locus-tag	class	description
CNO12_RS00005	COG0549	Belongs to the carbamate kinase family
CNO12_RS00010	COG1288	antiporter activity
CNO12_RS00020	COG2235	arginine
CNO12_RS00045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CNO12_RS00065	COG3142	Participates in the control of copper homeostasis
CNO12_RS00095	COG2190	(PTS) system
CNO12_RS00095	COG1263	PTS System
CNO12_RS00095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CNO12_RS00130	COG1102	Psort location Cytoplasmic, score
CNO12_RS00140	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CNO12_RS00155	COG4145	pantothenate transmembrane transporter activity
CNO12_RS00220	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CNO12_RS00220	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CNO12_RS00250	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CNO12_RS00260	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CNO12_RS00275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CNO12_RS00295	COG0037	tRNA processing
CNO12_RS00300	COG0193	aminoacyl-tRNA hydrolase activity
CNO12_RS00315	COG2088	sporulation resulting in formation of a cellular spore
CNO12_RS00335	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CNO12_RS00355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CNO12_RS00365	COG4786	Flagellar basal body rod
CNO12_RS00385	COG3951	Flagellar rod assembly protein muramidase FlgJ
CNO12_RS00390	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CNO12_RS00410	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CNO12_RS00420	COG0470	DNA polymerase III
CNO12_RS00425	COG5002	protein histidine kinase activity
CNO12_RS00430	COG2204	response regulator
CNO12_RS00435	COG0739	heme binding
CNO12_RS00475	COG1131	(ABC) transporter
CNO12_RS00505	COG0601	transmembrane transport
CNO12_RS00510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CNO12_RS00515	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CNO12_RS00540	COG0488	(ABC) transporter
CNO12_RS00545	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CNO12_RS00550	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CNO12_RS00550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CNO12_RS00555	COG0525	valine-tRNA ligase activity
CNO12_RS00560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CNO12_RS00570	COG1199	ATP-dependent helicase activity
CNO12_RS00575	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CNO12_RS00580	COG0009	L-threonylcarbamoyladenylate synthase
CNO12_RS00600	COG1475	DNA binding
CNO12_RS00605	COG0166	Belongs to the GPI family
CNO12_RS00615	COG0446	pyridine nucleotide-disulphide oxidoreductase
CNO12_RS00625	COG0489	protein tyrosine kinase activity
CNO12_RS00635	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CNO12_RS00650	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CNO12_RS00660	COG0772	Belongs to the SEDS family
CNO12_RS00665	COG0768	penicillin binding
CNO12_RS00710	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CNO12_RS00735	COG0617	tRNA 3'-terminal CCA addition
CNO12_RS00745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CNO12_RS00750	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CNO12_RS00755	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CNO12_RS00765	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CNO12_RS00775	COG0335	large ribosomal subunit rRNA binding
CNO12_RS00785	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CNO12_RS00800	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CNO12_RS00810	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CNO12_RS00815	COG0783	Belongs to the Dps family
CNO12_RS00850	COG1304	FMN binding
CNO12_RS00855	COG3425	synthase
CNO12_RS00860	COG0482	sulfurtransferase activity
CNO12_RS00865	COG0840	transmembrane signaling receptor activity
CNO12_RS00875	COG1079	Belongs to the binding-protein-dependent transport system permease family
CNO12_RS00880	COG4603	Belongs to the binding-protein-dependent transport system permease family
CNO12_RS00885	COG3845	ABC transporter
CNO12_RS00890	COG0546	phosphoglycolate phosphatase activity
CNO12_RS00910	COG2201	protein-glutamate methylesterase activity
CNO12_RS00920	COG0835	chemotaxis
CNO12_RS00940	COG0860	N-Acetylmuramoyl-L-alanine amidase
CNO12_RS00980	COG0588	phosphoglycerate mutase activity
CNO12_RS00995	COG0484	heat shock protein binding
CNO12_RS01025	COG0459	protein refolding
CNO12_RS01045	COG2190	(PTS) system
CNO12_RS01045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CNO12_RS01045	COG1263	PTS System
CNO12_RS01050	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CNO12_RS01055	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CNO12_RS01070	COG1177	transmembrane transport
CNO12_RS01080	COG1757	Na H antiporter
CNO12_RS01095	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CNO12_RS01100	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CNO12_RS01110	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CNO12_RS01125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CNO12_RS01125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CNO12_RS01125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CNO12_RS01150	COG3584	3D domain protein
CNO12_RS01150	COG1388	LysM domain
CNO12_RS01170	COG0693	protein deglycase activity
CNO12_RS01220	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CNO12_RS01225	COG0740	serine-type endopeptidase activity
CNO12_RS01230	COG0544	peptidyl-prolyl cis-trans isomerase activity
CNO12_RS01255	COG2195	Cleaves the N-terminal amino acid of tripeptides
CNO12_RS01260	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CNO12_RS01265	COG1686	Belongs to the peptidase S11 family
CNO12_RS01270	COG1620	l-lactate permease
CNO12_RS01285	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CNO12_RS01295	COG0215	cysteine-tRNA ligase activity
CNO12_RS01305	COG5278	phosphoserine phosphatase activity
CNO12_RS01305	COG0840	transmembrane signaling receptor activity
CNO12_RS01310	COG0840	transmembrane signaling receptor activity
CNO12_RS01325	COG1022	Amp-dependent synthetase and ligase
CNO12_RS01335	COG0658	competence protein
CNO12_RS01340	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CNO12_RS01350	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CNO12_RS01350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CNO12_RS01360	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CNO12_RS01365	COG0534	Mate efflux family protein
CNO12_RS01390	COG0504	CTP synthase activity
CNO12_RS01420	COG0745	RESPONSE REGULATOR receiver
CNO12_RS01435	COG0643	Histidine kinase
CNO12_RS01435	COG2198	Histidine kinase
CNO12_RS01445	COG0835	chemotaxis
CNO12_RS01460	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CNO12_RS01465	COG0326	Molecular chaperone. Has ATPase activity
CNO12_RS01510	COG2201	protein-glutamate methylesterase activity
CNO12_RS01540	COG1070	Carbohydrate kinase
CNO12_RS01605	COG0612	Peptidase, M16
CNO12_RS01615	COG0708	Exodeoxyribonuclease III
CNO12_RS01620	COG0321	lipoyl(octanoyl) transferase activity
CNO12_RS01620	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CNO12_RS01655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CNO12_RS01655	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CNO12_RS01660	COG0386	Belongs to the glutathione peroxidase family
CNO12_RS01715	COG1160	GTP binding
CNO12_RS01730	COG1692	metallophosphoesterase
CNO12_RS01740	COG0203	ribosomal protein L17
CNO12_RS01745	COG0202	RNA polymerase activity
CNO12_RS01755	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CNO12_RS01760	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CNO12_RS01785	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CNO12_RS01790	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CNO12_RS01795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CNO12_RS01800	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CNO12_RS01805	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CNO12_RS01810	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CNO12_RS01820	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CNO12_RS01825	COG0255	Belongs to the universal ribosomal protein uL29 family
CNO12_RS01830	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CNO12_RS01835	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CNO12_RS01850	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CNO12_RS01860	COG0088	Forms part of the polypeptide exit tunnel
CNO12_RS01865	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CNO12_RS01870	COG0051	transcription antitermination factor activity, RNA binding
CNO12_RS01875	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CNO12_RS01885	COG0534	Mate efflux family protein
CNO12_RS01905	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CNO12_RS01920	COG1137	ATPase activity
CNO12_RS01945	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CNO12_RS01950	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CNO12_RS01955	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CNO12_RS02000	COG0322	excinuclease ABC activity
CNO12_RS02010	COG0438	transferase activity, transferring glycosyl groups
CNO12_RS02015	COG0668	transmembrane transport
CNO12_RS02025	COG2059	Chromate
CNO12_RS02030	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CNO12_RS02080	COG0594	ribonuclease P activity
CNO12_RS02085	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CNO12_RS02095	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CNO12_RS02110	COG0187	DNA topoisomerase II activity
CNO12_RS02130	COG1192	Involved in chromosome partitioning
CNO12_RS02150	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CNO12_RS02160	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CNO12_RS02185	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CNO12_RS02190	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CNO12_RS02200	COG0561	phosphatase activity
CNO12_RS02230	COG0563	adenylate kinase activity
CNO12_RS02325	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CNO12_RS02345	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CNO12_RS02350	COG0081	regulation of translation
CNO12_RS02360	COG0222	ribosome binding
CNO12_RS02365	COG0085	RNA polymerase activity
CNO12_RS02370	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CNO12_RS02375	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CNO12_RS02380	COG0049	tRNA binding
CNO12_RS02395	COG1744	ABC transporter substrate-binding protein PnrA-like
CNO12_RS02405	COG2239	Acts as a magnesium transporter
CNO12_RS02415	COG1854	S-ribosylhomocysteine lyase activity
CNO12_RS02420	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CNO12_RS02425	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CNO12_RS02455	COG0542	response to heat
CNO12_RS02460	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CNO12_RS02470	COG1362	aminopeptidase activity
CNO12_RS02480	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CNO12_RS02485	COG0455	bacterial-type flagellum organization
CNO12_RS02495	COG0793	Belongs to the peptidase S41A family
CNO12_RS02535	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CNO12_RS02565	COG0210	DNA helicase
CNO12_RS02575	COG0154	amidase activity
CNO12_RS02580	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CNO12_RS02600	COG0148	phosphopyruvate hydratase activity
CNO12_RS02610	COG4608	Belongs to the ABC transporter superfamily
CNO12_RS02615	COG0444	Belongs to the ABC transporter superfamily
CNO12_RS02620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CNO12_RS02625	COG0601	transmembrane transport
CNO12_RS02695	COG0142	geranyltranstransferase activity
CNO12_RS02700	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CNO12_RS02705	COG0835	chemotaxis
CNO12_RS02710	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CNO12_RS02785	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CNO12_RS02795	COG1815	bacterial-type flagellum-dependent cell motility
CNO12_RS02845	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CNO12_RS02865	COG1360	Flagellar Motor Protein
CNO12_RS02945	COG0443	Heat shock 70 kDa protein
CNO12_RS02955	COG1196	nuclear chromosome segregation
CNO12_RS02955	COG0741	lytic transglycosylase activity
CNO12_RS02955	COG0739	heme binding
CNO12_RS02990	COG0739	heme binding
CNO12_RS02995	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CNO12_RS03005	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CNO12_RS03015	COG0495	leucyl-tRNA aminoacylation
CNO12_RS03040	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CNO12_RS03045	COG0739	heme binding
CNO12_RS03065	COG0584	glycerophosphoryl diester phosphodiesterase
CNO12_RS03070	COG2271	Major facilitator Superfamily
CNO12_RS03080	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CNO12_RS03090	COG1428	Deoxynucleoside kinase
CNO12_RS03110	COG0012	GTP binding
CNO12_RS03120	COG0268	Binds directly to 16S ribosomal RNA
CNO12_RS03140	COG0254	rRNA binding
CNO12_RS03155	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CNO12_RS03190	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CNO12_RS03195	COG0581	inorganic phosphate transmembrane transporter activity
CNO12_RS03200	COG0573	inorganic phosphate transmembrane transporter activity
CNO12_RS03210	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CNO12_RS03230	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CNO12_RS03255	COG0742	ribosomal rna small subunit methyltransferase
CNO12_RS03280	COG4536	flavin adenine dinucleotide binding
CNO12_RS03290	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CNO12_RS03295	COG1181	Belongs to the D-alanine--D-alanine ligase family
CNO12_RS03315	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CNO12_RS03325	COG0084	hydrolase, TatD family'
CNO12_RS03340	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CNO12_RS03345	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CNO12_RS03350	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CNO12_RS03365	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CNO12_RS03370	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CNO12_RS03375	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CNO12_RS03400	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CNO12_RS03405	COG0445	tRNA wobble uridine modification
CNO12_RS03410	COG0714	Associated with various cellular activities
CNO12_RS03525	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CNO12_RS03540	COG4175	Glycine betaine
CNO12_RS03545	COG4176	ABC-type proline glycine betaine transport system permease component
CNO12_RS03565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CNO12_RS03580	COG1022	Amp-dependent synthetase and ligase
CNO12_RS03610	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CNO12_RS03630	COG0539	negative regulation of cytoplasmic translation
CNO12_RS03665	COG0233	cytoplasmic translational termination
CNO12_RS03675	COG4589	Belongs to the CDS family
CNO12_RS03690	COG2190	(PTS) system
CNO12_RS03690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CNO12_RS03690	COG1263	PTS System
CNO12_RS03705	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CNO12_RS03710	COG0359	binds to the 23S rRNA
CNO12_RS03715	COG0305	Participates in initiation and elongation during chromosome replication
CNO12_RS03730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CNO12_RS03750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CNO12_RS03775	COG1162	GTPase activity
CNO12_RS03790	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
CNO12_RS03840	COG0606	chelatase, subunit chli
CNO12_RS03870	COG1136	(ABC) transporter
CNO12_RS03875	COG4591	ABC-type transport system involved in lipoprotein release permease component
CNO12_RS03885	COG0552	protein localization to endoplasmic reticulum
CNO12_RS03915	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CNO12_RS03925	COG0561	phosphatase activity
CNO12_RS03930	COG0006	proline dipeptidase activity
CNO12_RS03965	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CNO12_RS04040	COG1196	nuclear chromosome segregation
CNO12_RS04105	COG0681	Belongs to the peptidase S26 family
CNO12_RS04130	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CNO12_RS04140	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CNO12_RS04155	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CNO12_RS04175	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CNO12_RS04210	COG0736	holo-[acyl-carrier-protein] synthase activity
CNO12_RS04240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CNO12_RS04270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CNO12_RS04275	COG1447	Phosphotransferase system cellobiose-specific component IIA
CNO12_RS04280	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CNO12_RS04385	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CNO12_RS04390	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CNO12_RS04395	COG1780	Probably involved in ribonucleotide reductase function
CNO12_RS04400	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CNO12_RS04580	COG1192	Involved in chromosome partitioning
CNO12_RS04915	COG1192	Involved in chromosome partitioning
CNO12_RS05205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CNO12_RS05205	COG2190	(PTS) system
CNO12_RS05205	COG1263	PTS System
CNO12_RS05235	COG2252	PERMEase
CNO12_RS05245	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CNO12_RS05310	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CNO12_RS05320	COG2252	PERMEase
CNO12_RS05350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CNO12_RS05350	COG1263	PTS System
CNO12_RS05350	COG2190	(PTS) system
CNO12_RS06450	COG1192	Involved in chromosome partitioning
CNO12_RS07025	COG1192	Involved in chromosome partitioning