locus-tag	class	description
CE453_RS00030	COG2205	protein histidine kinase activity
CE453_RS00040	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
CE453_RS00050	COG3504	Conjugal transfer protein
CE453_RS00085	COG3451	type IV secretory pathway VirB4
CE453_RS00165	COG1192	Involved in chromosome partitioning
CE453_RS00170	COG1475	DNA binding
CE453_RS00175	COG0640	Transcriptional regulator
CE453_RS00180	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CE453_RS00235	COG3621	Patatin-like phospholipase
CE453_RS00265	COG1393	Belongs to the ArsC family
CE453_RS00270	COG0798	PFAM Bile acid sodium symporter
CE453_RS00310	COG3034	peptidoglycan biosynthetic process
CE453_RS00320	COG0798	PFAM Bile acid sodium symporter
CE453_RS00385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CE453_RS00385	COG3453	Protein conserved in bacteria
CE453_RS00390	COG0640	Transcriptional regulator
CE453_RS00415	COG1999	signal sequence binding
CE453_RS00425	COG3034	peptidoglycan biosynthetic process
CE453_RS00445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CE453_RS00450	COG0785	Cytochrome C biogenesis protein
CE453_RS00455	COG1278	Cold shock
CE453_RS00465	COG4957	zinc ion binding
CE453_RS00495	COG1131	(ABC) transporter
CE453_RS00515	COG5002	protein histidine kinase activity
CE453_RS00540	COG4191	Histidine kinase
CE453_RS00545	COG2204	response regulator
CE453_RS00600	COG2217	Heavy metal translocating P-type atpase
CE453_RS00605	COG2217	Heavy metal translocating P-type atpase
CE453_RS00610	COG0450	alkyl hydroperoxide reductase
CE453_RS00625	COG0789	Transcriptional regulator
CE453_RS00650	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CE453_RS00710	COG2944	sequence-specific DNA binding
CE453_RS00720	COG1475	DNA binding
CE453_RS00765	COG4974	Belongs to the 'phage' integrase family
CE453_RS00785	COG4227	nucleotidyltransferase activity
CE453_RS00810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CE453_RS00825	COG5489	Protein of unknown function (DUF736)
CE453_RS00855	COG1192	Involved in chromosome partitioning
CE453_RS00870	COG2197	response regulator
CE453_RS00930	COG1126	abc transporter atp-binding protein
CE453_RS00935	COG0765	amino acid transport
CE453_RS00940	COG4597	amino acid ABC transporter
CE453_RS00945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE453_RS00955	COG0583	DNA-binding transcription factor activity
CE453_RS00965	COG2244	polysaccharide biosynthetic process
CE453_RS01010	COG0798	PFAM Bile acid sodium symporter
CE453_RS01080	COG0640	Transcriptional regulator
CE453_RS01085	COG0737	Belongs to the 5'-nucleotidase family
CE453_RS01090	COG4691	Plasmid stability protein
CE453_RS01115	COG1376	ErfK ybiS ycfS ynhG family protein
CE453_RS01115	COG1388	LysM domain
CE453_RS01125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CE453_RS01140	COG3258	Cytochrome c
CE453_RS01150	COG3453	Protein conserved in bacteria
CE453_RS01150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CE453_RS01155	COG2391	methyltransferase activity
CE453_RS01160	COG2391	methyltransferase activity
CE453_RS01175	COG2197	response regulator
CE453_RS01190	COG1192	Involved in chromosome partitioning
CE453_RS01200	COG1414	Transcriptional regulator
CE453_RS01215	COG0629	single-stranded DNA binding
CE453_RS01230	COG1475	DNA binding
CE453_RS01235	COG1192	Involved in chromosome partitioning
CE453_RS01290	COG5489	Protein of unknown function (DUF736)
CE453_RS01325	COG4227	nucleotidyltransferase activity
CE453_RS01345	COG4974	Belongs to the 'phage' integrase family
CE453_RS01385	COG1475	DNA binding
CE453_RS01410	COG3474	cytochrome
CE453_RS01525	COG3451	type IV secretory pathway VirB4
CE453_RS01560	COG3504	Conjugal transfer protein
CE453_RS01570	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
CE453_RS01580	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CE453_RS01580	COG1618	nucleotide phosphatase activity, acting on free nucleotides
CE453_RS01600	COG0243	molybdopterin cofactor binding
CE453_RS01640	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CE453_RS01650	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CE453_RS01675	COG1522	sequence-specific DNA binding
CE453_RS01690	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS01695	COG0625	glutathione transferase activity
CE453_RS01700	COG1053	succinate dehydrogenase
CE453_RS01705	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS01745	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CE453_RS01755	COG0179	Fumarylacetoacetate (FAA) hydrolase
CE453_RS01765	COG0514	ATP-dependent DNA helicase (RecQ)
CE453_RS01795	COG5642	Protein of unknown function (DUF2384)
CE453_RS01805	COG3002	Belongs to the UPF0753 family
CE453_RS01810	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CE453_RS01835	COG0133	tryptophan synthase activity
CE453_RS01840	COG3046	protein related to deoxyribodipyrimidine photolyase
CE453_RS01850	COG0415	Belongs to the DNA photolyase family
CE453_RS01865	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CE453_RS01880	COG1595	DNA-templated transcription, initiation
CE453_RS01905	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CE453_RS01910	COG3040	lipid binding
CE453_RS01935	COG5425	PFAM Usg family protein
CE453_RS01940	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CE453_RS01945	COG0459	protein refolding
CE453_RS01960	COG0326	Molecular chaperone. Has ATPase activity
CE453_RS01965	COG1802	Transcriptional regulator
CE453_RS01970	COG0402	S-adenosylhomocysteine deaminase activity
CE453_RS01985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CE453_RS01995	COG4608	Belongs to the ABC transporter superfamily
CE453_RS02000	COG0444	Belongs to the ABC transporter superfamily
CE453_RS02005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE453_RS02010	COG0601	transmembrane transport
CE453_RS02025	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CE453_RS02055	COG0071	Belongs to the small heat shock protein (HSP20) family
CE453_RS02075	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS02120	COG1012	belongs to the aldehyde dehydrogenase family
CE453_RS02125	COG1999	signal sequence binding
CE453_RS02135	COG0133	tryptophan synthase activity
CE453_RS02140	COG0135	phosphoribosylanthranilate isomerase activity
CE453_RS02150	COG1217	gtp-binding protein TYPA
CE453_RS02155	COG0667	Aldo Keto reductase
CE453_RS02165	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CE453_RS02165	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CE453_RS02185	COG0784	Response regulator, receiver
CE453_RS02205	COG0784	Response regulator, receiver
CE453_RS02235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CE453_RS02240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CE453_RS02250	COG2066	Belongs to the glutaminase family
CE453_RS02255	COG0717	Belongs to the dCTP deaminase family
CE453_RS02260	COG2967	ApaG domain
CE453_RS02275	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CE453_RS02280	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CE453_RS02290	COG0765	amino acid transport
CE453_RS02295	COG4597	amino acid ABC transporter
CE453_RS02300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE453_RS02305	COG0516	GMP reductase activity
CE453_RS02345	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS02360	COG0156	8-amino-7-oxononanoate synthase activity
CE453_RS02370	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CE453_RS02375	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CE453_RS02380	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CE453_RS02380	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CE453_RS02395	COG0779	Required for maturation of 30S ribosomal subunits
CE453_RS02405	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CE453_RS02410	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CE453_RS02415	COG1396	sequence-specific DNA binding
CE453_RS02420	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CE453_RS02425	COG1253	flavin adenine dinucleotide binding
CE453_RS02430	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CE453_RS02435	COG1702	phosphate starvation-inducible protein PhoH
CE453_RS02440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CE453_RS02450	COG0456	acetyltransferase
CE453_RS02450	COG0454	-acetyltransferase
CE453_RS02460	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CE453_RS02470	COG0180	Tryptophanyl-tRNA synthetase
CE453_RS02480	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CE453_RS02485	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CE453_RS02490	COG0840	transmembrane signaling receptor activity
CE453_RS02505	COG1733	regulation of RNA biosynthetic process
CE453_RS02510	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CE453_RS02515	COG1185	polyribonucleotide nucleotidyltransferase activity
CE453_RS02530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CE453_RS02555	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CE453_RS02560	COG1253	flavin adenine dinucleotide binding
CE453_RS02570	COG0237	dephospho-CoA kinase activity
CE453_RS02575	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CE453_RS02580	COG0424	maF-like protein
CE453_RS02585	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CE453_RS02590	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CE453_RS02595	COG1981	membrane
CE453_RS02600	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CE453_RS02605	COG1331	Highly conserved protein containing a thioredoxin domain
CE453_RS02610	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CE453_RS02615	COG0445	tRNA wobble uridine modification
CE453_RS02620	COG0357	Ribosomal RNA small subunit methyltransferase G
CE453_RS02645	COG0495	leucyl-tRNA aminoacylation
CE453_RS02650	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CE453_RS02665	COG0745	RESPONSE REGULATOR receiver
CE453_RS02700	COG0004	ammonium transporteR
CE453_RS02705	COG0347	Belongs to the P(II) protein family
CE453_RS02710	COG1946	Acyl-CoA thioesterase
CE453_RS02715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CE453_RS02720	COG2835	tetraacyldisaccharide 4'-kinase activity
CE453_RS02725	COG2902	Dehydrogenase
CE453_RS02745	COG0670	Belongs to the BI1 family
CE453_RS02755	COG4181	ATPase activity
CE453_RS02765	COG0667	Aldo Keto reductase
CE453_RS02775	COG2154	pterin-4-alpha-carbinolamine dehydratase
CE453_RS02780	COG0564	pseudouridine synthase activity
CE453_RS02785	COG0552	protein localization to endoplasmic reticulum
CE453_RS02790	COG2917	probably involved in intracellular septation
CE453_RS02795	COG5642	Protein of unknown function (DUF2384)
CE453_RS02820	COG3321	synthase
CE453_RS02820	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS02820	COG0604	alcohol dehydrogenase
CE453_RS02830	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CE453_RS02840	COG0671	phosphoesterase, PA-phosphatase related
CE453_RS02850	COG1704	LemA family
CE453_RS02855	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CE453_RS02870	COG1560	Kdo2-lipid A biosynthetic process
CE453_RS02875	COG0604	alcohol dehydrogenase
CE453_RS02875	COG3321	synthase
CE453_RS02885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CE453_RS02890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CE453_RS02895	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CE453_RS02900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CE453_RS02905	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CE453_RS02910	COG4133	protoheme IX ABC transporter activity
CE453_RS02915	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CE453_RS02925	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CE453_RS02935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CE453_RS02940	COG0047	phosphoribosylformylglycinamidine synthase activity
CE453_RS02945	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CE453_RS02955	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CE453_RS02975	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CE453_RS02985	COG0739	heme binding
CE453_RS03020	COG3453	Protein conserved in bacteria
CE453_RS03020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CE453_RS03040	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CE453_RS03055	COG0138	bifunctional purine biosynthesis protein purh
CE453_RS03065	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CE453_RS03065	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CE453_RS03070	COG0501	Belongs to the peptidase M48B family
CE453_RS03080	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CE453_RS03090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CE453_RS03095	COG1376	ErfK ybiS ycfS ynhG family protein
CE453_RS03100	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CE453_RS03105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CE453_RS03110	COG4558	Periplasmic binding protein
CE453_RS03135	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CE453_RS03140	COG2301	Belongs to the HpcH HpaI aldolase family
CE453_RS03150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CE453_RS03155	COG2030	dehydratase
CE453_RS03165	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CE453_RS03185	COG0519	Catalyzes the synthesis of GMP from XMP
CE453_RS03185	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CE453_RS03195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CE453_RS03230	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CE453_RS03235	COG3616	Alanine racemase, N-terminal domain
CE453_RS03240	COG1132	(ABC) transporter
CE453_RS03265	COG1172	Belongs to the binding-protein-dependent transport system permease family
CE453_RS03270	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS03275	COG1070	Carbohydrate kinase
CE453_RS03280	COG0673	inositol 2-dehydrogenase activity
CE453_RS03315	COG4172	Belongs to the ABC transporter superfamily
CE453_RS03320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE453_RS03360	COG2309	aminopeptidase activity
CE453_RS03375	COG0628	permease
CE453_RS03390	COG3118	belongs to the thioredoxin family
CE453_RS03395	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CE453_RS03405	COG5310	Homospermidine synthase
CE453_RS03425	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CE453_RS03440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CE453_RS03450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CE453_RS03455	COG1585	Membrane protein implicated in regulation of membrane protease activity
CE453_RS03460	COG0330	HflC and HflK could
CE453_RS03470	COG0653	protein targeting
CE453_RS03480	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CE453_RS03485	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CE453_RS03500	COG0494	nUDIX hydrolase
CE453_RS03510	COG3214	Protein conserved in bacteria
CE453_RS03520	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CE453_RS03520	COG3264	Mechanosensitive ion channel
CE453_RS03535	COG0456	acetyltransferase
CE453_RS03535	COG1214	PFAM Peptidase M22, glycoprotease
CE453_RS03545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CE453_RS03555	COG0825	malonyl-CoA metabolic process
CE453_RS03560	COG3034	peptidoglycan biosynthetic process
CE453_RS03570	COG1846	Transcriptional regulator
CE453_RS03575	COG2267	carboxylic ester hydrolase activity
CE453_RS03580	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CE453_RS03585	COG0737	Belongs to the 5'-nucleotidase family
CE453_RS03590	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CE453_RS03600	COG2738	Putative neutral zinc metallopeptidase
CE453_RS03630	COG1022	Amp-dependent synthetase and ligase
CE453_RS03685	COG0154	amidase activity
CE453_RS03710	COG2358	TRAP transporter, solute receptor (TAXI family
CE453_RS03715	COG1121	(ABC) transporter
CE453_RS03725	COG0803	Belongs to the bacterial solute-binding protein 9 family
CE453_RS03750	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CE453_RS03755	COG1132	(ABC) transporter
CE453_RS03765	COG0387	Pfam Sodium calcium exchanger
CE453_RS03775	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CE453_RS03780	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CE453_RS03790	COG4974	Belongs to the 'phage' integrase family
CE453_RS03795	COG0288	reversible hydration of carbon dioxide
CE453_RS03800	COG1872	DUF167
CE453_RS03810	COG0747	negative chemotaxis
CE453_RS03815	COG0405	Gamma-glutamyltransferase
CE453_RS03870	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CE453_RS03935	COG5654	RES domain protein
CE453_RS03940	COG5642	Protein of unknown function (DUF2384)
CE453_RS03985	COG2161	toxin-antitoxin pair type II binding
CE453_RS03990	COG4115	mRNA cleavage
CE453_RS04050	COG0582	viral genome integration into host DNA
CE453_RS04145	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CE453_RS04180	COG4948	Mandelate Racemase Muconate Lactonizing
CE453_RS04185	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CE453_RS04200	COG0601	transmembrane transport
CE453_RS04205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE453_RS04210	COG2186	Transcriptional regulator
CE453_RS04215	COG0028	Belongs to the TPP enzyme family
CE453_RS04235	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CE453_RS04255	COG0559	Belongs to the binding-protein-dependent transport system permease family
CE453_RS04275	COG0829	nickel cation binding
CE453_RS04280	COG0831	urea catabolic process
CE453_RS04290	COG0832	Belongs to the urease beta subunit family
CE453_RS04295	COG0804	urea catabolic process
CE453_RS04300	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CE453_RS04305	COG0830	nickel cation binding
CE453_RS04310	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CE453_RS04325	COG0640	Transcriptional regulator
CE453_RS04345	COG2391	methyltransferase activity
CE453_RS04360	COG2010	Cytochrome c
CE453_RS04365	COG3258	Cytochrome c
CE453_RS04380	COG0737	Belongs to the 5'-nucleotidase family
CE453_RS04385	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CE453_RS04405	COG0446	pyridine nucleotide-disulphide oxidoreductase
CE453_RS04415	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CE453_RS04420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CE453_RS04425	COG3842	ATPase activity
CE453_RS04430	COG0165	Argininosuccinate lyase
CE453_RS04435	COG0395	ABC-type sugar transport system, permease component
CE453_RS04490	COG1126	abc transporter atp-binding protein
CE453_RS04510	COG0683	leucine binding
CE453_RS04525	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CE453_RS04535	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CE453_RS04540	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS04550	COG0601	transmembrane transport
CE453_RS04555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE453_RS04590	COG4948	Mandelate Racemase Muconate Lactonizing
CE453_RS04595	COG1175	transmembrane transport
CE453_RS04620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CE453_RS04635	COG0601	transmembrane transport
CE453_RS04640	COG0747	negative chemotaxis
CE453_RS04650	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CE453_RS04660	COG1363	Peptidase, m42
CE453_RS04670	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CE453_RS04670	COG2169	Transcriptional regulator
CE453_RS04680	COG2169	Transcriptional regulator
CE453_RS04680	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CE453_RS04690	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CE453_RS04690	COG2169	Transcriptional regulator
CE453_RS04705	COG2081	HI0933 family
CE453_RS04735	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS04740	COG4948	Mandelate Racemase Muconate Lactonizing
CE453_RS04750	COG0395	ABC-type sugar transport system, permease component
CE453_RS04770	COG0596	Alpha beta hydrolase
CE453_RS04775	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS04785	COG1414	Transcriptional regulator
CE453_RS04795	COG3485	protocatechuate 3,4-dioxygenase
CE453_RS04815	COG4172	Belongs to the ABC transporter superfamily
CE453_RS04820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE453_RS04835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CE453_RS04840	COG2188	Transcriptional regulator
CE453_RS04860	COG0765	amino acid transport
CE453_RS04870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CE453_RS04875	COG1012	belongs to the aldehyde dehydrogenase family
CE453_RS04880	COG0446	pyridine nucleotide-disulphide oxidoreductase
CE453_RS04890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CE453_RS04900	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CE453_RS04900	COG0515	serine threonine protein kinase
CE453_RS04930	COG0140	phosphoribosyl-ATP diphosphatase activity
CE453_RS04940	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CE453_RS04950	COG0469	pyruvate kinase activity
CE453_RS04965	COG3750	Belongs to the UPF0335 family
CE453_RS04970	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CE453_RS04985	COG3108	Peptidase M15
CE453_RS04995	COG2204	response regulator
CE453_RS05010	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CE453_RS05010	COG0517	IMP dehydrogenase activity
CE453_RS05015	COG0789	Transcriptional regulator
CE453_RS05025	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CE453_RS05060	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CE453_RS05070	COG0494	nUDIX hydrolase
CE453_RS05080	COG0793	Belongs to the peptidase S41A family
CE453_RS05085	COG1388	LysM domain
CE453_RS05085	COG4942	peptidase
CE453_RS05090	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CE453_RS05095	COG0799	negative regulation of ribosome biogenesis
CE453_RS05100	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CE453_RS05105	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CE453_RS05110	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CE453_RS05115	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CE453_RS05125	COG1595	DNA-templated transcription, initiation
CE453_RS05150	COG0840	transmembrane signaling receptor activity
CE453_RS05165	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CE453_RS05170	COG3454	Phosphonate metabolism
CE453_RS05175	COG4778	phosphonate C-P lyase system protein PhnL
CE453_RS05180	COG4107	phosphonate C-P lyase system protein PhnK
CE453_RS05185	COG3627	carbon phosphorus lyase activity
CE453_RS05190	COG3626	phosphonate metabolism
CE453_RS05195	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
CE453_RS05200	COG3624	Phosphonate C-P lyase system protein PhnG
CE453_RS05205	COG2188	Transcriptional regulator
CE453_RS05210	COG3639	organic phosphonate transmembrane transporter activity
CE453_RS05215	COG3639	organic phosphonate transmembrane transporter activity
CE453_RS05225	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CE453_RS05230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CE453_RS05235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CE453_RS05240	COG4953	penicillin-binding protein 1C
CE453_RS05270	COG1024	Enoyl-CoA hydratase
CE453_RS05275	COG2354	Protein conserved in bacteria
CE453_RS05285	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CE453_RS05290	COG1473	amidohydrolase
CE453_RS05295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE453_RS05300	COG0246	Mannitol dehydrogenase
CE453_RS05310	COG0747	negative chemotaxis
CE453_RS05320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE453_RS05330	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS05340	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CE453_RS05350	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CE453_RS05355	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CE453_RS05360	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CE453_RS05365	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CE453_RS05375	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CE453_RS05385	COG0640	Transcriptional regulator
CE453_RS05390	COG1902	pentaerythritol trinitrate reductase activity
CE453_RS05405	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CE453_RS05410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CE453_RS05415	COG0523	cobalamin synthesis protein
CE453_RS05425	COG1686	Belongs to the peptidase S11 family
CE453_RS05435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CE453_RS05460	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CE453_RS05460	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CE453_RS05480	COG1040	competence protein
CE453_RS05485	COG1902	pentaerythritol trinitrate reductase activity
CE453_RS05495	COG3618	amidohydrolase
CE453_RS05500	COG2271	Major facilitator Superfamily
CE453_RS05545	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CE453_RS05550	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CE453_RS05555	COG0583	DNA-binding transcription factor activity
CE453_RS05570	COG0747	negative chemotaxis
CE453_RS05580	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS05595	COG4948	Mandelate Racemase Muconate Lactonizing
CE453_RS05620	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CE453_RS05625	COG1414	Transcriptional regulator
CE453_RS05630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CE453_RS05635	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CE453_RS05650	COG0483	inositol monophosphate 1-phosphatase activity
CE453_RS05675	COG4598	ABC transporter
CE453_RS05680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CE453_RS05690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CE453_RS05700	COG0557	exoribonuclease II activity
CE453_RS05715	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CE453_RS05720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CE453_RS05730	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CE453_RS05735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CE453_RS05750	COG0840	transmembrane signaling receptor activity
CE453_RS05775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CE453_RS05780	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CE453_RS05810	COG1126	abc transporter atp-binding protein
CE453_RS05815	COG0765	amino acid transport
CE453_RS05820	COG0765	amino acid transport
CE453_RS05840	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CE453_RS05855	COG0601	transmembrane transport
CE453_RS05860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE453_RS05865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CE453_RS05870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CE453_RS05880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CE453_RS05890	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CE453_RS05900	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CE453_RS05900	COG2010	Cytochrome c
CE453_RS05905	COG0402	S-adenosylhomocysteine deaminase activity
CE453_RS05915	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CE453_RS05915	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CE453_RS05925	COG1879	ABC-type sugar transport system periplasmic component
CE453_RS05930	COG1172	Belongs to the binding-protein-dependent transport system permease family
CE453_RS05950	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CE453_RS05955	COG0745	RESPONSE REGULATOR receiver
CE453_RS05960	COG2205	protein histidine kinase activity
CE453_RS05975	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CE453_RS06025	COG4191	Histidine kinase
CE453_RS06030	COG2204	response regulator
CE453_RS06045	COG1846	Transcriptional regulator
CE453_RS06065	COG1216	Glycosyl transferase, family 2
CE453_RS06065	COG0438	transferase activity, transferring glycosyl groups
CE453_RS06070	COG2226	methyltransferase
CE453_RS06120	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CE453_RS06125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CE453_RS06170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE453_RS06175	COG0601	transmembrane transport
CE453_RS06180	COG0747	negative chemotaxis
CE453_RS06190	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS06205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CE453_RS06240	COG1177	transmembrane transport
CE453_RS06245	COG3842	ATPase activity
CE453_RS06255	COG4608	Belongs to the ABC transporter superfamily
CE453_RS06260	COG0444	Belongs to the ABC transporter superfamily
CE453_RS06265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE453_RS06270	COG0601	transmembrane transport
CE453_RS06280	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS06295	COG0726	polysaccharide deacetylase
CE453_RS06300	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS06310	COG2814	Major facilitator Superfamily
CE453_RS06320	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CE453_RS06325	COG2252	PERMEase
CE453_RS06340	COG4948	Mandelate Racemase Muconate Lactonizing
CE453_RS06345	COG1802	Transcriptional regulator
CE453_RS06355	COG1175	transmembrane transport
CE453_RS06360	COG0395	ABC-type sugar transport system, permease component
CE453_RS06385	COG1596	polysaccharide export
CE453_RS06420	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CE453_RS06425	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CE453_RS06430	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CE453_RS06440	COG1215	transferase activity, transferring glycosyl groups
CE453_RS06450	COG3944	biosynthesis protein
CE453_RS06460	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CE453_RS06475	COG1215	transferase activity, transferring glycosyl groups
CE453_RS06480	COG2197	response regulator
CE453_RS06485	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CE453_RS06490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE453_RS06495	COG4597	amino acid ABC transporter
CE453_RS06500	COG0765	amino acid transport
CE453_RS06515	COG2894	cell division
CE453_RS06520	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CE453_RS06535	COG0166	Belongs to the GPI family
CE453_RS06540	COG1250	3-hydroxyacyl-CoA dehydrogenase
CE453_RS06540	COG1024	Enoyl-CoA hydratase
CE453_RS06545	COG2814	Major facilitator Superfamily
CE453_RS06550	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CE453_RS06565	COG0129	dihydroxy-acid dehydratase activity
CE453_RS06570	COG4988	ABC transporter
CE453_RS06580	COG4988	ABC transporter
CE453_RS06585	COG1271	oxidase subunit
CE453_RS06590	COG1294	oxidase, subunit
CE453_RS06610	COG0583	DNA-binding transcription factor activity
CE453_RS06620	COG1473	amidohydrolase
CE453_RS06650	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CE453_RS06655	COG0697	spore germination
CE453_RS06660	COG1309	transcriptional regulator
CE453_RS06675	COG0735	belongs to the Fur family
CE453_RS06690	COG1278	Cold shock
CE453_RS06710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CE453_RS06725	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CE453_RS06730	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CE453_RS06745	COG0564	pseudouridine synthase activity
CE453_RS06750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CE453_RS06785	COG2884	Cell division ATP-binding protein ftsE
CE453_RS06800	COG2204	response regulator
CE453_RS06810	COG3179	chitinase
CE453_RS06820	COG1522	sequence-specific DNA binding
CE453_RS06830	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CE453_RS06835	COG0842	Transport permease protein
CE453_RS06840	COG1131	(ABC) transporter
CE453_RS06855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CE453_RS06870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CE453_RS06880	COG0546	phosphoglycolate phosphatase activity
CE453_RS06880	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CE453_RS06895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CE453_RS06900	COG2186	Transcriptional regulator
CE453_RS06905	COG3842	ATPase activity
CE453_RS06915	COG1175	transmembrane transport
CE453_RS06920	COG0395	ABC-type sugar transport system, permease component
CE453_RS06925	COG2084	Dehydrogenase
CE453_RS06930	COG1609	Transcriptional regulator
CE453_RS06965	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CE453_RS06980	COG1250	3-hydroxyacyl-CoA dehydrogenase
CE453_RS06985	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CE453_RS06990	COG2086	electron transfer activity
CE453_RS07025	COG0438	transferase activity, transferring glycosyl groups
CE453_RS07030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE453_RS07035	COG0601	transmembrane transport
CE453_RS07040	COG0747	negative chemotaxis
CE453_RS07055	COG1132	(ABC) transporter
CE453_RS07080	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CE453_RS07110	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CE453_RS07130	COG0129	dihydroxy-acid dehydratase activity
CE453_RS07155	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS07160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CE453_RS07170	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CE453_RS07195	COG4957	zinc ion binding
CE453_RS07220	COG3685	Protein conserved in bacteria
CE453_RS07265	COG0582	viral genome integration into host DNA
CE453_RS07280	COG0653	protein targeting
CE453_RS07290	COG0583	DNA-binding transcription factor activity
CE453_RS07305	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CE453_RS07315	COG0683	leucine binding
CE453_RS07340	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CE453_RS07380	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CE453_RS07415	COG1917	Cupin 2, conserved barrel domain protein
CE453_RS07420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CE453_RS07425	COG0583	DNA-binding transcription factor activity
CE453_RS07455	COG0395	ABC-type sugar transport system, permease component
CE453_RS07505	COG2267	carboxylic ester hydrolase activity
CE453_RS07510	COG0071	Belongs to the small heat shock protein (HSP20) family
CE453_RS07525	COG0069	glutamate synthase activity
CE453_RS07525	COG0070	glutamate synthase
CE453_RS07525	COG0067	glutamate synthase
CE453_RS07535	COG0488	(ABC) transporter
CE453_RS07555	COG2951	lytic endotransglycosylase activity
CE453_RS07560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CE453_RS07570	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CE453_RS07575	COG2226	methyltransferase
CE453_RS07585	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CE453_RS07600	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CE453_RS07610	COG3813	Protein conserved in bacteria
CE453_RS07615	COG2192	nodulation
CE453_RS07625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CE453_RS07630	COG0165	Argininosuccinate lyase
CE453_RS07640	COG0019	diaminopimelate decarboxylase activity
CE453_RS07655	COG2223	nitrite transmembrane transporter activity
CE453_RS07670	COG0183	Belongs to the thiolase family
CE453_RS07675	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
CE453_RS07680	COG5001	Diguanylate cyclase
CE453_RS07680	COG5002	protein histidine kinase activity
CE453_RS07690	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CE453_RS07695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CE453_RS07700	COG0142	geranyltranstransferase activity
CE453_RS07710	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CE453_RS07715	COG1473	amidohydrolase
CE453_RS07735	COG1971	Probably functions as a manganese efflux pump
CE453_RS07760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CE453_RS07765	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CE453_RS07790	COG1653	transport
CE453_RS07795	COG1175	transmembrane transport
CE453_RS07800	COG3833	ABC-type maltose transport systems, permease component
CE453_RS07805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CE453_RS07835	COG2326	polyphosphate kinase activity
CE453_RS07840	COG5002	protein histidine kinase activity
CE453_RS07850	COG0573	inorganic phosphate transmembrane transporter activity
CE453_RS07855	COG0581	inorganic phosphate transmembrane transporter activity
CE453_RS07860	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CE453_RS07865	COG0704	Plays a role in the regulation of phosphate uptake
CE453_RS07870	COG0745	RESPONSE REGULATOR receiver
CE453_RS07890	COG0165	Argininosuccinate lyase
CE453_RS07905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE453_RS07910	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CE453_RS07920	COG0039	L-malate dehydrogenase activity
CE453_RS07930	COG0045	succinate-CoA ligase (ADP-forming) activity
CE453_RS07935	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CE453_RS07940	COG0567	Dehydrogenase, E1 component
CE453_RS07945	COG0508	dehydrogenase complex catalyzes the overall conversion of
CE453_RS07950	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS07960	COG1620	l-lactate permease
CE453_RS07965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CE453_RS07975	COG0402	S-adenosylhomocysteine deaminase activity
CE453_RS07985	COG2249	NAD(P)H dehydrogenase (quinone) activity
CE453_RS08000	COG3158	transport of potassium into the cell
CE453_RS08005	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CE453_RS08010	COG0735	belongs to the Fur family
CE453_RS08015	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS08030	COG4651	solute:proton antiporter activity
CE453_RS08030	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CE453_RS08060	COG3718	enzyme involved in inositol metabolism
CE453_RS08065	COG1082	Xylose isomerase domain protein TIM barrel
CE453_RS08070	COG3962	Belongs to the TPP enzyme family
CE453_RS08080	COG1737	Transcriptional regulator
CE453_RS08085	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS08090	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CE453_RS08115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CE453_RS08125	COG2195	Cleaves the N-terminal amino acid of tripeptides
CE453_RS08135	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CE453_RS08140	COG1288	antiporter activity
CE453_RS08155	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CE453_RS08160	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CE453_RS08190	COG0318	PFAM AMP-dependent synthetase and ligase
CE453_RS08205	COG1234	tRNA 3'-trailer cleavage
CE453_RS08215	COG0604	alcohol dehydrogenase
CE453_RS08215	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS08215	COG3321	synthase
CE453_RS08230	COG0254	rRNA binding
CE453_RS08235	COG1132	(ABC) transporter
CE453_RS08255	COG0483	inositol monophosphate 1-phosphatase activity
CE453_RS08270	COG3135	benzoate transporter
CE453_RS08280	COG0126	phosphoglycerate kinase activity
CE453_RS08310	COG2885	chlorophyll binding
CE453_RS08315	COG0640	Transcriptional regulator
CE453_RS08330	COG0235	Class ii aldolase
CE453_RS08345	COG0848	biopolymer transport protein
CE453_RS08360	COG1309	transcriptional regulator
CE453_RS08365	COG0824	Thioesterase
CE453_RS08375	COG2255	four-way junction helicase activity
CE453_RS08380	COG0456	acetyltransferase
CE453_RS08385	COG0632	four-way junction helicase activity
CE453_RS08390	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CE453_RS08400	COG0217	transcriptional regulatory protein
CE453_RS08405	COG1692	metallophosphoesterase
CE453_RS08425	COG0037	tRNA processing
CE453_RS08430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CE453_RS08435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CE453_RS08440	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS08445	COG1063	alcohol dehydrogenase
CE453_RS08450	COG3454	Phosphonate metabolism
CE453_RS08455	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CE453_RS08460	COG0625	glutathione transferase activity
CE453_RS08470	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CE453_RS08485	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CE453_RS08490	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CE453_RS08520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CE453_RS08525	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CE453_RS08535	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CE453_RS08540	COG2818	Glycosylase
CE453_RS08550	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CE453_RS08560	COG3795	YCII-related domain
CE453_RS08565	COG3795	YCII-related domain
CE453_RS08570	COG3795	YCII-related domain
CE453_RS08575	COG4941	Belongs to the sigma-70 factor family
CE453_RS08590	COG0494	nUDIX hydrolase
CE453_RS08595	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS08600	COG0259	pyridoxamine-phosphate oxidase activity
CE453_RS08610	COG0484	heat shock protein binding
CE453_RS08615	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CE453_RS08630	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CE453_RS08635	COG0406	alpha-ribazole phosphatase activity
CE453_RS08640	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CE453_RS08645	COG1187	pseudouridine synthase activity
CE453_RS08655	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CE453_RS08655	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CE453_RS08660	COG0123	including yeast histone deacetylase and acetoin utilization protein
CE453_RS08665	COG1376	ErfK ybiS ycfS ynhG family protein
CE453_RS08675	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CE453_RS08680	COG0154	amidase activity
CE453_RS08690	COG0318	PFAM AMP-dependent synthetase and ligase
CE453_RS08700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CE453_RS08705	COG1268	BioY protein
CE453_RS08775	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CE453_RS08795	COG1250	3-hydroxyacyl-CoA dehydrogenase
CE453_RS08810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CE453_RS08815	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CE453_RS08825	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CE453_RS08825	COG0662	Cupin 2, conserved barrel domain protein
CE453_RS08830	COG1088	dTDP-glucose 4,6-dehydratase activity
CE453_RS08835	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CE453_RS08840	COG1091	dTDP-4-dehydrorhamnose reductase activity
CE453_RS08845	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CE453_RS08865	COG0489	protein tyrosine kinase activity
CE453_RS08865	COG3206	protein involved in exopolysaccharide biosynthesis
CE453_RS08880	COG0438	transferase activity, transferring glycosyl groups
CE453_RS08890	COG0438	transferase activity, transferring glycosyl groups
CE453_RS08905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CE453_RS08920	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CE453_RS08945	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
CE453_RS08995	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CE453_RS09000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CE453_RS09010	COG4206	TonB-dependent receptor
CE453_RS09015	COG2855	membrane
CE453_RS09020	COG1032	radical SAM domain protein
CE453_RS09030	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CE453_RS09035	COG1278	Cold shock
CE453_RS09040	COG1272	protein, Hemolysin III
CE453_RS09055	COG0482	sulfurtransferase activity
CE453_RS09075	COG1766	The M ring may be actively involved in energy transduction
CE453_RS09080	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CE453_RS09090	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CE453_RS09095	COG2204	response regulator
CE453_RS09105	COG2271	Major facilitator Superfamily
CE453_RS09110	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CE453_RS09115	COG0697	spore germination
CE453_RS09120	COG0392	lysyltransferase activity
CE453_RS09160	COG0745	RESPONSE REGULATOR receiver
CE453_RS09165	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CE453_RS09170	COG2201	protein-glutamate methylesterase activity
CE453_RS09175	COG2201	protein-glutamate methylesterase activity
CE453_RS09185	COG2198	Histidine kinase
CE453_RS09185	COG0784	Response regulator, receiver
CE453_RS09185	COG0643	Histidine kinase
CE453_RS09240	COG0438	transferase activity, transferring glycosyl groups
CE453_RS09250	COG1063	alcohol dehydrogenase
CE453_RS09260	COG3622	Belongs to the hyi family
CE453_RS09265	COG0837	glucose binding
CE453_RS09270	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CE453_RS09280	COG0488	(ABC) transporter
CE453_RS09305	COG0165	Argininosuccinate lyase
CE453_RS09310	COG0456	acetyltransferase
CE453_RS09330	COG0714	Associated with various cellular activities
CE453_RS09350	COG0617	tRNA 3'-terminal CCA addition
CE453_RS09355	COG0408	coproporphyrinogen oxidase activity
CE453_RS09360	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CE453_RS09365	COG1132	(ABC) transporter
CE453_RS09370	COG0723	plastoquinol--plastocyanin reductase activity
CE453_RS09375	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CE453_RS09375	COG2857	Cytochrome c1
CE453_RS09380	COG2857	Cytochrome c1
CE453_RS09380	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CE453_RS09385	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CE453_RS09390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CE453_RS09395	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CE453_RS09400	COG0235	Class ii aldolase
CE453_RS09410	COG2244	polysaccharide biosynthetic process
CE453_RS09415	COG1216	Glycosyl transferase, family 2
CE453_RS09420	COG1215	transferase activity, transferring glycosyl groups
CE453_RS09425	COG2030	dehydratase
CE453_RS09430	COG0012	GTP binding
CE453_RS09440	COG0193	aminoacyl-tRNA hydrolase activity
CE453_RS09445	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CE453_RS09460	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CE453_RS09465	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CE453_RS09495	COG0840	transmembrane signaling receptor activity
CE453_RS09500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CE453_RS09510	COG0625	glutathione transferase activity
CE453_RS09515	COG0583	DNA-binding transcription factor activity
CE453_RS09520	COG2205	protein histidine kinase activity
CE453_RS09525	COG0745	RESPONSE REGULATOR receiver
CE453_RS09530	COG1846	Transcriptional regulator
CE453_RS09535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CE453_RS09545	COG0314	molybdopterin synthase activity
CE453_RS09555	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CE453_RS09560	COG0322	excinuclease ABC activity
CE453_RS09570	COG2130	NADP-dependent
CE453_RS09575	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CE453_RS09595	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS09600	COG0463	Glycosyl transferase, family 2
CE453_RS09605	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CE453_RS09610	COG0625	glutathione transferase activity
CE453_RS09615	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CE453_RS09635	COG0697	spore germination
CE453_RS09655	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CE453_RS09680	COG0066	3-isopropylmalate dehydratase activity
CE453_RS09695	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CE453_RS09715	COG0335	large ribosomal subunit rRNA binding
CE453_RS09720	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS09745	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CE453_RS09750	COG0318	PFAM AMP-dependent synthetase and ligase
CE453_RS09760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CE453_RS09765	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CE453_RS09780	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CE453_RS09785	COG1280	lysine exporter protein (LysE YggA)
CE453_RS09800	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CE453_RS09805	COG0228	four-way junction DNA binding
CE453_RS09810	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CE453_RS09820	COG0336	Belongs to the RNA methyltransferase TrmD family
CE453_RS09830	COG0436	Aminotransferase
CE453_RS09835	COG1671	Belongs to the UPF0178 family
CE453_RS09850	COG2133	pyrroloquinoline quinone binding
CE453_RS09865	COG2951	lytic endotransglycosylase activity
CE453_RS09875	COG0473	3-isopropylmalate dehydrogenase activity
CE453_RS09895	COG0583	DNA-binding transcription factor activity
CE453_RS09900	COG0492	ferredoxin-NADP+ reductase activity
CE453_RS09910	COG1522	sequence-specific DNA binding
CE453_RS09915	COG0148	phosphopyruvate hydratase activity
CE453_RS09920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CE453_RS09925	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CE453_RS09930	COG2814	Major facilitator Superfamily
CE453_RS09935	COG0640	Transcriptional regulator
CE453_RS09970	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CE453_RS09975	COG0697	spore germination
CE453_RS10000	COG0505	Belongs to the CarA family
CE453_RS10015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CE453_RS10025	COG1280	lysine exporter protein (LysE YggA)
CE453_RS10030	COG0432	Pfam Uncharacterised protein family UPF0047
CE453_RS10050	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CE453_RS10065	COG1607	acyl-coa hydrolase
CE453_RS10070	COG0840	transmembrane signaling receptor activity
CE453_RS10115	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CE453_RS10145	COG2925	Exonuclease
CE453_RS10165	COG1482	cell wall glycoprotein biosynthetic process
CE453_RS10175	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
CE453_RS10215	COG1272	protein, Hemolysin III
CE453_RS10230	COG1012	belongs to the aldehyde dehydrogenase family
CE453_RS10235	COG1764	response to oxidative stress
CE453_RS10240	COG0596	Alpha beta hydrolase
CE453_RS10250	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS10270	COG2205	protein histidine kinase activity
CE453_RS10275	COG0596	Alpha beta hydrolase
CE453_RS10285	COG0488	(ABC) transporter
CE453_RS10355	COG2267	carboxylic ester hydrolase activity
CE453_RS10375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CE453_RS10390	COG4191	Histidine kinase
CE453_RS10395	COG4566	intracellular signal transduction
CE453_RS10400	COG4566	intracellular signal transduction
CE453_RS10405	COG4566	intracellular signal transduction
CE453_RS10415	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS10420	COG0583	DNA-binding transcription factor activity
CE453_RS10460	COG0484	heat shock protein binding
CE453_RS10485	COG2837	iron assimilation
CE453_RS10505	COG1252	NADH dehydrogenase
CE453_RS10520	COG3246	L-lysine catabolic process to acetate
CE453_RS10525	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CE453_RS10540	COG1136	(ABC) transporter
CE453_RS10550	COG1785	Belongs to the alkaline phosphatase family
CE453_RS10555	COG2223	nitrite transmembrane transporter activity
CE453_RS10565	COG0840	transmembrane signaling receptor activity
CE453_RS10580	COG0745	RESPONSE REGULATOR receiver
CE453_RS10585	COG2198	Histidine kinase
CE453_RS10585	COG0643	Histidine kinase
CE453_RS10590	COG0835	chemotaxis
CE453_RS10595	COG0840	transmembrane signaling receptor activity
CE453_RS10600	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CE453_RS10605	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CE453_RS10610	COG2201	protein-glutamate methylesterase activity
CE453_RS10620	COG0386	Belongs to the glutathione peroxidase family
CE453_RS10625	COG0521	Mo-molybdopterin cofactor biosynthetic process
CE453_RS10640	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CE453_RS10650	COG0667	Aldo Keto reductase
CE453_RS10660	COG1309	transcriptional regulator
CE453_RS10665	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS10670	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CE453_RS10675	COG0488	(ABC) transporter
CE453_RS10705	COG1278	Cold shock
CE453_RS10725	COG2824	Alkylphosphonate utilization operon protein PhnA
CE453_RS10730	COG0456	acetyltransferase
CE453_RS10740	COG3023	N-Acetylmuramoyl-L-alanine amidase
CE453_RS10745	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CE453_RS10760	COG1764	response to oxidative stress
CE453_RS10765	COG1846	Transcriptional regulator
CE453_RS10770	COG2001	Belongs to the MraZ family
CE453_RS10790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CE453_RS10800	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CE453_RS10825	COG1309	transcriptional regulator
CE453_RS10835	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CE453_RS10840	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CE453_RS10845	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CE453_RS10850	COG0697	spore germination
CE453_RS10860	COG1181	Belongs to the D-alanine--D-alanine ligase family
CE453_RS10865	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CE453_RS10870	COG0849	cell division
CE453_RS10875	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CE453_RS10885	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CE453_RS10890	COG0497	DNA recombination
CE453_RS10895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CE453_RS10910	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CE453_RS10940	COG0006	proline dipeptidase activity
CE453_RS10950	COG2264	protein methyltransferase activity
CE453_RS10955	COG3706	GGDEF domain
CE453_RS10960	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CE453_RS10965	COG1733	regulation of RNA biosynthetic process
CE453_RS10980	COG0210	DNA helicase
CE453_RS10985	COG1960	acyl-CoA dehydrogenase activity
CE453_RS10990	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CE453_RS11005	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CE453_RS11015	COG0277	FAD linked oxidase domain protein
CE453_RS11035	COG0114	fumarate hydratase activity
CE453_RS11060	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CE453_RS11070	COG0318	PFAM AMP-dependent synthetase and ligase
CE453_RS11085	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CE453_RS11090	COG1802	Transcriptional regulator
CE453_RS11095	COG1968	undecaprenyl-diphosphatase activity
CE453_RS11105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CE453_RS11120	COG0583	DNA-binding transcription factor activity
CE453_RS11135	COG0330	HflC and HflK could
CE453_RS11140	COG0330	HflC and HflK could
CE453_RS11160	COG3830	Belongs to the UPF0237 family
CE453_RS11160	COG0560	Phosphoserine phosphatase
CE453_RS11165	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CE453_RS11170	COG3706	GGDEF domain
CE453_RS11175	COG0028	Belongs to the TPP enzyme family
CE453_RS11180	COG1794	racemase activity, acting on amino acids and derivatives
CE453_RS11185	COG0625	glutathione transferase activity
CE453_RS11190	COG0440	acetolactate synthase activity
CE453_RS11205	COG1309	transcriptional regulator
CE453_RS11210	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CE453_RS11235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CE453_RS11240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CE453_RS11250	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CE453_RS11260	COG0384	phenazine biosynthesis protein PhzF
CE453_RS11270	COG0339	signal peptide processing
CE453_RS11280	COG0659	secondary active sulfate transmembrane transporter activity
CE453_RS11295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CE453_RS11300	COG2233	PERMEase
CE453_RS11315	COG1285	pathogenesis
CE453_RS11360	COG0492	ferredoxin-NADP+ reductase activity
CE453_RS11370	COG1652	LysM domain
CE453_RS11375	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CE453_RS11390	COG3909	cytochrome
CE453_RS11395	COG2010	Cytochrome c
CE453_RS11415	COG1396	sequence-specific DNA binding
CE453_RS11420	COG0697	spore germination
CE453_RS11425	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS11435	COG0438	transferase activity, transferring glycosyl groups
CE453_RS11445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CE453_RS11470	COG3655	Transcriptional regulator
CE453_RS11480	COG3106	COG3106 Predicted ATPase
CE453_RS11485	COG3768	UPF0283 membrane protein
CE453_RS11510	COG5443	negative regulation of bacterial-type flagellum assembly
CE453_RS11540	COG1706	bacterial-type flagellum-dependent cell motility
CE453_RS11555	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS11565	COG0538	isocitrate dehydrogenase activity
CE453_RS11580	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CE453_RS11585	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CE453_RS11590	COG0477	Major facilitator Superfamily
CE453_RS11600	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CE453_RS11605	COG1684	flagellar biosynthetic protein fliR
CE453_RS11610	COG1987	bacterial-type flagellum assembly
CE453_RS11615	COG1677	Flagellar hook-basal body complex protein FliE
CE453_RS11620	COG1558	bacterial-type flagellum-dependent cell motility
CE453_RS11635	COG1338	Plays a role in the flagellum-specific transport system
CE453_RS11640	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CE453_RS11645	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CE453_RS11665	COG0110	maltose O-acetyltransferase activity
CE453_RS11705	COG0463	Glycosyl transferase, family 2
CE453_RS11745	COG4786	Flagellar basal body rod
CE453_RS11750	COG4786	Flagellar basal body rod
CE453_RS11760	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CE453_RS11770	COG2814	Major facilitator Superfamily
CE453_RS11780	COG1696	Membrane protein involved in D-alanine export
CE453_RS11785	COG1309	transcriptional regulator
CE453_RS11790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CE453_RS11795	COG1131	(ABC) transporter
CE453_RS11800	COG0842	Transport permease protein
CE453_RS11805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CE453_RS11825	COG3191	aminopeptidase activity
CE453_RS11845	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CE453_RS11860	COG1846	Transcriptional regulator
CE453_RS11860	COG0456	acetyltransferase
CE453_RS11870	COG4206	TonB-dependent receptor
CE453_RS11885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CE453_RS11895	COG0625	glutathione transferase activity
CE453_RS11905	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CE453_RS11920	COG0683	leucine binding
CE453_RS11945	COG0559	Belongs to the binding-protein-dependent transport system permease family
CE453_RS11955	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CE453_RS12025	COG3608	succinylglutamate desuccinylase aspartoacylase
CE453_RS12025	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CE453_RS12030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CE453_RS12040	COG5425	PFAM Usg family protein
CE453_RS12070	COG2308	Evidence 4 Homologs of previously reported genes of
CE453_RS12075	COG3189	MarR family transcriptional regulator
CE453_RS12080	COG2003	Belongs to the UPF0758 family
CE453_RS12085	COG0024	Methionine aminopeptidase
CE453_RS12095	COG1546	Belongs to the CinA family
CE453_RS12095	COG1058	Belongs to the CinA family
CE453_RS12105	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CE453_RS12150	COG1253	flavin adenine dinucleotide binding
CE453_RS12195	COG0583	DNA-binding transcription factor activity
CE453_RS12205	COG2890	protein-(glutamine-N5) methyltransferase activity
CE453_RS12230	COG3706	GGDEF domain
CE453_RS12270	COG1752	Esterase of the alpha-beta hydrolase superfamily
CE453_RS12280	COG0302	gtp cyclohydrolase
CE453_RS12295	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CE453_RS12300	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CE453_RS12330	COG0778	Nitroreductase
CE453_RS12410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CE453_RS12435	COG0601	transmembrane transport
CE453_RS12445	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS12450	COG4948	Mandelate Racemase Muconate Lactonizing
CE453_RS12465	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CE453_RS12485	COG1999	signal sequence binding
CE453_RS12540	COG2814	Major facilitator Superfamily
CE453_RS12545	COG1937	Protein conserved in bacteria
CE453_RS12570	COG5002	protein histidine kinase activity
CE453_RS12575	COG2204	response regulator
CE453_RS12630	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CE453_RS12650	COG0798	PFAM Bile acid sodium symporter
CE453_RS12675	COG0492	ferredoxin-NADP+ reductase activity
CE453_RS12685	COG2205	protein histidine kinase activity
CE453_RS12730	COG2217	Heavy metal translocating P-type atpase
CE453_RS12760	COG0492	ferredoxin-NADP+ reductase activity
CE453_RS12770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CE453_RS12775	COG0583	DNA-binding transcription factor activity
CE453_RS12780	COG0626	cystathionine gamma-synthase activity
CE453_RS12785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE453_RS12790	COG4597	amino acid ABC transporter
CE453_RS12795	COG0765	amino acid transport
CE453_RS12800	COG1126	abc transporter atp-binding protein
CE453_RS12835	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CE453_RS12885	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CE453_RS12890	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CE453_RS12900	COG0148	phosphopyruvate hydratase activity
CE453_RS12910	COG1993	acr, cog1993
CE453_RS12915	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CE453_RS12920	COG0651	ATP synthesis coupled electron transport
CE453_RS12925	COG3260	NADH ubiquinone oxidoreductase 20
CE453_RS12930	COG0649	NAD binding
CE453_RS12935	COG0651	ATP synthesis coupled electron transport
CE453_RS12945	COG0650	Formate hydrogenlyase subunit 4
CE453_RS12950	COG0537	adenosine 5'-monophosphoramidase activity
CE453_RS12965	COG0038	chloride channel
CE453_RS13000	COG0671	phosphoesterase, PA-phosphatase related
CE453_RS13040	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CE453_RS13125	COG0583	DNA-binding transcription factor activity
CE453_RS13130	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CE453_RS13165	COG3938	Belongs to the proline racemase family
CE453_RS13170	COG4797	methyltransferase
CE453_RS13170	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CE453_RS13295	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CE453_RS13300	COG4774	siderophore transport
CE453_RS13315	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CE453_RS13320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CE453_RS13330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CE453_RS13345	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CE453_RS13350	COG0081	regulation of translation
CE453_RS13355	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CE453_RS13360	COG0222	ribosome binding
CE453_RS13365	COG0085	RNA polymerase activity
CE453_RS13370	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CE453_RS13375	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CE453_RS13380	COG0049	tRNA binding
CE453_RS13385	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CE453_RS13390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CE453_RS13395	COG0051	transcription antitermination factor activity, RNA binding
CE453_RS13400	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CE453_RS13405	COG0088	Forms part of the polypeptide exit tunnel
CE453_RS13410	COG0089	rRNA binding
CE453_RS13415	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CE453_RS13420	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CE453_RS13425	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CE453_RS13430	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CE453_RS13435	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CE453_RS13440	COG0255	Belongs to the universal ribosomal protein uL29 family
CE453_RS13445	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CE453_RS13450	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CE453_RS13455	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CE453_RS13460	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CE453_RS13465	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CE453_RS13470	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CE453_RS13475	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CE453_RS13480	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CE453_RS13485	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CE453_RS13490	COG1841	ribosomal large subunit assembly
CE453_RS13495	COG0200	Binds to the 23S rRNA
CE453_RS13500	COG0201	protein transport
CE453_RS13505	COG0563	adenylate kinase activity
CE453_RS13515	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CE453_RS13520	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CE453_RS13525	COG0202	RNA polymerase activity
CE453_RS13530	COG0203	ribosomal protein L17
CE453_RS13535	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CE453_RS13545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CE453_RS13550	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CE453_RS13565	COG0564	pseudouridine synthase activity
CE453_RS13575	COG0546	phosphoglycolate phosphatase activity
CE453_RS13585	COG4770	biotin carboxylase activity
CE453_RS13590	COG0625	glutathione transferase activity
CE453_RS13595	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CE453_RS13615	COG5265	(ABC) transporter
CE453_RS13635	COG1960	acyl-CoA dehydrogenase activity
CE453_RS13655	COG0598	Magnesium transport protein CorA
CE453_RS13680	COG0321	lipoyl(octanoyl) transferase activity
CE453_RS13690	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CE453_RS13700	COG0412	Dienelactone hydrolase
CE453_RS13705	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS13730	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS13745	COG1846	Transcriptional regulator
CE453_RS13755	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CE453_RS13765	COG0484	heat shock protein binding
CE453_RS13770	COG1686	Belongs to the peptidase S11 family
CE453_RS13780	COG2721	sulfolactate sulfo-lyase activity
CE453_RS13790	COG0436	Aminotransferase
CE453_RS13795	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CE453_RS13800	COG1278	Cold shock
CE453_RS13810	COG0316	Belongs to the HesB IscA family
CE453_RS13820	COG0018	arginyl-trna synthetase
CE453_RS13830	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CE453_RS13835	COG1472	Belongs to the glycosyl hydrolase 3 family
CE453_RS13840	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CE453_RS13845	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CE453_RS13850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CE453_RS13855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CE453_RS13860	COG0805	protein transport
CE453_RS13865	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CE453_RS13870	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CE453_RS13875	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CE453_RS13890	COG1862	Preprotein translocase
CE453_RS13895	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CE453_RS13905	COG3737	Protein of unknown function (DUF498/DUF598)
CE453_RS13915	COG0477	Major facilitator Superfamily
CE453_RS13920	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CE453_RS13940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CE453_RS13945	COG1024	Enoyl-CoA hydratase
CE453_RS13950	COG0477	Major facilitator Superfamily
CE453_RS13955	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CE453_RS13960	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CE453_RS13965	COG1845	cytochrome c oxidase, subunit III
CE453_RS13970	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CE453_RS14005	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CE453_RS14020	COG0765	amino acid transport
CE453_RS14030	COG1126	abc transporter atp-binding protein
CE453_RS14035	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CE453_RS14045	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CE453_RS14065	COG0511	ligase activity, forming carbon-carbon bonds
CE453_RS14070	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CE453_RS14070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CE453_RS14075	COG0436	Aminotransferase
CE453_RS14080	COG0668	transmembrane transport
CE453_RS14090	COG1530	ribonuclease E activity
CE453_RS14095	COG0860	N-Acetylmuramoyl-L-alanine amidase
CE453_RS14110	COG0848	biopolymer transport protein
CE453_RS14130	COG0657	acetylesterase activity
CE453_RS14135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CE453_RS14145	COG0483	inositol monophosphate 1-phosphatase activity
CE453_RS14155	COG0395	ABC-type sugar transport system, permease component
CE453_RS14165	COG1653	transport
CE453_RS14170	COG3842	ATPase activity
CE453_RS14175	COG1126	abc transporter atp-binding protein
CE453_RS14180	COG0765	amino acid transport
CE453_RS14185	COG0765	amino acid transport
CE453_RS14190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE453_RS14210	COG0747	negative chemotaxis
CE453_RS14225	COG0444	Belongs to the ABC transporter superfamily
CE453_RS14230	COG4608	Belongs to the ABC transporter superfamily
CE453_RS14245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE453_RS14250	COG0601	transmembrane transport
CE453_RS14255	COG1414	Transcriptional regulator
CE453_RS14260	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CE453_RS14270	COG1960	acyl-CoA dehydrogenase activity
CE453_RS14280	COG1609	Transcriptional regulator
CE453_RS14290	COG1024	Enoyl-CoA hydratase
CE453_RS14295	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS14300	COG0765	amino acid transport
CE453_RS14305	COG0765	amino acid transport
CE453_RS14310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE453_RS14315	COG1126	abc transporter atp-binding protein
CE453_RS14320	COG2942	2-epimerase
CE453_RS14335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CE453_RS14365	COG4106	trans-aconitate 2-methyltransferase activity
CE453_RS14375	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CE453_RS14380	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CE453_RS14385	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CE453_RS14395	COG0649	NAD binding
CE453_RS14405	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CE453_RS14410	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CE453_RS14420	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CE453_RS14430	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CE453_RS14440	COG0713	ATP synthesis coupled electron transport
CE453_RS14455	COG1007	ATP synthesis coupled electron transport
CE453_RS14470	COG0346	lactoylglutathione lyase activity
CE453_RS14505	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CE453_RS14520	COG1160	GTP binding
CE453_RS14525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CE453_RS14525	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CE453_RS14535	COG4221	oxidoreductase activity
CE453_RS14540	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CE453_RS14555	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CE453_RS14560	COG0305	Participates in initiation and elongation during chromosome replication
CE453_RS14565	COG0359	binds to the 23S rRNA
CE453_RS14575	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CE453_RS14580	COG0360	Binds together with S18 to 16S ribosomal RNA
CE453_RS14585	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CE453_RS14595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CE453_RS14600	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CE453_RS14605	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CE453_RS14610	COG1561	YicC-like family, N-terminal region
CE453_RS14615	COG0194	GDP metabolic process
CE453_RS14620	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CE453_RS14630	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CE453_RS14645	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CE453_RS14675	COG0488	(ABC) transporter
CE453_RS14685	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CE453_RS14690	COG0442	prolyl-tRNA aminoacylation
CE453_RS14700	COG1136	(ABC) transporter
CE453_RS14710	COG1335	isochorismatase
CE453_RS14715	COG2378	regulation of single-species biofilm formation
CE453_RS14735	COG0052	Belongs to the universal ribosomal protein uS2 family
CE453_RS14740	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CE453_RS14745	COG0528	UMP kinase activity
CE453_RS14750	COG0346	lactoylglutathione lyase activity
CE453_RS14755	COG0233	cytoplasmic translational termination
CE453_RS14760	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CE453_RS14765	COG0575	Belongs to the CDS family
CE453_RS14770	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CE453_RS14775	COG0750	zinc metalloprotease
CE453_RS14780	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CE453_RS14785	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CE453_RS14790	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CE453_RS14795	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CE453_RS14800	COG3494	Protein of unknown function (DUF1009)
CE453_RS14805	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CE453_RS14815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CE453_RS14825	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CE453_RS14830	COG0303	'Molybdopterin
CE453_RS14835	COG0315	cyclic pyranopterin monophosphate synthase activity
CE453_RS14845	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CE453_RS14855	COG0667	Aldo Keto reductase
CE453_RS14895	COG2301	Belongs to the HpcH HpaI aldolase family
CE453_RS14905	COG0679	Auxin Efflux Carrier
CE453_RS14910	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CE453_RS14915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CE453_RS14925	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CE453_RS14940	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS14945	COG1595	DNA-templated transcription, initiation
CE453_RS14980	COG0765	amino acid transport
CE453_RS14985	COG1126	abc transporter atp-binding protein
CE453_RS14995	COG4608	Belongs to the ABC transporter superfamily
CE453_RS15000	COG0444	Belongs to the ABC transporter superfamily
CE453_RS15005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE453_RS15010	COG0601	transmembrane transport
CE453_RS15015	COG0747	negative chemotaxis
CE453_RS15040	COG4774	siderophore transport
CE453_RS15045	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CE453_RS15050	COG4208	sulfate ABC transporter
CE453_RS15055	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CE453_RS15060	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CE453_RS15065	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CE453_RS15065	COG1648	precorrin-2 dehydrogenase activity
CE453_RS15080	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CE453_RS15115	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CE453_RS15120	COG0488	(ABC) transporter
CE453_RS15125	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CE453_RS15145	COG4176	ABC-type proline glycine betaine transport system permease component
CE453_RS15150	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CE453_RS15155	COG0629	single-stranded DNA binding
CE453_RS15160	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CE453_RS15165	COG0163	prenyltransferase activity
CE453_RS15170	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CE453_RS15180	COG0826	peptidase U32
CE453_RS15230	COG2151	metal-sulfur cluster biosynthetic enzyme
CE453_RS15260	COG0714	Associated with various cellular activities
CE453_RS15265	COG3256	nitric oxide reductase
CE453_RS15280	COG4459	periplasmic nitrate reductase
CE453_RS15290	COG3062	negative regulation of establishment of protein localization
CE453_RS15295	COG0243	molybdopterin cofactor binding
CE453_RS15300	COG3043	anaerobic respiration
CE453_RS15305	COG3005	denitrification pathway
CE453_RS15310	COG0384	phenazine biosynthesis protein PhzF
CE453_RS15320	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CE453_RS15325	COG0316	Belongs to the HesB IscA family
CE453_RS15330	COG3706	GGDEF domain
CE453_RS15335	COG0513	Belongs to the DEAD box helicase family
CE453_RS15355	COG0187	DNA topoisomerase II activity
CE453_RS15380	COG0174	glutamine synthetase
CE453_RS15385	COG0347	Belongs to the P(II) protein family
CE453_RS15390	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CE453_RS15390	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CE453_RS15435	COG1053	succinate dehydrogenase
CE453_RS15440	COG1053	succinate dehydrogenase
CE453_RS15455	COG0559	Belongs to the binding-protein-dependent transport system permease family
CE453_RS15465	COG0673	inositol 2-dehydrogenase activity
CE453_RS15470	COG1414	Transcriptional regulator
CE453_RS15495	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CE453_RS15500	COG0508	dehydrogenase complex catalyzes the overall conversion of
CE453_RS15500	COG0022	dehydrogenase e1 component
CE453_RS15505	COG0508	dehydrogenase complex catalyzes the overall conversion of
CE453_RS15510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CE453_RS15525	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CE453_RS15530	COG2095	MarC family integral membrane protein
CE453_RS15545	COG0740	serine-type endopeptidase activity
CE453_RS15550	COG1473	amidohydrolase
CE453_RS15555	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CE453_RS15595	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CE453_RS15605	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CE453_RS15615	COG0583	DNA-binding transcription factor activity
CE453_RS15620	COG0445	tRNA wobble uridine modification
CE453_RS15625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CE453_RS15635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CE453_RS15645	COG0596	Alpha beta hydrolase
CE453_RS15650	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CE453_RS15655	COG3485	protocatechuate 3,4-dioxygenase
CE453_RS15660	COG3485	protocatechuate 3,4-dioxygenase
CE453_RS15665	COG0183	Belongs to the thiolase family
CE453_RS15680	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CE453_RS15680	COG1082	Xylose isomerase domain protein TIM barrel
CE453_RS15695	COG2837	iron assimilation
CE453_RS15710	COG0542	response to heat
CE453_RS15745	COG0071	Belongs to the small heat shock protein (HSP20) family
CE453_RS15755	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CE453_RS15770	COG0668	transmembrane transport
CE453_RS15780	COG1294	oxidase, subunit
CE453_RS15785	COG1271	oxidase subunit
CE453_RS15795	COG3781	membrane
CE453_RS15805	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CE453_RS15805	COG0321	lipoyl(octanoyl) transferase activity
CE453_RS15810	COG0084	hydrolase, TatD family'
CE453_RS15815	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CE453_RS15825	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CE453_RS15830	COG1686	Belongs to the peptidase S11 family
CE453_RS15905	COG3617	BRO family, N-terminal domain
CE453_RS15930	COG0251	oxidation-reduction process
CE453_RS15940	COG1802	Transcriptional regulator
CE453_RS15955	COG3842	ATPase activity
CE453_RS15960	COG1176	ABC-type spermidine putrescine transport system, permease component I
CE453_RS15985	COG0583	DNA-binding transcription factor activity
CE453_RS15990	COG0604	alcohol dehydrogenase
CE453_RS15990	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS15990	COG3321	synthase
CE453_RS15995	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CE453_RS16000	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CE453_RS16020	COG2832	Protein of unknown function (DUF454)
CE453_RS16025	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CE453_RS16030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CE453_RS16035	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CE453_RS16050	COG0754	glutathionylspermidine amidase activity
CE453_RS16070	COG0504	CTP synthase activity
CE453_RS16080	COG0149	triose-phosphate isomerase activity
CE453_RS16090	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CE453_RS16125	COG0525	valine-tRNA ligase activity
CE453_RS16145	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CE453_RS16160	COG0415	Belongs to the DNA photolyase family
CE453_RS16170	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CE453_RS16175	COG2897	thiosulfate sulfurtransferase activity
CE453_RS16185	COG1720	tRNA m6t6A37 methyltransferase activity
CE453_RS16190	COG3585	molybdate ion transport
CE453_RS16195	COG0725	ABC transporter, periplasmic molybdate-binding protein
CE453_RS16200	COG4149	molybdate abc transporter
CE453_RS16205	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CE453_RS16220	COG1473	amidohydrolase
CE453_RS16225	COG2137	regulation of response to DNA damage stimulus
CE453_RS16235	COG3956	TIGRFAM MazG family protein
CE453_RS16245	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CE453_RS16250	COG1923	regulation of RNA biosynthetic process
CE453_RS16255	COG2204	response regulator
CE453_RS16260	COG5000	phosphorelay sensor kinase activity
CE453_RS16265	COG2204	response regulator
CE453_RS16280	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CE453_RS16280	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CE453_RS16285	COG1058	Belongs to the CinA family
CE453_RS16285	COG1546	Belongs to the CinA family
CE453_RS16290	COG2867	negative regulation of translational initiation
CE453_RS16295	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CE453_RS16305	COG2005	Transcriptional regulator
CE453_RS16310	COG1956	GAF domain-containing protein
CE453_RS16330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CE453_RS16335	COG1942	4-Oxalocrotonate Tautomerase
CE453_RS16340	COG0719	Fe-S assembly protein
CE453_RS16345	COG0396	ATPase activity
CE453_RS16350	COG0719	Fe-S assembly protein
CE453_RS16360	COG2945	thiolester hydrolase activity
CE453_RS16375	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CE453_RS16385	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CE453_RS16390	COG0739	heme binding
CE453_RS16420	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CE453_RS16450	COG0798	PFAM Bile acid sodium symporter
CE453_RS16455	COG1393	Belongs to the ArsC family
CE453_RS16495	COG2391	methyltransferase activity
CE453_RS16505	COG0640	Transcriptional regulator
CE453_RS16510	COG3453	Protein conserved in bacteria
CE453_RS16510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CE453_RS16530	COG2217	Heavy metal translocating P-type atpase
CE453_RS16585	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CE453_RS16595	COG3243	poly(R)-hydroxyalkanoic acid synthase
CE453_RS16610	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CE453_RS16615	COG1136	(ABC) transporter
CE453_RS16620	COG4591	ABC-type transport system involved in lipoprotein release permease component
CE453_RS16625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CE453_RS16630	COG1063	alcohol dehydrogenase
CE453_RS16640	COG1127	ABC transporter
CE453_RS16645	COG0842	Transport permease protein
CE453_RS16650	COG1129	ABC transporter
CE453_RS16650	COG0842	Transport permease protein
CE453_RS16655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CE453_RS16665	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CE453_RS16675	COG3038	cytochrome b561
CE453_RS16685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CE453_RS16690	COG4191	Histidine kinase
CE453_RS16690	COG0784	Response regulator, receiver
CE453_RS16705	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CE453_RS16715	COG4572	Cation transport regulator
CE453_RS16750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CE453_RS16795	COG3119	arylsulfatase activity
CE453_RS16800	COG3119	arylsulfatase activity
CE453_RS16805	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS16820	COG2721	sulfolactate sulfo-lyase activity
CE453_RS16825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CE453_RS16830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CE453_RS16845	COG2084	Dehydrogenase
CE453_RS16870	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CE453_RS16875	COG1609	Transcriptional regulator
CE453_RS16885	COG1175	transmembrane transport
CE453_RS16890	COG0395	ABC-type sugar transport system, permease component
CE453_RS16895	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CE453_RS16905	COG0235	Class ii aldolase
CE453_RS16935	COG0028	Belongs to the TPP enzyme family
CE453_RS16940	COG1846	Transcriptional regulator
CE453_RS16950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CE453_RS16975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CE453_RS16980	COG0697	spore germination
CE453_RS16985	COG1802	Transcriptional regulator
CE453_RS16995	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS17010	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CE453_RS17025	COG0765	amino acid transport
CE453_RS17030	COG0765	amino acid transport
CE453_RS17035	COG1126	abc transporter atp-binding protein
CE453_RS17060	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS17065	COG1802	Transcriptional regulator
CE453_RS17080	COG1129	ABC transporter
CE453_RS17085	COG1250	3-hydroxyacyl-CoA dehydrogenase
CE453_RS17090	COG3246	L-lysine catabolic process to acetate
CE453_RS17105	COG1175	transmembrane transport
CE453_RS17110	COG0395	ABC-type sugar transport system, permease component
CE453_RS17115	COG1653	transport
CE453_RS17120	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CE453_RS17125	COG0483	inositol monophosphate 1-phosphatase activity
CE453_RS17130	COG2390	Transcriptional regulator
CE453_RS17140	COG1070	Carbohydrate kinase
CE453_RS17145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CE453_RS17150	COG2390	Transcriptional regulator
CE453_RS17160	COG1175	transmembrane transport
CE453_RS17165	COG0395	ABC-type sugar transport system, permease component
CE453_RS17170	COG0584	glycerophosphoryl diester phosphodiesterase
CE453_RS17190	COG1595	DNA-templated transcription, initiation
CE453_RS17200	COG0028	Belongs to the TPP enzyme family
CE453_RS17240	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CE453_RS17250	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CE453_RS17290	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CE453_RS17325	COG1940	carbohydrate kinase activity
CE453_RS17340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE453_RS17345	COG0346	lactoylglutathione lyase activity
CE453_RS17360	COG1335	isochorismatase
CE453_RS17365	COG0655	NAD(P)H dehydrogenase (quinone) activity
CE453_RS17370	COG0583	DNA-binding transcription factor activity
CE453_RS17390	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CE453_RS17410	COG4214	carbohydrate transport
CE453_RS17420	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CE453_RS17430	COG1802	Transcriptional regulator
CE453_RS17445	COG1733	regulation of RNA biosynthetic process
CE453_RS17455	COG1741	Belongs to the pirin family
CE453_RS17460	COG1335	isochorismatase
CE453_RS17475	COG0583	DNA-binding transcription factor activity
CE453_RS17540	COG0604	alcohol dehydrogenase
CE453_RS17540	COG3321	synthase
CE453_RS17545	COG0400	carboxylic ester hydrolase activity
CE453_RS17575	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CE453_RS17580	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CE453_RS17585	COG0740	serine-type endopeptidase activity
CE453_RS17590	COG0544	peptidyl-prolyl cis-trans isomerase activity
CE453_RS17600	COG2132	Multicopper oxidase
CE453_RS17605	COG3265	gluconokinase activity
CE453_RS17610	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CE453_RS17625	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CE453_RS17630	COG0557	exoribonuclease II activity
CE453_RS17670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CE453_RS17700	COG0537	adenosine 5'-monophosphoramidase activity
CE453_RS17705	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CE453_RS17710	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CE453_RS17715	COG1595	DNA-templated transcription, initiation
CE453_RS17740	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CE453_RS17745	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CE453_RS17755	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CE453_RS17785	COG0343	queuine tRNA-ribosyltransferase activity
CE453_RS17790	COG1393	Belongs to the ArsC family
CE453_RS17795	COG0625	glutathione transferase activity
CE453_RS17820	COG1309	transcriptional regulator
CE453_RS17855	COG1228	amidohydrolase
CE453_RS17860	COG1228	amidohydrolase
CE453_RS17865	COG1177	transmembrane transport
CE453_RS17870	COG3842	ATPase activity
CE453_RS17880	COG1176	ABC-type spermidine putrescine transport system, permease component I
CE453_RS17910	COG1176	ABC-type spermidine putrescine transport system, permease component I
CE453_RS17915	COG3842	ATPase activity
CE453_RS17925	COG1024	Enoyl-CoA hydratase
CE453_RS17945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CE453_RS17960	COG0765	amino acid transport
CE453_RS17965	COG0765	amino acid transport
CE453_RS17970	COG1473	amidohydrolase
CE453_RS17975	COG0626	cystathionine gamma-synthase activity
CE453_RS17980	COG3186	Phenylalanine-4-hydroxylase
CE453_RS17990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE453_RS18010	COG4608	Belongs to the ABC transporter superfamily
CE453_RS18015	COG0444	Belongs to the ABC transporter superfamily
CE453_RS18020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CE453_RS18020	COG0519	Catalyzes the synthesis of GMP from XMP
CE453_RS18035	COG0584	glycerophosphoryl diester phosphodiesterase
CE453_RS18040	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CE453_RS18050	COG1126	abc transporter atp-binding protein
CE453_RS18055	COG0765	amino acid transport
CE453_RS18060	COG4597	amino acid ABC transporter
CE453_RS18065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE453_RS18070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE453_RS18075	COG0626	cystathionine gamma-synthase activity
CE453_RS18080	COG0248	Ppx GppA phosphatase
CE453_RS18085	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CE453_RS18095	COG0628	permease
CE453_RS18105	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CE453_RS18110	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CE453_RS18125	COG3237	CsbD-like
CE453_RS18140	COG0105	UTP biosynthetic process
CE453_RS18155	COG0625	glutathione transferase activity
CE453_RS18170	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CE453_RS18190	COG0154	amidase activity
CE453_RS18195	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CE453_RS18200	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CE453_RS18205	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CE453_RS18215	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CE453_RS18240	COG0758	DNA mediated transformation
CE453_RS18245	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CE453_RS18250	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CE453_RS18260	COG0540	Belongs to the ATCase OTCase family
CE453_RS18265	COG2814	Major facilitator Superfamily
CE453_RS18280	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CE453_RS18285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CE453_RS18310	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS18320	COG1024	Enoyl-CoA hydratase
CE453_RS18325	COG1960	acyl-CoA dehydrogenase activity
CE453_RS18340	COG0529	Catalyzes the synthesis of activated sulfate
CE453_RS18340	COG2895	sulfate adenylyltransferase (ATP) activity
CE453_RS18345	COG0175	sulfate reduction
CE453_RS18350	COG0175	sulfate reduction
CE453_RS18355	COG0587	DNA-directed DNA polymerase activity
CE453_RS18370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CE453_RS18410	COG2766	serine protein kinase
CE453_RS18415	COG2718	Belongs to the UPF0229 family
CE453_RS18420	COG2719	SpoVR family
CE453_RS18440	COG1053	succinate dehydrogenase
CE453_RS18445	COG1802	Transcriptional regulator
CE453_RS18455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CE453_RS18470	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CE453_RS18475	COG3842	ATPase activity
CE453_RS18480	COG3842	ATPase activity
CE453_RS18485	COG3833	ABC-type maltose transport systems, permease component
CE453_RS18500	COG1802	Transcriptional regulator
CE453_RS18505	COG2828	Protein conserved in bacteria
CE453_RS18515	COG2059	Chromate
CE453_RS18530	COG0747	negative chemotaxis
CE453_RS18555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CE453_RS18560	COG0601	transmembrane transport
CE453_RS18575	COG0747	negative chemotaxis
CE453_RS18610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE453_RS18615	COG4597	amino acid ABC transporter
CE453_RS18620	COG0765	amino acid transport
CE453_RS18660	COG0683	leucine binding
CE453_RS18665	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS18670	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS18675	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS18680	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS18685	COG1053	succinate dehydrogenase
CE453_RS18695	COG0402	S-adenosylhomocysteine deaminase activity
CE453_RS18705	COG2131	deaminase
CE453_RS18725	COG1053	succinate dehydrogenase
CE453_RS18735	COG1024	Enoyl-CoA hydratase
CE453_RS18745	COG0583	DNA-binding transcription factor activity
CE453_RS18755	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CE453_RS18785	COG0436	Aminotransferase
CE453_RS18810	COG0179	Fumarylacetoacetate (FAA) hydrolase
CE453_RS18820	COG0010	Belongs to the arginase family
CE453_RS18830	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CE453_RS18835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CE453_RS18845	COG1024	Enoyl-CoA hydratase
CE453_RS18850	COG1832	CoA-binding protein
CE453_RS18870	COG1612	heme a metabolic process
CE453_RS18885	COG0726	polysaccharide deacetylase
CE453_RS18920	COG2076	Multidrug Resistance protein
CE453_RS18950	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CE453_RS18955	COG0400	carboxylic ester hydrolase activity
CE453_RS18960	COG0346	lactoylglutathione lyase activity
CE453_RS18970	COG0583	DNA-binding transcription factor activity
CE453_RS18985	COG0776	regulation of translation
CE453_RS18990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CE453_RS18995	COG0416	fatty acid biosynthetic process
CE453_RS19015	COG0697	spore germination
CE453_RS19020	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CE453_RS19025	COG3257	ureidoglycine aminohydrolase activity
CE453_RS19030	COG2814	Major facilitator Superfamily
CE453_RS19035	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CE453_RS19045	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CE453_RS19055	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CE453_RS19055	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CE453_RS19060	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CE453_RS19065	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CE453_RS19080	COG2989	Protein conserved in bacteria
CE453_RS19105	COG0113	porphobilinogen synthase activity
CE453_RS19115	COG0559	Belongs to the binding-protein-dependent transport system permease family
CE453_RS19120	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CE453_RS19130	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CE453_RS19135	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CE453_RS19140	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CE453_RS19140	COG0473	3-isopropylmalate dehydrogenase activity
CE453_RS19170	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CE453_RS19175	COG1381	Involved in DNA repair and RecF pathway recombination
CE453_RS19195	COG1758	RNA polymerase activity
CE453_RS19205	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CE453_RS19210	COG0736	holo-[acyl-carrier-protein] synthase activity
CE453_RS19215	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CE453_RS19230	COG0571	ribonuclease III activity
CE453_RS19235	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CE453_RS19250	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CE453_RS19260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CE453_RS19265	COG0741	lytic transglycosylase activity
CE453_RS19280	COG2885	chlorophyll binding
CE453_RS19280	COG3047	cAMP biosynthetic process
CE453_RS19295	COG0729	surface antigen
CE453_RS19340	COG1012	belongs to the aldehyde dehydrogenase family
CE453_RS19345	COG5001	Diguanylate cyclase
CE453_RS19345	COG4251	negative regulation of phosphorylation
CE453_RS19345	COG3706	GGDEF domain
CE453_RS19345	COG2203	Gaf domain
CE453_RS19360	COG3038	cytochrome b561
CE453_RS19380	COG0604	alcohol dehydrogenase
CE453_RS19390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CE453_RS19395	COG0527	aspartate kinase activity
CE453_RS19410	COG3011	Protein conserved in bacteria
CE453_RS19420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CE453_RS19440	COG1024	Enoyl-CoA hydratase
CE453_RS19445	COG1902	pentaerythritol trinitrate reductase activity
CE453_RS19450	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CE453_RS19465	COG2022	thiamine diphosphate biosynthetic process
CE453_RS19490	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CE453_RS19495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CE453_RS19545	COG2030	dehydratase
CE453_RS19555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE453_RS19560	COG0601	transmembrane transport
CE453_RS19565	COG1024	Enoyl-CoA hydratase
CE453_RS19575	COG4178	(ABC) transporter
CE453_RS19585	COG3964	amidohydrolase
CE453_RS19595	COG0601	transmembrane transport
CE453_RS19600	COG0747	negative chemotaxis
CE453_RS19605	COG1921	L-seryl-tRNASec selenium transferase activity
CE453_RS19610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CE453_RS19615	COG4948	Mandelate Racemase Muconate Lactonizing
CE453_RS19625	COG1175	transmembrane transport
CE453_RS19630	COG0395	ABC-type sugar transport system, permease component
CE453_RS19645	COG1414	Transcriptional regulator
CE453_RS19655	COG3386	PFAM SMP-30 Gluconolaconase
CE453_RS19665	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CE453_RS19670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CE453_RS19685	COG2188	Transcriptional regulator
CE453_RS19725	COG0395	ABC-type sugar transport system, permease component
CE453_RS19730	COG1175	transmembrane transport
CE453_RS19745	COG1609	Transcriptional regulator
CE453_RS19750	COG4948	Mandelate Racemase Muconate Lactonizing
CE453_RS19765	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CE453_RS19775	COG0438	transferase activity, transferring glycosyl groups
CE453_RS19785	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CE453_RS19810	COG5001	Diguanylate cyclase
CE453_RS19810	COG2203	Gaf domain
CE453_RS19810	COG3706	GGDEF domain
CE453_RS19810	COG4251	negative regulation of phosphorylation
CE453_RS19815	COG2201	protein-glutamate methylesterase activity
CE453_RS19830	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CE453_RS19830	COG0457	Tetratricopeptide repeat
CE453_RS19845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CE453_RS19850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CE453_RS19855	COG3383	formate dehydrogenase (NAD+) activity
CE453_RS19855	COG0243	molybdopterin cofactor binding
CE453_RS19860	COG0243	molybdopterin cofactor binding
CE453_RS19860	COG3383	formate dehydrogenase (NAD+) activity
CE453_RS19865	COG0437	4 iron, 4 sulfur cluster binding
CE453_RS19870	COG2864	formate dehydrogenase
CE453_RS19890	COG3276	selenocysteine insertion sequence binding
CE453_RS19900	COG0709	Synthesizes selenophosphate from selenide and ATP
CE453_RS19905	COG1305	Transglutaminase-like
CE453_RS19935	COG2186	Transcriptional regulator
CE453_RS19940	COG2807	transmembrane transport
CE453_RS19945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CE453_RS19950	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CE453_RS19955	COG2011	ABC-type metal ion transport system permease component
CE453_RS19960	COG1176	ABC-type spermidine putrescine transport system, permease component I
CE453_RS19965	COG3842	ATPase activity
CE453_RS19980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE453_RS19985	COG0601	transmembrane transport
CE453_RS19990	COG0747	negative chemotaxis
CE453_RS20015	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CE453_RS20020	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS20025	COG0424	maF-like protein
CE453_RS20035	COG1183	phosphatidylcholine synthase activity
CE453_RS20040	COG0688	phosphatidylethanolamine metabolic process
CE453_RS20050	COG5265	(ABC) transporter
CE453_RS20060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CE453_RS20065	COG0215	cysteine-tRNA ligase activity
CE453_RS20075	COG3045	CreA protein
CE453_RS20105	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CE453_RS20115	COG1846	Transcriptional regulator
CE453_RS20120	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CE453_RS20130	COG0477	Major facilitator Superfamily
CE453_RS20135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CE453_RS20150	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CE453_RS20155	COG2226	methyltransferase
CE453_RS20185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CE453_RS20195	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CE453_RS20205	COG0546	phosphoglycolate phosphatase activity
CE453_RS20235	COG1388	LysM domain
CE453_RS20235	COG1376	ErfK ybiS ycfS ynhG family protein
CE453_RS20245	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CE453_RS20265	COG0840	transmembrane signaling receptor activity
CE453_RS20275	COG0697	spore germination
CE453_RS20280	COG2084	Dehydrogenase
CE453_RS20285	COG0024	Methionine aminopeptidase
CE453_RS20305	COG2814	Major facilitator Superfamily
CE453_RS20325	COG0519	Catalyzes the synthesis of GMP from XMP
CE453_RS20330	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CE453_RS20340	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CE453_RS20350	COG1573	uracil-dna glycosylase
CE453_RS20375	COG2205	protein histidine kinase activity
CE453_RS20375	COG2202	Pas domain
CE453_RS20380	COG1181	Belongs to the D-alanine--D-alanine ligase family
CE453_RS20385	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CE453_RS20390	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CE453_RS20405	COG0730	response to heat
CE453_RS20410	COG5507	3-demethylubiquinone-9 3-methyltransferase
CE453_RS20465	COG1204	response to ionizing radiation
CE453_RS20480	COG0747	negative chemotaxis
CE453_RS20485	COG4608	Belongs to the ABC transporter superfamily
CE453_RS20490	COG0444	Belongs to the ABC transporter superfamily
CE453_RS20500	COG0601	transmembrane transport
CE453_RS20505	COG2072	flavoprotein involved in K transport
CE453_RS20525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CE453_RS20530	COG4208	sulfate ABC transporter
CE453_RS20535	COG1175	transmembrane transport
CE453_RS20550	COG1802	Transcriptional regulator
CE453_RS20555	COG1312	Catalyzes the dehydration of D-mannonate
CE453_RS20560	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CE453_RS20565	COG1840	ABC-type Fe3 transport system, periplasmic component
CE453_RS20575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CE453_RS20585	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CE453_RS20590	COG0308	aminopeptidase N
CE453_RS20595	COG2202	Pas domain
CE453_RS20595	COG2205	protein histidine kinase activity
CE453_RS20600	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CE453_RS20610	COG0745	RESPONSE REGULATOR receiver
CE453_RS20615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CE453_RS20620	COG3088	subunit of a heme lyase
CE453_RS20625	COG1138	Cytochrome C-type biogenesis protein
CE453_RS20630	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CE453_RS20635	COG4235	cytochrome complex assembly
CE453_RS20740	COG4695	Portal protein
CE453_RS20760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CE453_RS20765	COG1914	H( )-stimulated, divalent metal cation uptake system
CE453_RS20770	COG0433	COG0433 Predicted ATPase
CE453_RS20785	COG0351	phosphomethylpyrimidine kinase
CE453_RS20800	COG1177	transmembrane transport
CE453_RS20805	COG1176	ABC-type spermidine putrescine transport system, permease component I
CE453_RS20810	COG3842	ATPase activity
CE453_RS20815	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CE453_RS20855	COG1703	isobutyryl-CoA mutase activity
CE453_RS20880	COG0280	phosphate acetyltransferase
CE453_RS20880	COG0281	malic enzyme
CE453_RS20890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CE453_RS20895	COG0402	S-adenosylhomocysteine deaminase activity
CE453_RS20905	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CE453_RS20915	COG3845	ABC transporter
CE453_RS20920	COG4603	Belongs to the binding-protein-dependent transport system permease family
CE453_RS20925	COG1079	Belongs to the binding-protein-dependent transport system permease family
CE453_RS20955	COG0633	Ferredoxin
CE453_RS20970	COG0305	Participates in initiation and elongation during chromosome replication
CE453_RS20985	COG1127	ABC transporter
CE453_RS20990	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CE453_RS21000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CE453_RS21020	COG0789	Transcriptional regulator
CE453_RS21030	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CE453_RS21040	COG3395	kinase activity
CE453_RS21050	COG0601	transmembrane transport
CE453_RS21055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE453_RS21085	COG3964	amidohydrolase
CE453_RS21100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE453_RS21105	COG0601	transmembrane transport
CE453_RS21110	COG0747	negative chemotaxis
CE453_RS21125	COG0534	Mate efflux family protein
CE453_RS21130	COG1388	LysM domain
CE453_RS21130	COG1376	ErfK ybiS ycfS ynhG family protein
CE453_RS21145	COG0789	Transcriptional regulator
CE453_RS21155	COG1388	LysM domain
CE453_RS21155	COG1376	ErfK ybiS ycfS ynhG family protein
CE453_RS21185	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CE453_RS21190	COG0459	protein refolding
CE453_RS21200	COG4178	(ABC) transporter
CE453_RS21210	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CE453_RS21215	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CE453_RS21220	COG0124	histidyl-tRNA synthetase
CE453_RS21225	COG0247	lactate metabolic process
CE453_RS21235	COG0277	FAD linked oxidase domain protein
CE453_RS21240	COG0277	FAD linked oxidase domain protein
CE453_RS21245	COG0583	DNA-binding transcription factor activity
CE453_RS21260	COG0436	Aminotransferase
CE453_RS21265	COG1970	mechanosensitive ion channel activity
CE453_RS21270	COG2205	protein histidine kinase activity
CE453_RS21285	COG1522	sequence-specific DNA binding
CE453_RS21290	COG1722	exodeoxyribonuclease VII activity
CE453_RS21310	COG2249	NAD(P)H dehydrogenase (quinone) activity
CE453_RS21315	COG1741	Belongs to the pirin family
CE453_RS21325	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CE453_RS21330	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CE453_RS21340	COG2135	peptidase activity
CE453_RS21350	COG0277	FAD linked oxidase domain protein
CE453_RS21355	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CE453_RS21365	COG1823	symporter activity
CE453_RS21370	COG0598	Magnesium transport protein CorA
CE453_RS21375	COG3273	potassium ion transport
CE453_RS21375	COG0471	metal ion transport
CE453_RS21385	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS21390	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS21400	COG1960	acyl-CoA dehydrogenase activity
CE453_RS21405	COG0009	L-threonylcarbamoyladenylate synthase
CE453_RS21410	COG0583	DNA-binding transcription factor activity
CE453_RS21415	COG0604	alcohol dehydrogenase
CE453_RS21440	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CE453_RS21445	COG0513	Belongs to the DEAD box helicase family
CE453_RS21450	COG1278	Cold shock
CE453_RS21455	COG3791	Glutathione-dependent formaldehyde-activating
CE453_RS21465	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CE453_RS21470	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CE453_RS21470	COG0574	Belongs to the PEP-utilizing enzyme family
CE453_RS21475	COG2983	Belongs to the UPF0260 family
CE453_RS21480	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CE453_RS21525	COG2205	protein histidine kinase activity
CE453_RS21535	COG2166	iron-sulfur cluster assembly
CE453_RS21550	COG4957	zinc ion binding
CE453_RS21565	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CE453_RS21580	COG0463	Glycosyl transferase, family 2
CE453_RS21585	COG0728	peptidoglycan biosynthetic process
CE453_RS21595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CE453_RS21610	COG0736	holo-[acyl-carrier-protein] synthase activity
CE453_RS21615	COG0861	Integral membrane protein TerC family
CE453_RS21620	COG0861	Integral membrane protein TerC family
CE453_RS21625	COG0473	3-isopropylmalate dehydrogenase activity
CE453_RS21630	COG0596	Alpha beta hydrolase
CE453_RS21635	COG0072	phenylalanine-tRNA ligase activity
CE453_RS21635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CE453_RS21645	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CE453_RS21650	COG1611	Belongs to the LOG family
CE453_RS21655	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CE453_RS21660	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CE453_RS21670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE453_RS21680	COG1309	transcriptional regulator
CE453_RS21685	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CE453_RS21715	COG1802	Transcriptional regulator
CE453_RS21725	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CE453_RS21775	COG2239	Acts as a magnesium transporter
CE453_RS21780	COG0625	glutathione transferase activity
CE453_RS21820	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CE453_RS21845	COG0752	glycyl-tRNA synthetase alpha subunit
CE453_RS21870	COG0142	geranyltranstransferase activity
CE453_RS21875	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CE453_RS21890	COG1573	uracil-dna glycosylase
CE453_RS21895	COG2321	neutral zinc metallopeptidase
CE453_RS21900	COG2226	methyltransferase
CE453_RS21915	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CE453_RS21920	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CE453_RS21930	COG1194	a g-specific adenine glycosylase
CE453_RS21940	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CE453_RS21945	COG1196	nuclear chromosome segregation
CE453_RS21955	COG0356	it plays a direct role in the translocation of protons across the membrane
CE453_RS21960	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CE453_RS21965	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CE453_RS21970	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CE453_RS21980	COG2989	Protein conserved in bacteria
CE453_RS21985	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CE453_RS21990	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CE453_RS21995	COG0509	glycine decarboxylation via glycine cleavage system
CE453_RS22000	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CE453_RS22015	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CE453_RS22020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CE453_RS22025	COG0109	protoheme IX farnesyltransferase activity
CE453_RS22030	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CE453_RS22045	COG3346	SURF1 family
CE453_RS22055	COG0612	Peptidase, M16
CE453_RS22070	COG1678	Uncharacterized ACR, COG1678
CE453_RS22080	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CE453_RS22080	COG0678	peroxiredoxin activity
CE453_RS22090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CE453_RS22105	COG0328	RNA-DNA hybrid ribonuclease activity
CE453_RS22110	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CE453_RS22115	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CE453_RS22130	COG0475	glutathione-regulated potassium exporter activity
CE453_RS22130	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CE453_RS22145	COG0840	transmembrane signaling receptor activity
CE453_RS22155	COG0583	DNA-binding transcription factor activity
CE453_RS22180	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CE453_RS22190	COG0483	inositol monophosphate 1-phosphatase activity
CE453_RS22205	COG1519	Transferase
CE453_RS22210	COG1663	tetraacyldisaccharide 4'-kinase activity
CE453_RS22220	COG1073	alpha beta
CE453_RS22225	COG1570	exodeoxyribonuclease VII activity
CE453_RS22230	COG0151	Belongs to the GarS family
CE453_RS22235	COG0596	Alpha beta hydrolase
CE453_RS22240	COG1752	Esterase of the alpha-beta hydrolase superfamily
CE453_RS22245	COG0640	Transcriptional regulator
CE453_RS22260	COG0590	tRNA wobble adenosine to inosine editing
CE453_RS22265	COG1187	pseudouridine synthase activity
CE453_RS22270	COG0742	ribosomal rna small subunit methyltransferase
CE453_RS22285	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CE453_RS22290	COG0612	Peptidase, M16
CE453_RS22295	COG0612	Peptidase, M16
CE453_RS22305	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CE453_RS22310	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CE453_RS22315	COG0196	riboflavin kinase activity
CE453_RS22320	COG2030	dehydratase
CE453_RS22325	COG0745	RESPONSE REGULATOR receiver
CE453_RS22345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CE453_RS22350	COG0242	peptide deformylase activity
CE453_RS22355	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS22365	COG1250	3-hydroxyacyl-CoA dehydrogenase
CE453_RS22365	COG1024	Enoyl-CoA hydratase
CE453_RS22370	COG0183	Belongs to the thiolase family
CE453_RS22380	COG1960	acyl-CoA dehydrogenase activity
CE453_RS22395	COG0730	response to heat
CE453_RS22405	COG0303	'Molybdopterin
CE453_RS22410	COG0425	Belongs to the sulfur carrier protein TusA family
CE453_RS22415	COG0489	protein tyrosine kinase activity
CE453_RS22425	COG0746	molybdenum cofactor guanylyltransferase activity
CE453_RS22430	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CE453_RS22430	COG1618	nucleotide phosphatase activity, acting on free nucleotides
CE453_RS22450	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CE453_RS22465	COG1473	amidohydrolase
CE453_RS22470	COG0579	oxidoreductase
CE453_RS22475	COG0800	Aldolase
CE453_RS22485	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CE453_RS22495	COG2308	Evidence 4 Homologs of previously reported genes of
CE453_RS22495	COG2307	Protein conserved in bacteria
CE453_RS22510	COG1012	belongs to the aldehyde dehydrogenase family
CE453_RS22520	COG0671	phosphoesterase, PA-phosphatase related
CE453_RS22525	COG1597	lipid kinase activity
CE453_RS22545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CE453_RS22555	COG1228	amidohydrolase
CE453_RS22560	COG2986	histidine ammonia-lyase
CE453_RS22570	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CE453_RS22580	COG0372	Belongs to the citrate synthase family
CE453_RS22585	COG0372	Belongs to the citrate synthase family
CE453_RS22590	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CE453_RS22600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CE453_RS22615	COG0028	Belongs to the TPP enzyme family
CE453_RS22635	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CE453_RS22665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE453_RS22675	COG0747	negative chemotaxis
CE453_RS22680	COG1228	amidohydrolase
CE453_RS22700	COG0181	hydroxymethylbilane synthase activity
CE453_RS22705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CE453_RS22710	COG0697	spore germination
CE453_RS22725	COG0287	Prephenate dehydrogenase
CE453_RS22730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CE453_RS22740	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CE453_RS22745	COG2813	Specifically methylates the guanine in position
CE453_RS22745	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CE453_RS22750	COG0542	response to heat
CE453_RS22770	COG2890	protein-(glutamine-N5) methyltransferase activity
CE453_RS22775	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CE453_RS22780	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
CE453_RS22785	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CE453_RS22790	COG1877	trehalose-phosphatase activity
CE453_RS22795	COG3387	PFAM Glycoside hydrolase 15-related
CE453_RS22825	COG1280	lysine exporter protein (LysE YggA)
CE453_RS22845	COG0583	DNA-binding transcription factor activity
CE453_RS22850	COG1012	belongs to the aldehyde dehydrogenase family
CE453_RS22855	COG1960	acyl-CoA dehydrogenase activity
CE453_RS22860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CE453_RS22865	COG0028	Belongs to the TPP enzyme family
CE453_RS22890	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS22895	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CE453_RS22900	COG1840	ABC-type Fe3 transport system, periplasmic component
CE453_RS22925	COG1960	acyl-CoA dehydrogenase activity
CE453_RS22935	COG2816	NAD+ diphosphatase activity
CE453_RS22940	COG0154	amidase activity
CE453_RS22960	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CE453_RS22970	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CE453_RS22975	COG3474	cytochrome
CE453_RS22980	COG4166	transmembrane transport
CE453_RS22985	COG4174	ABC transporter (Permease)
CE453_RS22990	COG4239	(ABC) transporter, permease
CE453_RS22995	COG4172	Belongs to the ABC transporter superfamily
CE453_RS23030	COG5328	Belongs to the UPF0262 family
CE453_RS23035	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CE453_RS23045	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CE453_RS23060	COG3300	MHYT domain
CE453_RS23060	COG5001	Diguanylate cyclase
CE453_RS23070	COG5000	phosphorelay sensor kinase activity
CE453_RS23085	COG0167	dihydroorotate dehydrogenase activity
CE453_RS23100	COG1793	dna ligase
CE453_RS23105	COG2755	lipolytic protein G-D-S-L family
CE453_RS23125	COG1201	RNA secondary structure unwinding
CE453_RS23160	COG0473	3-isopropylmalate dehydrogenase activity
CE453_RS23180	COG3842	ATPase activity
CE453_RS23195	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CE453_RS23210	COG1088	dTDP-glucose 4,6-dehydratase activity
CE453_RS23230	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CE453_RS23260	COG0028	Belongs to the TPP enzyme family
CE453_RS23265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CE453_RS23280	COG0765	amino acid transport
CE453_RS23290	COG0583	DNA-binding transcription factor activity
CE453_RS23305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CE453_RS23310	COG2222	sugar isomerase
CE453_RS23330	COG0251	oxidation-reduction process
CE453_RS23335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CE453_RS23355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE453_RS23365	COG0601	transmembrane transport
CE453_RS23370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE453_RS23400	COG0438	transferase activity, transferring glycosyl groups
CE453_RS23415	COG0438	transferase activity, transferring glycosyl groups
CE453_RS23435	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CE453_RS23445	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CE453_RS23450	COG0367	asparagine synthase
CE453_RS23455	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CE453_RS23455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CE453_RS23480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CE453_RS23490	COG1088	dTDP-glucose 4,6-dehydratase activity
CE453_RS23495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CE453_RS23500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CE453_RS23515	COG0367	asparagine synthase
CE453_RS23545	COG4126	flavin adenine dinucleotide binding
CE453_RS23560	COG1414	Transcriptional regulator
CE453_RS23600	COG0284	orotidine-5'-phosphate decarboxylase activity
CE453_RS23605	COG0730	response to heat
CE453_RS23615	COG1509	lysine 2,3-aminomutase activity
CE453_RS23620	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CE453_RS23625	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CE453_RS23635	COG0519	Catalyzes the synthesis of GMP from XMP
CE453_RS23640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CE453_RS23655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE453_RS23660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CE453_RS23665	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CE453_RS23670	COG1137	ATPase activity
CE453_RS23685	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CE453_RS23705	COG0101	tRNA pseudouridine synthase activity
CE453_RS23710	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CE453_RS23715	COG0242	peptide deformylase activity
CE453_RS23730	COG1116	anion transmembrane transporter activity
CE453_RS23735	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CE453_RS23740	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CE453_RS23775	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CE453_RS23790	COG2423	ornithine cyclodeaminase activity
CE453_RS23800	COG0776	regulation of translation
CE453_RS23805	COG0616	signal peptide processing
CE453_RS23810	COG0443	Heat shock 70 kDa protein
CE453_RS23815	COG0539	negative regulation of cytoplasmic translation
CE453_RS23820	COG1704	LemA family
CE453_RS23825	COG0501	Belongs to the peptidase M48B family
CE453_RS23840	COG0137	argininosuccinate synthase activity
CE453_RS23860	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CE453_RS23870	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CE453_RS23880	COG0735	belongs to the Fur family
CE453_RS23885	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CE453_RS23920	COG1760	l-serine dehydratase
CE453_RS23930	COG0745	RESPONSE REGULATOR receiver
CE453_RS23935	COG2205	protein histidine kinase activity
CE453_RS23945	COG2186	Transcriptional regulator
CE453_RS23955	COG3395	kinase activity
CE453_RS23960	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CE453_RS23965	COG1454	alcohol dehydrogenase
CE453_RS23975	COG1116	anion transmembrane transporter activity
CE453_RS23980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CE453_RS24000	COG0444	Belongs to the ABC transporter superfamily
CE453_RS24005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CE453_RS24020	COG0747	negative chemotaxis
CE453_RS24025	COG2186	Transcriptional regulator
CE453_RS24040	COG1940	carbohydrate kinase activity
CE453_RS24040	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CE453_RS24050	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CE453_RS24065	COG0747	negative chemotaxis
CE453_RS24070	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CE453_RS24095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CE453_RS24105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CE453_RS24120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CE453_RS24130	COG0601	transmembrane transport
CE453_RS24135	COG0747	negative chemotaxis
CE453_RS24145	COG0747	negative chemotaxis
CE453_RS24175	COG1473	amidohydrolase
CE453_RS24180	COG0154	amidase activity
CE453_RS24185	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS24190	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS24200	COG1177	transmembrane transport
CE453_RS24205	COG1176	ABC-type spermidine putrescine transport system, permease component I
CE453_RS24210	COG3842	ATPase activity
CE453_RS24235	COG1473	amidohydrolase
CE453_RS24240	COG0747	negative chemotaxis
CE453_RS24245	COG0601	transmembrane transport
CE453_RS24250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE453_RS24255	COG0444	Belongs to the ABC transporter superfamily
CE453_RS24260	COG4608	Belongs to the ABC transporter superfamily
CE453_RS24275	COG0583	DNA-binding transcription factor activity
CE453_RS24280	COG0454	-acetyltransferase
CE453_RS24280	COG0456	acetyltransferase
CE453_RS24285	COG4948	Mandelate Racemase Muconate Lactonizing
CE453_RS24290	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CE453_RS24295	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CE453_RS24300	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CE453_RS24305	COG2186	Transcriptional regulator
CE453_RS24310	COG4948	Mandelate Racemase Muconate Lactonizing
CE453_RS24315	COG1802	Transcriptional regulator
CE453_RS24320	COG0657	acetylesterase activity
CE453_RS24330	COG1175	transmembrane transport
CE453_RS24335	COG0395	ABC-type sugar transport system, permease component
CE453_RS24350	COG2890	protein-(glutamine-N5) methyltransferase activity
CE453_RS24360	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CE453_RS24365	COG0318	PFAM AMP-dependent synthetase and ligase
CE453_RS24375	COG0367	asparagine synthase
CE453_RS24380	COG0642	Histidine kinase
CE453_RS24400	COG1376	ErfK ybiS ycfS ynhG family protein
CE453_RS24400	COG1388	LysM domain
CE453_RS24405	COG2010	Cytochrome c
CE453_RS24405	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CE453_RS24410	COG2080	2 iron, 2 sulfur cluster binding
CE453_RS24415	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CE453_RS24415	COG2010	Cytochrome c
CE453_RS24425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CE453_RS24430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CE453_RS24435	COG3938	Belongs to the proline racemase family
CE453_RS24450	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
CE453_RS24460	COG1960	acyl-CoA dehydrogenase activity
CE453_RS24470	COG2807	transmembrane transport
CE453_RS24475	COG0590	tRNA wobble adenosine to inosine editing
CE453_RS24490	COG0747	negative chemotaxis
CE453_RS24495	COG0601	transmembrane transport
CE453_RS24510	COG0179	Fumarylacetoacetate (FAA) hydrolase
CE453_RS24515	COG3971	2-oxopent-4-enoate hydratase activity
CE453_RS24520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE453_RS24525	COG4597	amino acid ABC transporter
CE453_RS24530	COG0765	amino acid transport
CE453_RS24535	COG1126	abc transporter atp-binding protein
CE453_RS24540	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CE453_RS24550	COG1846	Transcriptional regulator
CE453_RS24555	COG1280	lysine exporter protein (LysE YggA)
CE453_RS24565	COG2226	methyltransferase
CE453_RS24605	COG3842	ATPase activity
CE453_RS24630	COG2010	Cytochrome c
CE453_RS24660	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CE453_RS24670	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CE453_RS24675	COG3608	succinylglutamate desuccinylase aspartoacylase
CE453_RS24675	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CE453_RS24700	COG0765	amino acid transport
CE453_RS24705	COG0765	amino acid transport
CE453_RS24710	COG1126	abc transporter atp-binding protein
CE453_RS24720	COG0583	DNA-binding transcription factor activity
CE453_RS24730	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CE453_RS24740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CE453_RS24750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CE453_RS24760	COG4948	Mandelate Racemase Muconate Lactonizing
CE453_RS24790	COG1802	Transcriptional regulator
CE453_RS24795	COG4948	Mandelate Racemase Muconate Lactonizing
CE453_RS24830	COG1215	transferase activity, transferring glycosyl groups
CE453_RS24845	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CE453_RS24865	COG4191	Histidine kinase
CE453_RS24875	COG0559	Belongs to the binding-protein-dependent transport system permease family
CE453_RS24885	COG1129	ABC transporter
CE453_RS24920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE453_RS24925	COG0601	transmembrane transport
CE453_RS24935	COG1917	Cupin 2, conserved barrel domain protein
CE453_RS24935	COG1396	sequence-specific DNA binding
CE453_RS24945	COG4608	Belongs to the ABC transporter superfamily
CE453_RS24950	COG0444	Belongs to the ABC transporter superfamily
CE453_RS24955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE453_RS24960	COG0601	transmembrane transport
CE453_RS24965	COG0747	negative chemotaxis
CE453_RS24970	COG0747	negative chemotaxis
CE453_RS24975	COG2204	response regulator
CE453_RS24980	COG4191	Histidine kinase
CE453_RS24985	COG1301	dicarboxylic acid transport
CE453_RS25005	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS25020	COG0395	ABC-type sugar transport system, permease component
CE453_RS25025	COG1175	transmembrane transport
CE453_RS25035	COG1609	Transcriptional regulator
CE453_RS25050	COG0601	transmembrane transport
CE453_RS25055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE453_RS25060	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS25120	COG0277	FAD linked oxidase domain protein
CE453_RS25125	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CE453_RS25130	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CE453_RS25170	COG0306	phosphate transporter
CE453_RS25175	COG1392	Phosphate transport regulator
CE453_RS25185	COG1376	ErfK ybiS ycfS ynhG family protein
CE453_RS25210	COG1573	uracil-dna glycosylase
CE453_RS25260	COG0583	DNA-binding transcription factor activity
CE453_RS25265	COG0129	dihydroxy-acid dehydratase activity
CE453_RS25315	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CE453_RS25330	COG2205	protein histidine kinase activity
CE453_RS25330	COG5002	protein histidine kinase activity
CE453_RS25330	COG0784	Response regulator, receiver
CE453_RS25335	COG0606	chelatase, subunit chli
CE453_RS25340	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CE453_RS25355	COG0582	viral genome integration into host DNA
CE453_RS25410	COG2255	four-way junction helicase activity
CE453_RS25460	COG1061	Type III restriction enzyme res subunit
CE453_RS25520	COG2369	cell adhesion
CE453_RS25775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE453_RS25780	COG1376	ErfK ybiS ycfS ynhG family protein
CE453_RS25805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CE453_RS25810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE453_RS25815	COG0601	transmembrane transport
CE453_RS25840	COG0765	amino acid transport
CE453_RS25850	COG2084	Dehydrogenase
CE453_RS25855	COG2186	Transcriptional regulator
CE453_RS25875	COG2211	Major facilitator Superfamily
CE453_RS25885	COG1609	Transcriptional regulator
CE453_RS25895	COG1177	transmembrane transport
CE453_RS25910	COG3842	ATPase activity
CE453_RS25935	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CE453_RS25935	COG2010	Cytochrome c
CE453_RS25940	COG1522	sequence-specific DNA binding
CE453_RS25955	COG2814	Major facilitator Superfamily
CE453_RS25960	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CE453_RS26330	COG0592	DNA-directed DNA polymerase activity
CE453_RS26365	COG1061	Type III restriction enzyme res subunit
CE453_RS26370	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CE453_RS26450	COG2259	Doxx family
CE453_RS26465	COG1074	ATP-dependent DNA helicase activity
CE453_RS26470	COG2887	Belongs to the helicase family. UvrD subfamily
CE453_RS26475	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CE453_RS26480	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CE453_RS26485	COG2205	protein histidine kinase activity
CE453_RS26490	COG3178	'Phosphotransferase
CE453_RS26495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE453_RS26500	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE453_RS26510	COG0642	Histidine kinase
CE453_RS26515	COG0745	RESPONSE REGULATOR receiver
CE453_RS26525	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CE453_RS26540	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CE453_RS26560	COG1012	belongs to the aldehyde dehydrogenase family
CE453_RS26590	COG0673	inositol 2-dehydrogenase activity
CE453_RS26595	COG0405	Gamma-glutamyltransferase
CE453_RS26605	COG0523	cobalamin synthesis protein
CE453_RS26625	COG0667	Aldo Keto reductase
CE453_RS26630	COG1522	sequence-specific DNA binding
CE453_RS26635	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS26640	COG4948	Mandelate Racemase Muconate Lactonizing
CE453_RS26655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE453_RS26660	COG0765	amino acid transport
CE453_RS26665	COG0765	amino acid transport
CE453_RS26680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CE453_RS26720	COG0583	DNA-binding transcription factor activity
CE453_RS26735	COG3383	formate dehydrogenase (NAD+) activity
CE453_RS26740	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CE453_RS26750	COG2223	nitrite transmembrane transporter activity
CE453_RS26760	COG1764	response to oxidative stress
CE453_RS26765	COG4608	Belongs to the ABC transporter superfamily
CE453_RS26770	COG0444	Belongs to the ABC transporter superfamily
CE453_RS26775	COG0402	S-adenosylhomocysteine deaminase activity
CE453_RS26785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE453_RS26790	COG0601	transmembrane transport
CE453_RS26795	COG4533	DNA binding
CE453_RS26800	COG1802	Transcriptional regulator
CE453_RS26805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CE453_RS26810	COG2267	carboxylic ester hydrolase activity
CE453_RS26840	COG0556	nucleotide-excision repair
CE453_RS26855	COG1742	UPF0060 membrane protein
CE453_RS26860	COG1283	sodium-dependent phosphate transmembrane transporter activity
CE453_RS26865	COG3842	ATPase activity
CE453_RS26875	COG1840	ABC-type Fe3 transport system, periplasmic component
CE453_RS26880	COG0483	inositol monophosphate 1-phosphatase activity
CE453_RS26885	COG0673	inositol 2-dehydrogenase activity
CE453_RS26905	COG0601	transmembrane transport
CE453_RS26910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE453_RS26925	COG2188	Transcriptional regulator
CE453_RS26950	COG4303	Ethanolamine ammonia lyase large subunit
CE453_RS26985	COG1960	acyl-CoA dehydrogenase activity
CE453_RS27025	COG1215	transferase activity, transferring glycosyl groups
CE453_RS27050	COG1596	polysaccharide export
CE453_RS27055	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CE453_RS27155	COG2875	Belongs to the precorrin methyltransferase family
CE453_RS27160	COG1797	cobyrinic acid a,c-diamide synthase activity
CE453_RS27165	COG0778	Nitroreductase
CE453_RS27210	COG0559	Belongs to the binding-protein-dependent transport system permease family
CE453_RS27230	COG0477	Major facilitator Superfamily
CE453_RS27240	COG2171	N-acyltransferase activity
CE453_RS27260	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CE453_RS27270	COG0747	negative chemotaxis
CE453_RS27280	COG1473	amidohydrolase
CE453_RS27310	COG2814	Major facilitator Superfamily
CE453_RS27325	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CE453_RS27330	COG0069	glutamate synthase activity
CE453_RS27335	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS27345	COG0481	GTPase activity
CE453_RS27365	COG1420	regulation of RNA biosynthetic process
CE453_RS27370	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CE453_RS27375	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CE453_RS27380	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CE453_RS27385	COG3842	ATPase activity
CE453_RS27390	COG0395	ABC-type sugar transport system, permease component
CE453_RS27425	COG2226	methyltransferase
CE453_RS27435	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CE453_RS27440	COG4213	ABC transporter substrate-binding protein
CE453_RS27445	COG4214	carbohydrate transport
CE453_RS27465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CE453_RS27475	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CE453_RS27490	COG1079	Belongs to the binding-protein-dependent transport system permease family
CE453_RS27495	COG1079	Belongs to the binding-protein-dependent transport system permease family
CE453_RS27500	COG3845	ABC transporter
CE453_RS27505	COG1744	ABC transporter substrate-binding protein PnrA-like
CE453_RS27510	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CE453_RS27515	COG0189	ligase activity
CE453_RS27520	COG0792	nuclease activity
CE453_RS27525	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CE453_RS27535	COG4232	protein-disulfide reductase activity
CE453_RS27540	COG1116	anion transmembrane transporter activity
CE453_RS27545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CE453_RS27555	COG1522	sequence-specific DNA binding
CE453_RS27560	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CE453_RS27565	COG0756	dUTP diphosphatase activity
CE453_RS27580	COG1309	transcriptional regulator
CE453_RS27595	COG3842	ATPase activity
CE453_RS27605	COG1176	ABC-type spermidine putrescine transport system, permease component I
CE453_RS27635	COG1476	TRANSCRIPTIONal
CE453_RS27645	COG0756	dUTP diphosphatase activity
CE453_RS27650	COG1959	2 iron, 2 sulfur cluster binding
CE453_RS27665	COG2514	catechol 2,3-dioxygenase activity
CE453_RS27670	COG1295	ribonuclease BN
CE453_RS27680	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CE453_RS27685	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CE453_RS27715	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CE453_RS27720	COG0594	ribonuclease P activity
CE453_RS27725	COG0706	membrane insertase activity
CE453_RS27730	COG0110	maltose O-acetyltransferase activity
CE453_RS27735	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CE453_RS27745	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CE453_RS27760	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CE453_RS27785	COG1028	Short-chain dehydrogenase reductase Sdr
CE453_RS27810	COG1402	creatininase
CE453_RS27815	COG0601	transmembrane transport
CE453_RS27820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE453_RS27830	COG0726	polysaccharide deacetylase
CE453_RS27850	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CE453_RS27855	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CE453_RS27865	COG0443	Heat shock 70 kDa protein
CE453_RS27870	COG0484	heat shock protein binding
CE453_RS27875	COG3237	CsbD-like
CE453_RS27895	COG1464	Belongs to the NlpA lipoprotein family
CE453_RS27900	COG2011	ABC-type metal ion transport system permease component
CE453_RS27905	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CE453_RS27940	COG1278	Cold shock
CE453_RS27955	COG0392	lysyltransferase activity
CE453_RS27965	COG0281	malic enzyme
CE453_RS27965	COG0280	phosphate acetyltransferase
CE453_RS27970	COG0840	transmembrane signaling receptor activity
CE453_RS27975	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CE453_RS27980	COG0131	Imidazoleglycerol-phosphate dehydratase
CE453_RS27995	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CE453_RS28005	COG0107	imidazoleglycerol-phosphate synthase activity
CE453_RS28010	COG0140	phosphoribosyl-ATP diphosphatase activity
CE453_RS28015	COG1072	(Pantothenic acid kinase))
CE453_RS28020	COG1238	metal cluster binding
CE453_RS28025	COG0251	oxidation-reduction process
CE453_RS28040	COG1492	cobalamin metabolic process
CE453_RS28050	COG1086	Polysaccharide biosynthesis protein
CE453_RS28060	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CE453_RS28070	COG2204	response regulator
CE453_RS28075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE453_RS28080	COG0745	RESPONSE REGULATOR receiver
CE453_RS28085	COG2205	protein histidine kinase activity
CE453_RS28090	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CE453_RS28095	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CE453_RS28100	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CE453_RS28115	COG2223	nitrite transmembrane transporter activity
CE453_RS28130	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CE453_RS28135	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CE453_RS28145	COG1643	Atp-dependent helicase
CE453_RS28150	COG0159	tryptophan synthase activity
CE453_RS28155	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CE453_RS28160	COG0285	dihydrofolate synthase activity
CE453_RS28170	COG0656	L-ascorbic acid biosynthetic process
CE453_RS28190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CE453_RS28230	COG4964	Belongs to the GSP D family
CE453_RS28240	COG1192	Involved in chromosome partitioning
CE453_RS28265	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CE453_RS28275	COG0791	NLP P60 protein
CE453_RS28280	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CE453_RS28285	COG2226	methyltransferase
CE453_RS28290	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CE453_RS28295	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CE453_RS28305	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CE453_RS28310	COG1360	Flagellar Motor Protein
CE453_RS28325	COG1024	Enoyl-CoA hydratase
CE453_RS28335	COG0268	Binds directly to 16S ribosomal RNA