locus-tag	class	description
B1U21_RS00020	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B1U21_RS00025	COG1447	Phosphotransferase system cellobiose-specific component IIA
B1U21_RS00030	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B1U21_RS00100	COG2252	PERMEase
B1U21_RS00105	COG2252	PERMEase
B1U21_RS00135	COG1263	PTS System
B1U21_RS00135	COG2190	(PTS) system
B1U21_RS00135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B1U21_RS00295	COG1192	Involved in chromosome partitioning
B1U21_RS00510	COG1192	Involved in chromosome partitioning
B1U21_RS00730	COG1192	Involved in chromosome partitioning
B1U21_RS00955	COG1192	Involved in chromosome partitioning
B1U21_RS01165	COG1192	Involved in chromosome partitioning
B1U21_RS01610	COG1192	Involved in chromosome partitioning
B1U21_RS01665	COG1192	Involved in chromosome partitioning
B1U21_RS01740	COG1192	Involved in chromosome partitioning
B1U21_RS01945	COG1192	Involved in chromosome partitioning
B1U21_RS01985	COG1136	(ABC) transporter
B1U21_RS02155	COG1192	Involved in chromosome partitioning
B1U21_RS02200	COG4166	transmembrane transport
B1U21_RS02760	COG1472	Belongs to the glycosyl hydrolase 3 family
B1U21_RS02770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B1U21_RS02835	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B1U21_RS02905	COG0681	Belongs to the peptidase S26 family
B1U21_RS02970	COG1196	nuclear chromosome segregation
B1U21_RS02995	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B1U21_RS03085	COG0561	phosphatase activity
B1U21_RS03090	COG2309	aminopeptidase activity
B1U21_RS03095	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
B1U21_RS03125	COG0552	protein localization to endoplasmic reticulum
B1U21_RS03135	COG4591	ABC-type transport system involved in lipoprotein release permease component
B1U21_RS03140	COG1136	(ABC) transporter
B1U21_RS03170	COG0606	chelatase, subunit chli
B1U21_RS03260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1U21_RS03295	COG0305	Participates in initiation and elongation during chromosome replication
B1U21_RS03320	COG2190	(PTS) system
B1U21_RS03320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B1U21_RS03320	COG1263	PTS System
B1U21_RS03335	COG4589	Belongs to the CDS family
B1U21_RS03375	COG0539	negative regulation of cytoplasmic translation
B1U21_RS03420	COG0768	penicillin binding
B1U21_RS03425	COG1022	Amp-dependent synthetase and ligase
B1U21_RS03465	COG4176	ABC-type proline glycine betaine transport system permease component
B1U21_RS03470	COG3448	diguanylate cyclase activity
B1U21_RS03470	COG4175	Glycine betaine
B1U21_RS03485	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B1U21_RS03610	COG0714	Associated with various cellular activities
B1U21_RS03655	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B1U21_RS03695	COG0084	hydrolase, TatD family'
B1U21_RS03740	COG4536	flavin adenine dinucleotide binding
B1U21_RS03770	COG0742	ribosomal rna small subunit methyltransferase
B1U21_RS03775	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B1U21_RS03825	COG0573	inorganic phosphate transmembrane transporter activity
B1U21_RS03830	COG0581	inorganic phosphate transmembrane transporter activity
B1U21_RS03850	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B1U21_RS03870	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B1U21_RS03920	COG0012	GTP binding
B1U21_RS03940	COG1428	Deoxynucleoside kinase
B1U21_RS03945	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B1U21_RS03960	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B1U21_RS03975	COG0739	heme binding
B1U21_RS04020	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B1U21_RS04025	COG0739	heme binding
B1U21_RS04065	COG0681	Belongs to the peptidase S26 family
B1U21_RS04070	COG0443	Heat shock 70 kDa protein
B1U21_RS04150	COG1360	Flagellar Motor Protein
B1U21_RS04160	COG1582	Flagellar protein (FlbD)
B1U21_RS04170	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B1U21_RS04255	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B1U21_RS04305	COG0835	chemotaxis
B1U21_RS04400	COG0601	transmembrane transport
B1U21_RS04405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1U21_RS04410	COG0444	Belongs to the ABC transporter superfamily
B1U21_RS04415	COG4608	Belongs to the ABC transporter superfamily
B1U21_RS04460	COG0210	DNA helicase
B1U21_RS04530	COG0793	Belongs to the peptidase S41A family
B1U21_RS04540	COG0455	bacterial-type flagellum organization
B1U21_RS04575	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B1U21_RS04580	COG0542	response to heat
B1U21_RS04610	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B1U21_RS04635	COG2239	Acts as a magnesium transporter
B1U21_RS04785	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B1U21_RS04785	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B1U21_RS04785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B1U21_RS04865	COG0561	phosphatase activity
B1U21_RS04900	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B1U21_RS04915	COG1739	Uncharacterized protein family UPF0029
B1U21_RS04920	COG1192	Involved in chromosome partitioning
B1U21_RS05015	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B1U21_RS05030	COG0668	transmembrane transport
B1U21_RS05095	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B1U21_RS05120	COG1137	ATPase activity
B1U21_RS05280	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B1U21_RS05310	COG1692	metallophosphoesterase
B1U21_RS05315	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
B1U21_RS05380	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B1U21_RS05380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B1U21_RS05405	COG0667	Aldo Keto reductase
B1U21_RS05425	COG0321	lipoyl(octanoyl) transferase activity
B1U21_RS05425	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B1U21_RS05430	COG0708	Exodeoxyribonuclease III
B1U21_RS05440	COG0612	Peptidase, M16
B1U21_RS05525	COG2201	protein-glutamate methylesterase activity
B1U21_RS05575	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B1U21_RS05595	COG0835	chemotaxis
B1U21_RS05605	COG2198	Histidine kinase
B1U21_RS05605	COG0643	Histidine kinase
B1U21_RS05620	COG4566	intracellular signal transduction
B1U21_RS05630	COG0528	UMP kinase activity
B1U21_RS05635	COG1216	Glycosyl transferase, family 2
B1U21_RS05640	COG1121	(ABC) transporter
B1U21_RS05665	COG0840	transmembrane signaling receptor activity
B1U21_RS05665	COG3290	protein histidine kinase activity
B1U21_RS05690	COG0534	Mate efflux family protein
B1U21_RS05710	COG2348	transferase activity, transferring amino-acyl groups
B1U21_RS05720	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B1U21_RS05735	COG2333	competence protein COMEC
B1U21_RS05735	COG0658	competence protein
B1U21_RS05745	COG1022	Amp-dependent synthetase and ligase
B1U21_RS05760	COG0840	transmembrane signaling receptor activity
B1U21_RS05765	COG0840	transmembrane signaling receptor activity
B1U21_RS05765	COG5278	phosphoserine phosphatase activity
B1U21_RS05790	COG0484	heat shock protein binding
B1U21_RS05800	COG1620	l-lactate permease
B1U21_RS05805	COG1686	Belongs to the peptidase S11 family
B1U21_RS05815	COG0210	DNA helicase
B1U21_RS05820	COG2195	Cleaves the N-terminal amino acid of tripeptides
B1U21_RS05890	COG0295	cytidine deaminase activity
B1U21_RS05930	COG3103	Sh3 type 3 domain protein
B1U21_RS05930	COG0791	NLP P60 protein
B1U21_RS05930	COG1388	LysM domain
B1U21_RS05955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B1U21_RS05955	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B1U21_RS05955	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B1U21_RS05975	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B1U21_RS05990	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B1U21_RS06005	COG1757	Na H antiporter
B1U21_RS06015	COG1177	transmembrane transport
B1U21_RS06020	COG1176	ABC-type spermidine putrescine transport system, permease component I
B1U21_RS06030	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B1U21_RS06040	COG1263	PTS System
B1U21_RS06040	COG2190	(PTS) system
B1U21_RS06040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B1U21_RS06090	COG0484	heat shock protein binding
B1U21_RS06095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B1U21_RS06145	COG0860	N-Acetylmuramoyl-L-alanine amidase
B1U21_RS06165	COG0835	chemotaxis
B1U21_RS06175	COG2201	protein-glutamate methylesterase activity
B1U21_RS06200	COG3845	ABC transporter
B1U21_RS06205	COG4603	Belongs to the binding-protein-dependent transport system permease family
B1U21_RS06210	COG1079	Belongs to the binding-protein-dependent transport system permease family
B1U21_RS06215	COG0840	transmembrane signaling receptor activity
B1U21_RS06220	COG0840	transmembrane signaling receptor activity
B1U21_RS06230	COG3425	synthase
B1U21_RS06270	COG0783	Belongs to the Dps family
B1U21_RS06285	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B1U21_RS06340	COG0617	tRNA 3'-terminal CCA addition
B1U21_RS06365	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B1U21_RS06395	COG1077	Cell shape determining protein MreB Mrl
B1U21_RS06410	COG0768	penicillin binding
B1U21_RS06415	COG0772	Belongs to the SEDS family
B1U21_RS06425	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B1U21_RS06440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B1U21_RS06450	COG0003	Pfam Anion-transporting ATPase
B1U21_RS06460	COG0446	pyridine nucleotide-disulphide oxidoreductase
B1U21_RS06475	COG1475	DNA binding
B1U21_RS06490	COG0009	L-threonylcarbamoyladenylate synthase
B1U21_RS06495	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B1U21_RS06515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1U21_RS06515	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
B1U21_RS06525	COG0488	(ABC) transporter
B1U21_RS06550	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B1U21_RS06555	COG4239	(ABC) transporter, permease
B1U21_RS06560	COG0601	transmembrane transport
B1U21_RS06590	COG1131	(ABC) transporter
B1U21_RS06600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1U21_RS06630	COG0739	heme binding
B1U21_RS06635	COG2204	response regulator
B1U21_RS06640	COG5002	protein histidine kinase activity
B1U21_RS06645	COG0470	DNA polymerase III
B1U21_RS06675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B1U21_RS06795	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B1U21_RS06805	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B1U21_RS06820	COG1040	competence protein
B1U21_RS06895	COG4145	pantothenate transmembrane transporter activity
B1U21_RS06900	COG0564	pseudouridine synthase activity
B1U21_RS06915	COG1561	YicC-like family, N-terminal region
B1U21_RS06970	COG0419	ATPase involved in DNA repair
B1U21_RS06975	COG1940	carbohydrate kinase activity
B1U21_RS06995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B1U21_RS07040	COG1288	antiporter activity