locus-tag	class	description
AKI39_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AKI39_RS00025	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
AKI39_RS00030	COG1960	acyl-CoA dehydrogenase activity
AKI39_RS00045	COG0583	DNA-binding transcription factor activity
AKI39_RS00075	COG0583	DNA-binding transcription factor activity
AKI39_RS00085	COG2175	clavaminate synthase activity
AKI39_RS00125	COG4948	Mandelate Racemase Muconate Lactonizing
AKI39_RS00130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKI39_RS00135	COG4948	Mandelate Racemase Muconate Lactonizing
AKI39_RS00150	COG0252	asparaginase activity
AKI39_RS00155	COG0583	DNA-binding transcription factor activity
AKI39_RS00160	COG0154	amidase activity
AKI39_RS00165	COG0683	leucine binding
AKI39_RS00170	COG0559	Belongs to the binding-protein-dependent transport system permease family
AKI39_RS00180	COG0411	ABC transporter
AKI39_RS00235	COG0179	Fumarylacetoacetate (FAA) hydrolase
AKI39_RS00250	COG0583	DNA-binding transcription factor activity
AKI39_RS00255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AKI39_RS00260	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AKI39_RS00265	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS00270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKI39_RS00310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AKI39_RS00310	COG1017	nitric oxide dioxygenase activity
AKI39_RS00315	COG1073	alpha beta
AKI39_RS00325	COG1522	sequence-specific DNA binding
AKI39_RS00340	COG2814	Major facilitator Superfamily
AKI39_RS00345	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AKI39_RS00365	COG1999	signal sequence binding
AKI39_RS00375	COG1612	heme a metabolic process
AKI39_RS00405	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AKI39_RS00415	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AKI39_RS00435	COG0129	dihydroxy-acid dehydratase activity
AKI39_RS00440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKI39_RS00445	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKI39_RS00450	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AKI39_RS00455	COG1609	Transcriptional regulator
AKI39_RS00465	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AKI39_RS00495	COG0070	glutamate synthase
AKI39_RS00495	COG0069	glutamate synthase activity
AKI39_RS00495	COG0067	glutamate synthase
AKI39_RS00505	COG3047	cAMP biosynthetic process
AKI39_RS00510	COG2059	Chromate
AKI39_RS00520	COG1127	ABC transporter
AKI39_RS00525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AKI39_RS00530	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AKI39_RS00535	COG2853	Lipoprotein
AKI39_RS00545	COG1131	(ABC) transporter
AKI39_RS00550	COG0842	Transport permease protein
AKI39_RS00560	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AKI39_RS00570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AKI39_RS00575	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AKI39_RS00580	COG0131	Imidazoleglycerol-phosphate dehydratase
AKI39_RS00590	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AKI39_RS00595	COG0107	imidazoleglycerol-phosphate synthase activity
AKI39_RS00600	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AKI39_RS00605	COG0140	phosphoribosyl-ATP diphosphatase activity
AKI39_RS00610	COG0537	adenosine 5'-monophosphoramidase activity
AKI39_RS00615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKI39_RS00620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKI39_RS00635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKI39_RS00640	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AKI39_RS00645	COG1970	mechanosensitive ion channel activity
AKI39_RS00650	COG0723	plastoquinol--plastocyanin reductase activity
AKI39_RS00655	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AKI39_RS00660	COG2857	Cytochrome c1
AKI39_RS00665	COG0625	glutathione transferase activity
AKI39_RS00700	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AKI39_RS00705	COG5339	Protein conserved in bacteria
AKI39_RS00710	COG0513	Belongs to the DEAD box helicase family
AKI39_RS00715	COG1280	lysine exporter protein (LysE YggA)
AKI39_RS00720	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AKI39_RS00740	COG0583	DNA-binding transcription factor activity
AKI39_RS00745	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AKI39_RS00760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKI39_RS00765	COG0395	ABC-type sugar transport system, permease component
AKI39_RS00770	COG1175	transmembrane transport
AKI39_RS00775	COG1653	transport
AKI39_RS00780	COG3842	ATPase activity
AKI39_RS00785	COG1609	Transcriptional regulator
AKI39_RS00790	COG0154	amidase activity
AKI39_RS00810	COG0018	arginyl-trna synthetase
AKI39_RS00820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AKI39_RS00830	COG1280	lysine exporter protein (LysE YggA)
AKI39_RS00835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKI39_RS00845	COG1960	acyl-CoA dehydrogenase activity
AKI39_RS00850	COG0183	Belongs to the thiolase family
AKI39_RS00855	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AKI39_RS00870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AKI39_RS00880	COG2922	Belongs to the Smg family
AKI39_RS00885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKI39_RS00900	COG1012	belongs to the aldehyde dehydrogenase family
AKI39_RS00905	COG0028	Belongs to the TPP enzyme family
AKI39_RS00910	COG1522	sequence-specific DNA binding
AKI39_RS00935	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AKI39_RS00950	COG0657	acetylesterase activity
AKI39_RS00965	COG4948	Mandelate Racemase Muconate Lactonizing
AKI39_RS00975	COG0683	leucine binding
AKI39_RS01000	COG3328	transposase activity
AKI39_RS01005	COG3328	transposase activity
AKI39_RS01010	COG3328	transposase activity
AKI39_RS01045	COG0318	PFAM AMP-dependent synthetase and ligase
AKI39_RS01080	COG1573	uracil-dna glycosylase
AKI39_RS01105	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
AKI39_RS01110	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AKI39_RS01155	COG0477	Major facilitator Superfamily
AKI39_RS01170	COG0066	3-isopropylmalate dehydratase activity
AKI39_RS01175	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AKI39_RS01180	COG2188	Transcriptional regulator
AKI39_RS01195	COG2814	Major facilitator Superfamily
AKI39_RS01200	COG4977	sequence-specific DNA binding
AKI39_RS01215	COG2188	Transcriptional regulator
AKI39_RS01230	COG1396	sequence-specific DNA binding
AKI39_RS01235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKI39_RS01240	COG0765	amino acid transport
AKI39_RS01245	COG1126	abc transporter atp-binding protein
AKI39_RS01250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKI39_RS01255	COG1178	ABC-type Fe3 transport system permease component
AKI39_RS01260	COG3842	ATPase activity
AKI39_RS01265	COG1176	ABC-type spermidine putrescine transport system, permease component I
AKI39_RS01275	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AKI39_RS01300	COG2124	cytochrome p450
AKI39_RS01310	COG2358	TRAP transporter, solute receptor (TAXI family
AKI39_RS01325	COG2132	Multicopper oxidase
AKI39_RS01330	COG0583	DNA-binding transcription factor activity
AKI39_RS01335	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AKI39_RS01340	COG1074	ATP-dependent DNA helicase activity
AKI39_RS01345	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AKI39_RS01350	COG0784	Response regulator, receiver
AKI39_RS01350	COG4191	Histidine kinase
AKI39_RS01360	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS01375	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS01405	COG1666	GTP binding
AKI39_RS01415	COG4208	sulfate ABC transporter
AKI39_RS01420	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AKI39_RS01430	COG2816	NAD+ diphosphatase activity
AKI39_RS01440	COG2823	Periplasmic or secreted lipoprotein
AKI39_RS01445	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AKI39_RS01455	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AKI39_RS01465	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AKI39_RS01470	COG1660	Displays ATPase and GTPase activities
AKI39_RS01485	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AKI39_RS01495	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AKI39_RS01500	COG1137	ATPase activity
AKI39_RS01525	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AKI39_RS01530	COG0747	negative chemotaxis
AKI39_RS01540	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AKI39_RS01545	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKI39_RS01555	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AKI39_RS01560	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AKI39_RS01565	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AKI39_RS01570	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AKI39_RS01575	COG0142	geranyltranstransferase activity
AKI39_RS01610	COG4106	trans-aconitate 2-methyltransferase activity
AKI39_RS01620	COG3403	YqcI/YcgG family
AKI39_RS01635	COG4977	sequence-specific DNA binding
AKI39_RS01650	COG2366	antibiotic biosynthetic process
AKI39_RS01660	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AKI39_RS01690	COG1053	succinate dehydrogenase
AKI39_RS01695	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AKI39_RS01710	COG2814	Major facilitator Superfamily
AKI39_RS01720	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
AKI39_RS01740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKI39_RS01745	COG0583	DNA-binding transcription factor activity
AKI39_RS01750	COG0583	DNA-binding transcription factor activity
AKI39_RS01775	COG0058	SHG alpha-glucan phosphorylase activity
AKI39_RS01840	COG0477	Major facilitator Superfamily
AKI39_RS01850	COG3459	Glycosyltransferase 36 associated
AKI39_RS01865	COG0840	transmembrane signaling receptor activity
AKI39_RS01870	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AKI39_RS01875	COG4589	Belongs to the CDS family
AKI39_RS01885	COG5499	transcription regulator containing HTH domain
AKI39_RS01895	COG4372	Transposase
AKI39_RS01905	COG0326	Molecular chaperone. Has ATPase activity
AKI39_RS01910	COG2271	Major facilitator Superfamily
AKI39_RS01915	COG4948	Mandelate Racemase Muconate Lactonizing
AKI39_RS01920	COG0800	Aldolase
AKI39_RS01925	COG3734	2-keto-3-deoxy-galactonokinase
AKI39_RS01930	COG1414	Transcriptional regulator
AKI39_RS01945	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AKI39_RS01950	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AKI39_RS01965	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AKI39_RS01995	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS02005	COG2226	methyltransferase
AKI39_RS02020	COG1177	transmembrane transport
AKI39_RS02025	COG1176	ABC-type spermidine putrescine transport system, permease component I
AKI39_RS02035	COG3842	ATPase activity
AKI39_RS02040	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AKI39_RS02050	COG0473	3-isopropylmalate dehydrogenase activity
AKI39_RS02070	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AKI39_RS02080	COG4948	Mandelate Racemase Muconate Lactonizing
AKI39_RS02085	COG0395	ABC-type sugar transport system, permease component
AKI39_RS02090	COG1175	transmembrane transport
AKI39_RS02095	COG3842	ATPase activity
AKI39_RS02100	COG1653	transport
AKI39_RS02105	COG0583	DNA-binding transcription factor activity
AKI39_RS02110	COG0583	DNA-binding transcription factor activity
AKI39_RS02115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKI39_RS02120	COG0625	glutathione transferase activity
AKI39_RS02135	COG2264	protein methyltransferase activity
AKI39_RS02140	COG0531	amino acid
AKI39_RS02155	COG1012	belongs to the aldehyde dehydrogenase family
AKI39_RS02165	COG0583	DNA-binding transcription factor activity
AKI39_RS02180	COG1054	Belongs to the UPF0176 family
AKI39_RS02185	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AKI39_RS02200	COG0489	protein tyrosine kinase activity
AKI39_RS02215	COG0717	Belongs to the dCTP deaminase family
AKI39_RS02230	COG2249	NAD(P)H dehydrogenase (quinone) activity
AKI39_RS02250	COG2081	HI0933 family
AKI39_RS02260	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AKI39_RS02265	COG0509	glycine decarboxylation via glycine cleavage system
AKI39_RS02270	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AKI39_RS02270	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AKI39_RS02275	COG3328	transposase activity
AKI39_RS02285	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AKI39_RS02290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKI39_RS02300	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AKI39_RS02310	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AKI39_RS02315	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AKI39_RS02330	COG0277	FAD linked oxidase domain protein
AKI39_RS02335	COG0745	RESPONSE REGULATOR receiver
AKI39_RS02340	COG2205	protein histidine kinase activity
AKI39_RS02350	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AKI39_RS02350	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKI39_RS02360	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKI39_RS02365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKI39_RS02370	COG2186	Transcriptional regulator
AKI39_RS02375	COG0179	Fumarylacetoacetate (FAA) hydrolase
AKI39_RS02380	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AKI39_RS02390	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AKI39_RS02400	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AKI39_RS02405	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AKI39_RS02415	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AKI39_RS02425	COG0193	aminoacyl-tRNA hydrolase activity
AKI39_RS02435	COG0493	'glutamate synthase
AKI39_RS02435	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AKI39_RS02440	COG0004	ammonium transporteR
AKI39_RS02450	COG0012	GTP binding
AKI39_RS02505	COG2814	Major facilitator Superfamily
AKI39_RS02510	COG1538	Outer membrane efflux protein
AKI39_RS02515	COG0842	Transport permease protein
AKI39_RS02520	COG1131	(ABC) transporter
AKI39_RS02545	COG3135	benzoate transporter
AKI39_RS02550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AKI39_RS02555	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AKI39_RS02560	COG0742	ribosomal rna small subunit methyltransferase
AKI39_RS02580	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AKI39_RS02585	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AKI39_RS02600	COG1546	Belongs to the CinA family
AKI39_RS02605	COG0284	orotidine-5'-phosphate decarboxylase activity
AKI39_RS02610	COG1252	NADH dehydrogenase
AKI39_RS02625	COG1063	alcohol dehydrogenase
AKI39_RS02630	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKI39_RS02640	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKI39_RS02645	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS02650	COG0179	Fumarylacetoacetate (FAA) hydrolase
AKI39_RS02655	COG2721	sulfolactate sulfo-lyase activity
AKI39_RS02660	COG4948	Mandelate Racemase Muconate Lactonizing
AKI39_RS02670	COG1289	transmembrane transporter activity
AKI39_RS02675	COG1295	ribonuclease BN
AKI39_RS02675	COG1959	2 iron, 2 sulfur cluster binding
AKI39_RS02705	COG4166	transmembrane transport
AKI39_RS02710	COG3328	transposase activity
AKI39_RS02720	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS02725	COG1024	Enoyl-CoA hydratase
AKI39_RS02745	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AKI39_RS02750	COG0352	thiamine-phosphate diphosphorylase activity
AKI39_RS02765	COG1678	Uncharacterized ACR, COG1678
AKI39_RS02770	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AKI39_RS02780	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AKI39_RS02790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AKI39_RS02795	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AKI39_RS02830	COG0557	exoribonuclease II activity
AKI39_RS02835	COG3150	esterase
AKI39_RS02840	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AKI39_RS02845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKI39_RS02850	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AKI39_RS02855	COG0511	ligase activity, forming carbon-carbon bonds
AKI39_RS02860	COG0439	Biotin carboxylase
AKI39_RS02865	COG2264	protein methyltransferase activity
AKI39_RS02875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AKI39_RS02885	COG0762	integral membrane protein
AKI39_RS02895	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKI39_RS02920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKI39_RS02935	COG3028	Belongs to the UPF0307 family
AKI39_RS02940	COG0312	modulator of DNA gyrase
AKI39_RS02950	COG0559	Belongs to the binding-protein-dependent transport system permease family
AKI39_RS02955	COG4177	L-phenylalanine transmembrane transporter activity
AKI39_RS02970	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AKI39_RS02975	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AKI39_RS02985	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AKI39_RS02995	COG0316	Belongs to the HesB IscA family
AKI39_RS03000	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AKI39_RS03005	COG0739	heme binding
AKI39_RS03010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AKI39_RS03015	COG1881	PFAM PEBP family protein
AKI39_RS03020	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AKI39_RS03025	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AKI39_RS03030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKI39_RS03030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKI39_RS03040	COG2766	serine protein kinase
AKI39_RS03045	COG2718	Belongs to the UPF0229 family
AKI39_RS03050	COG2719	SpoVR family
AKI39_RS03065	COG0601	transmembrane transport
AKI39_RS03070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKI39_RS03085	COG5295	Hep Hag repeat protein
AKI39_RS03090	COG1335	isochorismatase
AKI39_RS03100	COG0582	viral genome integration into host DNA
AKI39_RS03265	COG4695	Portal protein
AKI39_RS03330	COG0753	catalase activity
AKI39_RS03335	COG0628	permease
AKI39_RS03350	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS03355	COG5592	hemerythrin HHE cation binding domain
AKI39_RS03370	COG4566	intracellular signal transduction
AKI39_RS03395	COG1671	Belongs to the UPF0178 family
AKI39_RS03405	COG3214	Protein conserved in bacteria
AKI39_RS03415	COG0165	Argininosuccinate lyase
AKI39_RS03425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKI39_RS03450	COG0583	DNA-binding transcription factor activity
AKI39_RS03460	COG2814	Major facilitator Superfamily
AKI39_RS03465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AKI39_RS03480	COG0784	Response regulator, receiver
AKI39_RS03480	COG2198	Histidine kinase
AKI39_RS03480	COG2205	protein histidine kinase activity
AKI39_RS03485	COG2080	2 iron, 2 sulfur cluster binding
AKI39_RS03490	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AKI39_RS03495	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AKI39_RS03500	COG0667	Aldo Keto reductase
AKI39_RS03525	COG1388	LysM domain
AKI39_RS03525	COG0741	lytic transglycosylase activity
AKI39_RS03530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKI39_RS03535	COG2226	methyltransferase
AKI39_RS03540	COG0328	RNA-DNA hybrid ribonuclease activity
AKI39_RS03545	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AKI39_RS03565	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AKI39_RS03615	COG2814	Major facilitator Superfamily
AKI39_RS03620	COG1414	Transcriptional regulator
AKI39_RS03625	COG1024	Enoyl-CoA hydratase
AKI39_RS03650	COG4948	Mandelate Racemase Muconate Lactonizing
AKI39_RS03665	COG0583	DNA-binding transcription factor activity
AKI39_RS03675	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AKI39_RS03685	COG4166	transmembrane transport
AKI39_RS03690	COG0601	transmembrane transport
AKI39_RS03695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKI39_RS03700	COG0444	Belongs to the ABC transporter superfamily
AKI39_RS03705	COG4608	Belongs to the ABC transporter superfamily
AKI39_RS03710	COG0154	amidase activity
AKI39_RS03720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AKI39_RS03730	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKI39_RS03730	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AKI39_RS03735	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKI39_RS03740	COG0463	Glycosyl transferase, family 2
AKI39_RS03745	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AKI39_RS03760	COG1802	Transcriptional regulator
AKI39_RS03780	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AKI39_RS03790	COG0697	spore germination
AKI39_RS03795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKI39_RS03810	COG2223	nitrite transmembrane transporter activity
AKI39_RS03820	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AKI39_RS03825	COG3383	formate dehydrogenase (NAD+) activity
AKI39_RS03850	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AKI39_RS03855	COG0746	molybdenum cofactor guanylyltransferase activity
AKI39_RS03860	COG0303	'Molybdopterin
AKI39_RS03865	COG0521	Mo-molybdopterin cofactor biosynthetic process
AKI39_RS03880	COG0315	cyclic pyranopterin monophosphate synthase activity
AKI39_RS03890	COG0412	Dienelactone hydrolase
AKI39_RS03895	COG0678	peroxiredoxin activity
AKI39_RS04060	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AKI39_RS04065	COG0156	8-amino-7-oxononanoate synthase activity
AKI39_RS04120	COG0667	Aldo Keto reductase
AKI39_RS04125	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AKI39_RS04130	COG4535	Mg2 and Co2 transporter CorC
AKI39_RS04135	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AKI39_RS04140	COG1702	phosphate starvation-inducible protein PhoH
AKI39_RS04145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKI39_RS04165	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AKI39_RS04170	COG0531	amino acid
AKI39_RS04175	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AKI39_RS04185	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AKI39_RS04190	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AKI39_RS04195	COG1862	Preprotein translocase
AKI39_RS04200	COG0343	queuine tRNA-ribosyltransferase activity
AKI39_RS04205	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AKI39_RS04210	COG2027	D-alanyl-D-alanine carboxypeptidase
AKI39_RS04220	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AKI39_RS04220	COG1648	precorrin-2 dehydrogenase activity
AKI39_RS04230	COG4575	ribosome binding
AKI39_RS04245	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AKI39_RS04250	COG0741	lytic transglycosylase activity
AKI39_RS04255	COG0436	Aminotransferase
AKI39_RS04265	COG0280	phosphate acetyltransferase
AKI39_RS04265	COG0281	malic enzyme
AKI39_RS04275	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AKI39_RS04280	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AKI39_RS04285	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AKI39_RS04290	COG0126	phosphoglycerate kinase activity
AKI39_RS04295	COG0625	glutathione transferase activity
AKI39_RS04305	COG0484	heat shock protein binding
AKI39_RS04310	COG0521	Mo-molybdopterin cofactor biosynthetic process
AKI39_RS04330	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AKI39_RS04345	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AKI39_RS04350	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AKI39_RS04355	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AKI39_RS04360	COG3639	organic phosphonate transmembrane transporter activity
AKI39_RS04380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AKI39_RS04395	COG0439	Biotin carboxylase
AKI39_RS04400	COG0511	ligase activity, forming carbon-carbon bonds
AKI39_RS04410	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS04410	COG0604	alcohol dehydrogenase
AKI39_RS04410	COG3321	synthase
AKI39_RS04415	COG2175	clavaminate synthase activity
AKI39_RS04420	COG0583	DNA-binding transcription factor activity
AKI39_RS04425	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
AKI39_RS04430	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
AKI39_RS04435	COG3454	Phosphonate metabolism
AKI39_RS04440	COG2188	Transcriptional regulator
AKI39_RS04445	COG3624	Phosphonate C-P lyase system protein PhnG
AKI39_RS04455	COG3626	phosphonate metabolism
AKI39_RS04460	COG3627	carbon phosphorus lyase activity
AKI39_RS04465	COG4107	phosphonate C-P lyase system protein PhnK
AKI39_RS04470	COG4778	phosphonate C-P lyase system protein PhnL
AKI39_RS04475	COG3454	Phosphonate metabolism
AKI39_RS04485	COG2885	chlorophyll binding
AKI39_RS04490	COG2199	diguanylate cyclase activity
AKI39_RS04520	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AKI39_RS04530	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AKI39_RS04535	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AKI39_RS04540	COG0009	L-threonylcarbamoyladenylate synthase
AKI39_RS04545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKI39_RS04555	COG2030	dehydratase
AKI39_RS04590	COG1960	acyl-CoA dehydrogenase activity
AKI39_RS04595	COG0028	Belongs to the TPP enzyme family
AKI39_RS04625	COG0765	amino acid transport
AKI39_RS04630	COG0765	amino acid transport
AKI39_RS04635	COG1126	abc transporter atp-binding protein
AKI39_RS04645	COG0579	oxidoreductase
AKI39_RS04655	COG0259	pyridoxamine-phosphate oxidase activity
AKI39_RS04670	COG2205	protein histidine kinase activity
AKI39_RS04675	COG0745	RESPONSE REGULATOR receiver
AKI39_RS04680	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AKI39_RS04695	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AKI39_RS04700	COG1414	Transcriptional regulator
AKI39_RS04710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AKI39_RS04715	COG0583	DNA-binding transcription factor activity
AKI39_RS04740	COG0488	(ABC) transporter
AKI39_RS04755	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AKI39_RS04760	COG2894	cell division
AKI39_RS04765	COG0850	regulation of cytokinetic process
AKI39_RS04775	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKI39_RS04785	COG1294	oxidase, subunit
AKI39_RS04805	COG0514	ATP-dependent DNA helicase (RecQ)
AKI39_RS04810	COG2255	four-way junction helicase activity
AKI39_RS04820	COG1090	epimerase
AKI39_RS04825	COG0632	four-way junction helicase activity
AKI39_RS04830	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AKI39_RS04850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKI39_RS04860	COG0006	proline dipeptidase activity
AKI39_RS04875	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AKI39_RS04925	COG0513	Belongs to the DEAD box helicase family
AKI39_RS04940	COG1058	Belongs to the CinA family
AKI39_RS04940	COG1546	Belongs to the CinA family
AKI39_RS04945	COG1414	Transcriptional regulator
AKI39_RS04960	COG0167	dihydroorotate dehydrogenase activity
AKI39_RS04965	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AKI39_RS04970	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AKI39_RS05035	COG0154	amidase activity
AKI39_RS05045	COG0300	oxidoreductase activity
AKI39_RS05050	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AKI39_RS05065	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AKI39_RS05070	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS05080	COG0387	Pfam Sodium calcium exchanger
AKI39_RS05090	COG0477	Major facilitator Superfamily
AKI39_RS05105	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AKI39_RS05110	COG1024	Enoyl-CoA hydratase
AKI39_RS05120	COG1802	Transcriptional regulator
AKI39_RS05170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKI39_RS05180	COG2080	2 iron, 2 sulfur cluster binding
AKI39_RS05185	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AKI39_RS05185	COG2010	Cytochrome c
AKI39_RS05220	COG1024	Enoyl-CoA hydratase
AKI39_RS05230	COG1802	Transcriptional regulator
AKI39_RS05235	COG1024	Enoyl-CoA hydratase
AKI39_RS05240	COG3618	amidohydrolase
AKI39_RS05245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AKI39_RS05255	COG0183	Belongs to the thiolase family
AKI39_RS05265	COG2267	carboxylic ester hydrolase activity
AKI39_RS05285	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS05290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKI39_RS05295	COG2079	MmgE PrpD family protein
AKI39_RS05305	COG1378	Sugar-specific transcriptional regulator TrmB
AKI39_RS05310	COG1809	phosphosulfolactate synthase activity
AKI39_RS05315	COG1053	succinate dehydrogenase
AKI39_RS05365	COG0604	alcohol dehydrogenase
AKI39_RS05370	COG4133	protoheme IX ABC transporter activity
AKI39_RS05390	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AKI39_RS05395	COG1138	Cytochrome C-type biogenesis protein
AKI39_RS05405	COG3088	subunit of a heme lyase
AKI39_RS05415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKI39_RS05425	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AKI39_RS05435	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS05440	COG1917	Cupin 2, conserved barrel domain protein
AKI39_RS05440	COG4977	sequence-specific DNA binding
AKI39_RS05445	COG2207	Transcriptional regulator
AKI39_RS05480	COG0625	glutathione transferase activity
AKI39_RS05570	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS05585	COG0583	DNA-binding transcription factor activity
AKI39_RS05590	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS05595	COG4948	Mandelate Racemase Muconate Lactonizing
AKI39_RS05600	COG2084	Dehydrogenase
AKI39_RS05605	COG3395	kinase activity
AKI39_RS05615	COG0235	Class ii aldolase
AKI39_RS05620	COG3622	Belongs to the hyi family
AKI39_RS05625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKI39_RS05635	COG1414	Transcriptional regulator
AKI39_RS05680	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AKI39_RS05685	COG0735	belongs to the Fur family
AKI39_RS05690	COG0497	DNA recombination
AKI39_RS05700	COG1420	regulation of RNA biosynthetic process
AKI39_RS05705	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AKI39_RS05710	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AKI39_RS05725	COG0484	heat shock protein binding
AKI39_RS05730	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS05745	COG0154	amidase activity
AKI39_RS05750	COG3038	cytochrome b561
AKI39_RS05775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKI39_RS05780	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AKI39_RS05785	COG1929	Belongs to the glycerate kinase type-1 family
AKI39_RS05790	COG0469	pyruvate kinase activity
AKI39_RS05795	COG0700	Nucleoside recognition
AKI39_RS05800	COG0242	peptide deformylase activity
AKI39_RS05810	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS05815	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AKI39_RS05830	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AKI39_RS05835	COG0751	glycine-tRNA ligase activity
AKI39_RS05840	COG0752	glycyl-tRNA synthetase alpha subunit
AKI39_RS05845	COG1024	Enoyl-CoA hydratase
AKI39_RS05865	COG0617	tRNA 3'-terminal CCA addition
AKI39_RS05880	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AKI39_RS05890	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AKI39_RS05895	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AKI39_RS05900	COG0586	Pfam SNARE associated Golgi protein
AKI39_RS05905	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKI39_RS05915	COG0114	fumarate hydratase activity
AKI39_RS05925	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AKI39_RS05945	COG1686	Belongs to the peptidase S11 family
AKI39_RS05970	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AKI39_RS05975	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AKI39_RS05980	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AKI39_RS05985	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AKI39_RS05990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AKI39_RS06000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKI39_RS06005	COG0505	Belongs to the CarA family
AKI39_RS06010	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AKI39_RS06020	COG0300	oxidoreductase activity
AKI39_RS06025	COG0406	alpha-ribazole phosphatase activity
AKI39_RS06030	COG2233	PERMEase
AKI39_RS06035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKI39_RS06045	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AKI39_RS06050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AKI39_RS06070	COG0248	Ppx GppA phosphatase
AKI39_RS06075	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AKI39_RS06095	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AKI39_RS06100	COG2188	Transcriptional regulator
AKI39_RS06105	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS06110	COG4948	Mandelate Racemase Muconate Lactonizing
AKI39_RS06120	COG0235	Class ii aldolase
AKI39_RS06125	COG0583	DNA-binding transcription factor activity
AKI39_RS06135	COG1902	pentaerythritol trinitrate reductase activity
AKI39_RS06160	COG0390	transport system, permease component
AKI39_RS06170	COG0402	S-adenosylhomocysteine deaminase activity
AKI39_RS06190	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS06200	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS06205	COG2146	nitrite reductase [NAD(P)H] activity
AKI39_RS06205	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AKI39_RS06210	COG2146	nitrite reductase [NAD(P)H] activity
AKI39_RS06210	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AKI39_RS06220	COG0456	acetyltransferase
AKI39_RS06250	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AKI39_RS06255	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS06265	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AKI39_RS06280	COG0583	DNA-binding transcription factor activity
AKI39_RS06290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AKI39_RS06320	COG1802	Transcriptional regulator
AKI39_RS06340	COG1137	ATPase activity
AKI39_RS06360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AKI39_RS06385	COG0583	DNA-binding transcription factor activity
AKI39_RS06390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKI39_RS06395	COG0583	DNA-binding transcription factor activity
AKI39_RS06405	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AKI39_RS06410	COG0066	3-isopropylmalate dehydratase activity
AKI39_RS06450	COG0523	cobalamin synthesis protein
AKI39_RS06455	COG2084	Dehydrogenase
AKI39_RS06460	COG3386	PFAM SMP-30 Gluconolaconase
AKI39_RS06470	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS06480	COG0583	DNA-binding transcription factor activity
AKI39_RS06485	COG0583	DNA-binding transcription factor activity
AKI39_RS06495	COG3189	MarR family transcriptional regulator
AKI39_RS06515	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AKI39_RS06530	COG0243	molybdopterin cofactor binding
AKI39_RS06535	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AKI39_RS06540	COG1116	anion transmembrane transporter activity
AKI39_RS06545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKI39_RS06550	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AKI39_RS06555	COG3707	response regulator
AKI39_RS06565	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKI39_RS06570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKI39_RS06595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKI39_RS06600	COG3485	protocatechuate 3,4-dioxygenase
AKI39_RS06630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AKI39_RS06640	COG0243	molybdopterin cofactor binding
AKI39_RS06650	COG4122	O-methyltransferase activity
AKI39_RS06655	COG3685	Protein conserved in bacteria
AKI39_RS06730	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AKI39_RS06735	COG0583	DNA-binding transcription factor activity
AKI39_RS06790	COG2321	neutral zinc metallopeptidase
AKI39_RS06795	COG0009	L-threonylcarbamoyladenylate synthase
AKI39_RS06800	COG1994	Peptidase M50
AKI39_RS06805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AKI39_RS06810	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AKI39_RS06820	COG2850	peptidyl-arginine hydroxylation
AKI39_RS06825	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AKI39_RS06830	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS06835	COG1902	pentaerythritol trinitrate reductase activity
AKI39_RS06840	COG0583	DNA-binding transcription factor activity
AKI39_RS06855	COG0583	DNA-binding transcription factor activity
AKI39_RS06875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKI39_RS06880	COG0765	amino acid transport
AKI39_RS06885	COG0765	amino acid transport
AKI39_RS06890	COG1126	abc transporter atp-binding protein
AKI39_RS06910	COG3328	transposase activity
AKI39_RS06925	COG0477	Major facilitator Superfamily
AKI39_RS06940	COG3360	Dodecin
AKI39_RS06955	COG0668	transmembrane transport
AKI39_RS06975	COG0483	inositol monophosphate 1-phosphatase activity
AKI39_RS06980	COG1253	flavin adenine dinucleotide binding
AKI39_RS06985	COG1968	undecaprenyl-diphosphatase activity
AKI39_RS06990	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKI39_RS06995	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AKI39_RS07015	COG0825	malonyl-CoA metabolic process
AKI39_RS07020	COG0037	tRNA processing
AKI39_RS07055	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AKI39_RS07070	COG0583	DNA-binding transcription factor activity
AKI39_RS07075	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AKI39_RS07080	COG0066	3-isopropylmalate dehydratase activity
AKI39_RS07115	COG4772	TonB-dependent receptor
AKI39_RS07160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AKI39_RS07190	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS07215	COG0028	Belongs to the TPP enzyme family
AKI39_RS07225	COG0583	DNA-binding transcription factor activity
AKI39_RS07240	COG1733	regulation of RNA biosynthetic process
AKI39_RS07245	COG5001	Diguanylate cyclase
AKI39_RS07255	COG0477	Major facilitator Superfamily
AKI39_RS07290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKI39_RS07295	COG0745	RESPONSE REGULATOR receiver
AKI39_RS07300	COG5002	protein histidine kinase activity
AKI39_RS07315	COG2197	response regulator
AKI39_RS07320	COG0297	glycogen (starch) synthase activity
AKI39_RS07325	COG0110	maltose O-acetyltransferase activity
AKI39_RS07335	COG0438	transferase activity, transferring glycosyl groups
AKI39_RS07355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKI39_RS07360	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AKI39_RS07375	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AKI39_RS07385	COG3206	protein involved in exopolysaccharide biosynthesis
AKI39_RS07385	COG0489	protein tyrosine kinase activity
AKI39_RS07390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AKI39_RS07395	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AKI39_RS07405	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AKI39_RS07410	COG1045	serine acetyltransferase
AKI39_RS07425	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKI39_RS07440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKI39_RS07450	COG0583	DNA-binding transcription factor activity
AKI39_RS07475	COG0598	Magnesium transport protein CorA
AKI39_RS07490	COG0601	transmembrane transport
AKI39_RS07495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKI39_RS07500	COG4172	Belongs to the ABC transporter superfamily
AKI39_RS07515	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AKI39_RS07535	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS07540	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AKI39_RS07580	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AKI39_RS07585	COG2878	Part of a membrane complex involved in electron transport
AKI39_RS07600	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AKI39_RS07610	COG0251	oxidation-reduction process
AKI39_RS07615	COG3228	Belongs to the MtfA family
AKI39_RS07620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AKI39_RS07625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AKI39_RS07630	COG0133	tryptophan synthase activity
AKI39_RS07635	COG0159	tryptophan synthase activity
AKI39_RS07640	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AKI39_RS07645	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AKI39_RS07650	COG1530	ribonuclease E activity
AKI39_RS07660	COG0546	phosphoglycolate phosphatase activity
AKI39_RS07665	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AKI39_RS07670	COG3023	N-Acetylmuramoyl-L-alanine amidase
AKI39_RS07680	COG0424	maF-like protein
AKI39_RS07690	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AKI39_RS07700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AKI39_RS07710	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS07715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AKI39_RS07720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AKI39_RS07745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKI39_RS07755	COG0681	Belongs to the peptidase S26 family
AKI39_RS07760	COG0571	ribonuclease III activity
AKI39_RS07765	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AKI39_RS07770	COG1381	Involved in DNA repair and RecF pathway recombination
AKI39_RS07800	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AKI39_RS07830	COG0583	DNA-binding transcription factor activity
AKI39_RS07840	COG0791	NLP P60 protein
AKI39_RS07850	COG3193	protein, possibly involved in utilization of glycolate and propanediol
AKI39_RS07860	COG3938	Belongs to the proline racemase family
AKI39_RS07865	COG1704	LemA family
AKI39_RS07870	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AKI39_RS07885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AKI39_RS07890	COG0697	spore germination
AKI39_RS07895	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AKI39_RS07930	COG3568	Endonuclease Exonuclease Phosphatase
AKI39_RS07935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKI39_RS07940	COG0392	lysyltransferase activity
AKI39_RS07950	COG1446	asparaginase
AKI39_RS07955	COG4172	Belongs to the ABC transporter superfamily
AKI39_RS07960	COG0747	negative chemotaxis
AKI39_RS07995	COG0504	CTP synthase activity
AKI39_RS08000	COG0148	phosphopyruvate hydratase activity
AKI39_RS08005	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AKI39_RS08015	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AKI39_RS08045	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AKI39_RS08050	COG1984	allophanate hydrolase subunit 2
AKI39_RS08060	COG1981	membrane
AKI39_RS08065	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AKI39_RS08080	COG0495	leucyl-tRNA aminoacylation
AKI39_RS08095	COG1764	response to oxidative stress
AKI39_RS08100	COG1846	Transcriptional regulator
AKI39_RS08105	COG1802	Transcriptional regulator
AKI39_RS08115	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS08130	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AKI39_RS08135	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AKI39_RS08140	COG2814	Major facilitator Superfamily
AKI39_RS08145	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AKI39_RS08155	COG0183	Belongs to the thiolase family
AKI39_RS08165	COG1802	Transcriptional regulator
AKI39_RS08175	COG1024	Enoyl-CoA hydratase
AKI39_RS08180	COG0318	PFAM AMP-dependent synthetase and ligase
AKI39_RS08200	COG4120	Belongs to the binding-protein-dependent transport system permease family
AKI39_RS08220	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AKI39_RS08225	COG0736	holo-[acyl-carrier-protein] synthase activity
AKI39_RS08235	COG0322	excinuclease ABC activity
AKI39_RS08240	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AKI39_RS08245	COG4948	Mandelate Racemase Muconate Lactonizing
AKI39_RS08250	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS08255	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AKI39_RS08255	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AKI39_RS08260	COG1131	(ABC) transporter
AKI39_RS08265	COG0842	Transport permease protein
AKI39_RS08270	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AKI39_RS08295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKI39_RS08300	COG0642	Histidine kinase
AKI39_RS08315	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AKI39_RS08345	COG1174	glycine betaine transport
AKI39_RS08380	COG0583	DNA-binding transcription factor activity
AKI39_RS08385	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AKI39_RS08395	COG0542	response to heat
AKI39_RS08400	COG0028	Belongs to the TPP enzyme family
AKI39_RS08405	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AKI39_RS08410	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AKI39_RS08420	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AKI39_RS08455	COG0662	Cupin 2, conserved barrel domain protein
AKI39_RS08460	COG5285	phytanoyl-CoA dioxygenase
AKI39_RS08465	COG3217	Mosc domain protein beta barrel domain protein
AKI39_RS08465	COG0633	Ferredoxin
AKI39_RS08470	COG2076	Multidrug Resistance protein
AKI39_RS08480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKI39_RS08490	COG3504	Conjugal transfer protein
AKI39_RS08530	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AKI39_RS08535	COG0425	Belongs to the sulfur carrier protein TusA family
AKI39_RS08540	COG0228	four-way junction DNA binding
AKI39_RS08545	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AKI39_RS08550	COG0336	Belongs to the RNA methyltransferase TrmD family
AKI39_RS08555	COG0525	valine-tRNA ligase activity
AKI39_RS08560	COG0105	UTP biosynthetic process
AKI39_RS08565	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AKI39_RS08585	COG2976	Protein conserved in bacteria
AKI39_RS08590	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AKI39_RS08595	COG1160	GTP binding
AKI39_RS08605	COG1923	regulation of RNA biosynthetic process
AKI39_RS08610	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AKI39_RS08615	COG0330	HflC and HflK could
AKI39_RS08620	COG0330	HflC and HflK could
AKI39_RS08625	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AKI39_RS08630	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AKI39_RS08640	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AKI39_RS08650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKI39_RS08665	COG1309	transcriptional regulator
AKI39_RS08690	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AKI39_RS08715	COG1178	ABC-type Fe3 transport system permease component
AKI39_RS08720	COG3842	ATPase activity
AKI39_RS08725	COG1840	ABC-type Fe3 transport system, periplasmic component
AKI39_RS08735	COG1297	OPT oligopeptide transporter protein
AKI39_RS08745	COG1686	Belongs to the peptidase S11 family
AKI39_RS08750	COG2423	ornithine cyclodeaminase activity
AKI39_RS08760	COG0477	Major facilitator Superfamily
AKI39_RS08800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKI39_RS08810	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AKI39_RS08850	COG2814	Major facilitator Superfamily
AKI39_RS08855	COG0540	Belongs to the ATCase OTCase family
AKI39_RS08875	COG0477	Major facilitator Superfamily
AKI39_RS08890	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AKI39_RS08895	COG2137	regulation of response to DNA damage stimulus
AKI39_RS08905	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AKI39_RS08915	COG0045	succinate-CoA ligase (ADP-forming) activity
AKI39_RS08920	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AKI39_RS08925	COG0861	Integral membrane protein TerC family
AKI39_RS08930	COG0861	Integral membrane protein TerC family
AKI39_RS08935	COG0181	hydroxymethylbilane synthase activity
AKI39_RS08955	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AKI39_RS09025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AKI39_RS09030	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AKI39_RS09030	COG0517	IMP dehydrogenase activity
AKI39_RS09035	COG1295	ribonuclease BN
AKI39_RS09045	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AKI39_RS09055	COG4251	negative regulation of phosphorylation
AKI39_RS09070	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AKI39_RS09085	COG0066	3-isopropylmalate dehydratase activity
AKI39_RS09090	COG0473	3-isopropylmalate dehydrogenase activity
AKI39_RS09095	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AKI39_RS09105	COG0101	tRNA pseudouridine synthase activity
AKI39_RS09110	COG0135	phosphoribosylanthranilate isomerase activity
AKI39_RS09125	COG2200	EAL domain
AKI39_RS09140	COG2197	response regulator
AKI39_RS09145	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AKI39_RS09150	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AKI39_RS09165	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKI39_RS09170	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AKI39_RS09175	COG4608	Belongs to the ABC transporter superfamily
AKI39_RS09185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKI39_RS09190	COG0601	transmembrane transport
AKI39_RS09210	COG0004	ammonium transporteR
AKI39_RS09215	COG0347	Belongs to the P(II) protein family
AKI39_RS09280	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AKI39_RS09285	COG2814	Major facilitator Superfamily
AKI39_RS09300	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AKI39_RS09305	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AKI39_RS09310	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AKI39_RS09315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKI39_RS09315	COG0072	phenylalanine-tRNA ligase activity
AKI39_RS09335	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AKI39_RS09340	COG0745	RESPONSE REGULATOR receiver
AKI39_RS09345	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AKI39_RS09395	COG5265	(ABC) transporter
AKI39_RS09400	COG0667	Aldo Keto reductase
AKI39_RS09405	COG0154	amidase activity
AKI39_RS09425	COG1917	Cupin 2, conserved barrel domain protein
AKI39_RS09425	COG4977	sequence-specific DNA binding
AKI39_RS09430	COG2223	nitrite transmembrane transporter activity
AKI39_RS09450	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AKI39_RS09465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AKI39_RS09470	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS09520	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AKI39_RS09530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AKI39_RS09540	COG0204	Acyl-transferase
AKI39_RS09560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKI39_RS09570	COG0587	DNA-directed DNA polymerase activity
AKI39_RS09630	COG1802	Transcriptional regulator
AKI39_RS09640	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS09645	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS09670	COG1278	Cold shock
AKI39_RS09695	COG2814	Major facilitator Superfamily
AKI39_RS09700	COG1129	ABC transporter
AKI39_RS09720	COG0583	DNA-binding transcription factor activity
AKI39_RS09725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKI39_RS09740	COG4608	Belongs to the ABC transporter superfamily
AKI39_RS09745	COG0444	Belongs to the ABC transporter superfamily
AKI39_RS09750	COG0747	negative chemotaxis
AKI39_RS09775	COG0765	amino acid transport
AKI39_RS09780	COG0765	amino acid transport
AKI39_RS09785	COG1126	abc transporter atp-binding protein
AKI39_RS09790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKI39_RS09800	COG0656	L-ascorbic acid biosynthetic process
AKI39_RS09810	COG0477	Major facilitator Superfamily
AKI39_RS09815	COG0583	DNA-binding transcription factor activity
AKI39_RS09875	COG2951	lytic endotransglycosylase activity
AKI39_RS09910	COG0590	tRNA wobble adenosine to inosine editing
AKI39_RS09915	COG1619	proteins homologs of microcin C7 resistance protein MccF
AKI39_RS09920	COG4651	solute:proton antiporter activity
AKI39_RS09920	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AKI39_RS09930	COG0488	(ABC) transporter
AKI39_RS09945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKI39_RS09950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKI39_RS09970	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AKI39_RS09975	COG0667	Aldo Keto reductase
AKI39_RS09990	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AKI39_RS10045	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AKI39_RS10050	COG1414	Transcriptional regulator
AKI39_RS10070	COG1349	DNA-binding transcription factor activity
AKI39_RS10100	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AKI39_RS10110	COG0402	S-adenosylhomocysteine deaminase activity
AKI39_RS10125	COG0765	amino acid transport
AKI39_RS10130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKI39_RS10155	COG0583	DNA-binding transcription factor activity
AKI39_RS10160	COG0436	Aminotransferase
AKI39_RS10170	COG1538	Outer membrane efflux protein
AKI39_RS10180	COG2274	protein secretion by the type I secretion system
AKI39_RS10185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKI39_RS10190	COG2197	response regulator
AKI39_RS10215	COG2267	carboxylic ester hydrolase activity
AKI39_RS10220	COG0235	Class ii aldolase
AKI39_RS10240	COG3328	transposase activity
AKI39_RS10245	COG1609	Transcriptional regulator
AKI39_RS10250	COG0583	DNA-binding transcription factor activity
AKI39_RS10265	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS10275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKI39_RS10295	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS10315	COG0789	Transcriptional regulator
AKI39_RS10325	COG0789	Transcriptional regulator
AKI39_RS10330	COG2217	Heavy metal translocating P-type atpase
AKI39_RS10340	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AKI39_RS10340	COG0678	peroxiredoxin activity
AKI39_RS10375	COG0339	signal peptide processing
AKI39_RS10380	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AKI39_RS10385	COG4566	intracellular signal transduction
AKI39_RS10395	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AKI39_RS10400	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKI39_RS10405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKI39_RS10430	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
AKI39_RS10440	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AKI39_RS10455	COG1191	sigma factor activity
AKI39_RS10480	COG0745	RESPONSE REGULATOR receiver
AKI39_RS10490	COG0835	chemotaxis
AKI39_RS10495	COG0840	transmembrane signaling receptor activity
AKI39_RS10500	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AKI39_RS10505	COG2201	protein-glutamate methylesterase activity
AKI39_RS10510	COG0745	RESPONSE REGULATOR receiver
AKI39_RS10515	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AKI39_RS10520	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AKI39_RS10545	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
AKI39_RS10555	COG1558	bacterial-type flagellum-dependent cell motility
AKI39_RS10570	COG4787	bacterial-type flagellum-dependent cell motility
AKI39_RS10595	COG1256	bacterial-type flagellum assembly
AKI39_RS10600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AKI39_RS10605	COG0840	transmembrane signaling receptor activity
AKI39_RS10615	COG0840	transmembrane signaling receptor activity
AKI39_RS10640	COG3190	flagellar
AKI39_RS10645	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AKI39_RS10655	COG1580	Controls the rotational direction of flagella during chemotaxis
AKI39_RS10680	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AKI39_RS10690	COG1677	Flagellar hook-basal body complex protein FliE
AKI39_RS10695	COG3300	MHYT domain
AKI39_RS10695	COG5001	Diguanylate cyclase
AKI39_RS10705	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AKI39_RS10725	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AKI39_RS10730	COG1334	flagellar protein FlaG
AKI39_RS10735	COG0285	dihydrofolate synthase activity
AKI39_RS10765	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AKI39_RS10770	COG0024	Methionine aminopeptidase
AKI39_RS10775	COG0052	Belongs to the universal ribosomal protein uS2 family
AKI39_RS10780	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AKI39_RS10785	COG0528	UMP kinase activity
AKI39_RS10790	COG0233	cytoplasmic translational termination
AKI39_RS10795	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AKI39_RS10800	COG0575	Belongs to the CDS family
AKI39_RS10805	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AKI39_RS10810	COG0750	zinc metalloprotease
AKI39_RS10815	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AKI39_RS10825	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKI39_RS10830	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AKI39_RS10840	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AKI39_RS10845	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AKI39_RS10850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKI39_RS10865	COG2169	Transcriptional regulator
AKI39_RS10865	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AKI39_RS10870	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AKI39_RS10870	COG0519	Catalyzes the synthesis of GMP from XMP
AKI39_RS10890	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AKI39_RS10895	COG2867	negative regulation of translational initiation
AKI39_RS10905	COG1960	acyl-CoA dehydrogenase activity
AKI39_RS10910	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AKI39_RS10940	COG0411	ABC transporter
AKI39_RS10955	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AKI39_RS10975	COG2814	Major facilitator Superfamily
AKI39_RS10980	COG0697	spore germination
AKI39_RS10985	COG2363	Small membrane protein
AKI39_RS10995	COG0395	ABC-type sugar transport system, permease component
AKI39_RS11000	COG1116	anion transmembrane transporter activity
AKI39_RS11015	COG4974	Belongs to the 'phage' integrase family
AKI39_RS11025	COG0288	reversible hydration of carbon dioxide
AKI39_RS11030	COG1464	Belongs to the NlpA lipoprotein family
AKI39_RS11035	COG0628	permease
AKI39_RS11040	COG0735	belongs to the Fur family
AKI39_RS11045	COG0583	DNA-binding transcription factor activity
AKI39_RS11100	COG5285	phytanoyl-CoA dioxygenase
AKI39_RS11105	COG4178	(ABC) transporter
AKI39_RS11125	COG2900	Belongs to the SlyX family
AKI39_RS11140	COG2268	Band 7 protein
AKI39_RS11145	COG5564	TIM-barrel signal transduction protein
AKI39_RS11150	COG5441	Belongs to the UPF0261 family
AKI39_RS11175	COG0402	S-adenosylhomocysteine deaminase activity
AKI39_RS11200	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS11210	COG1012	belongs to the aldehyde dehydrogenase family
AKI39_RS11215	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS11220	COG0473	3-isopropylmalate dehydrogenase activity
AKI39_RS11230	COG1538	Outer membrane efflux protein
AKI39_RS11250	COG0583	DNA-binding transcription factor activity
AKI39_RS11260	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS11270	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS11285	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS11295	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AKI39_RS11335	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AKI39_RS11335	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AKI39_RS11365	COG0583	DNA-binding transcription factor activity
AKI39_RS11370	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AKI39_RS11375	COG0066	3-isopropylmalate dehydratase activity
AKI39_RS11400	COG0583	DNA-binding transcription factor activity
AKI39_RS11425	COG0432	Pfam Uncharacterised protein family UPF0047
AKI39_RS11450	COG3976	FMN-binding domain protein
AKI39_RS11450	COG1053	succinate dehydrogenase
AKI39_RS11480	COG0583	DNA-binding transcription factor activity
AKI39_RS11490	COG0318	PFAM AMP-dependent synthetase and ligase
AKI39_RS11495	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AKI39_RS11500	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AKI39_RS11530	COG3473	Maleate cis-trans isomerase
AKI39_RS11535	COG0596	Alpha beta hydrolase
AKI39_RS11540	COG2309	aminopeptidase activity
AKI39_RS11545	COG1335	isochorismatase
AKI39_RS11570	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AKI39_RS11595	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AKI39_RS11600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKI39_RS11615	COG0243	molybdopterin cofactor binding
AKI39_RS11620	COG0437	4 iron, 4 sulfur cluster binding
AKI39_RS11625	COG3302	dmso reductase anchor subunit
AKI39_RS11635	COG0697	spore germination
AKI39_RS11650	COG0436	Aminotransferase
AKI39_RS11655	COG0165	Argininosuccinate lyase
AKI39_RS11670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKI39_RS11675	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AKI39_RS11690	COG0318	PFAM AMP-dependent synthetase and ligase
AKI39_RS11705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AKI39_RS11710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKI39_RS11740	COG0640	Transcriptional regulator
AKI39_RS11760	COG3604	Transcriptional regulator
AKI39_RS11785	COG2205	protein histidine kinase activity
AKI39_RS11800	COG0784	Response regulator, receiver
AKI39_RS11805	COG4251	negative regulation of phosphorylation
AKI39_RS11835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKI39_RS11845	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS11850	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS11865	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AKI39_RS11865	COG3008	intermembrane lipid transfer
AKI39_RS11880	COG2188	Transcriptional regulator
AKI39_RS11890	COG3119	arylsulfatase activity
AKI39_RS11895	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS11905	COG3550	peptidyl-serine autophosphorylation
AKI39_RS11925	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKI39_RS11930	COG2159	amidohydrolase
AKI39_RS11940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AKI39_RS11945	COG2186	Transcriptional regulator
AKI39_RS11950	COG1024	Enoyl-CoA hydratase
AKI39_RS11960	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS11965	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS11975	COG1301	dicarboxylic acid transport
AKI39_RS11980	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS11990	COG0583	DNA-binding transcription factor activity
AKI39_RS12020	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS12045	COG0492	ferredoxin-NADP+ reductase activity
AKI39_RS12050	COG2423	ornithine cyclodeaminase activity
AKI39_RS12055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKI39_RS12085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKI39_RS12110	COG2985	domain, Protein
AKI39_RS12200	COG0583	DNA-binding transcription factor activity
AKI39_RS12215	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKI39_RS12220	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKI39_RS12225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AKI39_RS12235	COG1595	DNA-templated transcription, initiation
AKI39_RS12275	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS12280	COG0583	DNA-binding transcription factor activity
AKI39_RS12290	COG1285	pathogenesis
AKI39_RS12330	COG0702	epimerase
AKI39_RS12345	COG1132	(ABC) transporter
AKI39_RS12365	COG0589	response to stress
AKI39_RS12370	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
AKI39_RS12375	COG1609	Transcriptional regulator
AKI39_RS12385	COG1175	transmembrane transport
AKI39_RS12395	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AKI39_RS12400	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AKI39_RS12420	COG1609	Transcriptional regulator
AKI39_RS12430	COG1175	transmembrane transport
AKI39_RS12435	COG0395	ABC-type sugar transport system, permease component
AKI39_RS12440	COG3842	ATPase activity
AKI39_RS12450	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AKI39_RS12480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKI39_RS12505	COG0765	amino acid transport
AKI39_RS12510	COG1126	abc transporter atp-binding protein
AKI39_RS12520	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AKI39_RS12525	COG0583	DNA-binding transcription factor activity
AKI39_RS12535	COG1802	Transcriptional regulator
AKI39_RS12540	COG0277	FAD linked oxidase domain protein
AKI39_RS12540	COG0247	lactate metabolic process
AKI39_RS12560	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AKI39_RS12570	COG1396	sequence-specific DNA binding
AKI39_RS12575	COG2259	Doxx family
AKI39_RS12585	COG3064	Membrane
AKI39_RS12595	COG0583	DNA-binding transcription factor activity
AKI39_RS12605	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AKI39_RS12610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AKI39_RS12645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKI39_RS12650	COG0765	amino acid transport
AKI39_RS12660	COG2188	Transcriptional regulator
AKI39_RS12665	COG2986	histidine ammonia-lyase
AKI39_RS12710	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS12775	COG1024	Enoyl-CoA hydratase
AKI39_RS12785	COG1960	acyl-CoA dehydrogenase activity
AKI39_RS12790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AKI39_RS12805	COG1309	transcriptional regulator
AKI39_RS12825	COG1595	DNA-templated transcription, initiation
AKI39_RS12840	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKI39_RS12850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKI39_RS12855	COG0318	PFAM AMP-dependent synthetase and ligase
AKI39_RS12860	COG1024	Enoyl-CoA hydratase
AKI39_RS12870	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AKI39_RS12885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AKI39_RS12900	COG1414	Transcriptional regulator
AKI39_RS12905	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS12910	COG1228	amidohydrolase
AKI39_RS12935	COG0784	Response regulator, receiver
AKI39_RS12935	COG4191	Histidine kinase
AKI39_RS12945	COG0583	DNA-binding transcription factor activity
AKI39_RS12950	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AKI39_RS12960	COG3842	ATPase activity
AKI39_RS12970	COG1177	transmembrane transport
AKI39_RS12975	COG0024	Methionine aminopeptidase
AKI39_RS12990	COG0625	glutathione transferase activity
AKI39_RS13000	COG0583	DNA-binding transcription factor activity
AKI39_RS13005	COG1960	acyl-CoA dehydrogenase activity
AKI39_RS13010	COG4948	Mandelate Racemase Muconate Lactonizing
AKI39_RS13020	COG0583	DNA-binding transcription factor activity
AKI39_RS13045	COG3278	Belongs to the heme-copper respiratory oxidase family
AKI39_RS13060	COG2010	Cytochrome c
AKI39_RS13065	COG0348	domain, Protein
AKI39_RS13075	COG2197	response regulator
AKI39_RS13085	COG0784	Response regulator, receiver
AKI39_RS13095	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS13125	COG0589	response to stress
AKI39_RS13135	COG0589	response to stress
AKI39_RS13150	COG0693	protein deglycase activity
AKI39_RS13155	COG4106	trans-aconitate 2-methyltransferase activity
AKI39_RS13165	COG3119	arylsulfatase activity
AKI39_RS13190	COG3842	ATPase activity
AKI39_RS13230	COG1278	Cold shock
AKI39_RS13240	COG2188	Transcriptional regulator
AKI39_RS13265	COG4948	Mandelate Racemase Muconate Lactonizing
AKI39_RS13285	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS13295	COG1802	Transcriptional regulator
AKI39_RS13305	COG4948	Mandelate Racemase Muconate Lactonizing
AKI39_RS13315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKI39_RS13320	COG4948	Mandelate Racemase Muconate Lactonizing
AKI39_RS13325	COG0583	DNA-binding transcription factor activity
AKI39_RS13340	COG0443	Heat shock 70 kDa protein
AKI39_RS13400	COG0437	4 iron, 4 sulfur cluster binding
AKI39_RS13415	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS13440	COG0583	DNA-binding transcription factor activity
AKI39_RS13450	COG4948	Mandelate Racemase Muconate Lactonizing
AKI39_RS13460	COG1960	acyl-CoA dehydrogenase activity
AKI39_RS13470	COG1024	Enoyl-CoA hydratase
AKI39_RS13490	COG2301	Belongs to the HpcH HpaI aldolase family
AKI39_RS13495	COG0318	PFAM AMP-dependent synthetase and ligase
AKI39_RS13505	COG0583	DNA-binding transcription factor activity
AKI39_RS13510	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS13520	COG0747	negative chemotaxis
AKI39_RS13560	COG0444	Belongs to the ABC transporter superfamily
AKI39_RS13585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKI39_RS13590	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS13605	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AKI39_RS13620	COG4521	taurine ABC transporter
AKI39_RS13625	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AKI39_RS13630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKI39_RS13635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKI39_RS13640	COG0477	Major facilitator Superfamily
AKI39_RS13645	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AKI39_RS13650	COG1414	Transcriptional regulator
AKI39_RS13685	COG1414	Transcriptional regulator
AKI39_RS13690	COG1414	Transcriptional regulator
AKI39_RS13695	COG1012	belongs to the aldehyde dehydrogenase family
AKI39_RS13700	COG0318	PFAM AMP-dependent synthetase and ligase
AKI39_RS13705	COG2271	Major facilitator Superfamily
AKI39_RS13715	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AKI39_RS13730	COG0628	permease
AKI39_RS13740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKI39_RS13755	COG2070	2-Nitropropane dioxygenase
AKI39_RS13765	COG1454	alcohol dehydrogenase
AKI39_RS13775	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AKI39_RS13795	COG0583	DNA-binding transcription factor activity
AKI39_RS13800	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AKI39_RS13835	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS13840	COG4948	Mandelate Racemase Muconate Lactonizing
AKI39_RS13850	COG1840	ABC-type Fe3 transport system, periplasmic component
AKI39_RS13855	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AKI39_RS13860	COG3842	ATPase activity
AKI39_RS13865	COG1446	asparaginase
AKI39_RS13875	COG1741	Belongs to the pirin family
AKI39_RS13880	COG1741	Belongs to the pirin family
AKI39_RS13885	COG0583	DNA-binding transcription factor activity
AKI39_RS13890	COG2204	response regulator
AKI39_RS13900	COG0174	glutamine synthetase
AKI39_RS13905	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AKI39_RS13910	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AKI39_RS13915	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AKI39_RS13920	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AKI39_RS13925	COG1561	YicC-like family, N-terminal region
AKI39_RS13930	COG2304	oxidoreductase activity
AKI39_RS13940	COG0714	Associated with various cellular activities
AKI39_RS13945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKI39_RS13950	COG2304	oxidoreductase activity
AKI39_RS13955	COG3781	membrane
AKI39_RS13965	COG4771	TonB-dependent receptor
AKI39_RS13970	COG0791	NLP P60 protein
AKI39_RS13975	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS13980	COG0194	GDP metabolic process
AKI39_RS13985	COG1758	RNA polymerase activity
AKI39_RS13990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AKI39_RS14000	COG1126	abc transporter atp-binding protein
AKI39_RS14005	COG0765	amino acid transport
AKI39_RS14010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKI39_RS14030	COG0084	hydrolase, TatD family'
AKI39_RS14035	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AKI39_RS14040	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AKI39_RS14045	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AKI39_RS14060	COG1653	transport
AKI39_RS14065	COG1175	transmembrane transport
AKI39_RS14070	COG0395	ABC-type sugar transport system, permease component
AKI39_RS14075	COG3842	ATPase activity
AKI39_RS14110	COG1393	Belongs to the ArsC family
AKI39_RS14115	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AKI39_RS14125	COG0386	Belongs to the glutathione peroxidase family
AKI39_RS14140	COG0154	amidase activity
AKI39_RS14160	COG2814	Major facilitator Superfamily
AKI39_RS14170	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AKI39_RS14190	COG0095	Lipoate-protein ligase
AKI39_RS14200	COG1012	belongs to the aldehyde dehydrogenase family
AKI39_RS14240	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AKI39_RS14245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKI39_RS14255	COG1309	transcriptional regulator
AKI39_RS14265	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AKI39_RS14295	COG4336	lyase activity
AKI39_RS14320	COG4181	ATPase activity
AKI39_RS14330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKI39_RS14335	COG0584	glycerophosphoryl diester phosphodiesterase
AKI39_RS14340	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AKI39_RS14360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKI39_RS14375	COG1522	sequence-specific DNA binding
AKI39_RS14380	COG1187	pseudouridine synthase activity
AKI39_RS14405	COG3161	chorismate lyase activity
AKI39_RS14415	COG4172	Belongs to the ABC transporter superfamily
AKI39_RS14420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKI39_RS14425	COG0601	transmembrane transport
AKI39_RS14445	COG2154	pterin-4-alpha-carbinolamine dehydratase
AKI39_RS14460	COG0165	Argininosuccinate lyase
AKI39_RS14465	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKI39_RS14490	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AKI39_RS14495	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AKI39_RS14500	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AKI39_RS14505	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AKI39_RS14510	COG2252	PERMEase
AKI39_RS14515	COG0602	queuosine metabolic process
AKI39_RS14520	COG0720	synthase
AKI39_RS14525	COG3655	Transcriptional regulator
AKI39_RS14540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKI39_RS14555	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS14560	COG2814	Major facilitator Superfamily
AKI39_RS14565	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS14570	COG1228	amidohydrolase
AKI39_RS14580	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AKI39_RS14635	COG3541	Predicted nucleotidyltransferase
AKI39_RS14700	COG1793	dna ligase
AKI39_RS14705	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AKI39_RS14705	COG1793	dna ligase
AKI39_RS14710	COG0297	glycogen (starch) synthase activity
AKI39_RS14715	COG0366	Alpha amylase catalytic
AKI39_RS14725	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AKI39_RS14735	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AKI39_RS14740	COG1640	4-alpha-glucanotransferase
AKI39_RS14755	COG1289	transmembrane transporter activity
AKI39_RS14765	COG1566	PFAM secretion protein HlyD family protein
AKI39_RS14770	COG1538	Outer membrane efflux protein
AKI39_RS14775	COG0400	carboxylic ester hydrolase activity
AKI39_RS14800	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS14830	COG1136	(ABC) transporter
AKI39_RS14845	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AKI39_RS14850	COG1802	Transcriptional regulator
AKI39_RS14860	COG3246	L-lysine catabolic process to acetate
AKI39_RS14870	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS14880	COG0559	Belongs to the binding-protein-dependent transport system permease family
AKI39_RS14905	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKI39_RS14910	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AKI39_RS14915	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS14935	COG0395	ABC-type sugar transport system, permease component
AKI39_RS14945	COG3842	ATPase activity
AKI39_RS14950	COG3842	ATPase activity
AKI39_RS14975	COG0477	Major facilitator Superfamily
AKI39_RS15000	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKI39_RS15005	COG2807	transmembrane transport
AKI39_RS15010	COG2207	Transcriptional regulator
AKI39_RS15020	COG0583	DNA-binding transcription factor activity
AKI39_RS15025	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS15035	COG0583	DNA-binding transcription factor activity
AKI39_RS15040	COG0667	Aldo Keto reductase
AKI39_RS15045	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS15050	COG0640	Transcriptional regulator
AKI39_RS15065	COG2814	Major facilitator Superfamily
AKI39_RS15075	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AKI39_RS15090	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKI39_RS15115	COG1879	ABC-type sugar transport system periplasmic component
AKI39_RS15120	COG1172	Belongs to the binding-protein-dependent transport system permease family
AKI39_RS15125	COG1129	ABC transporter
AKI39_RS15130	COG1802	Transcriptional regulator
AKI39_RS15135	COG1454	alcohol dehydrogenase
AKI39_RS15155	COG0523	cobalamin synthesis protein
AKI39_RS15185	COG4977	sequence-specific DNA binding
AKI39_RS15195	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS15215	COG3119	arylsulfatase activity
AKI39_RS15245	COG2267	carboxylic ester hydrolase activity
AKI39_RS15250	COG0519	Catalyzes the synthesis of GMP from XMP
AKI39_RS15250	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AKI39_RS15260	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AKI39_RS15280	COG0047	phosphoribosylformylglycinamidine synthase activity
AKI39_RS15280	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AKI39_RS15290	COG0613	PHP domain protein
AKI39_RS15310	COG0084	hydrolase, TatD family'
AKI39_RS15315	COG1136	(ABC) transporter
AKI39_RS15330	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AKI39_RS15340	COG2271	Major facilitator Superfamily
AKI39_RS15345	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS15350	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AKI39_RS15355	COG1803	Methylglyoxal synthase
AKI39_RS15365	COG0633	Ferredoxin
AKI39_RS15370	COG0443	Heat shock 70 kDa protein
AKI39_RS15375	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AKI39_RS15380	COG0316	Belongs to the HesB IscA family
AKI39_RS15385	COG0822	iron-sulfur transferase activity
AKI39_RS15390	COG1104	cysteine desulfurase activity
AKI39_RS15400	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKI39_RS15405	COG0556	nucleotide-excision repair
AKI39_RS15415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AKI39_RS15420	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AKI39_RS15425	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AKI39_RS15430	COG0740	serine-type endopeptidase activity
AKI39_RS15435	COG0544	peptidyl-prolyl cis-trans isomerase activity
AKI39_RS15445	COG1278	Cold shock
AKI39_RS15460	COG2171	N-acyltransferase activity
AKI39_RS15470	COG2890	protein-(glutamine-N5) methyltransferase activity
AKI39_RS15475	COG0488	(ABC) transporter
AKI39_RS15480	COG0210	DNA helicase
AKI39_RS15495	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AKI39_RS15495	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AKI39_RS15500	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AKI39_RS15505	COG0196	riboflavin kinase activity
AKI39_RS15510	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AKI39_RS15515	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AKI39_RS15520	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AKI39_RS15535	COG0756	dUTP diphosphatase activity
AKI39_RS15540	COG1902	pentaerythritol trinitrate reductase activity
AKI39_RS15545	COG1764	response to oxidative stress
AKI39_RS15550	COG1914	H( )-stimulated, divalent metal cation uptake system
AKI39_RS15580	COG0506	proline dehydrogenase activity
AKI39_RS15580	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AKI39_RS15580	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AKI39_RS15590	COG3008	intermembrane lipid transfer
AKI39_RS15595	COG2995	paraquat-inducible protein a
AKI39_RS15600	COG0542	response to heat
AKI39_RS15605	COG4953	penicillin-binding protein 1C
AKI39_RS15615	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AKI39_RS15620	COG1278	Cold shock
AKI39_RS15630	COG0183	Belongs to the thiolase family
AKI39_RS15640	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AKI39_RS15650	COG0811	peptide transport
AKI39_RS15655	COG0848	biopolymer transport protein
AKI39_RS15665	COG2835	tetraacyldisaccharide 4'-kinase activity
AKI39_RS15675	COG0563	adenylate kinase activity
AKI39_RS15685	COG0728	peptidoglycan biosynthetic process
AKI39_RS15695	COG0268	Binds directly to 16S ribosomal RNA
AKI39_RS15700	COG3836	Belongs to the HpcH HpaI aldolase family
AKI39_RS15715	COG2186	Transcriptional regulator
AKI39_RS15730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AKI39_RS15740	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AKI39_RS15750	COG0154	amidase activity
AKI39_RS15755	COG2814	Major facilitator Superfamily
AKI39_RS15765	COG3158	transport of potassium into the cell
AKI39_RS15770	COG0642	Histidine kinase
AKI39_RS15800	COG0776	regulation of translation
AKI39_RS15805	COG3128	pkhd-type hydroxylase
AKI39_RS15810	COG2873	o-acetylhomoserine
AKI39_RS15815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKI39_RS15820	COG0557	exoribonuclease II activity
AKI39_RS15845	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AKI39_RS15855	COG0069	glutamate synthase activity
AKI39_RS15865	COG2204	response regulator
AKI39_RS15870	COG2204	response regulator
AKI39_RS15880	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AKI39_RS15895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKI39_RS15915	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AKI39_RS15920	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AKI39_RS15940	COG1278	Cold shock
AKI39_RS15965	COG0625	glutathione transferase activity
AKI39_RS15970	COG0730	response to heat
AKI39_RS15975	COG0482	sulfurtransferase activity
AKI39_RS15995	COG0247	lactate metabolic process
AKI39_RS16000	COG0277	FAD linked oxidase domain protein
AKI39_RS16005	COG0277	FAD linked oxidase domain protein
AKI39_RS16010	COG0277	FAD linked oxidase domain protein
AKI39_RS16015	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AKI39_RS16020	COG0312	modulator of DNA gyrase
AKI39_RS16040	COG0308	aminopeptidase N
AKI39_RS16045	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AKI39_RS16065	COG1846	Transcriptional regulator
AKI39_RS16075	COG1566	PFAM secretion protein HlyD family protein
AKI39_RS16080	COG2814	Major facilitator Superfamily
AKI39_RS16090	COG0473	3-isopropylmalate dehydrogenase activity
AKI39_RS16095	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AKI39_RS16100	COG0433	COG0433 Predicted ATPase
AKI39_RS16105	COG0217	transcriptional regulatory protein
AKI39_RS16110	COG0151	Belongs to the GarS family
AKI39_RS16120	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AKI39_RS16125	COG0799	negative regulation of ribosome biogenesis
AKI39_RS16130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AKI39_RS16135	COG0424	maF-like protein
AKI39_RS16140	COG1301	dicarboxylic acid transport
AKI39_RS16195	COG1132	(ABC) transporter
AKI39_RS16215	COG0726	polysaccharide deacetylase
AKI39_RS16220	COG0438	transferase activity, transferring glycosyl groups
AKI39_RS16230	COG0726	polysaccharide deacetylase
AKI39_RS16235	COG0438	transferase activity, transferring glycosyl groups
AKI39_RS16255	COG1643	Atp-dependent helicase
AKI39_RS16270	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AKI39_RS16270	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AKI39_RS16275	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AKI39_RS16280	COG0704	Plays a role in the regulation of phosphate uptake
AKI39_RS16285	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AKI39_RS16300	COG1393	Belongs to the ArsC family
AKI39_RS16305	COG1177	transmembrane transport
AKI39_RS16310	COG1176	ABC-type spermidine putrescine transport system, permease component I
AKI39_RS16315	COG3842	ATPase activity
AKI39_RS16320	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AKI39_RS16325	COG3642	lipopolysaccharide core region biosynthetic process
AKI39_RS16330	COG2346	COG2346, Truncated hemoglobins
AKI39_RS16335	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AKI39_RS16350	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS16370	COG0583	DNA-binding transcription factor activity
AKI39_RS16380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AKI39_RS16395	COG3618	amidohydrolase
AKI39_RS16400	COG0583	DNA-binding transcription factor activity
AKI39_RS16410	COG1960	acyl-CoA dehydrogenase activity
AKI39_RS16415	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AKI39_RS16430	COG1960	acyl-CoA dehydrogenase activity
AKI39_RS16445	COG1024	Enoyl-CoA hydratase
AKI39_RS16450	COG1802	Transcriptional regulator
AKI39_RS16460	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AKI39_RS16465	COG1562	ergosterol biosynthetic process
AKI39_RS16470	COG1562	ergosterol biosynthetic process
AKI39_RS16480	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AKI39_RS16490	COG1131	(ABC) transporter
AKI39_RS16495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AKI39_RS16510	COG0436	Aminotransferase
AKI39_RS16515	COG3737	Protein of unknown function (DUF498/DUF598)
AKI39_RS16520	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AKI39_RS16525	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AKI39_RS16530	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AKI39_RS16550	COG4774	siderophore transport
AKI39_RS16560	COG0305	Participates in initiation and elongation during chromosome replication
AKI39_RS16570	COG0359	binds to the 23S rRNA
AKI39_RS16575	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AKI39_RS16580	COG2965	DNA replication, synthesis of RNA primer
AKI39_RS16585	COG0360	Binds together with S18 to 16S ribosomal RNA
AKI39_RS16590	COG1469	GTP cyclohydrolase I activity
AKI39_RS16600	COG0142	geranyltranstransferase activity
AKI39_RS16605	COG1722	exodeoxyribonuclease VII activity
AKI39_RS16630	COG0501	Belongs to the peptidase M48B family
AKI39_RS16635	COG1760	l-serine dehydratase
AKI39_RS16650	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AKI39_RS16650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AKI39_RS16665	COG0831	urea catabolic process
AKI39_RS16675	COG0832	Belongs to the urease beta subunit family
AKI39_RS16685	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AKI39_RS16695	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AKI39_RS16705	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS16715	COG1217	gtp-binding protein TYPA
AKI39_RS16720	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AKI39_RS16725	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AKI39_RS16730	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AKI39_RS16735	COG2251	uridine kinase activity
AKI39_RS16735	COG0195	Participates in both transcription termination and antitermination
AKI39_RS16740	COG0779	Required for maturation of 30S ribosomal subunits
AKI39_RS16745	COG1187	pseudouridine synthase activity
AKI39_RS16750	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AKI39_RS16760	COG0523	cobalamin synthesis protein
AKI39_RS16775	COG1116	anion transmembrane transporter activity
AKI39_RS16780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKI39_RS16785	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS16790	COG0179	Fumarylacetoacetate (FAA) hydrolase
AKI39_RS16800	COG3386	PFAM SMP-30 Gluconolaconase
AKI39_RS16805	COG0583	DNA-binding transcription factor activity
AKI39_RS16815	COG2814	Major facilitator Superfamily
AKI39_RS16845	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AKI39_RS16850	COG0582	viral genome integration into host DNA
AKI39_RS16890	COG1546	Belongs to the CinA family
AKI39_RS16890	COG1058	Belongs to the CinA family
AKI39_RS16900	COG2188	Transcriptional regulator
AKI39_RS16905	COG2084	Dehydrogenase
AKI39_RS16915	COG2721	sulfolactate sulfo-lyase activity
AKI39_RS16920	COG0625	glutathione transferase activity
AKI39_RS16925	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AKI39_RS16930	COG1047	Peptidyl-prolyl cis-trans
AKI39_RS16950	COG0534	Mate efflux family protein
AKI39_RS16960	COG2050	protein possibly involved in aromatic compounds catabolism
AKI39_RS16965	COG1024	Enoyl-CoA hydratase
AKI39_RS16970	COG1012	belongs to the aldehyde dehydrogenase family
AKI39_RS16975	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AKI39_RS16980	COG2151	metal-sulfur cluster biosynthetic enzyme
AKI39_RS16985	COG3396	Phenylacetate-CoA oxygenase
AKI39_RS16990	COG3460	Phenylacetate-CoA oxygenase
AKI39_RS16995	COG3396	Phenylacetate-CoA oxygenase
AKI39_RS17000	COG3327	negative regulation of DNA-templated transcription, initiation
AKI39_RS17005	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AKI39_RS17010	COG0501	Belongs to the peptidase M48B family
AKI39_RS17015	COG1162	GTPase activity
AKI39_RS17025	COG0335	large ribosomal subunit rRNA binding
AKI39_RS17050	COG0175	sulfate reduction
AKI39_RS17055	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AKI39_RS17060	COG4208	sulfate ABC transporter
AKI39_RS17070	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AKI39_RS17075	COG0450	alkyl hydroperoxide reductase
AKI39_RS17080	COG1960	acyl-CoA dehydrogenase activity
AKI39_RS17095	COG0123	including yeast histone deacetylase and acetoin utilization protein
AKI39_RS17100	COG2951	lytic endotransglycosylase activity
AKI39_RS17110	COG1555	photosystem II stabilization
AKI39_RS17110	COG1596	polysaccharide export
AKI39_RS17115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKI39_RS17120	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AKI39_RS17125	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AKI39_RS17145	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AKI39_RS17150	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AKI39_RS17160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AKI39_RS17165	COG1605	Chorismate mutase
AKI39_RS17165	COG0077	Prephenate dehydratase
AKI39_RS17170	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AKI39_RS17185	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AKI39_RS17205	COG0596	Alpha beta hydrolase
AKI39_RS17215	COG2897	thiosulfate sulfurtransferase activity
AKI39_RS17220	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS17240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKI39_RS17240	COG3453	Protein conserved in bacteria
AKI39_RS17245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AKI39_RS17250	COG2207	Transcriptional regulator
AKI39_RS17255	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS17265	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AKI39_RS17270	COG2318	DinB family
AKI39_RS17275	COG2721	sulfolactate sulfo-lyase activity
AKI39_RS17280	COG2721	sulfolactate sulfo-lyase activity
AKI39_RS17290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKI39_RS17295	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AKI39_RS17305	COG2833	Protein of unknown function (DUF455)
AKI39_RS17315	COG0840	transmembrane signaling receptor activity
AKI39_RS17340	COG2201	protein-glutamate methylesterase activity
AKI39_RS17345	COG2203	Gaf domain
AKI39_RS17345	COG4251	negative regulation of phosphorylation
AKI39_RS17345	COG3706	GGDEF domain
AKI39_RS17345	COG5001	Diguanylate cyclase
AKI39_RS17350	COG1802	Transcriptional regulator
AKI39_RS17360	COG4948	Mandelate Racemase Muconate Lactonizing
AKI39_RS17365	COG0246	Mannitol dehydrogenase
AKI39_RS17375	COG1132	(ABC) transporter
AKI39_RS17380	COG0189	ligase activity
AKI39_RS17380	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AKI39_RS17385	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AKI39_RS17385	COG0189	ligase activity
AKI39_RS17395	COG2823	Periplasmic or secreted lipoprotein
AKI39_RS17415	COG0672	)-iron permease
AKI39_RS17430	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
AKI39_RS17435	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS17440	COG3243	poly(R)-hydroxyalkanoic acid synthase
AKI39_RS17450	COG0564	pseudouridine synthase activity
AKI39_RS17460	COG1199	ATP-dependent helicase activity
AKI39_RS17465	COG2183	response to ionizing radiation
AKI39_RS17485	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AKI39_RS17490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKI39_RS17495	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKI39_RS17500	COG0567	Dehydrogenase, E1 component
AKI39_RS17505	COG0281	malic enzyme
AKI39_RS17505	COG0280	phosphate acetyltransferase
AKI39_RS17540	COG0372	Belongs to the citrate synthase family
AKI39_RS17545	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AKI39_RS17550	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AKI39_RS17555	COG1053	succinate dehydrogenase
AKI39_RS17560	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AKI39_RS17565	COG2009	succinate dehydrogenase
AKI39_RS17570	COG2188	Transcriptional regulator
AKI39_RS17585	COG0039	L-malate dehydrogenase activity
AKI39_RS17595	COG2079	MmgE PrpD family protein
AKI39_RS17610	COG0625	glutathione transferase activity
AKI39_RS17615	COG0625	glutathione transferase activity
AKI39_RS17625	COG0477	Major facilitator Superfamily
AKI39_RS17685	COG1176	ABC-type spermidine putrescine transport system, permease component I
AKI39_RS17690	COG3842	ATPase activity
AKI39_RS17705	COG1196	nuclear chromosome segregation
AKI39_RS17705	COG3264	Mechanosensitive ion channel
AKI39_RS17750	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKI39_RS17795	COG4126	flavin adenine dinucleotide binding
AKI39_RS17825	COG1268	BioY protein
AKI39_RS17830	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AKI39_RS17835	COG1122	ATPase activity
AKI39_RS17840	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKI39_RS17845	COG2917	probably involved in intracellular septation
AKI39_RS17855	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKI39_RS17860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKI39_RS17870	COG1196	nuclear chromosome segregation
AKI39_RS17875	COG0477	Major facilitator Superfamily
AKI39_RS17880	COG1573	uracil-dna glycosylase
AKI39_RS17885	COG1214	PFAM Peptidase M22, glycoprotease
AKI39_RS17900	COG0450	alkyl hydroperoxide reductase
AKI39_RS17905	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKI39_RS17910	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AKI39_RS17915	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AKI39_RS17920	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AKI39_RS17925	COG0560	Phosphoserine phosphatase
AKI39_RS17935	COG4774	siderophore transport
AKI39_RS17950	COG1007	ATP synthesis coupled electron transport
AKI39_RS17965	COG0713	ATP synthesis coupled electron transport
AKI39_RS17975	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AKI39_RS17980	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AKI39_RS17985	COG1034	ATP synthesis coupled electron transport
AKI39_RS17985	COG1034	ATP synthesis coupled electron transport
AKI39_RS17995	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AKI39_RS18000	COG0649	NAD binding
AKI39_RS18005	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AKI39_RS18010	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AKI39_RS18015	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AKI39_RS18020	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AKI39_RS18025	COG0405	Gamma-glutamyltransferase
AKI39_RS18035	COG0583	DNA-binding transcription factor activity
AKI39_RS18045	COG2133	pyrroloquinoline quinone binding
AKI39_RS18055	COG0668	transmembrane transport
AKI39_RS18065	COG2204	response regulator
AKI39_RS18085	COG0583	DNA-binding transcription factor activity
AKI39_RS18090	COG1064	alcohol dehydrogenase
AKI39_RS18095	COG0500	methyltransferase
AKI39_RS18100	COG3265	gluconokinase activity
AKI39_RS18115	COG0477	Major facilitator Superfamily
AKI39_RS18120	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS18125	COG3842	ATPase activity
AKI39_RS18135	COG1178	ABC-type Fe3 transport system permease component
AKI39_RS18140	COG2186	Transcriptional regulator
AKI39_RS18145	COG2079	MmgE PrpD family protein
AKI39_RS18150	COG0473	3-isopropylmalate dehydrogenase activity
AKI39_RS18160	COG2814	Major facilitator Superfamily
AKI39_RS18165	COG0583	DNA-binding transcription factor activity
AKI39_RS18180	COG3220	belongs to the UPF0276 family
AKI39_RS18200	COG1595	DNA-templated transcription, initiation
AKI39_RS18205	COG4944	Protein of unknown function (DUF1109)
AKI39_RS18210	COG3685	Protein conserved in bacteria
AKI39_RS18215	COG3546	catalase activity
AKI39_RS18245	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS18250	COG2116	formate transmembrane transporter activity
AKI39_RS18265	COG2814	Major facilitator Superfamily
AKI39_RS18275	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AKI39_RS18275	COG3008	intermembrane lipid transfer
AKI39_RS18280	COG2995	paraquat-inducible protein a
AKI39_RS18300	COG4191	Histidine kinase
AKI39_RS18315	COG0154	amidase activity
AKI39_RS18325	COG0583	DNA-binding transcription factor activity
AKI39_RS18330	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AKI39_RS18335	COG0149	triose-phosphate isomerase activity
AKI39_RS18355	COG0028	Belongs to the TPP enzyme family
AKI39_RS18360	COG4948	Mandelate Racemase Muconate Lactonizing
AKI39_RS18380	COG0300	oxidoreductase activity
AKI39_RS18385	COG3387	PFAM Glycoside hydrolase 15-related
AKI39_RS18395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKI39_RS18410	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AKI39_RS18420	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AKI39_RS18440	COG2423	ornithine cyclodeaminase activity
AKI39_RS18445	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS18450	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AKI39_RS18465	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AKI39_RS18475	COG1185	polyribonucleotide nucleotidyltransferase activity
AKI39_RS18480	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AKI39_RS18490	COG1183	phosphatidylcholine synthase activity
AKI39_RS18495	COG0688	phosphatidylethanolamine metabolic process
AKI39_RS18500	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AKI39_RS18505	COG0440	acetolactate synthase activity
AKI39_RS18510	COG0028	Belongs to the TPP enzyme family
AKI39_RS18515	COG1289	transmembrane transporter activity
AKI39_RS18520	COG3022	response to hydroperoxide
AKI39_RS18525	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS18550	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS18565	COG0798	PFAM Bile acid sodium symporter
AKI39_RS18570	COG0431	NADPH-dependent FMN reductase
AKI39_RS18600	COG1252	NADH dehydrogenase
AKI39_RS18610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKI39_RS18615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKI39_RS18620	COG0477	Major facilitator Superfamily
AKI39_RS18625	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AKI39_RS18630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AKI39_RS18635	COG1845	cytochrome c oxidase, subunit III
AKI39_RS18640	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AKI39_RS18655	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AKI39_RS18660	COG2207	Transcriptional regulator
AKI39_RS18665	COG0667	Aldo Keto reductase
AKI39_RS18675	COG2197	response regulator
AKI39_RS18680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKI39_RS18680	COG2205	protein histidine kinase activity
AKI39_RS18690	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AKI39_RS18695	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AKI39_RS18705	COG1271	oxidase subunit
AKI39_RS18710	COG1294	oxidase, subunit
AKI39_RS18730	COG2188	Transcriptional regulator
AKI39_RS18745	COG1309	transcriptional regulator
AKI39_RS18750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKI39_RS18755	COG0179	Fumarylacetoacetate (FAA) hydrolase
AKI39_RS18765	COG2080	2 iron, 2 sulfur cluster binding
AKI39_RS18770	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AKI39_RS18770	COG2010	Cytochrome c
AKI39_RS18795	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AKI39_RS18800	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AKI39_RS18810	COG0747	negative chemotaxis
AKI39_RS18815	COG0601	transmembrane transport
AKI39_RS18835	COG1737	Transcriptional regulator
AKI39_RS18840	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AKI39_RS18850	COG0583	DNA-binding transcription factor activity
AKI39_RS18855	COG1960	acyl-CoA dehydrogenase activity
AKI39_RS18870	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AKI39_RS18875	COG1674	ftsk spoiiie
AKI39_RS18880	COG0492	ferredoxin-NADP+ reductase activity
AKI39_RS18885	COG1193	negative regulation of DNA recombination
AKI39_RS18895	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKI39_RS18910	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AKI39_RS18915	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AKI39_RS18920	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AKI39_RS18925	COG2205	protein histidine kinase activity
AKI39_RS18935	COG0745	RESPONSE REGULATOR receiver
AKI39_RS18975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AKI39_RS18995	COG0612	Peptidase, M16
AKI39_RS19000	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AKI39_RS19000	COG2010	Cytochrome c
AKI39_RS19005	COG2080	2 iron, 2 sulfur cluster binding
AKI39_RS19010	COG2010	Cytochrome c
AKI39_RS19010	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AKI39_RS19015	COG0667	Aldo Keto reductase
AKI39_RS19055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AKI39_RS19070	COG0583	DNA-binding transcription factor activity
AKI39_RS19075	COG2814	Major facilitator Superfamily
AKI39_RS19080	COG2721	sulfolactate sulfo-lyase activity
AKI39_RS19090	COG2353	YceI-like domain
AKI39_RS19095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKI39_RS19100	COG0765	amino acid transport
AKI39_RS19105	COG1126	abc transporter atp-binding protein
AKI39_RS19110	COG0625	glutathione transferase activity
AKI39_RS19115	COG1309	transcriptional regulator
AKI39_RS19120	COG4977	sequence-specific DNA binding
AKI39_RS19120	COG1917	Cupin 2, conserved barrel domain protein
AKI39_RS19130	COG3829	transcription factor binding
AKI39_RS19140	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AKI39_RS19145	COG0066	3-isopropylmalate dehydratase activity
AKI39_RS19155	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AKI39_RS19175	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS19185	COG1278	Cold shock
AKI39_RS19190	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS19195	COG2814	Major facilitator Superfamily
AKI39_RS19205	COG3866	Pectate lyase
AKI39_RS19210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKI39_RS19215	COG4783	chaperone-mediated protein folding
AKI39_RS19215	COG1560	Kdo2-lipid A biosynthetic process
AKI39_RS19240	COG0438	transferase activity, transferring glycosyl groups
AKI39_RS19245	COG0457	Tetratricopeptide repeat
AKI39_RS19275	COG2982	Protein involved in outer membrane biogenesis
AKI39_RS19280	COG1368	sulfuric ester hydrolase activity
AKI39_RS19285	COG2205	protein histidine kinase activity
AKI39_RS19285	COG0784	Response regulator, receiver
AKI39_RS19300	COG0840	transmembrane signaling receptor activity
AKI39_RS19315	COG1450	Type ii and iii secretion system protein
AKI39_RS19320	COG4792	protein secretion
AKI39_RS19325	COG4791	protein targeting
AKI39_RS19330	COG4794	Type iii secretion
AKI39_RS19335	COG4790	Type iii secretion
AKI39_RS19370	COG4669	(LipO)protein
AKI39_RS19415	COG4789	Type iii secretion
AKI39_RS19445	COG2197	response regulator
AKI39_RS19460	COG0583	DNA-binding transcription factor activity
AKI39_RS19475	COG4172	Belongs to the ABC transporter superfamily
AKI39_RS19485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKI39_RS19490	COG0601	transmembrane transport
AKI39_RS19505	COG3799	methylaspartate ammonia-lyase activity
AKI39_RS19525	COG2011	ABC-type metal ion transport system permease component
AKI39_RS19530	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AKI39_RS19535	COG1501	Belongs to the glycosyl hydrolase 31 family
AKI39_RS19540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKI39_RS19540	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AKI39_RS19545	COG0483	inositol monophosphate 1-phosphatase activity
AKI39_RS19550	COG0318	PFAM AMP-dependent synthetase and ligase
AKI39_RS19555	COG1473	amidohydrolase
AKI39_RS19565	COG2855	membrane
AKI39_RS19575	COG2239	Acts as a magnesium transporter
AKI39_RS19590	COG1522	sequence-specific DNA binding
AKI39_RS19605	COG0028	Belongs to the TPP enzyme family
AKI39_RS19625	COG0653	protein targeting
AKI39_RS19630	COG0739	heme binding
AKI39_RS19640	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AKI39_RS19655	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AKI39_RS19660	COG1181	Belongs to the D-alanine--D-alanine ligase family
AKI39_RS19665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AKI39_RS19670	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AKI39_RS19680	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AKI39_RS19685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AKI39_RS19690	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AKI39_RS19700	COG3116	cell division
AKI39_RS19705	COG0275	rRNA processing
AKI39_RS19710	COG2001	Belongs to the MraZ family
AKI39_RS19730	COG0488	(ABC) transporter
AKI39_RS19735	COG0418	dihydroorotase activity
AKI39_RS19740	COG1473	amidohydrolase
AKI39_RS19795	COG0129	dihydroxy-acid dehydratase activity
AKI39_RS19800	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AKI39_RS19840	COG2084	Dehydrogenase
AKI39_RS19845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKI39_RS19860	COG0642	Histidine kinase
AKI39_RS19875	COG0442	prolyl-tRNA aminoacylation
AKI39_RS19880	COG0824	Thioesterase
AKI39_RS19885	COG0811	peptide transport
AKI39_RS19890	COG0848	biopolymer transport protein
AKI39_RS19900	COG0823	Involved in the tonB-independent uptake of proteins
AKI39_RS19920	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AKI39_RS19930	COG2885	chlorophyll binding
AKI39_RS20015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKI39_RS20025	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AKI39_RS20055	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AKI39_RS20080	COG1024	Enoyl-CoA hydratase
AKI39_RS20090	COG1940	carbohydrate kinase activity
AKI39_RS20100	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AKI39_RS20105	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AKI39_RS20110	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AKI39_RS20120	COG0363	glucosamine-6-phosphate deaminase activity
AKI39_RS20140	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AKI39_RS20145	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AKI39_RS20150	COG4948	Mandelate Racemase Muconate Lactonizing
AKI39_RS20155	COG0583	DNA-binding transcription factor activity
AKI39_RS20195	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS20200	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AKI39_RS20210	COG0477	Major facilitator Superfamily
AKI39_RS20220	COG0741	lytic transglycosylase activity
AKI39_RS20235	COG5265	(ABC) transporter
AKI39_RS20240	COG0297	glycogen (starch) synthase activity
AKI39_RS20245	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS20250	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AKI39_RS20255	COG0859	PFAM glycosyl transferase family 9
AKI39_RS20260	COG2192	nodulation
AKI39_RS20290	COG0463	Glycosyl transferase, family 2
AKI39_RS20315	COG0038	chloride channel
AKI39_RS20320	COG0583	DNA-binding transcription factor activity
AKI39_RS20355	COG0783	Belongs to the Dps family
AKI39_RS20360	COG4941	Belongs to the sigma-70 factor family
AKI39_RS20365	COG3795	YCII-related domain
AKI39_RS20380	COG0655	NAD(P)H dehydrogenase (quinone) activity
AKI39_RS20385	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AKI39_RS20390	COG2733	membrane
AKI39_RS20425	COG2200	EAL domain
AKI39_RS20430	COG2814	Major facilitator Superfamily
AKI39_RS20435	COG2155	Conserved Protein
AKI39_RS20440	COG0679	Auxin Efflux Carrier
AKI39_RS20445	COG0583	DNA-binding transcription factor activity
AKI39_RS20450	COG1132	(ABC) transporter
AKI39_RS20455	COG3328	transposase activity
AKI39_RS20495	COG2186	Transcriptional regulator
AKI39_RS20515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKI39_RS20525	COG5002	protein histidine kinase activity
AKI39_RS20560	COG0583	DNA-binding transcription factor activity
AKI39_RS20565	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS20570	COG0235	Class ii aldolase
AKI39_RS20575	COG0583	DNA-binding transcription factor activity
AKI39_RS20580	COG0583	DNA-binding transcription factor activity
AKI39_RS20595	COG4172	Belongs to the ABC transporter superfamily
AKI39_RS20600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKI39_RS20605	COG0601	transmembrane transport
AKI39_RS20610	COG0154	amidase activity
AKI39_RS20615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AKI39_RS20620	COG0583	DNA-binding transcription factor activity
AKI39_RS20625	COG0129	dihydroxy-acid dehydratase activity
AKI39_RS20640	COG1126	abc transporter atp-binding protein
AKI39_RS20645	COG0765	amino acid transport
AKI39_RS20650	COG0765	amino acid transport
AKI39_RS20660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKI39_RS20665	COG0251	oxidation-reduction process
AKI39_RS20670	COG0010	Belongs to the arginase family
AKI39_RS20675	COG0583	DNA-binding transcription factor activity
AKI39_RS20680	COG5265	(ABC) transporter
AKI39_RS20690	COG0747	negative chemotaxis
AKI39_RS20715	COG2814	Major facilitator Superfamily
AKI39_RS20720	COG3468	outer membrane autotransporter barrel domain protein
AKI39_RS20740	COG0701	Predicted permease
AKI39_RS20755	COG1104	cysteine desulfurase activity
AKI39_RS20765	COG5507	3-demethylubiquinone-9 3-methyltransferase
AKI39_RS20780	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AKI39_RS20810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKI39_RS20815	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS20825	COG1418	mRNA catabolic process
AKI39_RS20840	COG0668	transmembrane transport
AKI39_RS20860	COG0583	DNA-binding transcription factor activity
AKI39_RS20875	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS20880	COG0583	DNA-binding transcription factor activity
AKI39_RS20895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKI39_RS20925	COG1881	PFAM PEBP family protein
AKI39_RS20930	COG3328	transposase activity
AKI39_RS20935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKI39_RS20955	COG0840	transmembrane signaling receptor activity
AKI39_RS20970	COG0066	3-isopropylmalate dehydratase activity
AKI39_RS20975	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AKI39_RS20985	COG0456	acetyltransferase
AKI39_RS21010	COG0477	Major facilitator Superfamily
AKI39_RS21015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AKI39_RS21030	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS21035	COG2271	Major facilitator Superfamily
AKI39_RS21045	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AKI39_RS21050	COG0583	DNA-binding transcription factor activity
AKI39_RS21075	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AKI39_RS21080	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS21085	COG3128	pkhd-type hydroxylase
AKI39_RS21090	COG4774	siderophore transport
AKI39_RS21105	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS21110	COG1942	4-Oxalocrotonate Tautomerase
AKI39_RS21135	COG1595	DNA-templated transcription, initiation
AKI39_RS21145	COG2223	nitrite transmembrane transporter activity
AKI39_RS21150	COG0583	DNA-binding transcription factor activity
AKI39_RS21170	COG1280	lysine exporter protein (LysE YggA)
AKI39_RS21180	COG0625	glutathione transferase activity
AKI39_RS21190	COG0583	DNA-binding transcription factor activity
AKI39_RS21210	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AKI39_RS21225	COG1573	uracil-dna glycosylase
AKI39_RS21230	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AKI39_RS21240	COG1522	sequence-specific DNA binding
AKI39_RS21250	COG2814	Major facilitator Superfamily
AKI39_RS21300	COG0583	DNA-binding transcription factor activity
AKI39_RS21305	COG3485	protocatechuate 3,4-dioxygenase
AKI39_RS21310	COG3485	protocatechuate 3,4-dioxygenase
AKI39_RS21320	COG2267	carboxylic ester hydrolase activity
AKI39_RS21330	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS21335	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS21390	COG0514	ATP-dependent DNA helicase (RecQ)
AKI39_RS21405	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AKI39_RS21440	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AKI39_RS21445	COG0784	Response regulator, receiver
AKI39_RS21445	COG4191	Histidine kinase
AKI39_RS21485	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS21510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AKI39_RS21540	COG1902	pentaerythritol trinitrate reductase activity
AKI39_RS21545	COG1733	regulation of RNA biosynthetic process
AKI39_RS21560	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS21565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AKI39_RS21595	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS21620	COG4948	Mandelate Racemase Muconate Lactonizing
AKI39_RS21625	COG0583	DNA-binding transcription factor activity
AKI39_RS21695	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS21710	COG1275	C4-dicarboxylate transporter malic acid transport protein
AKI39_RS21730	COG1335	isochorismatase
AKI39_RS21750	COG4221	oxidoreductase activity
AKI39_RS21765	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AKI39_RS21800	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AKI39_RS21805	COG0459	protein refolding
AKI39_RS21825	COG4166	transmembrane transport
AKI39_RS21835	COG3328	transposase activity
AKI39_RS21895	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AKI39_RS21920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKI39_RS21930	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AKI39_RS21935	COG0237	dephospho-CoA kinase activity
AKI39_RS21940	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AKI39_RS21950	COG2197	response regulator
AKI39_RS21955	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AKI39_RS21960	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AKI39_RS21970	COG0477	Major facilitator Superfamily
AKI39_RS21995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AKI39_RS22030	COG0625	glutathione transferase activity
AKI39_RS22040	COG4221	oxidoreductase activity
AKI39_RS22040	COG0604	alcohol dehydrogenase
AKI39_RS22040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AKI39_RS22040	COG3321	synthase
AKI39_RS22055	COG1126	abc transporter atp-binding protein
AKI39_RS22060	COG0765	amino acid transport
AKI39_RS22065	COG4597	amino acid ABC transporter
AKI39_RS22070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKI39_RS22075	COG2884	Cell division ATP-binding protein ftsE
AKI39_RS22080	COG2177	Part of the ABC transporter FtsEX involved in
AKI39_RS22085	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AKI39_RS22125	COG1194	a g-specific adenine glycosylase
AKI39_RS22130	COG0772	Belongs to the SEDS family
AKI39_RS22135	COG0768	penicillin binding
AKI39_RS22145	COG1792	Involved in formation and maintenance of cell shape
AKI39_RS22150	COG1077	Cell shape determining protein MreB Mrl
AKI39_RS22155	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKI39_RS22160	COG0154	amidase activity
AKI39_RS22165	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKI39_RS22170	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AKI39_RS22175	COG0708	Exodeoxyribonuclease III
AKI39_RS22185	COG0589	response to stress
AKI39_RS22195	COG2223	nitrite transmembrane transporter activity
AKI39_RS22200	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AKI39_RS22200	COG2813	Specifically methylates the guanine in position
AKI39_RS22205	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AKI39_RS22210	COG2197	response regulator
AKI39_RS22220	COG2918	glutathione biosynthetic process
AKI39_RS22230	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AKI39_RS22240	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKI39_RS22255	COG0473	3-isopropylmalate dehydrogenase activity
AKI39_RS22265	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AKI39_RS22275	COG0583	DNA-binding transcription factor activity
AKI39_RS22295	COG2885	chlorophyll binding
AKI39_RS22325	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AKI39_RS22325	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AKI39_RS22330	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AKI39_RS22350	COG0583	DNA-binding transcription factor activity
AKI39_RS22380	COG3052	prosthetic group binding
AKI39_RS22395	COG4206	TonB-dependent receptor
AKI39_RS22400	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKI39_RS22405	COG2022	thiamine diphosphate biosynthetic process
AKI39_RS22410	COG0351	phosphomethylpyrimidine kinase
AKI39_RS22415	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AKI39_RS22420	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AKI39_RS22430	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AKI39_RS22445	COG2226	methyltransferase
AKI39_RS22450	COG0745	RESPONSE REGULATOR receiver
AKI39_RS22455	COG5002	protein histidine kinase activity
AKI39_RS22460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKI39_RS22475	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AKI39_RS22480	COG1984	allophanate hydrolase subunit 2
AKI39_RS22490	COG1802	Transcriptional regulator
AKI39_RS22500	COG1238	metal cluster binding
AKI39_RS22505	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AKI39_RS22525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AKI39_RS22540	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AKI39_RS22545	COG0583	DNA-binding transcription factor activity
AKI39_RS22555	COG0601	transmembrane transport
AKI39_RS22560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKI39_RS22565	COG0444	Belongs to the ABC transporter superfamily
AKI39_RS22570	COG4608	Belongs to the ABC transporter superfamily
AKI39_RS22595	COG3618	amidohydrolase
AKI39_RS22620	COG1116	anion transmembrane transporter activity
AKI39_RS22630	COG0210	DNA helicase
AKI39_RS22635	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AKI39_RS22640	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AKI39_RS22655	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKI39_RS22660	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AKI39_RS22665	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AKI39_RS22670	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AKI39_RS22675	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AKI39_RS22680	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AKI39_RS22695	COG0356	it plays a direct role in the translocation of protons across the membrane
AKI39_RS22715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKI39_RS22720	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AKI39_RS22725	COG3634	alkyl hydroperoxide reductase activity
AKI39_RS22735	COG0037	tRNA processing
AKI39_RS22745	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AKI39_RS22750	COG2890	protein-(glutamine-N5) methyltransferase activity
AKI39_RS22755	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AKI39_RS22770	COG3023	N-Acetylmuramoyl-L-alanine amidase
AKI39_RS22785	COG2818	Glycosylase
AKI39_RS22790	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
AKI39_RS22795	COG1230	cation diffusion facilitator family transporter
AKI39_RS22810	COG0583	DNA-binding transcription factor activity
AKI39_RS22840	COG3069	C4-dicarboxylate transmembrane transporter activity
AKI39_RS22845	COG1802	Transcriptional regulator
AKI39_RS22890	COG2943	transferase activity, transferring hexosyl groups
AKI39_RS22895	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKI39_RS22900	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AKI39_RS22905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKI39_RS22910	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AKI39_RS22915	COG2967	ApaG domain
AKI39_RS22920	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AKI39_RS22925	COG0546	phosphoglycolate phosphatase activity
AKI39_RS22935	COG0512	Glutamine amidotransferase of anthranilate synthase
AKI39_RS22940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AKI39_RS22950	COG1607	acyl-coa hydrolase
AKI39_RS22960	COG3387	PFAM Glycoside hydrolase 15-related
AKI39_RS22965	COG2814	Major facilitator Superfamily
AKI39_RS22975	COG0235	Class ii aldolase
AKI39_RS22985	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AKI39_RS22995	COG1309	transcriptional regulator
AKI39_RS23000	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AKI39_RS23005	COG0793	Belongs to the peptidase S41A family
AKI39_RS23010	COG4942	peptidase
AKI39_RS23015	COG0588	phosphoglycerate mutase activity
AKI39_RS23030	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AKI39_RS23035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AKI39_RS23060	COG2226	methyltransferase
AKI39_RS23065	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AKI39_RS23070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AKI39_RS23075	COG0569	domain protein
AKI39_RS23080	COG2204	response regulator
AKI39_RS23085	COG5000	phosphorelay sensor kinase activity
AKI39_RS23095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AKI39_RS23095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AKI39_RS23115	COG3119	arylsulfatase activity
AKI39_RS23120	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AKI39_RS23130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKI39_RS23160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AKI39_RS23165	COG0242	peptide deformylase activity
AKI39_RS23170	COG0758	DNA mediated transformation
AKI39_RS23185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKI39_RS23225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKI39_RS23245	COG1172	Belongs to the binding-protein-dependent transport system permease family
AKI39_RS23280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKI39_RS23295	COG1850	ribulose-bisphosphate carboxylase activity
AKI39_RS23305	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AKI39_RS23310	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKI39_RS23315	COG0583	DNA-binding transcription factor activity
AKI39_RS23340	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AKI39_RS23345	COG0513	Belongs to the DEAD box helicase family
AKI39_RS23360	COG0617	tRNA 3'-terminal CCA addition
AKI39_RS23370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AKI39_RS23390	COG1950	PFAM Membrane protein of
AKI39_RS23400	COG0438	transferase activity, transferring glycosyl groups
AKI39_RS23410	COG0596	Alpha beta hydrolase
AKI39_RS23415	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AKI39_RS23430	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AKI39_RS23440	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AKI39_RS23465	COG0735	belongs to the Fur family
AKI39_RS23470	COG0523	cobalamin synthesis protein
AKI39_RS23480	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AKI39_RS23485	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AKI39_RS23500	COG2096	Adenosyltransferase
AKI39_RS23510	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AKI39_RS23515	COG0321	lipoyl(octanoyl) transferase activity
AKI39_RS23520	COG2921	Belongs to the UPF0250 family
AKI39_RS23530	COG1686	Belongs to the peptidase S11 family
AKI39_RS23540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AKI39_RS23560	COG1127	ABC transporter
AKI39_RS23565	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AKI39_RS23575	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AKI39_RS23595	COG4106	trans-aconitate 2-methyltransferase activity
AKI39_RS23600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AKI39_RS23625	COG0859	PFAM glycosyl transferase family 9
AKI39_RS23635	COG0438	transferase activity, transferring glycosyl groups
AKI39_RS23640	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AKI39_RS23660	COG0438	transferase activity, transferring glycosyl groups
AKI39_RS23690	COG1216	Glycosyl transferase, family 2
AKI39_RS23690	COG0438	transferase activity, transferring glycosyl groups
AKI39_RS23700	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AKI39_RS23720	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AKI39_RS23735	COG0183	Belongs to the thiolase family
AKI39_RS23740	COG1024	Enoyl-CoA hydratase
AKI39_RS23740	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKI39_RS23755	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AKI39_RS23775	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AKI39_RS23785	COG2188	Transcriptional regulator
AKI39_RS23790	COG2301	Belongs to the HpcH HpaI aldolase family
AKI39_RS23795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AKI39_RS23810	COG1137	ATPase activity
AKI39_RS23820	COG0410	ABC transporter
AKI39_RS23855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AKI39_RS23860	COG1956	GAF domain-containing protein
AKI39_RS23865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKI39_RS23880	COG1960	acyl-CoA dehydrogenase activity
AKI39_RS23890	COG0045	succinate-CoA ligase (ADP-forming) activity
AKI39_RS23895	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AKI39_RS23900	COG3328	transposase activity
AKI39_RS23905	COG0583	DNA-binding transcription factor activity
AKI39_RS23910	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AKI39_RS23920	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS23925	COG1840	ABC-type Fe3 transport system, periplasmic component
AKI39_RS23930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKI39_RS23945	COG1177	transmembrane transport
AKI39_RS23950	COG1176	ABC-type spermidine putrescine transport system, permease component I
AKI39_RS23955	COG3842	ATPase activity
AKI39_RS23960	COG1414	Transcriptional regulator
AKI39_RS23965	COG3328	transposase activity
AKI39_RS23970	COG0583	DNA-binding transcription factor activity
AKI39_RS23985	COG3181	Tripartite tricarboxylate transporter family receptor
AKI39_RS23995	COG0583	DNA-binding transcription factor activity
AKI39_RS24015	COG1012	belongs to the aldehyde dehydrogenase family
AKI39_RS24020	COG2188	Transcriptional regulator
AKI39_RS24025	COG1028	Short-chain dehydrogenase reductase Sdr
AKI39_RS24065	COG2011	ABC-type metal ion transport system permease component
AKI39_RS24110	COG1737	Transcriptional regulator
AKI39_RS24115	COG1011	Hydrolase
AKI39_RS24215	COG0513	Belongs to the DEAD box helicase family
AKI39_RS24230	COG2814	Major facilitator Superfamily
AKI39_RS24250	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AKI39_RS24255	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AKI39_RS24260	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AKI39_RS24270	COG1965	Belongs to the frataxin family
AKI39_RS24280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AKI39_RS24285	COG1333	cytochrome c biogenesis protein
AKI39_RS24295	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AKI39_RS24310	COG4232	protein-disulfide reductase activity
AKI39_RS24315	COG1324	tolerance protein
AKI39_RS24320	COG0203	ribosomal protein L17
AKI39_RS24325	COG0202	RNA polymerase activity
AKI39_RS24330	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AKI39_RS24335	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AKI39_RS24340	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AKI39_RS24345	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AKI39_RS24355	COG0201	protein transport
AKI39_RS24360	COG0200	Binds to the 23S rRNA
AKI39_RS24365	COG1841	ribosomal large subunit assembly
AKI39_RS24370	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AKI39_RS24375	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AKI39_RS24380	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AKI39_RS24385	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AKI39_RS24390	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AKI39_RS24395	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AKI39_RS24400	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AKI39_RS24405	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AKI39_RS24425	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AKI39_RS24430	COG0255	Belongs to the universal ribosomal protein uL29 family
AKI39_RS24435	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AKI39_RS24440	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AKI39_RS24445	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AKI39_RS24450	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AKI39_RS24455	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AKI39_RS24460	COG0089	rRNA binding
AKI39_RS24470	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AKI39_RS24475	COG0051	transcription antitermination factor activity, RNA binding
AKI39_RS24480	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AKI39_RS24485	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AKI39_RS24490	COG0049	tRNA binding
AKI39_RS24495	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AKI39_RS24545	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AKI39_RS24550	COG0085	RNA polymerase activity
AKI39_RS24555	COG0222	ribosome binding
AKI39_RS24560	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AKI39_RS24565	COG0081	regulation of translation
AKI39_RS24570	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AKI39_RS24580	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AKI39_RS24590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AKI39_RS24615	COG1012	belongs to the aldehyde dehydrogenase family
AKI39_RS24625	COG1349	DNA-binding transcription factor activity
AKI39_RS24630	COG0252	asparaginase activity
AKI39_RS24635	COG1475	DNA binding
AKI39_RS24645	COG1192	Involved in chromosome partitioning
AKI39_RS24650	COG0357	Ribosomal RNA small subunit methyltransferase G
AKI39_RS24655	COG0445	tRNA wobble uridine modification
AKI39_RS24660	COG1278	Cold shock
AKI39_RS24665	COG0436	Aminotransferase
AKI39_RS24705	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AKI39_RS24710	COG0747	negative chemotaxis
AKI39_RS24720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKI39_RS24725	COG0444	Belongs to the ABC transporter superfamily
AKI39_RS24730	COG4608	Belongs to the ABC transporter superfamily
AKI39_RS24740	COG1473	amidohydrolase
AKI39_RS24745	COG1960	acyl-CoA dehydrogenase activity
AKI39_RS24760	COG0583	DNA-binding transcription factor activity
AKI39_RS24765	COG0706	membrane insertase activity
AKI39_RS24770	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AKI39_RS24775	COG0594	ribonuclease P activity
AKI39_RS24780	COG0230	Belongs to the bacterial ribosomal protein bL34 family