locus-tag	class	description
A7978_RS00050	COG0736	holo-[acyl-carrier-protein] synthase activity
A7978_RS00060	COG0101	tRNA pseudouridine synthase activity
A7978_RS00075	COG0572	uridine kinase
A7978_RS00085	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A7978_RS00105	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A7978_RS00115	COG0632	four-way junction helicase activity
A7978_RS00120	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A7978_RS00125	COG0217	transcriptional regulatory protein
A7978_RS00130	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A7978_RS00155	COG0681	Belongs to the peptidase S26 family
A7978_RS00220	COG1196	nuclear chromosome segregation
A7978_RS00260	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A7978_RS00275	COG0126	phosphoglycerate kinase activity
A7978_RS00295	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A7978_RS00315	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A7978_RS00335	COG0561	phosphatase activity
A7978_RS00340	COG2309	aminopeptidase activity
A7978_RS00375	COG0552	protein localization to endoplasmic reticulum
A7978_RS00385	COG4591	ABC-type transport system involved in lipoprotein release permease component
A7978_RS00390	COG1136	(ABC) transporter
A7978_RS00420	COG0606	chelatase, subunit chli
A7978_RS00425	COG0039	L-malate dehydrogenase activity
A7978_RS00430	COG0481	GTPase activity
A7978_RS00455	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
A7978_RS00460	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
A7978_RS00470	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
A7978_RS00485	COG1162	GTPase activity
A7978_RS00505	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A7978_RS00510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A7978_RS00530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A7978_RS00545	COG0305	Participates in initiation and elongation during chromosome replication
A7978_RS00550	COG0359	binds to the 23S rRNA
A7978_RS00555	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A7978_RS00565	COG0360	Binds together with S18 to 16S ribosomal RNA
A7978_RS00570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7978_RS00570	COG1263	PTS System
A7978_RS00570	COG2190	(PTS) system
A7978_RS00585	COG4589	Belongs to the CDS family
A7978_RS00595	COG0233	cytoplasmic translational termination
A7978_RS00600	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A7978_RS00605	COG0052	Belongs to the universal ribosomal protein uS2 family
A7978_RS00630	COG0539	negative regulation of cytoplasmic translation
A7978_RS00635	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A7978_RS00650	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A7978_RS00675	COG0768	penicillin binding
A7978_RS00680	COG1022	Amp-dependent synthetase and ligase
A7978_RS00715	COG4176	ABC-type proline glycine betaine transport system permease component
A7978_RS00735	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A7978_RS00790	COG0530	calcium, potassium:sodium antiporter activity
A7978_RS00850	COG0714	Associated with various cellular activities
A7978_RS00855	COG0357	Ribosomal RNA small subunit methyltransferase G
A7978_RS00865	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A7978_RS00885	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
A7978_RS00890	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A7978_RS00895	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A7978_RS00910	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A7978_RS00915	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A7978_RS00920	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A7978_RS00935	COG0084	hydrolase, TatD family'
A7978_RS00945	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A7978_RS00965	COG1181	Belongs to the D-alanine--D-alanine ligase family
A7978_RS00970	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A7978_RS00980	COG4536	flavin adenine dinucleotide binding
A7978_RS01005	COG0742	ribosomal rna small subunit methyltransferase
A7978_RS01030	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A7978_RS01050	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A7978_RS01060	COG0573	inorganic phosphate transmembrane transporter activity
A7978_RS01065	COG0581	inorganic phosphate transmembrane transporter activity
A7978_RS01070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A7978_RS01100	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A7978_RS01105	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A7978_RS01140	COG0268	Binds directly to 16S ribosomal RNA
A7978_RS01150	COG0012	GTP binding
A7978_RS01170	COG1428	Deoxynucleoside kinase
A7978_RS01180	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A7978_RS01190	COG2271	Major facilitator Superfamily
A7978_RS01195	COG0584	glycerophosphoryl diester phosphodiesterase
A7978_RS01200	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A7978_RS01215	COG0739	heme binding
A7978_RS01220	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A7978_RS01245	COG0495	leucyl-tRNA aminoacylation
A7978_RS01255	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A7978_RS01265	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A7978_RS01270	COG0739	heme binding
A7978_RS01305	COG0741	lytic transglycosylase activity
A7978_RS01305	COG0739	heme binding
A7978_RS01305	COG1196	nuclear chromosome segregation
A7978_RS01315	COG0443	Heat shock 70 kDa protein
A7978_RS01395	COG1360	Flagellar Motor Protein
A7978_RS01415	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A7978_RS01465	COG1815	bacterial-type flagellum-dependent cell motility
A7978_RS01475	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A7978_RS01510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A7978_RS01525	COG0275	rRNA processing
A7978_RS01545	COG0497	DNA recombination
A7978_RS01555	COG0835	chemotaxis
A7978_RS01560	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A7978_RS01630	COG4166	transmembrane transport
A7978_RS01635	COG0601	transmembrane transport
A7978_RS01640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7978_RS01645	COG0444	Belongs to the ABC transporter superfamily
A7978_RS01650	COG4608	Belongs to the ABC transporter superfamily
A7978_RS01665	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A7978_RS01670	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A7978_RS01680	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A7978_RS01685	COG0154	amidase activity
A7978_RS01705	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A7978_RS01725	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A7978_RS01765	COG0793	Belongs to the peptidase S41A family
A7978_RS01775	COG0455	bacterial-type flagellum organization
A7978_RS01780	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A7978_RS01800	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A7978_RS01805	COG0542	response to heat
A7978_RS01810	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A7978_RS01835	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A7978_RS01845	COG1854	S-ribosylhomocysteine lyase activity
A7978_RS01855	COG2239	Acts as a magnesium transporter
A7978_RS01885	COG0049	tRNA binding
A7978_RS01890	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A7978_RS01895	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A7978_RS01900	COG0085	RNA polymerase activity
A7978_RS01905	COG0222	ribosome binding
A7978_RS01910	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A7978_RS01915	COG0081	regulation of translation
A7978_RS01920	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A7978_RS01940	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A7978_RS02000	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7978_RS02000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7978_RS02000	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7978_RS02025	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A7978_RS02045	COG0563	adenylate kinase activity
A7978_RS02075	COG0561	phosphatase activity
A7978_RS02085	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A7978_RS02090	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A7978_RS02095	COG2094	Belongs to the DNA glycosylase MPG family
A7978_RS02115	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A7978_RS02120	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A7978_RS02140	COG1192	Involved in chromosome partitioning
A7978_RS02160	COG0187	DNA topoisomerase II activity
A7978_RS02165	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A7978_RS02175	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A7978_RS02185	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A7978_RS02190	COG0594	ribonuclease P activity
A7978_RS02195	COG0706	membrane insertase activity
A7978_RS02220	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A7978_RS02225	COG0475	glutathione-regulated potassium exporter activity
A7978_RS02245	COG2059	Chromate
A7978_RS02255	COG0668	transmembrane transport
A7978_RS02270	COG0322	excinuclease ABC activity
A7978_RS02315	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A7978_RS02320	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A7978_RS02325	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A7978_RS02350	COG1137	ATPase activity
A7978_RS02365	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A7978_RS02385	COG0534	Mate efflux family protein
A7978_RS02395	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A7978_RS02400	COG0051	transcription antitermination factor activity, RNA binding
A7978_RS02405	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A7978_RS02410	COG0088	Forms part of the polypeptide exit tunnel
A7978_RS02420	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A7978_RS02425	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A7978_RS02430	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A7978_RS02435	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A7978_RS02440	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A7978_RS02445	COG0255	Belongs to the universal ribosomal protein uL29 family
A7978_RS02450	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A7978_RS02455	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A7978_RS02460	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A7978_RS02465	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A7978_RS02470	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A7978_RS02475	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A7978_RS02480	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A7978_RS02485	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A7978_RS02510	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A7978_RS02515	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A7978_RS02525	COG0202	RNA polymerase activity
A7978_RS02530	COG0203	ribosomal protein L17
A7978_RS02540	COG1692	metallophosphoesterase
A7978_RS02545	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A7978_RS02555	COG1160	GTP binding
A7978_RS02580	COG0072	phenylalanine-tRNA ligase activity
A7978_RS02610	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A7978_RS02610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7978_RS02615	COG2208	phosphoserine phosphatase activity
A7978_RS02650	COG0321	lipoyl(octanoyl) transferase activity
A7978_RS02650	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A7978_RS02655	COG0708	Exodeoxyribonuclease III
A7978_RS02665	COG0612	Peptidase, M16
A7978_RS02735	COG1070	Carbohydrate kinase
A7978_RS02765	COG2201	protein-glutamate methylesterase activity
A7978_RS02770	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A7978_RS02815	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A7978_RS02835	COG0835	chemotaxis
A7978_RS02845	COG2198	Histidine kinase
A7978_RS02845	COG0643	Histidine kinase
A7978_RS02860	COG2198	Histidine kinase
A7978_RS02860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7978_RS02860	COG0784	Response regulator, receiver
A7978_RS02860	COG2205	protein histidine kinase activity
A7978_RS02865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7978_RS02875	COG0528	UMP kinase activity
A7978_RS02880	COG1216	Glycosyl transferase, family 2
A7978_RS02885	COG4555	ABC transporter
A7978_RS02895	COG0504	CTP synthase activity
A7978_RS02905	COG3290	protein histidine kinase activity
A7978_RS02905	COG0840	transmembrane signaling receptor activity
A7978_RS02930	COG0534	Mate efflux family protein
A7978_RS02945	COG2348	transferase activity, transferring amino-acyl groups
A7978_RS02950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7978_RS02950	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7978_RS02960	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A7978_RS02975	COG1022	Amp-dependent synthetase and ligase
A7978_RS02980	COG0018	arginyl-trna synthetase
A7978_RS02990	COG0840	transmembrane signaling receptor activity
A7978_RS02995	COG0840	transmembrane signaling receptor activity
A7978_RS02995	COG5278	phosphoserine phosphatase activity
A7978_RS03005	COG0215	cysteine-tRNA ligase activity
A7978_RS03015	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A7978_RS03020	COG0484	heat shock protein binding
A7978_RS03030	COG1620	l-lactate permease
A7978_RS03035	COG1686	Belongs to the peptidase S11 family
A7978_RS03040	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A7978_RS03045	COG2195	Cleaves the N-terminal amino acid of tripeptides
A7978_RS03070	COG0544	peptidyl-prolyl cis-trans isomerase activity
A7978_RS03075	COG0740	serine-type endopeptidase activity
A7978_RS03080	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A7978_RS03090	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A7978_RS03130	COG0693	protein deglycase activity
A7978_RS03135	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A7978_RS03150	COG1388	LysM domain
A7978_RS03150	COG1705	Flagellar rod assembly protein muramidase FlgJ
A7978_RS03175	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7978_RS03175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7978_RS03175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7978_RS03190	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A7978_RS03200	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A7978_RS03205	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A7978_RS03220	COG1757	Na H antiporter
A7978_RS03230	COG1177	transmembrane transport
A7978_RS03235	COG1176	ABC-type spermidine putrescine transport system, permease component I
A7978_RS03250	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
A7978_RS03255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7978_RS03255	COG1263	PTS System
A7978_RS03255	COG2190	(PTS) system
A7978_RS03275	COG0459	protein refolding
A7978_RS03305	COG0484	heat shock protein binding
A7978_RS03310	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A7978_RS03320	COG0588	phosphoglycerate mutase activity
A7978_RS03330	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A7978_RS03380	COG0835	chemotaxis
A7978_RS03390	COG2201	protein-glutamate methylesterase activity
A7978_RS03410	COG0546	phosphoglycolate phosphatase activity
A7978_RS03415	COG3845	ABC transporter
A7978_RS03420	COG4603	Belongs to the binding-protein-dependent transport system permease family
A7978_RS03425	COG1079	Belongs to the binding-protein-dependent transport system permease family
A7978_RS03430	COG0840	transmembrane signaling receptor activity
A7978_RS03435	COG0840	transmembrane signaling receptor activity
A7978_RS03440	COG0482	sulfurtransferase activity
A7978_RS03445	COG3425	synthase
A7978_RS03450	COG1304	FMN binding
A7978_RS03490	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A7978_RS03500	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A7978_RS03505	COG0228	four-way junction DNA binding
A7978_RS03520	COG0336	Belongs to the RNA methyltransferase TrmD family
A7978_RS03525	COG0335	large ribosomal subunit rRNA binding
A7978_RS03545	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A7978_RS03550	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A7978_RS03555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7978_RS03560	COG0571	ribonuclease III activity
A7978_RS03565	COG0617	tRNA 3'-terminal CCA addition
A7978_RS03590	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A7978_RS03620	COG1077	Cell shape determining protein MreB Mrl
A7978_RS03635	COG0768	penicillin binding
A7978_RS03640	COG0772	Belongs to the SEDS family
A7978_RS03645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A7978_RS03665	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A7978_RS03675	COG0489	protein tyrosine kinase activity
A7978_RS03685	COG0446	pyridine nucleotide-disulphide oxidoreductase
A7978_RS03700	COG1475	DNA binding
A7978_RS03720	COG0009	L-threonylcarbamoyladenylate synthase
A7978_RS03725	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A7978_RS03730	COG1199	ATP-dependent helicase activity
A7978_RS03740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A7978_RS03750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7978_RS03750	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A7978_RS03755	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A7978_RS03760	COG0488	(ABC) transporter
A7978_RS03785	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A7978_RS03795	COG0601	transmembrane transport
A7978_RS03830	COG1131	(ABC) transporter
A7978_RS03835	COG1234	tRNA 3'-trailer cleavage
A7978_RS03840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7978_RS03870	COG0739	heme binding
A7978_RS03875	COG2204	response regulator
A7978_RS03880	COG3852	Histidine kinase
A7978_RS03885	COG0470	DNA polymerase III
A7978_RS03895	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A7978_RS03900	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A7978_RS03905	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A7978_RS03915	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A7978_RS03920	COG3951	Flagellar rod assembly protein muramidase FlgJ
A7978_RS03965	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A7978_RS03970	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A7978_RS03975	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A7978_RS03990	COG2088	sporulation resulting in formation of a cellular spore
A7978_RS04000	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A7978_RS04005	COG0193	aminoacyl-tRNA hydrolase activity
A7978_RS04025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A7978_RS04040	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A7978_RS04050	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A7978_RS04065	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A7978_RS04070	COG1040	competence protein
A7978_RS04075	COG0779	Required for maturation of 30S ribosomal subunits
A7978_RS04085	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A7978_RS04100	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A7978_RS04105	COG1185	polyribonucleotide nucleotidyltransferase activity
A7978_RS04125	COG0343	queuine tRNA-ribosyltransferase activity
A7978_RS04150	COG4145	pantothenate transmembrane transporter activity
A7978_RS04165	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A7978_RS04175	COG1102	Psort location Cytoplasmic, score
A7978_RS04185	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A7978_RS04210	COG2190	(PTS) system
A7978_RS04210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7978_RS04210	COG1263	PTS System
A7978_RS04235	COG1940	carbohydrate kinase activity
A7978_RS04240	COG3142	Participates in the control of copper homeostasis
A7978_RS04250	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A7978_RS04260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A7978_RS04295	COG2235	arginine
A7978_RS04305	COG1288	antiporter activity
A7978_RS04310	COG0549	Belongs to the carbamate kinase family
A7978_RS04625	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A7978_RS04630	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A7978_RS04635	COG1780	Probably involved in ribonucleotide reductase function
A7978_RS04640	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
A7978_RS04875	COG1192	Involved in chromosome partitioning
A7978_RS05285	COG1192	Involved in chromosome partitioning
A7978_RS05435	COG1192	Involved in chromosome partitioning
A7978_RS05665	COG1192	Involved in chromosome partitioning
A7978_RS05790	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A7978_RS05805	COG2252	PERMEase
A7978_RS05835	COG1263	PTS System
A7978_RS05835	COG2190	(PTS) system
A7978_RS05835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7978_RS05840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7978_RS05840	COG1263	PTS System
A7978_RS05840	COG2190	(PTS) system
A7978_RS06135	COG1192	Involved in chromosome partitioning