locus-tag	class	description
DWV08_RS00005	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DWV08_RS00010	COG3421	Type III restriction
DWV08_RS00015	COG2189	Belongs to the N(4) N(6)-methyltransferase family
DWV08_RS00035	COG1595	DNA-templated transcription, initiation
DWV08_RS00075	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DWV08_RS00085	COG0395	ABC-type sugar transport system, permease component
DWV08_RS00090	COG1175	transmembrane transport
DWV08_RS00095	COG0656	L-ascorbic acid biosynthetic process
DWV08_RS00105	COG1802	Transcriptional regulator
DWV08_RS00110	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DWV08_RS00115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWV08_RS00120	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWV08_RS00125	COG1120	ATPase activity
DWV08_RS00145	COG2323	membrane
DWV08_RS00165	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DWV08_RS00180	COG0800	Aldolase
DWV08_RS00250	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DWV08_RS00255	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DWV08_RS00265	COG1966	Carbon starvation protein
DWV08_RS00275	COG0003	Pfam Anion-transporting ATPase
DWV08_RS00280	COG2814	Major facilitator Superfamily
DWV08_RS00285	COG2197	response regulator
DWV08_RS00300	COG1349	DNA-binding transcription factor activity
DWV08_RS00305	COG1609	Transcriptional regulator
DWV08_RS00320	COG1309	transcriptional regulator
DWV08_RS00325	COG3876	Protein conserved in bacteria
DWV08_RS00330	COG1472	Belongs to the glycosyl hydrolase 3 family
DWV08_RS00350	COG0831	urea catabolic process
DWV08_RS00360	COG0804	urea catabolic process
DWV08_RS00370	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DWV08_RS00375	COG0829	nickel cation binding
DWV08_RS00380	COG0667	Aldo Keto reductase
DWV08_RS00395	COG1074	ATP-dependent DNA helicase activity
DWV08_RS00410	COG2066	Belongs to the glutaminase family
DWV08_RS00425	COG0386	Belongs to the glutathione peroxidase family
DWV08_RS00440	COG0590	tRNA wobble adenosine to inosine editing
DWV08_RS00455	COG1902	pentaerythritol trinitrate reductase activity
DWV08_RS00455	COG0446	pyridine nucleotide-disulphide oxidoreductase
DWV08_RS00480	COG0454	-acetyltransferase
DWV08_RS00480	COG0456	acetyltransferase
DWV08_RS00495	COG3642	lipopolysaccharide core region biosynthetic process
DWV08_RS00515	COG1574	metal-dependent hydrolase with the TIM-barrel fold
DWV08_RS00520	COG1131	(ABC) transporter
DWV08_RS00530	COG4585	Histidine kinase
DWV08_RS00535	COG2197	response regulator
DWV08_RS00545	COG1132	(ABC) transporter
DWV08_RS00570	COG2084	Dehydrogenase
DWV08_RS00590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DWV08_RS00600	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DWV08_RS00615	COG0018	arginyl-trna synthetase
DWV08_RS00630	COG0657	acetylesterase activity
DWV08_RS00660	COG1120	ATPase activity
DWV08_RS00665	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DWV08_RS00700	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
DWV08_RS00710	COG0277	FAD linked oxidase domain protein
DWV08_RS00715	COG2066	Belongs to the glutaminase family
DWV08_RS00750	COG0077	Prephenate dehydratase
DWV08_RS00770	COG1597	lipid kinase activity
DWV08_RS00775	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DWV08_RS00780	COG0561	phosphatase activity
DWV08_RS00785	COG0604	alcohol dehydrogenase
DWV08_RS00790	COG0604	alcohol dehydrogenase
DWV08_RS00795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DWV08_RS00800	COG1131	(ABC) transporter
DWV08_RS00820	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DWV08_RS00830	COG0246	Mannitol dehydrogenase
DWV08_RS00835	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWV08_RS00835	COG2213	PTS system mannitol-specific
DWV08_RS00840	COG0398	Pfam SNARE associated Golgi protein
DWV08_RS00850	COG1846	Transcriptional regulator
DWV08_RS00855	COG0697	spore germination
DWV08_RS00865	COG1278	Cold shock
DWV08_RS00875	COG3655	Transcriptional regulator
DWV08_RS00895	COG1268	BioY protein
DWV08_RS00920	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DWV08_RS00945	COG0765	amino acid transport
DWV08_RS00950	COG0765	amino acid transport
DWV08_RS00955	COG1126	abc transporter atp-binding protein
DWV08_RS00960	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DWV08_RS00980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DWV08_RS01000	COG0306	phosphate transporter
DWV08_RS01025	COG1940	carbohydrate kinase activity
DWV08_RS01025	COG1846	Transcriptional regulator
DWV08_RS01035	COG0395	ABC-type sugar transport system, permease component
DWV08_RS01040	COG4209	transmembrane transport
DWV08_RS01065	COG1764	response to oxidative stress
DWV08_RS01095	COG0515	serine threonine protein kinase
DWV08_RS01095	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DWV08_RS01120	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DWV08_RS01135	COG0459	protein refolding
DWV08_RS01160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWV08_RS01165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWV08_RS01190	COG0747	negative chemotaxis
DWV08_RS01195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DWV08_RS01200	COG0277	FAD linked oxidase domain protein
DWV08_RS01205	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DWV08_RS01210	COG0640	Transcriptional regulator
DWV08_RS01215	COG0318	PFAM AMP-dependent synthetase and ligase
DWV08_RS01225	COG0513	Belongs to the DEAD box helicase family
DWV08_RS01245	COG0328	RNA-DNA hybrid ribonuclease activity
DWV08_RS01255	COG2188	Transcriptional regulator
DWV08_RS01260	COG1125	glycine betaine transport
DWV08_RS01280	COG2311	Membrane
DWV08_RS01290	COG2205	protein histidine kinase activity
DWV08_RS01295	COG0745	RESPONSE REGULATOR receiver
DWV08_RS01300	COG5416	Lipopolysaccharide assembly protein A domain
DWV08_RS01310	COG5473	translation initiation factor activity
DWV08_RS01315	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DWV08_RS01335	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DWV08_RS01340	COG1940	carbohydrate kinase activity
DWV08_RS01345	COG2814	Major facilitator Superfamily
DWV08_RS01350	COG0626	cystathionine gamma-synthase activity
DWV08_RS01360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DWV08_RS01375	COG0351	phosphomethylpyrimidine kinase
DWV08_RS01385	COG1505	serine-type exopeptidase activity
DWV08_RS01410	COG1404	Belongs to the peptidase S8 family
DWV08_RS01425	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
DWV08_RS01430	COG1940	carbohydrate kinase activity
DWV08_RS01435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DWV08_RS01450	COG0601	transmembrane transport
DWV08_RS01455	COG0747	negative chemotaxis
DWV08_RS01460	COG2186	Transcriptional regulator
DWV08_RS01470	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DWV08_RS01485	COG0714	Associated with various cellular activities
DWV08_RS01505	COG3321	synthase
DWV08_RS01505	COG0604	alcohol dehydrogenase
DWV08_RS01505	COG1028	Short-chain dehydrogenase reductase Sdr
DWV08_RS01550	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DWV08_RS01560	COG0315	cyclic pyranopterin monophosphate synthase activity
DWV08_RS01565	COG0315	cyclic pyranopterin monophosphate synthase activity
DWV08_RS01565	COG0521	Mo-molybdopterin cofactor biosynthetic process
DWV08_RS01575	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DWV08_RS01580	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DWV08_RS01585	COG0459	protein refolding
DWV08_RS01625	COG0516	GMP reductase activity
DWV08_RS01645	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DWV08_RS01665	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DWV08_RS01665	COG0519	Catalyzes the synthesis of GMP from XMP
DWV08_RS01675	COG0477	Major facilitator Superfamily
DWV08_RS01690	COG0433	COG0433 Predicted ATPase
DWV08_RS01695	COG0588	phosphoglycerate mutase activity
DWV08_RS01705	COG1490	D-aminoacyl-tRNA deacylase activity
DWV08_RS01720	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DWV08_RS01730	COG3142	Participates in the control of copper homeostasis
DWV08_RS01740	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DWV08_RS01785	COG0346	lactoylglutathione lyase activity
DWV08_RS01805	COG0045	succinate-CoA ligase (ADP-forming) activity
DWV08_RS01830	COG1321	iron dependent repressor
DWV08_RS01850	COG2226	methyltransferase
DWV08_RS01855	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DWV08_RS01865	COG1316	TRANSCRIPTIONal
DWV08_RS01885	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DWV08_RS01895	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DWV08_RS01895	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DWV08_RS01905	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DWV08_RS01910	COG1329	Transcriptional regulator
DWV08_RS01920	COG0745	RESPONSE REGULATOR receiver
DWV08_RS01925	COG5002	protein histidine kinase activity
DWV08_RS01940	COG1316	TRANSCRIPTIONal
DWV08_RS01945	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DWV08_RS01985	COG4133	protoheme IX ABC transporter activity
DWV08_RS01995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DWV08_RS02020	COG0544	peptidyl-prolyl cis-trans isomerase activity
DWV08_RS02030	COG0791	NLP P60 protein
DWV08_RS02030	COG3103	Sh3 type 3 domain protein
DWV08_RS02030	COG1388	LysM domain
DWV08_RS02035	COG0740	serine-type endopeptidase activity
DWV08_RS02040	COG0740	serine-type endopeptidase activity
DWV08_RS02045	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DWV08_RS02050	COG0287	Prephenate dehydrogenase
DWV08_RS02050	COG1605	Chorismate mutase
DWV08_RS02060	COG0243	molybdopterin cofactor binding
DWV08_RS02060	COG3383	formate dehydrogenase (NAD+) activity
DWV08_RS02065	COG0437	4 iron, 4 sulfur cluster binding
DWV08_RS02075	COG0709	Synthesizes selenophosphate from selenide and ATP
DWV08_RS02085	COG1921	L-seryl-tRNASec selenium transferase activity
DWV08_RS02095	COG0525	valine-tRNA ligase activity
DWV08_RS02100	COG0095	Lipoate-protein ligase
DWV08_RS02110	COG4555	ABC transporter
DWV08_RS02125	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
DWV08_RS02135	COG1132	(ABC) transporter
DWV08_RS02155	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DWV08_RS02180	COG0285	dihydrofolate synthase activity
DWV08_RS02190	COG0105	UTP biosynthetic process
DWV08_RS02210	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DWV08_RS02245	COG0228	four-way junction DNA binding
DWV08_RS02250	COG1837	Belongs to the UPF0109 family
DWV08_RS02260	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DWV08_RS02265	COG0336	Belongs to the RNA methyltransferase TrmD family
DWV08_RS02270	COG0335	large ribosomal subunit rRNA binding
DWV08_RS02275	COG0681	Belongs to the peptidase S26 family
DWV08_RS02280	COG0681	Belongs to the peptidase S26 family
DWV08_RS02285	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DWV08_RS02295	COG0792	nuclease activity
DWV08_RS02310	COG4974	Belongs to the 'phage' integrase family
DWV08_RS02330	COG0052	Belongs to the universal ribosomal protein uS2 family
DWV08_RS02335	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DWV08_RS02340	COG0528	UMP kinase activity
DWV08_RS02345	COG0233	cytoplasmic translational termination
DWV08_RS02370	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DWV08_RS02375	COG0750	zinc metalloprotease
DWV08_RS02380	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DWV08_RS02395	COG0442	prolyl-tRNA aminoacylation
DWV08_RS02405	COG0779	Required for maturation of 30S ribosomal subunits
DWV08_RS02420	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DWV08_RS02420	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DWV08_RS02430	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DWV08_RS02435	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DWV08_RS02450	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DWV08_RS02455	COG1185	polyribonucleotide nucleotidyltransferase activity
DWV08_RS02470	COG0612	Peptidase, M16
DWV08_RS02475	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DWV08_RS02495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DWV08_RS02500	COG0367	asparagine synthase
DWV08_RS02505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DWV08_RS02510	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DWV08_RS02515	COG1674	ftsk spoiiie
DWV08_RS02525	COG1058	Belongs to the CinA family
DWV08_RS02525	COG1546	Belongs to the CinA family
DWV08_RS02540	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DWV08_RS02550	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DWV08_RS02560	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DWV08_RS02565	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DWV08_RS02575	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DWV08_RS02585	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DWV08_RS02590	COG1388	LysM domain
DWV08_RS02595	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DWV08_RS02610	COG1278	Cold shock
DWV08_RS02625	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DWV08_RS02635	COG2001	Belongs to the MraZ family
DWV08_RS02640	COG0275	rRNA processing
DWV08_RS02655	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DWV08_RS02665	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DWV08_RS02670	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DWV08_RS02680	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DWV08_RS02690	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DWV08_RS02695	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DWV08_RS02700	COG1496	oxidoreductase activity
DWV08_RS02705	COG1799	cell septum assembly
DWV08_RS02720	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DWV08_RS02755	COG1175	transmembrane transport
DWV08_RS02760	COG0395	ABC-type sugar transport system, permease component
DWV08_RS02765	COG0587	DNA-directed DNA polymerase activity
DWV08_RS02790	COG0477	Major facilitator Superfamily
DWV08_RS02795	COG0166	Belongs to the GPI family
DWV08_RS02805	COG0601	transmembrane transport
DWV08_RS02810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWV08_RS02820	COG1217	gtp-binding protein TYPA
DWV08_RS02830	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DWV08_RS02855	COG1882	Formate acetyltransferase
DWV08_RS02875	COG2171	N-acyltransferase activity
DWV08_RS02900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DWV08_RS02905	COG1611	Belongs to the LOG family
DWV08_RS02925	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DWV08_RS02940	COG2239	Acts as a magnesium transporter
DWV08_RS02945	COG0006	proline dipeptidase activity
DWV08_RS02950	COG0613	PHP domain protein
DWV08_RS02955	COG0513	Belongs to the DEAD box helicase family
DWV08_RS02970	COG1309	transcriptional regulator
DWV08_RS03025	COG3480	Lon protease (S16) C-terminal proteolytic domain
DWV08_RS03050	COG1653	transport
DWV08_RS03055	COG1946	Acyl-CoA thioesterase
DWV08_RS03070	COG0668	transmembrane transport
DWV08_RS03085	COG0515	serine threonine protein kinase
DWV08_RS03095	COG1132	(ABC) transporter
DWV08_RS03105	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DWV08_RS03110	COG0698	ribose 5-phosphate isomerase
DWV08_RS03120	COG2267	carboxylic ester hydrolase activity
DWV08_RS03135	COG1122	ATPase activity
DWV08_RS03140	COG4721	ABC-type cobalt transport system, permease component
DWV08_RS03170	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DWV08_RS03175	COG0297	glycogen (starch) synthase activity
DWV08_RS03215	COG4585	Histidine kinase
DWV08_RS03220	COG2197	response regulator
DWV08_RS03225	COG1063	alcohol dehydrogenase
DWV08_RS03245	COG2226	methyltransferase
DWV08_RS03250	COG0129	dihydroxy-acid dehydratase activity
DWV08_RS03265	COG2079	MmgE PrpD family protein
DWV08_RS03285	COG2814	Major facilitator Superfamily
DWV08_RS03335	COG0745	RESPONSE REGULATOR receiver
DWV08_RS03340	COG2205	protein histidine kinase activity
DWV08_RS03345	COG1388	LysM domain
DWV08_RS03350	COG0443	Heat shock 70 kDa protein
DWV08_RS03355	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DWV08_RS03360	COG0484	heat shock protein binding
DWV08_RS03365	COG0789	Transcriptional regulator
DWV08_RS03375	COG0438	transferase activity, transferring glycosyl groups
DWV08_RS03380	COG1881	PFAM PEBP family protein
DWV08_RS03395	COG0366	Alpha amylase catalytic
DWV08_RS03405	COG1175	transmembrane transport
DWV08_RS03410	COG2182	Extracellular solute-binding protein
DWV08_RS03420	COG0180	Tryptophanyl-tRNA synthetase
DWV08_RS03430	COG1045	serine acetyltransferase
DWV08_RS03455	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DWV08_RS03460	COG0509	glycine decarboxylation via glycine cleavage system
DWV08_RS03465	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DWV08_RS03465	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DWV08_RS03480	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DWV08_RS03495	COG0009	L-threonylcarbamoyladenylate synthase
DWV08_RS03510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DWV08_RS03540	COG0495	leucyl-tRNA aminoacylation
DWV08_RS03550	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DWV08_RS03555	COG0513	Belongs to the DEAD box helicase family
DWV08_RS03560	COG1760	l-serine dehydratase
DWV08_RS03570	COG1902	pentaerythritol trinitrate reductase activity
DWV08_RS03575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DWV08_RS03585	COG2197	response regulator
DWV08_RS03605	COG0215	cysteine-tRNA ligase activity
DWV08_RS03610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DWV08_RS03625	COG3842	ATPase activity
DWV08_RS03630	COG0242	peptide deformylase activity
DWV08_RS03640	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DWV08_RS03645	COG2027	D-alanyl-D-alanine carboxypeptidase
DWV08_RS03650	COG0037	tRNA processing
DWV08_RS03655	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DWV08_RS03665	COG0302	gtp cyclohydrolase
DWV08_RS03670	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DWV08_RS03675	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DWV08_RS03675	COG0302	gtp cyclohydrolase
DWV08_RS03700	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DWV08_RS03705	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DWV08_RS03720	COG2017	converts alpha-aldose to the beta-anomer
DWV08_RS03725	COG1556	Lactate utilization protein
DWV08_RS03730	COG1139	Iron-sulfur cluster binding protein
DWV08_RS03735	COG0247	lactate metabolic process
DWV08_RS03740	COG0579	oxidoreductase
DWV08_RS03765	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DWV08_RS03775	COG1970	mechanosensitive ion channel activity
DWV08_RS03815	COG0483	inositol monophosphate 1-phosphatase activity
DWV08_RS03875	COG1733	regulation of RNA biosynthetic process
DWV08_RS03925	COG1335	isochorismatase
DWV08_RS03940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWV08_RS03945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DWV08_RS03950	COG0446	pyridine nucleotide-disulphide oxidoreductase
DWV08_RS03960	COG1937	Protein conserved in bacteria
DWV08_RS04010	COG0084	hydrolase, TatD family'
DWV08_RS04015	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DWV08_RS04020	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DWV08_RS04040	COG0488	(ABC) transporter
DWV08_RS04060	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DWV08_RS04080	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DWV08_RS04085	COG0193	aminoacyl-tRNA hydrolase activity
DWV08_RS04100	COG0148	phosphopyruvate hydratase activity
DWV08_RS04120	COG1252	NADH dehydrogenase
DWV08_RS04125	COG0363	glucosamine-6-phosphate deaminase activity
DWV08_RS04130	COG2252	PERMEase
DWV08_RS04140	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DWV08_RS04145	COG2226	methyltransferase
DWV08_RS04170	COG0647	UMP catabolic process
DWV08_RS04180	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DWV08_RS04185	COG0497	DNA recombination
DWV08_RS04215	COG0504	CTP synthase activity
DWV08_RS04225	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DWV08_RS04235	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DWV08_RS04240	COG0596	Alpha beta hydrolase
DWV08_RS04295	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DWV08_RS04310	COG2197	response regulator
DWV08_RS04375	COG3119	arylsulfatase activity
DWV08_RS04385	COG0628	permease
DWV08_RS04415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DWV08_RS04440	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DWV08_RS04455	COG0217	transcriptional regulatory protein
DWV08_RS04460	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DWV08_RS04465	COG0632	four-way junction helicase activity
DWV08_RS04470	COG2255	four-way junction helicase activity
DWV08_RS04480	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DWV08_RS04485	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DWV08_RS04490	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DWV08_RS04495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DWV08_RS04505	COG1196	nuclear chromosome segregation
DWV08_RS04510	COG0124	histidyl-tRNA synthetase
DWV08_RS04515	COG3118	belongs to the thioredoxin family
DWV08_RS04525	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DWV08_RS04550	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DWV08_RS04555	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DWV08_RS04570	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DWV08_RS04575	COG0723	plastoquinol--plastocyanin reductase activity
DWV08_RS04580	COG2010	Cytochrome c
DWV08_RS04585	COG1845	cytochrome c oxidase, subunit III
DWV08_RS04590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DWV08_RS04605	COG1022	Amp-dependent synthetase and ligase
DWV08_RS04610	COG1940	carbohydrate kinase activity
DWV08_RS04630	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DWV08_RS04635	COG2815	serine threonine protein kinase
DWV08_RS04635	COG0515	serine threonine protein kinase
DWV08_RS04645	COG0142	geranyltranstransferase activity
DWV08_RS04655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DWV08_RS04665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DWV08_RS04670	COG0456	acetyltransferase
DWV08_RS04680	COG0187	DNA topoisomerase II activity
DWV08_RS04685	COG0107	imidazoleglycerol-phosphate synthase activity
DWV08_RS04690	COG0676	glucose-6-phosphate 1-epimerase activity
DWV08_RS04700	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DWV08_RS04735	COG0756	dUTP diphosphatase activity
DWV08_RS04750	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DWV08_RS04755	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DWV08_RS04765	COG0024	Methionine aminopeptidase
DWV08_RS04770	COG1612	heme a metabolic process
DWV08_RS04785	COG0435	Glutathione S-transferase
DWV08_RS04810	COG0396	ATPase activity
DWV08_RS04825	COG0488	(ABC) transporter
DWV08_RS04835	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DWV08_RS04840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DWV08_RS04845	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DWV08_RS04850	COG0540	Belongs to the ATCase OTCase family
DWV08_RS04855	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DWV08_RS04865	COG0505	Belongs to the CarA family
DWV08_RS04870	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DWV08_RS04875	COG0284	orotidine-5'-phosphate decarboxylase activity
DWV08_RS04885	COG0194	GDP metabolic process
DWV08_RS04890	COG1758	RNA polymerase activity
DWV08_RS04900	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DWV08_RS04905	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DWV08_RS04930	COG0134	indole-3-glycerol-phosphate synthase activity
DWV08_RS04935	COG0133	tryptophan synthase activity
DWV08_RS04940	COG0159	tryptophan synthase activity
DWV08_RS04950	COG0067	glutamate synthase
DWV08_RS04950	COG0069	glutamate synthase activity
DWV08_RS04950	COG0070	glutamate synthase
DWV08_RS04990	COG0539	negative regulation of cytoplasmic translation
DWV08_RS05000	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DWV08_RS05005	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DWV08_RS05010	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DWV08_RS05020	COG2860	membrane
DWV08_RS05025	COG0237	dephospho-CoA kinase activity
DWV08_RS05030	COG0556	nucleotide-excision repair
DWV08_RS05065	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DWV08_RS05065	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DWV08_RS05080	COG0322	excinuclease ABC activity
DWV08_RS05085	COG1660	Displays ATPase and GTPase activities
DWV08_RS05090	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DWV08_RS05095	COG1481	regulation of sporulation
DWV08_RS05100	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DWV08_RS05105	COG0126	phosphoglycerate kinase activity
DWV08_RS05110	COG0149	triose-phosphate isomerase activity
DWV08_RS05115	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DWV08_RS05120	COG0363	glucosamine-6-phosphate deaminase activity
DWV08_RS05130	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DWV08_RS05140	COG0109	protoheme IX farnesyltransferase activity
DWV08_RS05165	COG1160	GTP binding
DWV08_RS05190	COG1175	transmembrane transport
DWV08_RS05205	COG2409	Drug exporters of the RND superfamily
DWV08_RS05215	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DWV08_RS05220	COG0006	proline dipeptidase activity
DWV08_RS05225	COG1012	belongs to the aldehyde dehydrogenase family
DWV08_RS05250	COG1716	ATPase activity
DWV08_RS05265	COG1192	Involved in chromosome partitioning
DWV08_RS05315	COG0583	DNA-binding transcription factor activity
DWV08_RS05320	COG4638	Rieske (2fe-2S)
DWV08_RS05340	COG2814	Major facilitator Superfamily
DWV08_RS05360	COG2409	Drug exporters of the RND superfamily
DWV08_RS05370	COG0587	DNA-directed DNA polymerase activity
DWV08_RS05395	COG1063	alcohol dehydrogenase
DWV08_RS05400	COG1028	Short-chain dehydrogenase reductase Sdr
DWV08_RS05410	COG1119	ATPase activity
DWV08_RS05425	COG0297	glycogen (starch) synthase activity
DWV08_RS05435	COG0560	Phosphoserine phosphatase
DWV08_RS05435	COG3830	Belongs to the UPF0237 family
DWV08_RS05465	COG0584	glycerophosphoryl diester phosphodiesterase
DWV08_RS05480	COG1216	Glycosyl transferase, family 2
DWV08_RS05485	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DWV08_RS05505	COG0805	protein transport
DWV08_RS05510	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DWV08_RS05530	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DWV08_RS05535	COG0140	phosphoribosyl-ATP diphosphatase activity
DWV08_RS05545	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DWV08_RS05555	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DWV08_RS05560	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DWV08_RS05575	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DWV08_RS05590	COG1222	aaa ATPase
DWV08_RS05610	COG0215	cysteine-tRNA ligase activity
DWV08_RS05615	COG1968	undecaprenyl-diphosphatase activity
DWV08_RS05640	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DWV08_RS05655	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DWV08_RS05660	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DWV08_RS05665	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DWV08_RS05670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DWV08_RS05675	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DWV08_RS05685	COG0167	dihydroorotate dehydrogenase activity
DWV08_RS05700	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DWV08_RS05705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DWV08_RS05710	COG0508	dehydrogenase complex catalyzes the overall conversion of
DWV08_RS05720	COG0321	lipoyl(octanoyl) transferase activity
DWV08_RS05725	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DWV08_RS05740	COG0174	glutamine synthetase
DWV08_RS05755	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DWV08_RS05760	COG0174	glutamine synthetase
DWV08_RS05795	COG3022	response to hydroperoxide
DWV08_RS05800	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DWV08_RS05805	COG0822	iron-sulfur transferase activity
DWV08_RS05830	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DWV08_RS05840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DWV08_RS05845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DWV08_RS05885	COG0358	DNA primase activity
DWV08_RS05890	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DWV08_RS05905	COG1396	sequence-specific DNA binding
DWV08_RS05910	COG0740	serine-type endopeptidase activity
DWV08_RS05915	COG0740	serine-type endopeptidase activity
DWV08_RS05925	COG0423	glycine-tRNA ligase activity
DWV08_RS05935	COG1121	(ABC) transporter
DWV08_RS05940	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DWV08_RS05955	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DWV08_RS05960	COG1381	Involved in DNA repair and RecF pathway recombination
DWV08_RS05980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DWV08_RS05985	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DWV08_RS05995	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DWV08_RS06005	COG0537	adenosine 5'-monophosphoramidase activity
DWV08_RS06020	COG0484	heat shock protein binding
DWV08_RS06025	COG1420	regulation of RNA biosynthetic process
DWV08_RS06050	COG0481	GTPase activity
DWV08_RS06060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DWV08_RS06065	COG0583	DNA-binding transcription factor activity
DWV08_RS06070	COG2186	Transcriptional regulator
DWV08_RS06095	COG0268	Binds directly to 16S ribosomal RNA
DWV08_RS06110	COG1555	photosystem II stabilization
DWV08_RS06120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DWV08_RS06125	COG0318	PFAM AMP-dependent synthetase and ligase
DWV08_RS06130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DWV08_RS06135	COG1082	Xylose isomerase domain protein TIM barrel
DWV08_RS06140	COG1435	thymidine kinase activity
DWV08_RS06150	COG1012	belongs to the aldehyde dehydrogenase family
DWV08_RS06165	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DWV08_RS06175	COG0477	Major facilitator Superfamily
DWV08_RS06180	COG3958	Transketolase
DWV08_RS06190	COG0492	ferredoxin-NADP+ reductase activity
DWV08_RS06195	COG2873	o-acetylhomoserine
DWV08_RS06200	COG2818	Glycosylase
DWV08_RS06215	COG3104	oligopeptide transport
DWV08_RS06230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DWV08_RS06240	COG4608	Belongs to the ABC transporter superfamily
DWV08_RS06255	COG0601	transmembrane transport
DWV08_RS06260	COG4166	transmembrane transport
DWV08_RS06270	COG1120	ATPase activity
DWV08_RS06275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWV08_RS06310	COG4868	Belongs to the UPF0371 family
DWV08_RS06320	COG0673	inositol 2-dehydrogenase activity
DWV08_RS06335	COG1621	beta-fructofuranosidase activity
DWV08_RS06340	COG0514	ATP-dependent DNA helicase (RecQ)
DWV08_RS06355	COG4172	Belongs to the ABC transporter superfamily
DWV08_RS06360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWV08_RS06365	COG0601	transmembrane transport
DWV08_RS06400	COG2855	membrane
DWV08_RS06435	COG0596	Alpha beta hydrolase
DWV08_RS06450	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DWV08_RS06460	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DWV08_RS06470	COG3593	DNA synthesis involved in DNA repair
DWV08_RS06475	COG0542	response to heat
DWV08_RS06525	COG0799	negative regulation of ribosome biogenesis
DWV08_RS06535	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DWV08_RS06545	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DWV08_RS06550	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DWV08_RS06555	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DWV08_RS06560	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DWV08_RS06565	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DWV08_RS06570	COG1530	ribonuclease E activity
DWV08_RS06575	COG1271	oxidase subunit
DWV08_RS06580	COG1294	oxidase, subunit
DWV08_RS06585	COG4988	ABC transporter
DWV08_RS06590	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DWV08_RS06595	COG4585	Histidine kinase
DWV08_RS06605	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DWV08_RS06610	COG0571	ribonuclease III activity
DWV08_RS06615	COG1399	metal-binding, possibly nucleic acid-binding protein
DWV08_RS06620	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DWV08_RS06640	COG0742	ribosomal rna small subunit methyltransferase
DWV08_RS06650	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DWV08_RS06670	COG1181	Belongs to the D-alanine--D-alanine ligase family
DWV08_RS06690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DWV08_RS06695	COG0066	3-isopropylmalate dehydratase activity
DWV08_RS06700	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DWV08_RS06705	COG1414	Transcriptional regulator
DWV08_RS06730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DWV08_RS06780	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DWV08_RS06785	COG1140	nitrate reductase beta subunit
DWV08_RS06805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DWV08_RS06810	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DWV08_RS06815	COG0473	3-isopropylmalate dehydrogenase activity
DWV08_RS06825	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DWV08_RS06830	COG0440	acetolactate synthase activity
DWV08_RS06840	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DWV08_RS06845	COG2146	nitrite reductase [NAD(P)H] activity
DWV08_RS06845	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DWV08_RS06850	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DWV08_RS06850	COG1648	precorrin-2 dehydrogenase activity
DWV08_RS06855	COG0129	dihydroxy-acid dehydratase activity
DWV08_RS06860	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DWV08_RS06865	COG0154	amidase activity
DWV08_RS06870	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DWV08_RS06895	COG0514	ATP-dependent DNA helicase (RecQ)
DWV08_RS06900	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DWV08_RS06910	COG0482	sulfurtransferase activity
DWV08_RS06945	COG0714	Associated with various cellular activities
DWV08_RS06955	COG0366	Alpha amylase catalytic
DWV08_RS06960	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DWV08_RS06980	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
DWV08_RS06985	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DWV08_RS07000	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DWV08_RS07005	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DWV08_RS07010	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DWV08_RS07015	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DWV08_RS07020	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DWV08_RS07025	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DWV08_RS07030	COG0356	it plays a direct role in the translocation of protons across the membrane
DWV08_RS07040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DWV08_RS07055	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DWV08_RS07060	COG0254	rRNA binding
DWV08_RS07080	COG0083	homoserine kinase activity
DWV08_RS07085	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DWV08_RS07090	COG0460	homoserine dehydrogenase
DWV08_RS07130	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DWV08_RS07135	COG0739	heme binding
DWV08_RS07135	COG0741	lytic transglycosylase activity
DWV08_RS07135	COG1196	nuclear chromosome segregation
DWV08_RS07140	COG0745	RESPONSE REGULATOR receiver
DWV08_RS07145	COG2205	protein histidine kinase activity
DWV08_RS07150	COG0567	Dehydrogenase, E1 component
DWV08_RS07150	COG0508	dehydrogenase complex catalyzes the overall conversion of
DWV08_RS07165	COG1595	DNA-templated transcription, initiation
DWV08_RS07175	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DWV08_RS07180	COG1162	GTPase activity
DWV08_RS07185	COG0483	inositol monophosphate 1-phosphatase activity
DWV08_RS07210	COG1615	UPF0182 protein
DWV08_RS07220	COG0629	single-stranded DNA binding
DWV08_RS07230	COG1201	RNA secondary structure unwinding
DWV08_RS07235	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DWV08_RS07250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DWV08_RS07255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWV08_RS07260	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWV08_RS07265	COG1120	ATPase activity
DWV08_RS07310	COG0110	maltose O-acetyltransferase activity
DWV08_RS07320	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DWV08_RS07330	COG2357	RelA SpoT domain protein
DWV08_RS07335	COG1902	pentaerythritol trinitrate reductase activity
DWV08_RS07345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DWV08_RS07365	COG2608	mercury ion transmembrane transporter activity
DWV08_RS07375	COG1937	Protein conserved in bacteria
DWV08_RS07380	COG1309	transcriptional regulator
DWV08_RS07385	COG1028	Short-chain dehydrogenase reductase Sdr
DWV08_RS07390	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DWV08_RS07420	COG0456	acetyltransferase
DWV08_RS07420	COG0454	-acetyltransferase
DWV08_RS07425	COG3012	SEC-C Motif Domain Protein
DWV08_RS07435	COG1028	Short-chain dehydrogenase reductase Sdr
DWV08_RS07445	COG0406	alpha-ribazole phosphatase activity
DWV08_RS07455	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DWV08_RS07460	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DWV08_RS07465	COG1234	tRNA 3'-trailer cleavage
DWV08_RS07470	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DWV08_RS07480	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DWV08_RS07525	COG1643	Atp-dependent helicase
DWV08_RS07550	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DWV08_RS07555	COG0739	heme binding
DWV08_RS07560	COG2177	Part of the ABC transporter FtsEX involved in
DWV08_RS07565	COG2884	Cell division ATP-binding protein ftsE
DWV08_RS07570	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DWV08_RS07575	COG1929	Belongs to the glycerate kinase type-1 family
DWV08_RS07655	COG2135	peptidase activity
DWV08_RS07660	COG4585	Histidine kinase
DWV08_RS07665	COG2197	response regulator
DWV08_RS07670	COG1136	(ABC) transporter
DWV08_RS07670	COG0577	efflux transmembrane transporter activity
DWV08_RS07675	COG4591	ABC-type transport system involved in lipoprotein release permease component
DWV08_RS07735	COG0653	protein targeting
DWV08_RS07745	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DWV08_RS07755	COG5401	PFAM Sporulation and spore germination
DWV08_RS07760	COG5000	phosphorelay sensor kinase activity
DWV08_RS07760	COG5002	protein histidine kinase activity
DWV08_RS07765	COG0745	RESPONSE REGULATOR receiver
DWV08_RS07790	COG0714	Associated with various cellular activities
DWV08_RS07835	COG4981	capsule polysaccharide biosynthetic process
DWV08_RS07845	COG0778	Nitroreductase
DWV08_RS07845	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
DWV08_RS07865	COG1216	Glycosyl transferase, family 2
DWV08_RS07885	COG1316	TRANSCRIPTIONal
DWV08_RS07925	COG0438	transferase activity, transferring glycosyl groups
DWV08_RS07940	COG1132	(ABC) transporter
DWV08_RS07955	COG0673	inositol 2-dehydrogenase activity
DWV08_RS07960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DWV08_RS07965	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DWV08_RS07985	COG2205	protein histidine kinase activity
DWV08_RS07990	COG0745	RESPONSE REGULATOR receiver
DWV08_RS08005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DWV08_RS08020	COG0424	maF-like protein
DWV08_RS08025	COG4770	biotin carboxylase activity
DWV08_RS08040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DWV08_RS08045	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DWV08_RS08065	COG1079	Belongs to the binding-protein-dependent transport system permease family
DWV08_RS08070	COG4603	Belongs to the binding-protein-dependent transport system permease family
DWV08_RS08075	COG3845	ABC transporter
DWV08_RS08080	COG1744	ABC transporter substrate-binding protein PnrA-like
DWV08_RS08085	COG1473	amidohydrolase
DWV08_RS08085	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DWV08_RS08095	COG2009	succinate dehydrogenase
DWV08_RS08105	COG1053	succinate dehydrogenase
DWV08_RS08110	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DWV08_RS08125	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DWV08_RS08130	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DWV08_RS08135	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DWV08_RS08145	COG2030	dehydratase
DWV08_RS08150	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DWV08_RS08170	COG1666	GTP binding
DWV08_RS08195	COG1674	ftsk spoiiie
DWV08_RS08205	COG0515	serine threonine protein kinase
DWV08_RS08205	COG2815	serine threonine protein kinase
DWV08_RS08215	COG0631	protein serine/threonine phosphatase activity
DWV08_RS08235	COG0714	Associated with various cellular activities
DWV08_RS08240	COG0142	geranyltranstransferase activity
DWV08_RS08260	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DWV08_RS08265	COG0165	Argininosuccinate lyase
DWV08_RS08270	COG0137	argininosuccinate synthase activity
DWV08_RS08275	COG1438	arginine binding
DWV08_RS08280	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DWV08_RS08285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DWV08_RS08290	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DWV08_RS08295	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DWV08_RS08300	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DWV08_RS08310	COG0072	phenylalanine-tRNA ligase activity
DWV08_RS08310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DWV08_RS08315	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DWV08_RS08335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DWV08_RS08340	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DWV08_RS08345	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DWV08_RS08350	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DWV08_RS08370	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DWV08_RS08380	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DWV08_RS08390	COG0131	Imidazoleglycerol-phosphate dehydratase
DWV08_RS08395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DWV08_RS08415	COG0395	ABC-type sugar transport system, permease component
DWV08_RS08430	COG1609	Transcriptional regulator
DWV08_RS08435	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DWV08_RS08440	COG0428	transporter
DWV08_RS08450	COG2838	Isocitrate dehydrogenase
DWV08_RS08465	COG3189	MarR family transcriptional regulator
DWV08_RS08475	COG2326	polyphosphate kinase activity
DWV08_RS08485	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
DWV08_RS08490	COG1254	Belongs to the acylphosphatase family
DWV08_RS08500	COG2354	Protein conserved in bacteria
DWV08_RS08525	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
DWV08_RS08525	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DWV08_RS08525	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DWV08_RS08530	COG5522	Integral membrane protein (intg_mem_TP0381)
DWV08_RS08545	COG1435	thymidine kinase activity
DWV08_RS08555	COG2855	membrane
DWV08_RS08570	COG3173	Aminoglycoside phosphotransferase
DWV08_RS08580	COG2211	Major facilitator Superfamily
DWV08_RS08670	COG2814	Major facilitator Superfamily
DWV08_RS08685	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DWV08_RS08715	COG2358	TRAP transporter, solute receptor (TAXI family
DWV08_RS08720	COG2154	pterin-4-alpha-carbinolamine dehydratase
DWV08_RS08750	COG1309	transcriptional regulator
DWV08_RS08760	COG3559	Exporter of polyketide antibiotics
DWV08_RS08765	COG1131	(ABC) transporter
DWV08_RS08785	COG0656	L-ascorbic acid biosynthetic process
DWV08_RS08875	COG1028	Short-chain dehydrogenase reductase Sdr
DWV08_RS08880	COG2207	Transcriptional regulator
DWV08_RS08880	COG3708	Transcriptional regulator
DWV08_RS08885	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DWV08_RS08920	COG0012	GTP binding
DWV08_RS08940	COG2910	NAD(P)H-binding
DWV08_RS08945	COG1733	regulation of RNA biosynthetic process
DWV08_RS08970	COG1722	exodeoxyribonuclease VII activity
DWV08_RS08985	COG0114	fumarate hydratase activity
DWV08_RS09000	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DWV08_RS09005	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DWV08_RS09020	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DWV08_RS09030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DWV08_RS09055	COG0673	inositol 2-dehydrogenase activity
DWV08_RS09070	COG0456	acetyltransferase
DWV08_RS09070	COG1214	PFAM Peptidase M22, glycoprotease
DWV08_RS09075	COG0802	atpase or kinase
DWV08_RS09080	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DWV08_RS09085	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DWV08_RS09090	COG0736	holo-[acyl-carrier-protein] synthase activity
DWV08_RS09095	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DWV08_RS09100	COG1072	(Pantothenic acid kinase))
DWV08_RS09105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DWV08_RS09110	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DWV08_RS09115	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DWV08_RS09120	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DWV08_RS09125	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DWV08_RS09130	COG0101	tRNA pseudouridine synthase activity
DWV08_RS09135	COG0151	Belongs to the GarS family
DWV08_RS09140	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DWV08_RS09145	COG3845	ABC transporter
DWV08_RS09160	COG1234	tRNA 3'-trailer cleavage
DWV08_RS09165	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DWV08_RS09170	COG0047	phosphoribosylformylglycinamidine synthase activity
DWV08_RS09175	COG2813	Specifically methylates the guanine in position
DWV08_RS09180	COG1741	Belongs to the pirin family
DWV08_RS09200	COG0789	Transcriptional regulator
DWV08_RS09225	COG0183	Belongs to the thiolase family
DWV08_RS09240	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DWV08_RS09250	COG0203	ribosomal protein L17
DWV08_RS09255	COG0202	RNA polymerase activity
DWV08_RS09260	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DWV08_RS09265	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DWV08_RS09270	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DWV08_RS09275	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DWV08_RS09285	COG0563	adenylate kinase activity
DWV08_RS09290	COG0201	protein transport
DWV08_RS09295	COG0200	Binds to the 23S rRNA
DWV08_RS09300	COG1841	ribosomal large subunit assembly
DWV08_RS09305	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DWV08_RS09310	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DWV08_RS09315	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DWV08_RS09320	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DWV08_RS09325	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DWV08_RS09330	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DWV08_RS09335	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DWV08_RS09340	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DWV08_RS09350	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DWV08_RS09355	COG0255	Belongs to the universal ribosomal protein uL29 family
DWV08_RS09360	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DWV08_RS09365	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DWV08_RS09370	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DWV08_RS09375	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DWV08_RS09380	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DWV08_RS09385	COG0089	rRNA binding
DWV08_RS09390	COG0088	Forms part of the polypeptide exit tunnel
DWV08_RS09395	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DWV08_RS09400	COG0051	transcription antitermination factor activity, RNA binding
DWV08_RS09405	COG0395	ABC-type sugar transport system, permease component
DWV08_RS09410	COG1175	transmembrane transport
DWV08_RS09415	COG1653	transport
DWV08_RS09425	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DWV08_RS09430	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DWV08_RS09435	COG0049	tRNA binding
DWV08_RS09440	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DWV08_RS09445	COG3583	domain protein
DWV08_RS09450	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DWV08_RS09455	COG0085	RNA polymerase activity
DWV08_RS09460	COG0222	ribosome binding
DWV08_RS09465	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DWV08_RS09475	COG0081	regulation of translation
DWV08_RS09480	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DWV08_RS09500	COG0436	Aminotransferase
DWV08_RS09505	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DWV08_RS09510	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DWV08_RS09530	COG1027	Aspartate ammonia-lyase
DWV08_RS09535	COG2326	polyphosphate kinase activity
DWV08_RS09540	COG0138	bifunctional purine biosynthesis protein purh
DWV08_RS09560	COG1169	isochorismate synthase
DWV08_RS09565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DWV08_RS09570	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DWV08_RS09575	COG4948	Mandelate Racemase Muconate Lactonizing
DWV08_RS09580	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DWV08_RS09605	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DWV08_RS09625	COG0406	alpha-ribazole phosphatase activity
DWV08_RS09650	COG1160	GTP binding
DWV08_RS09660	COG0123	including yeast histone deacetylase and acetoin utilization protein
DWV08_RS09665	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DWV08_RS09670	COG0569	domain protein
DWV08_RS09675	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DWV08_RS09700	COG2372	response to copper ion
DWV08_RS09740	COG2188	Transcriptional regulator
DWV08_RS09745	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DWV08_RS09780	COG3321	synthase
DWV08_RS09780	COG1028	Short-chain dehydrogenase reductase Sdr
DWV08_RS09780	COG0604	alcohol dehydrogenase
DWV08_RS09785	COG1506	peptidase
DWV08_RS09785	COG0823	Involved in the tonB-independent uptake of proteins
DWV08_RS09800	COG0387	Pfam Sodium calcium exchanger
DWV08_RS09815	COG4176	ABC-type proline glycine betaine transport system permease component
DWV08_RS09825	COG0673	inositol 2-dehydrogenase activity
DWV08_RS09830	COG1940	carbohydrate kinase activity
DWV08_RS09830	COG1846	Transcriptional regulator
DWV08_RS09840	COG1175	transmembrane transport
DWV08_RS09845	COG0395	ABC-type sugar transport system, permease component
DWV08_RS09855	COG0366	Alpha amylase catalytic
DWV08_RS09880	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DWV08_RS09885	COG3639	organic phosphonate transmembrane transporter activity
DWV08_RS09890	COG3639	organic phosphonate transmembrane transporter activity
DWV08_RS09905	COG0477	Major facilitator Superfamily
DWV08_RS09925	COG1115	amino acid carrier protein
DWV08_RS09930	COG0456	acetyltransferase
DWV08_RS09940	COG1917	Cupin 2, conserved barrel domain protein
DWV08_RS09950	COG1739	Uncharacterized protein family UPF0029
DWV08_RS09980	COG1028	Short-chain dehydrogenase reductase Sdr
DWV08_RS09985	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DWV08_RS10020	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DWV08_RS10025	COG1780	Probably involved in ribonucleotide reductase function
DWV08_RS10030	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DWV08_RS10090	COG4585	Histidine kinase
DWV08_RS10095	COG2197	response regulator
DWV08_RS10120	COG2130	NADP-dependent
DWV08_RS10250	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DWV08_RS10270	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DWV08_RS10310	COG1396	sequence-specific DNA binding
DWV08_RS10350	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DWV08_RS10360	COG1283	sodium-dependent phosphate transmembrane transporter activity
DWV08_RS10365	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DWV08_RS10385	COG0651	ATP synthesis coupled electron transport
DWV08_RS10390	COG1006	Multisubunit Na H antiporter MnhC subunit
DWV08_RS10395	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DWV08_RS10395	COG2111	Na H antiporter
DWV08_RS10410	COG0717	Belongs to the dCTP deaminase family
DWV08_RS10435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DWV08_RS10440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DWV08_RS10450	COG0488	(ABC) transporter
DWV08_RS10455	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DWV08_RS10465	COG2072	flavoprotein involved in K transport
DWV08_RS10480	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DWV08_RS10485	COG0508	dehydrogenase complex catalyzes the overall conversion of
DWV08_RS10490	COG0022	dehydrogenase e1 component
DWV08_RS10500	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DWV08_RS10510	COG0395	ABC-type sugar transport system, permease component
DWV08_RS10515	COG1175	transmembrane transport
DWV08_RS10540	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DWV08_RS10545	COG1950	PFAM Membrane protein of
DWV08_RS10550	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DWV08_RS10555	COG0300	oxidoreductase activity
DWV08_RS10575	COG1136	(ABC) transporter
DWV08_RS10580	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DWV08_RS10610	COG0456	acetyltransferase
DWV08_RS10630	COG0354	folic acid binding
DWV08_RS10660	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DWV08_RS10665	COG0300	oxidoreductase activity
DWV08_RS10670	COG0708	Exodeoxyribonuclease III
DWV08_RS10710	COG1205	dead DEAH box helicase
DWV08_RS10710	COG1111	helicase
DWV08_RS10725	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DWV08_RS10725	COG1754	DNA topoisomerase type I activity
DWV08_RS10730	COG1653	transport
DWV08_RS10735	COG1175	transmembrane transport
DWV08_RS10740	COG0395	ABC-type sugar transport system, permease component
DWV08_RS10750	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DWV08_RS10755	COG0470	DNA polymerase III
DWV08_RS10765	COG1278	Cold shock
DWV08_RS10810	COG4592	Periplasmic binding protein
DWV08_RS10815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWV08_RS10820	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWV08_RS10825	COG1120	ATPase activity
DWV08_RS10830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWV08_RS10840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DWV08_RS10845	COG1408	metallophosphoesterase
DWV08_RS10860	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DWV08_RS10875	COG3281	Trehalose synthase
DWV08_RS10890	COG1120	ATPase activity
DWV08_RS10895	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWV08_RS10900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWV08_RS10935	COG1175	transmembrane transport
DWV08_RS10940	COG0395	ABC-type sugar transport system, permease component
DWV08_RS10955	COG0343	queuine tRNA-ribosyltransferase activity
DWV08_RS10965	COG1215	transferase activity, transferring glycosyl groups
DWV08_RS11000	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DWV08_RS11005	COG2755	lipolytic protein G-D-S-L family
DWV08_RS11005	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DWV08_RS11010	COG1362	aminopeptidase activity
DWV08_RS11025	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DWV08_RS11030	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DWV08_RS11040	COG3253	May function as heme-dependent peroxidase
DWV08_RS11045	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DWV08_RS11050	COG0181	hydroxymethylbilane synthase activity
DWV08_RS11060	COG0113	porphobilinogen synthase activity
DWV08_RS11065	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DWV08_RS11085	COG1832	CoA-binding protein
DWV08_RS11100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DWV08_RS11105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DWV08_RS11150	COG0438	transferase activity, transferring glycosyl groups
DWV08_RS11170	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DWV08_RS11180	COG1716	ATPase activity
DWV08_RS11195	COG0768	penicillin binding
DWV08_RS11205	COG0515	serine threonine protein kinase
DWV08_RS11220	COG3764	Sortase (surface protein transpeptidase)
DWV08_RS11245	COG0640	Transcriptional regulator
DWV08_RS11255	COG0673	inositol 2-dehydrogenase activity
DWV08_RS11295	COG1132	(ABC) transporter
DWV08_RS11300	COG1132	(ABC) transporter
DWV08_RS11310	COG1120	ATPase activity
DWV08_RS11325	COG1126	abc transporter atp-binding protein
DWV08_RS11330	COG0765	amino acid transport
DWV08_RS11375	COG1132	(ABC) transporter
DWV08_RS11380	COG1132	(ABC) transporter
DWV08_RS11390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DWV08_RS11400	COG1028	Short-chain dehydrogenase reductase Sdr
DWV08_RS11410	COG0419	ATPase involved in DNA repair
DWV08_RS11415	COG0420	3'-5' exonuclease activity
DWV08_RS11425	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DWV08_RS11425	COG0352	thiamine-phosphate diphosphorylase activity
DWV08_RS11425	COG0351	phosphomethylpyrimidine kinase
DWV08_RS11435	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DWV08_RS11440	COG0352	thiamine-phosphate diphosphorylase activity
DWV08_RS11455	COG3971	2-oxopent-4-enoate hydratase activity
DWV08_RS11475	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DWV08_RS11500	COG2226	methyltransferase
DWV08_RS11525	COG4085	toxin activity
DWV08_RS11525	COG1525	nuclease
DWV08_RS11525	COG0737	Belongs to the 5'-nucleotidase family
DWV08_RS11530	COG1252	NADH dehydrogenase
DWV08_RS11545	COG0714	Associated with various cellular activities
DWV08_RS11560	COG0039	L-malate dehydrogenase activity
DWV08_RS11565	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DWV08_RS11600	COG1752	Esterase of the alpha-beta hydrolase superfamily
DWV08_RS11605	COG2205	protein histidine kinase activity
DWV08_RS11605	COG2202	Pas domain
DWV08_RS11615	COG0745	RESPONSE REGULATOR receiver
DWV08_RS11640	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DWV08_RS11655	COG0463	Glycosyl transferase, family 2
DWV08_RS11665	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DWV08_RS11670	COG1134	teichoic acid transport
DWV08_RS11680	COG0438	transferase activity, transferring glycosyl groups
DWV08_RS11685	COG1116	anion transmembrane transporter activity
DWV08_RS11690	COG4521	taurine ABC transporter
DWV08_RS11695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DWV08_RS11715	COG3540	Alkaline phosphatase
DWV08_RS11725	COG1937	Protein conserved in bacteria
DWV08_RS11730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DWV08_RS11760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DWV08_RS11765	COG1940	carbohydrate kinase activity
DWV08_RS11815	COG1309	transcriptional regulator
DWV08_RS11850	COG1175	transmembrane transport
DWV08_RS11855	COG0395	ABC-type sugar transport system, permease component
DWV08_RS11860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DWV08_RS11860	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DWV08_RS11865	COG1175	transmembrane transport
DWV08_RS11875	COG1653	transport
DWV08_RS11880	COG1131	(ABC) transporter
DWV08_RS11895	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DWV08_RS11935	COG1823	symporter activity
DWV08_RS11945	COG1090	epimerase
DWV08_RS11955	COG1115	amino acid carrier protein
DWV08_RS11960	COG0667	Aldo Keto reductase
DWV08_RS12000	COG0569	domain protein
DWV08_RS12005	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DWV08_RS12025	COG0519	Catalyzes the synthesis of GMP from XMP
DWV08_RS12030	COG0259	pyridoxamine-phosphate oxidase activity
DWV08_RS12035	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DWV08_RS12045	COG0733	neurotransmitter:sodium symporter activity
DWV08_RS12060	COG0798	PFAM Bile acid sodium symporter
DWV08_RS12070	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DWV08_RS12080	COG1122	ATPase activity
DWV08_RS12095	COG1609	Transcriptional regulator
DWV08_RS12115	COG0823	Involved in the tonB-independent uptake of proteins
DWV08_RS12115	COG1506	peptidase
DWV08_RS12120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWV08_RS12135	COG3119	arylsulfatase activity
DWV08_RS12145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DWV08_RS12150	COG1609	Transcriptional regulator
DWV08_RS12165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWV08_RS12175	COG0747	negative chemotaxis
DWV08_RS12180	COG1609	Transcriptional regulator
DWV08_RS12200	COG0673	inositol 2-dehydrogenase activity
DWV08_RS12230	COG0563	adenylate kinase activity
DWV08_RS12240	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DWV08_RS12250	COG0640	Transcriptional regulator
DWV08_RS12265	COG3534	alpha-L-arabinofuranosidase
DWV08_RS12280	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DWV08_RS12300	COG0395	ABC-type sugar transport system, permease component
DWV08_RS12305	COG1175	transmembrane transport
DWV08_RS12315	COG1609	Transcriptional regulator
DWV08_RS12320	COG1069	ribulokinase activity
DWV08_RS12330	COG2160	L-arabinose isomerase activity
DWV08_RS12335	COG0277	FAD linked oxidase domain protein
DWV08_RS12360	COG1940	carbohydrate kinase activity
DWV08_RS12370	COG0395	ABC-type sugar transport system, permease component
DWV08_RS12375	COG1175	transmembrane transport
DWV08_RS12390	COG1175	transmembrane transport
DWV08_RS12395	COG0395	ABC-type sugar transport system, permease component
DWV08_RS12415	COG0657	acetylesterase activity
DWV08_RS12425	COG4952	isomerase
DWV08_RS12430	COG1028	Short-chain dehydrogenase reductase Sdr
DWV08_RS12430	COG3347	Dehydrogenase
DWV08_RS12435	COG1070	Carbohydrate kinase
DWV08_RS12450	COG3250	beta-galactosidase activity
DWV08_RS12455	COG1609	Transcriptional regulator
DWV08_RS12460	COG4166	transmembrane transport
DWV08_RS12475	COG0444	Belongs to the ABC transporter superfamily
DWV08_RS12480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWV08_RS12505	COG0673	inositol 2-dehydrogenase activity
DWV08_RS12510	COG0395	ABC-type sugar transport system, permease component
DWV08_RS12515	COG1175	transmembrane transport
DWV08_RS12540	COG0586	Pfam SNARE associated Golgi protein
DWV08_RS12555	COG1960	acyl-CoA dehydrogenase activity
DWV08_RS12565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWV08_RS12570	COG0601	transmembrane transport
DWV08_RS12575	COG0747	negative chemotaxis
DWV08_RS12585	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DWV08_RS12590	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DWV08_RS12600	COG0477	Major facilitator Superfamily
DWV08_RS12605	COG0698	ribose 5-phosphate isomerase
DWV08_RS12610	COG2376	Dihydroxyacetone kinase
DWV08_RS12615	COG2814	Major facilitator Superfamily
DWV08_RS12625	COG1172	Belongs to the binding-protein-dependent transport system permease family
DWV08_RS12630	COG1129	ABC transporter
DWV08_RS12640	COG1063	alcohol dehydrogenase
DWV08_RS12650	COG1070	Carbohydrate kinase
DWV08_RS12660	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DWV08_RS12665	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DWV08_RS12670	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DWV08_RS12675	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DWV08_RS12680	COG2390	Transcriptional regulator
DWV08_RS12690	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DWV08_RS12740	COG0702	epimerase
DWV08_RS12750	COG1174	glycine betaine transport
DWV08_RS12760	COG0517	IMP dehydrogenase activity
DWV08_RS12760	COG1125	glycine betaine transport
DWV08_RS12770	COG0765	amino acid transport
DWV08_RS12775	COG0765	amino acid transport
DWV08_RS12780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DWV08_RS12785	COG1126	abc transporter atp-binding protein
DWV08_RS12790	COG0351	phosphomethylpyrimidine kinase
DWV08_RS12800	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DWV08_RS12815	COG1024	Enoyl-CoA hydratase
DWV08_RS12815	COG1250	3-hydroxyacyl-CoA dehydrogenase
DWV08_RS12840	COG0667	Aldo Keto reductase
DWV08_RS12895	COG0183	Belongs to the thiolase family
DWV08_RS12910	COG1263	PTS System
DWV08_RS12910	COG2190	(PTS) system
DWV08_RS12910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DWV08_RS12925	COG0259	pyridoxamine-phosphate oxidase activity
DWV08_RS12960	COG0386	Belongs to the glutathione peroxidase family
DWV08_RS12965	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DWV08_RS12975	COG0793	Belongs to the peptidase S41A family
DWV08_RS12975	COG4946	Tricorn protease homolog
DWV08_RS13005	COG0651	ATP synthesis coupled electron transport
DWV08_RS13010	COG1006	Multisubunit Na H antiporter MnhC subunit
DWV08_RS13015	COG2111	Na H antiporter
DWV08_RS13015	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DWV08_RS13025	COG0589	response to stress
DWV08_RS13030	COG0531	amino acid
DWV08_RS13070	COG4941	Belongs to the sigma-70 factor family
DWV08_RS13105	COG1028	Short-chain dehydrogenase reductase Sdr
DWV08_RS13120	COG2986	histidine ammonia-lyase
DWV08_RS13125	COG3314	Sporulation integral membrane protein YlbJ
DWV08_RS13130	COG1228	amidohydrolase
DWV08_RS13150	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DWV08_RS13165	COG0010	Belongs to the arginase family
DWV08_RS13175	COG2318	DinB family
DWV08_RS13200	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DWV08_RS13205	COG0584	glycerophosphoryl diester phosphodiesterase
DWV08_RS13220	COG0395	ABC-type sugar transport system, permease component
DWV08_RS13225	COG1175	transmembrane transport
DWV08_RS13230	COG1609	Transcriptional regulator
DWV08_RS13235	COG1528	Iron-storage protein
DWV08_RS13245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWV08_RS13265	COG4946	Tricorn protease homolog
DWV08_RS13265	COG0793	Belongs to the peptidase S41A family
DWV08_RS13275	COG0583	DNA-binding transcription factor activity
DWV08_RS13285	COG0371	Dehydrogenase
DWV08_RS13295	COG0823	Involved in the tonB-independent uptake of proteins
DWV08_RS13305	COG0673	inositol 2-dehydrogenase activity
DWV08_RS13310	COG1609	Transcriptional regulator
DWV08_RS13320	COG2847	Copper chaperone PCu(A)C
DWV08_RS13355	COG1904	glucuronate isomerase
DWV08_RS13360	COG1609	Transcriptional regulator
DWV08_RS13375	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DWV08_RS13375	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DWV08_RS13385	COG2076	Multidrug Resistance protein
DWV08_RS13395	COG1691	(AIR) carboxylase
DWV08_RS13400	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DWV08_RS13435	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DWV08_RS13440	COG1121	(ABC) transporter
DWV08_RS13480	COG1136	(ABC) transporter
DWV08_RS13510	COG0789	Transcriptional regulator
DWV08_RS13515	COG0659	secondary active sulfate transmembrane transporter activity
DWV08_RS13535	COG1302	Protein conserved in bacteria
DWV08_RS13570	COG0183	Belongs to the thiolase family
DWV08_RS13615	COG2223	nitrite transmembrane transporter activity
DWV08_RS13640	COG0667	Aldo Keto reductase
DWV08_RS13665	COG0477	Major facilitator Superfamily
DWV08_RS13685	COG0738	Major facilitator superfamily
DWV08_RS13695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DWV08_RS13720	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DWV08_RS13745	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DWV08_RS13755	COG1253	flavin adenine dinucleotide binding
DWV08_RS13780	COG0693	protein deglycase activity
DWV08_RS13785	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DWV08_RS13790	COG3119	arylsulfatase activity
DWV08_RS13810	COG0673	inositol 2-dehydrogenase activity
DWV08_RS13815	COG1063	alcohol dehydrogenase
DWV08_RS13825	COG1012	belongs to the aldehyde dehydrogenase family
DWV08_RS13845	COG0359	binds to the 23S rRNA
DWV08_RS13850	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DWV08_RS13860	COG0360	Binds together with S18 to 16S ribosomal RNA
DWV08_RS13865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DWV08_RS13870	COG0617	tRNA 3'-terminal CCA addition
DWV08_RS13890	COG0492	ferredoxin-NADP+ reductase activity
DWV08_RS13905	COG1192	Involved in chromosome partitioning
DWV08_RS13910	COG0357	Ribosomal RNA small subunit methyltransferase G
DWV08_RS13920	COG0706	membrane insertase activity
DWV08_RS13925	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DWV08_RS13930	COG0594	ribonuclease P activity
DWV08_RS13935	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DWV08_RS13940	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DWV08_RS13945	COG0592	DNA-directed DNA polymerase activity
DWV08_RS13950	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DWV08_RS13955	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
DWV08_RS13970	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DWV08_RS13970	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DWV08_RS13975	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DWV08_RS13980	COG0187	DNA topoisomerase II activity
DWV08_RS13985	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DWV08_RS13995	COG0442	prolyl-tRNA aminoacylation
DWV08_RS14005	COG0415	Belongs to the DNA photolyase family
DWV08_RS14020	COG1595	DNA-templated transcription, initiation
DWV08_RS14065	COG1309	transcriptional regulator
DWV08_RS14070	COG3321	synthase
DWV08_RS14070	COG0604	alcohol dehydrogenase
DWV08_RS14070	COG1028	Short-chain dehydrogenase reductase Sdr
DWV08_RS14090	COG1737	Transcriptional regulator
DWV08_RS14095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DWV08_RS14095	COG2190	(PTS) system
DWV08_RS14095	COG1263	PTS System
DWV08_RS14130	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DWV08_RS14135	COG0443	Heat shock 70 kDa protein
DWV08_RS14175	COG1136	(ABC) transporter
DWV08_RS14180	COG0577	efflux transmembrane transporter activity
DWV08_RS14190	COG2197	response regulator
DWV08_RS14215	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DWV08_RS14220	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DWV08_RS14230	COG4166	transmembrane transport
DWV08_RS14235	COG0601	transmembrane transport
DWV08_RS14240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWV08_RS14270	COG1609	Transcriptional regulator
DWV08_RS14275	COG3459	Glycosyltransferase 36 associated
DWV08_RS14285	COG0110	maltose O-acetyltransferase activity
DWV08_RS14290	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DWV08_RS14300	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DWV08_RS14310	COG1028	Short-chain dehydrogenase reductase Sdr
DWV08_RS14320	COG3959	Transketolase, thiamine diphosphate binding domain
DWV08_RS14325	COG3958	Transketolase
DWV08_RS14330	COG0673	inositol 2-dehydrogenase activity
DWV08_RS14335	COG0673	inositol 2-dehydrogenase activity
DWV08_RS14340	COG1522	sequence-specific DNA binding
DWV08_RS14350	COG0022	dehydrogenase e1 component
DWV08_RS14355	COG0508	dehydrogenase complex catalyzes the overall conversion of
DWV08_RS14360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DWV08_RS14380	COG1960	acyl-CoA dehydrogenase activity
DWV08_RS14405	COG0149	triose-phosphate isomerase activity
DWV08_RS14410	COG0698	ribose 5-phosphate isomerase
DWV08_RS14415	COG2376	Dihydroxyacetone kinase
DWV08_RS14420	COG2610	gluconate transmembrane transporter activity
DWV08_RS14425	COG2084	Dehydrogenase
DWV08_RS14430	COG1082	Xylose isomerase domain protein TIM barrel
DWV08_RS14450	COG1250	3-hydroxyacyl-CoA dehydrogenase
DWV08_RS14455	COG2610	gluconate transmembrane transporter activity
DWV08_RS14465	COG2084	Dehydrogenase
DWV08_RS14475	COG0179	Fumarylacetoacetate (FAA) hydrolase
DWV08_RS14480	COG4948	Mandelate Racemase Muconate Lactonizing
DWV08_RS14500	COG2186	Transcriptional regulator
DWV08_RS14505	COG1653	transport
DWV08_RS14510	COG1175	transmembrane transport
DWV08_RS14535	COG0673	inositol 2-dehydrogenase activity
DWV08_RS14540	COG1082	Xylose isomerase domain protein TIM barrel
DWV08_RS14545	COG1082	Xylose isomerase domain protein TIM barrel
DWV08_RS14555	COG3962	Belongs to the TPP enzyme family
DWV08_RS14565	COG1082	Xylose isomerase domain protein TIM barrel
DWV08_RS14570	COG1942	4-Oxalocrotonate Tautomerase
DWV08_RS14585	COG3718	enzyme involved in inositol metabolism
DWV08_RS14590	COG0673	inositol 2-dehydrogenase activity
DWV08_RS14595	COG2814	Major facilitator Superfamily
DWV08_RS14600	COG2188	Transcriptional regulator
DWV08_RS14615	COG1028	Short-chain dehydrogenase reductase Sdr
DWV08_RS14640	COG0656	L-ascorbic acid biosynthetic process
DWV08_RS14645	COG1486	melibiose metabolic process
DWV08_RS14650	COG1349	DNA-binding transcription factor activity
DWV08_RS14660	COG1175	transmembrane transport
DWV08_RS14665	COG0395	ABC-type sugar transport system, permease component
DWV08_RS14735	COG0494	nUDIX hydrolase
DWV08_RS14765	COG1609	Transcriptional regulator
DWV08_RS14785	COG0667	Aldo Keto reductase
DWV08_RS14790	COG3119	arylsulfatase activity
DWV08_RS14810	COG2318	DinB family
DWV08_RS14825	COG0569	domain protein
DWV08_RS14825	COG2985	domain, Protein
DWV08_RS14835	COG2814	Major facilitator Superfamily
DWV08_RS14840	COG1846	Transcriptional regulator
DWV08_RS14845	COG1063	alcohol dehydrogenase
DWV08_RS14850	COG0246	Mannitol dehydrogenase
DWV08_RS14895	COG0673	inositol 2-dehydrogenase activity
DWV08_RS14905	COG1175	transmembrane transport
DWV08_RS14920	COG1940	carbohydrate kinase activity
DWV08_RS14930	COG2115	Belongs to the xylose isomerase family
DWV08_RS14935	COG1070	Carbohydrate kinase
DWV08_RS14940	COG2315	Protein conserved in bacteria
DWV08_RS14945	COG3458	cephalosporin-C deacetylase activity
DWV08_RS14955	COG1501	Belongs to the glycosyl hydrolase 31 family
DWV08_RS14960	COG1472	Belongs to the glycosyl hydrolase 3 family
DWV08_RS14970	COG4209	transmembrane transport
DWV08_RS14975	COG0395	ABC-type sugar transport system, permease component
DWV08_RS14985	COG1609	Transcriptional regulator
DWV08_RS15000	COG0395	ABC-type sugar transport system, permease component
DWV08_RS15005	COG1175	transmembrane transport
DWV08_RS15020	COG0673	inositol 2-dehydrogenase activity
DWV08_RS15030	COG4989	oxidoreductase activity
DWV08_RS15035	COG2814	Major facilitator Superfamily
DWV08_RS15050	COG0395	ABC-type sugar transport system, permease component
DWV08_RS15055	COG2182	Extracellular solute-binding protein
DWV08_RS15065	COG0673	inositol 2-dehydrogenase activity
DWV08_RS15080	COG2514	catechol 2,3-dioxygenase activity
DWV08_RS15090	COG1511	domain protein
DWV08_RS15095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DWV08_RS15125	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DWV08_RS15140	COG1132	(ABC) transporter
DWV08_RS15145	COG1132	(ABC) transporter
DWV08_RS15160	COG1461	Dihydroxyacetone kinase
DWV08_RS15165	COG2376	Dihydroxyacetone kinase
DWV08_RS15205	COG0583	DNA-binding transcription factor activity
DWV08_RS15215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWV08_RS15225	COG1126	abc transporter atp-binding protein
DWV08_RS15265	COG1595	DNA-templated transcription, initiation
DWV08_RS15290	COG1136	(ABC) transporter
DWV08_RS15290	COG0577	efflux transmembrane transporter activity
DWV08_RS15305	COG1253	flavin adenine dinucleotide binding
DWV08_RS15315	COG0028	Belongs to the TPP enzyme family
DWV08_RS15320	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DWV08_RS15355	COG1083	cytidylyl-transferase
DWV08_RS15360	COG2089	acid synthase
DWV08_RS15380	COG0438	transferase activity, transferring glycosyl groups
DWV08_RS15430	COG1216	Glycosyl transferase, family 2
DWV08_RS15430	COG0438	transferase activity, transferring glycosyl groups
DWV08_RS15440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DWV08_RS15485	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DWV08_RS15500	COG1012	belongs to the aldehyde dehydrogenase family
DWV08_RS15510	COG0477	Major facilitator Superfamily
DWV08_RS15525	COG1652	LysM domain
DWV08_RS15535	COG0477	Major facilitator Superfamily
DWV08_RS15545	COG1063	alcohol dehydrogenase
DWV08_RS15560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DWV08_RS15565	COG5002	protein histidine kinase activity
DWV08_RS15570	COG0745	RESPONSE REGULATOR receiver
DWV08_RS15605	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DWV08_RS15625	COG0305	Participates in initiation and elongation during chromosome replication
DWV08_RS15630	COG2233	PERMEase
DWV08_RS15640	COG0657	acetylesterase activity
DWV08_RS15675	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DWV08_RS15690	COG0745	RESPONSE REGULATOR receiver
DWV08_RS15695	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DWV08_RS15705	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DWV08_RS15710	COG0590	tRNA wobble adenosine to inosine editing
DWV08_RS15720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DWV08_RS15725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DWV08_RS15730	COG2197	response regulator
DWV08_RS15750	COG1131	(ABC) transporter
DWV08_RS15760	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DWV08_RS15765	COG2011	ABC-type metal ion transport system permease component
DWV08_RS15770	COG1464	Belongs to the NlpA lipoprotein family
DWV08_RS15795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWV08_RS15805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DWV08_RS15810	COG0783	Belongs to the Dps family
DWV08_RS15835	COG0252	asparaginase activity
DWV08_RS15845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DWV08_RS15855	COG1643	Atp-dependent helicase
DWV08_RS15875	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DWV08_RS15880	COG0385	Bile acid
DWV08_RS15895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DWV08_RS15905	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DWV08_RS15910	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DWV08_RS15920	COG1104	cysteine desulfurase activity
DWV08_RS15960	COG0656	L-ascorbic acid biosynthetic process
DWV08_RS15975	COG4948	Mandelate Racemase Muconate Lactonizing
DWV08_RS15990	COG3842	ATPase activity
DWV08_RS15995	COG1653	transport
DWV08_RS16000	COG0395	ABC-type sugar transport system, permease component
DWV08_RS16005	COG1175	transmembrane transport
DWV08_RS16010	COG3387	PFAM Glycoside hydrolase 15-related
DWV08_RS16025	COG1175	transmembrane transport
DWV08_RS16030	COG0395	ABC-type sugar transport system, permease component
DWV08_RS16055	COG0395	ABC-type sugar transport system, permease component
DWV08_RS16060	COG4209	transmembrane transport
DWV08_RS16065	COG0673	inositol 2-dehydrogenase activity
DWV08_RS16075	COG3119	arylsulfatase activity
DWV08_RS16085	COG0254	rRNA binding
DWV08_RS16095	COG0254	rRNA binding
DWV08_RS16100	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DWV08_RS16105	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DWV08_RS16110	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DWV08_RS16150	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DWV08_RS16160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWV08_RS16170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DWV08_RS16205	COG0702	epimerase
DWV08_RS16220	COG2271	Major facilitator Superfamily
DWV08_RS16240	COG1028	Short-chain dehydrogenase reductase Sdr
DWV08_RS16240	COG3321	synthase
DWV08_RS16240	COG0604	alcohol dehydrogenase
DWV08_RS16245	COG3938	Belongs to the proline racemase family
DWV08_RS16250	COG1024	Enoyl-CoA hydratase
DWV08_RS16255	COG1028	Short-chain dehydrogenase reductase Sdr
DWV08_RS16260	COG1960	acyl-CoA dehydrogenase activity
DWV08_RS16270	COG2814	Major facilitator Superfamily
DWV08_RS16280	COG2391	methyltransferase activity
DWV08_RS16285	COG0425	Belongs to the sulfur carrier protein TusA family
DWV08_RS16305	COG0515	serine threonine protein kinase
DWV08_RS16365	COG1716	ATPase activity
DWV08_RS16365	COG1131	(ABC) transporter
DWV08_RS16365	COG0842	Transport permease protein
DWV08_RS16370	COG1716	ATPase activity
DWV08_RS16370	COG1131	(ABC) transporter
DWV08_RS16370	COG0842	Transport permease protein
DWV08_RS16385	COG4221	oxidoreductase activity
DWV08_RS16390	COG1028	Short-chain dehydrogenase reductase Sdr
DWV08_RS16415	COG1621	beta-fructofuranosidase activity
DWV08_RS16420	COG1609	Transcriptional regulator
DWV08_RS16425	COG0395	ABC-type sugar transport system, permease component
DWV08_RS16430	COG1175	transmembrane transport
DWV08_RS16435	COG1653	transport
DWV08_RS16450	COG1609	Transcriptional regulator
DWV08_RS16460	COG1175	transmembrane transport
DWV08_RS16465	COG0395	ABC-type sugar transport system, permease component
DWV08_RS16480	COG1486	melibiose metabolic process
DWV08_RS16510	COG3386	PFAM SMP-30 Gluconolaconase
DWV08_RS16545	COG1063	alcohol dehydrogenase
DWV08_RS16550	COG1309	transcriptional regulator
DWV08_RS16560	COG1609	Transcriptional regulator
DWV08_RS16565	COG3250	beta-galactosidase activity
DWV08_RS16575	COG1028	Short-chain dehydrogenase reductase Sdr
DWV08_RS16580	COG2072	flavoprotein involved in K transport
DWV08_RS16620	COG2963	transposase activity
DWV08_RS16625	COG3421	Type III restriction
DWV08_RS16625	COG3421	Type III restriction
DWV08_RS16630	COG2189	Belongs to the N(4) N(6)-methyltransferase family
DWV08_RS16650	COG1595	DNA-templated transcription, initiation
DWV08_RS16665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released