locus-tag	class	description
F8237_RS00005	COG4106	trans-aconitate 2-methyltransferase activity
F8237_RS00045	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS00075	COG0513	Belongs to the DEAD box helicase family
F8237_RS00085	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F8237_RS00095	COG0316	Belongs to the HesB IscA family
F8237_RS00105	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F8237_RS00110	COG0719	Fe-S assembly protein
F8237_RS00115	COG0396	ATPase activity
F8237_RS00120	COG0719	Fe-S assembly protein
F8237_RS00125	COG1104	cysteine desulfurase activity
F8237_RS00130	COG2945	thiolester hydrolase activity
F8237_RS00140	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
F8237_RS00145	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F8237_RS00150	COG2271	Major facilitator Superfamily
F8237_RS00155	COG2259	Doxx family
F8237_RS00175	COG0739	heme binding
F8237_RS00180	COG0753	catalase activity
F8237_RS00195	COG0438	transferase activity, transferring glycosyl groups
F8237_RS00220	COG0697	spore germination
F8237_RS00230	COG2084	Dehydrogenase
F8237_RS00240	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
F8237_RS00245	COG0860	N-Acetylmuramoyl-L-alanine amidase
F8237_RS00250	COG1530	ribonuclease E activity
F8237_RS00250	COG1530	ribonuclease E activity
F8237_RS00270	COG1301	dicarboxylic acid transport
F8237_RS00275	COG1268	BioY protein
F8237_RS00280	COG0436	Aminotransferase
F8237_RS00300	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F8237_RS00305	COG0511	ligase activity, forming carbon-carbon bonds
F8237_RS00310	COG0439	Biotin carboxylase
F8237_RS00320	COG0784	Response regulator, receiver
F8237_RS00325	COG3920	Histidine kinase
F8237_RS00330	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
F8237_RS00340	COG0657	acetylesterase activity
F8237_RS00390	COG4191	Histidine kinase
F8237_RS00390	COG0784	Response regulator, receiver
F8237_RS00400	COG0697	spore germination
F8237_RS00405	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F8237_RS00415	COG0515	serine threonine protein kinase
F8237_RS00415	COG2815	serine threonine protein kinase
F8237_RS00470	COG2824	Alkylphosphonate utilization operon protein PhnA
F8237_RS00500	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
F8237_RS00525	COG1309	transcriptional regulator
F8237_RS00560	COG1376	ErfK ybiS ycfS ynhG family protein
F8237_RS00590	COG0784	Response regulator, receiver
F8237_RS00590	COG4191	Histidine kinase
F8237_RS00600	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
F8237_RS00605	COG2894	cell division
F8237_RS00610	COG0850	regulation of cytokinetic process
F8237_RS00620	COG1309	transcriptional regulator
F8237_RS00625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F8237_RS00655	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
F8237_RS00715	COG0657	acetylesterase activity
F8237_RS00730	COG0488	(ABC) transporter
F8237_RS00745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F8237_RS00750	COG1902	pentaerythritol trinitrate reductase activity
F8237_RS00790	COG0174	glutamine synthetase
F8237_RS00810	COG2365	Tyrosine phosphatase family
F8237_RS00820	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS00855	COG3483	tryptophan 2,3-dioxygenase activity
F8237_RS00865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F8237_RS00900	COG3045	CreA protein
F8237_RS00910	COG0386	Belongs to the glutathione peroxidase family
F8237_RS00945	COG0281	malic enzyme
F8237_RS00945	COG0280	phosphate acetyltransferase
F8237_RS00955	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F8237_RS00960	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
F8237_RS00975	COG1175	transmembrane transport
F8237_RS00990	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
F8237_RS00995	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F8237_RS01005	COG2153	protein acetylation
F8237_RS01030	COG1278	Cold shock
F8237_RS01035	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F8237_RS01040	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F8237_RS01060	COG0248	Ppx GppA phosphatase
F8237_RS01065	COG0861	Integral membrane protein TerC family
F8237_RS01070	COG0105	UTP biosynthetic process
F8237_RS01080	COG0488	(ABC) transporter
F8237_RS01100	COG0795	lipopolysaccharide-transporting ATPase activity
F8237_RS01110	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
F8237_RS01120	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
F8237_RS01125	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F8237_RS01165	COG0194	GDP metabolic process
F8237_RS01170	COG1561	YicC-like family, N-terminal region
F8237_RS01175	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F8237_RS01180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F8237_RS01195	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F8237_RS01210	COG0360	Binds together with S18 to 16S ribosomal RNA
F8237_RS01215	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F8237_RS01225	COG0359	binds to the 23S rRNA
F8237_RS01255	COG0305	Participates in initiation and elongation during chromosome replication
F8237_RS01260	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F8237_RS01290	COG2186	Transcriptional regulator
F8237_RS01295	COG2084	Dehydrogenase
F8237_RS01300	COG0765	amino acid transport
F8237_RS01305	COG0765	amino acid transport
F8237_RS01310	COG1126	abc transporter atp-binding protein
F8237_RS01320	COG0698	ribose 5-phosphate isomerase
F8237_RS01345	COG1286	toxin biosynthetic process
F8237_RS01350	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
F8237_RS01355	COG0300	oxidoreductase activity
F8237_RS01370	COG1160	GTP binding
F8237_RS01410	COG0306	phosphate transporter
F8237_RS01415	COG1392	Phosphate transport regulator
F8237_RS01450	COG1393	Belongs to the ArsC family
F8237_RS01455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F8237_RS01455	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F8237_RS01460	COG0625	glutathione transferase activity
F8237_RS01490	COG0583	DNA-binding transcription factor activity
F8237_RS01545	COG0242	peptide deformylase activity
F8237_RS01610	COG1278	Cold shock
F8237_RS01615	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F8237_RS01615	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F8237_RS01640	COG2130	NADP-dependent
F8237_RS01660	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
F8237_RS01865	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F8237_RS01880	COG3750	Belongs to the UPF0335 family
F8237_RS02035	COG1671	Belongs to the UPF0178 family
F8237_RS02040	COG0488	(ABC) transporter
F8237_RS02050	COG0493	'glutamate synthase
F8237_RS02050	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
F8237_RS02055	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS02080	COG1960	acyl-CoA dehydrogenase activity
F8237_RS02105	COG1024	Enoyl-CoA hydratase
F8237_RS02110	COG0183	Belongs to the thiolase family
F8237_RS02115	COG2271	Major facilitator Superfamily
F8237_RS02125	COG4964	Belongs to the GSP D family
F8237_RS02130	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F8237_RS02155	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
F8237_RS02155	COG2066	Belongs to the glutaminase family
F8237_RS02175	COG2186	Transcriptional regulator
F8237_RS02190	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F8237_RS02205	COG0800	Aldolase
F8237_RS02210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F8237_RS02215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F8237_RS02220	COG0395	ABC-type sugar transport system, permease component
F8237_RS02225	COG1175	transmembrane transport
F8237_RS02235	COG3842	ATPase activity
F8237_RS02240	COG1609	Transcriptional regulator
F8237_RS02245	COG0129	dihydroxy-acid dehydratase activity
F8237_RS02250	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS02255	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS02270	COG1994	Peptidase M50
F8237_RS02285	COG0848	biopolymer transport protein
F8237_RS02295	COG3128	pkhd-type hydroxylase
F8237_RS02300	COG4774	siderophore transport
F8237_RS02315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F8237_RS02340	COG1137	ATPase activity
F8237_RS02380	COG1595	DNA-templated transcription, initiation
F8237_RS02395	COG3220	belongs to the UPF0276 family
F8237_RS02420	COG4232	protein-disulfide reductase activity
F8237_RS02455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F8237_RS02485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F8237_RS02510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F8237_RS02515	COG3189	MarR family transcriptional regulator
F8237_RS02525	COG2009	succinate dehydrogenase
F8237_RS02570	COG1959	2 iron, 2 sulfur cluster binding
F8237_RS02600	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
F8237_RS02605	COG4591	ABC-type transport system involved in lipoprotein release permease component
F8237_RS02605	COG1136	(ABC) transporter
F8237_RS02620	COG1309	transcriptional regulator
F8237_RS02660	COG1388	LysM domain
F8237_RS02660	COG1376	ErfK ybiS ycfS ynhG family protein
F8237_RS02665	COG2863	cytochrome
F8237_RS02680	COG0640	Transcriptional regulator
F8237_RS02685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F8237_RS02690	COG0730	response to heat
F8237_RS02700	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
F8237_RS02770	COG0402	S-adenosylhomocysteine deaminase activity
F8237_RS02780	COG1309	transcriptional regulator
F8237_RS02785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F8237_RS02875	COG2072	flavoprotein involved in K transport
F8237_RS02880	COG0318	PFAM AMP-dependent synthetase and ligase
F8237_RS02910	COG1566	PFAM secretion protein HlyD family protein
F8237_RS02920	COG1289	transmembrane transporter activity
F8237_RS03000	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F8237_RS03005	COG1301	dicarboxylic acid transport
F8237_RS03075	COG1846	Transcriptional regulator
F8237_RS03115	COG2080	2 iron, 2 sulfur cluster binding
F8237_RS03120	COG2010	Cytochrome c
F8237_RS03120	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F8237_RS03160	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F8237_RS03185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F8237_RS03190	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F8237_RS03200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F8237_RS03210	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F8237_RS03215	COG0436	Aminotransferase
F8237_RS03255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F8237_RS03260	COG3251	PFAM MbtH domain protein
F8237_RS03265	COG3158	transport of potassium into the cell
F8237_RS03270	COG3158	transport of potassium into the cell
F8237_RS03280	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
F8237_RS03290	COG1183	phosphatidylcholine synthase activity
F8237_RS03295	COG0688	phosphatidylethanolamine metabolic process
F8237_RS03300	COG5265	(ABC) transporter
F8237_RS03310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F8237_RS03320	COG0215	cysteine-tRNA ligase activity
F8237_RS03340	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
F8237_RS03345	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
F8237_RS03355	COG0642	Histidine kinase
F8237_RS03385	COG1012	belongs to the aldehyde dehydrogenase family
F8237_RS03395	COG3585	molybdate ion transport
F8237_RS03395	COG2005	Transcriptional regulator
F8237_RS03405	COG0583	DNA-binding transcription factor activity
F8237_RS03435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F8237_RS03435	COG1017	nitric oxide dioxygenase activity
F8237_RS03445	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F8237_RS03450	COG0121	glutamine amidotransferase
F8237_RS03455	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F8237_RS03505	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
F8237_RS03510	COG0546	phosphoglycolate phosphatase activity
F8237_RS03520	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F8237_RS03525	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
F8237_RS03540	COG0745	RESPONSE REGULATOR receiver
F8237_RS03545	COG1309	transcriptional regulator
F8237_RS03560	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
F8237_RS03565	COG0489	protein tyrosine kinase activity
F8237_RS03575	COG2084	Dehydrogenase
F8237_RS03585	COG2202	Pas domain
F8237_RS03585	COG2205	protein histidine kinase activity
F8237_RS03610	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F8237_RS03635	COG0445	tRNA wobble uridine modification
F8237_RS03675	COG0402	S-adenosylhomocysteine deaminase activity
F8237_RS03685	COG3485	protocatechuate 3,4-dioxygenase
F8237_RS03690	COG0277	FAD linked oxidase domain protein
F8237_RS03695	COG1129	ABC transporter
F8237_RS03700	COG1172	Belongs to the binding-protein-dependent transport system permease family
F8237_RS03705	COG1172	Belongs to the binding-protein-dependent transport system permease family
F8237_RS03710	COG1879	ABC-type sugar transport system periplasmic component
F8237_RS03720	COG0318	PFAM AMP-dependent synthetase and ligase
F8237_RS03740	COG2351	hydroxyisourate hydrolase activity
F8237_RS03770	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
F8237_RS03785	COG1648	precorrin-2 dehydrogenase activity
F8237_RS03785	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F8237_RS03790	COG1797	cobyrinic acid a,c-diamide synthase activity
F8237_RS03795	COG2875	Belongs to the precorrin methyltransferase family
F8237_RS03810	COG2099	Precorrin-6x reductase
F8237_RS03855	COG1492	cobalamin metabolic process
F8237_RS03865	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
F8237_RS03875	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
F8237_RS03880	COG0778	Nitroreductase
F8237_RS03910	COG0583	DNA-binding transcription factor activity
F8237_RS03915	COG0346	lactoylglutathione lyase activity
F8237_RS03920	COG0400	carboxylic ester hydrolase activity
F8237_RS03930	COG0154	amidase activity
F8237_RS03940	COG4608	Belongs to the ABC transporter superfamily
F8237_RS03945	COG0444	Belongs to the ABC transporter superfamily
F8237_RS03950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F8237_RS03975	COG0714	Associated with various cellular activities
F8237_RS03980	COG3256	nitric oxide reductase
F8237_RS03995	COG1845	cytochrome c oxidase, subunit III
F8237_RS04000	COG4214	carbohydrate transport
F8237_RS04010	COG4213	ABC transporter substrate-binding protein
F8237_RS04015	COG3386	PFAM SMP-30 Gluconolaconase
F8237_RS04050	COG1053	succinate dehydrogenase
F8237_RS04070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F8237_RS04075	COG4521	taurine ABC transporter
F8237_RS04080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F8237_RS04085	COG1116	anion transmembrane transporter activity
F8237_RS04090	COG2855	membrane
F8237_RS04100	COG0410	ABC transporter
F8237_RS04130	COG1309	transcriptional regulator
F8237_RS04135	COG2072	flavoprotein involved in K transport
F8237_RS04145	COG1982	Orn Lys Arg decarboxylase major
F8237_RS04160	COG2423	ornithine cyclodeaminase activity
F8237_RS04170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F8237_RS04195	COG2084	Dehydrogenase
F8237_RS04200	COG3622	Belongs to the hyi family
F8237_RS04205	COG3960	tartronate-semialdehyde synthase activity
F8237_RS04210	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
F8237_RS04245	COG1802	Transcriptional regulator
F8237_RS04255	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F8237_RS04275	COG1278	Cold shock
F8237_RS04290	COG0443	Heat shock 70 kDa protein
F8237_RS04315	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F8237_RS04320	COG0179	Fumarylacetoacetate (FAA) hydrolase
F8237_RS04360	COG0604	alcohol dehydrogenase
F8237_RS04360	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS04360	COG3321	synthase
F8237_RS04365	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F8237_RS04370	COG2205	protein histidine kinase activity
F8237_RS04370	COG2202	Pas domain
F8237_RS04390	COG3383	formate dehydrogenase (NAD+) activity
F8237_RS04395	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F8237_RS04405	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F8237_RS04410	COG2205	protein histidine kinase activity
F8237_RS04415	COG0745	RESPONSE REGULATOR receiver
F8237_RS04430	COG3088	subunit of a heme lyase
F8237_RS04435	COG1138	Cytochrome C-type biogenesis protein
F8237_RS04440	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
F8237_RS04445	COG4235	cytochrome complex assembly
F8237_RS04470	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
F8237_RS04490	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
F8237_RS04500	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
F8237_RS04520	COG0477	Major facilitator Superfamily
F8237_RS04525	COG2983	Belongs to the UPF0260 family
F8237_RS04530	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
F8237_RS04600	COG0798	PFAM Bile acid sodium symporter
F8237_RS04625	COG1802	Transcriptional regulator
F8237_RS04630	COG0179	Fumarylacetoacetate (FAA) hydrolase
F8237_RS04665	COG2205	protein histidine kinase activity
F8237_RS04675	COG2166	iron-sulfur cluster assembly
F8237_RS04680	COG4957	zinc ion binding
F8237_RS04725	COG0433	COG0433 Predicted ATPase
F8237_RS04740	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F8237_RS04750	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F8237_RS04800	COG1703	isobutyryl-CoA mutase activity
F8237_RS04815	COG2827	Endonuclease containing a URI domain
F8237_RS04865	COG1024	Enoyl-CoA hydratase
F8237_RS04895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F8237_RS04905	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS04910	COG0587	DNA-directed DNA polymerase activity
F8237_RS04930	COG1573	uracil-dna glycosylase
F8237_RS04940	COG1473	amidohydrolase
F8237_RS04995	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F8237_RS05005	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
F8237_RS05020	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F8237_RS05025	COG1657	PFAM Prenyltransferase squalene oxidase
F8237_RS05030	COG1233	COG1233 Phytoene dehydrogenase and related
F8237_RS05035	COG1562	ergosterol biosynthetic process
F8237_RS05040	COG1562	ergosterol biosynthetic process
F8237_RS05060	COG4302	ethanolamine ammonia-lyase activity
F8237_RS05070	COG4303	Ethanolamine ammonia lyase large subunit
F8237_RS05085	COG2267	carboxylic ester hydrolase activity
F8237_RS05115	COG3300	MHYT domain
F8237_RS05115	COG5001	Diguanylate cyclase
F8237_RS05120	COG1595	DNA-templated transcription, initiation
F8237_RS05125	COG3806	Anti-sigma factor
F8237_RS05130	COG1595	DNA-templated transcription, initiation
F8237_RS05135	COG3046	protein related to deoxyribodipyrimidine photolyase
F8237_RS05140	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
F8237_RS05155	COG3842	ATPase activity
F8237_RS05160	COG1175	transmembrane transport
F8237_RS05165	COG0395	ABC-type sugar transport system, permease component
F8237_RS05170	COG1653	transport
F8237_RS05205	COG2721	sulfolactate sulfo-lyase activity
F8237_RS05225	COG0559	Belongs to the binding-protein-dependent transport system permease family
F8237_RS05235	COG1846	Transcriptional regulator
F8237_RS05240	COG3971	2-oxopent-4-enoate hydratase activity
F8237_RS05250	COG1012	belongs to the aldehyde dehydrogenase family
F8237_RS05260	COG0179	Fumarylacetoacetate (FAA) hydrolase
F8237_RS05265	COG0028	Belongs to the TPP enzyme family
F8237_RS05275	COG3145	DNA-N1-methyladenine dioxygenase activity
F8237_RS05305	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS05310	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
F8237_RS05325	COG1024	Enoyl-CoA hydratase
F8237_RS05335	COG1024	Enoyl-CoA hydratase
F8237_RS05340	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS05350	COG1960	acyl-CoA dehydrogenase activity
F8237_RS05355	COG1024	Enoyl-CoA hydratase
F8237_RS05370	COG1024	Enoyl-CoA hydratase
F8237_RS05375	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS05390	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F8237_RS05395	COG0625	glutathione transferase activity
F8237_RS05400	COG2070	2-Nitropropane dioxygenase
F8237_RS05410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F8237_RS05420	COG0840	transmembrane signaling receptor activity
F8237_RS05425	COG0840	transmembrane signaling receptor activity
F8237_RS05430	COG0840	transmembrane signaling receptor activity
F8237_RS05435	COG3395	kinase activity
F8237_RS05440	COG3622	Belongs to the hyi family
F8237_RS05445	COG2084	Dehydrogenase
F8237_RS05450	COG0235	Class ii aldolase
F8237_RS05475	COG0559	Belongs to the binding-protein-dependent transport system permease family
F8237_RS05485	COG4336	lyase activity
F8237_RS05490	COG0583	DNA-binding transcription factor activity
F8237_RS05500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F8237_RS05505	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
F8237_RS05510	COG0473	3-isopropylmalate dehydrogenase activity
F8237_RS05515	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS05525	COG0765	amino acid transport
F8237_RS05530	COG4597	amino acid ABC transporter
F8237_RS05540	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F8237_RS05545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8237_RS05570	COG0477	Major facilitator Superfamily
F8237_RS05575	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F8237_RS05610	COG2050	protein possibly involved in aromatic compounds catabolism
F8237_RS05615	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F8237_RS05620	COG2151	metal-sulfur cluster biosynthetic enzyme
F8237_RS05625	COG3396	Phenylacetate-CoA oxygenase
F8237_RS05630	COG3460	Phenylacetate-CoA oxygenase
F8237_RS05635	COG3396	Phenylacetate-CoA oxygenase
F8237_RS05640	COG3327	negative regulation of DNA-templated transcription, initiation
F8237_RS05645	COG0596	Alpha beta hydrolase
F8237_RS05650	COG2733	membrane
F8237_RS05685	COG2124	cytochrome p450
F8237_RS05685	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F8237_RS05690	COG2267	carboxylic ester hydrolase activity
F8237_RS05710	COG4166	transmembrane transport
F8237_RS05715	COG0601	transmembrane transport
F8237_RS05720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F8237_RS05725	COG0444	Belongs to the ABC transporter superfamily
F8237_RS05730	COG4608	Belongs to the ABC transporter superfamily
F8237_RS05735	COG0405	Gamma-glutamyltransferase
F8237_RS05750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F8237_RS05765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F8237_RS05775	COG0028	Belongs to the TPP enzyme family
F8237_RS05775	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
F8237_RS05785	COG2124	cytochrome p450
F8237_RS05790	COG0205	6-phosphofructokinase activity
F8237_RS05805	COG0673	inositol 2-dehydrogenase activity
F8237_RS05825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F8237_RS05830	COG1309	transcriptional regulator
F8237_RS05840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F8237_RS05845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F8237_RS05880	COG0129	dihydroxy-acid dehydratase activity
F8237_RS05895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F8237_RS05900	COG3386	PFAM SMP-30 Gluconolaconase
F8237_RS05915	COG1522	sequence-specific DNA binding
F8237_RS05925	COG1063	alcohol dehydrogenase
F8237_RS05930	COG0697	spore germination
F8237_RS05935	COG0656	L-ascorbic acid biosynthetic process
F8237_RS05945	COG0243	molybdopterin cofactor binding
F8237_RS05950	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F8237_RS05955	COG1017	nitric oxide dioxygenase activity
F8237_RS05955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F8237_RS05960	COG2223	nitrite transmembrane transporter activity
F8237_RS05965	COG1116	anion transmembrane transporter activity
F8237_RS05970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F8237_RS05975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F8237_RS05990	COG2815	serine threonine protein kinase
F8237_RS05990	COG0515	serine threonine protein kinase
F8237_RS06000	COG0702	epimerase
F8237_RS06010	COG3485	protocatechuate 3,4-dioxygenase
F8237_RS06030	COG2202	Pas domain
F8237_RS06030	COG3920	Histidine kinase
F8237_RS06035	COG0785	Cytochrome C biogenesis protein
F8237_RS06055	COG1396	sequence-specific DNA binding
F8237_RS06060	COG2989	Protein conserved in bacteria
F8237_RS06065	COG1024	Enoyl-CoA hydratase
F8237_RS06070	COG0473	3-isopropylmalate dehydrogenase activity
F8237_RS06085	COG0297	glycogen (starch) synthase activity
F8237_RS06110	COG2217	Heavy metal translocating P-type atpase
F8237_RS06125	COG2010	Cytochrome c
F8237_RS06140	COG3278	Belongs to the heme-copper respiratory oxidase family
F8237_RS06145	COG0516	GMP reductase activity
F8237_RS06145	COG0517	IMP dehydrogenase activity
F8237_RS06155	COG4191	Histidine kinase
F8237_RS06160	COG4566	intracellular signal transduction
F8237_RS06165	COG0745	RESPONSE REGULATOR receiver
F8237_RS06170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F8237_RS06190	COG1132	(ABC) transporter
F8237_RS06195	COG0438	transferase activity, transferring glycosyl groups
F8237_RS06205	COG2015	COG2015, Alkyl sulfatase and related hydrolases
F8237_RS06210	COG3706	GGDEF domain
F8237_RS06225	COG4106	trans-aconitate 2-methyltransferase activity
F8237_RS06235	COG0154	amidase activity
F8237_RS06245	COG0473	3-isopropylmalate dehydrogenase activity
F8237_RS06250	COG2814	Major facilitator Superfamily
F8237_RS06255	COG1032	radical SAM domain protein
F8237_RS06270	COG0446	pyridine nucleotide-disulphide oxidoreductase
F8237_RS06290	COG3258	Cytochrome c
F8237_RS06295	COG1653	transport
F8237_RS06300	COG1175	transmembrane transport
F8237_RS06305	COG3833	ABC-type maltose transport systems, permease component
F8237_RS06310	COG0471	metal ion transport
F8237_RS06320	COG1335	isochorismatase
F8237_RS06335	COG1053	succinate dehydrogenase
F8237_RS06340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F8237_RS06360	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS06395	COG0741	lytic transglycosylase activity
F8237_RS06405	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS06410	COG0028	Belongs to the TPP enzyme family
F8237_RS06415	COG1414	Transcriptional regulator
F8237_RS06430	COG1129	ABC transporter
F8237_RS06465	COG4948	Mandelate Racemase Muconate Lactonizing
F8237_RS06470	COG1473	amidohydrolase
F8237_RS06480	COG3685	Protein conserved in bacteria
F8237_RS06485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F8237_RS06540	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F8237_RS06550	COG1960	acyl-CoA dehydrogenase activity
F8237_RS06565	COG0737	Belongs to the 5'-nucleotidase family
F8237_RS06565	COG1525	nuclease
F8237_RS06565	COG4085	toxin activity
F8237_RS06570	COG0123	including yeast histone deacetylase and acetoin utilization protein
F8237_RS06575	COG1722	exodeoxyribonuclease VII activity
F8237_RS06580	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F8237_RS06590	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
F8237_RS06595	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F8237_RS06625	COG0477	Major facilitator Superfamily
F8237_RS06630	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F8237_RS06635	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
F8237_RS06645	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F8237_RS06655	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F8237_RS06680	COG0259	pyridoxamine-phosphate oxidase activity
F8237_RS06685	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS06695	COG0598	Magnesium transport protein CorA
F8237_RS06710	COG0318	PFAM AMP-dependent synthetase and ligase
F8237_RS06735	COG1960	acyl-CoA dehydrogenase activity
F8237_RS06745	COG0475	glutathione-regulated potassium exporter activity
F8237_RS06745	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F8237_RS06755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F8237_RS06775	COG0656	L-ascorbic acid biosynthetic process
F8237_RS06885	COG3300	MHYT domain
F8237_RS06885	COG5001	Diguanylate cyclase
F8237_RS06900	COG4451	ribulose bisphosphate carboxylase, small
F8237_RS06905	COG1850	ribulose-bisphosphate carboxylase activity
F8237_RS06925	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
F8237_RS06960	COG2814	Major facilitator Superfamily
F8237_RS06965	COG1309	transcriptional regulator
F8237_RS07010	COG0009	L-threonylcarbamoyladenylate synthase
F8237_RS07015	COG0277	FAD linked oxidase domain protein
F8237_RS07030	COG0494	nUDIX hydrolase
F8237_RS07050	COG2135	peptidase activity
F8237_RS07085	COG1595	DNA-templated transcription, initiation
F8237_RS07095	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F8237_RS07100	COG0354	folic acid binding
F8237_RS07105	COG0519	Catalyzes the synthesis of GMP from XMP
F8237_RS07110	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
F8237_RS07135	COG0840	transmembrane signaling receptor activity
F8237_RS07150	COG0604	alcohol dehydrogenase
F8237_RS07160	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F8237_RS07165	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F8237_RS07180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F8237_RS07180	COG0574	Belongs to the PEP-utilizing enzyme family
F8237_RS07195	COG0751	glycine-tRNA ligase activity
F8237_RS07200	COG0752	glycyl-tRNA synthetase alpha subunit
F8237_RS07225	COG0142	geranyltranstransferase activity
F8237_RS07235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F8237_RS07240	COG1280	lysine exporter protein (LysE YggA)
F8237_RS07250	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F8237_RS07265	COG1573	uracil-dna glycosylase
F8237_RS07275	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F8237_RS07290	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
F8237_RS07305	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F8237_RS07305	COG0574	Belongs to the PEP-utilizing enzyme family
F8237_RS07320	COG0456	acetyltransferase
F8237_RS07320	COG1846	Transcriptional regulator
F8237_RS07325	COG0521	Mo-molybdopterin cofactor biosynthetic process
F8237_RS07330	COG2321	neutral zinc metallopeptidase
F8237_RS07335	COG2189	Belongs to the N(4) N(6)-methyltransferase family
F8237_RS07340	COG0625	glutathione transferase activity
F8237_RS07345	COG0840	transmembrane signaling receptor activity
F8237_RS07345	COG2972	Histidine kinase
F8237_RS07350	COG4251	negative regulation of phosphorylation
F8237_RS07375	COG0625	glutathione transferase activity
F8237_RS07390	COG1194	a g-specific adenine glycosylase
F8237_RS07405	COG1196	nuclear chromosome segregation
F8237_RS07415	COG1704	LemA family
F8237_RS07440	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F8237_RS07455	COG2857	Cytochrome c1
F8237_RS07455	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F8237_RS07460	COG0723	plastoquinol--plastocyanin reductase activity
F8237_RS07465	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F8237_RS07470	COG0602	queuosine metabolic process
F8237_RS07480	COG0408	coproporphyrinogen oxidase activity
F8237_RS07500	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
F8237_RS07505	COG2943	transferase activity, transferring hexosyl groups
F8237_RS07540	COG2863	cytochrome
F8237_RS07565	COG0617	tRNA 3'-terminal CCA addition
F8237_RS07575	COG0494	nUDIX hydrolase
F8237_RS07585	COG0714	Associated with various cellular activities
F8237_RS07610	COG4771	TonB-dependent receptor
F8237_RS07630	COG0463	Glycosyl transferase, family 2
F8237_RS07640	COG0494	nUDIX hydrolase
F8237_RS07695	COG0501	Belongs to the peptidase M48B family
F8237_RS07710	COG1902	pentaerythritol trinitrate reductase activity
F8237_RS07725	COG0395	ABC-type sugar transport system, permease component
F8237_RS07740	COG3842	ATPase activity
F8237_RS07760	COG1349	DNA-binding transcription factor activity
F8237_RS07785	COG1607	acyl-coa hydrolase
F8237_RS07795	COG0183	Belongs to the thiolase family
F8237_RS07810	COG1309	transcriptional regulator
F8237_RS07835	COG3214	Protein conserved in bacteria
F8237_RS07880	COG3237	CsbD-like
F8237_RS07890	COG0405	Gamma-glutamyltransferase
F8237_RS07895	COG1054	Belongs to the UPF0176 family
F8237_RS07900	COG2900	Belongs to the SlyX family
F8237_RS07905	COG5001	Diguanylate cyclase
F8237_RS07905	COG4251	negative regulation of phosphorylation
F8237_RS07905	COG2203	Gaf domain
F8237_RS07905	COG3706	GGDEF domain
F8237_RS07915	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F8237_RS07920	COG4566	intracellular signal transduction
F8237_RS07925	COG0181	hydroxymethylbilane synthase activity
F8237_RS07950	COG5001	Diguanylate cyclase
F8237_RS07950	COG3300	MHYT domain
F8237_RS08000	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F8237_RS08045	COG0438	transferase activity, transferring glycosyl groups
F8237_RS08065	COG1045	serine acetyltransferase
F8237_RS08070	COG2244	polysaccharide biosynthetic process
F8237_RS08075	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F8237_RS08085	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F8237_RS08085	COG2755	lipolytic protein G-D-S-L family
F8237_RS08110	COG3206	protein involved in exopolysaccharide biosynthesis
F8237_RS08110	COG0489	protein tyrosine kinase activity
F8237_RS08120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F8237_RS08130	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F8237_RS08180	COG2201	protein-glutamate methylesterase activity
F8237_RS08190	COG0840	transmembrane signaling receptor activity
F8237_RS08195	COG0835	chemotaxis
F8237_RS08200	COG0840	transmembrane signaling receptor activity
F8237_RS08205	COG0835	chemotaxis
F8237_RS08210	COG2198	Histidine kinase
F8237_RS08210	COG0643	Histidine kinase
F8237_RS08215	COG0745	RESPONSE REGULATOR receiver
F8237_RS08250	COG3485	protocatechuate 3,4-dioxygenase
F8237_RS08255	COG3485	protocatechuate 3,4-dioxygenase
F8237_RS08260	COG0583	DNA-binding transcription factor activity
F8237_RS08270	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
F8237_RS08290	COG0431	NADPH-dependent FMN reductase
F8237_RS08290	COG1053	succinate dehydrogenase
F8237_RS08290	COG3976	FMN-binding domain protein
F8237_RS08300	COG1414	Transcriptional regulator
F8237_RS08305	COG2084	Dehydrogenase
F8237_RS08330	COG3383	formate dehydrogenase (NAD+) activity
F8237_RS08335	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
F8237_RS08360	COG1763	Mo-molybdopterin cofactor biosynthetic process
F8237_RS08370	COG0746	molybdenum cofactor guanylyltransferase activity
F8237_RS08375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F8237_RS08380	COG0303	'Molybdopterin
F8237_RS08485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F8237_RS08510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F8237_RS08515	COG0683	leucine binding
F8237_RS08525	COG0411	ABC transporter
F8237_RS08545	COG3239	Fatty acid desaturase
F8237_RS08575	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F8237_RS08595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8237_RS08620	COG1024	Enoyl-CoA hydratase
F8237_RS08625	COG0405	Gamma-glutamyltransferase
F8237_RS08635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F8237_RS08640	COG1126	abc transporter atp-binding protein
F8237_RS08645	COG0765	amino acid transport
F8237_RS08650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8237_RS08660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F8237_RS08665	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F8237_RS08675	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F8237_RS08680	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
F8237_RS08685	COG2080	2 iron, 2 sulfur cluster binding
F8237_RS08690	COG1309	transcriptional regulator
F8237_RS08735	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F8237_RS08765	COG1595	DNA-templated transcription, initiation
F8237_RS08785	COG3766	membrane
F8237_RS08810	COG0754	glutathionylspermidine amidase activity
F8237_RS08820	COG2201	protein-glutamate methylesterase activity
F8237_RS08825	COG0784	Response regulator, receiver
F8237_RS08825	COG2198	Histidine kinase
F8237_RS08825	COG0643	Histidine kinase
F8237_RS08830	COG0835	chemotaxis
F8237_RS08835	COG0784	Response regulator, receiver
F8237_RS08835	COG2198	Histidine kinase
F8237_RS08835	COG0643	Histidine kinase
F8237_RS08875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F8237_RS08930	COG1376	ErfK ybiS ycfS ynhG family protein
F8237_RS08940	COG0028	Belongs to the TPP enzyme family
F8237_RS08945	COG1376	ErfK ybiS ycfS ynhG family protein
F8237_RS08960	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F8237_RS08980	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
F8237_RS08985	COG0501	Belongs to the peptidase M48B family
F8237_RS09005	COG0583	DNA-binding transcription factor activity
F8237_RS09010	COG1960	acyl-CoA dehydrogenase activity
F8237_RS09020	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
F8237_RS09045	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS09050	COG1272	protein, Hemolysin III
F8237_RS09055	COG3106	COG3106 Predicted ATPase
F8237_RS09060	COG3768	UPF0283 membrane protein
F8237_RS09085	COG1278	Cold shock
F8237_RS09095	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
F8237_RS09095	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
F8237_RS09095	COG0506	proline dehydrogenase activity
F8237_RS09110	COG0625	glutathione transferase activity
F8237_RS09130	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
F8237_RS09135	COG1704	LemA family
F8237_RS09140	COG1024	Enoyl-CoA hydratase
F8237_RS09145	COG1960	acyl-CoA dehydrogenase activity
F8237_RS09150	COG1960	acyl-CoA dehydrogenase activity
F8237_RS09165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F8237_RS09175	COG2514	catechol 2,3-dioxygenase activity
F8237_RS09180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F8237_RS09230	COG0028	Belongs to the TPP enzyme family
F8237_RS09235	COG0800	Aldolase
F8237_RS09240	COG3734	2-keto-3-deoxy-galactonokinase
F8237_RS09250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F8237_RS09255	COG3284	Transcriptional regulator
F8237_RS09260	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
F8237_RS09280	COG0840	transmembrane signaling receptor activity
F8237_RS09295	COG1309	transcriptional regulator
F8237_RS09310	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F8237_RS09355	COG0564	pseudouridine synthase activity
F8237_RS09360	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F8237_RS09380	COG3706	GGDEF domain
F8237_RS09385	COG1280	lysine exporter protein (LysE YggA)
F8237_RS09390	COG0745	RESPONSE REGULATOR receiver
F8237_RS09415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F8237_RS09420	COG0358	DNA primase activity
F8237_RS09455	COG1280	lysine exporter protein (LysE YggA)
F8237_RS09460	COG0640	Transcriptional regulator
F8237_RS09485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F8237_RS09490	COG0596	Alpha beta hydrolase
F8237_RS09505	COG0505	Belongs to the CarA family
F8237_RS09535	COG2814	Major facilitator Superfamily
F8237_RS09540	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F8237_RS09545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F8237_RS09550	COG1522	sequence-specific DNA binding
F8237_RS09560	COG0583	DNA-binding transcription factor activity
F8237_RS09565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F8237_RS09600	COG2801	Transposase and inactivated derivatives
F8237_RS09605	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
F8237_RS09630	COG2205	protein histidine kinase activity
F8237_RS09635	COG0183	Belongs to the thiolase family
F8237_RS09640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F8237_RS09665	COG0625	glutathione transferase activity
F8237_RS09680	COG2223	nitrite transmembrane transporter activity
F8237_RS09690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F8237_RS09705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F8237_RS09710	COG0659	secondary active sulfate transmembrane transporter activity
F8237_RS09720	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F8237_RS09730	COG0436	Aminotransferase
F8237_RS09740	COG0625	glutathione transferase activity
F8237_RS09760	COG0667	Aldo Keto reductase
F8237_RS09790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F8237_RS09795	COG1999	signal sequence binding
F8237_RS09810	COG0583	DNA-binding transcription factor activity
F8237_RS09825	COG0556	nucleotide-excision repair
F8237_RS09870	COG2030	dehydratase
F8237_RS09880	COG0012	GTP binding
F8237_RS09885	COG0193	aminoacyl-tRNA hydrolase activity
F8237_RS09890	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F8237_RS09905	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F8237_RS09915	COG1496	oxidoreductase activity
F8237_RS09925	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F8237_RS09935	COG1181	Belongs to the D-alanine--D-alanine ligase family
F8237_RS09945	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
F8237_RS09945	COG3608	succinylglutamate desuccinylase aspartoacylase
F8237_RS09955	COG0542	response to heat
F8237_RS09985	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F8237_RS09995	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F8237_RS10005	COG1942	4-Oxalocrotonate Tautomerase
F8237_RS10010	COG0124	histidyl-tRNA synthetase
F8237_RS10025	COG1846	Transcriptional regulator
F8237_RS10030	COG0745	RESPONSE REGULATOR receiver
F8237_RS10060	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
F8237_RS10065	COG1278	Cold shock
F8237_RS10070	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
F8237_RS10075	COG0322	excinuclease ABC activity
F8237_RS10080	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F8237_RS10090	COG0314	molybdopterin synthase activity
F8237_RS10095	COG2890	protein-(glutamine-N5) methyltransferase activity
F8237_RS10105	COG1295	ribonuclease BN
F8237_RS10115	COG5001	Diguanylate cyclase
F8237_RS10125	COG0745	RESPONSE REGULATOR receiver
F8237_RS10130	COG0196	riboflavin kinase activity
F8237_RS10135	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F8237_RS10140	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F8237_RS10150	COG0612	Peptidase, M16
F8237_RS10155	COG0612	Peptidase, M16
F8237_RS10190	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F8237_RS10195	COG0742	ribosomal rna small subunit methyltransferase
F8237_RS10200	COG1187	pseudouridine synthase activity
F8237_RS10205	COG0590	tRNA wobble adenosine to inosine editing
F8237_RS10210	COG0596	Alpha beta hydrolase
F8237_RS10215	COG0151	Belongs to the GarS family
F8237_RS10245	COG1570	exodeoxyribonuclease VII activity
F8237_RS10265	COG1663	tetraacyldisaccharide 4'-kinase activity
F8237_RS10270	COG1519	Transferase
F8237_RS10290	COG0312	modulator of DNA gyrase
F8237_RS10330	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
F8237_RS10335	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F8237_RS10340	COG0463	Glycosyl transferase, family 2
F8237_RS10350	COG3416	Protein conserved in bacteria
F8237_RS10360	COG1376	ErfK ybiS ycfS ynhG family protein
F8237_RS10360	COG1388	LysM domain
F8237_RS10375	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F8237_RS10380	COG0459	protein refolding
F8237_RS10395	COG1620	l-lactate permease
F8237_RS10400	COG4178	(ABC) transporter
F8237_RS10415	COG0247	lactate metabolic process
F8237_RS10420	COG0277	FAD linked oxidase domain protein
F8237_RS10435	COG0277	FAD linked oxidase domain protein
F8237_RS10440	COG3474	cytochrome
F8237_RS10465	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F8237_RS10485	COG0604	alcohol dehydrogenase
F8237_RS10495	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F8237_RS10515	COG0583	DNA-binding transcription factor activity
F8237_RS10520	COG1741	Belongs to the pirin family
F8237_RS10525	COG0655	NAD(P)H dehydrogenase (quinone) activity
F8237_RS10545	COG1215	transferase activity, transferring glycosyl groups
F8237_RS10565	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
F8237_RS10570	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F8237_RS10580	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
F8237_RS10590	COG0179	Fumarylacetoacetate (FAA) hydrolase
F8237_RS10610	COG0583	DNA-binding transcription factor activity
F8237_RS10625	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F8237_RS10635	COG1126	abc transporter atp-binding protein
F8237_RS10640	COG0765	amino acid transport
F8237_RS10645	COG0765	amino acid transport
F8237_RS10675	COG1902	pentaerythritol trinitrate reductase activity
F8237_RS10680	COG1012	belongs to the aldehyde dehydrogenase family
F8237_RS10720	COG2205	protein histidine kinase activity
F8237_RS10730	COG4977	sequence-specific DNA binding
F8237_RS10735	COG0840	transmembrane signaling receptor activity
F8237_RS10780	COG0826	peptidase U32
F8237_RS10790	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
F8237_RS10830	COG0483	inositol monophosphate 1-phosphatase activity
F8237_RS10840	COG0583	DNA-binding transcription factor activity
F8237_RS10855	COG1280	lysine exporter protein (LysE YggA)
F8237_RS10865	COG2010	Cytochrome c
F8237_RS10890	COG0067	glutamate synthase
F8237_RS10890	COG0069	glutamate synthase activity
F8237_RS10890	COG0070	glutamate synthase
F8237_RS10930	COG0330	HflC and HflK could
F8237_RS10935	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F8237_RS10945	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
F8237_RS10980	COG0251	oxidation-reduction process
F8237_RS11010	COG0523	cobalamin synthesis protein
F8237_RS11015	COG0803	Belongs to the bacterial solute-binding protein 9 family
F8237_RS11020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F8237_RS11025	COG1121	(ABC) transporter
F8237_RS11045	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F8237_RS11105	COG0318	PFAM AMP-dependent synthetase and ligase
F8237_RS11125	COG0326	Molecular chaperone. Has ATPase activity
F8237_RS11140	COG0784	Response regulator, receiver
F8237_RS11155	COG0778	Nitroreductase
F8237_RS11160	COG1960	acyl-CoA dehydrogenase activity
F8237_RS11165	COG1960	acyl-CoA dehydrogenase activity
F8237_RS11170	COG1960	acyl-CoA dehydrogenase activity
F8237_RS11195	COG0183	Belongs to the thiolase family
F8237_RS11200	COG0318	PFAM AMP-dependent synthetase and ligase
F8237_RS11210	COG2267	carboxylic ester hydrolase activity
F8237_RS11220	COG2186	Transcriptional regulator
F8237_RS11225	COG5285	phytanoyl-CoA dioxygenase
F8237_RS11235	COG2358	TRAP transporter, solute receptor (TAXI family
F8237_RS11255	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
F8237_RS11260	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
F8237_RS11295	COG0739	heme binding
F8237_RS11300	COG0542	response to heat
F8237_RS11320	COG2813	Specifically methylates the guanine in position
F8237_RS11320	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F8237_RS11325	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F8237_RS11335	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F8237_RS11340	COG0287	Prephenate dehydrogenase
F8237_RS11380	COG2884	Cell division ATP-binding protein ftsE
F8237_RS11390	COG2204	response regulator
F8237_RS11405	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F8237_RS11415	COG0019	diaminopimelate decarboxylase activity
F8237_RS11425	COG0165	Argininosuccinate lyase
F8237_RS11430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F8237_RS11440	COG1250	3-hydroxyacyl-CoA dehydrogenase
F8237_RS11445	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
F8237_RS11450	COG2086	electron transfer activity
F8237_RS11475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F8237_RS11500	COG2273	Hydrolase Family 16
F8237_RS11500	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
F8237_RS11510	COG3360	Dodecin
F8237_RS11525	COG4608	Belongs to the ABC transporter superfamily
F8237_RS11530	COG0444	Belongs to the ABC transporter superfamily
F8237_RS11535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F8237_RS11540	COG0601	transmembrane transport
F8237_RS11555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F8237_RS11570	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F8237_RS11570	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F8237_RS11615	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
F8237_RS11670	COG2197	response regulator
F8237_RS11675	COG4585	Histidine kinase
F8237_RS11710	COG2070	2-Nitropropane dioxygenase
F8237_RS11715	COG0318	PFAM AMP-dependent synthetase and ligase
F8237_RS11720	COG4191	Histidine kinase
F8237_RS11720	COG0784	Response regulator, receiver
F8237_RS11725	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
F8237_RS11740	COG1027	Aspartate ammonia-lyase
F8237_RS11750	COG1238	metal cluster binding
F8237_RS11755	COG0140	phosphoribosyl-ATP diphosphatase activity
F8237_RS11770	COG1132	(ABC) transporter
F8237_RS11775	COG1686	Belongs to the peptidase S11 family
F8237_RS11780	COG0318	PFAM AMP-dependent synthetase and ligase
F8237_RS11785	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F8237_RS11785	COG0678	peroxiredoxin activity
F8237_RS11790	COG0328	RNA-DNA hybrid ribonuclease activity
F8237_RS11795	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
F8237_RS11800	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F8237_RS11810	COG3047	cAMP biosynthetic process
F8237_RS11850	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS11870	COG2358	TRAP transporter, solute receptor (TAXI family
F8237_RS11900	COG0667	Aldo Keto reductase
F8237_RS11915	COG4716	Myosin-crossreactive antigen
F8237_RS11920	COG1022	Amp-dependent synthetase and ligase
F8237_RS11925	COG1335	isochorismatase
F8237_RS11950	COG0784	Response regulator, receiver
F8237_RS11950	COG4191	Histidine kinase
F8237_RS11980	COG0438	transferase activity, transferring glycosyl groups
F8237_RS11995	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
F8237_RS12000	COG0424	maF-like protein
F8237_RS12005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F8237_RS12010	COG5328	Belongs to the UPF0262 family
F8237_RS12015	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F8237_RS12025	COG0702	epimerase
F8237_RS12075	COG4948	Mandelate Racemase Muconate Lactonizing
F8237_RS12080	COG0583	DNA-binding transcription factor activity
F8237_RS12085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8237_RS12105	COG3971	2-oxopent-4-enoate hydratase activity
F8237_RS12110	COG0179	Fumarylacetoacetate (FAA) hydrolase
F8237_RS12115	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F8237_RS12120	COG3181	Tripartite tricarboxylate transporter family receptor
F8237_RS12155	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS12170	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
F8237_RS12175	COG3454	Phosphonate metabolism
F8237_RS12180	COG4778	phosphonate C-P lyase system protein PhnL
F8237_RS12185	COG4107	phosphonate C-P lyase system protein PhnK
F8237_RS12190	COG3627	carbon phosphorus lyase activity
F8237_RS12195	COG3626	phosphonate metabolism
F8237_RS12200	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
F8237_RS12205	COG3624	Phosphonate C-P lyase system protein PhnG
F8237_RS12210	COG2188	Transcriptional regulator
F8237_RS12220	COG3639	organic phosphonate transmembrane transporter activity
F8237_RS12230	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
F8237_RS12240	COG3454	Phosphonate metabolism
F8237_RS12245	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
F8237_RS12260	COG1024	Enoyl-CoA hydratase
F8237_RS12270	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
F8237_RS12275	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F8237_RS12300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F8237_RS12305	COG0277	FAD linked oxidase domain protein
F8237_RS12310	COG1802	Transcriptional regulator
F8237_RS12325	COG1032	radical SAM domain protein
F8237_RS12340	COG0583	DNA-binding transcription factor activity
F8237_RS12345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8237_RS12375	COG1024	Enoyl-CoA hydratase
F8237_RS12395	COG3038	cytochrome b561
F8237_RS12410	COG0230	Belongs to the bacterial ribosomal protein bL34 family
F8237_RS12415	COG0594	ribonuclease P activity
F8237_RS12420	COG0706	membrane insertase activity
F8237_RS12425	COG0218	Necessary for normal cell division and for the maintenance of normal septation
F8237_RS12435	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F8237_RS12455	COG2171	N-acyltransferase activity
F8237_RS12470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F8237_RS12475	COG0101	tRNA pseudouridine synthase activity
F8237_RS12480	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F8237_RS12485	COG0242	peptide deformylase activity
F8237_RS12500	COG2223	nitrite transmembrane transporter activity
F8237_RS12510	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F8237_RS12515	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F8237_RS12520	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F8237_RS12535	COG0765	amino acid transport
F8237_RS12540	COG1126	abc transporter atp-binding protein
F8237_RS12565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F8237_RS12570	COG1522	sequence-specific DNA binding
F8237_RS12595	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F8237_RS12600	COG3577	Aspartyl protease
F8237_RS12605	COG1643	Atp-dependent helicase
F8237_RS12610	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F8237_RS12625	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F8237_RS12625	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F8237_RS12635	COG1280	lysine exporter protein (LysE YggA)
F8237_RS12640	COG0625	glutathione transferase activity
F8237_RS12645	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F8237_RS12690	COG0740	serine-type endopeptidase activity
F8237_RS12715	COG1201	RNA secondary structure unwinding
F8237_RS12750	COG0167	dihydroorotate dehydrogenase activity
F8237_RS12770	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
F8237_RS12780	COG1999	signal sequence binding
F8237_RS12800	COG0251	oxidation-reduction process
F8237_RS12830	COG1396	sequence-specific DNA binding
F8237_RS12840	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F8237_RS12880	COG0717	Belongs to the dCTP deaminase family
F8237_RS12905	COG2967	ApaG domain
F8237_RS12925	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F8237_RS12930	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F8237_RS12940	COG0745	RESPONSE REGULATOR receiver
F8237_RS12945	COG0704	Plays a role in the regulation of phosphate uptake
F8237_RS12950	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F8237_RS12955	COG0581	inorganic phosphate transmembrane transporter activity
F8237_RS12960	COG0573	inorganic phosphate transmembrane transporter activity
F8237_RS12965	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F8237_RS12970	COG5002	protein histidine kinase activity
F8237_RS12985	COG1360	Flagellar Motor Protein
F8237_RS13035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F8237_RS13040	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F8237_RS13055	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F8237_RS13055	COG4651	solute:proton antiporter activity
F8237_RS13060	COG1414	Transcriptional regulator
F8237_RS13065	COG4638	Rieske (2fe-2S)
F8237_RS13085	COG4214	carbohydrate transport
F8237_RS13100	COG3916	Acyl-homoserine-lactone synthase
F8237_RS13105	COG2197	response regulator
F8237_RS13115	COG0583	DNA-binding transcription factor activity
F8237_RS13120	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F8237_RS13125	COG1082	Xylose isomerase domain protein TIM barrel
F8237_RS13125	COG3185	4-Hydroxyphenylpyruvate dioxygenase
F8237_RS13135	COG1252	NADH dehydrogenase
F8237_RS13145	COG2124	cytochrome p450
F8237_RS13155	COG0318	PFAM AMP-dependent synthetase and ligase
F8237_RS13170	COG1802	Transcriptional regulator
F8237_RS13210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8237_RS13210	COG4191	Histidine kinase
F8237_RS13215	COG3437	response regulator, receiver
F8237_RS13215	COG0784	Response regulator, receiver
F8237_RS13225	COG1595	DNA-templated transcription, initiation
F8237_RS13240	COG1271	oxidase subunit
F8237_RS13245	COG1294	oxidase, subunit
F8237_RS13265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8237_RS13270	COG1960	acyl-CoA dehydrogenase activity
F8237_RS13275	COG1960	acyl-CoA dehydrogenase activity
F8237_RS13285	COG2514	catechol 2,3-dioxygenase activity
F8237_RS13295	COG2814	Major facilitator Superfamily
F8237_RS13300	COG1505	serine-type exopeptidase activity
F8237_RS13340	COG0737	Belongs to the 5'-nucleotidase family
F8237_RS13355	COG2271	Major facilitator Superfamily
F8237_RS13365	COG2271	Major facilitator Superfamily
F8237_RS13385	COG3788	relative of glutathione S-transferase, MAPEG superfamily
F8237_RS13390	COG0683	leucine binding
F8237_RS13400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F8237_RS13420	COG0601	transmembrane transport
F8237_RS13425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F8237_RS13430	COG0444	Belongs to the ABC transporter superfamily
F8237_RS13435	COG4608	Belongs to the ABC transporter superfamily
F8237_RS13445	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F8237_RS13450	COG3246	L-lysine catabolic process to acetate
F8237_RS13465	COG1960	acyl-CoA dehydrogenase activity
F8237_RS13470	COG1960	acyl-CoA dehydrogenase activity
F8237_RS13540	COG2072	flavoprotein involved in K transport
F8237_RS13550	COG1011	Hydrolase
F8237_RS13555	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
F8237_RS13560	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
F8237_RS13565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F8237_RS13575	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F8237_RS13585	COG5001	Diguanylate cyclase
F8237_RS13605	COG5001	Diguanylate cyclase
F8237_RS13605	COG3300	MHYT domain
F8237_RS13620	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F8237_RS13625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F8237_RS13630	COG0142	geranyltranstransferase activity
F8237_RS13660	COG0025	NhaP-type Na H and K H
F8237_RS13670	COG2175	clavaminate synthase activity
F8237_RS13675	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F8237_RS13685	COG0735	belongs to the Fur family
F8237_RS13695	COG1566	PFAM secretion protein HlyD family protein
F8237_RS13710	COG0840	transmembrane signaling receptor activity
F8237_RS13715	COG3485	protocatechuate 3,4-dioxygenase
F8237_RS13720	COG3485	protocatechuate 3,4-dioxygenase
F8237_RS13730	COG0183	Belongs to the thiolase family
F8237_RS13735	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
F8237_RS13765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F8237_RS13775	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
F8237_RS13825	COG1131	(ABC) transporter
F8237_RS13835	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
F8237_RS13850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F8237_RS13870	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS13880	COG5001	Diguanylate cyclase
F8237_RS13890	COG3829	transcription factor binding
F8237_RS13890	COG3290	protein histidine kinase activity
F8237_RS13920	COG5001	Diguanylate cyclase
F8237_RS13925	COG3706	GGDEF domain
F8237_RS13945	COG0745	RESPONSE REGULATOR receiver
F8237_RS13995	COG4191	Histidine kinase
F8237_RS14000	COG4566	intracellular signal transduction
F8237_RS14015	COG2948	multi-organism process
F8237_RS14030	COG3846	protein secretion by the type IV secretion system
F8237_RS14045	COG3451	type IV secretory pathway VirB4
F8237_RS14060	COG4962	Type ii secretion system protein e
F8237_RS14085	COG0140	phosphoribosyl-ATP diphosphatase activity
F8237_RS14100	COG4191	Histidine kinase
F8237_RS14105	COG4566	intracellular signal transduction
F8237_RS14150	COG1192	Involved in chromosome partitioning
F8237_RS14185	COG5489	Protein of unknown function (DUF736)
F8237_RS14220	COG1475	DNA binding
F8237_RS14285	COG1204	response to ionizing radiation
F8237_RS14295	COG4974	Belongs to the 'phage' integrase family
F8237_RS14305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F8237_RS14335	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F8237_RS14350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F8237_RS14415	COG0412	Dienelactone hydrolase
F8237_RS14425	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F8237_RS14435	COG0268	Binds directly to 16S ribosomal RNA
F8237_RS14445	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F8237_RS14455	COG2852	Protein conserved in bacteria
F8237_RS14460	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F8237_RS14480	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F8237_RS14485	COG0534	Mate efflux family protein
F8237_RS14520	COG1741	Belongs to the pirin family
F8237_RS14525	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F8237_RS14530	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
F8237_RS14530	COG2066	Belongs to the glutaminase family
F8237_RS14540	COG1879	ABC-type sugar transport system periplasmic component
F8237_RS14545	COG5002	protein histidine kinase activity
F8237_RS14545	COG0784	Response regulator, receiver
F8237_RS14545	COG2198	Histidine kinase
F8237_RS14565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F8237_RS14575	COG0180	Tryptophanyl-tRNA synthetase
F8237_RS14595	COG1214	PFAM Peptidase M22, glycoprotease
F8237_RS14610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F8237_RS14615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F8237_RS14620	COG1702	phosphate starvation-inducible protein PhoH
F8237_RS14625	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F8237_RS14630	COG1253	flavin adenine dinucleotide binding
F8237_RS14635	COG0815	Transfers the fatty acyl group on membrane lipoproteins
F8237_RS14640	COG1396	sequence-specific DNA binding
F8237_RS14650	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F8237_RS14660	COG0779	Required for maturation of 30S ribosomal subunits
F8237_RS14675	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F8237_RS14680	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F8237_RS14685	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F8237_RS14690	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F8237_RS14695	COG1185	polyribonucleotide nucleotidyltransferase activity
F8237_RS14705	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
F8237_RS14720	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F8237_RS14730	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F8237_RS14750	COG0583	DNA-binding transcription factor activity
F8237_RS14755	COG0667	Aldo Keto reductase
F8237_RS14760	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F8237_RS14790	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F8237_RS14795	COG2226	methyltransferase
F8237_RS14800	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F8237_RS14805	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F8237_RS14810	COG0756	dUTP diphosphatase activity
F8237_RS14815	COG2205	protein histidine kinase activity
F8237_RS14820	COG3178	'Phosphotransferase
F8237_RS14830	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F8237_RS14840	COG1074	ATP-dependent DNA helicase activity
F8237_RS14860	COG0285	dihydrofolate synthase activity
F8237_RS14865	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F8237_RS14870	COG0159	tryptophan synthase activity
F8237_RS14875	COG0133	tryptophan synthase activity
F8237_RS14880	COG0135	phosphoribosylanthranilate isomerase activity
F8237_RS14890	COG0776	regulation of translation
F8237_RS14895	COG0616	signal peptide processing
F8237_RS14900	COG0539	negative regulation of cytoplasmic translation
F8237_RS14905	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F8237_RS14910	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F8237_RS14930	COG1846	Transcriptional regulator
F8237_RS14935	COG1764	response to oxidative stress
F8237_RS14955	COG0395	ABC-type sugar transport system, permease component
F8237_RS14960	COG3842	ATPase activity
F8237_RS14965	COG0071	Belongs to the small heat shock protein (HSP20) family
F8237_RS14980	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8237_RS14985	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F8237_RS14990	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
F8237_RS14995	COG1137	ATPase activity
F8237_RS15000	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
F8237_RS15015	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
F8237_RS15020	COG2814	Major facilitator Superfamily
F8237_RS15065	COG0277	FAD linked oxidase domain protein
F8237_RS15070	COG1968	undecaprenyl-diphosphatase activity
F8237_RS15080	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F8237_RS15100	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F8237_RS15110	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F8237_RS15115	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F8237_RS15125	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F8237_RS15130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F8237_RS15130	COG0072	phenylalanine-tRNA ligase activity
F8237_RS15150	COG1937	Protein conserved in bacteria
F8237_RS15160	COG0864	Transcriptional regulator
F8237_RS15180	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F8237_RS15190	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F8237_RS15195	COG0588	phosphoglycerate mutase activity
F8237_RS15200	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F8237_RS15210	COG0284	orotidine-5'-phosphate decarboxylase activity
F8237_RS15220	COG3963	phosphatidate phosphatase activity
F8237_RS15225	COG0484	heat shock protein binding
F8237_RS15235	COG0443	Heat shock 70 kDa protein
F8237_RS15245	COG1335	isochorismatase
F8237_RS15250	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F8237_RS15260	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F8237_RS15265	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F8237_RS15270	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F8237_RS15280	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
F8237_RS15285	COG0792	nuclease activity
F8237_RS15290	COG0189	ligase activity
F8237_RS15300	COG4964	Belongs to the GSP D family
F8237_RS15335	COG5002	protein histidine kinase activity
F8237_RS15335	COG2205	protein histidine kinase activity
F8237_RS15335	COG0784	Response regulator, receiver
F8237_RS15340	COG1072	(Pantothenic acid kinase))
F8237_RS15345	COG0140	phosphoribosyl-ATP diphosphatase activity
F8237_RS15350	COG0107	imidazoleglycerol-phosphate synthase activity
F8237_RS15355	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F8237_RS15360	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F8237_RS15370	COG0131	Imidazoleglycerol-phosphate dehydratase
F8237_RS15375	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
F8237_RS15385	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
F8237_RS15400	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
F8237_RS15410	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
F8237_RS15415	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F8237_RS15420	COG0237	dephospho-CoA kinase activity
F8237_RS15425	COG0424	maF-like protein
F8237_RS15430	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
F8237_RS15440	COG1981	membrane
F8237_RS15445	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
F8237_RS15450	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
F8237_RS15455	COG0445	tRNA wobble uridine modification
F8237_RS15460	COG0357	Ribosomal RNA small subunit methyltransferase G
F8237_RS15490	COG3706	GGDEF domain
F8237_RS15495	COG2203	Gaf domain
F8237_RS15495	COG3706	GGDEF domain
F8237_RS15495	COG4251	negative regulation of phosphorylation
F8237_RS15495	COG5001	Diguanylate cyclase
F8237_RS15515	COG0745	RESPONSE REGULATOR receiver
F8237_RS15530	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
F8237_RS15535	COG1674	ftsk spoiiie
F8237_RS15540	COG0436	Aminotransferase
F8237_RS15550	COG0004	ammonium transporteR
F8237_RS15555	COG0347	Belongs to the P(II) protein family
F8237_RS15560	COG0740	serine-type endopeptidase activity
F8237_RS15570	COG0640	Transcriptional regulator
F8237_RS15575	COG0004	ammonium transporteR
F8237_RS15580	COG0347	Belongs to the P(II) protein family
F8237_RS15590	COG1946	Acyl-CoA thioesterase
F8237_RS15595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F8237_RS15600	COG2835	tetraacyldisaccharide 4'-kinase activity
F8237_RS15625	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F8237_RS15630	COG3118	belongs to the thioredoxin family
F8237_RS15640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F8237_RS15660	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F8237_RS15670	COG0534	Mate efflux family protein
F8237_RS15685	COG2814	Major facilitator Superfamily
F8237_RS15690	COG0405	Gamma-glutamyltransferase
F8237_RS15700	COG0138	bifunctional purine biosynthesis protein purh
F8237_RS15730	COG1376	ErfK ybiS ycfS ynhG family protein
F8237_RS15735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F8237_RS15760	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F8237_RS15765	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F8237_RS15815	COG2814	Major facilitator Superfamily
F8237_RS15840	COG4221	oxidoreductase activity
F8237_RS15845	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F8237_RS15850	COG1024	Enoyl-CoA hydratase
F8237_RS15865	COG1872	DUF167
F8237_RS15870	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F8237_RS15875	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F8237_RS15880	COG1247	-acetyltransferase
F8237_RS15890	COG3011	Protein conserved in bacteria
F8237_RS15900	COG1217	gtp-binding protein TYPA
F8237_RS15910	COG0784	Response regulator, receiver
F8237_RS15925	COG2154	pterin-4-alpha-carbinolamine dehydratase
F8237_RS15950	COG0604	alcohol dehydrogenase
F8237_RS15950	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS15950	COG3321	synthase
F8237_RS15955	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS15965	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F8237_RS15975	COG0671	phosphoesterase, PA-phosphatase related
F8237_RS15980	COG0137	argininosuccinate synthase activity
F8237_RS15985	COG1785	Belongs to the alkaline phosphatase family
F8237_RS16010	COG4178	(ABC) transporter
F8237_RS16035	COG0730	response to heat
F8237_RS16040	COG0318	PFAM AMP-dependent synthetase and ligase
F8237_RS16045	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS16050	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
F8237_RS16055	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
F8237_RS16060	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F8237_RS16070	COG0473	3-isopropylmalate dehydrogenase activity
F8237_RS16085	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F8237_RS16090	COG0288	reversible hydration of carbon dioxide
F8237_RS16095	COG2301	Belongs to the HpcH HpaI aldolase family
F8237_RS16100	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS16105	COG2207	Transcriptional regulator
F8237_RS16130	COG0066	3-isopropylmalate dehydratase activity
F8237_RS16155	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F8237_RS16160	COG0335	large ribosomal subunit rRNA binding
F8237_RS16165	COG0336	Belongs to the RNA methyltransferase TrmD family
F8237_RS16170	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F8237_RS16175	COG0228	four-way junction DNA binding
F8237_RS16180	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F8237_RS16200	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F8237_RS16205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F8237_RS16215	COG0564	pseudouridine synthase activity
F8237_RS16220	COG0552	protein localization to endoplasmic reticulum
F8237_RS16225	COG2917	probably involved in intracellular septation
F8237_RS16235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F8237_RS16245	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F8237_RS16250	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F8237_RS16255	COG4133	protoheme IX ABC transporter activity
F8237_RS16260	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
F8237_RS16280	COG0670	Belongs to the BI1 family
F8237_RS16285	COG1136	(ABC) transporter
F8237_RS16285	COG0577	efflux transmembrane transporter activity
F8237_RS16290	COG4181	ATPase activity
F8237_RS16295	COG2755	lipolytic protein G-D-S-L family
F8237_RS16300	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
F8237_RS16305	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
F8237_RS16310	COG0039	L-malate dehydrogenase activity
F8237_RS16315	COG0045	succinate-CoA ligase (ADP-forming) activity
F8237_RS16325	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
F8237_RS16335	COG0508	dehydrogenase complex catalyzes the overall conversion of
F8237_RS16340	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS16345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F8237_RS16360	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
F8237_RS16370	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F8237_RS16375	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F8237_RS16380	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F8237_RS16385	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F8237_RS16390	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F8237_RS16395	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F8237_RS16405	COG0494	nUDIX hydrolase
F8237_RS16410	COG1051	belongs to the nudix hydrolase family
F8237_RS16420	COG0793	Belongs to the peptidase S41A family
F8237_RS16430	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
F8237_RS16435	COG0799	negative regulation of ribosome biogenesis
F8237_RS16440	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F8237_RS16445	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F8237_RS16455	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F8237_RS16470	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F8237_RS16485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F8237_RS16490	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F8237_RS16495	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F8237_RS16560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F8237_RS16565	COG0697	spore germination
F8237_RS16610	COG2198	Histidine kinase
F8237_RS16610	COG0784	Response regulator, receiver
F8237_RS16610	COG0643	Histidine kinase
F8237_RS16615	COG0835	chemotaxis
F8237_RS16620	COG0745	RESPONSE REGULATOR receiver
F8237_RS16635	COG2201	protein-glutamate methylesterase activity
F8237_RS16645	COG4566	intracellular signal transduction
F8237_RS16650	COG4191	Histidine kinase
F8237_RS16650	COG0784	Response regulator, receiver
F8237_RS16655	COG4566	intracellular signal transduction
F8237_RS16685	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F8237_RS16700	COG1696	Membrane protein involved in D-alanine export
F8237_RS16710	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F8237_RS16735	COG2706	6-phosphogluconolactonase activity
F8237_RS16765	COG0828	Belongs to the bacterial ribosomal protein bS21 family
F8237_RS16770	COG5001	Diguanylate cyclase
F8237_RS16790	COG1002	Type II restriction enzyme, methylase subunits
F8237_RS16800	COG1061	Type III restriction enzyme res subunit
F8237_RS16805	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F8237_RS16825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F8237_RS16860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F8237_RS16875	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
F8237_RS16885	COG3813	Protein conserved in bacteria
F8237_RS16890	COG1522	sequence-specific DNA binding
F8237_RS16900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F8237_RS16930	COG0477	Major facilitator Superfamily
F8237_RS16935	COG1877	trehalose-phosphatase activity
F8237_RS16940	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
F8237_RS16960	COG4717	serine-type aminopeptidase activity
F8237_RS16965	COG0420	3'-5' exonuclease activity
F8237_RS17000	COG1475	DNA binding
F8237_RS17010	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
F8237_RS17010	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
F8237_RS17030	COG1074	ATP-dependent DNA helicase activity
F8237_RS17100	COG0583	DNA-binding transcription factor activity
F8237_RS17105	COG2814	Major facilitator Superfamily
F8237_RS17110	COG0154	amidase activity
F8237_RS17120	COG2873	o-acetylhomoserine
F8237_RS17135	COG0514	ATP-dependent DNA helicase (RecQ)
F8237_RS17145	COG2515	1-aminocyclopropane-1-carboxylate deaminase
F8237_RS17150	COG1522	sequence-specific DNA binding
F8237_RS17155	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F8237_RS17175	COG0657	acetylesterase activity
F8237_RS17180	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F8237_RS17190	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
F8237_RS17215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F8237_RS17230	COG2890	protein-(glutamine-N5) methyltransferase activity
F8237_RS17235	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F8237_RS17240	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
F8237_RS17245	COG0527	aspartate kinase activity
F8237_RS17255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F8237_RS17270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F8237_RS17280	COG1040	competence protein
F8237_RS17295	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F8237_RS17300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F8237_RS17305	COG0653	protein targeting
F8237_RS17330	COG3034	peptidoglycan biosynthetic process
F8237_RS17335	COG0825	malonyl-CoA metabolic process
F8237_RS17340	COG4974	Belongs to the 'phage' integrase family
F8237_RS17350	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F8237_RS17355	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F8237_RS17360	COG4536	flavin adenine dinucleotide binding
F8237_RS17365	COG0271	Belongs to the BolA IbaG family
F8237_RS17375	COG0372	Belongs to the citrate synthase family
F8237_RS17380	COG0372	Belongs to the citrate synthase family
F8237_RS17405	COG1902	pentaerythritol trinitrate reductase activity
F8237_RS17445	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F8237_RS17450	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F8237_RS17470	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
F8237_RS17475	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
F8237_RS17500	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
F8237_RS17515	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
F8237_RS17520	COG1845	cytochrome c oxidase, subunit III
F8237_RS17525	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F8237_RS17530	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F8237_RS17535	COG0477	Major facilitator Superfamily
F8237_RS17555	COG1024	Enoyl-CoA hydratase
F8237_RS17565	COG1024	Enoyl-CoA hydratase
F8237_RS17570	COG1960	acyl-CoA dehydrogenase activity
F8237_RS17585	COG2261	transglycosylase associated protein
F8237_RS17595	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F8237_RS17620	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F8237_RS17665	COG3384	dioxygenase
F8237_RS17675	COG0431	NADPH-dependent FMN reductase
F8237_RS17690	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
F8237_RS17695	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS17715	COG2860	membrane
F8237_RS17755	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS17805	COG1741	Belongs to the pirin family
F8237_RS17810	COG2814	Major facilitator Superfamily
F8237_RS17825	COG2010	Cytochrome c
F8237_RS17825	COG4993	Dehydrogenase
F8237_RS17840	COG1473	amidohydrolase
F8237_RS17845	COG2860	membrane
F8237_RS17870	COG2020	methyltransferase activity
F8237_RS17900	COG3964	amidohydrolase
F8237_RS17905	COG1960	acyl-CoA dehydrogenase activity
F8237_RS17920	COG1024	Enoyl-CoA hydratase
F8237_RS17925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F8237_RS17980	COG2130	NADP-dependent
F8237_RS17995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8237_RS18010	COG0069	glutamate synthase activity
F8237_RS18020	COG1253	flavin adenine dinucleotide binding
F8237_RS18040	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
F8237_RS18065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F8237_RS18070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F8237_RS18120	COG0129	dihydroxy-acid dehydratase activity
F8237_RS18125	COG0418	dihydroorotase activity
F8237_RS18135	COG0285	dihydrofolate synthase activity
F8237_RS18160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F8237_RS18165	COG3002	Belongs to the UPF0753 family
F8237_RS18185	COG0583	DNA-binding transcription factor activity
F8237_RS18195	COG2948	multi-organism process
F8237_RS18210	COG3846	protein secretion by the type IV secretion system
F8237_RS18225	COG3451	type IV secretory pathway VirB4
F8237_RS18235	COG3838	Conjugal transfer protein Trbc
F8237_RS18240	COG4962	Type ii secretion system protein e
F8237_RS18255	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F8237_RS18275	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F8237_RS18300	COG0741	lytic transglycosylase activity
F8237_RS18325	COG1192	Involved in chromosome partitioning
F8237_RS18360	COG1476	TRANSCRIPTIONal
F8237_RS18415	COG5489	Protein of unknown function (DUF736)
F8237_RS18470	COG0640	Transcriptional regulator
F8237_RS18525	COG0784	Response regulator, receiver
F8237_RS18525	COG4191	Histidine kinase
F8237_RS18530	COG0745	RESPONSE REGULATOR receiver
F8237_RS18560	COG0210	DNA helicase
F8237_RS18570	COG3177	Filamentation induced by cAMP protein fic
F8237_RS18605	COG2003	Belongs to the UPF0758 family
F8237_RS18615	COG0024	Methionine aminopeptidase
F8237_RS18620	COG3264	Mechanosensitive ion channel
F8237_RS18620	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
F8237_RS18625	COG3263	regulation of cellular component size
F8237_RS18630	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
F8237_RS18635	COG4149	molybdate abc transporter
F8237_RS18640	COG0725	ABC transporter, periplasmic molybdate-binding protein
F8237_RS18650	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
F8237_RS18655	COG5001	Diguanylate cyclase
F8237_RS18700	COG0481	GTPase activity
F8237_RS18715	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8237_RS18715	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8237_RS18720	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F8237_RS18725	COG2205	protein histidine kinase activity
F8237_RS18730	COG0745	RESPONSE REGULATOR receiver
F8237_RS18745	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
F8237_RS18755	COG0058	SHG alpha-glucan phosphorylase activity
F8237_RS18775	COG0625	glutathione transferase activity
F8237_RS18790	COG1024	Enoyl-CoA hydratase
F8237_RS18790	COG1250	3-hydroxyacyl-CoA dehydrogenase
F8237_RS18795	COG0183	Belongs to the thiolase family
F8237_RS18800	COG1960	acyl-CoA dehydrogenase activity
F8237_RS18810	COG1695	Transcriptional regulator
F8237_RS18825	COG0730	response to heat
F8237_RS18845	COG0583	DNA-binding transcription factor activity
F8237_RS18855	COG0681	Belongs to the peptidase S26 family
F8237_RS18860	COG0312	modulator of DNA gyrase
F8237_RS18880	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F8237_RS18885	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F8237_RS18890	COG0109	protoheme IX farnesyltransferase activity
F8237_RS18900	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
F8237_RS18915	COG3346	SURF1 family
F8237_RS18940	COG0612	Peptidase, M16
F8237_RS18945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F8237_RS18955	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F8237_RS18960	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F8237_RS18970	COG0356	it plays a direct role in the translocation of protons across the membrane
F8237_RS18990	COG0432	Pfam Uncharacterised protein family UPF0047
F8237_RS19010	COG2205	protein histidine kinase activity
F8237_RS19010	COG0784	Response regulator, receiver
F8237_RS19015	COG0156	8-amino-7-oxononanoate synthase activity
F8237_RS19075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F8237_RS19080	COG0601	transmembrane transport
F8237_RS19120	COG2020	methyltransferase activity
F8237_RS19135	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F8237_RS19140	COG2309	aminopeptidase activity
F8237_RS19225	COG0747	negative chemotaxis
F8237_RS19230	COG0747	negative chemotaxis
F8237_RS19240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F8237_RS19245	COG4608	Belongs to the ABC transporter superfamily
F8237_RS19255	COG0154	amidase activity
F8237_RS19260	COG0444	Belongs to the ABC transporter superfamily
F8237_RS19270	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
F8237_RS19275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F8237_RS19280	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F8237_RS19290	COG1058	Belongs to the CinA family
F8237_RS19290	COG1546	Belongs to the CinA family
F8237_RS19315	COG0583	DNA-binding transcription factor activity
F8237_RS19330	COG1024	Enoyl-CoA hydratase
F8237_RS19335	COG4221	oxidoreductase activity
F8237_RS19345	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
F8237_RS19370	COG2267	carboxylic ester hydrolase activity
F8237_RS19385	COG0179	Fumarylacetoacetate (FAA) hydrolase
F8237_RS19405	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS19415	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS19435	COG0640	Transcriptional regulator
F8237_RS19440	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS19490	COG1129	ABC transporter
F8237_RS19490	COG0842	Transport permease protein
F8237_RS19495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F8237_RS19510	COG2207	Transcriptional regulator
F8237_RS19510	COG1917	Cupin 2, conserved barrel domain protein
F8237_RS19525	COG1063	alcohol dehydrogenase
F8237_RS19530	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F8237_RS19560	COG2378	regulation of single-species biofilm formation
F8237_RS19570	COG1024	Enoyl-CoA hydratase
F8237_RS19575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F8237_RS19635	COG1022	Amp-dependent synthetase and ligase
F8237_RS19635	COG3320	Male sterility
F8237_RS19640	COG1024	Enoyl-CoA hydratase
F8237_RS19680	COG0583	DNA-binding transcription factor activity
F8237_RS19765	COG0318	PFAM AMP-dependent synthetase and ligase
F8237_RS19770	COG1960	acyl-CoA dehydrogenase activity
F8237_RS19780	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS19785	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F8237_RS19825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8237_RS19830	COG1605	Chorismate mutase
F8237_RS19830	COG0077	Prephenate dehydratase
F8237_RS19835	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
F8237_RS19840	COG3474	cytochrome
F8237_RS19845	COG4166	transmembrane transport
F8237_RS19850	COG4166	transmembrane transport
F8237_RS19855	COG4174	ABC transporter (Permease)
F8237_RS19860	COG4239	(ABC) transporter, permease
F8237_RS19865	COG4172	Belongs to the ABC transporter superfamily
F8237_RS19875	COG0791	NLP P60 protein
F8237_RS19880	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F8237_RS19925	COG4964	Belongs to the GSP D family
F8237_RS19955	COG1278	Cold shock
F8237_RS19960	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F8237_RS19965	COG0513	Belongs to the DEAD box helicase family
F8237_RS19995	COG0829	nickel cation binding
F8237_RS20000	COG0831	urea catabolic process
F8237_RS20005	COG0832	Belongs to the urease beta subunit family
F8237_RS20010	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F8237_RS20020	COG0804	urea catabolic process
F8237_RS20035	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
F8237_RS20040	COG0830	nickel cation binding
F8237_RS20045	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
F8237_RS20075	COG0628	permease
F8237_RS20080	COG1388	LysM domain
F8237_RS20080	COG1376	ErfK ybiS ycfS ynhG family protein
F8237_RS20105	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
F8237_RS20115	COG0175	sulfate reduction
F8237_RS20120	COG1648	precorrin-2 dehydrogenase activity
F8237_RS20120	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F8237_RS20130	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F8237_RS20140	COG0175	sulfate reduction
F8237_RS20145	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
F8237_RS20150	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
F8237_RS20155	COG4208	sulfate ABC transporter
F8237_RS20160	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
F8237_RS20175	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS20185	COG0730	response to heat
F8237_RS20200	COG1678	Uncharacterized ACR, COG1678
F8237_RS20210	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS20215	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS20220	COG3237	CsbD-like
F8237_RS20230	COG2951	lytic endotransglycosylase activity
F8237_RS20245	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F8237_RS20255	COG5001	Diguanylate cyclase
F8237_RS20255	COG4251	negative regulation of phosphorylation
F8237_RS20255	COG3706	GGDEF domain
F8237_RS20255	COG2203	Gaf domain
F8237_RS20290	COG0254	rRNA binding
F8237_RS20295	COG1132	(ABC) transporter
F8237_RS20305	COG3609	addiction module antidote protein, CC2985 family
F8237_RS20335	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F8237_RS20340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F8237_RS20350	COG0454	-acetyltransferase
F8237_RS20355	COG0483	inositol monophosphate 1-phosphatase activity
F8237_RS20370	COG3588	fructose-bisphosphate aldolase
F8237_RS20385	COG0126	phosphoglycerate kinase activity
F8237_RS20420	COG1692	metallophosphoesterase
F8237_RS20450	COG0840	transmembrane signaling receptor activity
F8237_RS20460	COG0217	transcriptional regulatory protein
F8237_RS20465	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
F8237_RS20470	COG0632	four-way junction helicase activity
F8237_RS20480	COG2255	four-way junction helicase activity
F8237_RS20485	COG1408	metallophosphoesterase
F8237_RS20490	COG0824	Thioesterase
F8237_RS20500	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F8237_RS20500	COG0519	Catalyzes the synthesis of GMP from XMP
F8237_RS20525	COG3842	ATPase activity
F8237_RS20530	COG1176	ABC-type spermidine putrescine transport system, permease component I
F8237_RS20535	COG1177	transmembrane transport
F8237_RS20565	COG1301	dicarboxylic acid transport
F8237_RS20570	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS20590	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F8237_RS20615	COG0625	glutathione transferase activity
F8237_RS20620	COG1309	transcriptional regulator
F8237_RS20625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F8237_RS20630	COG3795	YCII-related domain
F8237_RS20635	COG4941	Belongs to the sigma-70 factor family
F8237_RS20670	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS20710	COG1045	serine acetyltransferase
F8237_RS20735	COG0823	Involved in the tonB-independent uptake of proteins
F8237_RS20740	COG5001	Diguanylate cyclase
F8237_RS20750	COG2885	chlorophyll binding
F8237_RS20760	COG0037	tRNA processing
F8237_RS20765	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F8237_RS20770	COG0784	Response regulator, receiver
F8237_RS20770	COG4191	Histidine kinase
F8237_RS20785	COG2226	methyltransferase
F8237_RS20790	COG0463	Glycosyl transferase, family 2
F8237_RS20805	COG1309	transcriptional regulator
F8237_RS20810	COG0469	pyruvate kinase activity
F8237_RS20825	COG3750	Belongs to the UPF0335 family
F8237_RS20830	COG3108	Peptidase M15
F8237_RS20835	COG2989	Protein conserved in bacteria
F8237_RS20840	COG2204	response regulator
F8237_RS20875	COG0387	Pfam Sodium calcium exchanger
F8237_RS20895	COG0828	Belongs to the bacterial ribosomal protein bS21 family
F8237_RS20900	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F8237_RS20905	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
F8237_RS20910	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F8237_RS20915	COG5001	Diguanylate cyclase
F8237_RS20915	COG3447	MASE1 domain protein
F8237_RS20915	COG5002	protein histidine kinase activity
F8237_RS20950	COG5001	Diguanylate cyclase
F8237_RS20950	COG3300	MHYT domain
F8237_RS20975	COG3842	ATPase activity
F8237_RS20980	COG1176	ABC-type spermidine putrescine transport system, permease component I
F8237_RS20985	COG1177	transmembrane transport
F8237_RS21000	COG1175	transmembrane transport
F8237_RS21040	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F8237_RS21065	COG4566	intracellular signal transduction
F8237_RS21075	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
F8237_RS21080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F8237_RS21105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F8237_RS21110	COG0395	ABC-type sugar transport system, permease component
F8237_RS21115	COG1175	transmembrane transport
F8237_RS21125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F8237_RS21170	COG4591	ABC-type transport system involved in lipoprotein release permease component
F8237_RS21175	COG1136	(ABC) transporter
F8237_RS21180	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F8237_RS21220	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F8237_RS21225	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F8237_RS21235	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F8237_RS21240	COG3005	denitrification pathway
F8237_RS21245	COG3043	anaerobic respiration
F8237_RS21250	COG0243	molybdopterin cofactor binding
F8237_RS21265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8237_RS21290	COG3258	Cytochrome c
F8237_RS21300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F8237_RS21305	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F8237_RS21310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8237_RS21315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F8237_RS21320	COG1116	anion transmembrane transporter activity
F8237_RS21325	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F8237_RS21330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F8237_RS21335	COG2204	response regulator
F8237_RS21340	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F8237_RS21350	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F8237_RS21355	COG1766	The M ring may be actively involved in energy transduction
F8237_RS21365	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
F8237_RS21375	COG0482	sulfurtransferase activity
F8237_RS21450	COG1205	dead DEAH box helicase
F8237_RS21450	COG1111	helicase
F8237_RS21475	COG2226	methyltransferase
F8237_RS21500	COG1959	2 iron, 2 sulfur cluster binding
F8237_RS21510	COG2151	metal-sulfur cluster biosynthetic enzyme
F8237_RS21530	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
F8237_RS21610	COG2863	cytochrome
F8237_RS21615	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F8237_RS21665	COG0348	domain, Protein
F8237_RS21710	COG4263	nitrous-oxide reductase activity
F8237_RS21730	COG2203	Gaf domain
F8237_RS21730	COG3706	GGDEF domain
F8237_RS21730	COG5001	Diguanylate cyclase
F8237_RS21730	COG4251	negative regulation of phosphorylation
F8237_RS21825	COG1937	Protein conserved in bacteria
F8237_RS21845	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F8237_RS21880	COG1611	Belongs to the LOG family
F8237_RS21885	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
F8237_RS21920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F8237_RS21920	COG1017	nitric oxide dioxygenase activity
F8237_RS21980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F8237_RS22005	COG0672	)-iron permease
F8237_RS22070	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F8237_RS22095	COG1538	Outer membrane efflux protein
F8237_RS22115	COG0156	8-amino-7-oxononanoate synthase activity
F8237_RS22165	COG1464	Belongs to the NlpA lipoprotein family
F8237_RS22170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8237_RS22195	COG0411	ABC transporter
F8237_RS22205	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
F8237_RS22265	COG1846	Transcriptional regulator
F8237_RS22270	COG1157	protein secretion by the type III secretion system
F8237_RS22275	COG4786	Flagellar basal body rod
F8237_RS22285	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
F8237_RS22300	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F8237_RS22305	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F8237_RS22310	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F8237_RS22315	COG1815	bacterial-type flagellum-dependent cell motility
F8237_RS22320	COG1558	bacterial-type flagellum-dependent cell motility
F8237_RS22325	COG1677	Flagellar hook-basal body complex protein FliE
F8237_RS22330	COG4786	Flagellar basal body rod
F8237_RS22340	COG1706	bacterial-type flagellum-dependent cell motility
F8237_RS22350	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
F8237_RS22360	COG1338	Plays a role in the flagellum-specific transport system
F8237_RS22365	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F8237_RS22370	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F8237_RS22375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F8237_RS22390	COG1360	Flagellar Motor Protein
F8237_RS22410	COG1749	Flagellar hook protein flgE
F8237_RS22430	COG5443	negative regulation of bacterial-type flagellum assembly
F8237_RS22435	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
F8237_RS22440	COG4794	Type iii secretion
F8237_RS22445	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F8237_RS22450	COG1684	flagellar biosynthetic protein fliR
F8237_RS22495	COG0412	Dienelactone hydrolase
F8237_RS22520	COG0246	Mannitol dehydrogenase
F8237_RS22530	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F8237_RS22540	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
F8237_RS22545	COG1063	alcohol dehydrogenase
F8237_RS22565	COG0583	DNA-binding transcription factor activity
F8237_RS22580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F8237_RS22590	COG1176	ABC-type spermidine putrescine transport system, permease component I
F8237_RS22595	COG4208	sulfate ABC transporter
F8237_RS22605	COG1309	transcriptional regulator
F8237_RS22610	COG0477	Major facilitator Superfamily
F8237_RS22615	COG2272	Belongs to the type-B carboxylesterase lipase family
F8237_RS22635	COG0765	amino acid transport
F8237_RS22645	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F8237_RS22650	COG0251	oxidation-reduction process
F8237_RS22655	COG0436	Aminotransferase
F8237_RS22660	COG0028	Belongs to the TPP enzyme family
F8237_RS22665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F8237_RS22685	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
F8237_RS22685	COG0028	Belongs to the TPP enzyme family
F8237_RS22690	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS22695	COG1414	Transcriptional regulator
F8237_RS22710	COG0583	DNA-binding transcription factor activity
F8237_RS22725	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F8237_RS22745	COG2030	dehydratase
F8237_RS22755	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
F8237_RS22780	COG0427	acetyl-CoA hydrolase
F8237_RS22805	COG0318	PFAM AMP-dependent synthetase and ligase
F8237_RS22825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F8237_RS22850	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
F8237_RS22855	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
F8237_RS22860	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
F8237_RS22865	COG2205	protein histidine kinase activity
F8237_RS22875	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
F8237_RS22900	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F8237_RS22910	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F8237_RS22915	COG0366	Alpha amylase catalytic
F8237_RS22920	COG0366	Alpha amylase catalytic
F8237_RS22925	COG1640	4-alpha-glucanotransferase
F8237_RS22930	COG3387	PFAM Glycoside hydrolase 15-related
F8237_RS22940	COG3265	gluconokinase activity
F8237_RS22945	COG0363	glucosamine-6-phosphate deaminase activity
F8237_RS22950	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F8237_RS22955	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
F8237_RS22960	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F8237_RS22970	COG2766	serine protein kinase
F8237_RS22975	COG2718	Belongs to the UPF0229 family
F8237_RS22980	COG2719	SpoVR family
F8237_RS23015	COG1013	pyruvate-flavodoxin oxidoreductase activity
F8237_RS23020	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
F8237_RS23020	COG0674	pyruvate-flavodoxin oxidoreductase activity
F8237_RS23040	COG0535	radical SAM domain protein
F8237_RS23045	COG0535	radical SAM domain protein
F8237_RS23050	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
F8237_RS23055	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
F8237_RS23070	COG0154	amidase activity
F8237_RS23075	COG0386	Belongs to the glutathione peroxidase family
F8237_RS23135	COG0747	negative chemotaxis
F8237_RS23140	COG0601	transmembrane transport
F8237_RS23145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F8237_RS23150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F8237_RS23155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F8237_RS23200	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
F8237_RS23215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F8237_RS23230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F8237_RS23235	COG2897	thiosulfate sulfurtransferase activity
F8237_RS23245	COG1376	ErfK ybiS ycfS ynhG family protein
F8237_RS23250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F8237_RS23290	COG2193	ferroxidase activity
F8237_RS23310	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F8237_RS23335	COG2204	response regulator
F8237_RS23340	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS23405	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
F8237_RS23420	COG2022	thiamine diphosphate biosynthetic process
F8237_RS23495	COG1177	transmembrane transport
F8237_RS23500	COG1176	ABC-type spermidine putrescine transport system, permease component I
F8237_RS23510	COG3842	ATPase activity
F8237_RS23540	COG1388	LysM domain
F8237_RS23540	COG1376	ErfK ybiS ycfS ynhG family protein
F8237_RS23565	COG0688	phosphatidylethanolamine metabolic process
F8237_RS23620	COG1309	transcriptional regulator
F8237_RS23635	COG5265	(ABC) transporter
F8237_RS23670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F8237_RS23685	COG3795	YCII-related domain
F8237_RS23690	COG4941	Belongs to the sigma-70 factor family
F8237_RS23700	COG3023	N-Acetylmuramoyl-L-alanine amidase
F8237_RS23705	COG0275	rRNA processing
F8237_RS23720	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F8237_RS23725	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F8237_RS23730	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F8237_RS23735	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F8237_RS23745	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F8237_RS23750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F8237_RS23755	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F8237_RS23760	COG1181	Belongs to the D-alanine--D-alanine ligase family
F8237_RS23765	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F8237_RS23770	COG0849	cell division
F8237_RS23775	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F8237_RS23785	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F8237_RS23795	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F8237_RS23800	COG2814	Major facilitator Superfamily
F8237_RS23805	COG0006	proline dipeptidase activity
F8237_RS23805	COG0006	proline dipeptidase activity
F8237_RS23815	COG2264	protein methyltransferase activity
F8237_RS23840	COG0584	glycerophosphoryl diester phosphodiesterase
F8237_RS23860	COG0842	Transport permease protein
F8237_RS23865	COG1131	(ABC) transporter
F8237_RS23915	COG0071	Belongs to the small heat shock protein (HSP20) family
F8237_RS23920	COG0071	Belongs to the small heat shock protein (HSP20) family
F8237_RS23940	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
F8237_RS23980	COG0210	DNA helicase
F8237_RS23985	COG5487	UPF0391 membrane protein
F8237_RS23995	COG0277	FAD linked oxidase domain protein
F8237_RS24015	COG0583	DNA-binding transcription factor activity
F8237_RS24020	COG2259	Doxx family
F8237_RS24025	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F8237_RS24035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F8237_RS24045	COG5001	Diguanylate cyclase
F8237_RS24045	COG3300	MHYT domain
F8237_RS24050	COG2271	Major facilitator Superfamily
F8237_RS24055	COG2199	diguanylate cyclase activity
F8237_RS24055	COG2202	Pas domain
F8237_RS24055	COG2200	EAL domain
F8237_RS24065	COG2124	cytochrome p450
F8237_RS24100	COG3258	Cytochrome c
F8237_RS24145	COG1309	transcriptional regulator
F8237_RS24150	COG4297	protein containing double-stranded beta helix domain
F8237_RS24185	COG0114	fumarate hydratase activity
F8237_RS24225	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
F8237_RS24240	COG0330	HflC and HflK could
F8237_RS24245	COG0330	HflC and HflK could
F8237_RS24265	COG3830	Belongs to the UPF0237 family
F8237_RS24265	COG0560	Phosphoserine phosphatase
F8237_RS24270	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F8237_RS24275	COG0028	Belongs to the TPP enzyme family
F8237_RS24285	COG0440	acetolactate synthase activity
F8237_RS24295	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F8237_RS24300	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS24310	COG1174	glycine betaine transport
F8237_RS24315	COG0517	IMP dehydrogenase activity
F8237_RS24315	COG1125	glycine betaine transport
F8237_RS24325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F8237_RS24390	COG2326	polyphosphate kinase activity
F8237_RS24395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F8237_RS24400	COG0668	transmembrane transport
F8237_RS24410	COG0281	malic enzyme
F8237_RS24415	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F8237_RS24430	COG2072	flavoprotein involved in K transport
F8237_RS24450	COG3384	dioxygenase
F8237_RS24455	COG4095	Psort location CytoplasmicMembrane, score
F8237_RS24460	COG0297	glycogen (starch) synthase activity
F8237_RS24465	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F8237_RS24485	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F8237_RS24490	COG0673	inositol 2-dehydrogenase activity
F8237_RS24525	COG0559	Belongs to the binding-protein-dependent transport system permease family
F8237_RS24530	COG0683	leucine binding
F8237_RS24535	COG1181	Belongs to the D-alanine--D-alanine ligase family
F8237_RS24550	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F8237_RS24610	COG0181	hydroxymethylbilane synthase activity
F8237_RS24620	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
F8237_RS24625	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F8237_RS24640	COG1233	COG1233 Phytoene dehydrogenase and related
F8237_RS24645	COG1562	ergosterol biosynthetic process
F8237_RS24650	COG0408	coproporphyrinogen oxidase activity
F8237_RS24665	COG0142	geranyltranstransferase activity
F8237_RS24670	COG0500	methyltransferase
F8237_RS24675	COG1063	alcohol dehydrogenase
F8237_RS24680	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
F8237_RS24685	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
F8237_RS24690	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
F8237_RS24725	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
F8237_RS24730	COG2211	Major facilitator Superfamily
F8237_RS24735	COG0644	oxidoreductase
F8237_RS24740	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
F8237_RS24760	COG4251	negative regulation of phosphorylation
F8237_RS24765	COG5398	heme oxygenase
F8237_RS24780	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
F8237_RS24785	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
F8237_RS24795	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
F8237_RS24805	COG2814	Major facilitator Superfamily
F8237_RS24830	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
F8237_RS24840	COG0156	8-amino-7-oxononanoate synthase activity
F8237_RS24875	COG1960	acyl-CoA dehydrogenase activity
F8237_RS24885	COG1802	Transcriptional regulator
F8237_RS24890	COG4221	oxidoreductase activity
F8237_RS24895	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS24930	COG2079	MmgE PrpD family protein
F8237_RS24945	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F8237_RS24950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F8237_RS24955	COG1802	Transcriptional regulator
F8237_RS24975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F8237_RS24985	COG0179	Fumarylacetoacetate (FAA) hydrolase
F8237_RS24990	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F8237_RS25010	COG2169	Transcriptional regulator
F8237_RS25045	COG1764	response to oxidative stress
F8237_RS25050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F8237_RS25065	COG2223	nitrite transmembrane transporter activity
F8237_RS25090	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F8237_RS25105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F8237_RS25125	COG1228	amidohydrolase
F8237_RS25130	COG2986	histidine ammonia-lyase
F8237_RS25135	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
F8237_RS25225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F8237_RS25225	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
F8237_RS25230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F8237_RS25235	COG0277	FAD linked oxidase domain protein
F8237_RS25240	COG1250	3-hydroxyacyl-CoA dehydrogenase
F8237_RS25250	COG0723	plastoquinol--plastocyanin reductase activity
F8237_RS25280	COG3791	Glutathione-dependent formaldehyde-activating
F8237_RS25285	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
F8237_RS25355	COG1116	anion transmembrane transporter activity
F8237_RS25410	COG1131	(ABC) transporter
F8237_RS25430	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
F8237_RS25435	COG2197	response regulator
F8237_RS25440	COG4585	Histidine kinase
F8237_RS25445	COG4771	TonB-dependent receptor
F8237_RS25465	COG2723	6-phospho-beta-galactosidase activity
F8237_RS25470	COG0183	Belongs to the thiolase family
F8237_RS25475	COG0776	regulation of translation
F8237_RS25480	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F8237_RS25495	COG2095	MarC family integral membrane protein
F8237_RS25500	COG0235	Class ii aldolase
F8237_RS25565	COG1301	dicarboxylic acid transport
F8237_RS25570	COG0024	Methionine aminopeptidase
F8237_RS25645	COG2010	Cytochrome c
F8237_RS25665	COG5001	Diguanylate cyclase
F8237_RS25665	COG3300	MHYT domain
F8237_RS25675	COG0010	Belongs to the arginase family
F8237_RS25685	COG4948	Mandelate Racemase Muconate Lactonizing
F8237_RS25745	COG2204	response regulator
F8237_RS25985	COG2084	Dehydrogenase
F8237_RS25995	COG0129	dihydroxy-acid dehydratase activity
F8237_RS26005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F8237_RS26010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F8237_RS26020	COG1250	3-hydroxyacyl-CoA dehydrogenase
F8237_RS26030	COG0318	PFAM AMP-dependent synthetase and ligase
F8237_RS26045	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS26050	COG1024	Enoyl-CoA hydratase
F8237_RS26085	COG0251	oxidation-reduction process
F8237_RS26090	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
F8237_RS26090	COG0517	IMP dehydrogenase activity
F8237_RS26090	COG0617	tRNA 3'-terminal CCA addition
F8237_RS26095	COG3243	poly(R)-hydroxyalkanoic acid synthase
F8237_RS26140	COG1127	ABC transporter
F8237_RS26145	COG3218	ABC-type transport auxiliary lipoprotein component
F8237_RS26145	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F8237_RS26150	COG2010	Cytochrome c
F8237_RS26155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F8237_RS26165	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
F8237_RS26175	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F8237_RS26190	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS26200	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F8237_RS26200	COG2010	Cytochrome c
F8237_RS26205	COG2080	2 iron, 2 sulfur cluster binding
F8237_RS26210	COG3181	Tripartite tricarboxylate transporter family receptor
F8237_RS26215	COG0243	molybdopterin cofactor binding
F8237_RS26225	COG1024	Enoyl-CoA hydratase
F8237_RS26235	COG0247	lactate metabolic process
F8237_RS26235	COG0277	FAD linked oxidase domain protein
F8237_RS26240	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F8237_RS26245	COG1024	Enoyl-CoA hydratase
F8237_RS26250	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
F8237_RS26255	COG3181	Tripartite tricarboxylate transporter family receptor
F8237_RS26270	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
F8237_RS26275	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
F8237_RS26280	COG0463	Glycosyl transferase, family 2
F8237_RS26285	COG3958	Transketolase
F8237_RS26290	COG3959	Transketolase, thiamine diphosphate binding domain
F8237_RS26315	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F8237_RS26320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F8237_RS26345	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
F8237_RS26360	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F8237_RS26360	COG2755	lipolytic protein G-D-S-L family
F8237_RS26375	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F8237_RS26380	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F8237_RS26415	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F8237_RS26430	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F8237_RS26455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F8237_RS26465	COG2942	2-epimerase
F8237_RS26485	COG0559	Belongs to the binding-protein-dependent transport system permease family
F8237_RS26490	COG2852	Protein conserved in bacteria
F8237_RS26495	COG0318	PFAM AMP-dependent synthetase and ligase
F8237_RS26555	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F8237_RS26600	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F8237_RS26605	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
F8237_RS26610	COG2072	flavoprotein involved in K transport
F8237_RS26645	COG1132	(ABC) transporter
F8237_RS26675	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F8237_RS26690	COG0697	spore germination
F8237_RS26695	COG1522	sequence-specific DNA binding
F8237_RS26710	COG0583	DNA-binding transcription factor activity
F8237_RS26720	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
F8237_RS26725	COG0859	PFAM glycosyl transferase family 9
F8237_RS26735	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F8237_RS26735	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F8237_RS26760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F8237_RS26775	COG0662	Cupin 2, conserved barrel domain protein
F8237_RS26775	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
F8237_RS26780	COG0673	inositol 2-dehydrogenase activity
F8237_RS26795	COG0728	peptidoglycan biosynthetic process
F8237_RS26805	COG1063	alcohol dehydrogenase
F8237_RS26815	COG3909	cytochrome
F8237_RS26830	COG2010	Cytochrome c
F8237_RS26840	COG1215	transferase activity, transferring glycosyl groups
F8237_RS26860	COG0351	phosphomethylpyrimidine kinase
F8237_RS26870	COG0438	transferase activity, transferring glycosyl groups
F8237_RS26900	COG2814	Major facilitator Superfamily
F8237_RS26905	COG4948	Mandelate Racemase Muconate Lactonizing
F8237_RS26910	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F8237_RS26915	COG1127	ABC transporter
F8237_RS26920	COG3218	ABC-type transport auxiliary lipoprotein component
F8237_RS26920	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F8237_RS26940	COG0633	Ferredoxin
F8237_RS26950	COG0492	ferredoxin-NADP+ reductase activity
F8237_RS26980	COG2721	sulfolactate sulfo-lyase activity
F8237_RS26985	COG1012	belongs to the aldehyde dehydrogenase family
F8237_RS26990	COG4948	Mandelate Racemase Muconate Lactonizing
F8237_RS26995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F8237_RS27000	COG0583	DNA-binding transcription factor activity
F8237_RS27005	COG2271	Major facilitator Superfamily
F8237_RS27035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F8237_RS27060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F8237_RS27065	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F8237_RS27070	COG1749	Flagellar hook protein flgE
F8237_RS27100	COG0076	glutamate decarboxylase activity
F8237_RS27105	COG5443	negative regulation of bacterial-type flagellum assembly
F8237_RS27110	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F8237_RS27115	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F8237_RS27120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F8237_RS27125	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F8237_RS27155	COG1706	bacterial-type flagellum-dependent cell motility
F8237_RS27165	COG1733	regulation of RNA biosynthetic process
F8237_RS27170	COG2910	NAD(P)H-binding
F8237_RS27180	COG1733	regulation of RNA biosynthetic process
F8237_RS27185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F8237_RS27190	COG3971	2-oxopent-4-enoate hydratase activity
F8237_RS27195	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
F8237_RS27205	COG4786	Flagellar basal body rod
F8237_RS27210	COG4786	Flagellar basal body rod
F8237_RS27245	COG1338	Plays a role in the flagellum-specific transport system
F8237_RS27255	COG1815	bacterial-type flagellum-dependent cell motility
F8237_RS27260	COG1558	bacterial-type flagellum-dependent cell motility
F8237_RS27265	COG1677	Flagellar hook-basal body complex protein FliE
F8237_RS27270	COG1987	bacterial-type flagellum assembly
F8237_RS27275	COG1684	flagellar biosynthetic protein fliR
F8237_RS27315	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
F8237_RS27315	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
F8237_RS27335	COG2917	probably involved in intracellular septation
F8237_RS27425	COG0446	pyridine nucleotide-disulphide oxidoreductase
F8237_RS27430	COG0640	Transcriptional regulator
F8237_RS27520	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F8237_RS27540	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F8237_RS27540	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F8237_RS27545	COG0509	glycine decarboxylation via glycine cleavage system
F8237_RS27550	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F8237_RS27555	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F8237_RS27560	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F8237_RS27580	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
F8237_RS27595	COG0604	alcohol dehydrogenase
F8237_RS27600	COG2909	trisaccharide binding
F8237_RS27605	COG2020	methyltransferase activity
F8237_RS27630	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
F8237_RS27640	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F8237_RS27645	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F8237_RS27650	COG0047	phosphoribosylformylglycinamidine synthase activity
F8237_RS27655	COG3181	Tripartite tricarboxylate transporter family receptor
F8237_RS27670	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F8237_RS27700	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
F8237_RS27705	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F8237_RS27710	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
F8237_RS27715	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
F8237_RS27735	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F8237_RS27775	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F8237_RS27810	COG0583	DNA-binding transcription factor activity
F8237_RS27815	COG0318	PFAM AMP-dependent synthetase and ligase
F8237_RS27825	COG1473	amidohydrolase
F8237_RS27830	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F8237_RS27835	COG1309	transcriptional regulator
F8237_RS27870	COG2815	serine threonine protein kinase
F8237_RS27870	COG0515	serine threonine protein kinase
F8237_RS27925	COG0784	Response regulator, receiver
F8237_RS27925	COG4191	Histidine kinase
F8237_RS27970	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F8237_RS27975	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F8237_RS27980	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F8237_RS28015	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
F8237_RS28015	COG3608	succinylglutamate desuccinylase aspartoacylase
F8237_RS28055	COG0640	Transcriptional regulator
F8237_RS28060	COG1309	transcriptional regulator
F8237_RS28070	COG1131	(ABC) transporter
F8237_RS28075	COG0842	Transport permease protein
F8237_RS28085	COG0384	phenazine biosynthesis protein PhzF
F8237_RS28135	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS28160	COG0681	Belongs to the peptidase S26 family
F8237_RS28165	COG0459	protein refolding
F8237_RS28170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F8237_RS28175	COG5425	PFAM Usg family protein
F8237_RS28195	COG4221	oxidoreductase activity
F8237_RS28220	COG2308	Evidence 4 Homologs of previously reported genes of
F8237_RS28225	COG1546	Belongs to the CinA family
F8237_RS28225	COG1058	Belongs to the CinA family
F8237_RS28230	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
F8237_RS28245	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F8237_RS28250	COG0625	glutathione transferase activity
F8237_RS28260	COG3321	synthase
F8237_RS28260	COG0604	alcohol dehydrogenase
F8237_RS28265	COG1024	Enoyl-CoA hydratase
F8237_RS28270	COG0154	amidase activity
F8237_RS28275	COG1473	amidohydrolase
F8237_RS28290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F8237_RS28295	COG0601	transmembrane transport
F8237_RS28310	COG0747	negative chemotaxis
F8237_RS28315	COG0747	negative chemotaxis
F8237_RS28325	COG2814	Major facilitator Superfamily
F8237_RS28335	COG1024	Enoyl-CoA hydratase
F8237_RS28360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F8237_RS28375	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F8237_RS28455	COG3833	ABC-type maltose transport systems, permease component
F8237_RS28460	COG1176	ABC-type spermidine putrescine transport system, permease component I
F8237_RS28470	COG3842	ATPase activity
F8237_RS28505	COG1063	alcohol dehydrogenase
F8237_RS28515	COG0346	lactoylglutathione lyase activity
F8237_RS28520	COG0513	Belongs to the DEAD box helicase family
F8237_RS28550	COG0517	IMP dehydrogenase activity
F8237_RS28555	COG1752	Esterase of the alpha-beta hydrolase superfamily
F8237_RS28585	COG4221	oxidoreductase activity
F8237_RS28585	COG3321	synthase
F8237_RS28585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F8237_RS28585	COG0604	alcohol dehydrogenase
F8237_RS28605	COG5001	Diguanylate cyclase
F8237_RS28630	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F8237_RS28635	COG2814	Major facilitator Superfamily
F8237_RS28655	COG0531	amino acid
F8237_RS28670	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F8237_RS28685	COG0302	gtp cyclohydrolase
F8237_RS28690	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F8237_RS28720	COG3655	Transcriptional regulator
F8237_RS28730	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F8237_RS28785	COG0840	transmembrane signaling receptor activity
F8237_RS28820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F8237_RS28830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8237_RS28840	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
F8237_RS28850	COG0210	DNA helicase
F8237_RS28860	COG3795	YCII-related domain
F8237_RS28920	COG1450	Type ii and iii secretion system protein
F8237_RS28925	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F8237_RS28930	COG1459	type II secretion system
F8237_RS28940	COG4969	Belongs to the N-Me-Phe pilin family
F8237_RS29000	COG0297	glycogen (starch) synthase activity
F8237_RS29005	COG0297	glycogen (starch) synthase activity
F8237_RS29010	COG0367	asparagine synthase
F8237_RS29030	COG1696	Membrane protein involved in D-alanine export
F8237_RS29040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F8237_RS29045	COG2192	nodulation
F8237_RS29055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F8237_RS29110	COG2831	hemolysin activation secretion protein
F8237_RS29115	COG0811	peptide transport
F8237_RS29140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F8237_RS29145	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F8237_RS29155	COG0489	protein tyrosine kinase activity
F8237_RS29155	COG3206	protein involved in exopolysaccharide biosynthesis
F8237_RS29185	COG3246	L-lysine catabolic process to acetate
F8237_RS29210	COG1960	acyl-CoA dehydrogenase activity
F8237_RS29245	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS29250	COG0406	alpha-ribazole phosphatase activity
F8237_RS29255	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS29270	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F8237_RS29275	COG0250	Participates in transcription elongation, termination and antitermination
F8237_RS29280	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F8237_RS29285	COG0081	regulation of translation
F8237_RS29290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F8237_RS29295	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F8237_RS29300	COG0222	ribosome binding
F8237_RS29305	COG0085	RNA polymerase activity
F8237_RS29310	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F8237_RS29315	COG1231	oxidoreductase activity
F8237_RS29320	COG1132	(ABC) transporter
F8237_RS29330	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F8237_RS29335	COG0049	tRNA binding
F8237_RS29340	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F8237_RS29345	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F8237_RS29350	COG0051	transcription antitermination factor activity, RNA binding
F8237_RS29355	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F8237_RS29360	COG0088	Forms part of the polypeptide exit tunnel
F8237_RS29365	COG0089	rRNA binding
F8237_RS29370	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F8237_RS29375	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F8237_RS29380	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F8237_RS29385	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F8237_RS29390	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F8237_RS29395	COG0255	Belongs to the universal ribosomal protein uL29 family
F8237_RS29400	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F8237_RS29405	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F8237_RS29410	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F8237_RS29415	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F8237_RS29420	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F8237_RS29425	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F8237_RS29430	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F8237_RS29435	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F8237_RS29440	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F8237_RS29445	COG1841	ribosomal large subunit assembly
F8237_RS29450	COG0200	Binds to the 23S rRNA
F8237_RS29460	COG0563	adenylate kinase activity
F8237_RS29465	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F8237_RS29470	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F8237_RS29475	COG0202	RNA polymerase activity
F8237_RS29480	COG0203	ribosomal protein L17
F8237_RS29485	COG2010	Cytochrome c
F8237_RS29490	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS29500	COG1733	regulation of RNA biosynthetic process
F8237_RS29515	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F8237_RS29545	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F8237_RS29570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F8237_RS29630	COG2860	membrane
F8237_RS29660	COG2030	dehydratase
F8237_RS29665	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS29680	COG0697	spore germination
F8237_RS29765	COG0415	Belongs to the DNA photolyase family
F8237_RS29770	COG0450	alkyl hydroperoxide reductase
F8237_RS29790	COG2197	response regulator
F8237_RS29795	COG0577	efflux transmembrane transporter activity
F8237_RS29795	COG1136	(ABC) transporter
F8237_RS29800	COG0577	efflux transmembrane transporter activity
F8237_RS29800	COG1136	(ABC) transporter
F8237_RS29805	COG1566	PFAM secretion protein HlyD family protein
F8237_RS29810	COG4566	intracellular signal transduction
F8237_RS29850	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS29880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F8237_RS29900	COG0179	Fumarylacetoacetate (FAA) hydrolase
F8237_RS29905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F8237_RS29910	COG1414	Transcriptional regulator
F8237_RS29920	COG2197	response regulator
F8237_RS29925	COG3851	Histidine kinase
F8237_RS29935	COG1063	alcohol dehydrogenase
F8237_RS29940	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS29945	COG4948	Mandelate Racemase Muconate Lactonizing
F8237_RS29955	COG2271	Major facilitator Superfamily
F8237_RS29965	COG0745	RESPONSE REGULATOR receiver
F8237_RS29970	COG4191	Histidine kinase
F8237_RS29980	COG4191	Histidine kinase
F8237_RS29980	COG0784	Response regulator, receiver
F8237_RS29990	COG4770	biotin carboxylase activity
F8237_RS29995	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
F8237_RS30000	COG1254	Belongs to the acylphosphatase family
F8237_RS30025	COG0321	lipoyl(octanoyl) transferase activity
F8237_RS30040	COG4977	sequence-specific DNA binding
F8237_RS30075	COG2239	Acts as a magnesium transporter
F8237_RS30085	COG0656	L-ascorbic acid biosynthetic process
F8237_RS30120	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F8237_RS30125	COG1192	Involved in chromosome partitioning
F8237_RS30150	COG1686	Belongs to the peptidase S11 family
F8237_RS30160	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
F8237_RS30175	COG2814	Major facilitator Superfamily
F8237_RS30220	COG1720	tRNA m6t6A37 methyltransferase activity
F8237_RS30235	COG0537	adenosine 5'-monophosphoramidase activity
F8237_RS30265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F8237_RS30275	COG0784	Response regulator, receiver
F8237_RS30300	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F8237_RS30305	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F8237_RS30330	COG0557	exoribonuclease II activity
F8237_RS30335	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F8237_RS30345	COG2827	Endonuclease containing a URI domain
F8237_RS30355	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS30365	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
F8237_RS30370	COG1733	regulation of RNA biosynthetic process
F8237_RS30375	COG0758	DNA mediated transformation
F8237_RS30380	COG0154	amidase activity
F8237_RS30390	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
F8237_RS30395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F8237_RS30400	COG0540	Belongs to the ATCase OTCase family
F8237_RS30410	COG1960	acyl-CoA dehydrogenase activity
F8237_RS30425	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F8237_RS30435	COG0583	DNA-binding transcription factor activity
F8237_RS30445	COG2070	2-Nitropropane dioxygenase
F8237_RS30450	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F8237_RS30460	COG0154	amidase activity
F8237_RS30470	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F8237_RS30500	COG0741	lytic transglycosylase activity
F8237_RS30505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F8237_RS30510	COG1970	mechanosensitive ion channel activity
F8237_RS30515	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F8237_RS30535	COG1758	RNA polymerase activity
F8237_RS30545	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
F8237_RS30550	COG0736	holo-[acyl-carrier-protein] synthase activity
F8237_RS30555	COG0681	Belongs to the peptidase S26 family
F8237_RS30560	COG0571	ribonuclease III activity
F8237_RS30565	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F8237_RS30575	COG1381	Involved in DNA repair and RecF pathway recombination
F8237_RS30585	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F8237_RS30625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F8237_RS30650	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
F8237_RS30670	COG1914	H( )-stimulated, divalent metal cation uptake system
F8237_RS30675	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
F8237_RS30685	COG0113	porphobilinogen synthase activity
F8237_RS30710	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F8237_RS30715	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F8237_RS30720	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F8237_RS30720	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F8237_RS30730	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F8237_RS30735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F8237_RS30740	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
F8237_RS30755	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
F8237_RS30785	COG0416	fatty acid biosynthetic process
F8237_RS30790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F8237_RS30795	COG0776	regulation of translation
F8237_RS30820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F8237_RS30870	COG3268	Saccharopine dehydrogenase
F8237_RS30875	COG3268	Saccharopine dehydrogenase
F8237_RS30890	COG0438	transferase activity, transferring glycosyl groups
F8237_RS30915	COG1612	heme a metabolic process
F8237_RS30935	COG1024	Enoyl-CoA hydratase
F8237_RS30945	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F8237_RS30950	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F8237_RS30980	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F8237_RS31000	COG1942	4-Oxalocrotonate Tautomerase
F8237_RS31005	COG0174	glutamine synthetase
F8237_RS31010	COG0347	Belongs to the P(II) protein family
F8237_RS31015	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
F8237_RS31015	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F8237_RS31025	COG2132	Multicopper oxidase
F8237_RS31035	COG0544	peptidyl-prolyl cis-trans isomerase activity
F8237_RS31040	COG0740	serine-type endopeptidase activity
F8237_RS31045	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F8237_RS31050	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F8237_RS31065	COG2226	methyltransferase
F8237_RS31070	COG1230	cation diffusion facilitator family transporter
F8237_RS31100	COG2195	Cleaves the N-terminal amino acid of tripeptides
F8237_RS31105	COG0776	regulation of translation
F8237_RS31120	COG2814	Major facilitator Superfamily
F8237_RS31135	COG4774	siderophore transport
F8237_RS31145	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F8237_RS31155	COG0649	NAD binding
F8237_RS31165	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
F8237_RS31175	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
F8237_RS31185	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F8237_RS31190	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F8237_RS31200	COG0713	ATP synthesis coupled electron transport
F8237_RS31215	COG1007	ATP synthesis coupled electron transport
F8237_RS31220	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
F8237_RS31220	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
F8237_RS31230	COG0346	lactoylglutathione lyase activity
F8237_RS31255	COG0747	negative chemotaxis
F8237_RS31260	COG0601	transmembrane transport
F8237_RS31265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F8237_RS31270	COG0444	Belongs to the ABC transporter superfamily
F8237_RS31275	COG4608	Belongs to the ABC transporter superfamily
F8237_RS31285	COG1172	Belongs to the binding-protein-dependent transport system permease family
F8237_RS31290	COG1129	ABC transporter
F8237_RS31310	COG4774	siderophore transport
F8237_RS31310	COG4774	siderophore transport
F8237_RS31320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F8237_RS31345	COG0442	prolyl-tRNA aminoacylation
F8237_RS31355	COG1136	(ABC) transporter
F8237_RS31385	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F8237_RS31405	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F8237_RS31415	COG2814	Major facilitator Superfamily
F8237_RS31445	COG0052	Belongs to the universal ribosomal protein uS2 family
F8237_RS31450	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F8237_RS31455	COG0528	UMP kinase activity
F8237_RS31460	COG0233	cytoplasmic translational termination
F8237_RS31465	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F8237_RS31475	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F8237_RS31480	COG0750	zinc metalloprotease
F8237_RS31485	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F8237_RS31490	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F8237_RS31495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F8237_RS31505	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F8237_RS31510	COG3494	Protein of unknown function (DUF1009)
F8237_RS31515	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F8237_RS31520	COG0372	Belongs to the citrate synthase family
F8237_RS31525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F8237_RS31530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F8237_RS31565	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F8237_RS31570	COG0303	'Molybdopterin
F8237_RS31580	COG1011	Hydrolase
F8237_RS31585	COG1304	FMN binding
F8237_RS31590	COG0793	Belongs to the peptidase S41A family
F8237_RS31595	COG5001	Diguanylate cyclase
F8237_RS31595	COG3300	MHYT domain
F8237_RS31600	COG0315	cyclic pyranopterin monophosphate synthase activity
F8237_RS31605	COG0134	indole-3-glycerol-phosphate synthase activity
F8237_RS31610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F8237_RS31615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F8237_RS31620	COG0149	triose-phosphate isomerase activity
F8237_RS31630	COG0504	CTP synthase activity
F8237_RS31635	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F8237_RS31640	COG2205	protein histidine kinase activity
F8237_RS31645	COG0745	RESPONSE REGULATOR receiver
F8237_RS31660	COG2877	3-deoxy-8-phosphooctulonate synthase activity
F8237_RS31685	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F8237_RS31690	COG3842	ATPase activity
F8237_RS31700	COG1840	ABC-type Fe3 transport system, periplasmic component
F8237_RS31710	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F8237_RS31715	COG0148	phosphopyruvate hydratase activity
F8237_RS31720	COG1063	alcohol dehydrogenase
F8237_RS31730	COG0431	NADPH-dependent FMN reductase
F8237_RS31740	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F8237_RS31745	COG0022	dehydrogenase e1 component
F8237_RS31745	COG0508	dehydrogenase complex catalyzes the overall conversion of
F8237_RS31760	COG0508	dehydrogenase complex catalyzes the overall conversion of
F8237_RS31765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F8237_RS31770	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F8237_RS31780	COG0741	lytic transglycosylase activity
F8237_RS31805	COG4206	TonB-dependent receptor
F8237_RS31830	COG0789	Transcriptional regulator
F8237_RS31835	COG0129	dihydroxy-acid dehydratase activity
F8237_RS31840	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
F8237_RS31845	COG0708	Exodeoxyribonuclease III
F8237_RS31850	COG2198	Histidine kinase
F8237_RS31850	COG0784	Response regulator, receiver
F8237_RS31850	COG5002	protein histidine kinase activity
F8237_RS31865	COG0232	Belongs to the dGTPase family. Type 2 subfamily
F8237_RS31870	COG0018	arginyl-trna synthetase
F8237_RS31880	COG1472	Belongs to the glycosyl hydrolase 3 family
F8237_RS31885	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
F8237_RS31890	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F8237_RS31895	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F8237_RS31900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F8237_RS31905	COG0805	protein transport
F8237_RS31910	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F8237_RS31920	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
F8237_RS31930	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F8237_RS31945	COG1862	Preprotein translocase
F8237_RS31950	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F8237_RS31970	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F8237_RS31980	COG2340	Cysteine-rich secretory protein family
F8237_RS31990	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
F8237_RS32075	COG0546	phosphoglycolate phosphatase activity
F8237_RS32090	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F8237_RS32110	COG0629	single-stranded DNA binding
F8237_RS32115	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F8237_RS32120	COG3158	transport of potassium into the cell
F8237_RS32130	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F8237_RS32150	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F8237_RS32155	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F8237_RS32165	COG1309	transcriptional regulator
F8237_RS32175	COG0343	queuine tRNA-ribosyltransferase activity
F8237_RS32220	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F8237_RS32240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F8237_RS32245	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
F8237_RS32260	COG0628	permease
F8237_RS32335	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F8237_RS32345	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F8237_RS32360	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F8237_RS32375	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F8237_RS32380	COG1278	Cold shock
F8237_RS32415	COG0679	Auxin Efflux Carrier
F8237_RS32420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F8237_RS32425	COG1183	phosphatidylcholine synthase activity
F8237_RS32430	COG1253	flavin adenine dinucleotide binding
F8237_RS32440	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F8237_RS32455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F8237_RS32460	COG3707	response regulator
F8237_RS32465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F8237_RS32470	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F8237_RS32475	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F8237_RS32485	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F8237_RS32490	COG1984	allophanate hydrolase subunit 2
F8237_RS32500	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F8237_RS32500	COG0473	3-isopropylmalate dehydrogenase activity
F8237_RS32520	COG2031	fatty acid transporter
F8237_RS32555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F8237_RS32565	COG0395	ABC-type sugar transport system, permease component
F8237_RS32570	COG1175	transmembrane transport
F8237_RS32600	COG1335	isochorismatase
F8237_RS32610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F8237_RS32610	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F8237_RS32625	COG0444	Belongs to the ABC transporter superfamily
F8237_RS32635	COG0601	transmembrane transport
F8237_RS32640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F8237_RS32645	COG0129	dihydroxy-acid dehydratase activity
F8237_RS32695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F8237_RS32800	COG0348	domain, Protein
F8237_RS32880	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F8237_RS32910	COG2267	carboxylic ester hydrolase activity
F8237_RS32915	COG1686	Belongs to the peptidase S11 family
F8237_RS32920	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F8237_RS32935	COG0084	hydrolase, TatD family'
F8237_RS32940	COG0321	lipoyl(octanoyl) transferase activity
F8237_RS32940	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
F8237_RS32950	COG0318	PFAM AMP-dependent synthetase and ligase
F8237_RS32960	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F8237_RS33075	COG1256	bacterial-type flagellum assembly
F8237_RS33095	COG1230	cation diffusion facilitator family transporter
F8237_RS33165	COG4786	Flagellar basal body rod
F8237_RS33220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F8237_RS33275	COG4263	nitrous-oxide reductase activity
F8237_RS33305	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F8237_RS33305	COG0574	Belongs to the PEP-utilizing enzyme family
F8237_RS33325	COG1408	metallophosphoesterase
F8237_RS33350	COG0628	permease
F8237_RS33360	COG1053	succinate dehydrogenase
F8237_RS33370	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F8237_RS33375	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
F8237_RS33380	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
F8237_RS33385	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F8237_RS33415	COG4774	siderophore transport
F8237_RS33425	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
F8237_RS33425	COG0517	IMP dehydrogenase activity
F8237_RS33425	COG0617	tRNA 3'-terminal CCA addition
F8237_RS33455	COG1464	Belongs to the NlpA lipoprotein family
F8237_RS33460	COG2011	ABC-type metal ion transport system permease component
F8237_RS33465	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F8237_RS33485	COG1024	Enoyl-CoA hydratase
F8237_RS33510	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
F8237_RS33515	COG3956	TIGRFAM MazG family protein
F8237_RS33520	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F8237_RS33525	COG1923	regulation of RNA biosynthetic process
F8237_RS33530	COG2204	response regulator
F8237_RS33535	COG5000	phosphorelay sensor kinase activity
F8237_RS33560	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F8237_RS33560	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F8237_RS33565	COG1058	Belongs to the CinA family
F8237_RS33565	COG1546	Belongs to the CinA family
F8237_RS33590	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F8237_RS33595	COG2863	cytochrome
F8237_RS33600	COG2867	negative regulation of translational initiation
F8237_RS33605	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F8237_RS33610	COG2094	Belongs to the DNA glycosylase MPG family
F8237_RS33615	COG0525	valine-tRNA ligase activity
F8237_RS33630	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F8237_RS33675	COG2226	methyltransferase
F8237_RS33700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F8237_RS33720	COG1126	abc transporter atp-binding protein
F8237_RS33725	COG0765	amino acid transport
F8237_RS33730	COG4597	amino acid ABC transporter
F8237_RS33735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8237_RS33740	COG0626	cystathionine gamma-synthase activity
F8237_RS33745	COG1283	sodium-dependent phosphate transmembrane transporter activity
F8237_RS33755	COG0463	Glycosyl transferase, family 2
F8237_RS33760	COG0671	phosphoesterase, PA-phosphatase related
F8237_RS33770	COG4953	penicillin-binding protein 1C
F8237_RS33775	COG2373	Large extracellular alpha-helical protein
F8237_RS33840	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F8237_RS33860	COG4770	biotin carboxylase activity
F8237_RS33865	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F8237_RS33870	COG1960	acyl-CoA dehydrogenase activity
F8237_RS33885	COG1522	sequence-specific DNA binding
F8237_RS33940	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F8237_RS33965	COG0776	regulation of translation
F8237_RS34030	COG0625	glutathione transferase activity
F8237_RS34085	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F8237_RS34105	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F8237_RS34115	COG2354	Protein conserved in bacteria
F8237_RS34125	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F8237_RS34160	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F8237_RS34165	COG0840	transmembrane signaling receptor activity
F8237_RS34170	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
F8237_RS34190	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F8237_RS34195	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
F8237_RS34200	COG1802	Transcriptional regulator
F8237_RS34225	COG1494	fructose-1,6-bisphosphatase
F8237_RS34235	COG0436	Aminotransferase
F8237_RS34245	COG3243	poly(R)-hydroxyalkanoic acid synthase
F8237_RS34255	COG4106	trans-aconitate 2-methyltransferase activity
F8237_RS34260	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F8237_RS34275	COG0586	Pfam SNARE associated Golgi protein
F8237_RS34280	COG0187	DNA topoisomerase II activity
F8237_RS34295	COG1028	Short-chain dehydrogenase reductase Sdr
F8237_RS34325	COG0513	Belongs to the DEAD box helicase family
F8237_RS34335	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F8237_RS34345	COG0316	Belongs to the HesB IscA family
F8237_RS34385	COG0640	Transcriptional regulator
F8237_RS34430	COG3258	Cytochrome c
F8237_RS34470	COG1742	UPF0060 membrane protein
F8237_RS34485	COG1695	Transcriptional regulator
F8237_RS34495	COG0737	Belongs to the 5'-nucleotidase family
F8237_RS34500	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F8237_RS34505	COG0477	Major facilitator Superfamily
F8237_RS34510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F8237_RS34510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F8237_RS34520	COG0813	purine-nucleoside phosphorylase activity
F8237_RS34540	COG1937	Protein conserved in bacteria
F8237_RS34580	COG2372	response to copper ion
F8237_RS34585	COG1276	copper resistance
F8237_RS34610	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F8237_RS34620	COG1595	DNA-templated transcription, initiation
F8237_RS34650	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
F8237_RS34655	COG2948	multi-organism process
F8237_RS34660	COG3504	Conjugal transfer protein
F8237_RS34670	COG3704	protein secretion by the type IV secretion system
F8237_RS34695	COG3451	type IV secretory pathway VirB4
F8237_RS34875	COG1475	DNA binding
F8237_RS34900	COG4227	nucleotidyltransferase activity
F8237_RS34960	COG5489	Protein of unknown function (DUF736)
F8237_RS34965	COG5489	Protein of unknown function (DUF736)
F8237_RS35060	COG1192	Involved in chromosome partitioning
F8237_RS35065	COG1475	DNA binding
F8237_RS35070	COG1414	Transcriptional regulator
F8237_RS35080	COG0629	single-stranded DNA binding
F8237_RS35095	COG1414	Transcriptional regulator
F8237_RS35105	COG1192	Involved in chromosome partitioning
F8237_RS35120	COG2197	response regulator
F8237_RS35135	COG0183	Belongs to the thiolase family
F8237_RS35145	COG4372	Transposase
F8237_RS35170	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
F8237_RS35180	COG4584	PFAM Integrase catalytic
F8237_RS35185	COG3547	Transposase (IS116 IS110 IS902 family)
F8237_RS35210	COG3485	protocatechuate 3,4-dioxygenase
F8237_RS35215	COG3485	protocatechuate 3,4-dioxygenase
F8237_RS35220	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F8237_RS35250	COG4774	siderophore transport
F8237_RS35310	COG0542	response to heat
F8237_RS35320	COG3608	succinylglutamate desuccinylase aspartoacylase
F8237_RS35320	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
F8237_RS35410	COG4232	protein-disulfide reductase activity
F8237_RS35420	COG1388	LysM domain
F8237_RS35420	COG1376	ErfK ybiS ycfS ynhG family protein
F8237_RS35440	COG0737	Belongs to the 5'-nucleotidase family
F8237_RS35445	COG2863	cytochrome
F8237_RS35450	COG3258	Cytochrome c
F8237_RS35460	COG2855	membrane
F8237_RS35525	COG1234	tRNA 3'-trailer cleavage
F8237_RS35530	COG0813	purine-nucleoside phosphorylase activity
F8237_RS35545	COG0642	Histidine kinase
F8237_RS35580	COG0671	phosphoesterase, PA-phosphatase related
F8237_RS35595	COG0588	phosphoglycerate mutase activity
F8237_RS35600	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F8237_RS35665	COG0671	phosphoesterase, PA-phosphatase related
F8237_RS35670	COG0642	Histidine kinase
F8237_RS35675	COG0642	Histidine kinase
F8237_RS35695	COG3038	cytochrome b561
F8237_RS35705	COG1937	Protein conserved in bacteria
F8237_RS35710	COG2132	Multicopper oxidase
F8237_RS35715	COG0640	Transcriptional regulator
F8237_RS35720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F8237_RS35750	COG0737	Belongs to the 5'-nucleotidase family
F8237_RS35760	COG3258	Cytochrome c
F8237_RS35815	COG1695	Transcriptional regulator
F8237_RS35830	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups