locus-tag	class	description
X966_RS00045	COG0736	holo-[acyl-carrier-protein] synthase activity
X966_RS00055	COG0101	tRNA pseudouridine synthase activity
X966_RS00070	COG0572	uridine kinase
X966_RS00080	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
X966_RS00100	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
X966_RS00110	COG0632	four-way junction helicase activity
X966_RS00115	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
X966_RS00120	COG0217	transcriptional regulatory protein
X966_RS00125	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
X966_RS00150	COG0681	Belongs to the peptidase S26 family
X966_RS00220	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
X966_RS00250	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
X966_RS00265	COG0126	phosphoglycerate kinase activity
X966_RS00285	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
X966_RS00305	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
X966_RS00325	COG0561	phosphatase activity
X966_RS00330	COG2309	aminopeptidase activity
X966_RS00360	COG0552	protein localization to endoplasmic reticulum
X966_RS00370	COG4591	ABC-type transport system involved in lipoprotein release permease component
X966_RS00375	COG1136	(ABC) transporter
X966_RS00405	COG0606	chelatase, subunit chli
X966_RS00410	COG0039	L-malate dehydrogenase activity
X966_RS00415	COG0481	GTPase activity
X966_RS00440	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
X966_RS00445	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
X966_RS00455	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
X966_RS00470	COG1162	GTPase activity
X966_RS00490	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
X966_RS00495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
X966_RS00515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
X966_RS00530	COG0305	Participates in initiation and elongation during chromosome replication
X966_RS00535	COG0359	binds to the 23S rRNA
X966_RS00540	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
X966_RS00550	COG0360	Binds together with S18 to 16S ribosomal RNA
X966_RS00555	COG2190	(PTS) system
X966_RS00555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
X966_RS00555	COG1263	PTS System
X966_RS00570	COG4589	Belongs to the CDS family
X966_RS00580	COG0233	cytoplasmic translational termination
X966_RS00585	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
X966_RS00595	COG0424	maF-like protein
X966_RS00615	COG0539	negative regulation of cytoplasmic translation
X966_RS00620	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
X966_RS00635	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
X966_RS00660	COG0768	penicillin binding
X966_RS00665	COG1022	Amp-dependent synthetase and ligase
X966_RS00675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
X966_RS00700	COG4176	ABC-type proline glycine betaine transport system permease component
X966_RS00720	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
X966_RS00735	COG0653	protein targeting
X966_RS00770	COG0530	calcium, potassium:sodium antiporter activity
X966_RS00830	COG0714	Associated with various cellular activities
X966_RS00835	COG0357	Ribosomal RNA small subunit methyltransferase G
X966_RS00845	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
X966_RS00865	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
X966_RS00875	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
X966_RS00890	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
X966_RS00895	COG0291	Belongs to the bacterial ribosomal protein bL35 family
X966_RS00900	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
X966_RS00915	COG0084	hydrolase, TatD family'
X966_RS00925	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
X966_RS00945	COG1181	Belongs to the D-alanine--D-alanine ligase family
X966_RS00950	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
X966_RS00960	COG4536	flavin adenine dinucleotide binding
X966_RS00985	COG0742	ribosomal rna small subunit methyltransferase
X966_RS01020	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
X966_RS01040	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
X966_RS01050	COG0573	inorganic phosphate transmembrane transporter activity
X966_RS01055	COG0581	inorganic phosphate transmembrane transporter activity
X966_RS01060	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
X966_RS01090	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
X966_RS01095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
X966_RS01130	COG0268	Binds directly to 16S ribosomal RNA
X966_RS01140	COG0012	GTP binding
X966_RS01160	COG1428	Deoxynucleoside kinase
X966_RS01170	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
X966_RS01180	COG2271	Major facilitator Superfamily
X966_RS01185	COG0584	glycerophosphoryl diester phosphodiesterase
X966_RS01205	COG0739	heme binding
X966_RS01210	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
X966_RS01235	COG0495	leucyl-tRNA aminoacylation
X966_RS01245	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
X966_RS01255	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
X966_RS01260	COG0739	heme binding
X966_RS01295	COG0739	heme binding
X966_RS01295	COG1196	nuclear chromosome segregation
X966_RS01295	COG0741	lytic transglycosylase activity
X966_RS01305	COG0443	Heat shock 70 kDa protein
X966_RS01385	COG1360	Flagellar Motor Protein
X966_RS01405	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
X966_RS01455	COG1815	bacterial-type flagellum-dependent cell motility
X966_RS01465	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
X966_RS01490	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
X966_RS01500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
X966_RS01515	COG0275	rRNA processing
X966_RS01535	COG0497	DNA recombination
X966_RS01545	COG0835	chemotaxis
X966_RS01550	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
X966_RS01620	COG4166	transmembrane transport
X966_RS01625	COG0601	transmembrane transport
X966_RS01630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
X966_RS01635	COG0444	Belongs to the ABC transporter superfamily
X966_RS01640	COG4608	Belongs to the ABC transporter superfamily
X966_RS01655	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
X966_RS01660	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
X966_RS01670	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
X966_RS01675	COG0154	amidase activity
X966_RS01695	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
X966_RS01715	COG0227	Belongs to the bacterial ribosomal protein bL28 family
X966_RS01755	COG0793	Belongs to the peptidase S41A family
X966_RS01765	COG0455	bacterial-type flagellum organization
X966_RS01770	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
X966_RS01780	COG1362	aminopeptidase activity
X966_RS01790	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
X966_RS01795	COG0542	response to heat
X966_RS01800	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
X966_RS01825	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
X966_RS01835	COG1854	S-ribosylhomocysteine lyase activity
X966_RS01845	COG2239	Acts as a magnesium transporter
X966_RS01865	COG1744	ABC transporter substrate-binding protein PnrA-like
X966_RS01875	COG0049	tRNA binding
X966_RS01880	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
X966_RS01885	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
X966_RS01890	COG0085	RNA polymerase activity
X966_RS01895	COG0222	ribosome binding
X966_RS01900	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
X966_RS01905	COG0081	regulation of translation
X966_RS01910	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
X966_RS01930	COG0267	Belongs to the bacterial ribosomal protein bL33 family
X966_RS01985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
X966_RS01985	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
X966_RS01985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
X966_RS02000	COG0170	dolichyl monophosphate biosynthetic process
X966_RS02005	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
X966_RS02025	COG0563	adenylate kinase activity
X966_RS02055	COG0561	phosphatase activity
X966_RS02065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
X966_RS02070	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
X966_RS02095	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
X966_RS02100	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
X966_RS02120	COG1192	Involved in chromosome partitioning
X966_RS02140	COG0187	DNA topoisomerase II activity
X966_RS02145	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
X966_RS02155	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
X966_RS02165	COG0230	Belongs to the bacterial ribosomal protein bL34 family
X966_RS02170	COG0594	ribonuclease P activity
X966_RS02175	COG0706	membrane insertase activity
X966_RS02200	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
X966_RS02205	COG0475	glutathione-regulated potassium exporter activity
X966_RS02225	COG2059	Chromate
X966_RS02235	COG0668	transmembrane transport
X966_RS02250	COG0322	excinuclease ABC activity
X966_RS02290	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
X966_RS02295	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
X966_RS02300	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
X966_RS02325	COG1137	ATPase activity
X966_RS02340	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
X966_RS02355	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
X966_RS02360	COG0534	Mate efflux family protein
X966_RS02370	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
X966_RS02375	COG0051	transcription antitermination factor activity, RNA binding
X966_RS02380	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
X966_RS02385	COG0088	Forms part of the polypeptide exit tunnel
X966_RS02395	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
X966_RS02400	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
X966_RS02405	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
X966_RS02410	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
X966_RS02415	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
X966_RS02420	COG0255	Belongs to the universal ribosomal protein uL29 family
X966_RS02425	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
X966_RS02430	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
X966_RS02435	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
X966_RS02440	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
X966_RS02445	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
X966_RS02450	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
X966_RS02455	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
X966_RS02460	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
X966_RS02485	COG0257	Belongs to the bacterial ribosomal protein bL36 family
X966_RS02490	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
X966_RS02500	COG0202	RNA polymerase activity
X966_RS02505	COG0203	ribosomal protein L17
X966_RS02515	COG1692	metallophosphoesterase
X966_RS02520	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
X966_RS02530	COG1160	GTP binding
X966_RS02555	COG0072	phenylalanine-tRNA ligase activity
X966_RS02590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
X966_RS02590	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
X966_RS02595	COG2208	phosphoserine phosphatase activity
X966_RS02630	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
X966_RS02630	COG0321	lipoyl(octanoyl) transferase activity
X966_RS02635	COG0708	Exodeoxyribonuclease III
X966_RS02645	COG0612	Peptidase, M16
X966_RS02685	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
X966_RS02715	COG1070	Carbohydrate kinase
X966_RS02745	COG2201	protein-glutamate methylesterase activity
X966_RS02750	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
X966_RS02795	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
X966_RS02815	COG0835	chemotaxis
X966_RS02825	COG0643	Histidine kinase
X966_RS02825	COG2198	Histidine kinase
X966_RS02840	COG0784	Response regulator, receiver
X966_RS02840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
X966_RS02840	COG2198	Histidine kinase
X966_RS02840	COG2205	protein histidine kinase activity
X966_RS02845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
X966_RS02855	COG0528	UMP kinase activity
X966_RS02860	COG1216	Glycosyl transferase, family 2
X966_RS02865	COG4555	ABC transporter
X966_RS02875	COG0504	CTP synthase activity
X966_RS02885	COG0840	transmembrane signaling receptor activity
X966_RS02885	COG3290	protein histidine kinase activity
X966_RS02910	COG0534	Mate efflux family protein
X966_RS02930	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
X966_RS02930	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
X966_RS02940	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
X966_RS02955	COG1022	Amp-dependent synthetase and ligase
X966_RS02960	COG0018	arginyl-trna synthetase
X966_RS02970	COG0840	transmembrane signaling receptor activity
X966_RS02975	COG5278	phosphoserine phosphatase activity
X966_RS02975	COG0840	transmembrane signaling receptor activity
X966_RS02985	COG0215	cysteine-tRNA ligase activity
X966_RS02995	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
X966_RS03000	COG0484	heat shock protein binding
X966_RS03010	COG1620	l-lactate permease
X966_RS03015	COG1686	Belongs to the peptidase S11 family
X966_RS03020	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
X966_RS03025	COG2195	Cleaves the N-terminal amino acid of tripeptides
X966_RS03050	COG0544	peptidyl-prolyl cis-trans isomerase activity
X966_RS03055	COG0740	serine-type endopeptidase activity
X966_RS03060	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
X966_RS03070	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
X966_RS03110	COG0693	protein deglycase activity
X966_RS03115	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
X966_RS03130	COG0860	N-Acetylmuramoyl-L-alanine amidase
X966_RS03155	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
X966_RS03155	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
X966_RS03155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
X966_RS03170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
X966_RS03180	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
X966_RS03185	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
X966_RS03195	COG1757	Na H antiporter
X966_RS03205	COG1177	transmembrane transport
X966_RS03210	COG1176	ABC-type spermidine putrescine transport system, permease component I
X966_RS03220	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
X966_RS03225	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
X966_RS03230	COG2190	(PTS) system
X966_RS03230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
X966_RS03230	COG1263	PTS System
X966_RS03250	COG0459	protein refolding
X966_RS03280	COG0484	heat shock protein binding
X966_RS03285	COG0635	Involved in the biosynthesis of porphyrin-containing compound
X966_RS03295	COG0588	phosphoglycerate mutase activity
X966_RS03305	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
X966_RS03335	COG0860	N-Acetylmuramoyl-L-alanine amidase
X966_RS03335	COG1388	LysM domain
X966_RS03355	COG0835	chemotaxis
X966_RS03365	COG2201	protein-glutamate methylesterase activity
X966_RS03385	COG0546	phosphoglycolate phosphatase activity
X966_RS03390	COG3845	ABC transporter
X966_RS03395	COG4603	Belongs to the binding-protein-dependent transport system permease family
X966_RS03400	COG1079	Belongs to the binding-protein-dependent transport system permease family
X966_RS03405	COG0840	transmembrane signaling receptor activity
X966_RS03410	COG0840	transmembrane signaling receptor activity
X966_RS03415	COG0482	sulfurtransferase activity
X966_RS03420	COG3425	synthase
X966_RS03425	COG1304	FMN binding
X966_RS03465	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
X966_RS03475	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
X966_RS03480	COG0228	four-way junction DNA binding
X966_RS03495	COG0336	Belongs to the RNA methyltransferase TrmD family
X966_RS03500	COG0335	large ribosomal subunit rRNA binding
X966_RS03520	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
X966_RS03525	COG0333	Belongs to the bacterial ribosomal protein bL32 family
X966_RS03530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
X966_RS03535	COG0571	ribonuclease III activity
X966_RS03565	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
X966_RS03590	COG1077	Cell shape determining protein MreB Mrl
X966_RS03605	COG0768	penicillin binding
X966_RS03610	COG0772	Belongs to the SEDS family
X966_RS03615	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
X966_RS03635	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
X966_RS03645	COG0489	protein tyrosine kinase activity
X966_RS03655	COG0446	pyridine nucleotide-disulphide oxidoreductase
X966_RS03670	COG1475	DNA binding
X966_RS03690	COG0009	L-threonylcarbamoyladenylate synthase
X966_RS03695	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
X966_RS03700	COG1199	ATP-dependent helicase activity
X966_RS03710	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
X966_RS03720	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
X966_RS03720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X966_RS03725	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
X966_RS03730	COG0488	(ABC) transporter
X966_RS03760	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
X966_RS03770	COG0601	transmembrane transport
X966_RS03805	COG1131	(ABC) transporter
X966_RS03810	COG1234	tRNA 3'-trailer cleavage
X966_RS03815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X966_RS03815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X966_RS03840	COG0739	heme binding
X966_RS03845	COG2204	response regulator
X966_RS03850	COG3852	Histidine kinase
X966_RS03855	COG0470	DNA polymerase III
X966_RS03865	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
X966_RS03870	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
X966_RS03875	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
X966_RS03885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
X966_RS03890	COG3951	Flagellar rod assembly protein muramidase FlgJ
X966_RS03935	COG0211	Belongs to the bacterial ribosomal protein bL27 family
X966_RS03940	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
X966_RS03945	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
X966_RS03960	COG2088	sporulation resulting in formation of a cellular spore
X966_RS03970	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
X966_RS03975	COG0193	aminoacyl-tRNA hydrolase activity
X966_RS03995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
X966_RS04010	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
X966_RS04020	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
X966_RS04035	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
X966_RS04040	COG1040	competence protein
X966_RS04045	COG0779	Required for maturation of 30S ribosomal subunits
X966_RS04055	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
X966_RS04065	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
X966_RS04070	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
X966_RS04075	COG1185	polyribonucleotide nucleotidyltransferase activity
X966_RS04095	COG0343	queuine tRNA-ribosyltransferase activity
X966_RS04115	COG4145	pantothenate transmembrane transporter activity
X966_RS04130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
X966_RS04140	COG1102	Psort location Cytoplasmic, score
X966_RS04150	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
X966_RS04175	COG2190	(PTS) system
X966_RS04175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
X966_RS04175	COG1263	PTS System
X966_RS04200	COG1940	carbohydrate kinase activity
X966_RS04205	COG3142	Participates in the control of copper homeostasis
X966_RS04215	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
X966_RS04225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
X966_RS04260	COG2235	arginine
X966_RS04270	COG1288	antiporter activity
X966_RS04275	COG0549	Belongs to the carbamate kinase family