locus-tag	class	description
B2904_RS00020	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B2904_RS00050	COG1054	Belongs to the UPF0176 family
B2904_RS00075	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B2904_RS00105	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B2904_RS00110	COG1346	cytolysis
B2904_RS00115	COG1380	Effector of murein hydrolase LrgA
B2904_RS00125	COG0742	ribosomal rna small subunit methyltransferase
B2904_RS00150	COG3458	cephalosporin-C deacetylase activity
B2904_RS00165	COG1442	glycosyl transferase family 8
B2904_RS00165	COG1216	Glycosyl transferase, family 2
B2904_RS00170	COG1442	glycosyl transferase family 8
B2904_RS00170	COG1216	Glycosyl transferase, family 2
B2904_RS00195	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
B2904_RS00225	COG2252	PERMEase
B2904_RS00245	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
B2904_RS00255	COG1115	amino acid carrier protein
B2904_RS00260	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B2904_RS00265	COG0840	transmembrane signaling receptor activity
B2904_RS00275	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B2904_RS00285	COG0544	peptidyl-prolyl cis-trans isomerase activity
B2904_RS00290	COG0740	serine-type endopeptidase activity
B2904_RS00305	COG1702	phosphate starvation-inducible protein PhoH
B2904_RS00315	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B2904_RS00325	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B2904_RS00345	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B2904_RS00350	COG0228	four-way junction DNA binding
B2904_RS00365	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B2904_RS00380	COG0606	chelatase, subunit chli
B2904_RS00395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2904_RS00405	COG0765	amino acid transport
B2904_RS00410	COG1126	abc transporter atp-binding protein
B2904_RS00415	COG0708	Exodeoxyribonuclease III
B2904_RS00445	COG0709	Synthesizes selenophosphate from selenide and ATP
B2904_RS00450	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B2904_RS00455	COG0577	efflux transmembrane transporter activity
B2904_RS00455	COG1136	(ABC) transporter
B2904_RS00470	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B2904_RS00475	COG0681	Belongs to the peptidase S26 family
B2904_RS00485	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B2904_RS00500	COG0523	cobalamin synthesis protein
B2904_RS00505	COG0210	DNA helicase
B2904_RS00515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B2904_RS00570	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
B2904_RS00580	COG0463	Glycosyl transferase, family 2
B2904_RS00610	COG2201	protein-glutamate methylesterase activity
B2904_RS00615	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B2904_RS00620	COG5278	phosphoserine phosphatase activity
B2904_RS00620	COG0840	transmembrane signaling receptor activity
B2904_RS00630	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B2904_RS00635	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B2904_RS00640	COG3676	manually curated
B2904_RS00910	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B2904_RS00915	COG4166	transmembrane transport
B2904_RS00925	COG1030	water channel activity
B2904_RS00935	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B2904_RS00955	COG1309	transcriptional regulator
B2904_RS00970	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B2904_RS00980	COG2084	Dehydrogenase
B2904_RS00990	COG1501	Belongs to the glycosyl hydrolase 31 family
B2904_RS01000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B2904_RS01005	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B2904_RS01010	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B2904_RS01025	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B2904_RS01030	COG1132	(ABC) transporter
B2904_RS01035	COG4988	ABC transporter
B2904_RS01050	COG2832	Protein of unknown function (DUF454)
B2904_RS01060	COG0151	Belongs to the GarS family
B2904_RS01095	COG2832	Protein of unknown function (DUF454)
B2904_RS01115	COG0018	arginyl-trna synthetase
B2904_RS01120	COG0037	tRNA processing
B2904_RS01160	COG0714	Associated with various cellular activities
B2904_RS01175	COG0357	Ribosomal RNA small subunit methyltransferase G
B2904_RS01185	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B2904_RS01195	COG0714	Associated with various cellular activities
B2904_RS01210	COG1757	Na H antiporter
B2904_RS01225	COG3959	Transketolase, thiamine diphosphate binding domain
B2904_RS01230	COG3958	Transketolase
B2904_RS01250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B2904_RS01255	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B2904_RS01280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B2904_RS01280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B2904_RS01280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B2904_RS01285	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B2904_RS01290	COG1349	DNA-binding transcription factor activity
B2904_RS01325	COG1605	Chorismate mutase
B2904_RS01325	COG0077	Prephenate dehydratase
B2904_RS01335	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B2904_RS01340	COG0167	dihydroorotate dehydrogenase activity
B2904_RS01345	COG0543	2 iron, 2 sulfur cluster binding
B2904_RS01375	COG0215	cysteine-tRNA ligase activity
B2904_RS01390	COG0714	Associated with various cellular activities
B2904_RS01405	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B2904_RS01420	COG2201	protein-glutamate methylesterase activity
B2904_RS01445	COG1792	Involved in formation and maintenance of cell shape
B2904_RS01455	COG4956	integral membrane protein (PIN domain superfamily)
B2904_RS01460	COG1329	Transcriptional regulator
B2904_RS01465	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B2904_RS01470	COG1477	protein flavinylation
B2904_RS01480	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B2904_RS01485	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B2904_RS01490	COG2086	electron transfer activity
B2904_RS01495	COG1960	acyl-CoA dehydrogenase activity
B2904_RS01500	COG2030	dehydratase
B2904_RS01515	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
B2904_RS01525	COG1394	ATPase activity, coupled to movement of substances
B2904_RS01530	COG1269	ATP hydrolysis coupled proton transport
B2904_RS01545	COG1263	PTS System
B2904_RS01545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B2904_RS01550	COG2723	6-phospho-beta-galactosidase activity
B2904_RS01585	COG1940	carbohydrate kinase activity
B2904_RS01595	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B2904_RS01600	COG0049	tRNA binding
B2904_RS01605	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B2904_RS01610	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B2904_RS01630	COG0089	rRNA binding
B2904_RS01640	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B2904_RS01645	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B2904_RS01650	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B2904_RS01655	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B2904_RS01660	COG0255	Belongs to the universal ribosomal protein uL29 family
B2904_RS01670	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B2904_RS01675	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B2904_RS01680	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B2904_RS01685	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B2904_RS01690	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B2904_RS01695	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B2904_RS01700	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B2904_RS01705	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B2904_RS01710	COG1841	ribosomal large subunit assembly
B2904_RS01715	COG0200	Binds to the 23S rRNA
B2904_RS01720	COG0201	protein transport
B2904_RS01725	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B2904_RS01730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B2904_RS01735	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B2904_RS01740	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B2904_RS01745	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B2904_RS01760	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B2904_RS01765	COG1193	negative regulation of DNA recombination
B2904_RS01770	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B2904_RS01785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B2904_RS01795	COG4770	biotin carboxylase activity
B2904_RS01800	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
B2904_RS01805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2904_RS01810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2904_RS01815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2904_RS01825	COG0343	queuine tRNA-ribosyltransferase activity
B2904_RS01830	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B2904_RS01840	COG0588	phosphoglycerate mutase activity
B2904_RS01850	COG0268	Binds directly to 16S ribosomal RNA
B2904_RS01860	COG1196	nuclear chromosome segregation
B2904_RS01865	COG0557	exoribonuclease II activity
B2904_RS01880	COG0446	pyridine nucleotide-disulphide oxidoreductase
B2904_RS01885	COG2358	TRAP transporter, solute receptor (TAXI family
B2904_RS01895	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B2904_RS01910	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B2904_RS01920	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B2904_RS01925	COG0436	Aminotransferase
B2904_RS01960	COG1609	Transcriptional regulator
B2904_RS01965	COG1263	PTS System
B2904_RS01965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B2904_RS01970	COG1621	beta-fructofuranosidase activity
B2904_RS01975	COG1516	flagellar protein fliS
B2904_RS01985	COG4232	protein-disulfide reductase activity
B2904_RS01990	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B2904_RS01995	COG0629	single-stranded DNA binding
B2904_RS02000	COG0360	Binds together with S18 to 16S ribosomal RNA
B2904_RS02010	COG1040	competence protein
B2904_RS02015	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B2904_RS02020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B2904_RS02020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B2904_RS02020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B2904_RS02065	COG0527	aspartate kinase activity
B2904_RS02100	COG0674	pyruvate-flavodoxin oxidoreductase activity
B2904_RS02110	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B2904_RS02110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B2904_RS02135	COG2226	methyltransferase
B2904_RS02140	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
B2904_RS02145	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B2904_RS02205	COG1131	(ABC) transporter
B2904_RS02250	COG1136	(ABC) transporter
B2904_RS02275	COG2239	Acts as a magnesium transporter
B2904_RS02280	COG0205	6-phosphofructokinase activity
B2904_RS02295	COG5278	phosphoserine phosphatase activity
B2904_RS02295	COG0840	transmembrane signaling receptor activity
B2904_RS02310	COG0574	Belongs to the PEP-utilizing enzyme family
B2904_RS02310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B2904_RS02330	COG1022	Amp-dependent synthetase and ligase
B2904_RS02335	COG0656	L-ascorbic acid biosynthetic process
B2904_RS02355	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B2904_RS02365	COG0500	methyltransferase
B2904_RS02375	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B2904_RS02375	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B2904_RS02390	COG2814	Major facilitator Superfamily
B2904_RS02400	COG4166	transmembrane transport
B2904_RS02410	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
B2904_RS02425	COG1979	alcohol dehydrogenase
B2904_RS02430	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B2904_RS02440	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
B2904_RS02470	COG0330	HflC and HflK could
B2904_RS02475	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B2904_RS02480	COG0739	heme binding
B2904_RS02485	COG2255	four-way junction helicase activity
B2904_RS02495	COG0557	exoribonuclease II activity
B2904_RS02505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B2904_RS02515	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B2904_RS02515	COG0517	IMP dehydrogenase activity
B2904_RS02520	COG0792	nuclease activity
B2904_RS02560	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B2904_RS02565	COG1592	Rubrerythrin
B2904_RS02570	COG2962	Rard protein
B2904_RS02575	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B2904_RS02590	COG0569	domain protein
B2904_RS02600	COG4221	oxidoreductase activity
B2904_RS02610	COG1560	Kdo2-lipid A biosynthetic process
B2904_RS02615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B2904_RS02620	COG0101	tRNA pseudouridine synthase activity
B2904_RS02625	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B2904_RS02630	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B2904_RS02645	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B2904_RS02650	COG0745	RESPONSE REGULATOR receiver
B2904_RS02690	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B2904_RS02735	COG2738	Putative neutral zinc metallopeptidase
B2904_RS02745	COG1151	hydroxylamine reductase activity
B2904_RS02750	COG1959	2 iron, 2 sulfur cluster binding
B2904_RS02755	COG0482	sulfurtransferase activity
B2904_RS02770	COG2195	Cleaves the N-terminal amino acid of tripeptides
B2904_RS02775	COG1442	glycosyl transferase family 8
B2904_RS02775	COG1216	Glycosyl transferase, family 2
B2904_RS02795	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B2904_RS02815	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B2904_RS02835	COG2890	protein-(glutamine-N5) methyltransferase activity
B2904_RS02850	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B2904_RS02855	COG0673	inositol 2-dehydrogenase activity
B2904_RS02875	COG1528	Iron-storage protein
B2904_RS02880	COG1137	ATPase activity
B2904_RS02890	COG0537	adenosine 5'-monophosphoramidase activity
B2904_RS02935	COG1426	Protein conserved in bacteria
B2904_RS02945	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B2904_RS02950	COG1595	DNA-templated transcription, initiation
B2904_RS02970	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B2904_RS02975	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
B2904_RS02980	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
B2904_RS02985	COG1744	ABC transporter substrate-binding protein PnrA-like
B2904_RS02990	COG1744	ABC transporter substrate-binding protein PnrA-like
B2904_RS02995	COG3845	ABC transporter
B2904_RS03005	COG1079	Belongs to the binding-protein-dependent transport system permease family
B2904_RS03010	COG0561	phosphatase activity
B2904_RS03015	COG0561	phosphatase activity
B2904_RS03035	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
B2904_RS03040	COG1562	ergosterol biosynthetic process
B2904_RS03045	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B2904_RS03060	COG1309	transcriptional regulator
B2904_RS03075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B2904_RS03075	COG0072	phenylalanine-tRNA ligase activity
B2904_RS03080	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B2904_RS03085	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B2904_RS03095	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
B2904_RS03110	COG4232	protein-disulfide reductase activity
B2904_RS03160	COG0525	valine-tRNA ligase activity
B2904_RS03185	COG4166	transmembrane transport
B2904_RS03190	COG1473	amidohydrolase
B2904_RS03195	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B2904_RS03230	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
B2904_RS03235	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
B2904_RS03250	COG1115	amino acid carrier protein
B2904_RS03255	COG1115	amino acid carrier protein
B2904_RS03265	COG0012	GTP binding
B2904_RS03275	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
B2904_RS03285	COG3681	Belongs to the UPF0597 family
B2904_RS03315	COG0519	Catalyzes the synthesis of GMP from XMP
B2904_RS03320	COG1283	sodium-dependent phosphate transmembrane transporter activity
B2904_RS03350	COG0667	Aldo Keto reductase
B2904_RS03360	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B2904_RS03370	COG0824	Thioesterase
B2904_RS03385	COG0835	chemotaxis
B2904_RS03415	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B2904_RS03425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B2904_RS03430	COG0398	Pfam SNARE associated Golgi protein
B2904_RS03435	COG0398	Pfam SNARE associated Golgi protein
B2904_RS03470	COG2897	thiosulfate sulfurtransferase activity
B2904_RS03490	COG1366	Belongs to the anti-sigma-factor antagonist family
B2904_RS03510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B2904_RS03515	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
B2904_RS03520	COG3835	regulator
B2904_RS03525	COG2610	gluconate transmembrane transporter activity
B2904_RS03530	COG1929	Belongs to the glycerate kinase type-1 family
B2904_RS03535	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B2904_RS03570	COG0285	dihydrofolate synthase activity
B2904_RS03575	COG0789	Transcriptional regulator
B2904_RS03585	COG0656	L-ascorbic acid biosynthetic process
B2904_RS03590	COG0667	Aldo Keto reductase
B2904_RS03635	COG1028	Short-chain dehydrogenase reductase Sdr
B2904_RS03650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B2904_RS03650	COG1522	sequence-specific DNA binding
B2904_RS03655	COG0671	phosphoesterase, PA-phosphatase related
B2904_RS03670	COG4166	transmembrane transport
B2904_RS03685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B2904_RS03710	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B2904_RS03715	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B2904_RS03725	COG0443	Heat shock 70 kDa protein
B2904_RS03735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B2904_RS03745	COG0352	thiamine-phosphate diphosphorylase activity
B2904_RS03770	COG0463	Glycosyl transferase, family 2
B2904_RS03815	COG4864	UPF0365 protein
B2904_RS03830	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B2904_RS03840	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B2904_RS03845	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B2904_RS03850	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B2904_RS03860	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B2904_RS03865	COG0356	it plays a direct role in the translocation of protons across the membrane
B2904_RS03870	COG1366	Belongs to the anti-sigma-factor antagonist family
B2904_RS03875	COG0737	Belongs to the 5'-nucleotidase family
B2904_RS03890	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B2904_RS03930	COG4191	Histidine kinase
B2904_RS03940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B2904_RS03955	COG0237	dephospho-CoA kinase activity
B2904_RS03980	COG1181	Belongs to the D-alanine--D-alanine ligase family
B2904_RS04025	COG0469	pyruvate kinase activity
B2904_RS04030	COG1028	Short-chain dehydrogenase reductase Sdr
B2904_RS04035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B2904_RS04055	COG1652	LysM domain
B2904_RS04055	COG1652	LysM domain
B2904_RS04080	COG0233	cytoplasmic translational termination
B2904_RS04090	COG0575	Belongs to the CDS family
B2904_RS04110	COG1666	GTP binding
B2904_RS04115	COG0297	glycogen (starch) synthase activity
B2904_RS04125	COG1164	Oligoendopeptidase f
B2904_RS04135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B2904_RS04135	COG1263	PTS System
B2904_RS04140	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B2904_RS04150	COG3676	manually curated
B2904_RS04155	COG3340	Belongs to the peptidase S51 family
B2904_RS04185	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B2904_RS04190	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B2904_RS04195	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B2904_RS04215	COG0385	Bile acid
B2904_RS04220	COG0129	dihydroxy-acid dehydratase activity
B2904_RS04225	COG1528	Iron-storage protein
B2904_RS04235	COG1233	COG1233 Phytoene dehydrogenase and related
B2904_RS04255	COG0840	transmembrane signaling receptor activity
B2904_RS04275	COG4175	Glycine betaine
B2904_RS04280	COG1482	cell wall glycoprotein biosynthetic process
B2904_RS04290	COG0495	leucyl-tRNA aminoacylation
B2904_RS04315	COG4166	transmembrane transport
B2904_RS04320	COG1064	alcohol dehydrogenase
B2904_RS04325	COG4166	transmembrane transport
B2904_RS04345	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B2904_RS04365	COG3250	beta-galactosidase activity
B2904_RS04370	COG2211	Major facilitator Superfamily
B2904_RS04375	COG0246	Mannitol dehydrogenase
B2904_RS04380	COG1312	Catalyzes the dehydration of D-mannonate
B2904_RS04385	COG1904	glucuronate isomerase
B2904_RS04390	COG0800	Aldolase
B2904_RS04400	COG3956	TIGRFAM MazG family protein
B2904_RS04405	COG0628	permease
B2904_RS04415	COG2843	Capsule synthesis protein
B2904_RS04420	COG4536	flavin adenine dinucleotide binding
B2904_RS04460	COG0745	RESPONSE REGULATOR receiver
B2904_RS04465	COG0643	Histidine kinase
B2904_RS04465	COG2198	Histidine kinase
B2904_RS04480	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B2904_RS04485	COG2201	protein-glutamate methylesterase activity
B2904_RS04495	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B2904_RS04505	COG3842	ATPase activity
B2904_RS04520	COG1760	l-serine dehydratase
B2904_RS04545	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B2904_RS04555	COG0745	RESPONSE REGULATOR receiver
B2904_RS04560	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
B2904_RS04560	COG0493	'glutamate synthase
B2904_RS04590	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B2904_RS04595	COG2964	Protein conserved in bacteria
B2904_RS04600	COG1301	dicarboxylic acid transport
B2904_RS04630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B2904_RS04635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B2904_RS04655	COG0142	geranyltranstransferase activity
B2904_RS04680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B2904_RS04745	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B2904_RS04750	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B2904_RS04750	COG0321	lipoyl(octanoyl) transferase activity
B2904_RS04755	COG1263	PTS System
B2904_RS04755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B2904_RS04760	COG0517	IMP dehydrogenase activity
B2904_RS04760	COG0516	GMP reductase activity
B2904_RS04765	COG0126	phosphoglycerate kinase activity
B2904_RS04770	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B2904_RS04790	COG0799	negative regulation of ribosome biogenesis
B2904_RS04810	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B2904_RS04815	COG3263	regulation of cellular component size
B2904_RS04820	COG0459	protein refolding
B2904_RS04835	COG1418	mRNA catabolic process
B2904_RS04840	COG1692	metallophosphoesterase
B2904_RS04855	COG1713	HD superfamily hydrolase involved in NAD metabolism
B2904_RS04860	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B2904_RS04865	COG0442	prolyl-tRNA aminoacylation
B2904_RS04890	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B2904_RS04900	COG0646	methionine synthase
B2904_RS04900	COG1410	methionine synthase
B2904_RS04920	COG0561	phosphatase activity
B2904_RS04935	COG3623	hexulose-6-phosphate isomerase
B2904_RS04985	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B2904_RS04990	COG0538	isocitrate dehydrogenase activity
B2904_RS04995	COG0372	Belongs to the citrate synthase family
B2904_RS05010	COG4974	Belongs to the 'phage' integrase family
B2904_RS05015	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B2904_RS05045	COG2949	membrane
B2904_RS05055	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B2904_RS05055	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B2904_RS05090	COG0601	transmembrane transport
B2904_RS05095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B2904_RS05100	COG0444	Belongs to the ABC transporter superfamily
B2904_RS05105	COG4608	Belongs to the ABC transporter superfamily
B2904_RS05140	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B2904_RS05165	COG0673	inositol 2-dehydrogenase activity
B2904_RS05175	COG1199	ATP-dependent helicase activity
B2904_RS05185	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B2904_RS05200	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B2904_RS05245	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B2904_RS05250	COG0280	phosphate acetyltransferase
B2904_RS05265	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B2904_RS05270	COG1053	succinate dehydrogenase
B2904_RS05275	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B2904_RS05290	COG1486	melibiose metabolic process
B2904_RS05295	COG1263	PTS System
B2904_RS05295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B2904_RS05295	COG2190	(PTS) system
B2904_RS05300	COG0730	response to heat
B2904_RS05310	COG1338	Plays a role in the flagellum-specific transport system
B2904_RS05315	COG1987	bacterial-type flagellum assembly
B2904_RS05320	COG1684	flagellar biosynthetic protein fliR
B2904_RS05330	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B2904_RS05350	COG1191	sigma factor activity
B2904_RS05380	COG1253	flavin adenine dinucleotide binding
B2904_RS05385	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B2904_RS05400	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B2904_RS05415	COG0813	purine-nucleoside phosphorylase activity
B2904_RS05420	COG1012	belongs to the aldehyde dehydrogenase family
B2904_RS05425	COG2385	sporulation resulting in formation of a cellular spore
B2904_RS05430	COG1649	PFAM Uncharacterised BCR, COG1649
B2904_RS05440	COG0124	histidyl-tRNA synthetase
B2904_RS05455	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B2904_RS05475	COG1595	DNA-templated transcription, initiation
B2904_RS05485	COG2205	protein histidine kinase activity
B2904_RS05485	COG0784	Response regulator, receiver
B2904_RS05515	COG0519	Catalyzes the synthesis of GMP from XMP
B2904_RS05515	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B2904_RS05530	COG0371	Dehydrogenase
B2904_RS05540	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B2904_RS05555	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B2904_RS05560	COG2183	response to ionizing radiation
B2904_RS05560	COG0539	negative regulation of cytoplasmic translation
B2904_RS05565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B2904_RS05570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B2904_RS05575	COG1120	ATPase activity
B2904_RS05595	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B2904_RS05600	COG2011	ABC-type metal ion transport system permease component
B2904_RS05610	COG1464	Belongs to the NlpA lipoprotein family
B2904_RS05615	COG1464	Belongs to the NlpA lipoprotein family
B2904_RS05645	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B2904_RS05655	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
B2904_RS05660	COG0840	transmembrane signaling receptor activity
B2904_RS05665	COG1214	PFAM Peptidase M22, glycoprotease
B2904_RS05675	COG0733	neurotransmitter:sodium symporter activity
B2904_RS05685	COG0640	Transcriptional regulator
B2904_RS05690	COG2217	Heavy metal translocating P-type atpase
B2904_RS05695	COG0668	transmembrane transport
B2904_RS05715	COG1192	Involved in chromosome partitioning
B2904_RS05725	COG0739	heme binding
B2904_RS05735	COG0739	heme binding
B2904_RS05745	COG0359	binds to the 23S rRNA
B2904_RS05750	COG0305	Participates in initiation and elongation during chromosome replication
B2904_RS05765	COG2877	3-deoxy-8-phosphooctulonate synthase activity
B2904_RS05775	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B2904_RS05805	COG0180	Tryptophanyl-tRNA synthetase
B2904_RS05815	COG0811	peptide transport
B2904_RS05830	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B2904_RS05835	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
B2904_RS05845	COG2373	Large extracellular alpha-helical protein
B2904_RS05865	COG3706	GGDEF domain
B2904_RS05885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B2904_RS05900	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B2904_RS05910	COG0772	Belongs to the SEDS family
B2904_RS05915	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B2904_RS05920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B2904_RS05940	COG0563	adenylate kinase activity
B2904_RS05945	COG2309	aminopeptidase activity
B2904_RS05950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B2904_RS05980	COG1063	alcohol dehydrogenase
B2904_RS05985	COG1028	Short-chain dehydrogenase reductase Sdr
B2904_RS06000	COG1172	Belongs to the binding-protein-dependent transport system permease family
B2904_RS06005	COG0534	Mate efflux family protein
B2904_RS06010	COG0133	tryptophan synthase activity
B2904_RS06030	COG4608	Belongs to the ABC transporter superfamily
B2904_RS06035	COG0444	Belongs to the ABC transporter superfamily
B2904_RS06050	COG1902	pentaerythritol trinitrate reductase activity
B2904_RS06055	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B2904_RS06060	COG1132	(ABC) transporter
B2904_RS06075	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B2904_RS06160	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B2904_RS06165	COG0594	ribonuclease P activity
B2904_RS06175	COG0706	membrane insertase activity
B2904_RS06180	COG1847	R3H domain protein
B2904_RS06220	COG0484	heat shock protein binding
B2904_RS06225	COG0484	heat shock protein binding
B2904_RS06275	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
B2904_RS06280	COG0697	spore germination
B2904_RS06290	COG2239	Acts as a magnesium transporter
B2904_RS06310	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B2904_RS06320	COG3872	metal-dependent enzyme
B2904_RS06330	COG0463	Glycosyl transferase, family 2
B2904_RS06345	COG5016	pyruvate
B2904_RS06345	COG0511	ligase activity, forming carbon-carbon bonds
B2904_RS06355	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B2904_RS06360	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B2904_RS06365	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
B2904_RS06395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B2904_RS06400	COG1473	amidohydrolase
B2904_RS06410	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B2904_RS06415	COG0460	homoserine dehydrogenase
B2904_RS06420	COG0564	pseudouridine synthase activity
B2904_RS06440	COG1254	Belongs to the acylphosphatase family
B2904_RS06475	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B2904_RS06475	COG0352	thiamine-phosphate diphosphorylase activity
B2904_RS06475	COG0351	phosphomethylpyrimidine kinase
B2904_RS06495	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B2904_RS06500	COG0756	dUTP diphosphatase activity
B2904_RS06505	COG2610	gluconate transmembrane transporter activity
B2904_RS06525	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B2904_RS06540	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B2904_RS06570	COG2264	protein methyltransferase activity
B2904_RS06580	COG2204	response regulator
B2904_RS06585	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B2904_RS06595	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B2904_RS06645	COG0848	biopolymer transport protein
B2904_RS06655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B2904_RS06665	COG0540	Belongs to the ATCase OTCase family
B2904_RS06675	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B2904_RS06690	COG1966	Carbon starvation protein
B2904_RS06705	COG0859	PFAM glycosyl transferase family 9
B2904_RS06710	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B2904_RS06715	COG2267	carboxylic ester hydrolase activity
B2904_RS06755	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B2904_RS06765	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B2904_RS06775	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
B2904_RS06790	COG1129	ABC transporter
B2904_RS06795	COG1070	Carbohydrate kinase
B2904_RS06800	COG0235	Class ii aldolase
B2904_RS06805	COG1454	alcohol dehydrogenase
B2904_RS06810	COG1609	Transcriptional regulator
B2904_RS06815	COG0741	lytic transglycosylase activity
B2904_RS06835	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B2904_RS06855	COG0019	diaminopimelate decarboxylase activity
B2904_RS06870	COG0745	RESPONSE REGULATOR receiver
B2904_RS06915	COG4149	molybdate abc transporter
B2904_RS06920	COG0725	ABC transporter, periplasmic molybdate-binding protein
B2904_RS06925	COG0521	Mo-molybdopterin cofactor biosynthetic process
B2904_RS06995	COG4232	protein-disulfide reductase activity
B2904_RS07015	COG0698	ribose 5-phosphate isomerase
B2904_RS07025	COG1496	oxidoreductase activity
B2904_RS07035	COG0473	3-isopropylmalate dehydrogenase activity
B2904_RS07040	COG0066	3-isopropylmalate dehydratase activity
B2904_RS07045	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B2904_RS07050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B2904_RS07055	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B2904_RS07060	COG0440	acetolactate synthase activity
B2904_RS07065	COG0028	Belongs to the TPP enzyme family
B2904_RS07075	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B2904_RS07095	COG2304	oxidoreductase activity
B2904_RS07105	COG0488	(ABC) transporter
B2904_RS07110	COG0446	pyridine nucleotide-disulphide oxidoreductase
B2904_RS07115	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B2904_RS07120	COG4166	transmembrane transport
B2904_RS07145	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B2904_RS07155	COG1811	Na channel or pump
B2904_RS07205	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B2904_RS07230	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B2904_RS07235	COG0697	spore germination
B2904_RS07245	COG1959	2 iron, 2 sulfur cluster binding
B2904_RS07260	COG2910	NAD(P)H-binding
B2904_RS07265	COG0653	protein targeting
B2904_RS07285	COG1136	(ABC) transporter
B2904_RS07315	COG0393	Putative heavy-metal-binding
B2904_RS07335	COG0052	Belongs to the universal ribosomal protein uS2 family
B2904_RS07345	COG1045	serine acetyltransferase
B2904_RS07350	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B2904_RS07370	COG1449	Belongs to the glycosyl hydrolase 57 family
B2904_RS07380	COG1609	Transcriptional regulator
B2904_RS07395	COG1486	melibiose metabolic process
B2904_RS07400	COG0083	homoserine kinase activity
B2904_RS07405	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B2904_RS07435	COG0405	Gamma-glutamyltransferase
B2904_RS07445	COG0436	Aminotransferase
B2904_RS07475	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B2904_RS07480	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B2904_RS07485	COG0704	Plays a role in the regulation of phosphate uptake
B2904_RS07490	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B2904_RS07495	COG0573	inorganic phosphate transmembrane transporter activity
B2904_RS07500	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B2904_RS07510	COG0753	catalase activity
B2904_RS07530	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B2904_RS07550	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B2904_RS07560	COG1695	Transcriptional regulator
B2904_RS07565	COG2223	nitrite transmembrane transporter activity
B2904_RS07600	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B2904_RS07605	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B2904_RS07610	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B2904_RS07625	COG1131	(ABC) transporter
B2904_RS07645	COG1363	Peptidase, m42
B2904_RS07680	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B2904_RS07695	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
B2904_RS07695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B2904_RS07705	COG1335	isochorismatase
B2904_RS07710	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B2904_RS07715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B2904_RS07735	COG1921	L-seryl-tRNASec selenium transferase activity
B2904_RS07745	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B2904_RS07780	COG0561	phosphatase activity
B2904_RS07785	COG0561	phosphatase activity
B2904_RS07810	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B2904_RS07820	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B2904_RS07855	COG0312	modulator of DNA gyrase
B2904_RS07865	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B2904_RS07880	COG1131	(ABC) transporter
B2904_RS07895	COG1162	GTPase activity
B2904_RS07930	COG1598	PFAM Uncharacterised protein family UPF0150
B2904_RS07935	COG0071	Belongs to the small heat shock protein (HSP20) family
B2904_RS07945	COG1970	mechanosensitive ion channel activity
B2904_RS07950	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B2904_RS07955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B2904_RS07960	COG0560	Phosphoserine phosphatase
B2904_RS07970	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B2904_RS07985	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
B2904_RS07995	COG0768	penicillin binding
B2904_RS08030	COG0835	chemotaxis
B2904_RS08045	COG0328	RNA-DNA hybrid ribonuclease activity
B2904_RS08090	COG2313	pseudouridylate synthase activity
B2904_RS08105	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B2904_RS08145	COG1032	radical SAM domain protein
B2904_RS08150	COG1917	Cupin 2, conserved barrel domain protein
B2904_RS08165	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B2904_RS08175	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B2904_RS08180	COG0656	L-ascorbic acid biosynthetic process
B2904_RS08190	COG0542	response to heat
B2904_RS08215	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
B2904_RS08220	COG3314	Sporulation integral membrane protein YlbJ
B2904_RS08230	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B2904_RS08235	COG0616	signal peptide processing
B2904_RS08260	COG0741	lytic transglycosylase activity
B2904_RS08270	COG1157	protein secretion by the type III secretion system
B2904_RS08285	COG1766	The M ring may be actively involved in energy transduction
B2904_RS08290	COG1058	Belongs to the CinA family
B2904_RS08290	COG1546	Belongs to the CinA family
B2904_RS08295	COG1687	branched-chain amino acid
B2904_RS08300	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
B2904_RS08305	COG3142	Participates in the control of copper homeostasis
B2904_RS08310	COG3676	manually curated
B2904_RS08325	COG0386	Belongs to the glutathione peroxidase family
B2904_RS08335	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
B2904_RS08350	COG0275	rRNA processing
B2904_RS08355	COG0556	nucleotide-excision repair
B2904_RS08360	COG0534	Mate efflux family protein
B2904_RS08380	COG0456	acetyltransferase
B2904_RS08430	COG0358	DNA primase activity
B2904_RS08440	COG1022	Amp-dependent synthetase and ligase
B2904_RS08455	COG0701	Predicted permease
B2904_RS08475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B2904_RS08500	COG0187	DNA topoisomerase II activity
B2904_RS08525	COG0551	DNA topoisomerase type I activity
B2904_RS08525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B2904_RS08530	COG0758	DNA mediated transformation
B2904_RS08530	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B2904_RS08560	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
B2904_RS08575	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B2904_RS08595	COG0534	Mate efflux family protein
B2904_RS08605	COG0297	glycogen (starch) synthase activity
B2904_RS08630	COG2195	Cleaves the N-terminal amino acid of tripeptides
B2904_RS08655	COG4953	penicillin-binding protein 1C
B2904_RS08665	COG1309	transcriptional regulator
B2904_RS08690	COG0564	pseudouridine synthase activity
B2904_RS08695	COG0717	Belongs to the dCTP deaminase family
B2904_RS08725	COG0488	(ABC) transporter
B2904_RS08735	COG0504	CTP synthase activity
B2904_RS08750	COG1216	Glycosyl transferase, family 2
B2904_RS08750	COG1442	glycosyl transferase family 8
B2904_RS08755	COG1773	rubredoxin
B2904_RS08765	COG1121	(ABC) transporter
B2904_RS08775	COG0481	GTPase activity
B2904_RS08795	COG3676	manually curated
B2904_RS08820	COG2017	converts alpha-aldose to the beta-anomer
B2904_RS08825	COG0751	glycine-tRNA ligase activity
B2904_RS08855	COG0497	DNA recombination
B2904_RS08875	COG0588	phosphoglycerate mutase activity
B2904_RS08895	COG0629	single-stranded DNA binding
B2904_RS08900	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B2904_RS08915	COG0592	DNA-directed DNA polymerase activity
B2904_RS08940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B2904_RS08945	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B2904_RS08960	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B2904_RS08965	COG0416	fatty acid biosynthetic process
B2904_RS08970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B2904_RS08975	COG4656	Part of a membrane complex involved in electron transport
B2904_RS08980	COG4658	electron transport chain
B2904_RS08995	COG0666	response to abiotic stimulus
B2904_RS09015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B2904_RS09025	COG0254	rRNA binding
B2904_RS09035	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B2904_RS09050	COG1968	undecaprenyl-diphosphatase activity
B2904_RS09075	COG0251	oxidation-reduction process
B2904_RS09085	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B2904_RS09090	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B2904_RS09095	COG0193	aminoacyl-tRNA hydrolase activity
B2904_RS09100	COG0193	aminoacyl-tRNA hydrolase activity
B2904_RS09115	COG1263	PTS System
B2904_RS09115	COG2190	(PTS) system
B2904_RS09115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B2904_RS09120	COG2204	response regulator
B2904_RS09125	COG5002	protein histidine kinase activity
B2904_RS09130	COG0242	peptide deformylase activity
B2904_RS09135	COG0546	phosphoglycolate phosphatase activity
B2904_RS09140	COG4166	transmembrane transport
B2904_RS09150	COG0741	lytic transglycosylase activity
B2904_RS09150	COG0739	heme binding
B2904_RS09150	COG1196	nuclear chromosome segregation
B2904_RS09155	COG0582	viral genome integration into host DNA
B2904_RS09190	COG3179	chitinase
B2904_RS09295	COG4626	Terminase
B2904_RS09295	COG1802	Transcriptional regulator
B2904_RS09430	COG1245	4Fe-4S binding domain
B2904_RS09430	COG2878	Part of a membrane complex involved in electron transport
B2904_RS09435	COG4657	Part of a membrane complex involved in electron transport
B2904_RS09455	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B2904_RS09460	COG0681	Belongs to the peptidase S26 family
B2904_RS09470	COG0456	acetyltransferase
B2904_RS09475	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B2904_RS09490	COG0840	transmembrane signaling receptor activity
B2904_RS09535	COG4206	TonB-dependent receptor
B2904_RS09535	COG4206	TonB-dependent receptor
B2904_RS09540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B2904_RS09550	COG0149	triose-phosphate isomerase activity
B2904_RS09555	COG1335	isochorismatase
B2904_RS09605	COG0432	Pfam Uncharacterised protein family UPF0047
B2904_RS09645	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B2904_RS09655	COG1757	Na H antiporter
B2904_RS09665	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B2904_RS09685	COG2217	Heavy metal translocating P-type atpase
B2904_RS09690	COG0632	four-way junction helicase activity
B2904_RS09710	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B2904_RS09720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B2904_RS09725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B2904_RS09735	COG1785	Belongs to the alkaline phosphatase family
B2904_RS09790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B2904_RS09805	COG1250	3-hydroxyacyl-CoA dehydrogenase
B2904_RS09810	COG1024	Enoyl-CoA hydratase
B2904_RS09815	COG0183	Belongs to the thiolase family
B2904_RS09830	COG0427	acetyl-CoA hydrolase
B2904_RS09845	COG0426	domain, Protein
B2904_RS09885	COG0549	Belongs to the carbamate kinase family
B2904_RS09890	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B2904_RS09895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B2904_RS09920	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B2904_RS09950	COG1104	cysteine desulfurase activity
B2904_RS09955	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
B2904_RS09970	COG3676	manually curated
B2904_RS10010	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B2904_RS10050	COG1064	alcohol dehydrogenase
B2904_RS10085	COG0697	spore germination
B2904_RS10115	COG1360	Flagellar Motor Protein
B2904_RS10120	COG0116	Belongs to the methyltransferase superfamily
B2904_RS10120	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B2904_RS10135	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B2904_RS10145	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B2904_RS10150	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B2904_RS10155	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B2904_RS10160	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
B2904_RS10175	COG3853	Toxic anion resistance protein (TelA)
B2904_RS10210	COG1187	pseudouridine synthase activity
B2904_RS10220	COG1454	alcohol dehydrogenase
B2904_RS10225	COG4452	Inner membrane protein CreD
B2904_RS10230	COG3676	manually curated
B2904_RS10240	COG0534	Mate efflux family protein
B2904_RS10260	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B2904_RS10265	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B2904_RS10285	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B2904_RS10290	COG1592	Rubrerythrin
B2904_RS10295	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B2904_RS10300	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B2904_RS10305	COG0579	oxidoreductase
B2904_RS10310	COG0446	pyridine nucleotide-disulphide oxidoreductase
B2904_RS10330	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B2904_RS10335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B2904_RS10340	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B2904_RS10355	COG4166	transmembrane transport
B2904_RS10360	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B2904_RS10385	COG0492	ferredoxin-NADP+ reductase activity
B2904_RS10420	COG0681	Belongs to the peptidase S26 family
B2904_RS10455	COG2759	Belongs to the formate--tetrahydrofolate ligase family
B2904_RS10460	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B2904_RS10460	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B2904_RS10465	COG0534	Mate efflux family protein
B2904_RS10470	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B2904_RS10535	COG1872	DUF167
B2904_RS10550	COG2703	oxygen carrier activity
B2904_RS10570	COG1012	belongs to the aldehyde dehydrogenase family
B2904_RS10570	COG1454	alcohol dehydrogenase
B2904_RS10575	COG0752	glycyl-tRNA synthetase alpha subunit
B2904_RS10595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B2904_RS10615	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B2904_RS10620	COG1177	transmembrane transport
B2904_RS10625	COG1176	ABC-type spermidine putrescine transport system, permease component I
B2904_RS10640	COG0534	Mate efflux family protein
B2904_RS10670	COG1473	amidohydrolase
B2904_RS10690	COG0745	RESPONSE REGULATOR receiver
B2904_RS10695	COG0772	Belongs to the SEDS family
B2904_RS10700	COG0768	penicillin binding
B2904_RS10705	COG0793	Belongs to the peptidase S41A family
B2904_RS10705	COG3409	Peptidoglycan-binding domain 1 protein
B2904_RS10710	COG1388	LysM domain
B2904_RS10710	COG0860	N-Acetylmuramoyl-L-alanine amidase
B2904_RS10720	COG0463	Glycosyl transferase, family 2
B2904_RS10725	COG2059	Chromate
B2904_RS10745	COG0281	malic enzyme
B2904_RS10745	COG0280	phosphate acetyltransferase
B2904_RS10755	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B2904_RS10780	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B2904_RS10785	COG4211	Belongs to the binding-protein-dependent transport system permease family
B2904_RS10790	COG1129	ABC transporter
B2904_RS10795	COG1879	ABC-type sugar transport system periplasmic component
B2904_RS10805	COG0564	pseudouridine synthase activity
B2904_RS10810	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B2904_RS10815	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B2904_RS10820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B2904_RS10830	COG3869	Catalyzes the specific phosphorylation of arginine residues in
B2904_RS10845	COG0335	large ribosomal subunit rRNA binding
B2904_RS10865	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B2904_RS10890	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B2904_RS10895	COG0577	efflux transmembrane transporter activity
B2904_RS10895	COG1136	(ABC) transporter
B2904_RS10905	COG0612	Peptidase, M16
B2904_RS10915	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B2904_RS10930	COG0432	Pfam Uncharacterised protein family UPF0047
B2904_RS10960	COG1580	Controls the rotational direction of flagella during chemotaxis
B2904_RS10965	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B2904_RS10970	COG1776	CheC inhibitor of MCP methylation
B2904_RS10970	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B2904_RS10980	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B2904_RS10980	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B2904_RS10995	COG1304	FMN binding
B2904_RS11000	COG1447	Phosphotransferase system cellobiose-specific component IIA
B2904_RS11005	COG1486	melibiose metabolic process
B2904_RS11010	COG2723	6-phospho-beta-galactosidase activity
B2904_RS11015	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B2904_RS11030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B2904_RS11030	COG3711	transcriptional antiterminator
B2904_RS11040	COG1185	polyribonucleotide nucleotidyltransferase activity
B2904_RS11045	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B2904_RS11050	COG0196	riboflavin kinase activity
B2904_RS11065	COG0446	pyridine nucleotide-disulphide oxidoreductase
B2904_RS11085	COG0326	Molecular chaperone. Has ATPase activity
B2904_RS11105	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B2904_RS11120	COG1297	OPT oligopeptide transporter protein
B2904_RS11125	COG2195	Cleaves the N-terminal amino acid of tripeptides
B2904_RS11130	COG0191	fructose-bisphosphate aldolase activity
B2904_RS11160	COG0733	neurotransmitter:sodium symporter activity
B2904_RS11175	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B2904_RS11175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B2904_RS11175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B2904_RS11180	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B2904_RS11185	COG0482	sulfurtransferase activity
B2904_RS11190	COG2832	Protein of unknown function (DUF454)
B2904_RS11195	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B2904_RS11205	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B2904_RS11210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B2904_RS11220	COG0179	Fumarylacetoacetate (FAA) hydrolase
B2904_RS11260	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B2904_RS11275	COG3845	ABC transporter
B2904_RS11280	COG4603	Belongs to the binding-protein-dependent transport system permease family
B2904_RS11285	COG1079	Belongs to the binding-protein-dependent transport system permease family
B2904_RS11295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B2904_RS11305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B2904_RS11365	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
B2904_RS11370	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B2904_RS11375	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B2904_RS11380	COG0085	RNA polymerase activity
B2904_RS11385	COG0222	ribosome binding
B2904_RS11390	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B2904_RS11395	COG0081	regulation of translation
B2904_RS11400	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B2904_RS11405	COG0250	Participates in transcription elongation, termination and antitermination
B2904_RS11420	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B2904_RS11430	COG0351	phosphomethylpyrimidine kinase
B2904_RS11440	COG3191	aminopeptidase activity
B2904_RS11465	COG1434	Gram-negative-bacterium-type cell wall biogenesis
B2904_RS11470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B2904_RS11475	COG0863	Belongs to the N(4) N(6)-methyltransferase family
B2904_RS11480	COG0183	Belongs to the thiolase family
B2904_RS11505	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
B2904_RS11510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B2904_RS11520	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B2904_RS11525	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B2904_RS11535	COG0363	glucosamine-6-phosphate deaminase activity
B2904_RS11540	COG0246	Mannitol dehydrogenase
B2904_RS11550	COG0546	phosphoglycolate phosphatase activity
B2904_RS11560	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B2904_RS11605	COG0765	amino acid transport
B2904_RS11660	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B2904_RS11690	COG0750	zinc metalloprotease
B2904_RS11695	COG0346	lactoylglutathione lyase activity
B2904_RS11700	COG3552	Protein containing von Willebrand factor type A (VWA) domain
B2904_RS11725	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B2904_RS11735	COG1115	amino acid carrier protein
B2904_RS11810	COG0826	peptidase U32
B2904_RS11815	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B2904_RS11820	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B2904_RS11825	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B2904_RS11830	COG2723	6-phospho-beta-galactosidase activity
B2904_RS11835	COG1301	dicarboxylic acid transport
B2904_RS11840	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B2904_RS11860	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B2904_RS11890	COG0733	neurotransmitter:sodium symporter activity
B2904_RS11895	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B2904_RS11900	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B2904_RS11950	COG0336	Belongs to the RNA methyltransferase TrmD family
B2904_RS11985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B2904_RS11990	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
B2904_RS12030	COG1543	Belongs to the glycosyl hydrolase 57 family
B2904_RS12040	COG1401	restriction endodeoxyribonuclease activity
B2904_RS12055	COG2172	sigma factor antagonist activity
B2904_RS12065	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B2904_RS12110	COG0154	amidase activity
B2904_RS12125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B2904_RS12130	COG1028	Short-chain dehydrogenase reductase Sdr
B2904_RS12135	COG1442	glycosyl transferase family 8
B2904_RS12150	COG3676	manually curated
B2904_RS12210	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B2904_RS12220	COG0138	bifunctional purine biosynthesis protein purh
B2904_RS12270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B2904_RS12280	COG1815	bacterial-type flagellum-dependent cell motility
B2904_RS12305	COG0583	DNA-binding transcription factor activity
B2904_RS12320	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B2904_RS12325	COG3676	manually curated
B2904_RS12335	COG0710	3-dehydroquinate dehydratase activity
B2904_RS12340	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B2904_RS12370	COG0733	neurotransmitter:sodium symporter activity
B2904_RS12390	COG4166	transmembrane transport
B2904_RS12400	COG0693	protein deglycase activity
B2904_RS12405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B2904_RS12415	COG1187	pseudouridine synthase activity
B2904_RS12425	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B2904_RS12435	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B2904_RS12450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B2904_RS12460	COG2362	D-Aminopeptidase
B2904_RS12480	COG3023	N-Acetylmuramoyl-L-alanine amidase
B2904_RS12490	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B2904_RS12490	COG2199	diguanylate cyclase activity
B2904_RS12530	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
B2904_RS12535	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B2904_RS12555	COG0826	peptidase U32
B2904_RS12570	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B2904_RS12575	COG0217	transcriptional regulatory protein
B2904_RS12590	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B2904_RS12595	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B2904_RS12600	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B2904_RS12620	COG1172	Belongs to the binding-protein-dependent transport system permease family
B2904_RS12635	COG1940	carbohydrate kinase activity
B2904_RS12710	COG3179	chitinase
B2904_RS12770	COG3645	SOS response
B2904_RS12790	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B2904_RS12795	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids