locus-tag	class	description
A7X70_RS00015	COG1472	Belongs to the glycosyl hydrolase 3 family
A7X70_RS00025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A7X70_RS00090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A7X70_RS00110	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A7X70_RS00160	COG0681	Belongs to the peptidase S26 family
A7X70_RS00170	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A7X70_RS00225	COG1196	nuclear chromosome segregation
A7X70_RS00250	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A7X70_RS00300	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A7X70_RS00340	COG0561	phosphatase activity
A7X70_RS00345	COG2309	aminopeptidase activity
A7X70_RS00350	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
A7X70_RS00380	COG0552	protein localization to endoplasmic reticulum
A7X70_RS00390	COG4591	ABC-type transport system involved in lipoprotein release permease component
A7X70_RS00395	COG1136	(ABC) transporter
A7X70_RS00515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A7X70_RS00530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A7X70_RS00550	COG0305	Participates in initiation and elongation during chromosome replication
A7X70_RS00555	COG0359	binds to the 23S rRNA
A7X70_RS00575	COG2190	(PTS) system
A7X70_RS00575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7X70_RS00575	COG1263	PTS System
A7X70_RS00590	COG4589	Belongs to the CDS family
A7X70_RS00630	COG0539	negative regulation of cytoplasmic translation
A7X70_RS00675	COG0768	penicillin binding
A7X70_RS00680	COG1022	Amp-dependent synthetase and ligase
A7X70_RS00720	COG4176	ABC-type proline glycine betaine transport system permease component
A7X70_RS00725	COG4175	Glycine betaine
A7X70_RS00725	COG3448	diguanylate cyclase activity
A7X70_RS00740	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A7X70_RS00745	COG0363	glucosamine-6-phosphate deaminase activity
A7X70_RS00810	COG1640	4-alpha-glucanotransferase
A7X70_RS00860	COG0714	Associated with various cellular activities
A7X70_RS00865	COG0357	Ribosomal RNA small subunit methyltransferase G
A7X70_RS00890	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A7X70_RS00900	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A7X70_RS00905	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A7X70_RS00920	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A7X70_RS00945	COG0084	hydrolase, TatD family'
A7X70_RS00990	COG1253	flavin adenine dinucleotide binding
A7X70_RS01020	COG0742	ribosomal rna small subunit methyltransferase
A7X70_RS01045	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A7X70_RS01075	COG0573	inorganic phosphate transmembrane transporter activity
A7X70_RS01080	COG0581	inorganic phosphate transmembrane transporter activity
A7X70_RS01085	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A7X70_RS01095	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A7X70_RS01100	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A7X70_RS01120	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A7X70_RS01140	COG0254	rRNA binding
A7X70_RS01170	COG0012	GTP binding
A7X70_RS01190	COG1428	Deoxynucleoside kinase
A7X70_RS01195	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A7X70_RS01205	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A7X70_RS01220	COG0739	heme binding
A7X70_RS01265	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A7X70_RS01270	COG0739	heme binding
A7X70_RS01310	COG0681	Belongs to the peptidase S26 family
A7X70_RS01315	COG0443	Heat shock 70 kDa protein
A7X70_RS01395	COG1360	Flagellar Motor Protein
A7X70_RS01405	COG1582	Flagellar protein (FlbD)
A7X70_RS01415	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A7X70_RS01475	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A7X70_RS01500	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A7X70_RS01550	COG0835	chemotaxis
A7X70_RS01635	COG4166	transmembrane transport
A7X70_RS01645	COG0601	transmembrane transport
A7X70_RS01650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7X70_RS01655	COG0444	Belongs to the ABC transporter superfamily
A7X70_RS01660	COG4608	Belongs to the ABC transporter superfamily
A7X70_RS01675	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A7X70_RS01680	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A7X70_RS01695	COG0154	amidase activity
A7X70_RS01705	COG0210	DNA helicase
A7X70_RS01775	COG0793	Belongs to the peptidase S41A family
A7X70_RS01785	COG0455	bacterial-type flagellum organization
A7X70_RS01820	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A7X70_RS01825	COG0542	response to heat
A7X70_RS01855	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A7X70_RS01880	COG2239	Acts as a magnesium transporter
A7X70_RS01890	COG1744	ABC transporter substrate-binding protein PnrA-like
A7X70_RS01895	COG1744	ABC transporter substrate-binding protein PnrA-like
A7X70_RS01910	COG0049	tRNA binding
A7X70_RS01925	COG0085	RNA polymerase activity
A7X70_RS02025	COG1482	cell wall glycoprotein biosynthetic process
A7X70_RS02030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7X70_RS02030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7X70_RS02030	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7X70_RS02085	COG4999	Histidine kinase
A7X70_RS02085	COG2205	protein histidine kinase activity
A7X70_RS02085	COG3850	Histidine kinase
A7X70_RS02085	COG3437	response regulator, receiver
A7X70_RS02110	COG0561	phosphatase activity
A7X70_RS02140	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A7X70_RS02155	COG1739	Uncharacterized protein family UPF0029
A7X70_RS02160	COG1192	Involved in chromosome partitioning
A7X70_RS02200	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A7X70_RS02250	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A7X70_RS02265	COG0668	transmembrane transport
A7X70_RS02330	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A7X70_RS02355	COG1137	ATPase activity
A7X70_RS02500	COG1841	ribosomal large subunit assembly
A7X70_RS02515	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A7X70_RS02535	COG0203	ribosomal protein L17
A7X70_RS02545	COG1692	metallophosphoesterase
A7X70_RS02550	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A7X70_RS02605	COG0443	Heat shock 70 kDa protein
A7X70_RS02610	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A7X70_RS02615	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A7X70_RS02615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7X70_RS02640	COG0667	Aldo Keto reductase
A7X70_RS02660	COG0321	lipoyl(octanoyl) transferase activity
A7X70_RS02660	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A7X70_RS02665	COG0708	Exodeoxyribonuclease III
A7X70_RS02675	COG0612	Peptidase, M16
A7X70_RS02760	COG2201	protein-glutamate methylesterase activity
A7X70_RS02810	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A7X70_RS02830	COG0835	chemotaxis
A7X70_RS02840	COG0643	Histidine kinase
A7X70_RS02840	COG2198	Histidine kinase
A7X70_RS02855	COG0745	RESPONSE REGULATOR receiver
A7X70_RS02865	COG0528	UMP kinase activity
A7X70_RS02870	COG1216	Glycosyl transferase, family 2
A7X70_RS02875	COG1121	(ABC) transporter
A7X70_RS02900	COG3290	protein histidine kinase activity
A7X70_RS02900	COG0840	transmembrane signaling receptor activity
A7X70_RS02935	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A7X70_RS02940	COG2348	transferase activity, transferring amino-acyl groups
A7X70_RS02950	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A7X70_RS02975	COG1022	Amp-dependent synthetase and ligase
A7X70_RS02980	COG0018	arginyl-trna synthetase
A7X70_RS02990	COG0840	transmembrane signaling receptor activity
A7X70_RS02995	COG5278	phosphoserine phosphatase activity
A7X70_RS02995	COG0840	transmembrane signaling receptor activity
A7X70_RS03030	COG1620	l-lactate permease
A7X70_RS03035	COG1686	Belongs to the peptidase S11 family
A7X70_RS03045	COG0210	DNA helicase
A7X70_RS03050	COG2195	Cleaves the N-terminal amino acid of tripeptides
A7X70_RS03075	COG0544	peptidyl-prolyl cis-trans isomerase activity
A7X70_RS03080	COG0740	serine-type endopeptidase activity
A7X70_RS03115	COG0295	cytidine deaminase activity
A7X70_RS03155	COG0860	N-Acetylmuramoyl-L-alanine amidase
A7X70_RS03180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7X70_RS03180	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7X70_RS03180	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7X70_RS03200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A7X70_RS03215	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A7X70_RS03230	COG1757	Na H antiporter
A7X70_RS03240	COG1177	transmembrane transport
A7X70_RS03245	COG1176	ABC-type spermidine putrescine transport system, permease component I
A7X70_RS03255	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A7X70_RS03285	COG0459	protein refolding
A7X70_RS03315	COG0484	heat shock protein binding
A7X70_RS03320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A7X70_RS03370	COG0860	N-Acetylmuramoyl-L-alanine amidase
A7X70_RS03370	COG1388	LysM domain
A7X70_RS03390	COG0835	chemotaxis
A7X70_RS03400	COG2201	protein-glutamate methylesterase activity
A7X70_RS03425	COG3845	ABC transporter
A7X70_RS03430	COG4603	Belongs to the binding-protein-dependent transport system permease family
A7X70_RS03435	COG1079	Belongs to the binding-protein-dependent transport system permease family
A7X70_RS03445	COG0840	transmembrane signaling receptor activity
A7X70_RS03455	COG3425	synthase
A7X70_RS03495	COG0783	Belongs to the Dps family
A7X70_RS03510	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A7X70_RS03515	COG0228	four-way junction DNA binding
A7X70_RS03525	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A7X70_RS03530	COG0336	Belongs to the RNA methyltransferase TrmD family
A7X70_RS03555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7X70_RS03565	COG0617	tRNA 3'-terminal CCA addition
A7X70_RS03590	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A7X70_RS03620	COG1077	Cell shape determining protein MreB Mrl
A7X70_RS03635	COG0768	penicillin binding
A7X70_RS03640	COG0772	Belongs to the SEDS family
A7X70_RS03650	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A7X70_RS03665	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A7X70_RS03675	COG0003	Pfam Anion-transporting ATPase
A7X70_RS03685	COG0446	pyridine nucleotide-disulphide oxidoreductase
A7X70_RS03700	COG1475	DNA binding
A7X70_RS03715	COG0009	L-threonylcarbamoyladenylate synthase
A7X70_RS03720	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A7X70_RS03740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7X70_RS03740	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A7X70_RS03750	COG0488	(ABC) transporter
A7X70_RS03775	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A7X70_RS03780	COG4239	(ABC) transporter, permease
A7X70_RS03785	COG4168	peptide transport system, permease
A7X70_RS03815	COG1131	(ABC) transporter
A7X70_RS03820	COG1234	tRNA 3'-trailer cleavage
A7X70_RS03825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7X70_RS03855	COG0739	heme binding
A7X70_RS03860	COG2204	response regulator
A7X70_RS03865	COG5002	protein histidine kinase activity
A7X70_RS03870	COG0470	DNA polymerase III
A7X70_RS03900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A7X70_RS03925	COG4786	Flagellar basal body rod
A7X70_RS03990	COG0193	aminoacyl-tRNA hydrolase activity
A7X70_RS03995	COG0037	tRNA processing
A7X70_RS04020	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A7X70_RS04030	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A7X70_RS04100	COG0343	queuine tRNA-ribosyltransferase activity
A7X70_RS04125	COG4145	pantothenate transmembrane transporter activity
A7X70_RS04130	COG0564	pseudouridine synthase activity
A7X70_RS04145	COG1561	YicC-like family, N-terminal region
A7X70_RS04200	COG0419	ATPase involved in DNA repair
A7X70_RS04205	COG1940	carbohydrate kinase activity
A7X70_RS04225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A7X70_RS04270	COG1288	antiporter activity
A7X70_RS04305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A7X70_RS04375	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A7X70_RS04540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A7X70_RS05400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284