locus-tag	class	description
G6Z49_RS00010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G6Z49_RS00020	COG0477	Major facilitator Superfamily
G6Z49_RS00035	COG1088	dTDP-glucose 4,6-dehydratase activity
G6Z49_RS00040	COG1091	dTDP-4-dehydrorhamnose reductase activity
G6Z49_RS00045	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
G6Z49_RS00055	COG0859	PFAM glycosyl transferase family 9
G6Z49_RS00070	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
G6Z49_RS00080	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G6Z49_RS00105	COG1686	Belongs to the peptidase S11 family
G6Z49_RS00115	COG2921	Belongs to the UPF0250 family
G6Z49_RS00120	COG0321	lipoyl(octanoyl) transferase activity
G6Z49_RS00125	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G6Z49_RS00130	COG2096	Adenosyltransferase
G6Z49_RS00140	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
G6Z49_RS00145	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
G6Z49_RS00155	COG0523	cobalamin synthesis protein
G6Z49_RS00160	COG0735	belongs to the Fur family
G6Z49_RS00165	COG1121	(ABC) transporter
G6Z49_RS00170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G6Z49_RS00185	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
G6Z49_RS00195	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
G6Z49_RS00205	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
G6Z49_RS00220	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G6Z49_RS00235	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
G6Z49_RS00240	COG1950	PFAM Membrane protein of
G6Z49_RS00245	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
G6Z49_RS00255	COG3220	belongs to the UPF0276 family
G6Z49_RS00265	COG2259	Doxx family
G6Z49_RS00280	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G6Z49_RS00300	COG0513	Belongs to the DEAD box helicase family
G6Z49_RS00305	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G6Z49_RS00310	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G6Z49_RS00330	COG0735	belongs to the Fur family
G6Z49_RS00360	COG0640	Transcriptional regulator
G6Z49_RS00420	COG0583	DNA-binding transcription factor activity
G6Z49_RS00425	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
G6Z49_RS00430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G6Z49_RS00435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6Z49_RS00455	COG0758	DNA mediated transformation
G6Z49_RS00470	COG1966	Carbon starvation protein
G6Z49_RS00475	COG2879	small protein
G6Z49_RS00480	COG1522	sequence-specific DNA binding
G6Z49_RS00490	COG0242	peptide deformylase activity
G6Z49_RS00495	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G6Z49_RS00505	COG0546	phosphoglycolate phosphatase activity
G6Z49_RS00520	COG2188	Transcriptional regulator
G6Z49_RS00535	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS00545	COG1960	acyl-CoA dehydrogenase activity
G6Z49_RS00550	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G6Z49_RS00565	COG2204	response regulator
G6Z49_RS00565	COG2204	response regulator
G6Z49_RS00570	COG0569	domain protein
G6Z49_RS00575	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G6Z49_RS00580	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
G6Z49_RS00585	COG2226	methyltransferase
G6Z49_RS00590	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G6Z49_RS00600	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS00605	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G6Z49_RS00610	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
G6Z49_RS00615	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G6Z49_RS00625	COG0588	phosphoglycerate mutase activity
G6Z49_RS00630	COG4942	peptidase
G6Z49_RS00635	COG0793	Belongs to the peptidase S41A family
G6Z49_RS00640	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G6Z49_RS00655	COG0861	Integral membrane protein TerC family
G6Z49_RS00660	COG0583	DNA-binding transcription factor activity
G6Z49_RS00670	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
G6Z49_RS00675	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G6Z49_RS00695	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
G6Z49_RS00700	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G6Z49_RS00705	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G6Z49_RS00710	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G6Z49_RS00715	COG0142	geranyltranstransferase activity
G6Z49_RS00725	COG0154	amidase activity
G6Z49_RS00735	COG1137	ATPase activity
G6Z49_RS00760	COG1024	Enoyl-CoA hydratase
G6Z49_RS00770	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G6Z49_RS00785	COG1473	amidohydrolase
G6Z49_RS00800	COG2267	carboxylic ester hydrolase activity
G6Z49_RS00815	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS00820	COG1012	belongs to the aldehyde dehydrogenase family
G6Z49_RS00840	COG0583	DNA-binding transcription factor activity
G6Z49_RS00845	COG0626	cystathionine gamma-synthase activity
G6Z49_RS00850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6Z49_RS00855	COG0765	amino acid transport
G6Z49_RS00860	COG0765	amino acid transport
G6Z49_RS00865	COG1126	abc transporter atp-binding protein
G6Z49_RS00870	COG3608	succinylglutamate desuccinylase aspartoacylase
G6Z49_RS00875	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS00885	COG3608	succinylglutamate desuccinylase aspartoacylase
G6Z49_RS00900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6Z49_RS00905	COG0765	amino acid transport
G6Z49_RS00910	COG0765	amino acid transport
G6Z49_RS00915	COG1126	abc transporter atp-binding protein
G6Z49_RS00920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G6Z49_RS00935	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G6Z49_RS00955	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
G6Z49_RS00960	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G6Z49_RS00965	COG2890	protein-(glutamine-N5) methyltransferase activity
G6Z49_RS00970	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G6Z49_RS00990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G6Z49_RS00995	COG0288	reversible hydration of carbon dioxide
G6Z49_RS01010	COG0596	Alpha beta hydrolase
G6Z49_RS01020	COG4829	muconolactone delta-isomerase
G6Z49_RS01025	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G6Z49_RS01035	COG1414	Transcriptional regulator
G6Z49_RS01040	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS01045	COG2031	fatty acid transporter
G6Z49_RS01050	COG1250	3-hydroxyacyl-CoA dehydrogenase
G6Z49_RS01055	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
G6Z49_RS01060	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
G6Z49_RS01065	COG0129	dihydroxy-acid dehydratase activity
G6Z49_RS01070	COG3539	Fimbrial protein
G6Z49_RS01075	COG3539	Fimbrial protein
G6Z49_RS01080	COG3539	Fimbrial protein
G6Z49_RS01090	COG3539	Fimbrial protein
G6Z49_RS01095	COG3539	Fimbrial protein
G6Z49_RS01100	COG3539	Fimbrial protein
G6Z49_RS01105	COG3539	Fimbrial protein
G6Z49_RS01110	COG3539	Fimbrial protein
G6Z49_RS01115	COG3539	Fimbrial protein
G6Z49_RS01120	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
G6Z49_RS01140	COG0583	DNA-binding transcription factor activity
G6Z49_RS01145	COG0628	permease
G6Z49_RS01155	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G6Z49_RS01175	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G6Z49_RS01180	COG1653	transport
G6Z49_RS01185	COG0395	ABC-type sugar transport system, permease component
G6Z49_RS01190	COG1175	transmembrane transport
G6Z49_RS01195	COG3842	ATPase activity
G6Z49_RS01200	COG0546	phosphoglycolate phosphatase activity
G6Z49_RS01230	COG1064	alcohol dehydrogenase
G6Z49_RS01245	COG0583	DNA-binding transcription factor activity
G6Z49_RS01270	COG2819	hydrolase of the alpha beta superfamily
G6Z49_RS01280	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6Z49_RS01285	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G6Z49_RS01290	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS01310	COG0235	Class ii aldolase
G6Z49_RS01345	COG1177	transmembrane transport
G6Z49_RS01350	COG0318	PFAM AMP-dependent synthetase and ligase
G6Z49_RS01355	COG1024	Enoyl-CoA hydratase
G6Z49_RS01360	COG0604	alcohol dehydrogenase
G6Z49_RS01370	COG2130	NADP-dependent
G6Z49_RS01385	COG0583	DNA-binding transcription factor activity
G6Z49_RS01390	COG0625	glutathione transferase activity
G6Z49_RS01395	COG1942	4-Oxalocrotonate Tautomerase
G6Z49_RS01450	COG2801	Transposase and inactivated derivatives
G6Z49_RS01480	COG2233	PERMEase
G6Z49_RS01485	COG0326	Molecular chaperone. Has ATPase activity
G6Z49_RS01490	COG0625	glutathione transferase activity
G6Z49_RS01510	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G6Z49_RS01515	COG1652	LysM domain
G6Z49_RS01530	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G6Z49_RS01545	COG0582	viral genome integration into host DNA
G6Z49_RS01595	COG0629	single-stranded DNA binding
G6Z49_RS01600	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G6Z49_RS01800	COG2003	Belongs to the UPF0758 family
G6Z49_RS01925	COG3344	reverse transcriptase
G6Z49_RS01970	COG0135	phosphoribosylanthranilate isomerase activity
G6Z49_RS01990	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G6Z49_RS01995	COG0625	glutathione transferase activity
G6Z49_RS02000	COG0598	Magnesium transport protein CorA
G6Z49_RS02045	COG1695	Transcriptional regulator
G6Z49_RS02070	COG3173	Aminoglycoside phosphotransferase
G6Z49_RS02160	COG4245	von Willebrand factor, type A
G6Z49_RS02165	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
G6Z49_RS02170	COG4804	nuclease activity
G6Z49_RS02195	COG0583	DNA-binding transcription factor activity
G6Z49_RS02205	COG0464	growth
G6Z49_RS02225	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS02230	COG4689	acetoacetate decarboxylase
G6Z49_RS02240	COG0154	amidase activity
G6Z49_RS02245	COG0477	Major facilitator Superfamily
G6Z49_RS02275	COG3384	dioxygenase
G6Z49_RS02285	COG1802	Transcriptional regulator
G6Z49_RS02300	COG0179	Fumarylacetoacetate (FAA) hydrolase
G6Z49_RS02310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6Z49_RS02320	COG1522	sequence-specific DNA binding
G6Z49_RS02325	COG0583	DNA-binding transcription factor activity
G6Z49_RS02330	COG0626	cystathionine gamma-synthase activity
G6Z49_RS02335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G6Z49_RS02340	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS02350	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS02365	COG0019	diaminopimelate decarboxylase activity
G6Z49_RS02375	COG3246	L-lysine catabolic process to acetate
G6Z49_RS02385	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS02395	COG0583	DNA-binding transcription factor activity
G6Z49_RS02440	COG1294	oxidase, subunit
G6Z49_RS02445	COG1271	oxidase subunit
G6Z49_RS02450	COG0583	DNA-binding transcription factor activity
G6Z49_RS02455	COG1024	Enoyl-CoA hydratase
G6Z49_RS02455	COG1250	3-hydroxyacyl-CoA dehydrogenase
G6Z49_RS02460	COG0183	Belongs to the thiolase family
G6Z49_RS02465	COG1960	acyl-CoA dehydrogenase activity
G6Z49_RS02470	COG1960	acyl-CoA dehydrogenase activity
G6Z49_RS02475	COG1024	Enoyl-CoA hydratase
G6Z49_RS02480	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6Z49_RS02485	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS02500	COG0583	DNA-binding transcription factor activity
G6Z49_RS02525	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G6Z49_RS02550	COG0693	protein deglycase activity
G6Z49_RS02565	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
G6Z49_RS02570	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
G6Z49_RS02575	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
G6Z49_RS02580	COG2205	protein histidine kinase activity
G6Z49_RS02585	COG0745	RESPONSE REGULATOR receiver
G6Z49_RS02590	COG1053	succinate dehydrogenase
G6Z49_RS02590	COG3976	FMN-binding domain protein
G6Z49_RS02595	COG0477	Major facilitator Superfamily
G6Z49_RS02600	COG0129	dihydroxy-acid dehydratase activity
G6Z49_RS02605	COG2186	Transcriptional regulator
G6Z49_RS02620	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G6Z49_RS02625	COG3842	ATPase activity
G6Z49_RS02640	COG2423	ornithine cyclodeaminase activity
G6Z49_RS02645	COG2204	response regulator
G6Z49_RS02650	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G6Z49_RS02665	COG0439	Biotin carboxylase
G6Z49_RS02670	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
G6Z49_RS02680	COG0183	Belongs to the thiolase family
G6Z49_RS02685	COG1250	3-hydroxyacyl-CoA dehydrogenase
G6Z49_RS02685	COG1024	Enoyl-CoA hydratase
G6Z49_RS02715	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS02720	COG1522	sequence-specific DNA binding
G6Z49_RS02725	COG0010	Belongs to the arginase family
G6Z49_RS02730	COG3539	Fimbrial protein
G6Z49_RS02760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G6Z49_RS02760	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G6Z49_RS02770	COG0489	protein tyrosine kinase activity
G6Z49_RS02785	COG0717	Belongs to the dCTP deaminase family
G6Z49_RS02790	COG0456	acetyltransferase
G6Z49_RS02800	COG1982	Orn Lys Arg decarboxylase major
G6Z49_RS02805	COG2081	HI0933 family
G6Z49_RS02810	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G6Z49_RS02815	COG0509	glycine decarboxylation via glycine cleavage system
G6Z49_RS02820	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G6Z49_RS02820	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G6Z49_RS02830	COG5339	Protein conserved in bacteria
G6Z49_RS02850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G6Z49_RS02870	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
G6Z49_RS02875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G6Z49_RS02880	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
G6Z49_RS02895	COG0438	transferase activity, transferring glycosyl groups
G6Z49_RS02910	COG0438	transferase activity, transferring glycosyl groups
G6Z49_RS02915	COG0438	transferase activity, transferring glycosyl groups
G6Z49_RS02920	COG0166	Belongs to the GPI family
G6Z49_RS02935	COG0277	FAD linked oxidase domain protein
G6Z49_RS02940	COG0745	RESPONSE REGULATOR receiver
G6Z49_RS02945	COG0642	Histidine kinase
G6Z49_RS02950	COG2186	Transcriptional regulator
G6Z49_RS02955	COG1368	sulfuric ester hydrolase activity
G6Z49_RS02960	COG1629	transport
G6Z49_RS02960	COG4771	TonB-dependent receptor
G6Z49_RS02970	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
G6Z49_RS02985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G6Z49_RS02995	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G6Z49_RS03005	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
G6Z49_RS03010	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G6Z49_RS03020	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G6Z49_RS03025	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
G6Z49_RS03030	COG0193	aminoacyl-tRNA hydrolase activity
G6Z49_RS03040	COG0012	GTP binding
G6Z49_RS03060	COG0784	Response regulator, receiver
G6Z49_RS03060	COG2205	protein histidine kinase activity
G6Z49_RS03065	COG0784	Response regulator, receiver
G6Z49_RS03065	COG2205	protein histidine kinase activity
G6Z49_RS03070	COG2197	response regulator
G6Z49_RS03075	COG1113	amino acid transport
G6Z49_RS03090	COG3121	Chaperone
G6Z49_RS03130	COG3135	benzoate transporter
G6Z49_RS03135	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G6Z49_RS03140	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G6Z49_RS03145	COG0742	ribosomal rna small subunit methyltransferase
G6Z49_RS03155	COG0625	glutathione transferase activity
G6Z49_RS03160	COG0477	Major facilitator Superfamily
G6Z49_RS03180	COG3639	organic phosphonate transmembrane transporter activity
G6Z49_RS03185	COG3639	organic phosphonate transmembrane transporter activity
G6Z49_RS03190	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
G6Z49_RS03205	COG1414	Transcriptional regulator
G6Z49_RS03220	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
G6Z49_RS03225	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G6Z49_RS03230	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
G6Z49_RS03235	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
G6Z49_RS03240	COG1546	Belongs to the CinA family
G6Z49_RS03245	COG0284	orotidine-5'-phosphate decarboxylase activity
G6Z49_RS03250	COG1252	NADH dehydrogenase
G6Z49_RS03255	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
G6Z49_RS03260	COG1295	ribonuclease BN
G6Z49_RS03265	COG0459	protein refolding
G6Z49_RS03270	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G6Z49_RS03275	COG0583	DNA-binding transcription factor activity
G6Z49_RS03290	COG2721	sulfolactate sulfo-lyase activity
G6Z49_RS03305	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G6Z49_RS03310	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS03340	COG0698	ribose 5-phosphate isomerase
G6Z49_RS03350	COG3395	kinase activity
G6Z49_RS03355	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G6Z49_RS03375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6Z49_RS03400	COG0833	amino acid
G6Z49_RS03405	COG0833	amino acid
G6Z49_RS03410	COG0513	Belongs to the DEAD box helicase family
G6Z49_RS03425	COG2199	diguanylate cyclase activity
G6Z49_RS03425	COG2203	Gaf domain
G6Z49_RS03445	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G6Z49_RS03450	COG0318	PFAM AMP-dependent synthetase and ligase
G6Z49_RS03460	COG4566	intracellular signal transduction
G6Z49_RS03480	COG0642	Histidine kinase
G6Z49_RS03485	COG0745	RESPONSE REGULATOR receiver
G6Z49_RS03505	COG2814	Major facilitator Superfamily
G6Z49_RS03505	COG0477	Major facilitator Superfamily
G6Z49_RS03515	COG2375	cellular response to nickel ion
G6Z49_RS03520	COG1695	Transcriptional regulator
G6Z49_RS03530	COG0028	Belongs to the TPP enzyme family
G6Z49_RS03535	COG0668	transmembrane transport
G6Z49_RS03540	COG0668	transmembrane transport
G6Z49_RS03545	COG1396	sequence-specific DNA binding
G6Z49_RS03555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6Z49_RS03565	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
G6Z49_RS03570	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G6Z49_RS03575	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS03580	COG2271	Major facilitator Superfamily
G6Z49_RS03610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6Z49_RS03615	COG1024	Enoyl-CoA hydratase
G6Z49_RS03630	COG0431	NADPH-dependent FMN reductase
G6Z49_RS03660	COG1802	Transcriptional regulator
G6Z49_RS03675	COG0477	Major facilitator Superfamily
G6Z49_RS03680	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS03695	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS03705	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS03710	COG0583	DNA-binding transcription factor activity
G6Z49_RS03720	COG1999	signal sequence binding
G6Z49_RS03750	COG3048	D-serine ammonia-lyase activity
G6Z49_RS03760	COG2207	Transcriptional regulator
G6Z49_RS03770	COG2814	Major facilitator Superfamily
G6Z49_RS03780	COG0583	DNA-binding transcription factor activity
G6Z49_RS03790	COG0154	amidase activity
G6Z49_RS03800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G6Z49_RS03805	COG0028	Belongs to the TPP enzyme family
G6Z49_RS03825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G6Z49_RS03830	COG0640	Transcriptional regulator
G6Z49_RS03865	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS03870	COG0028	Belongs to the TPP enzyme family
G6Z49_RS03880	COG0025	NhaP-type Na H and K H
G6Z49_RS03905	COG0076	glutamate decarboxylase activity
G6Z49_RS03920	COG1228	amidohydrolase
G6Z49_RS03945	COG0410	ABC transporter
G6Z49_RS03970	COG1414	Transcriptional regulator
G6Z49_RS03980	COG0786	glutamate:sodium symporter activity
G6Z49_RS04000	COG1609	Transcriptional regulator
G6Z49_RS04005	COG4172	Belongs to the ABC transporter superfamily
G6Z49_RS04015	COG0601	transmembrane transport
G6Z49_RS04035	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
G6Z49_RS04065	COG2814	Major facilitator Superfamily
G6Z49_RS04070	COG0625	glutathione transferase activity
G6Z49_RS04075	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS04080	COG2272	Belongs to the type-B carboxylesterase lipase family
G6Z49_RS04095	COG0251	oxidation-reduction process
G6Z49_RS04105	COG0747	negative chemotaxis
G6Z49_RS04110	COG0601	transmembrane transport
G6Z49_RS04115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6Z49_RS04120	COG0444	Belongs to the ABC transporter superfamily
G6Z49_RS04125	COG4608	Belongs to the ABC transporter superfamily
G6Z49_RS04130	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
G6Z49_RS04150	COG1012	belongs to the aldehyde dehydrogenase family
G6Z49_RS04155	COG3284	Transcriptional regulator
G6Z49_RS04175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G6Z49_RS04190	COG2885	chlorophyll binding
G6Z49_RS04210	COG5265	(ABC) transporter
G6Z49_RS04255	COG0456	acetyltransferase
G6Z49_RS04265	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
G6Z49_RS04275	COG1408	metallophosphoesterase
G6Z49_RS04285	COG2610	gluconate transmembrane transporter activity
G6Z49_RS04290	COG2070	2-Nitropropane dioxygenase
G6Z49_RS04300	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
G6Z49_RS04315	COG0747	negative chemotaxis
G6Z49_RS04320	COG0405	Gamma-glutamyltransferase
G6Z49_RS04330	COG0583	DNA-binding transcription factor activity
G6Z49_RS04335	COG1380	Effector of murein hydrolase LrgA
G6Z49_RS04340	COG1346	cytolysis
G6Z49_RS04355	COG2132	Multicopper oxidase
G6Z49_RS04360	COG0783	Belongs to the Dps family
G6Z49_RS04380	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
G6Z49_RS04385	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G6Z49_RS04390	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G6Z49_RS04395	COG1845	cytochrome c oxidase, subunit III
G6Z49_RS04415	COG1666	GTP binding
G6Z49_RS04425	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS04435	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
G6Z49_RS04445	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G6Z49_RS04450	COG0746	molybdenum cofactor guanylyltransferase activity
G6Z49_RS04455	COG0303	'Molybdopterin
G6Z49_RS04460	COG0521	Mo-molybdopterin cofactor biosynthetic process
G6Z49_RS04475	COG0315	cyclic pyranopterin monophosphate synthase activity
G6Z49_RS04485	COG0678	peroxiredoxin activity
G6Z49_RS04495	COG0697	spore germination
G6Z49_RS04500	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
G6Z49_RS04540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G6Z49_RS04545	COG1702	phosphate starvation-inducible protein PhoH
G6Z49_RS04550	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
G6Z49_RS04555	COG4535	Mg2 and Co2 transporter CorC
G6Z49_RS04560	COG0815	Transfers the fatty acyl group on membrane lipoproteins
G6Z49_RS04565	COG0667	Aldo Keto reductase
G6Z49_RS04585	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G6Z49_RS04590	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G6Z49_RS04595	COG1862	Preprotein translocase
G6Z49_RS04600	COG0343	queuine tRNA-ribosyltransferase activity
G6Z49_RS04605	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
G6Z49_RS04610	COG2027	D-alanyl-D-alanine carboxypeptidase
G6Z49_RS04615	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G6Z49_RS04620	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G6Z49_RS04620	COG1648	precorrin-2 dehydrogenase activity
G6Z49_RS04630	COG4575	ribosome binding
G6Z49_RS04655	COG0318	PFAM AMP-dependent synthetase and ligase
G6Z49_RS04670	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
G6Z49_RS04675	COG0741	lytic transglycosylase activity
G6Z49_RS04680	COG0436	Aminotransferase
G6Z49_RS04685	COG0281	malic enzyme
G6Z49_RS04685	COG0280	phosphate acetyltransferase
G6Z49_RS04700	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G6Z49_RS04705	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G6Z49_RS04710	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G6Z49_RS04715	COG0126	phosphoglycerate kinase activity
G6Z49_RS04755	COG4592	Periplasmic binding protein
G6Z49_RS04765	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G6Z49_RS04780	COG0625	glutathione transferase activity
G6Z49_RS04815	COG0306	phosphate transporter
G6Z49_RS04820	COG0521	Mo-molybdopterin cofactor biosynthetic process
G6Z49_RS04830	COG0739	heme binding
G6Z49_RS04840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G6Z49_RS04845	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS04855	COG0583	DNA-binding transcription factor activity
G6Z49_RS04865	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G6Z49_RS04870	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G6Z49_RS04885	COG0405	Gamma-glutamyltransferase
G6Z49_RS04900	COG1301	dicarboxylic acid transport
G6Z49_RS04910	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
G6Z49_RS04915	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
G6Z49_RS04920	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
G6Z49_RS04925	COG0009	L-threonylcarbamoyladenylate synthase
G6Z49_RS04935	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G6Z49_RS04950	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
G6Z49_RS04960	COG1960	acyl-CoA dehydrogenase activity
G6Z49_RS04965	COG1960	acyl-CoA dehydrogenase activity
G6Z49_RS04980	COG1960	acyl-CoA dehydrogenase activity
G6Z49_RS04985	COG0028	Belongs to the TPP enzyme family
G6Z49_RS04990	COG0583	DNA-binding transcription factor activity
G6Z49_RS04995	COG4974	Belongs to the 'phage' integrase family
G6Z49_RS05000	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G6Z49_RS05005	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
G6Z49_RS05015	COG1686	Belongs to the peptidase S11 family
G6Z49_RS05040	COG1074	ATP-dependent DNA helicase activity
G6Z49_RS05050	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G6Z49_RS05055	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
G6Z49_RS05065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6Z49_RS05070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G6Z49_RS05080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6Z49_RS05085	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G6Z49_RS05090	COG0505	Belongs to the CarA family
G6Z49_RS05095	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G6Z49_RS05105	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS05125	COG2233	PERMEase
G6Z49_RS05130	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G6Z49_RS05140	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
G6Z49_RS05145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G6Z49_RS05155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G6Z49_RS05165	COG0248	Ppx GppA phosphatase
G6Z49_RS05170	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
G6Z49_RS05195	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G6Z49_RS05225	COG3963	phosphatidate phosphatase activity
G6Z49_RS05235	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G6Z49_RS05240	COG0436	Aminotransferase
G6Z49_RS05255	COG0765	amino acid transport
G6Z49_RS05260	COG1126	abc transporter atp-binding protein
G6Z49_RS05270	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
G6Z49_RS05275	COG2199	diguanylate cyclase activity
G6Z49_RS05275	COG2203	Gaf domain
G6Z49_RS05280	COG0154	amidase activity
G6Z49_RS05290	COG1024	Enoyl-CoA hydratase
G6Z49_RS05295	COG2186	Transcriptional regulator
G6Z49_RS05300	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6Z49_RS05305	COG0154	amidase activity
G6Z49_RS05310	COG2814	Major facilitator Superfamily
G6Z49_RS05320	COG4774	siderophore transport
G6Z49_RS05345	COG1024	Enoyl-CoA hydratase
G6Z49_RS05350	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6Z49_RS05360	COG1024	Enoyl-CoA hydratase
G6Z49_RS05365	COG0318	PFAM AMP-dependent synthetase and ligase
G6Z49_RS05370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G6Z49_RS05385	COG0633	Ferredoxin
G6Z49_RS05425	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS05435	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
G6Z49_RS05440	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS05445	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G6Z49_RS05455	COG3842	ATPase activity
G6Z49_RS05495	COG0243	molybdopterin cofactor binding
G6Z49_RS05520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G6Z49_RS05555	COG0598	Magnesium transport protein CorA
G6Z49_RS05575	COG4191	Histidine kinase
G6Z49_RS05580	COG4566	intracellular signal transduction
G6Z49_RS05585	COG0129	dihydroxy-acid dehydratase activity
G6Z49_RS05590	COG1012	belongs to the aldehyde dehydrogenase family
G6Z49_RS05620	COG2186	Transcriptional regulator
G6Z49_RS05640	COG4948	Mandelate Racemase Muconate Lactonizing
G6Z49_RS05655	COG0583	DNA-binding transcription factor activity
G6Z49_RS05670	COG1802	Transcriptional regulator
G6Z49_RS05685	COG3246	L-lysine catabolic process to acetate
G6Z49_RS05720	COG1136	(ABC) transporter
G6Z49_RS05730	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G6Z49_RS05750	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS05755	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
G6Z49_RS05775	COG0601	transmembrane transport
G6Z49_RS05780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6Z49_RS05785	COG4172	Belongs to the ABC transporter superfamily
G6Z49_RS05790	COG0747	negative chemotaxis
G6Z49_RS05800	COG0583	DNA-binding transcription factor activity
G6Z49_RS05835	COG3307	-O-antigen
G6Z49_RS05845	COG1215	transferase activity, transferring glycosyl groups
G6Z49_RS05860	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G6Z49_RS05905	COG0662	Cupin 2, conserved barrel domain protein
G6Z49_RS05905	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
G6Z49_RS05920	COG2894	cell division
G6Z49_RS05925	COG1215	transferase activity, transferring glycosyl groups
G6Z49_RS05930	COG1215	transferase activity, transferring glycosyl groups
G6Z49_RS05935	COG1215	transferase activity, transferring glycosyl groups
G6Z49_RS05940	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
G6Z49_RS05945	COG0457	Tetratricopeptide repeat
G6Z49_RS05970	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G6Z49_RS05980	COG2837	iron assimilation
G6Z49_RS06000	COG0500	methyltransferase
G6Z49_RS06010	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
G6Z49_RS06025	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G6Z49_RS06030	COG0671	phosphoesterase, PA-phosphatase related
G6Z49_RS06050	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G6Z49_RS06055	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G6Z49_RS06060	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G6Z49_RS06065	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G6Z49_RS06070	COG0649	NAD binding
G6Z49_RS06075	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
G6Z49_RS06085	COG1034	ATP synthesis coupled electron transport
G6Z49_RS06090	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
G6Z49_RS06095	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G6Z49_RS06105	COG0713	ATP synthesis coupled electron transport
G6Z49_RS06120	COG1007	ATP synthesis coupled electron transport
G6Z49_RS06130	COG0560	Phosphoserine phosphatase
G6Z49_RS06135	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G6Z49_RS06140	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
G6Z49_RS06145	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G6Z49_RS06150	COG2207	Transcriptional regulator
G6Z49_RS06155	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G6Z49_RS06160	COG0450	alkyl hydroperoxide reductase
G6Z49_RS06165	COG2205	protein histidine kinase activity
G6Z49_RS06170	COG0745	RESPONSE REGULATOR receiver
G6Z49_RS06175	COG1214	PFAM Peptidase M22, glycoprotease
G6Z49_RS06180	COG1573	uracil-dna glycosylase
G6Z49_RS06185	COG0477	Major facilitator Superfamily
G6Z49_RS06190	COG1196	nuclear chromosome segregation
G6Z49_RS06200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G6Z49_RS06205	COG1126	abc transporter atp-binding protein
G6Z49_RS06210	COG0765	amino acid transport
G6Z49_RS06215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6Z49_RS06220	COG0477	Major facilitator Superfamily
G6Z49_RS06225	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G6Z49_RS06235	COG2917	probably involved in intracellular septation
G6Z49_RS06240	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G6Z49_RS06245	COG1122	ATPase activity
G6Z49_RS06250	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
G6Z49_RS06255	COG1268	BioY protein
G6Z49_RS06280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G6Z49_RS06310	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G6Z49_RS06315	COG2878	Part of a membrane complex involved in electron transport
G6Z49_RS06330	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
G6Z49_RS06335	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
G6Z49_RS06340	COG0251	oxidation-reduction process
G6Z49_RS06350	COG3228	Belongs to the MtfA family
G6Z49_RS06355	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G6Z49_RS06365	COG0133	tryptophan synthase activity
G6Z49_RS06370	COG0159	tryptophan synthase activity
G6Z49_RS06375	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
G6Z49_RS06380	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
G6Z49_RS06385	COG1530	ribonuclease E activity
G6Z49_RS06390	COG0564	pseudouridine synthase activity
G6Z49_RS06395	COG0546	phosphoglycolate phosphatase activity
G6Z49_RS06400	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G6Z49_RS06405	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
G6Z49_RS06410	COG3023	N-Acetylmuramoyl-L-alanine amidase
G6Z49_RS06420	COG0424	maF-like protein
G6Z49_RS06425	COG1399	metal-binding, possibly nucleic acid-binding protein
G6Z49_RS06430	COG0333	Belongs to the bacterial ribosomal protein bL32 family
G6Z49_RS06440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G6Z49_RS06445	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G6Z49_RS06450	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS06455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G6Z49_RS06460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G6Z49_RS06485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G6Z49_RS06490	COG0481	GTPase activity
G6Z49_RS06495	COG0681	Belongs to the peptidase S26 family
G6Z49_RS06500	COG0571	ribonuclease III activity
G6Z49_RS06505	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G6Z49_RS06510	COG1381	Involved in DNA repair and RecF pathway recombination
G6Z49_RS06530	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G6Z49_RS06540	COG0583	DNA-binding transcription factor activity
G6Z49_RS06555	COG0218	Necessary for normal cell division and for the maintenance of normal septation
G6Z49_RS06560	COG0583	DNA-binding transcription factor activity
G6Z49_RS06590	COG0791	NLP P60 protein
G6Z49_RS06595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G6Z49_RS06600	COG3193	protein, possibly involved in utilization of glycolate and propanediol
G6Z49_RS06610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G6Z49_RS06615	COG0697	spore germination
G6Z49_RS06620	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
G6Z49_RS06655	COG1446	asparaginase
G6Z49_RS06660	COG4172	Belongs to the ABC transporter superfamily
G6Z49_RS06665	COG0747	negative chemotaxis
G6Z49_RS06670	COG0601	transmembrane transport
G6Z49_RS06675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6Z49_RS06695	COG0504	CTP synthase activity
G6Z49_RS06705	COG0148	phosphopyruvate hydratase activity
G6Z49_RS06750	COG1473	amidohydrolase
G6Z49_RS06760	COG0626	cystathionine gamma-synthase activity
G6Z49_RS06770	COG2011	ABC-type metal ion transport system permease component
G6Z49_RS06780	COG0583	DNA-binding transcription factor activity
G6Z49_RS06815	COG0039	L-malate dehydrogenase activity
G6Z49_RS06820	COG2188	Transcriptional regulator
G6Z49_RS06825	COG2009	succinate dehydrogenase
G6Z49_RS06830	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
G6Z49_RS06835	COG1053	succinate dehydrogenase
G6Z49_RS06840	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G6Z49_RS06845	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
G6Z49_RS06850	COG0372	Belongs to the citrate synthase family
G6Z49_RS06895	COG3210	domain, Protein
G6Z49_RS06900	COG2831	hemolysin activation secretion protein
G6Z49_RS06915	COG4608	Belongs to the ABC transporter superfamily
G6Z49_RS06920	COG0444	Belongs to the ABC transporter superfamily
G6Z49_RS06925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6Z49_RS06930	COG0601	transmembrane transport
G6Z49_RS06945	COG3842	ATPase activity
G6Z49_RS06955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G6Z49_RS06960	COG1840	ABC-type Fe3 transport system, periplasmic component
G6Z49_RS06965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6Z49_RS06985	COG3128	pkhd-type hydroxylase
G6Z49_RS06990	COG4774	siderophore transport
G6Z49_RS06995	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
G6Z49_RS06995	COG3210	domain, Protein
G6Z49_RS06995	COG3064	Membrane
G6Z49_RS06995	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
G6Z49_RS06995	COG3210	domain, Protein
G6Z49_RS06995	COG3064	Membrane
G6Z49_RS07000	COG0280	phosphate acetyltransferase
G6Z49_RS07000	COG0281	malic enzyme
G6Z49_RS07010	COG1297	OPT oligopeptide transporter protein
G6Z49_RS07015	COG0567	Dehydrogenase, E1 component
G6Z49_RS07020	COG0508	dehydrogenase complex catalyzes the overall conversion of
G6Z49_RS07025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G6Z49_RS07030	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
G6Z49_RS07035	COG1595	DNA-templated transcription, initiation
G6Z49_RS07040	COG3712	iron ion homeostasis
G6Z49_RS07045	COG4774	siderophore transport
G6Z49_RS07075	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
G6Z49_RS07085	COG2183	response to ionizing radiation
G6Z49_RS07090	COG1199	ATP-dependent helicase activity
G6Z49_RS07105	COG0564	pseudouridine synthase activity
G6Z49_RS07115	COG3243	poly(R)-hydroxyalkanoic acid synthase
G6Z49_RS07120	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS07125	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
G6Z49_RS07140	COG0672	)-iron permease
G6Z49_RS07165	COG3237	CsbD-like
G6Z49_RS07170	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G6Z49_RS07170	COG0189	ligase activity
G6Z49_RS07175	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G6Z49_RS07175	COG0189	ligase activity
G6Z49_RS07180	COG1132	(ABC) transporter
G6Z49_RS07195	COG2833	Protein of unknown function (DUF455)
G6Z49_RS07200	COG2951	lytic endotransglycosylase activity
G6Z49_RS07220	COG3706	GGDEF domain
G6Z49_RS07230	COG0586	Pfam SNARE associated Golgi protein
G6Z49_RS07240	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G6Z49_RS07255	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G6Z49_RS07260	COG2197	response regulator
G6Z49_RS07265	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G6Z49_RS07270	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G6Z49_RS07285	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G6Z49_RS07290	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G6Z49_RS07295	COG1764	response to oxidative stress
G6Z49_RS07300	COG2423	ornithine cyclodeaminase activity
G6Z49_RS07310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6Z49_RS07315	COG0765	amino acid transport
G6Z49_RS07320	COG0765	amino acid transport
G6Z49_RS07325	COG1126	abc transporter atp-binding protein
G6Z49_RS07330	COG0756	dUTP diphosphatase activity
G6Z49_RS07350	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G6Z49_RS07355	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G6Z49_RS07360	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G6Z49_RS07365	COG0196	riboflavin kinase activity
G6Z49_RS07370	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G6Z49_RS07375	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G6Z49_RS07375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G6Z49_RS07390	COG0210	DNA helicase
G6Z49_RS07410	COG0601	transmembrane transport
G6Z49_RS07415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6Z49_RS07420	COG0747	negative chemotaxis
G6Z49_RS07425	COG0402	S-adenosylhomocysteine deaminase activity
G6Z49_RS07430	COG0444	Belongs to the ABC transporter superfamily
G6Z49_RS07435	COG4608	Belongs to the ABC transporter superfamily
G6Z49_RS07450	COG4771	TonB-dependent receptor
G6Z49_RS07465	COG0488	(ABC) transporter
G6Z49_RS07470	COG2890	protein-(glutamine-N5) methyltransferase activity
G6Z49_RS07475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G6Z49_RS07480	COG2171	N-acyltransferase activity
G6Z49_RS07495	COG1278	Cold shock
G6Z49_RS07500	COG3042	response to heat
G6Z49_RS07510	COG1278	Cold shock
G6Z49_RS07520	COG1278	Cold shock
G6Z49_RS07530	COG0544	peptidyl-prolyl cis-trans isomerase activity
G6Z49_RS07535	COG0740	serine-type endopeptidase activity
G6Z49_RS07540	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
G6Z49_RS07545	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G6Z49_RS07550	COG0583	DNA-binding transcription factor activity
G6Z49_RS07555	COG2031	fatty acid transporter
G6Z49_RS07565	COG2423	ornithine cyclodeaminase activity
G6Z49_RS07570	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G6Z49_RS07580	COG0556	nucleotide-excision repair
G6Z49_RS07585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G6Z49_RS07595	COG1104	cysteine desulfurase activity
G6Z49_RS07600	COG0822	iron-sulfur transferase activity
G6Z49_RS07605	COG0316	Belongs to the HesB IscA family
G6Z49_RS07610	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
G6Z49_RS07615	COG0443	Heat shock 70 kDa protein
G6Z49_RS07620	COG0633	Ferredoxin
G6Z49_RS07625	COG2975	iron-sulfur cluster assembly
G6Z49_RS07645	COG1803	Methylglyoxal synthase
G6Z49_RS07655	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G6Z49_RS07660	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS07670	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G6Z49_RS07685	COG1136	(ABC) transporter
G6Z49_RS07730	COG0613	PHP domain protein
G6Z49_RS07740	COG0047	phosphoribosylformylglycinamidine synthase activity
G6Z49_RS07740	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G6Z49_RS07760	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS07795	COG0519	Catalyzes the synthesis of GMP from XMP
G6Z49_RS07795	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G6Z49_RS07820	COG4691	Plasmid stability protein
G6Z49_RS07855	COG0798	PFAM Bile acid sodium symporter
G6Z49_RS07910	COG0583	DNA-binding transcription factor activity
G6Z49_RS08025	COG2824	Alkylphosphonate utilization operon protein PhnA
G6Z49_RS08030	COG0210	DNA helicase
G6Z49_RS08050	COG0583	DNA-binding transcription factor activity
G6Z49_RS08065	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS08070	COG0183	Belongs to the thiolase family
G6Z49_RS08095	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS08100	COG2030	dehydratase
G6Z49_RS08105	COG1024	Enoyl-CoA hydratase
G6Z49_RS08120	COG3273	potassium ion transport
G6Z49_RS08120	COG0471	metal ion transport
G6Z49_RS08125	COG1309	transcriptional regulator
G6Z49_RS08135	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS08140	COG1960	acyl-CoA dehydrogenase activity
G6Z49_RS08145	COG1960	acyl-CoA dehydrogenase activity
G6Z49_RS08150	COG1024	Enoyl-CoA hydratase
G6Z49_RS08160	COG1024	Enoyl-CoA hydratase
G6Z49_RS08175	COG0583	DNA-binding transcription factor activity
G6Z49_RS08210	COG0488	(ABC) transporter
G6Z49_RS08225	COG1024	Enoyl-CoA hydratase
G6Z49_RS08240	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G6Z49_RS08245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6Z49_RS08280	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS08285	COG0596	Alpha beta hydrolase
G6Z49_RS08295	COG1024	Enoyl-CoA hydratase
G6Z49_RS08305	COG2207	Transcriptional regulator
G6Z49_RS08310	COG4771	TonB-dependent receptor
G6Z49_RS08325	COG2814	Major facilitator Superfamily
G6Z49_RS08335	COG0583	DNA-binding transcription factor activity
G6Z49_RS08340	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS08365	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
G6Z49_RS08370	COG0688	phosphatidylethanolamine metabolic process
G6Z49_RS08375	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
G6Z49_RS08380	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G6Z49_RS08400	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G6Z49_RS08405	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G6Z49_RS08410	COG2207	Transcriptional regulator
G6Z49_RS08410	COG1917	Cupin 2, conserved barrel domain protein
G6Z49_RS08425	COG1846	Transcriptional regulator
G6Z49_RS08430	COG2365	Tyrosine phosphatase family
G6Z49_RS08455	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G6Z49_RS08480	COG0583	DNA-binding transcription factor activity
G6Z49_RS08485	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS08490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G6Z49_RS08500	COG3135	benzoate transporter
G6Z49_RS08510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6Z49_RS08515	COG1960	acyl-CoA dehydrogenase activity
G6Z49_RS08535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6Z49_RS08545	COG0583	DNA-binding transcription factor activity
G6Z49_RS08555	COG0351	phosphomethylpyrimidine kinase
G6Z49_RS08560	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
G6Z49_RS08580	COG0456	acetyltransferase
G6Z49_RS08600	COG0583	DNA-binding transcription factor activity
G6Z49_RS08615	COG2814	Major facilitator Superfamily
G6Z49_RS08625	COG4585	Histidine kinase
G6Z49_RS08660	COG0653	protein targeting
G6Z49_RS08665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G6Z49_RS08680	COG2207	Transcriptional regulator
G6Z49_RS08685	COG2807	transmembrane transport
G6Z49_RS08710	COG2814	Major facilitator Superfamily
G6Z49_RS08715	COG0583	DNA-binding transcription factor activity
G6Z49_RS08725	COG1522	sequence-specific DNA binding
G6Z49_RS08765	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G6Z49_RS08795	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
G6Z49_RS08800	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
G6Z49_RS08805	COG0390	transport system, permease component
G6Z49_RS08815	COG0583	DNA-binding transcription factor activity
G6Z49_RS08825	COG0477	Major facilitator Superfamily
G6Z49_RS08830	COG0500	methyltransferase
G6Z49_RS08835	COG1418	mRNA catabolic process
G6Z49_RS08850	COG0424	maF-like protein
G6Z49_RS08855	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
G6Z49_RS08860	COG0799	negative regulation of ribosome biogenesis
G6Z49_RS08865	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
G6Z49_RS08870	COG0408	coproporphyrinogen oxidase activity
G6Z49_RS08875	COG0151	Belongs to the GarS family
G6Z49_RS08880	COG0217	transcriptional regulatory protein
G6Z49_RS08885	COG0433	COG0433 Predicted ATPase
G6Z49_RS08890	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G6Z49_RS08900	COG1012	belongs to the aldehyde dehydrogenase family
G6Z49_RS08925	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G6Z49_RS08935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6Z49_RS08940	COG0601	transmembrane transport
G6Z49_RS08945	COG0747	negative chemotaxis
G6Z49_RS08960	COG0473	3-isopropylmalate dehydrogenase activity
G6Z49_RS08965	COG1335	isochorismatase
G6Z49_RS08975	COG0583	DNA-binding transcription factor activity
G6Z49_RS08985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6Z49_RS08990	COG1335	isochorismatase
G6Z49_RS09025	COG2003	Belongs to the UPF0758 family
G6Z49_RS09060	COG2271	Major facilitator Superfamily
G6Z49_RS09090	COG0501	Belongs to the peptidase M48B family
G6Z49_RS09100	COG0789	Transcriptional regulator
G6Z49_RS09120	COG0745	RESPONSE REGULATOR receiver
G6Z49_RS09125	COG4232	protein-disulfide reductase activity
G6Z49_RS09135	COG0730	response to heat
G6Z49_RS09145	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
G6Z49_RS09150	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
G6Z49_RS09155	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G6Z49_RS09175	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G6Z49_RS09190	COG0678	peroxiredoxin activity
G6Z49_RS09190	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G6Z49_RS09200	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
G6Z49_RS09205	COG0584	glycerophosphoryl diester phosphodiesterase
G6Z49_RS09210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G6Z49_RS09220	COG4181	ATPase activity
G6Z49_RS09230	COG3210	domain, Protein
G6Z49_RS09230	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
G6Z49_RS09230	COG3210	domain, Protein
G6Z49_RS09230	COG3064	Membrane
G6Z49_RS09230	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
G6Z49_RS09230	COG3064	Membrane
G6Z49_RS09235	COG3121	Chaperone
G6Z49_RS09240	COG3188	usher protein
G6Z49_RS09255	COG2831	hemolysin activation secretion protein
G6Z49_RS09285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G6Z49_RS09290	COG1758	RNA polymerase activity
G6Z49_RS09295	COG0194	GDP metabolic process
G6Z49_RS09300	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS09305	COG0791	NLP P60 protein
G6Z49_RS09315	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G6Z49_RS09320	COG1561	YicC-like family, N-terminal region
G6Z49_RS09325	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
G6Z49_RS09330	COG2079	MmgE PrpD family protein
G6Z49_RS09335	COG1960	acyl-CoA dehydrogenase activity
G6Z49_RS09345	COG0840	transmembrane signaling receptor activity
G6Z49_RS09350	COG4943	cyclic-guanylate-specific phosphodiesterase activity
G6Z49_RS09355	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
G6Z49_RS09360	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G6Z49_RS09365	COG0174	glutamine synthetase
G6Z49_RS09370	COG3852	Histidine kinase
G6Z49_RS09375	COG2204	response regulator
G6Z49_RS09405	COG0583	DNA-binding transcription factor activity
G6Z49_RS09410	COG1741	Belongs to the pirin family
G6Z49_RS09415	COG1741	Belongs to the pirin family
G6Z49_RS09425	COG4149	molybdate abc transporter
G6Z49_RS09430	COG1840	ABC-type Fe3 transport system, periplasmic component
G6Z49_RS09445	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G6Z49_RS09450	COG0583	DNA-binding transcription factor activity
G6Z49_RS09455	COG0783	Belongs to the Dps family
G6Z49_RS09470	COG3842	ATPase activity
G6Z49_RS09480	COG1175	transmembrane transport
G6Z49_RS09485	COG1653	transport
G6Z49_RS09495	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
G6Z49_RS09505	COG0559	Belongs to the binding-protein-dependent transport system permease family
G6Z49_RS09525	COG1794	racemase activity, acting on amino acids and derivatives
G6Z49_RS09530	COG0625	glutathione transferase activity
G6Z49_RS09535	COG0697	spore germination
G6Z49_RS09540	COG2363	Small membrane protein
G6Z49_RS09555	COG1464	Belongs to the NlpA lipoprotein family
G6Z49_RS09560	COG1304	FMN binding
G6Z49_RS09565	COG0688	phosphatidylethanolamine metabolic process
G6Z49_RS09575	COG0028	Belongs to the TPP enzyme family
G6Z49_RS09580	COG2186	Transcriptional regulator
G6Z49_RS09585	COG3189	MarR family transcriptional regulator
G6Z49_RS09595	COG2205	protein histidine kinase activity
G6Z49_RS09595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6Z49_RS09600	COG2197	response regulator
G6Z49_RS09605	COG2203	Gaf domain
G6Z49_RS09605	COG3706	GGDEF domain
G6Z49_RS09605	COG4251	negative regulation of phosphorylation
G6Z49_RS09605	COG5001	Diguanylate cyclase
G6Z49_RS09615	COG1253	flavin adenine dinucleotide binding
G6Z49_RS09630	COG2200	EAL domain
G6Z49_RS09645	COG0765	amino acid transport
G6Z49_RS09650	COG1126	abc transporter atp-binding protein
G6Z49_RS09690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G6Z49_RS09705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G6Z49_RS09725	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G6Z49_RS09730	COG0747	negative chemotaxis
G6Z49_RS09740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6Z49_RS09745	COG4172	Belongs to the ABC transporter superfamily
G6Z49_RS09750	COG0640	Transcriptional regulator
G6Z49_RS09755	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
G6Z49_RS09770	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS09775	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G6Z49_RS09780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G6Z49_RS09785	COG1802	Transcriptional regulator
G6Z49_RS09800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6Z49_RS09805	COG1024	Enoyl-CoA hydratase
G6Z49_RS09810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6Z49_RS09815	COG1024	Enoyl-CoA hydratase
G6Z49_RS09820	COG1464	Belongs to the NlpA lipoprotein family
G6Z49_RS09845	COG0251	oxidation-reduction process
G6Z49_RS09865	COG1113	amino acid transport
G6Z49_RS09870	COG2986	histidine ammonia-lyase
G6Z49_RS09875	COG1234	tRNA 3'-trailer cleavage
G6Z49_RS09890	COG4585	Histidine kinase
G6Z49_RS09895	COG1024	Enoyl-CoA hydratase
G6Z49_RS09900	COG1024	Enoyl-CoA hydratase
G6Z49_RS09905	COG0318	PFAM AMP-dependent synthetase and ligase
G6Z49_RS09910	COG1960	acyl-CoA dehydrogenase activity
G6Z49_RS09920	COG4771	TonB-dependent receptor
G6Z49_RS09925	COG0583	DNA-binding transcription factor activity
G6Z49_RS09930	COG0154	amidase activity
G6Z49_RS09940	COG1522	sequence-specific DNA binding
G6Z49_RS09950	COG0251	oxidation-reduction process
G6Z49_RS09955	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G6Z49_RS09985	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G6Z49_RS09995	COG1116	anion transmembrane transporter activity
G6Z49_RS10000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6Z49_RS10010	COG0604	alcohol dehydrogenase
G6Z49_RS10020	COG0318	PFAM AMP-dependent synthetase and ligase
G6Z49_RS10035	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
G6Z49_RS10040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6Z49_RS10045	COG2900	Belongs to the SlyX family
G6Z49_RS10050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G6Z49_RS10075	COG1960	acyl-CoA dehydrogenase activity
G6Z49_RS10080	COG1960	acyl-CoA dehydrogenase activity
G6Z49_RS10095	COG1024	Enoyl-CoA hydratase
G6Z49_RS10110	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G6Z49_RS10110	COG0519	Catalyzes the synthesis of GMP from XMP
G6Z49_RS10135	COG3608	succinylglutamate desuccinylase aspartoacylase
G6Z49_RS10155	COG3258	Cytochrome c
G6Z49_RS10170	COG2733	membrane
G6Z49_RS10175	COG0179	Fumarylacetoacetate (FAA) hydrolase
G6Z49_RS10210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G6Z49_RS10215	COG1129	ABC transporter
G6Z49_RS10215	COG0842	Transport permease protein
G6Z49_RS10220	COG0842	Transport permease protein
G6Z49_RS10230	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS10250	COG1393	Belongs to the ArsC family
G6Z49_RS10255	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6Z49_RS10260	COG0415	Belongs to the DNA photolyase family
G6Z49_RS10280	COG0386	Belongs to the glutathione peroxidase family
G6Z49_RS10295	COG0095	Lipoate-protein ligase
G6Z49_RS10305	COG0740	serine-type endopeptidase activity
G6Z49_RS10320	COG0625	glutathione transferase activity
G6Z49_RS10330	COG0024	Methionine aminopeptidase
G6Z49_RS10340	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G6Z49_RS10350	COG0084	hydrolase, TatD family'
G6Z49_RS10355	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G6Z49_RS10360	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G6Z49_RS10365	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G6Z49_RS10370	COG0354	folic acid binding
G6Z49_RS10385	COG1250	3-hydroxyacyl-CoA dehydrogenase
G6Z49_RS10385	COG1024	Enoyl-CoA hydratase
G6Z49_RS10390	COG1960	acyl-CoA dehydrogenase activity
G6Z49_RS10395	COG2914	Belongs to the UPF0125 (RnfH) family
G6Z49_RS10400	COG2867	negative regulation of translational initiation
G6Z49_RS10405	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G6Z49_RS10425	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
G6Z49_RS10430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G6Z49_RS10435	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G6Z49_RS10440	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G6Z49_RS10450	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G6Z49_RS10455	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G6Z49_RS10460	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
G6Z49_RS10465	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G6Z49_RS10470	COG0750	zinc metalloprotease
G6Z49_RS10475	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
G6Z49_RS10480	COG0575	Belongs to the CDS family
G6Z49_RS10485	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G6Z49_RS10490	COG0233	cytoplasmic translational termination
G6Z49_RS10495	COG0528	UMP kinase activity
G6Z49_RS10500	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
G6Z49_RS10505	COG0052	Belongs to the universal ribosomal protein uS2 family
G6Z49_RS10510	COG0024	Methionine aminopeptidase
G6Z49_RS10515	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
G6Z49_RS10520	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
G6Z49_RS10530	COG1286	toxin biosynthetic process
G6Z49_RS10540	COG0285	dihydrofolate synthase activity
G6Z49_RS10580	COG1677	Flagellar hook-basal body complex protein FliE
G6Z49_RS10590	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G6Z49_RS10595	COG1317	bacterial-type flagellum organization
G6Z49_RS10605	COG2882	bacterial-type flagellum organization
G6Z49_RS10615	COG1580	Controls the rotational direction of flagella during chemotaxis
G6Z49_RS10640	COG1987	bacterial-type flagellum assembly
G6Z49_RS10650	COG0840	transmembrane signaling receptor activity
G6Z49_RS10655	COG0840	transmembrane signaling receptor activity
G6Z49_RS10665	COG1256	bacterial-type flagellum assembly
G6Z49_RS10675	COG1706	bacterial-type flagellum-dependent cell motility
G6Z49_RS10690	COG4787	bacterial-type flagellum-dependent cell motility
G6Z49_RS10695	COG1749	Flagellar hook protein flgE
G6Z49_RS10705	COG1558	bacterial-type flagellum-dependent cell motility
G6Z49_RS10745	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
G6Z49_RS10750	COG0745	RESPONSE REGULATOR receiver
G6Z49_RS10755	COG2201	protein-glutamate methylesterase activity
G6Z49_RS10760	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
G6Z49_RS10765	COG0840	transmembrane signaling receptor activity
G6Z49_RS10780	COG0745	RESPONSE REGULATOR receiver
G6Z49_RS10785	COG1360	Flagellar Motor Protein
G6Z49_RS10805	COG1191	sigma factor activity
G6Z49_RS10815	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G6Z49_RS10815	COG4797	methyltransferase
G6Z49_RS10820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G6Z49_RS10825	COG0508	dehydrogenase complex catalyzes the overall conversion of
G6Z49_RS10830	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
G6Z49_RS10840	COG4566	intracellular signal transduction
G6Z49_RS10845	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G6Z49_RS10890	COG1187	pseudouridine synthase activity
G6Z49_RS10895	COG3161	chorismate lyase activity
G6Z49_RS10910	COG4172	Belongs to the ABC transporter superfamily
G6Z49_RS10920	COG0601	transmembrane transport
G6Z49_RS10925	COG0747	negative chemotaxis
G6Z49_RS10935	COG0583	DNA-binding transcription factor activity
G6Z49_RS10960	COG0668	transmembrane transport
G6Z49_RS10965	COG0165	Argininosuccinate lyase
G6Z49_RS10970	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
G6Z49_RS10975	COG2252	PERMEase
G6Z49_RS10980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G6Z49_RS10985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G6Z49_RS11015	COG0488	(ABC) transporter
G6Z49_RS11020	COG1619	proteins homologs of microcin C7 resistance protein MccF
G6Z49_RS11025	COG0590	tRNA wobble adenosine to inosine editing
G6Z49_RS11045	COG2212	antiporter activity
G6Z49_RS11050	COG1863	multisubunit Na H antiporter MnhE subunit
G6Z49_RS11055	COG0651	ATP synthesis coupled electron transport
G6Z49_RS11060	COG1006	Multisubunit Na H antiporter MnhC subunit
G6Z49_RS11065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G6Z49_RS11065	COG2111	Na H antiporter
G6Z49_RS11080	COG0420	3'-5' exonuclease activity
G6Z49_RS11085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6Z49_RS11110	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
G6Z49_RS11115	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G6Z49_RS11145	COG0477	Major facilitator Superfamily
G6Z49_RS11155	COG1802	Transcriptional regulator
G6Z49_RS11165	COG0602	queuosine metabolic process
G6Z49_RS11170	COG0720	synthase
G6Z49_RS11180	COG2814	Major facilitator Superfamily
G6Z49_RS11195	COG1289	transmembrane transporter activity
G6Z49_RS11205	COG1566	PFAM secretion protein HlyD family protein
G6Z49_RS11230	COG0587	DNA-directed DNA polymerase activity
G6Z49_RS11235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6Z49_RS11255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G6Z49_RS11325	COG1522	sequence-specific DNA binding
G6Z49_RS11335	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G6Z49_RS11360	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G6Z49_RS11360	COG2010	Cytochrome c
G6Z49_RS11400	COG0384	phenazine biosynthesis protein PhzF
G6Z49_RS11445	COG0776	regulation of translation
G6Z49_RS11450	COG0072	phenylalanine-tRNA ligase activity
G6Z49_RS11450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G6Z49_RS11455	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G6Z49_RS11460	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
G6Z49_RS11465	COG0291	Belongs to the bacterial ribosomal protein bL35 family
G6Z49_RS11475	COG3119	arylsulfatase activity
G6Z49_RS11490	COG0110	maltose O-acetyltransferase activity
G6Z49_RS11520	COG0004	ammonium transporteR
G6Z49_RS11530	COG3008	intermembrane lipid transfer
G6Z49_RS11535	COG2995	paraquat-inducible protein a
G6Z49_RS11540	COG0542	response to heat
G6Z49_RS11545	COG4953	penicillin-binding protein 1C
G6Z49_RS11555	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
G6Z49_RS11560	COG1278	Cold shock
G6Z49_RS11570	COG0183	Belongs to the thiolase family
G6Z49_RS11575	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G6Z49_RS11580	COG1570	exodeoxyribonuclease VII activity
G6Z49_RS11585	COG0811	peptide transport
G6Z49_RS11590	COG0848	biopolymer transport protein
G6Z49_RS11595	COG1663	tetraacyldisaccharide 4'-kinase activity
G6Z49_RS11600	COG2835	tetraacyldisaccharide 4'-kinase activity
G6Z49_RS11605	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
G6Z49_RS11610	COG0563	adenylate kinase activity
G6Z49_RS11620	COG0728	peptidoglycan biosynthetic process
G6Z49_RS11630	COG0268	Binds directly to 16S ribosomal RNA
G6Z49_RS11650	COG2186	Transcriptional regulator
G6Z49_RS11665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G6Z49_RS11675	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G6Z49_RS11690	COG3971	2-oxopent-4-enoate hydratase activity
G6Z49_RS11695	COG3158	transport of potassium into the cell
G6Z49_RS11700	COG0642	Histidine kinase
G6Z49_RS11730	COG0776	regulation of translation
G6Z49_RS11740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G6Z49_RS11745	COG0557	exoribonuclease II activity
G6Z49_RS11780	COG0069	glutamate synthase activity
G6Z49_RS11810	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G6Z49_RS11815	COG0028	Belongs to the TPP enzyme family
G6Z49_RS11825	COG3706	GGDEF domain
G6Z49_RS11830	COG3706	GGDEF domain
G6Z49_RS11840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G6Z49_RS11865	COG3909	cytochrome
G6Z49_RS11875	COG0625	glutathione transferase activity
G6Z49_RS11880	COG0730	response to heat
G6Z49_RS11885	COG0482	sulfurtransferase activity
G6Z49_RS11890	COG0583	DNA-binding transcription factor activity
G6Z49_RS11920	COG0247	lactate metabolic process
G6Z49_RS11925	COG0277	FAD linked oxidase domain protein
G6Z49_RS11930	COG0277	FAD linked oxidase domain protein
G6Z49_RS11935	COG0277	FAD linked oxidase domain protein
G6Z49_RS11940	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G6Z49_RS11945	COG0312	modulator of DNA gyrase
G6Z49_RS11960	COG0308	aminopeptidase N
G6Z49_RS11965	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
G6Z49_RS11985	COG0436	Aminotransferase
G6Z49_RS11990	COG3737	Protein of unknown function (DUF498/DUF598)
G6Z49_RS11995	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G6Z49_RS12000	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
G6Z49_RS12005	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G6Z49_RS12015	COG0305	Participates in initiation and elongation during chromosome replication
G6Z49_RS12025	COG0359	binds to the 23S rRNA
G6Z49_RS12030	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G6Z49_RS12035	COG2965	DNA replication, synthesis of RNA primer
G6Z49_RS12040	COG0360	Binds together with S18 to 16S ribosomal RNA
G6Z49_RS12045	COG3739	integral membrane protein
G6Z49_RS12050	COG1469	GTP cyclohydrolase I activity
G6Z49_RS12060	COG0142	geranyltranstransferase activity
G6Z49_RS12065	COG1722	exodeoxyribonuclease VII activity
G6Z49_RS12075	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS12105	COG0501	Belongs to the peptidase M48B family
G6Z49_RS12130	COG1538	Outer membrane efflux protein
G6Z49_RS12135	COG1566	PFAM secretion protein HlyD family protein
G6Z49_RS12140	COG2814	Major facilitator Superfamily
G6Z49_RS12170	COG1530	ribonuclease E activity
G6Z49_RS12180	COG1132	(ABC) transporter
G6Z49_RS12205	COG0297	glycogen (starch) synthase activity
G6Z49_RS12220	COG0463	Glycosyl transferase, family 2
G6Z49_RS12225	COG0726	polysaccharide deacetylase
G6Z49_RS12230	COG0438	transferase activity, transferring glycosyl groups
G6Z49_RS12245	COG1643	Atp-dependent helicase
G6Z49_RS12250	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G6Z49_RS12250	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
G6Z49_RS12255	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
G6Z49_RS12260	COG0704	Plays a role in the regulation of phosphate uptake
G6Z49_RS12265	COG1960	acyl-CoA dehydrogenase activity
G6Z49_RS12270	COG1322	Protein conserved in bacteria
G6Z49_RS12280	COG2094	Belongs to the DNA glycosylase MPG family
G6Z49_RS12285	COG1393	Belongs to the ArsC family
G6Z49_RS12290	COG1177	transmembrane transport
G6Z49_RS12295	COG1176	ABC-type spermidine putrescine transport system, permease component I
G6Z49_RS12300	COG3842	ATPase activity
G6Z49_RS12310	COG3642	lipopolysaccharide core region biosynthetic process
G6Z49_RS12315	COG0583	DNA-binding transcription factor activity
G6Z49_RS12320	COG0133	tryptophan synthase activity
G6Z49_RS12325	COG0159	tryptophan synthase activity
G6Z49_RS12335	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
G6Z49_RS12340	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G6Z49_RS12370	COG2050	protein possibly involved in aromatic compounds catabolism
G6Z49_RS12375	COG1024	Enoyl-CoA hydratase
G6Z49_RS12385	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G6Z49_RS12390	COG2151	metal-sulfur cluster biosynthetic enzyme
G6Z49_RS12395	COG3396	Phenylacetate-CoA oxygenase
G6Z49_RS12400	COG3460	Phenylacetate-CoA oxygenase
G6Z49_RS12405	COG3396	Phenylacetate-CoA oxygenase
G6Z49_RS12410	COG3327	negative regulation of DNA-templated transcription, initiation
G6Z49_RS12420	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
G6Z49_RS12425	COG0501	Belongs to the peptidase M48B family
G6Z49_RS12430	COG1162	GTPase activity
G6Z49_RS12435	COG3622	Belongs to the hyi family
G6Z49_RS12445	COG0335	large ribosomal subunit rRNA binding
G6Z49_RS12465	COG0450	alkyl hydroperoxide reductase
G6Z49_RS12470	COG1960	acyl-CoA dehydrogenase activity
G6Z49_RS12475	COG2985	domain, Protein
G6Z49_RS12490	COG0123	including yeast histone deacetylase and acetoin utilization protein
G6Z49_RS12495	COG2951	lytic endotransglycosylase activity
G6Z49_RS12510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G6Z49_RS12515	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
G6Z49_RS12520	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
G6Z49_RS12540	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G6Z49_RS12545	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G6Z49_RS12550	COG0287	Prephenate dehydrogenase
G6Z49_RS12555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G6Z49_RS12565	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
G6Z49_RS12580	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G6Z49_RS12620	COG1024	Enoyl-CoA hydratase
G6Z49_RS12625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6Z49_RS12630	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6Z49_RS12635	COG0604	alcohol dehydrogenase
G6Z49_RS12665	COG0583	DNA-binding transcription factor activity
G6Z49_RS12670	COG2755	lipolytic protein G-D-S-L family
G6Z49_RS12670	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G6Z49_RS12675	COG3706	GGDEF domain
G6Z49_RS12685	COG0135	phosphoribosylanthranilate isomerase activity
G6Z49_RS12690	COG0101	tRNA pseudouridine synthase activity
G6Z49_RS12700	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
G6Z49_RS12705	COG0473	3-isopropylmalate dehydrogenase activity
G6Z49_RS12710	COG0066	3-isopropylmalate dehydratase activity
G6Z49_RS12730	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
G6Z49_RS12740	COG2205	protein histidine kinase activity
G6Z49_RS12750	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
G6Z49_RS12755	COG1295	ribonuclease BN
G6Z49_RS12765	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G6Z49_RS12800	COG4964	Belongs to the GSP D family
G6Z49_RS12835	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G6Z49_RS12840	COG1960	acyl-CoA dehydrogenase activity
G6Z49_RS12875	COG0181	hydroxymethylbilane synthase activity
G6Z49_RS12880	COG0861	Integral membrane protein TerC family
G6Z49_RS12885	COG0861	Integral membrane protein TerC family
G6Z49_RS12890	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G6Z49_RS12895	COG0045	succinate-CoA ligase (ADP-forming) activity
G6Z49_RS12905	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
G6Z49_RS12915	COG2137	regulation of response to DNA damage stimulus
G6Z49_RS12920	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G6Z49_RS12930	COG0642	Histidine kinase
G6Z49_RS12940	COG2974	May be involved in recombination
G6Z49_RS12945	COG0540	Belongs to the ATCase OTCase family
G6Z49_RS12975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G6Z49_RS12995	COG0330	HflC and HflK could
G6Z49_RS13000	COG3437	response regulator, receiver
G6Z49_RS13000	COG0784	Response regulator, receiver
G6Z49_RS13055	COG4983	Phage plasmid primase, P4 family domain protein
G6Z49_RS13100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G6Z49_RS13110	COG0828	Belongs to the bacterial ribosomal protein bS21 family
G6Z49_RS13120	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G6Z49_RS13125	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
G6Z49_RS13130	COG0330	HflC and HflK could
G6Z49_RS13135	COG0330	HflC and HflK could
G6Z49_RS13140	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G6Z49_RS13145	COG1923	regulation of RNA biosynthetic process
G6Z49_RS13150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G6Z49_RS13155	COG1160	GTP binding
G6Z49_RS13160	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G6Z49_RS13165	COG2976	Protein conserved in bacteria
G6Z49_RS13170	COG0124	histidyl-tRNA synthetase
G6Z49_RS13185	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G6Z49_RS13190	COG0105	UTP biosynthetic process
G6Z49_RS13195	COG0525	valine-tRNA ligase activity
G6Z49_RS13200	COG0336	Belongs to the RNA methyltransferase TrmD family
G6Z49_RS13205	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G6Z49_RS13210	COG0228	four-way junction DNA binding
G6Z49_RS13215	COG0425	Belongs to the sulfur carrier protein TusA family
G6Z49_RS13220	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G6Z49_RS13270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6Z49_RS13275	COG0543	2 iron, 2 sulfur cluster binding
G6Z49_RS13275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G6Z49_RS13280	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
G6Z49_RS13285	COG2076	Multidrug Resistance protein
G6Z49_RS13290	COG0633	Ferredoxin
G6Z49_RS13290	COG3217	Mosc domain protein beta barrel domain protein
G6Z49_RS13295	COG5285	phytanoyl-CoA dioxygenase
G6Z49_RS13300	COG0662	Cupin 2, conserved barrel domain protein
G6Z49_RS13320	COG2311	Membrane
G6Z49_RS13345	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
G6Z49_RS13365	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
G6Z49_RS13370	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G6Z49_RS13375	COG1760	l-serine dehydratase
G6Z49_RS13380	COG1283	sodium-dependent phosphate transmembrane transporter activity
G6Z49_RS13385	COG0412	Dienelactone hydrolase
G6Z49_RS13415	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G6Z49_RS13420	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G6Z49_RS13425	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G6Z49_RS13430	COG0195	Participates in both transcription termination and antitermination
G6Z49_RS13430	COG2251	uridine kinase activity
G6Z49_RS13435	COG0779	Required for maturation of 30S ribosomal subunits
G6Z49_RS13440	COG1187	pseudouridine synthase activity
G6Z49_RS13445	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G6Z49_RS13455	COG0523	cobalamin synthesis protein
G6Z49_RS13470	COG0625	glutathione transferase activity
G6Z49_RS13475	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G6Z49_RS13485	COG2003	Belongs to the UPF0758 family
G6Z49_RS13490	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
G6Z49_RS13495	COG3483	tryptophan 2,3-dioxygenase activity
G6Z49_RS13500	COG0254	rRNA binding
G6Z49_RS13550	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS13555	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G6Z49_RS13565	COG1562	ergosterol biosynthetic process
G6Z49_RS13570	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
G6Z49_RS13570	COG0493	'glutamate synthase
G6Z49_RS13575	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G6Z49_RS13600	COG1477	protein flavinylation
G6Z49_RS13615	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
G6Z49_RS13620	COG0583	DNA-binding transcription factor activity
G6Z49_RS13625	COG0542	response to heat
G6Z49_RS13630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G6Z49_RS13640	COG0494	nUDIX hydrolase
G6Z49_RS13650	COG0583	DNA-binding transcription factor activity
G6Z49_RS13655	COG3530	Putative quorum-sensing-regulated virulence factor
G6Z49_RS13685	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
G6Z49_RS13695	COG0628	permease
G6Z49_RS13700	COG0842	Transport permease protein
G6Z49_RS13705	COG1131	(ABC) transporter
G6Z49_RS13715	COG0156	8-amino-7-oxononanoate synthase activity
G6Z49_RS13725	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
G6Z49_RS13725	COG4106	trans-aconitate 2-methyltransferase activity
G6Z49_RS13730	COG5006	permease, DMT superfamily
G6Z49_RS13735	COG1522	sequence-specific DNA binding
G6Z49_RS13750	COG0318	PFAM AMP-dependent synthetase and ligase
G6Z49_RS13755	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS13760	COG2224	Isocitrate lyase
G6Z49_RS13765	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
G6Z49_RS13765	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
G6Z49_RS13775	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G6Z49_RS13785	COG1472	Belongs to the glycosyl hydrolase 3 family
G6Z49_RS13790	COG0736	holo-[acyl-carrier-protein] synthase activity
G6Z49_RS13795	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
G6Z49_RS13805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G6Z49_RS13810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G6Z49_RS13815	COG0745	RESPONSE REGULATOR receiver
G6Z49_RS13835	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
G6Z49_RS13840	COG4149	molybdate abc transporter
G6Z49_RS13845	COG0725	ABC transporter, periplasmic molybdate-binding protein
G6Z49_RS13850	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
G6Z49_RS13855	COG4120	Belongs to the binding-protein-dependent transport system permease family
G6Z49_RS13875	COG0318	PFAM AMP-dependent synthetase and ligase
G6Z49_RS13880	COG1024	Enoyl-CoA hydratase
G6Z49_RS13890	COG1802	Transcriptional regulator
G6Z49_RS13905	COG0183	Belongs to the thiolase family
G6Z49_RS13910	COG1960	acyl-CoA dehydrogenase activity
G6Z49_RS13945	COG4175	Glycine betaine
G6Z49_RS13945	COG3448	diguanylate cyclase activity
G6Z49_RS13950	COG4176	ABC-type proline glycine betaine transport system permease component
G6Z49_RS13960	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G6Z49_RS13965	COG2814	Major facilitator Superfamily
G6Z49_RS13970	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G6Z49_RS13975	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G6Z49_RS13995	COG1846	Transcriptional regulator
G6Z49_RS14000	COG2814	Major facilitator Superfamily
G6Z49_RS14005	COG0495	leucyl-tRNA aminoacylation
G6Z49_RS14020	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G6Z49_RS14055	COG0579	oxidoreductase
G6Z49_RS14085	COG0427	acetyl-CoA hydrolase
G6Z49_RS14090	COG0583	DNA-binding transcription factor activity
G6Z49_RS14095	COG3264	Mechanosensitive ion channel
G6Z49_RS14095	COG1511	domain protein
G6Z49_RS14125	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
G6Z49_RS14130	COG3384	dioxygenase
G6Z49_RS14145	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G6Z49_RS14165	COG4172	Belongs to the ABC transporter superfamily
G6Z49_RS14170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6Z49_RS14180	COG0747	negative chemotaxis
G6Z49_RS14190	COG0598	Magnesium transport protein CorA
G6Z49_RS14195	COG0210	DNA helicase
G6Z49_RS14210	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G6Z49_RS14230	COG0483	inositol monophosphate 1-phosphatase activity
G6Z49_RS14235	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G6Z49_RS14245	COG1045	serine acetyltransferase
G6Z49_RS14250	COG0183	Belongs to the thiolase family
G6Z49_RS14255	COG1024	Enoyl-CoA hydratase
G6Z49_RS14255	COG1250	3-hydroxyacyl-CoA dehydrogenase
G6Z49_RS14260	COG1250	3-hydroxyacyl-CoA dehydrogenase
G6Z49_RS14260	COG1024	Enoyl-CoA hydratase
G6Z49_RS14265	COG0183	Belongs to the thiolase family
G6Z49_RS14270	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G6Z49_RS14280	COG1902	pentaerythritol trinitrate reductase activity
G6Z49_RS14285	COG0625	glutathione transferase activity
G6Z49_RS14335	COG0037	tRNA processing
G6Z49_RS14340	COG0825	malonyl-CoA metabolic process
G6Z49_RS14350	COG0215	cysteine-tRNA ligase activity
G6Z49_RS14360	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G6Z49_RS14370	COG1968	undecaprenyl-diphosphatase activity
G6Z49_RS14375	COG1253	flavin adenine dinucleotide binding
G6Z49_RS14385	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
G6Z49_RS14400	COG0668	transmembrane transport
G6Z49_RS14445	COG4771	TonB-dependent receptor
G6Z49_RS14450	COG2205	protein histidine kinase activity
G6Z49_RS14455	COG0745	RESPONSE REGULATOR receiver
G6Z49_RS14460	COG2169	Transcriptional regulator
G6Z49_RS14470	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
G6Z49_RS14475	COG2850	peptidyl-arginine hydroxylation
G6Z49_RS14490	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
G6Z49_RS14495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G6Z49_RS14500	COG1994	Peptidase M50
G6Z49_RS14505	COG0009	L-threonylcarbamoyladenylate synthase
G6Z49_RS14510	COG2321	neutral zinc metallopeptidase
G6Z49_RS14530	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G6Z49_RS14535	COG1475	DNA binding
G6Z49_RS14540	COG3969	phosphoadenosine phosphosulfate
G6Z49_RS14545	COG1238	metal cluster binding
G6Z49_RS14560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G6Z49_RS14590	COG1522	sequence-specific DNA binding
G6Z49_RS14600	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS14605	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
G6Z49_RS14610	COG0642	Histidine kinase
G6Z49_RS14620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G6Z49_RS14625	COG3278	Belongs to the heme-copper respiratory oxidase family
G6Z49_RS14635	COG2863	cytochrome
G6Z49_RS14640	COG3258	Cytochrome c
G6Z49_RS14645	COG2217	Heavy metal translocating P-type atpase
G6Z49_RS14695	COG0583	DNA-binding transcription factor activity
G6Z49_RS14700	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS14710	COG0179	Fumarylacetoacetate (FAA) hydrolase
G6Z49_RS14725	COG1464	Belongs to the NlpA lipoprotein family
G6Z49_RS14750	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS14755	COG4604	ABC transporter, ATP-binding protein
G6Z49_RS14760	COG4605	iron ion homeostasis
G6Z49_RS14765	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G6Z49_RS14770	COG4607	ABC-type enterochelin transport system periplasmic component
G6Z49_RS14780	COG0149	triose-phosphate isomerase activity
G6Z49_RS14785	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS14785	COG3321	synthase
G6Z49_RS14785	COG0604	alcohol dehydrogenase
G6Z49_RS14800	COG4774	siderophore transport
G6Z49_RS14820	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G6Z49_RS14830	COG1185	polyribonucleotide nucleotidyltransferase activity
G6Z49_RS14835	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
G6Z49_RS14845	COG1183	phosphatidylcholine synthase activity
G6Z49_RS14850	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G6Z49_RS14855	COG0440	acetolactate synthase activity
G6Z49_RS14860	COG0028	Belongs to the TPP enzyme family
G6Z49_RS14865	COG1289	transmembrane transporter activity
G6Z49_RS14870	COG3022	response to hydroperoxide
G6Z49_RS14875	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS14885	COG2153	protein acetylation
G6Z49_RS14915	COG1473	amidohydrolase
G6Z49_RS14920	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS14945	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6Z49_RS14950	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G6Z49_RS14955	COG1122	ATPase activity
G6Z49_RS14960	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G6Z49_RS14995	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
G6Z49_RS15000	COG1674	ftsk spoiiie
G6Z49_RS15005	COG0492	ferredoxin-NADP+ reductase activity
G6Z49_RS15010	COG1193	negative regulation of DNA recombination
G6Z49_RS15020	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G6Z49_RS15040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G6Z49_RS15055	COG0612	Peptidase, M16
G6Z49_RS15060	COG0484	heat shock protein binding
G6Z49_RS15065	COG0443	Heat shock 70 kDa protein
G6Z49_RS15075	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G6Z49_RS15085	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
G6Z49_RS15090	COG1420	regulation of RNA biosynthetic process
G6Z49_RS15095	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G6Z49_RS15100	COG0497	DNA recombination
G6Z49_RS15105	COG0735	belongs to the Fur family
G6Z49_RS15110	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G6Z49_RS15135	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
G6Z49_RS15150	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G6Z49_RS15170	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS15190	COG0583	DNA-binding transcription factor activity
G6Z49_RS15210	COG0235	Class ii aldolase
G6Z49_RS15215	COG1309	transcriptional regulator
G6Z49_RS15220	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS15245	COG0583	DNA-binding transcription factor activity
G6Z49_RS15255	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
G6Z49_RS15260	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
G6Z49_RS15265	COG0167	dihydroorotate dehydrogenase activity
G6Z49_RS15280	COG1414	Transcriptional regulator
G6Z49_RS15285	COG1058	Belongs to the CinA family
G6Z49_RS15285	COG1546	Belongs to the CinA family
G6Z49_RS15300	COG0513	Belongs to the DEAD box helicase family
G6Z49_RS15325	COG0429	hydrolase of the alpha beta-hydrolase fold
G6Z49_RS15330	COG4783	chaperone-mediated protein folding
G6Z49_RS15340	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G6Z49_RS15345	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
G6Z49_RS15360	COG0006	proline dipeptidase activity
G6Z49_RS15365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G6Z49_RS15385	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
G6Z49_RS15390	COG0632	four-way junction helicase activity
G6Z49_RS15395	COG1090	epimerase
G6Z49_RS15400	COG2255	four-way junction helicase activity
G6Z49_RS15405	COG0514	ATP-dependent DNA helicase (RecQ)
G6Z49_RS15415	COG0745	RESPONSE REGULATOR receiver
G6Z49_RS15420	COG3290	protein histidine kinase activity
G6Z49_RS15425	COG1294	oxidase, subunit
G6Z49_RS15435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G6Z49_RS15440	COG0850	regulation of cytokinetic process
G6Z49_RS15445	COG2894	cell division
G6Z49_RS15450	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
G6Z49_RS15470	COG0488	(ABC) transporter
G6Z49_RS15475	COG0697	spore germination
G6Z49_RS15495	COG0463	Glycosyl transferase, family 2
G6Z49_RS15495	COG1216	Glycosyl transferase, family 2
G6Z49_RS15510	COG3949	Membrane
G6Z49_RS15520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G6Z49_RS15535	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS15545	COG0583	DNA-binding transcription factor activity
G6Z49_RS15550	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
G6Z49_RS15555	COG1538	Outer membrane efflux protein
G6Z49_RS15560	COG1136	(ABC) transporter
G6Z49_RS15560	COG0577	efflux transmembrane transporter activity
G6Z49_RS15565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G6Z49_RS15570	COG0583	DNA-binding transcription factor activity
G6Z49_RS15595	COG0259	pyridoxamine-phosphate oxidase activity
G6Z49_RS15600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G6Z49_RS15605	COG0579	oxidoreductase
G6Z49_RS15615	COG3210	domain, Protein
G6Z49_RS15625	COG0583	DNA-binding transcription factor activity
G6Z49_RS15630	COG1960	acyl-CoA dehydrogenase activity
G6Z49_RS15635	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS15640	COG0405	Gamma-glutamyltransferase
G6Z49_RS15650	COG0860	N-Acetylmuramoyl-L-alanine amidase
G6Z49_RS15655	COG0802	atpase or kinase
G6Z49_RS15660	COG0114	fumarate hydratase activity
G6Z49_RS15670	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS15675	COG3210	domain, Protein
G6Z49_RS15675	COG3210	domain, Protein
G6Z49_RS15675	COG3064	Membrane
G6Z49_RS15675	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
G6Z49_RS15675	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
G6Z49_RS15675	COG3064	Membrane
G6Z49_RS15680	COG0586	Pfam SNARE associated Golgi protein
G6Z49_RS15685	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G6Z49_RS15690	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G6Z49_RS15695	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
G6Z49_RS15710	COG0617	tRNA 3'-terminal CCA addition
G6Z49_RS15730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G6Z49_RS15735	COG2301	Belongs to the HpcH HpaI aldolase family
G6Z49_RS15745	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
G6Z49_RS15750	COG1024	Enoyl-CoA hydratase
G6Z49_RS15760	COG1960	acyl-CoA dehydrogenase activity
G6Z49_RS15770	COG0183	Belongs to the thiolase family
G6Z49_RS15775	COG0318	PFAM AMP-dependent synthetase and ligase
G6Z49_RS15785	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS15795	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS15800	COG2030	dehydratase
G6Z49_RS15815	COG1024	Enoyl-CoA hydratase
G6Z49_RS15820	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G6Z49_RS15850	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G6Z49_RS15855	COG0066	3-isopropylmalate dehydratase activity
G6Z49_RS15870	COG0752	glycyl-tRNA synthetase alpha subunit
G6Z49_RS15875	COG0751	glycine-tRNA ligase activity
G6Z49_RS15880	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
G6Z49_RS15885	COG0204	Acyl-transferase
G6Z49_RS15900	COG0242	peptide deformylase activity
G6Z49_RS15905	COG1960	acyl-CoA dehydrogenase activity
G6Z49_RS15910	COG0700	Nucleoside recognition
G6Z49_RS15915	COG0469	pyruvate kinase activity
G6Z49_RS15920	COG1929	Belongs to the glycerate kinase type-1 family
G6Z49_RS15930	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G6Z49_RS15935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G6Z49_RS15940	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
G6Z49_RS15950	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G6Z49_RS15960	COG0667	Aldo Keto reductase
G6Z49_RS15970	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G6Z49_RS15975	COG4106	trans-aconitate 2-methyltransferase activity
G6Z49_RS15990	COG1294	oxidase, subunit
G6Z49_RS15995	COG1271	oxidase subunit
G6Z49_RS16025	COG2982	Protein involved in outer membrane biogenesis
G6Z49_RS16030	COG2818	Glycosylase
G6Z49_RS16035	COG0727	PFAM Uncharacterised protein family (UPF0153)
G6Z49_RS16060	COG0604	alcohol dehydrogenase
G6Z49_RS16060	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS16060	COG3321	synthase
G6Z49_RS16065	COG0156	8-amino-7-oxononanoate synthase activity
G6Z49_RS16070	COG2877	3-deoxy-8-phosphooctulonate synthase activity
G6Z49_RS16085	COG2089	acid synthase
G6Z49_RS16100	COG1083	cytidylyl-transferase
G6Z49_RS16105	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G6Z49_RS16110	COG1086	Polysaccharide biosynthesis protein
G6Z49_RS16135	COG1596	polysaccharide export
G6Z49_RS16150	COG0300	oxidoreductase activity
G6Z49_RS16160	COG1464	Belongs to the NlpA lipoprotein family
G6Z49_RS16165	COG2011	ABC-type metal ion transport system permease component
G6Z49_RS16175	COG1501	Belongs to the glycosyl hydrolase 31 family
G6Z49_RS16180	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
G6Z49_RS16180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6Z49_RS16190	COG0318	PFAM AMP-dependent synthetase and ligase
G6Z49_RS16195	COG1473	amidohydrolase
G6Z49_RS16200	COG0583	DNA-binding transcription factor activity
G6Z49_RS16205	COG2855	membrane
G6Z49_RS16215	COG2239	Acts as a magnesium transporter
G6Z49_RS16230	COG1522	sequence-specific DNA binding
G6Z49_RS16250	COG0653	protein targeting
G6Z49_RS16255	COG0739	heme binding
G6Z49_RS16270	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
G6Z49_RS16275	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G6Z49_RS16285	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G6Z49_RS16290	COG1181	Belongs to the D-alanine--D-alanine ligase family
G6Z49_RS16295	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G6Z49_RS16300	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G6Z49_RS16310	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
G6Z49_RS16315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G6Z49_RS16320	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G6Z49_RS16330	COG3116	cell division
G6Z49_RS16335	COG0275	rRNA processing
G6Z49_RS16340	COG2001	Belongs to the MraZ family
G6Z49_RS16355	COG0418	dihydroorotase activity
G6Z49_RS16360	COG1473	amidohydrolase
G6Z49_RS16420	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G6Z49_RS16425	COG4654	Cytochrome c, class I
G6Z49_RS16430	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
G6Z49_RS16465	COG2084	Dehydrogenase
G6Z49_RS16470	COG0583	DNA-binding transcription factor activity
G6Z49_RS16500	COG0442	prolyl-tRNA aminoacylation
G6Z49_RS16505	COG0824	Thioesterase
G6Z49_RS16515	COG0848	biopolymer transport protein
G6Z49_RS16525	COG0823	Involved in the tonB-independent uptake of proteins
G6Z49_RS16545	COG2267	carboxylic ester hydrolase activity
G6Z49_RS16550	COG1522	sequence-specific DNA binding
G6Z49_RS16570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G6Z49_RS16595	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
G6Z49_RS16600	COG0463	Glycosyl transferase, family 2
G6Z49_RS16615	COG1671	Belongs to the UPF0178 family
G6Z49_RS16625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G6Z49_RS16630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G6Z49_RS16635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G6Z49_RS16640	COG0328	RNA-DNA hybrid ribonuclease activity
G6Z49_RS16645	COG2226	methyltransferase
G6Z49_RS16650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G6Z49_RS16655	COG0741	lytic transglycosylase activity
G6Z49_RS16655	COG1388	LysM domain
G6Z49_RS16665	COG2979	Protein of unknown function (DUF533)
G6Z49_RS16700	COG2816	NAD+ diphosphatase activity
G6Z49_RS16730	COG0583	DNA-binding transcription factor activity
G6Z49_RS16735	COG4948	Mandelate Racemase Muconate Lactonizing
G6Z49_RS16740	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G6Z49_RS16755	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G6Z49_RS16765	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G6Z49_RS16780	COG3246	L-lysine catabolic process to acetate
G6Z49_RS16785	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G6Z49_RS16790	COG0668	transmembrane transport
G6Z49_RS16795	COG1621	beta-fructofuranosidase activity
G6Z49_RS16810	COG0697	spore germination
G6Z49_RS16815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G6Z49_RS16820	COG2015	COG2015, Alkyl sulfatase and related hydrolases
G6Z49_RS16835	COG4977	sequence-specific DNA binding
G6Z49_RS16845	COG2072	flavoprotein involved in K transport
G6Z49_RS16855	COG1454	alcohol dehydrogenase
G6Z49_RS16865	COG0679	Auxin Efflux Carrier
G6Z49_RS16885	COG0028	Belongs to the TPP enzyme family
G6Z49_RS16900	COG0436	Aminotransferase
G6Z49_RS16905	COG0583	DNA-binding transcription factor activity
G6Z49_RS16915	COG0583	DNA-binding transcription factor activity
G6Z49_RS16940	COG1982	Orn Lys Arg decarboxylase major
G6Z49_RS16945	COG0531	amino acid
G6Z49_RS16965	COG3311	Transcriptional regulator
G6Z49_RS16975	COG2003	Belongs to the UPF0758 family
G6Z49_RS16980	COG5377	YqaJ viral recombinase family
G6Z49_RS16990	COG1002	Type II restriction enzyme, methylase subunits
G6Z49_RS16995	COG1061	Type III restriction enzyme res subunit
G6Z49_RS17010	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G6Z49_RS17015	COG0582	viral genome integration into host DNA
G6Z49_RS17035	COG0477	Major facilitator Superfamily
G6Z49_RS17050	COG2719	SpoVR family
G6Z49_RS17055	COG2718	Belongs to the UPF0229 family
G6Z49_RS17060	COG2766	serine protein kinase
G6Z49_RS17080	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G6Z49_RS17080	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G6Z49_RS17085	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G6Z49_RS17090	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G6Z49_RS17095	COG1881	PFAM PEBP family protein
G6Z49_RS17100	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G6Z49_RS17105	COG4942	peptidase
G6Z49_RS17110	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
G6Z49_RS17115	COG0316	Belongs to the HesB IscA family
G6Z49_RS17125	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
G6Z49_RS17130	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G6Z49_RS17135	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G6Z49_RS17140	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G6Z49_RS17155	COG0312	modulator of DNA gyrase
G6Z49_RS17160	COG3028	Belongs to the UPF0307 family
G6Z49_RS17170	COG0045	succinate-CoA ligase (ADP-forming) activity
G6Z49_RS17170	COG1042	CoA-binding domain protein
G6Z49_RS17170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G6Z49_RS17170	COG0045	succinate-CoA ligase (ADP-forming) activity
G6Z49_RS17170	COG1042	CoA-binding domain protein
G6Z49_RS17170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G6Z49_RS17175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G6Z49_RS17190	COG0583	DNA-binding transcription factor activity
G6Z49_RS17200	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS17250	COG2264	protein methyltransferase activity
G6Z49_RS17255	COG0439	Biotin carboxylase
G6Z49_RS17260	COG0511	ligase activity, forming carbon-carbon bonds
G6Z49_RS17265	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G6Z49_RS17270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G6Z49_RS17275	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G6Z49_RS17280	COG3150	esterase
G6Z49_RS17285	COG0557	exoribonuclease II activity
G6Z49_RS17295	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G6Z49_RS17300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G6Z49_RS17310	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G6Z49_RS17325	COG0540	Belongs to the ATCase OTCase family
G6Z49_RS17330	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G6Z49_RS17335	COG1678	Uncharacterized ACR, COG1678
G6Z49_RS17345	COG0351	phosphomethylpyrimidine kinase
G6Z49_RS17350	COG0352	thiamine-phosphate diphosphorylase activity
G6Z49_RS17355	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G6Z49_RS17380	COG1960	acyl-CoA dehydrogenase activity
G6Z49_RS17385	COG1024	Enoyl-CoA hydratase
G6Z49_RS17390	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS17400	COG3706	GGDEF domain
G6Z49_RS17460	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
G6Z49_RS17475	COG3539	Fimbrial protein
G6Z49_RS17485	COG3539	Fimbrial protein
G6Z49_RS17490	COG3539	Fimbrial protein
G6Z49_RS17495	COG3539	Fimbrial protein
G6Z49_RS17500	COG3539	Fimbrial protein
G6Z49_RS17505	COG3539	Fimbrial protein
G6Z49_RS17510	COG3539	Fimbrial protein
G6Z49_RS17515	COG3539	Fimbrial protein
G6Z49_RS17520	COG3539	Fimbrial protein
G6Z49_RS17525	COG3539	Fimbrial protein
G6Z49_RS17530	COG3539	Fimbrial protein
G6Z49_RS17535	COG3539	Fimbrial protein
G6Z49_RS17540	COG3539	Fimbrial protein
G6Z49_RS17550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G6Z49_RS17560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G6Z49_RS17565	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
G6Z49_RS17575	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
G6Z49_RS17585	COG4566	intracellular signal transduction
G6Z49_RS17590	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G6Z49_RS17595	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
G6Z49_RS17605	COG0477	Major facilitator Superfamily
G6Z49_RS17625	COG1126	abc transporter atp-binding protein
G6Z49_RS17630	COG0765	amino acid transport
G6Z49_RS17635	COG4597	amino acid ABC transporter
G6Z49_RS17640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6Z49_RS17645	COG2884	Cell division ATP-binding protein ftsE
G6Z49_RS17650	COG2177	Part of the ABC transporter FtsEX involved in
G6Z49_RS17655	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
G6Z49_RS17665	COG1194	a g-specific adenine glycosylase
G6Z49_RS17675	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS17685	COG1802	Transcriptional regulator
G6Z49_RS17695	COG2226	methyltransferase
G6Z49_RS17705	COG4206	TonB-dependent receptor
G6Z49_RS17710	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G6Z49_RS17715	COG2022	thiamine diphosphate biosynthetic process
G6Z49_RS17720	COG0351	phosphomethylpyrimidine kinase
G6Z49_RS17725	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G6Z49_RS17730	COG1538	Outer membrane efflux protein
G6Z49_RS17735	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
G6Z49_RS17745	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G6Z49_RS17760	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G6Z49_RS17790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G6Z49_RS17820	COG2226	methyltransferase
G6Z49_RS17825	COG0745	RESPONSE REGULATOR receiver
G6Z49_RS17830	COG5002	protein histidine kinase activity
G6Z49_RS17840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G6Z49_RS17855	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
G6Z49_RS17860	COG1984	allophanate hydrolase subunit 2
G6Z49_RS17870	COG1802	Transcriptional regulator
G6Z49_RS17880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G6Z49_RS17885	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G6Z49_RS17895	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G6Z49_RS17900	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
G6Z49_RS17905	COG4988	ABC transporter
G6Z49_RS17915	COG1294	oxidase, subunit
G6Z49_RS17930	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
G6Z49_RS17940	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
G6Z49_RS17955	COG1137	ATPase activity
G6Z49_RS17960	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
G6Z49_RS17970	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
G6Z49_RS17975	COG1660	Displays ATPase and GTPase activities
G6Z49_RS17995	COG0792	nuclease activity
G6Z49_RS18000	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
G6Z49_RS18005	COG2823	Periplasmic or secreted lipoprotein
G6Z49_RS18020	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G6Z49_RS18030	COG1309	transcriptional regulator
G6Z49_RS18035	COG0471	metal ion transport
G6Z49_RS18040	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
G6Z49_RS18045	COG0772	Belongs to the SEDS family
G6Z49_RS18060	COG1792	Involved in formation and maintenance of cell shape
G6Z49_RS18065	COG1077	Cell shape determining protein MreB Mrl
G6Z49_RS18070	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G6Z49_RS18075	COG0154	amidase activity
G6Z49_RS18080	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G6Z49_RS18085	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G6Z49_RS18095	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G6Z49_RS18100	COG2860	membrane
G6Z49_RS18110	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G6Z49_RS18115	COG2223	nitrite transmembrane transporter activity
G6Z49_RS18120	COG2813	Specifically methylates the guanine in position
G6Z49_RS18120	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G6Z49_RS18125	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G6Z49_RS18140	COG2918	glutathione biosynthetic process
G6Z49_RS18145	COG3040	lipid binding
G6Z49_RS18165	COG1250	3-hydroxyacyl-CoA dehydrogenase
G6Z49_RS18175	COG1960	acyl-CoA dehydrogenase activity
G6Z49_RS18190	COG1024	Enoyl-CoA hydratase
G6Z49_RS18195	COG1024	Enoyl-CoA hydratase
G6Z49_RS18200	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G6Z49_RS18210	COG0747	negative chemotaxis
G6Z49_RS18220	COG0601	transmembrane transport
G6Z49_RS18225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6Z49_RS18230	COG0444	Belongs to the ABC transporter superfamily
G6Z49_RS18235	COG4608	Belongs to the ABC transporter superfamily
G6Z49_RS18250	COG0210	DNA helicase
G6Z49_RS18255	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G6Z49_RS18260	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
G6Z49_RS18270	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G6Z49_RS18280	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G6Z49_RS18285	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G6Z49_RS18290	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G6Z49_RS18295	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G6Z49_RS18305	COG0356	it plays a direct role in the translocation of protons across the membrane
G6Z49_RS18315	COG1024	Enoyl-CoA hydratase
G6Z49_RS18335	COG0037	tRNA processing
G6Z49_RS18340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G6Z49_RS18345	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G6Z49_RS18350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G6Z49_RS18355	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
G6Z49_RS18360	COG2967	ApaG domain
G6Z49_RS18365	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G6Z49_RS18370	COG0546	phosphoglycolate phosphatase activity
G6Z49_RS18380	COG0512	Glutamine amidotransferase of anthranilate synthase
G6Z49_RS18385	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G6Z49_RS18390	COG0134	indole-3-glycerol-phosphate synthase activity
G6Z49_RS18425	COG3276	selenocysteine insertion sequence binding
G6Z49_RS18440	COG2864	formate dehydrogenase
G6Z49_RS18445	COG0437	4 iron, 4 sulfur cluster binding
G6Z49_RS18460	COG1607	acyl-coa hydrolase
G6Z49_RS18485	COG3712	iron ion homeostasis
G6Z49_RS18490	COG4771	TonB-dependent receptor
G6Z49_RS18490	COG1629	transport
G6Z49_RS18495	COG3720	iron ion transport
G6Z49_RS18500	COG4558	Periplasmic binding protein
G6Z49_RS18505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G6Z49_RS18510	COG1120	ATPase activity
G6Z49_RS18520	COG1683	Conserved Protein
G6Z49_RS18540	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G6Z49_RS18540	COG2169	Transcriptional regulator
G6Z49_RS18555	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G6Z49_RS18560	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G6Z49_RS18560	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G6Z49_RS18560	COG0506	proline dehydrogenase activity
G6Z49_RS18570	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G6Z49_RS18575	COG0477	Major facilitator Superfamily
G6Z49_RS18580	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G6Z49_RS18585	COG1278	Cold shock
G6Z49_RS18590	COG5383	Protein conserved in bacteria
G6Z49_RS18610	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS18615	COG0251	oxidation-reduction process
G6Z49_RS18635	COG0443	Heat shock 70 kDa protein
G6Z49_RS18640	COG0583	DNA-binding transcription factor activity
G6Z49_RS18645	COG2271	Major facilitator Superfamily
G6Z49_RS18715	COG1522	sequence-specific DNA binding
G6Z49_RS18730	COG2814	Major facilitator Superfamily
G6Z49_RS18735	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G6Z49_RS18750	COG1999	signal sequence binding
G6Z49_RS18755	COG0109	protoheme IX farnesyltransferase activity
G6Z49_RS18760	COG1612	heme a metabolic process
G6Z49_RS18780	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G6Z49_RS18785	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G6Z49_RS18800	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
G6Z49_RS18815	COG0067	glutamate synthase
G6Z49_RS18815	COG0069	glutamate synthase activity
G6Z49_RS18815	COG0070	glutamate synthase
G6Z49_RS18845	COG3021	interspecies interaction between organisms
G6Z49_RS18870	COG1984	allophanate hydrolase subunit 2
G6Z49_RS18880	COG0439	Biotin carboxylase
G6Z49_RS18885	COG0511	ligase activity, forming carbon-carbon bonds
G6Z49_RS18890	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
G6Z49_RS18910	COG1127	ABC transporter
G6Z49_RS18915	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G6Z49_RS18920	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G6Z49_RS18935	COG1131	(ABC) transporter
G6Z49_RS18940	COG0842	Transport permease protein
G6Z49_RS18950	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G6Z49_RS18955	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G6Z49_RS18960	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G6Z49_RS18965	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G6Z49_RS18970	COG0131	Imidazoleglycerol-phosphate dehydratase
G6Z49_RS18980	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
G6Z49_RS18985	COG0107	imidazoleglycerol-phosphate synthase activity
G6Z49_RS18990	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G6Z49_RS18995	COG0140	phosphoribosyl-ATP diphosphatase activity
G6Z49_RS19000	COG0537	adenosine 5'-monophosphoramidase activity
G6Z49_RS19005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G6Z49_RS19010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G6Z49_RS19020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G6Z49_RS19025	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
G6Z49_RS19030	COG1970	mechanosensitive ion channel activity
G6Z49_RS19035	COG0723	plastoquinol--plastocyanin reductase activity
G6Z49_RS19040	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G6Z49_RS19045	COG2857	Cytochrome c1
G6Z49_RS19050	COG0625	glutathione transferase activity
G6Z49_RS19055	COG2969	positive regulation of protein catabolic process
G6Z49_RS19085	COG0697	spore germination
G6Z49_RS19100	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G6Z49_RS19115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6Z49_RS19120	COG4172	Belongs to the ABC transporter superfamily
G6Z49_RS19125	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
G6Z49_RS19135	COG0513	Belongs to the DEAD box helicase family
G6Z49_RS19140	COG1280	lysine exporter protein (LysE YggA)
G6Z49_RS19145	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
G6Z49_RS19165	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
G6Z49_RS19175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G6Z49_RS19180	COG0154	amidase activity
G6Z49_RS19185	COG1609	Transcriptional regulator
G6Z49_RS19205	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G6Z49_RS19210	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G6Z49_RS19215	COG3842	ATPase activity
G6Z49_RS19225	COG1175	transmembrane transport
G6Z49_RS19230	COG0395	ABC-type sugar transport system, permease component
G6Z49_RS19245	COG0018	arginyl-trna synthetase
G6Z49_RS19255	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G6Z49_RS19265	COG1280	lysine exporter protein (LysE YggA)
G6Z49_RS19285	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS19290	COG0583	DNA-binding transcription factor activity
G6Z49_RS19305	COG3181	Tripartite tricarboxylate transporter family receptor
G6Z49_RS19310	COG1473	amidohydrolase
G6Z49_RS19315	COG1960	acyl-CoA dehydrogenase activity
G6Z49_RS19320	COG0183	Belongs to the thiolase family
G6Z49_RS19325	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G6Z49_RS19340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G6Z49_RS19350	COG2358	TRAP transporter, solute receptor (TAXI family
G6Z49_RS19360	COG2922	Belongs to the Smg family
G6Z49_RS19365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G6Z49_RS19375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G6Z49_RS19375	COG0551	DNA topoisomerase type I activity
G6Z49_RS19385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6Z49_RS19390	COG0765	amino acid transport
G6Z49_RS19400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6Z49_RS19405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6Z49_RS19410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G6Z49_RS19415	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
G6Z49_RS19420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6Z49_RS19425	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z49_RS19430	COG1012	belongs to the aldehyde dehydrogenase family
G6Z49_RS19440	COG0028	Belongs to the TPP enzyme family
G6Z49_RS19445	COG1522	sequence-specific DNA binding
G6Z49_RS19450	COG3781	membrane
G6Z49_RS19480	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
G6Z49_RS19490	COG1304	FMN binding
G6Z49_RS19495	COG1254	Belongs to the acylphosphatase family
G6Z49_RS19505	COG0154	amidase activity
G6Z49_RS19510	COG1414	Transcriptional regulator
G6Z49_RS19515	COG2814	Major facilitator Superfamily
G6Z49_RS19520	COG0697	spore germination
G6Z49_RS19535	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G6Z49_RS19540	COG0230	Belongs to the bacterial ribosomal protein bL34 family
G6Z49_RS19545	COG0594	ribonuclease P activity
G6Z49_RS19550	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G6Z49_RS19555	COG0706	membrane insertase activity
G6Z49_RS19560	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
G6Z49_RS19570	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
G6Z49_RS19580	COG2175	clavaminate synthase activity
G6Z49_RS19585	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
G6Z49_RS19590	COG0582	viral genome integration into host DNA
G6Z49_RS19620	COG3645	SOS response
G6Z49_RS19650	COG3093	addiction module antidote protein HigA
G6Z49_RS19665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G6Z49_RS19680	COG1505	serine-type exopeptidase activity
G6Z49_RS19690	COG0280	phosphate acetyltransferase
G6Z49_RS19690	COG0281	malic enzyme
G6Z49_RS19725	COG0436	Aminotransferase
G6Z49_RS19730	COG3180	Ammonia monooxygenase
G6Z49_RS19735	COG1278	Cold shock
G6Z49_RS19740	COG0445	tRNA wobble uridine modification
G6Z49_RS19745	COG0357	Ribosomal RNA small subunit methyltransferase G
G6Z49_RS19750	COG1192	Involved in chromosome partitioning
G6Z49_RS19755	COG1475	DNA binding
G6Z49_RS19760	COG0252	asparaginase activity
G6Z49_RS19780	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G6Z49_RS19790	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G6Z49_RS19805	COG0081	regulation of translation
G6Z49_RS19810	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G6Z49_RS19815	COG0222	ribosome binding
G6Z49_RS19820	COG0085	RNA polymerase activity
G6Z49_RS19825	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G6Z49_RS19860	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G6Z49_RS19865	COG0049	tRNA binding
G6Z49_RS19870	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G6Z49_RS19875	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G6Z49_RS19880	COG0051	transcription antitermination factor activity, RNA binding
G6Z49_RS19885	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G6Z49_RS19890	COG0088	Forms part of the polypeptide exit tunnel
G6Z49_RS19895	COG0089	rRNA binding
G6Z49_RS19900	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G6Z49_RS19905	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
G6Z49_RS19910	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G6Z49_RS19915	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
G6Z49_RS19920	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
G6Z49_RS19925	COG0255	Belongs to the universal ribosomal protein uL29 family
G6Z49_RS19930	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
G6Z49_RS19950	COG0411	ABC transporter
G6Z49_RS19960	COG2267	carboxylic ester hydrolase activity
G6Z49_RS19980	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
G6Z49_RS19985	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G6Z49_RS19990	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G6Z49_RS19995	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G6Z49_RS20000	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G6Z49_RS20010	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G6Z49_RS20015	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G6Z49_RS20020	COG1841	ribosomal large subunit assembly
G6Z49_RS20025	COG0200	Binds to the 23S rRNA
G6Z49_RS20030	COG0201	protein transport
G6Z49_RS20035	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G6Z49_RS20040	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G6Z49_RS20045	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G6Z49_RS20050	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
G6Z49_RS20055	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G6Z49_RS20060	COG0202	RNA polymerase activity
G6Z49_RS20065	COG0203	ribosomal protein L17
G6Z49_RS20075	COG1324	tolerance protein
G6Z49_RS20080	COG4232	protein-disulfide reductase activity
G6Z49_RS20090	COG0218	Necessary for normal cell division and for the maintenance of normal septation
G6Z49_RS20100	COG1333	cytochrome c biogenesis protein
G6Z49_RS20105	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G6Z49_RS20115	COG1965	Belongs to the frataxin family
G6Z49_RS20125	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G6Z49_RS20130	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
G6Z49_RS20135	COG0232	Belongs to the dGTPase family. Type 2 subfamily
G6Z49_RS20150	COG2814	Major facilitator Superfamily
G6Z49_RS20215	COG2814	Major facilitator Superfamily
G6Z49_RS20220	COG0583	DNA-binding transcription factor activity
G6Z49_RS20235	COG0183	Belongs to the thiolase family
G6Z49_RS20240	COG1960	acyl-CoA dehydrogenase activity
G6Z49_RS20245	COG1024	Enoyl-CoA hydratase
G6Z49_RS20260	COG0745	RESPONSE REGULATOR receiver
G6Z49_RS20270	COG2197	response regulator
G6Z49_RS20275	COG3850	Histidine kinase
G6Z49_RS20280	COG1763	Mo-molybdopterin cofactor biosynthetic process
G6Z49_RS20285	COG2181	nitrate reductase activity
G6Z49_RS20290	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
G6Z49_RS20295	COG1140	nitrate reductase beta subunit
G6Z49_RS20300	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
G6Z49_RS20305	COG2223	nitrite transmembrane transporter activity
G6Z49_RS20335	COG0037	tRNA processing
G6Z49_RS20345	COG0482	sulfurtransferase activity
G6Z49_RS20390	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
G6Z49_RS20400	COG2186	Transcriptional regulator
G6Z49_RS20415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G6Z49_RS20420	COG1956	GAF domain-containing protein
G6Z49_RS20425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G6Z49_RS20450	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)