG2353	YceI-like domain
A8B94_RS03815	COG4774	siderophore transport
A8B94_RS03820	COG3712	iron ion homeostasis
A8B94_RS03860	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A8B94_RS03865	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A8B94_RS03870	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A8B94_RS03875	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A8B94_RS03885	COG0142	geranyltranstransferase activity
A8B94_RS03895	COG0583	DNA-binding transcription factor activity
A8B94_RS03905	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
A8B94_RS03910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8B94_RS03925	COG2994	toxin metabolic process
A8B94_RS03935	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
A8B94_RS03940	COG2274	protein secretion by the type I secretion system
A8B94_RS03945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8B94_RS03950	COG1538	Outer membrane efflux protein
A8B94_RS03970	COG0765	amino acid transport
A8B94_RS03975	COG1126	abc transporter atp-binding protein
A8B94_RS03995	COG1028	Short-chain dehydrogenase reductase Sdr
A8B94_RS04005	COG1802	Transcriptional regulator
A8B94_RS04015	COG1802	Transcriptional regulator
A8B94_RS04025	COG0318	PFAM AMP-dependent synthetase and ligase
A8B94_RS04035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8B94_RS04055	COG0028	Belongs to the TPP enzyme family
A8B94_RS04075	COG0308	aminopeptidase N
A8B94_RS04080	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A8B94_RS04090	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A8B94_RS04095	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A8B94_RS04100	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A8B94_RS04105	COG0560	Phosphoserine phosphatase
A8B94_RS04110	COG0583	DNA-binding transcription factor activity
A8B94_RS04115	COG3181	Tripartite tricarboxylate transporter family receptor
A8B94_RS04120	COG0028	Belongs to the TPP enzyme family
A8B94_RS04135	COG4774	siderophore transport
A8B94_RS04140	COG4774	siderophore transport
A8B94_RS04150	COG1007	ATP synthesis coupled electron transport
A8B94_RS04165	COG0713	ATP synthesis coupled electron transport
A8B94_RS04175	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8B94_RS04180	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A8B94_RS04185	COG1034	ATP synthesis coupled electron transport
A8B94_RS04195	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A8B94_RS04200	COG0649	NAD binding
A8B94_RS04205	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8B94_RS04210	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8B94_RS04215	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8B94_RS04220	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A8B94_RS04245	COG0671	phosphoesterase, PA-phosphatase related
A8B94_RS04255	COG1597	lipid kinase activity
A8B94_RS04260	COG0583	DNA-binding transcription factor activity
A8B94_RS04265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A8B94_RS04275	COG1733	regulation of RNA biosynthetic process
A8B94_RS04280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8B94_RS04285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A8B94_RS04300	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
A8B94_RS04320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8B94_RS04340	COG3608	succinylglutamate desuccinylase aspartoacylase
A8B94_RS04345	COG0626	cystathionine gamma-synthase activity
A8B94_RS04350	COG0583	DNA-binding transcription factor activity
A8B94_RS04390	COG3799	methylaspartate ammonia-lyase activity
A8B94_RS04400	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A8B94_RS04410	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A8B94_RS04415	COG0149	triose-phosphate isomerase activity
A8B94_RS04435	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A8B94_RS04450	COG1185	polyribonucleotide nucleotidyltransferase activity
A8B94_RS04455	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A8B94_RS04465	COG1183	phosphatidylcholine synthase activity
A8B94_RS04470	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A8B94_RS04475	COG0440	acetolactate synthase activity
A8B94_RS04480	COG0028	Belongs to the TPP enzyme family
A8B94_RS04495	COG5265	(ABC) transporter
A8B94_RS04500	COG0500	methyltransferase
A8B94_RS04515	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
A8B94_RS04535	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A8B94_RS04545	COG0511	ligase activity, forming carbon-carbon bonds
A8B94_RS04570	COG2188	Transcriptional regulator
A8B94_RS04575	COG0439	Biotin carboxylase
A8B94_RS04580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A8B94_RS04625	COG5265	(ABC) transporter
A8B94_RS04635	COG0667	Aldo Keto reductase
A8B94_RS04650	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A8B94_RS04685	COG0583	DNA-binding transcription factor activity
A8B94_RS04710	COG2814	Major facilitator Superfamily
A8B94_RS04720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A8B94_RS04735	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A8B94_RS04745	COG0287	Prephenate dehydrogenase
A8B94_RS04750	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A8B94_RS04755	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A8B94_RS04775	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A8B94_RS04780	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A8B94_RS04785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8B94_RS04790	COG1555	photosystem II stabilization
A8B94_RS04790	COG1596	polysaccharide export
A8B94_RS04805	COG2951	lytic endotransglycosylase activity
A8B94_RS04810	COG0123	including yeast histone deacetylase and acetoin utilization protein
A8B94_RS04825	COG1960	acyl-CoA dehydrogenase activity
A8B94_RS04830	COG0450	alkyl hydroperoxide reductase
A8B94_RS04845	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A8B94_RS04850	COG4208	sulfate ABC transporter
A8B94_RS04855	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A8B94_RS04860	COG0175	sulfate reduction
A8B94_RS04890	COG0335	large ribosomal subunit rRNA binding
A8B94_RS04905	COG0667	Aldo Keto reductase
A8B94_RS04915	COG2814	Major facilitator Superfamily
A8B94_RS04920	COG3161	chorismate lyase activity
A8B94_RS04925	COG1187	pseudouridine synthase activity
A8B94_RS04935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8B94_RS04955	COG1999	signal sequence binding
A8B94_RS04960	COG0339	signal peptide processing
A8B94_RS04965	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A8B94_RS04970	COG4566	intracellular signal transduction
A8B94_RS04980	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A8B94_RS04985	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8B94_RS04990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A8B94_RS04995	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A8B94_RS05005	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A8B94_RS05010	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A8B94_RS05015	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A8B94_RS05020	COG0126	phosphoglycerate kinase activity
A8B94_RS05025	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A8B94_RS05030	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A8B94_RS05045	COG0625	glutathione transferase activity
A8B94_RS05075	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A8B94_RS05085	COG0521	Mo-molybdopterin cofactor biosynthetic process
A8B94_RS05095	COG0739	heme binding
A8B94_RS05105	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A8B94_RS05140	COG0745	RESPONSE REGULATOR receiver
A8B94_RS05155	COG0840	transmembrane signaling receptor activity
A8B94_RS05165	COG2201	protein-glutamate methylesterase activity
A8B94_RS05170	COG0745	RESPONSE REGULATOR receiver
A8B94_RS05175	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
A8B94_RS05200	COG0667	Aldo Keto reductase
A8B94_RS05210	COG4535	Mg2 and Co2 transporter CorC
A8B94_RS05215	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A8B94_RS05220	COG1702	phosphate starvation-inducible protein PhoH
A8B94_RS05225	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A8B94_RS05240	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A8B94_RS05245	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A8B94_RS05250	COG1862	Preprotein translocase
A8B94_RS05255	COG0343	queuine tRNA-ribosyltransferase activity
A8B94_RS05260	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A8B94_RS05265	COG2027	D-alanyl-D-alanine carboxypeptidase
A8B94_RS05270	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A8B94_RS05280	COG3468	outer membrane autotransporter barrel domain protein
A8B94_RS05290	COG3468	outer membrane autotransporter barrel domain protein
A8B94_RS05295	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A8B94_RS05295	COG1648	precorrin-2 dehydrogenase activity
A8B94_RS05320	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A8B94_RS05325	COG0741	lytic transglycosylase activity
A8B94_RS05330	COG0436	Aminotransferase
A8B94_RS05340	COG0281	malic enzyme
A8B94_RS05340	COG0280	phosphate acetyltransferase
A8B94_RS05350	COG2732	(Barnase) inhibitor
A8B94_RS05365	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A8B94_RS05390	COG0248	Ppx GppA phosphatase
A8B94_RS05400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A8B94_RS05410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A8B94_RS05415	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A8B94_RS05420	COG1534	Rna-binding protein
A8B94_RS05445	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A8B94_RS05460	COG1295	ribonuclease BN
A8B94_RS05470	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A8B94_RS05475	COG0745	RESPONSE REGULATOR receiver
A8B94_RS05480	COG2205	protein histidine kinase activity
A8B94_RS05515	COG1022	Amp-dependent synthetase and ligase
A8B94_RS05530	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A8B94_RS05535	COG1028	Short-chain dehydrogenase reductase Sdr
A8B94_RS05540	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A8B94_RS05545	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A8B94_RS05560	COG1136	(ABC) transporter
A8B94_RS05565	COG0084	hydrolase, TatD family'
A8B94_RS05600	COG0613	PHP domain protein
A8B94_RS05615	COG3539	Fimbrial protein
A8B94_RS05620	COG0281	malic enzyme
A8B94_RS05620	COG0280	phosphate acetyltransferase
A8B94_RS05630	COG1522	sequence-specific DNA binding
A8B94_RS05635	COG1297	OPT oligopeptide transporter protein
A8B94_RS05640	COG1297	OPT oligopeptide transporter protein
A8B94_RS05645	COG0567	Dehydrogenase, E1 component
A8B94_RS05650	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8B94_RS05655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A8B94_RS05660	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A8B94_RS05665	COG1028	Short-chain dehydrogenase reductase Sdr
A8B94_RS05670	COG0583	DNA-binding transcription factor activity
A8B94_RS05680	COG3181	Tripartite tricarboxylate transporter family receptor
A8B94_RS05700	COG0180	Tryptophanyl-tRNA synthetase
A8B94_RS05705	COG2183	response to ionizing radiation
A8B94_RS05710	COG1199	ATP-dependent helicase activity
A8B94_RS05720	COG0564	pseudouridine synthase activity
A8B94_RS05730	COG3243	poly(R)-hydroxyalkanoic acid synthase
A8B94_RS05735	COG1028	Short-chain dehydrogenase reductase Sdr
A8B94_RS05740	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
A8B94_RS05755	COG0672	)-iron permease
A8B94_RS05795	COG0583	DNA-binding transcription factor activity
A8B94_RS05805	COG2814	Major facilitator Superfamily
A8B94_RS05820	COG1619	proteins homologs of microcin C7 resistance protein MccF
A8B94_RS05835	COG2084	Dehydrogenase
A8B94_RS05840	COG3181	Tripartite tricarboxylate transporter family receptor
A8B94_RS05865	COG2988	succinylglutamate desuccinylase activity
A8B94_RS05885	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8B94_RS05890	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8B94_RS05890	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A8B94_RS05895	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A8B94_RS05900	COG0047	phosphoribosylformylglycinamidine synthase activity
A8B94_RS05900	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A8B94_RS05905	COG3210	domain, Protein
A8B94_RS05905	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
A8B94_RS05905	COG3064	Membrane
A8B94_RS05930	COG0235	Class ii aldolase
A8B94_RS05935	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A8B94_RS05940	COG0720	synthase
A8B94_RS05945	COG0602	queuosine metabolic process
A8B94_RS05970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8B94_RS06005	COG3181	Tripartite tricarboxylate transporter family receptor
A8B94_RS06035	COG3842	ATPase activity
A8B94_RS06045	COG0395	ABC-type sugar transport system, permease component
A8B94_RS06075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8B94_RS06080	COG0420	3'-5' exonuclease activity
A8B94_RS06105	COG2197	response regulator
A8B94_RS06130	COG0519	Catalyzes the synthesis of GMP from XMP
A8B94_RS06130	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A8B94_RS06140	COG3550	peptidyl-serine autophosphorylation
A8B94_RS06150	COG0477	Major facilitator Superfamily
A8B94_RS06165	COG1228	amidohydrolase
A8B94_RS06175	COG1116	anion transmembrane transporter activity
A8B94_RS06180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8B94_RS06215	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A8B94_RS06230	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A8B94_RS06260	COG2814	Major facilitator Superfamily
A8B94_RS06275	COG1280	lysine exporter protein (LysE YggA)
A8B94_RS06290	COG0747	negative chemotaxis
A8B94_RS06295	COG0601	transmembrane transport
A8B94_RS06300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8B94_RS06305	COG4172	Belongs to the ABC transporter superfamily
A8B94_RS06310	COG1609	Transcriptional regulator
A8B94_RS06335	COG0586	Pfam SNARE associated Golgi protein
A8B94_RS06345	COG0500	methyltransferase
A8B94_RS06360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8B94_RS06370	COG0756	dUTP diphosphatase activity
A8B94_RS06380	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A8B94_RS06385	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A8B94_RS06390	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A8B94_RS06395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8B94_RS06395	COG0072	phenylalanine-tRNA ligase activity
A8B94_RS06400	COG0776	regulation of translation
A8B94_RS06470	COG0540	Belongs to the ATCase OTCase family
A8B94_RS06475	COG2974	May be involved in recombination
A8B94_RS06485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B94_RS06490	COG0583	DNA-binding transcription factor activity
A8B94_RS06510	COG1028	Short-chain dehydrogenase reductase Sdr
A8B94_RS06525	COG3842	ATPase activity
A8B94_RS06530	COG1024	Enoyl-CoA hydratase
A8B94_RS06530	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8B94_RS06550	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A8B94_RS06555	COG2137	regulation of response to DNA damage stimulus
A8B94_RS06565	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A8B94_RS06575	COG0045	succinate-CoA ligase (ADP-forming) activity
A8B94_RS06580	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A8B94_RS06585	COG0861	Integral membrane protein TerC family
A8B94_RS06590	COG0861	Integral membrane protein TerC family
A8B94_RS06595	COG0181	hydroxymethylbilane synthase activity
A8B94_RS06655	COG4964	Belongs to the GSP D family
A8B94_RS06685	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A8B94_RS06695	COG0583	DNA-binding transcription factor activity
A8B94_RS06705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8B94_RS06710	COG4311	Sarcosine oxidase, delta subunit
A8B94_RS06715	COG0446	pyridine nucleotide-disulphide oxidoreductase
A8B94_RS06715	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A8B94_RS06750	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A8B94_RS06755	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A8B94_RS06760	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A8B94_RS06765	COG0735	belongs to the Fur family
A8B94_RS06770	COG0497	DNA recombination
A8B94_RS06775	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A8B94_RS06780	COG1420	regulation of RNA biosynthetic process
A8B94_RS06785	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A8B94_RS06795	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A8B94_RS06805	COG0443	Heat shock 70 kDa protein
A8B94_RS06815	COG0612	Peptidase, M16
A8B94_RS06835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A8B94_RS06880	COG0745	RESPONSE REGULATOR receiver
A8B94_RS06885	COG2205	protein histidine kinase activity
A8B94_RS06890	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A8B94_RS06895	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A8B94_RS06900	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A8B94_RS06915	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A8B94_RS06935	COG1193	negative regulation of DNA recombination
A8B94_RS06940	COG0492	ferredoxin-NADP+ reductase activity
A8B94_RS06945	COG1674	ftsk spoiiie
A8B94_RS06950	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A8B94_RS06955	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A8B94_RS06960	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A8B94_RS06985	COG3706	GGDEF domain
A8B94_RS07005	COG2814	Major facilitator Superfamily
A8B94_RS07035	COG3486	L-lysine 6-monooxygenase (NADPH) activity
A8B94_RS07050	COG1028	Short-chain dehydrogenase reductase Sdr
A8B94_RS07060	COG3022	response to hydroperoxide
A8B94_RS07070	COG1289	transmembrane transporter activity
A8B94_RS07095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A8B94_RS07105	COG2197	response regulator
A8B94_RS07110	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A8B94_RS07115	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A8B94_RS07120	COG0189	ligase activity
A8B94_RS07130	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8B94_RS07135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A8B94_RS07145	COG2423	ornithine cyclodeaminase activity
A8B94_RS07155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8B94_RS07160	COG0765	amino acid transport
A8B94_RS07165	COG0765	amino acid transport
A8B94_RS07170	COG1126	abc transporter atp-binding protein
A8B94_RS07225	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A8B94_RS07235	COG2944	sequence-specific DNA binding
A8B94_RS07240	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A8B94_RS07245	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A8B94_RS07250	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A8B94_RS07255	COG0009	L-threonylcarbamoyladenylate synthase
A8B94_RS07260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8B94_RS07265	COG1414	Transcriptional regulator
A8B94_RS07280	COG0765	amino acid transport
A8B94_RS07285	COG1126	abc transporter atp-binding protein
A8B94_RS07290	COG0028	Belongs to the TPP enzyme family
A8B94_RS07305	COG0028	Belongs to the TPP enzyme family
A8B94_RS07310	COG0583	DNA-binding transcription factor activity
A8B94_RS07315	COG4974	Belongs to the 'phage' integrase family
A8B94_RS07320	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A8B94_RS07325	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A8B94_RS07340	COG1686	Belongs to the peptidase S11 family
A8B94_RS07350	COG2814	Major facilitator Superfamily
A8B94_RS07360	COG1074	ATP-dependent DNA helicase activity
A8B94_RS07370	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A8B94_RS07375	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A8B94_RS07380	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A8B94_RS07400	COG2321	neutral zinc metallopeptidase
A8B94_RS07405	COG0009	L-threonylcarbamoyladenylate synthase
A8B94_RS07445	COG3360	Dodecin
A8B94_RS07450	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A8B94_RS07455	COG2850	peptidyl-arginine hydroxylation
A8B94_RS07460	COG3539	Fimbrial protein
A8B94_RS07465	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
A8B94_RS07470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8B94_RS07475	COG1994	Peptidase M50
A8B94_RS07485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8B94_RS07490	COG0765	amino acid transport
A8B94_RS07495	COG1126	abc transporter atp-binding protein
A8B94_RS07500	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A8B94_RS07505	COG1758	RNA polymerase activity
A8B94_RS07510	COG0194	GDP metabolic process
A8B94_RS07515	COG3258	Cytochrome c
A8B94_RS07520	COG2863	cytochrome
A8B94_RS07525	COG1028	Short-chain dehydrogenase reductase Sdr
A8B94_RS07530	COG0791	NLP P60 protein
A8B94_RS07535	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A8B94_RS07555	COG1561	YicC-like family, N-terminal region
A8B94_RS07560	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A8B94_RS07575	COG2200	EAL domain
A8B94_RS07575	COG2199	diguanylate cyclase activity
A8B94_RS07580	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A8B94_RS07590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A8B94_RS07595	COG0174	glutamine synthetase
A8B94_RS07605	COG2204	response regulator
A8B94_RS07610	COG0583	DNA-binding transcription factor activity
A8B94_RS07615	COG1741	Belongs to the pirin family
A8B94_RS07620	COG1741	Belongs to the pirin family
A8B94_RS07630	COG3842	ATPase activity
A8B94_RS07635	COG1178	ABC-type Fe3 transport system permease component
A8B94_RS07640	COG1840	ABC-type Fe3 transport system, periplasmic component
A8B94_RS07650	COG0583	DNA-binding transcription factor activity
A8B94_RS07660	COG0656	L-ascorbic acid biosynthetic process
A8B94_RS07675	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A8B94_RS07680	COG0583	DNA-binding transcription factor activity
A8B94_RS07695	COG0783	Belongs to the Dps family
A8B94_RS07730	COG0438	transferase activity, transferring glycosyl groups
A8B94_RS07745	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A8B94_RS07770	COG0300	oxidoreductase activity
A8B94_RS07815	COG0861	Integral membrane protein TerC family
A8B94_RS07820	COG1028	Short-chain dehydrogenase reductase Sdr
A8B94_RS07840	COG0714	Associated with various cellular activities
A8B94_RS07870	COG3119	arylsulfatase activity
A8B94_RS07895	COG2197	response regulator
A8B94_RS07905	COG2944	sequence-specific DNA binding
A8B94_RS07910	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
A8B94_RS07915	COG0625	glutathione transferase activity
A8B94_RS07945	COG0179	Fumarylacetoacetate (FAA) hydrolase
A8B94_RS07950	COG1028	Short-chain dehydrogenase reductase Sdr
A8B94_RS07995	COG0431	NADPH-dependent FMN reductase
A8B94_RS08025	COG1028	Short-chain dehydrogenase reductase Sdr
A8B94_RS08030	COG0583	DNA-binding transcription factor activity
A8B94_RS08045	COG3181	Tripartite tricarboxylate transporter family receptor
A8B94_RS08050	COG2111	Na H antiporter
A8B94_RS08050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A8B94_RS08055	COG1006	Multisubunit Na H antiporter MnhC subunit
A8B94_RS08060	COG0651	ATP synthesis coupled electron transport
A8B94_RS08065	COG1863	multisubunit Na H antiporter MnhE subunit
A8B94_RS08070	COG2212	antiporter activity
A8B94_RS08095	COG0590	tRNA wobble adenosine to inosine editing
A8B94_RS08100	COG1619	proteins homologs of microcin C7 resistance protein MccF
A8B94_RS08105	COG1024	Enoyl-CoA hydratase
A8B94_RS08120	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A8B94_RS08125	COG0488	(ABC) transporter
A8B94_RS08160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A8B94_RS08160	COG1017	nitric oxide dioxygenase activity
A8B94_RS08165	COG1959	2 iron, 2 sulfur cluster binding
A8B94_RS08170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8B94_RS08190	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A8B94_RS08195	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A8B94_RS08200	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A8B94_RS08205	COG0084	hydrolase, TatD family'
A8B94_RS08220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8B94_RS08230	COG1126	abc transporter atp-binding protein
A8B94_RS08235	COG0010	Belongs to the arginase family
A8B94_RS08240	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A8B94_RS08245	COG1012	belongs to the aldehyde dehydrogenase family
A8B94_RS08255	COG0028	Belongs to the TPP enzyme family
A8B94_RS08265	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A8B94_RS08265	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8B94_RS08275	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8B94_RS08290	COG3189	MarR family transcriptional regulator
A8B94_RS08315	COG4336	lyase activity
A8B94_RS08325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8B94_RS08325	COG2205	protein histidine kinase activity
A8B94_RS08330	COG2197	response regulator
A8B94_RS08345	COG3121	Chaperone
A8B94_RS08350	COG3188	usher protein
A8B94_RS08355	COG3539	Fimbrial protein
A8B94_RS08360	COG2831	hemolysin activation secretion protein
A8B94_RS08375	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8B94_RS08400	COG0583	DNA-binding transcription factor activity
A8B94_RS08425	COG0668	transmembrane transport
A8B94_RS08445	COG0483	inositol monophosphate 1-phosphatase activity
A8B94_RS08450	COG1253	flavin adenine dinucleotide binding
A8B94_RS08455	COG1968	undecaprenyl-diphosphatase activity
A8B94_RS08460	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A8B94_RS08475	COG0215	cysteine-tRNA ligase activity
A8B94_RS08485	COG0825	malonyl-CoA metabolic process
A8B94_RS08495	COG0037	tRNA processing
A8B94_RS08500	COG0527	aspartate kinase activity
A8B94_RS08525	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8B94_RS08530	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8B94_RS08530	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A8B94_RS08545	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A8B94_RS08550	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
A8B94_RS08555	COG1028	Short-chain dehydrogenase reductase Sdr
A8B94_RS08565	COG0583	DNA-binding transcription factor activity
A8B94_RS08595	COG3842	ATPase activity
A8B94_RS08605	COG0446	pyridine nucleotide-disulphide oxidoreductase
A8B94_RS08605	COG1902	pentaerythritol trinitrate reductase activity
A8B94_RS08610	COG1414	Transcriptional regulator
A8B94_RS08615	COG1832	CoA-binding protein
A8B94_RS08625	COG0251	oxidation-reduction process
A8B94_RS08650	COG1902	pentaerythritol trinitrate reductase activity
A8B94_RS08660	COG1215	transferase activity, transferring glycosyl groups
A8B94_RS08665	COG1649	PFAM Uncharacterised BCR, COG1649
A8B94_RS08665	COG0726	polysaccharide deacetylase
A8B94_RS08685	COG1846	Transcriptional regulator
A8B94_RS08700	COG3468	outer membrane autotransporter barrel domain protein
A8B94_RS08705	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A8B94_RS08715	COG0556	nucleotide-excision repair
A8B94_RS08720	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A8B94_RS08730	COG1104	cysteine desulfurase activity
A8B94_RS08735	COG0822	iron-sulfur transferase activity
A8B94_RS08740	COG0316	Belongs to the HesB IscA family
A8B94_RS08745	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A8B94_RS08750	COG0443	Heat shock 70 kDa protein
A8B94_RS08755	COG0633	Ferredoxin
A8B94_RS08775	COG1024	Enoyl-CoA hydratase
A8B94_RS08790	COG3395	kinase activity
A8B94_RS08795	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A8B94_RS08810	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A8B94_RS08820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8B94_RS08845	COG0747	negative chemotaxis
A8B94_RS08850	COG0601	transmembrane transport
A8B94_RS08855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8B94_RS08860	COG4172	Belongs to the ABC transporter superfamily
A8B94_RS08865	COG0154	amidase activity
A8B94_RS08910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A8B94_RS08915	COG0425	Belongs to the sulfur carrier protein TusA family
A8B94_RS08925	COG0228	four-way junction DNA binding
A8B94_RS08930	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A8B94_RS08935	COG0336	Belongs to the RNA methyltransferase TrmD family
A8B94_RS08940	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A8B94_RS08955	COG0642	Histidine kinase
A8B94_RS08970	COG0525	valine-tRNA ligase activity
A8B94_RS08975	COG0105	UTP biosynthetic process
A8B94_RS08980	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A8B94_RS08990	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A8B94_RS08995	COG0124	histidyl-tRNA synthetase
A8B94_RS09000	COG2976	Protein conserved in bacteria
A8B94_RS09005	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A8B94_RS09010	COG1160	GTP binding
A8B94_RS09015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A8B94_RS09020	COG1923	regulation of RNA biosynthetic process
A8B94_RS09025	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A8B94_RS09030	COG0330	HflC and HflK could
A8B94_RS09035	COG0330	HflC and HflK could
A8B94_RS09040	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A8B94_RS09045	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A8B94_RS09050	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A8B94_RS09055	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A8B94_RS09065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A8B94_RS09095	COG0628	permease
A8B94_RS09100	COG0842	Transport permease protein
A8B94_RS09105	COG1131	(ABC) transporter
A8B94_RS09175	COG0156	8-amino-7-oxononanoate synthase activity
A8B94_RS09185	COG4106	trans-aconitate 2-methyltransferase activity
A8B94_RS09185	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A8B94_RS09190	COG1380	Effector of murein hydrolase LrgA
A8B94_RS09195	COG1346	cytolysis
A8B94_RS09210	COG3284	Transcriptional regulator
A8B94_RS09215	COG1012	belongs to the aldehyde dehydrogenase family
A8B94_RS09230	COG2733	membrane
A8B94_RS09235	COG0583	DNA-binding transcription factor activity
A8B94_RS09240	COG0384	phenazine biosynthesis protein PhzF
A8B94_RS09245	COG5507	3-demethylubiquinone-9 3-methyltransferase
A8B94_RS09250	COG2169	Transcriptional regulator
A8B94_RS09280	COG0659	secondary active sulfate transmembrane transporter activity
A8B94_RS09305	COG1132	(ABC) transporter
A8B94_RS09350	COG2207	Transcriptional regulator
A8B94_RS09480	COG2346	COG2346, Truncated hemoglobins
A8B94_RS09505	COG0583	DNA-binding transcription factor activity
A8B94_RS09510	COG4692	amylo-alpha-1,6-glucosidase activity
A8B94_RS09520	COG0183	Belongs to the thiolase family
A8B94_RS09535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B94_RS09540	COG0633	Ferredoxin
A8B94_RS09550	COG1024	Enoyl-CoA hydratase
A8B94_RS09560	COG4638	Rieske (2fe-2S)
A8B94_RS09570	COG0559	Belongs to the binding-protein-dependent transport system permease family
A8B94_RS09590	COG2224	Isocitrate lyase
A8B94_RS09595	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A8B94_RS09595	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A8B94_RS09610	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A8B94_RS09615	COG0322	excinuclease ABC activity
A8B94_RS09620	COG1472	Belongs to the glycosyl hydrolase 3 family
A8B94_RS09625	COG0736	holo-[acyl-carrier-protein] synthase activity
A8B94_RS09630	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A8B94_RS09640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A8B94_RS09645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8B94_RS09670	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A8B94_RS09685	COG2032	superoxide dismutase activity
A8B94_RS09700	COG1024	Enoyl-CoA hydratase
A8B94_RS09710	COG1802	Transcriptional regulator
A8B94_RS09720	COG0183	Belongs to the thiolase family
A8B94_RS09725	COG1942	4-Oxalocrotonate Tautomerase
A8B94_RS09735	COG4176	ABC-type proline glycine betaine transport system permease component
A8B94_RS09750	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A8B94_RS09755	COG2814	Major facilitator Superfamily
A8B94_RS09760	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A8B94_RS09765	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A8B94_RS09795	COG2814	Major facilitator Superfamily
A8B94_RS09800	COG0495	leucyl-tRNA aminoacylation
A8B94_RS09815	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A8B94_RS09825	COG0154	amidase activity
A8B94_RS09830	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8B94_RS09885	COG0427	acetyl-CoA hydrolase
A8B94_RS09890	COG0583	DNA-binding transcription factor activity
A8B94_RS09905	COG0730	response to heat
A8B94_RS09910	COG0697	spore germination
A8B94_RS09945	COG2885	chlorophyll binding
A8B94_RS09970	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A8B94_RS09975	COG3384	dioxygenase
A8B94_RS09990	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A8B94_RS09995	COG3474	cytochrome
A8B94_RS10005	COG1595	DNA-templated transcription, initiation
A8B94_RS10020	COG2204	response regulator
A8B94_RS10060	COG4964	Belongs to the GSP D family
A8B94_RS10110	COG1846	Transcriptional regulator
A8B94_RS10115	COG4172	Belongs to the ABC transporter superfamily
A8B94_RS10120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8B94_RS10125	COG0601	transmembrane transport
A8B94_RS10130	COG0747	negative chemotaxis
A8B94_RS10140	COG0598	Magnesium transport protein CorA
A8B94_RS10145	COG0210	DNA helicase
A8B94_RS10160	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A8B94_RS10165	COG1012	belongs to the aldehyde dehydrogenase family
A8B94_RS10170	COG0483	inositol monophosphate 1-phosphatase activity
A8B94_RS10175	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A8B94_RS10185	COG1045	serine acetyltransferase
A8B94_RS10190	COG0166	Belongs to the GPI family
A8B94_RS10220	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A8B94_RS10235	COG1960	acyl-CoA dehydrogenase activity
A8B94_RS10240	COG1028	Short-chain dehydrogenase reductase Sdr
A8B94_RS10245	COG0183	Belongs to the thiolase family
A8B94_RS10255	COG1024	Enoyl-CoA hydratase
A8B94_RS10270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B94_RS10275	COG0583	DNA-binding transcription factor activity
A8B94_RS10280	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A8B94_RS10285	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A8B94_RS10290	COG0740	serine-type endopeptidase activity
A8B94_RS10295	COG0544	peptidyl-prolyl cis-trans isomerase activity
A8B94_RS10305	COG1278	Cold shock
A8B94_RS10315	COG1278	Cold shock
A8B94_RS10350	COG2171	N-acyltransferase activity
A8B94_RS10355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8B94_RS10360	COG2890	protein-(glutamine-N5) methyltransferase activity
A8B94_RS10365	COG0488	(ABC) transporter
A8B94_RS10370	COG4771	TonB-dependent receptor
A8B94_RS10375	COG0210	DNA helicase
A8B94_RS10395	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A8B94_RS10395	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A8B94_RS10400	COG0196	riboflavin kinase activity
A8B94_RS10405	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A8B94_RS10410	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A8B94_RS10415	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A8B94_RS10425	COG1522	sequence-specific DNA binding
A8B94_RS10440	COG2951	lytic endotransglycosylase activity
A8B94_RS10445	COG2833	Protein of unknown function (DUF455)
A8B94_RS10465	COG0189	ligase activity
A8B94_RS10465	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A8B94_RS10470	COG1181	Belongs to the D-alanine--D-alanine ligase family
A8B94_RS10470	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A8B94_RS10475	COG3237	CsbD-like
A8B94_RS10485	COG2823	Periplasmic or secreted lipoprotein
A8B94_RS10495	COG4181	ATPase activity
A8B94_RS10505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A8B94_RS10510	COG0584	glycerophosphoryl diester phosphodiesterase
A8B94_RS10515	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A8B94_RS10525	COG0678	peroxiredoxin activity
A8B94_RS10525	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A8B94_RS10535	COG0789	Transcriptional regulator
A8B94_RS10540	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A8B94_RS10570	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A8B94_RS10575	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A8B94_RS10585	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A8B94_RS10590	COG2252	PERMEase
A8B94_RS10600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8B94_RS10635	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A8B94_RS10640	COG2358	TRAP transporter, solute receptor (TAXI family
A8B94_RS10675	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A8B94_RS10680	COG1366	Belongs to the anti-sigma-factor antagonist family
A8B94_RS10685	COG2172	sigma factor antagonist activity
A8B94_RS10690	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A8B94_RS10700	COG2208	phosphoserine phosphatase activity
A8B94_RS10700	COG2770	Histidine kinase
A8B94_RS10725	COG1595	DNA-templated transcription, initiation
A8B94_RS10740	COG4792	protein secretion
A8B94_RS10745	COG4791	protein targeting
A8B94_RS10750	COG4794	Type iii secretion
A8B94_RS10755	COG4790	Type iii secretion
A8B94_RS10790	COG4669	(LipO)protein
A8B94_RS10855	COG4789	Type iii secretion
A8B94_RS10885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A8B94_RS10890	COG0840	transmembrane signaling receptor activity
A8B94_RS10895	COG2233	PERMEase
A8B94_RS10915	COG0492	ferredoxin-NADP+ reductase activity
A8B94_RS10920	COG1840	ABC-type Fe3 transport system, periplasmic component
A8B94_RS10925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A8B94_RS10930	COG1178	ABC-type Fe3 transport system permease component
A8B94_RS10935	COG3842	ATPase activity
A8B94_RS10940	COG0583	DNA-binding transcription factor activity
A8B94_RS10960	COG0501	Belongs to the peptidase M48B family
A8B94_RS10970	COG0697	spore germination
A8B94_RS10980	COG1846	Transcriptional regulator
A8B94_RS10990	COG1566	PFAM secretion protein HlyD family protein
A8B94_RS10995	COG2814	Major facilitator Superfamily
A8B94_RS11000	COG0473	3-isopropylmalate dehydrogenase activity
A8B94_RS11010	COG0747	negative chemotaxis
A8B94_RS11020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8B94_RS11035	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A8B94_RS11060	COG1012	belongs to the aldehyde dehydrogenase family
A8B94_RS11070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A8B94_RS11075	COG1115	amino acid carrier protein
A8B94_RS11080	COG0433	COG0433 Predicted ATPase
A8B94_RS11085	COG0217	transcriptional regulatory protein
A8B94_RS11090	COG0151	Belongs to the GarS family
A8B94_RS11095	COG0408	coproporphyrinogen oxidase activity
A8B94_RS11100	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A8B94_RS11105	COG0799	negative regulation of ribosome biogenesis
A8B94_RS11110	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A8B94_RS11115	COG0424	maF-like protein
A8B94_RS11120	COG3468	outer membrane autotransporter barrel domain protein
A8B94_RS11175	COG1530	ribonuclease E activity
A8B94_RS11180	COG0077	Prephenate dehydratase
A8B94_RS11195	COG1132	(ABC) transporter
A8B94_RS11200	COG0859	PFAM glycosyl transferase family 9
A8B94_RS11225	COG2194	sulfuric ester hydrolase activity
A8B94_RS11230	COG0438	transferase activity, transferring glycosyl groups
A8B94_RS11235	COG0463	Glycosyl transferase, family 2
A8B94_RS11240	COG0726	polysaccharide deacetylase
A8B94_RS11245	COG0438	transferase activity, transferring glycosyl groups
A8B94_RS11260	COG1643	Atp-dependent helicase
A8B94_RS11265	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A8B94_RS11265	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A8B94_RS11270	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
A8B94_RS11280	COG0704	Plays a role in the regulation of phosphate uptake
A8B94_RS11285	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A8B94_RS11290	COG1960	acyl-CoA dehydrogenase activity
A8B94_RS11315	COG1177	transmembrane transport
A8B94_RS11320	COG1176	ABC-type spermidine putrescine transport system, permease component I
A8B94_RS11325	COG3842	ATPase activity
A8B94_RS11330	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A8B94_RS11345	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A8B94_RS11350	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8B94_RS11360	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A8B94_RS11360	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8B94_RS11380	COG0372	Belongs to the citrate synthase family
A8B94_RS11385	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A8B94_RS11390	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A8B94_RS11395	COG1053	succinate dehydrogenase
A8B94_RS11400	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A8B94_RS11405	COG2009	succinate dehydrogenase
A8B94_RS11410	COG2188	Transcriptional regulator
A8B94_RS11415	COG0039	L-malate dehydrogenase activity
A8B94_RS11445	COG1981	membrane
A8B94_RS11470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A8B94_RS11480	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A8B94_RS11510	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A8B94_RS11515	COG0148	phosphopyruvate hydratase activity
A8B94_RS11525	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A8B94_RS11530	COG0504	CTP synthase activity
A8B94_RS11555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8B94_RS11565	COG0747	negative chemotaxis
A8B94_RS11570	COG4172	Belongs to the ABC transporter superfamily
A8B94_RS11575	COG1446	asparaginase
A8B94_RS11605	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A8B94_RS11620	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
A8B94_RS11625	COG0697	spore germination
A8B94_RS11630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A8B94_RS11640	COG3193	protein, possibly involved in utilization of glycolate and propanediol
A8B94_RS11645	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A8B94_RS11650	COG0791	NLP P60 protein
A8B94_RS11665	COG0583	DNA-binding transcription factor activity
A8B94_RS11680	COG0583	DNA-binding transcription factor activity
A8B94_RS11690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A8B94_RS11705	COG0670	Belongs to the BI1 family
A8B94_RS11710	COG3181	Tripartite tricarboxylate transporter family receptor
A8B94_RS11725	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A8B94_RS11735	COG1381	Involved in DNA repair and RecF pathway recombination
A8B94_RS11740	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A8B94_RS11745	COG0571	ribonuclease III activity
A8B94_RS11750	COG0681	Belongs to the peptidase S26 family
A8B94_RS11755	COG0481	GTPase activity
A8B94_RS11760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8B94_RS11785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A8B94_RS11790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8B94_RS11805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A8B94_RS11810	COG0416	fatty acid biosynthetic process
A8B94_RS11815	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A8B94_RS11820	COG1399	metal-binding, possibly nucleic acid-binding protein
A8B94_RS11825	COG0424	maF-like protein
A8B94_RS11835	COG3023	N-Acetylmuramoyl-L-alanine amidase
A8B94_RS11840	COG1289	transmembrane transporter activity
A8B94_RS11850	COG3022	response to hydroperoxide
A8B94_RS11865	COG0135	phosphoribosylanthranilate isomerase activity
A8B94_RS11880	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A8B94_RS11885	COG0101	tRNA pseudouridine synthase activity
A8B94_RS11895	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A8B94_RS11900	COG0473	3-isopropylmalate dehydrogenase activity
A8B94_RS11905	COG0066	3-isopropylmalate dehydratase activity
A8B94_RS11910	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A8B94_RS11920	COG1122	ATPase activity
A8B94_RS11950	COG0437	4 iron, 4 sulfur cluster binding
A8B94_RS11955	COG0243	molybdopterin cofactor binding
A8B94_RS11955	COG3383	formate dehydrogenase (NAD+) activity
A8B94_RS11985	COG0489	protein tyrosine kinase activity
A8B94_RS11990	COG0746	molybdenum cofactor guanylyltransferase activity
A8B94_RS11995	COG0303	'Molybdopterin
A8B94_RS12000	COG1763	Mo-molybdopterin cofactor biosynthetic process
A8B94_RS12010	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A8B94_RS12015	COG5001	Diguanylate cyclase
A8B94_RS12035	COG3842	ATPase activity
A8B94_RS12045	COG0406	alpha-ribazole phosphatase activity
A8B94_RS12055	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A8B94_RS12060	COG0505	Belongs to the CarA family
A8B94_RS12065	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A8B94_RS12095	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A8B94_RS12100	COG1960	acyl-CoA dehydrogenase activity
A8B94_RS12110	COG2867	negative regulation of translational initiation
A8B94_RS12120	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A8B94_RS12125	COG3706	GGDEF domain
A8B94_RS12130	COG0330	HflC and HflK could
A8B94_RS12145	COG0519	Catalyzes the synthesis of GMP from XMP
A8B94_RS12145	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A8B94_RS12155	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A8B94_RS12160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A8B94_RS12165	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A8B94_RS12170	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A8B94_RS12180	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A8B94_RS12185	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A8B94_RS12190	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
A8B94_RS12195	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A8B94_RS12200	COG0750	zinc metalloprotease
A8B94_RS12205	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A8B94_RS12215	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A8B94_RS12220	COG0233	cytoplasmic translational termination
A8B94_RS12225	COG0528	UMP kinase activity
A8B94_RS12230	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A8B94_RS12235	COG0052	Belongs to the universal ribosomal protein uS2 family
A8B94_RS12240	COG0024	Methionine aminopeptidase
A8B94_RS12245	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A8B94_RS12275	COG0285	dihydrofolate synthase activity
A8B94_RS12310	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A8B94_RS12320	COG1677	Flagellar hook-basal body complex protein FliE
A8B94_RS12330	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A8B94_RS12340	COG1157	protein secretion by the type III secretion system
A8B94_RS12365	COG1580	Controls the rotational direction of flagella during chemotaxis
A8B94_RS12385	COG1338	Plays a role in the flagellum-specific transport system
A8B94_RS12405	COG0840	transmembrane signaling receptor activity
A8B94_RS12410	COG0840	transmembrane signaling receptor activity
A8B94_RS12415	COG0840	transmembrane signaling receptor activity
A8B94_RS12425	COG1256	bacterial-type flagellum assembly
A8B94_RS12435	COG1706	bacterial-type flagellum-dependent cell motility
A8B94_RS12440	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A8B94_RS12455	COG1749	Flagellar hook protein flgE
A8B94_RS12465	COG1558	bacterial-type flagellum-dependent cell motility
A8B94_RS12470	COG1815	bacterial-type flagellum-dependent cell motility
A8B94_RS12510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8B94_RS12515	COG0765	amino acid transport
A8B94_RS12520	COG1126	abc transporter atp-binding protein
A8B94_RS12535	COG4948	Mandelate Racemase Muconate Lactonizing
A8B94_RS12540	COG3181	Tripartite tricarboxylate transporter family receptor
A8B94_RS12550	COG0066	3-isopropylmalate dehydratase activity
A8B94_RS12565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B94_RS12575	COG3181	Tripartite tricarboxylate transporter family receptor
A8B94_RS12585	COG1802	Transcriptional regulator
A8B94_RS12600	COG0583	DNA-binding transcription factor activity
A8B94_RS12620	COG1695	Transcriptional regulator
A8B94_RS12625	COG3568	Endonuclease Exonuclease Phosphatase
A8B94_RS12630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A8B94_RS12670	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A8B94_RS12680	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A8B94_RS12690	COG1640	4-alpha-glucanotransferase
A8B94_RS12705	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A8B94_RS12735	COG0667	Aldo Keto reductase
A8B94_RS12750	COG2259	Doxx family
A8B94_RS12790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B94_RS12810	COG0386	Belongs to the glutathione peroxidase family
A8B94_RS12815	COG0625	glutathione transferase activity
A8B94_RS12830	COG0095	Lipoate-protein ligase
A8B94_RS12845	COG0688	phosphatidylethanolamine metabolic process
A8B94_RS12855	COG1464	Belongs to the NlpA lipoprotein family
A8B94_RS12870	COG2363	Small membrane protein
A8B94_RS12895	COG3842	ATPase activity
A8B94_RS12900	COG0395	ABC-type sugar transport system, permease component
A8B94_RS12905	COG1175	transmembrane transport
A8B94_RS12910	COG1653	transport
A8B94_RS12920	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A8B94_RS12935	COG0559	Belongs to the binding-protein-dependent transport system permease family
A8B94_RS12955	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A8B94_RS12970	COG0697	spore germination
A8B94_RS12985	COG2311	Membrane
A8B94_RS13010	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A8B94_RS13020	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A8B94_RS13025	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A8B94_RS13030	COG1760	l-serine dehydratase
A8B94_RS13035	COG1283	sodium-dependent phosphate transmembrane transporter activity
A8B94_RS13040	COG0412	Dienelactone hydrolase
A8B94_RS13055	COG1611	Belongs to the LOG family
A8B94_RS13075	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A8B94_RS13080	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A8B94_RS13085	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A8B94_RS13090	COG0195	Participates in both transcription termination and antitermination
A8B94_RS13090	COG2251	uridine kinase activity
A8B94_RS13095	COG0779	Required for maturation of 30S ribosomal subunits
A8B94_RS13100	COG1187	pseudouridine synthase activity
A8B94_RS13105	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A8B94_RS13115	COG0583	DNA-binding transcription factor activity
A8B94_RS13125	COG0523	cobalamin synthesis protein
A8B94_RS13145	COG0625	glutathione transferase activity
A8B94_RS13150	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A8B94_RS13155	COG1047	Peptidyl-prolyl cis-trans
A8B94_RS13160	COG2003	Belongs to the UPF0758 family
A8B94_RS13165	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A8B94_RS13170	COG3483	tryptophan 2,3-dioxygenase activity
A8B94_RS13175	COG0254	rRNA binding
A8B94_RS13185	COG0534	Mate efflux family protein
A8B94_RS13205	COG2304	oxidoreductase activity
A8B94_RS13225	COG1028	Short-chain dehydrogenase reductase Sdr
A8B94_RS13230	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A8B94_RS13235	COG1562	ergosterol biosynthetic process
A8B94_RS13240	COG1562	ergosterol biosynthetic process
A8B94_RS13245	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
A8B94_RS13245	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
A8B94_RS13250	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A8B94_RS13260	COG0842	Transport permease protein
A8B94_RS13265	COG1131	(ABC) transporter
A8B94_RS13285	COG1477	protein flavinylation
A8B94_RS13300	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
A8B94_RS13315	COG5564	TIM-barrel signal transduction protein
A8B94_RS13320	COG5441	Belongs to the UPF0261 family
A8B94_RS13330	COG3468	outer membrane autotransporter barrel domain protein
A8B94_RS13335	COG3468	outer membrane autotransporter barrel domain protein
A8B94_RS13345	COG0542	response to heat
A8B94_RS13350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A8B94_RS13365	COG0494	nUDIX hydrolase
A8B94_RS13370	COG3530	Putative quorum-sensing-regulated virulence factor
A8B94_RS13380	COG1595	DNA-templated transcription, initiation
A8B94_RS13385	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A8B94_RS13420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8B94_RS13425	COG0765	amino acid transport
A8B94_RS13430	COG0765	amino acid transport
A8B94_RS13455	COG3539	Fimbrial protein
A8B94_RS13465	COG2050	protein possibly involved in aromatic compounds catabolism
A8B94_RS13470	COG1024	Enoyl-CoA hydratase
A8B94_RS13475	COG1012	belongs to the aldehyde dehydrogenase family
A8B94_RS13485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A8B94_RS13490	COG2151	metal-sulfur cluster biosynthetic enzyme
A8B94_RS13495	COG3396	Phenylacetate-CoA oxygenase
A8B94_RS13500	COG3460	Phenylacetate-CoA oxygenase
A8B94_RS13505	COG3396	Phenylacetate-CoA oxygenase
A8B94_RS13510	COG3327	negative regulation of DNA-templated transcription, initiation
A8B94_RS13520	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A8B94_RS13525	COG0501	Belongs to the peptidase M48B family
A8B94_RS13530	COG1162	GTPase activity
A8B94_RS13535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8B94_RS13540	COG0601	transmembrane transport
A8B94_RS13545	COG0747	negative chemotaxis
A8B94_RS13590	COG0668	transmembrane transport
A8B94_RS13595	COG0165	Argininosuccinate lyase
A8B94_RS13615	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A8B94_RS13620	COG0303	'Molybdopterin
A8B94_RS13625	COG0521	Mo-molybdopterin cofactor biosynthetic process
A8B94_RS13640	COG0315	cyclic pyranopterin monophosphate synthase activity
A8B94_RS13650	COG0412	Dienelactone hydrolase
A8B94_RS13660	COG0678	peroxiredoxin activity
A8B94_RS13670	COG0697	spore germination
A8B94_RS13675	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A8B94_RS13700	COG0789	Transcriptional regulator
A8B94_RS13720	COG1028	Short-chain dehydrogenase reductase Sdr
A8B94_RS13730	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A8B94_RS13735	COG1845	cytochrome c oxidase, subunit III
A8B94_RS13740	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A8B94_RS13750	COG0477	Major facilitator Superfamily
A8B94_RS13780	COG3468	outer membrane autotransporter barrel domain protein
A8B94_RS13790	COG1309	transcriptional regulator
A8B94_RS13795	COG2271	Major facilitator Superfamily
A8B94_RS13830	COG0506	proline dehydrogenase activity
A8B94_RS13830	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A8B94_RS13830	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A8B94_RS13840	COG3008	intermembrane lipid transfer
A8B94_RS13840	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A8B94_RS13845	COG2995	paraquat-inducible protein a
A8B94_RS13850	COG0542	response to heat
A8B94_RS13855	COG4953	penicillin-binding protein 1C
A8B94_RS13865	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A8B94_RS13870	COG1278	Cold shock
A8B94_RS13880	COG0183	Belongs to the thiolase family
A8B94_RS13885	COG0038	chloride channel
A8B94_RS13890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A8B94_RS13895	COG1570	exodeoxyribonuclease VII activity
A8B94_RS13905	COG0811	peptide transport
A8B94_RS13910	COG0848	biopolymer transport protein
A8B94_RS13915	COG1663	tetraacyldisaccharide 4'-kinase activity
A8B94_RS13920	COG2835	tetraacyldisaccharide 4'-kinase activity
A8B94_RS13925	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A8B94_RS13930	COG0563	adenylate kinase activity
A8B94_RS13940	COG0728	peptidoglycan biosynthetic process
A8B94_RS13950	COG0268	Binds directly to 16S ribosomal RNA
A8B94_RS13980	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A8B94_RS14005	COG0436	Aminotransferase
A8B94_RS14010	COG3737	Protein of unknown function (DUF498/DUF598)
A8B94_RS14015	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A8B94_RS14020	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A8B94_RS14025	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A8B94_RS14035	COG0305	Participates in initiation and elongation during chromosome replication
A8B94_RS14045	COG0359	binds to the 23S rRNA
A8B94_RS14050	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A8B94_RS14055	COG2965	DNA replication, synthesis of RNA primer
A8B94_RS14060	COG0360	Binds together with S18 to 16S ribosomal RNA
A8B94_RS14065	COG1469	GTP cyclohydrolase I activity
A8B94_RS14070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A8B94_RS14075	COG0142	geranyltranstransferase activity
A8B94_RS14080	COG1722	exodeoxyribonuclease VII activity
A8B94_RS14090	COG3181	Tripartite tricarboxylate transporter family receptor
A8B94_RS14110	COG2239	Acts as a magnesium transporter
A8B94_RS14120	COG2855	membrane
A8B94_RS14130	COG1473	amidohydrolase
A8B94_RS14135	COG0318	PFAM AMP-dependent synthetase and ligase
A8B94_RS14155	COG1501	Belongs to the glycosyl hydrolase 31 family
A8B94_RS14160	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A8B94_RS14165	COG2011	ABC-type metal ion transport system permease component
A8B94_RS14185	COG1454	alcohol dehydrogenase
A8B94_RS14210	COG2186	Transcriptional regulator
A8B94_RS14215	COG3181	Tripartite tricarboxylate transporter family receptor
A8B94_RS14235	COG1175	transmembrane transport
A8B94_RS14240	COG0395	ABC-type sugar transport system, permease component
A8B94_RS14245	COG3842	ATPase activity
A8B94_RS14250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A8B94_RS14260	COG1653	transport
A8B94_RS14280	COG2818	Glycosylase
A8B94_RS14285	COG2982	Protein involved in outer membrane biogenesis
A8B94_RS14295	COG1309	transcriptional regulator
A8B94_RS14300	COG1028	Short-chain dehydrogenase reductase Sdr
A8B94_RS14340	COG0583	DNA-binding transcription factor activity
A8B94_RS14345	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A8B94_RS14350	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A8B94_RS14365	COG1028	Short-chain dehydrogenase reductase Sdr
A8B94_RS14370	COG0477	Major facilitator Superfamily
A8B94_RS14380	COG0583	DNA-binding transcription factor activity
A8B94_RS14385	COG1448	Aminotransferase
A8B94_RS14390	COG1418	mRNA catabolic process
A8B94_RS14415	COG1063	alcohol dehydrogenase
A8B94_RS14435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8B94_RS14445	COG0318	PFAM AMP-dependent synthetase and ligase
A8B94_RS14455	COG1522	sequence-specific DNA binding
A8B94_RS14460	COG3181	Tripartite tricarboxylate transporter family receptor
A8B94_RS14465	COG0307	riboflavin synthase, alpha
A8B94_RS14470	COG0154	amidase activity
A8B94_RS14490	COG2807	transmembrane transport
A8B94_RS14495	COG0590	tRNA wobble adenosine to inosine editing
A8B94_RS14505	COG0583	DNA-binding transcription factor activity
A8B94_RS14520	COG1902	pentaerythritol trinitrate reductase activity
A8B94_RS14540	COG0559	Belongs to the binding-protein-dependent transport system permease family
A8B94_RS14545	COG0251	oxidation-reduction process
A8B94_RS14550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A8B94_RS14560	COG1414	Transcriptional regulator
A8B94_RS14565	COG1028	Short-chain dehydrogenase reductase Sdr
A8B94_RS14580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8B94_RS14595	COG1024	Enoyl-CoA hydratase
A8B94_RS14600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B94_RS14605	COG0154	amidase activity
A8B94_RS14645	COG3909	cytochrome
A8B94_RS14650	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A8B94_RS14655	COG0625	glutathione transferase activity
A8B94_RS14660	COG0730	response to heat
A8B94_RS14665	COG0482	sulfurtransferase activity
A8B94_RS14670	COG0583	DNA-binding transcription factor activity
A8B94_RS14705	COG2819	hydrolase of the alpha beta superfamily
A8B94_RS14710	COG0247	lactate metabolic process
A8B94_RS14715	COG0277	FAD linked oxidase domain protein
A8B94_RS14720	COG0277	FAD linked oxidase domain protein
A8B94_RS14725	COG0277	FAD linked oxidase domain protein
A8B94_RS14730	COG3210	domain, Protein
A8B94_RS14730	COG3064	Membrane
A8B94_RS14730	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
A8B94_RS14730	COG3064	Membrane
A8B94_RS14730	COG3210	domain, Protein
A8B94_RS14730	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
A8B94_RS14735	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A8B94_RS14740	COG0312	modulator of DNA gyrase
A8B94_RS14775	COG1666	GTP binding
A8B94_RS14820	COG3220	belongs to the UPF0276 family
A8B94_RS14840	COG0640	Transcriptional regulator
A8B94_RS14845	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A8B94_RS14850	COG1845	cytochrome c oxidase, subunit III
A8B94_RS14855	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A8B94_RS14865	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
A8B94_RS14900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B94_RS14905	COG0583	DNA-binding transcription factor activity
A8B94_RS14935	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A8B94_RS14935	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A8B94_RS14950	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A8B94_RS14955	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A8B94_RS14965	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A8B94_RS14980	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A8B94_RS14985	COG0316	Belongs to the HesB IscA family
A8B94_RS14995	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A8B94_RS15000	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A8B94_RS15005	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A8B94_RS15010	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A8B94_RS15015	COG0312	modulator of DNA gyrase
A8B94_RS15020	COG3028	Belongs to the UPF0307 family
A8B94_RS15035	COG1116	anion transmembrane transporter activity
A8B94_RS15040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8B94_RS15045	COG1335	isochorismatase
A8B94_RS15050	COG0346	lactoylglutathione lyase activity
A8B94_RS15055	COG0513	Belongs to the DEAD box helicase family
A8B94_RS15060	COG3069	C4-dicarboxylate transmembrane transporter activity
A8B94_RS15065	COG1802	Transcriptional regulator
A8B94_RS15075	COG1042	CoA-binding domain protein
A8B94_RS15075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8B94_RS15075	COG0045	succinate-CoA ligase (ADP-forming) activity
A8B94_RS15080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A8B94_RS15095	COG1522	sequence-specific DNA binding
A8B94_RS15130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8B94_RS15135	COG1696	Membrane protein involved in D-alanine export
A8B94_RS15160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8B94_RS15170	COG2264	protein methyltransferase activity
A8B94_RS15175	COG0439	Biotin carboxylase
A8B94_RS15180	COG0511	ligase activity, forming carbon-carbon bonds
A8B94_RS15185	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A8B94_RS15190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8B94_RS15195	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A8B94_RS15200	COG3150	esterase
A8B94_RS15205	COG0557	exoribonuclease II activity
A8B94_RS15215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A8B94_RS15235	COG1522	sequence-specific DNA binding
A8B94_RS15240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8B94_RS15245	COG1028	Short-chain dehydrogenase reductase Sdr
A8B94_RS15265	COG0653	protein targeting
A8B94_RS15270	COG0739	heme binding
A8B94_RS15280	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A8B94_RS15285	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A8B94_RS15295	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A8B94_RS15300	COG1181	Belongs to the D-alanine--D-alanine ligase family
A8B94_RS15305	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A8B94_RS15310	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A8B94_RS15320	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A8B94_RS15325	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A8B94_RS15330	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A8B94_RS15340	COG3116	cell division
A8B94_RS15345	COG0275	rRNA processing
A8B94_RS15350	COG2001	Belongs to the MraZ family
A8B94_RS15360	COG0488	(ABC) transporter
A8B94_RS15365	COG0418	dihydroorotase activity
A8B94_RS15370	COG1473	amidohydrolase
A8B94_RS15420	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A8B94_RS15425	COG4654	Cytochrome c, class I
A8B94_RS15430	COG0129	dihydroxy-acid dehydratase activity
A8B94_RS15435	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A8B94_RS15485	COG2084	Dehydrogenase
A8B94_RS15490	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A8B94_RS15505	COG2096	Adenosyltransferase
A8B94_RS15515	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A8B94_RS15520	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A8B94_RS15530	COG0523	cobalamin synthesis protein
A8B94_RS15535	COG0735	belongs to the Fur family
A8B94_RS15555	COG0803	Belongs to the bacterial solute-binding protein 9 family
A8B94_RS15565	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
A8B94_RS15575	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A8B94_RS15585	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A8B94_RS15590	COG1560	Kdo2-lipid A biosynthetic process
A8B94_RS15600	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A8B94_RS15615	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A8B94_RS15620	COG1950	PFAM Membrane protein of
A8B94_RS15635	COG0583	DNA-binding transcription factor activity
A8B94_RS15645	COG0477	Major facilitator Superfamily
A8B94_RS15660	COG0617	tRNA 3'-terminal CCA addition
A8B94_RS15670	COG0513	Belongs to the DEAD box helicase family
A8B94_RS15675	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A8B94_RS15685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A8B94_RS15690	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A8B94_RS15750	COG1280	lysine exporter protein (LysE YggA)
A8B94_RS15765	COG0405	Gamma-glutamyltransferase
A8B94_RS15775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8B94_RS15800	COG1309	transcriptional regulator
A8B94_RS15815	COG0745	RESPONSE REGULATOR receiver
A8B94_RS15860	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A8B94_RS15880	COG0582	viral genome integration into host DNA
A8B94_RS15885	COG0012	GTP binding
A8B94_RS15895	COG0193	aminoacyl-tRNA hydrolase activity
A8B94_RS15900	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A8B94_RS15905	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A8B94_RS15915	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A8B94_RS15920	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A8B94_RS15930	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A8B94_RS15955	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
A8B94_RS15965	COG1368	sulfuric ester hydrolase activity
A8B94_RS15970	COG0642	Histidine kinase
A8B94_RS15975	COG0745	RESPONSE REGULATOR receiver
A8B94_RS15980	COG0277	FAD linked oxidase domain protein
A8B94_RS15995	COG0166	Belongs to the GPI family
A8B94_RS16000	COG0438	transferase activity, transferring glycosyl groups
A8B94_RS16005	COG0438	transferase activity, transferring glycosyl groups
A8B94_RS16020	COG0438	transferase activity, transferring glycosyl groups
A8B94_RS16035	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A8B94_RS16040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A8B94_RS16045	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
A8B94_RS16055	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A8B94_RS16065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8B94_RS16070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A8B94_RS16080	COG0747	negative chemotaxis
A8B94_RS16085	COG0601	transmembrane transport
A8B94_RS16090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8B94_RS16110	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A8B94_RS16115	COG0830	nickel cation binding
A8B94_RS16125	COG0804	urea catabolic process
A8B94_RS16130	COG0832	Belongs to the urease beta subunit family
A8B94_RS16140	COG0831	urea catabolic process
A8B94_RS16145	COG0829	nickel cation binding
A8B94_RS16155	COG0633	Ferredoxin
A8B94_RS16170	COG2188	Transcriptional regulator
A8B94_RS16195	COG2719	SpoVR family
A8B94_RS16200	COG2718	Belongs to the UPF0229 family
A8B94_RS16215	COG1028	Short-chain dehydrogenase reductase Sdr
A8B94_RS16220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B94_RS16235	COG1960	acyl-CoA dehydrogenase activity
A8B94_RS16280	COG0183	Belongs to the thiolase family
A8B94_RS16285	COG2030	dehydratase
A8B94_RS16330	COG0328	RNA-DNA hybrid ribonuclease activity
A8B94_RS16335	COG2226	methyltransferase
A8B94_RS16340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8B94_RS16345	COG0741	lytic transglycosylase activity
A8B94_RS16345	COG1388	LysM domain
A8B94_RS16365	COG2979	Protein of unknown function (DUF533)
A8B94_RS16400	COG1271	oxidase subunit
A8B94_RS16405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A8B94_RS16410	COG0850	regulation of cytokinetic process
A8B94_RS16415	COG2894	cell division
A8B94_RS16420	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A8B94_RS16440	COG0488	(ABC) transporter
A8B94_RS16450	COG0601	transmembrane transport
A8B94_RS16460	COG1215	transferase activity, transferring glycosyl groups
A8B94_RS16475	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A8B94_RS16485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A8B94_RS16505	COG0318	PFAM AMP-dependent synthetase and ligase
A8B94_RS16510	COG2188	Transcriptional regulator
A8B94_RS16515	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A8B94_RS16520	COG2814	Major facilitator Superfamily
A8B94_RS16530	COG0259	pyridoxamine-phosphate oxidase activity
A8B94_RS16535	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A8B94_RS16550	COG0583	DNA-binding transcription factor activity
A8B94_RS16555	COG1960	acyl-CoA dehydrogenase activity
A8B94_RS16580	COG0134	indole-3-glycerol-phosphate synthase activity
A8B94_RS16585	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A8B94_RS16590	COG0512	Glutamine amidotransferase of anthranilate synthase
A8B94_RS16600	COG0546	phosphoglycolate phosphatase activity
A8B94_RS16605	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A8B94_RS16610	COG2967	ApaG domain
A8B94_RS16615	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A8B94_RS16620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A8B94_RS16625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A8B94_RS16630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8B94_RS16640	COG0037	tRNA processing
A8B94_RS16650	COG3634	alkyl hydroperoxide reductase activity
A8B94_RS16655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8B94_RS16660	COG1024	Enoyl-CoA hydratase
A8B94_RS16685	COG0356	it plays a direct role in the translocation of protons across the membrane
A8B94_RS16695	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A8B94_RS16700	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A8B94_RS16705	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A8B94_RS16710	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A8B94_RS16715	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A8B94_RS16720	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A8B94_RS16730	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A8B94_RS16735	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A8B94_RS16740	COG0210	DNA helicase
A8B94_RS16750	COG2195	Cleaves the N-terminal amino acid of tripeptides
A8B94_RS16760	COG4608	Belongs to the ABC transporter superfamily
A8B94_RS16765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8B94_RS16770	COG0601	transmembrane transport
A8B94_RS16790	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A8B94_RS16795	COG1024	Enoyl-CoA hydratase
A8B94_RS16800	COG1024	Enoyl-CoA hydratase
A8B94_RS16825	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8B94_RS16855	COG2132	Multicopper oxidase
A8B94_RS16865	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8B94_RS16865	COG1024	Enoyl-CoA hydratase
A8B94_RS16880	COG1414	Transcriptional regulator
A8B94_RS16890	COG0154	amidase activity
A8B94_RS16920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A8B94_RS16925	COG3568	Endonuclease Exonuclease Phosphatase
A8B94_RS16930	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A8B94_RS16965	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A8B94_RS16975	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A8B94_RS16990	COG1137	ATPase activity
A8B94_RS16995	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A8B94_RS17005	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A8B94_RS17010	COG2010	Cytochrome c
A8B94_RS17010	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A8B94_RS17020	COG1660	Displays ATPase and GTPase activities
A8B94_RS17025	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A8B94_RS17065	COG3181	Tripartite tricarboxylate transporter family receptor
A8B94_RS17075	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A8B94_RS17080	COG2890	protein-(glutamine-N5) methyltransferase activity
A8B94_RS17085	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A8B94_RS17090	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A8B94_RS17135	COG1960	acyl-CoA dehydrogenase activity
A8B94_RS17145	COG0183	Belongs to the thiolase family
A8B94_RS17150	COG1522	sequence-specific DNA binding
A8B94_RS17155	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A8B94_RS17175	COG1024	Enoyl-CoA hydratase
A8B94_RS17190	COG0604	alcohol dehydrogenase
A8B94_RS17210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8B94_RS17220	COG1960	acyl-CoA dehydrogenase activity
A8B94_RS17225	COG1960	acyl-CoA dehydrogenase activity
A8B94_RS17230	COG0277	FAD linked oxidase domain protein
A8B94_RS17240	COG3181	Tripartite tricarboxylate transporter family receptor
A8B94_RS17260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8B94_RS17270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B94_RS17275	COG3181	Tripartite tricarboxylate transporter family receptor
A8B94_RS17280	COG1960	acyl-CoA dehydrogenase activity
A8B94_RS17300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A8B94_RS17305	COG1024	Enoyl-CoA hydratase
A8B94_RS17310	COG1960	acyl-CoA dehydrogenase activity
A8B94_RS17330	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A8B94_RS17335	COG0022	dehydrogenase e1 component
A8B94_RS17340	COG1024	Enoyl-CoA hydratase
A8B94_RS17345	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8B94_RS17365	COG0683	leucine binding
A8B94_RS17370	COG0559	Belongs to the binding-protein-dependent transport system permease family
A8B94_RS17375	COG0411	ABC transporter
A8B94_RS17385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A8B94_RS17400	COG3181	Tripartite tricarboxylate transporter family receptor
A8B94_RS17425	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A8B94_RS17430	COG0793	Belongs to the peptidase S41A family
A8B94_RS17435	COG4942	peptidase
A8B94_RS17440	COG0588	phosphoglycerate mutase activity
A8B94_RS17445	COG1054	Belongs to the UPF0176 family
A8B94_RS17450	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A8B94_RS17455	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A8B94_RS17460	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A8B94_RS17465	COG3181	Tripartite tricarboxylate transporter family receptor
A8B94_RS17480	COG2226	methyltransferase
A8B94_RS17485	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A8B94_RS17500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8B94_RS17505	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A8B94_RS17530	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A8B94_RS17555	COG1335	isochorismatase
A8B94_RS17560	COG2309	aminopeptidase activity
A8B94_RS17565	COG0596	Alpha beta hydrolase
A8B94_RS17570	COG3473	Maleate cis-trans isomerase
A8B94_RS17580	COG2068	MobA-Related Protein
A8B94_RS17605	COG2204	response regulator
A8B94_RS17610	COG5000	phosphorelay sensor kinase activity
A8B94_RS17620	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A8B94_RS17620	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A8B94_RS17630	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
A8B94_RS17655	COG0583	DNA-binding transcription factor activity
A8B94_RS17670	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A8B94_RS17675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8B94_RS17680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8B94_RS17695	COG0758	DNA mediated transformation
A8B94_RS17700	COG1522	sequence-specific DNA binding
A8B94_RS17710	COG0242	peptide deformylase activity
A8B94_RS17720	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A8B94_RS17730	COG0546	phosphoglycolate phosphatase activity
A8B94_RS17750	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A8B94_RS17755	COG1942	4-Oxalocrotonate Tautomerase
A8B94_RS17760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8B94_RS17780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A8B94_RS17800	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A8B94_RS17805	COG1024	Enoyl-CoA hydratase
A8B94_RS17810	COG1414	Transcriptional regulator
A8B94_RS17815	COG0318	PFAM AMP-dependent synthetase and ligase
A8B94_RS17820	COG3181	Tripartite tricarboxylate transporter family receptor
A8B94_RS17850	COG0583	DNA-binding transcription factor activity
A8B94_RS17865	COG3422	double-strand break repair
A8B94_RS17870	COG0330	HflC and HflK could
A8B94_RS17880	COG0251	oxidation-reduction process
A8B94_RS17925	COG3723	Recombinational DNA repair protein, rece pathway
A8B94_RS17960	COG0582	viral genome integration into host DNA
A8B94_RS17985	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A8B94_RS17995	COG0706	membrane insertase activity
A8B94_RS18000	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A8B94_RS18005	COG0594	ribonuclease P activity
A8B94_RS18010	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A8B94_RS18015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A8B94_RS18030	COG1414	Transcriptional regulator
A8B94_RS18035	COG0154	amidase activity
A8B94_RS18050	COG1304	FMN binding
A8B94_RS18070	COG1960	acyl-CoA dehydrogenase activity
A8B94_RS18090	COG1960	acyl-CoA dehydrogenase activity
A8B94_RS18100	COG0183	Belongs to the thiolase family
A8B94_RS18105	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A8B94_RS18120	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A8B94_RS18125	COG3181	Tripartite tricarboxylate transporter family receptor
A8B94_RS18135	COG2358	TRAP transporter, solute receptor (TAXI family
A8B94_RS18145	COG1629	transport
A8B94_RS18150	COG2922	Belongs to the Smg family
A8B94_RS18175	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A8B94_RS18180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8B94_RS18185	COG1028	Short-chain dehydrogenase reductase Sdr
A8B94_RS18190	COG1012	belongs to the aldehyde dehydrogenase family
A8B94_RS18200	COG0028	Belongs to the TPP enzyme family
A8B94_RS18205	COG1522	sequence-specific DNA binding
A8B94_RS18210	COG3781	membrane
A8B94_RS18220	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A8B94_RS18240	COG4206	TonB-dependent receptor
A8B94_RS18245	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8B94_RS18250	COG2022	thiamine diphosphate biosynthetic process
A8B94_RS18255	COG0351	phosphomethylpyrimidine kinase
A8B94_RS18260	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A8B94_RS18275	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A8B94_RS18285	COG0628	permease
A8B94_RS18295	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A8B94_RS18305	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A8B94_RS18310	COG0049	tRNA binding
A8B94_RS18315	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A8B94_RS18320	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A8B94_RS18325	COG0051	transcription antitermination factor activity, RNA binding
A8B94_RS18330	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A8B94_RS18335	COG0088	Forms part of the polypeptide exit tunnel
A8B94_RS18340	COG0089	rRNA binding
A8B94_RS18345	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A8B94_RS18350	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A8B94_RS18355	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A8B94_RS18360	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A8B94_RS18365	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A8B94_RS18370	COG0255	Belongs to the universal ribosomal protein uL29 family
A8B94_RS18375	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A8B94_RS18395	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A8B94_RS18400	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A8B94_RS18405	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A8B94_RS18410	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A8B94_RS18415	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A8B94_RS18420	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A8B94_RS18425	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A8B94_RS18430	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A8B94_RS18435	COG1841	ribosomal large subunit assembly
A8B94_RS18440	COG0200	Binds to the 23S rRNA
A8B94_RS18445	COG0201	protein transport
A8B94_RS18450	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A8B94_RS18455	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A8B94_RS18460	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A8B94_RS18465	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A8B94_RS18470	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A8B94_RS18475	COG0202	RNA polymerase activity
A8B94_RS18480	COG0203	ribosomal protein L17
A8B94_RS18490	COG1324	tolerance protein
A8B94_RS18495	COG4232	protein-disulfide reductase activity
A8B94_RS18510	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A8B94_RS18520	COG1333	cytochrome c biogenesis protein
A8B94_RS18525	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A8B94_RS18535	COG1965	Belongs to the frataxin family
A8B94_RS18545	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A8B94_RS18550	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A8B94_RS18555	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A8B94_RS18570	COG2814	Major facilitator Superfamily
A8B94_RS18575	COG0629	single-stranded DNA binding
A8B94_RS18615	COG0402	S-adenosylhomocysteine deaminase activity
A8B94_RS18625	COG0438	transferase activity, transferring glycosyl groups
A8B94_RS18645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8B94_RS18670	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A8B94_RS18675	COG2186	Transcriptional regulator
A8B94_RS18695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8B94_RS18700	COG1956	GAF domain-containing protein
A8B94_RS18705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8B94_RS18715	COG1652	LysM domain
A8B94_RS18730	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A8B94_RS18745	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A8B94_RS18770	COG3181	Tripartite tricarboxylate transporter family receptor
A8B94_RS18785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8B94_RS18800	COG1024	Enoyl-CoA hydratase
A8B94_RS18815	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B94_RS18820	COG1309	transcriptional regulator
A8B94_RS18825	COG2816	NAD+ diphosphatase activity
A8B94_RS18830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A8B94_RS18915	COG2814	Major facilitator Superfamily
A8B94_RS18920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A8B94_RS18940	COG1999	signal sequence binding
A8B94_RS18945	COG0109	protoheme IX farnesyltransferase activity
A8B94_RS18985	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A8B94_RS19005	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A8B94_RS19010	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A8B94_RS19020	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A8B94_RS19025	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A8B94_RS19035	COG0069	glutamate synthase activity
A8B94_RS19035	COG0070	glutamate synthase
A8B94_RS19035	COG0067	glutamate synthase
A8B94_RS19045	COG3047	cAMP biosynthetic process
A8B94_RS19055	COG1127	ABC transporter
A8B94_RS19060	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A8B94_RS19065	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A8B94_RS19070	COG2853	Lipoprotein
A8B94_RS19080	COG1131	(ABC) transporter
A8B94_RS19085	COG0842	Transport permease protein
A8B94_RS19095	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A8B94_RS19100	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A8B94_RS19105	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A8B94_RS19110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A8B94_RS19115	COG0131	Imidazoleglycerol-phosphate dehydratase
A8B94_RS19120	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A8B94_RS19125	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A8B94_RS19130	COG0107	imidazoleglycerol-phosphate synthase activity
A8B94_RS19135	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A8B94_RS19140	COG0140	phosphoribosyl-ATP diphosphatase activity
A8B94_RS19145	COG0537	adenosine 5'-monophosphoramidase activity
A8B94_RS19150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A8B94_RS19155	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A8B94_RS19170	COG3181	Tripartite tricarboxylate transporter family receptor
A8B94_RS19205	COG3702	type iv secretory pathway
A8B94_RS19210	COG3451	type IV secretory pathway VirB4
A8B94_RS19225	COG3736	Type IV secretory pathway, component VirB8
A8B94_RS19230	COG3504	Conjugal transfer protein
A8B94_RS19235	COG2948	multi-organism process
A8B94_RS19240	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
A8B94_RS19250	COG0697	spore germination
A8B94_RS19270	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A8B94_RS19275	COG0747	negative chemotaxis
A8B94_RS19280	COG0601	transmembrane transport
A8B94_RS19285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8B94_RS19290	COG0444	Belongs to the ABC transporter superfamily
A8B94_RS19300	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A8B94_RS19310	COG0494	nUDIX hydrolase
A8B94_RS19350	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
A8B94_RS19355	COG0237	dephospho-CoA kinase activity
A8B94_RS19360	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A8B94_RS19375	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A8B94_RS19380	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A8B94_RS19390	COG0477	Major facilitator Superfamily
A8B94_RS19395	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A8B94_RS19410	COG1126	abc transporter atp-binding protein
A8B94_RS19415	COG0765	amino acid transport
A8B94_RS19420	COG4597	amino acid ABC transporter
A8B94_RS19425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8B94_RS19430	COG2884	Cell division ATP-binding protein ftsE
A8B94_RS19435	COG2177	Part of the ABC transporter FtsEX involved in
A8B94_RS19440	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A8B94_RS19450	COG1194	a g-specific adenine glycosylase
A8B94_RS19460	COG2226	methyltransferase
A8B94_RS19470	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B94_RS19475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B94_RS19490	COG1024	Enoyl-CoA hydratase
A8B94_RS19510	COG1024	Enoyl-CoA hydratase
A8B94_RS19515	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8B94_RS19520	COG3181	Tripartite tricarboxylate transporter family receptor
A8B94_RS19530	COG0753	catalase activity
A8B94_RS19535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8B94_RS19540	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A8B94_RS19550	COG2175	clavaminate synthase activity
A8B94_RS19555	COG1473	amidohydrolase
A8B94_RS19560	COG4608	Belongs to the ABC transporter superfamily
A8B94_RS19565	COG0444	Belongs to the ABC transporter superfamily
A8B94_RS19580	COG0747	negative chemotaxis
A8B94_RS19585	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A8B94_RS19620	COG0436	Aminotransferase
A8B94_RS19625	COG1278	Cold shock