locus-tag	class	description
S23_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
S23_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
S23_RS00045	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S23_RS00050	COG0534	Mate efflux family protein
S23_RS00085	COG1741	Belongs to the pirin family
S23_RS00090	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
S23_RS00100	COG1879	ABC-type sugar transport system periplasmic component
S23_RS00105	COG5002	protein histidine kinase activity
S23_RS00105	COG0784	Response regulator, receiver
S23_RS00105	COG2198	Histidine kinase
S23_RS00125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S23_RS00135	COG0180	Tryptophanyl-tRNA synthetase
S23_RS00150	COG1214	PFAM Peptidase M22, glycoprotease
S23_RS00165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S23_RS00170	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S23_RS00175	COG1702	phosphate starvation-inducible protein PhoH
S23_RS00180	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
S23_RS00185	COG1253	flavin adenine dinucleotide binding
S23_RS00190	COG0815	Transfers the fatty acyl group on membrane lipoproteins
S23_RS00195	COG1396	sequence-specific DNA binding
S23_RS00205	COG0220	tRNA (guanine-N7-)-methyltransferase activity
S23_RS00215	COG0779	Required for maturation of 30S ribosomal subunits
S23_RS00230	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
S23_RS00235	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
S23_RS00240	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
S23_RS00245	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
S23_RS00250	COG1185	polyribonucleotide nucleotidyltransferase activity
S23_RS00260	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
S23_RS00280	COG0625	glutathione transferase activity
S23_RS00290	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
S23_RS00300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S23_RS00320	COG0583	DNA-binding transcription factor activity
S23_RS00325	COG0667	Aldo Keto reductase
S23_RS00355	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
S23_RS00360	COG2226	methyltransferase
S23_RS00365	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
S23_RS00375	COG0756	dUTP diphosphatase activity
S23_RS00380	COG2205	protein histidine kinase activity
S23_RS00385	COG3178	'Phosphotransferase
S23_RS00395	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
S23_RS00415	COG1793	dna ligase
S23_RS00430	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
S23_RS00435	COG0159	tryptophan synthase activity
S23_RS00440	COG0133	tryptophan synthase activity
S23_RS00445	COG0135	phosphoribosylanthranilate isomerase activity
S23_RS00455	COG0776	regulation of translation
S23_RS00460	COG0616	signal peptide processing
S23_RS00465	COG0539	negative regulation of cytoplasmic translation
S23_RS00470	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
S23_RS00475	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
S23_RS00495	COG1846	Transcriptional regulator
S23_RS00500	COG1764	response to oxidative stress
S23_RS00520	COG0395	ABC-type sugar transport system, permease component
S23_RS00525	COG3842	ATPase activity
S23_RS00530	COG0071	Belongs to the small heat shock protein (HSP20) family
S23_RS00540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S23_RS00545	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
S23_RS00550	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
S23_RS00555	COG1137	ATPase activity
S23_RS00560	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
S23_RS00575	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
S23_RS00585	COG2814	Major facilitator Superfamily
S23_RS00610	COG0277	FAD linked oxidase domain protein
S23_RS00615	COG1968	undecaprenyl-diphosphatase activity
S23_RS00625	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
S23_RS00645	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
S23_RS00655	COG0291	Belongs to the bacterial ribosomal protein bL35 family
S23_RS00660	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
S23_RS00670	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
S23_RS00675	COG0072	phenylalanine-tRNA ligase activity
S23_RS00675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S23_RS00695	COG1937	Protein conserved in bacteria
S23_RS00705	COG0864	Transcriptional regulator
S23_RS00725	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
S23_RS00735	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S23_RS00740	COG0588	phosphoglycerate mutase activity
S23_RS00745	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
S23_RS00755	COG0284	orotidine-5'-phosphate decarboxylase activity
S23_RS00765	COG3963	phosphatidate phosphatase activity
S23_RS00770	COG0484	heat shock protein binding
S23_RS00780	COG0443	Heat shock 70 kDa protein
S23_RS00790	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
S23_RS00795	COG1420	regulation of RNA biosynthetic process
S23_RS00800	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
S23_RS00805	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
S23_RS00810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S23_RS00825	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
S23_RS00830	COG0792	nuclease activity
S23_RS00835	COG0189	ligase activity
S23_RS00845	COG4964	Belongs to the GSP D family
S23_RS00880	COG5002	protein histidine kinase activity
S23_RS00880	COG0784	Response regulator, receiver
S23_RS00880	COG2205	protein histidine kinase activity
S23_RS00885	COG1072	(Pantothenic acid kinase))
S23_RS00890	COG0140	phosphoribosyl-ATP diphosphatase activity
S23_RS00895	COG0107	imidazoleglycerol-phosphate synthase activity
S23_RS00900	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
S23_RS00905	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
S23_RS00915	COG0131	Imidazoleglycerol-phosphate dehydratase
S23_RS00920	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
S23_RS00930	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
S23_RS00945	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
S23_RS00955	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
S23_RS00960	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
S23_RS00965	COG0237	dephospho-CoA kinase activity
S23_RS00970	COG0424	maF-like protein
S23_RS00975	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
S23_RS00980	COG1981	membrane
S23_RS00985	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
S23_RS00990	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
S23_RS00995	COG0445	tRNA wobble uridine modification
S23_RS01000	COG0357	Ribosomal RNA small subunit methyltransferase G
S23_RS01025	COG0495	leucyl-tRNA aminoacylation
S23_RS01030	COG3706	GGDEF domain
S23_RS01035	COG5001	Diguanylate cyclase
S23_RS01035	COG2203	Gaf domain
S23_RS01035	COG4251	negative regulation of phosphorylation
S23_RS01035	COG3706	GGDEF domain
S23_RS01055	COG0745	RESPONSE REGULATOR receiver
S23_RS01070	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
S23_RS01075	COG1674	ftsk spoiiie
S23_RS01080	COG0436	Aminotransferase
S23_RS01090	COG0004	ammonium transporteR
S23_RS01095	COG0347	Belongs to the P(II) protein family
S23_RS01100	COG0740	serine-type endopeptidase activity
S23_RS01110	COG0640	Transcriptional regulator
S23_RS01115	COG0004	ammonium transporteR
S23_RS01120	COG0347	Belongs to the P(II) protein family
S23_RS01130	COG1946	Acyl-CoA thioesterase
S23_RS01135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S23_RS01140	COG2835	tetraacyldisaccharide 4'-kinase activity
S23_RS01165	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
S23_RS01170	COG3118	belongs to the thioredoxin family
S23_RS01195	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S23_RS01205	COG0534	Mate efflux family protein
S23_RS01220	COG2814	Major facilitator Superfamily
S23_RS01225	COG0405	Gamma-glutamyltransferase
S23_RS01235	COG0138	bifunctional purine biosynthesis protein purh
S23_RS01260	COG1376	ErfK ybiS ycfS ynhG family protein
S23_RS01265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S23_RS01280	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
S23_RS01285	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
S23_RS01335	COG2814	Major facilitator Superfamily
S23_RS01360	COG4221	oxidoreductase activity
S23_RS01365	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
S23_RS01370	COG1024	Enoyl-CoA hydratase
S23_RS01385	COG1872	DUF167
S23_RS01390	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
S23_RS01395	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
S23_RS01400	COG1247	-acetyltransferase
S23_RS01410	COG3011	Protein conserved in bacteria
S23_RS01425	COG1217	gtp-binding protein TYPA
S23_RS01445	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
S23_RS01455	COG0784	Response regulator, receiver
S23_RS01470	COG2154	pterin-4-alpha-carbinolamine dehydratase
S23_RS01490	COG0604	alcohol dehydrogenase
S23_RS01490	COG3321	synthase
S23_RS01490	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS01495	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS01505	COG0820	rRNA (adenine-C2-)-methyltransferase activity
S23_RS01515	COG0671	phosphoesterase, PA-phosphatase related
S23_RS01520	COG0137	argininosuccinate synthase activity
S23_RS01525	COG1785	Belongs to the alkaline phosphatase family
S23_RS01565	COG4178	(ABC) transporter
S23_RS01570	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
S23_RS01600	COG0730	response to heat
S23_RS01605	COG0318	PFAM AMP-dependent synthetase and ligase
S23_RS01610	COG4221	oxidoreductase activity
S23_RS01615	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
S23_RS01620	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
S23_RS01625	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
S23_RS01635	COG0473	3-isopropylmalate dehydrogenase activity
S23_RS01655	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
S23_RS01660	COG0288	reversible hydration of carbon dioxide
S23_RS01665	COG2301	Belongs to the HpcH HpaI aldolase family
S23_RS01670	COG0546	phosphoglycolate phosphatase activity
S23_RS01695	COG0066	3-isopropylmalate dehydratase activity
S23_RS01730	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
S23_RS01735	COG0335	large ribosomal subunit rRNA binding
S23_RS01740	COG0336	Belongs to the RNA methyltransferase TrmD family
S23_RS01745	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
S23_RS01750	COG0228	four-way junction DNA binding
S23_RS01755	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
S23_RS01775	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
S23_RS01780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S23_RS01790	COG0564	pseudouridine synthase activity
S23_RS01795	COG0552	protein localization to endoplasmic reticulum
S23_RS01800	COG2917	probably involved in intracellular septation
S23_RS01805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S23_RS01815	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
S23_RS01820	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
S23_RS01825	COG4133	protoheme IX ABC transporter activity
S23_RS01830	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
S23_RS01855	COG0670	Belongs to the BI1 family
S23_RS01860	COG1136	(ABC) transporter
S23_RS01860	COG0577	efflux transmembrane transporter activity
S23_RS01865	COG1136	(ABC) transporter
S23_RS01870	COG2755	lipolytic protein G-D-S-L family
S23_RS01875	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
S23_RS01880	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
S23_RS01885	COG0039	L-malate dehydrogenase activity
S23_RS01890	COG0045	succinate-CoA ligase (ADP-forming) activity
S23_RS01900	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
S23_RS01910	COG0508	dehydrogenase complex catalyzes the overall conversion of
S23_RS01915	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS01920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S23_RS01940	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
S23_RS01950	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
S23_RS01955	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S23_RS01960	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
S23_RS01965	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
S23_RS01970	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
S23_RS01975	COG0355	proton-transporting ATP synthase activity, rotational mechanism
S23_RS01980	COG0494	nUDIX hydrolase
S23_RS01985	COG1051	belongs to the nudix hydrolase family
S23_RS01995	COG0793	Belongs to the peptidase S41A family
S23_RS02005	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
S23_RS02010	COG0799	negative regulation of ribosome biogenesis
S23_RS02015	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
S23_RS02020	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
S23_RS02030	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
S23_RS02045	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
S23_RS02065	COG0211	Belongs to the bacterial ribosomal protein bL27 family
S23_RS02070	COG0261	This protein binds to 23S rRNA in the presence of protein L20
S23_RS02155	COG0643	Histidine kinase
S23_RS02155	COG2198	Histidine kinase
S23_RS02160	COG0835	chemotaxis
S23_RS02165	COG0745	RESPONSE REGULATOR receiver
S23_RS02180	COG2201	protein-glutamate methylesterase activity
S23_RS02190	COG4566	intracellular signal transduction
S23_RS02195	COG4191	Histidine kinase
S23_RS02195	COG0784	Response regulator, receiver
S23_RS02200	COG4566	intracellular signal transduction
S23_RS02230	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
S23_RS02245	COG1696	Membrane protein involved in D-alanine export
S23_RS02255	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
S23_RS02280	COG2706	6-phosphogluconolactonase activity
S23_RS02300	COG0828	Belongs to the bacterial ribosomal protein bS21 family
S23_RS02305	COG5001	Diguanylate cyclase
S23_RS02340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S23_RS02375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S23_RS02390	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
S23_RS02400	COG1522	sequence-specific DNA binding
S23_RS02410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
S23_RS02445	COG0477	Major facilitator Superfamily
S23_RS02450	COG1877	trehalose-phosphatase activity
S23_RS02455	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
S23_RS02560	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
S23_RS02585	COG1475	DNA binding
S23_RS02620	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
S23_RS02625	COG0602	queuosine metabolic process
S23_RS02660	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
S23_RS02660	COG1672	PFAM Archaeal ATPase
S23_RS02685	COG1733	regulation of RNA biosynthetic process
S23_RS02690	COG0583	DNA-binding transcription factor activity
S23_RS02695	COG2814	Major facilitator Superfamily
S23_RS02700	COG0154	amidase activity
S23_RS02705	COG2873	o-acetylhomoserine
S23_RS02720	COG0514	ATP-dependent DNA helicase (RecQ)
S23_RS02725	COG2515	1-aminocyclopropane-1-carboxylate deaminase
S23_RS02730	COG1522	sequence-specific DNA binding
S23_RS02755	COG0657	acetylesterase activity
S23_RS02760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S23_RS02770	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
S23_RS02785	COG0697	spore germination
S23_RS02795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S23_RS02810	COG2890	protein-(glutamine-N5) methyltransferase activity
S23_RS02815	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
S23_RS02820	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
S23_RS02825	COG0527	aspartate kinase activity
S23_RS02835	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
S23_RS02850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S23_RS02860	COG1040	competence protein
S23_RS02880	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
S23_RS02885	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S23_RS02890	COG0653	protein targeting
S23_RS02925	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
S23_RS02935	COG3034	peptidoglycan biosynthetic process
S23_RS02940	COG0825	malonyl-CoA metabolic process
S23_RS02945	COG4974	Belongs to the 'phage' integrase family
S23_RS02955	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
S23_RS02960	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
S23_RS02965	COG4536	flavin adenine dinucleotide binding
S23_RS02970	COG0271	Belongs to the BolA IbaG family
S23_RS02980	COG0372	Belongs to the citrate synthase family
S23_RS02985	COG0372	Belongs to the citrate synthase family
S23_RS03020	COG2202	Pas domain
S23_RS03020	COG3920	Histidine kinase
S23_RS03045	COG1902	pentaerythritol trinitrate reductase activity
S23_RS03085	COG0227	Belongs to the bacterial ribosomal protein bL28 family
S23_RS03100	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
S23_RS03105	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
S23_RS03125	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
S23_RS03140	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
S23_RS03145	COG1845	cytochrome c oxidase, subunit III
S23_RS03150	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S23_RS03155	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
S23_RS03160	COG0477	Major facilitator Superfamily
S23_RS03180	COG1024	Enoyl-CoA hydratase
S23_RS03190	COG1024	Enoyl-CoA hydratase
S23_RS03195	COG1960	acyl-CoA dehydrogenase activity
S23_RS03210	COG2261	transglycosylase associated protein
S23_RS03220	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S23_RS03245	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
S23_RS03275	COG3964	amidohydrolase
S23_RS03280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S23_RS03295	COG0583	DNA-binding transcription factor activity
S23_RS03305	COG2207	Transcriptional regulator
S23_RS03325	COG1960	acyl-CoA dehydrogenase activity
S23_RS03340	COG2030	dehydratase
S23_RS03355	COG0318	PFAM AMP-dependent synthetase and ligase
S23_RS03370	COG1024	Enoyl-CoA hydratase
S23_RS03375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S23_RS03430	COG2130	NADP-dependent
S23_RS03435	COG1301	dicarboxylic acid transport
S23_RS03440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S23_RS03455	COG0069	glutamate synthase activity
S23_RS03465	COG1253	flavin adenine dinucleotide binding
S23_RS03485	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
S23_RS03510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S23_RS03515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S23_RS03530	COG2003	Belongs to the UPF0758 family
S23_RS03535	COG0024	Methionine aminopeptidase
S23_RS03540	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
S23_RS03540	COG3264	Mechanosensitive ion channel
S23_RS03545	COG3263	regulation of cellular component size
S23_RS03550	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
S23_RS03555	COG4149	molybdate abc transporter
S23_RS03560	COG0725	ABC transporter, periplasmic molybdate-binding protein
S23_RS03570	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
S23_RS03575	COG5001	Diguanylate cyclase
S23_RS03625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S23_RS03655	COG0481	GTPase activity
S23_RS03670	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S23_RS03670	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
S23_RS03675	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
S23_RS03680	COG2205	protein histidine kinase activity
S23_RS03685	COG0745	RESPONSE REGULATOR receiver
S23_RS03700	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
S23_RS03715	COG0058	SHG alpha-glucan phosphorylase activity
S23_RS03740	COG0625	glutathione transferase activity
S23_RS03750	COG1250	3-hydroxyacyl-CoA dehydrogenase
S23_RS03750	COG1024	Enoyl-CoA hydratase
S23_RS03755	COG0183	Belongs to the thiolase family
S23_RS03760	COG1960	acyl-CoA dehydrogenase activity
S23_RS03770	COG1695	Transcriptional regulator
S23_RS03780	COG0730	response to heat
S23_RS03800	COG0583	DNA-binding transcription factor activity
S23_RS03805	COG0681	Belongs to the peptidase S26 family
S23_RS03810	COG0312	modulator of DNA gyrase
S23_RS03820	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
S23_RS03825	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S23_RS03830	COG0109	protoheme IX farnesyltransferase activity
S23_RS03840	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
S23_RS03855	COG3346	SURF1 family
S23_RS03880	COG0612	Peptidase, M16
S23_RS03885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S23_RS03895	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
S23_RS03900	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
S23_RS03910	COG0356	it plays a direct role in the translocation of protons across the membrane
S23_RS03925	COG0432	Pfam Uncharacterised protein family UPF0047
S23_RS03945	COG1764	response to oxidative stress
S23_RS03950	COG0596	Alpha beta hydrolase
S23_RS03965	COG2205	protein histidine kinase activity
S23_RS03965	COG0784	Response regulator, receiver
S23_RS03970	COG0156	8-amino-7-oxononanoate synthase activity
S23_RS04015	COG4172	Belongs to the ABC transporter superfamily
S23_RS04020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S23_RS04025	COG0601	transmembrane transport
S23_RS04060	COG2020	methyltransferase activity
S23_RS04075	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
S23_RS04080	COG2309	aminopeptidase activity
S23_RS04095	COG3618	amidohydrolase
S23_RS04170	COG0747	negative chemotaxis
S23_RS04175	COG0747	negative chemotaxis
S23_RS04185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S23_RS04190	COG4608	Belongs to the ABC transporter superfamily
S23_RS04200	COG0154	amidase activity
S23_RS04205	COG0444	Belongs to the ABC transporter superfamily
S23_RS04215	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
S23_RS04220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S23_RS04225	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
S23_RS04235	COG1546	Belongs to the CinA family
S23_RS04235	COG1058	Belongs to the CinA family
S23_RS04260	COG0583	DNA-binding transcription factor activity
S23_RS04275	COG1024	Enoyl-CoA hydratase
S23_RS04280	COG4221	oxidoreductase activity
S23_RS04285	COG1960	acyl-CoA dehydrogenase activity
S23_RS04290	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
S23_RS04305	COG2267	carboxylic ester hydrolase activity
S23_RS04320	COG0179	Fumarylacetoacetate (FAA) hydrolase
S23_RS04340	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS04350	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS04370	COG0640	Transcriptional regulator
S23_RS04375	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS04410	COG0842	Transport permease protein
S23_RS04415	COG1129	ABC transporter
S23_RS04415	COG0842	Transport permease protein
S23_RS04420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S23_RS04425	COG1129	ABC transporter
S23_RS04440	COG1879	ABC-type sugar transport system periplasmic component
S23_RS04445	COG1172	Belongs to the binding-protein-dependent transport system permease family
S23_RS04450	COG0318	PFAM AMP-dependent synthetase and ligase
S23_RS04455	COG1917	Cupin 2, conserved barrel domain protein
S23_RS04455	COG2207	Transcriptional regulator
S23_RS04470	COG0604	alcohol dehydrogenase
S23_RS04475	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
S23_RS04495	COG2378	regulation of single-species biofilm formation
S23_RS04505	COG1024	Enoyl-CoA hydratase
S23_RS04510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S23_RS04565	COG1022	Amp-dependent synthetase and ligase
S23_RS04565	COG3320	Male sterility
S23_RS04570	COG1024	Enoyl-CoA hydratase
S23_RS04605	COG0583	DNA-binding transcription factor activity
S23_RS04690	COG0318	PFAM AMP-dependent synthetase and ligase
S23_RS04695	COG1960	acyl-CoA dehydrogenase activity
S23_RS04705	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS04710	COG2852	Protein conserved in bacteria
S23_RS04715	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
S23_RS04760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S23_RS04765	COG0077	Prephenate dehydratase
S23_RS04765	COG1605	Chorismate mutase
S23_RS04770	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
S23_RS04775	COG3474	cytochrome
S23_RS04780	COG4166	transmembrane transport
S23_RS04785	COG4166	transmembrane transport
S23_RS04790	COG4174	ABC transporter (Permease)
S23_RS04795	COG4239	(ABC) transporter, permease
S23_RS04800	COG4172	Belongs to the ABC transporter superfamily
S23_RS04810	COG0791	NLP P60 protein
S23_RS04815	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
S23_RS04860	COG4964	Belongs to the GSP D family
S23_RS04890	COG1278	Cold shock
S23_RS04895	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
S23_RS04900	COG0513	Belongs to the DEAD box helicase family
S23_RS04930	COG0829	nickel cation binding
S23_RS04935	COG0831	urea catabolic process
S23_RS04940	COG0832	Belongs to the urease beta subunit family
S23_RS04945	COG2852	Protein conserved in bacteria
S23_RS04950	COG0804	urea catabolic process
S23_RS04970	COG0830	nickel cation binding
S23_RS04975	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
S23_RS05005	COG0628	permease
S23_RS05010	COG1388	LysM domain
S23_RS05010	COG1376	ErfK ybiS ycfS ynhG family protein
S23_RS05030	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
S23_RS05040	COG0175	sulfate reduction
S23_RS05045	COG1648	precorrin-2 dehydrogenase activity
S23_RS05045	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S23_RS05055	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S23_RS05065	COG0175	sulfate reduction
S23_RS05070	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
S23_RS05075	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
S23_RS05080	COG4208	sulfate ABC transporter
S23_RS05085	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
S23_RS05100	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS05105	COG0730	response to heat
S23_RS05135	COG0583	DNA-binding transcription factor activity
S23_RS05150	COG1678	Uncharacterized ACR, COG1678
S23_RS05160	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS05165	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS05170	COG3237	CsbD-like
S23_RS05180	COG2951	lytic endotransglycosylase activity
S23_RS05185	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S23_RS05190	COG2203	Gaf domain
S23_RS05190	COG3706	GGDEF domain
S23_RS05190	COG4251	negative regulation of phosphorylation
S23_RS05190	COG5001	Diguanylate cyclase
S23_RS05205	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS05205	COG0604	alcohol dehydrogenase
S23_RS05205	COG3321	synthase
S23_RS05220	COG0254	rRNA binding
S23_RS05225	COG1132	(ABC) transporter
S23_RS05245	COG1116	anion transmembrane transporter activity
S23_RS05250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S23_RS05280	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
S23_RS05285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S23_RS05290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S23_RS05300	COG0483	inositol monophosphate 1-phosphatase activity
S23_RS05315	COG3588	fructose-bisphosphate aldolase
S23_RS05325	COG0126	phosphoglycerate kinase activity
S23_RS05355	COG1692	metallophosphoesterase
S23_RS05380	COG0840	transmembrane signaling receptor activity
S23_RS05390	COG0217	transcriptional regulatory protein
S23_RS05395	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
S23_RS05400	COG0632	four-way junction helicase activity
S23_RS05410	COG2255	four-way junction helicase activity
S23_RS05420	COG1408	metallophosphoesterase
S23_RS05425	COG0824	Thioesterase
S23_RS05435	COG0519	Catalyzes the synthesis of GMP from XMP
S23_RS05435	COG0518	GMP synthase (glutamine-hydrolyzing) activity
S23_RS05455	COG0765	amino acid transport
S23_RS05460	COG1126	abc transporter atp-binding protein
S23_RS05465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S23_RS05485	COG0402	S-adenosylhomocysteine deaminase activity
S23_RS05500	COG3842	ATPase activity
S23_RS05505	COG1176	ABC-type spermidine putrescine transport system, permease component I
S23_RS05510	COG1177	transmembrane transport
S23_RS05540	COG0488	(ABC) transporter
S23_RS05545	COG1301	dicarboxylic acid transport
S23_RS05550	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS05575	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
S23_RS05605	COG0625	glutathione transferase activity
S23_RS05610	COG1309	transcriptional regulator
S23_RS05620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S23_RS05625	COG3795	YCII-related domain
S23_RS05630	COG4941	Belongs to the sigma-70 factor family
S23_RS05655	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS05690	COG1045	serine acetyltransferase
S23_RS05710	COG0823	Involved in the tonB-independent uptake of proteins
S23_RS05715	COG5001	Diguanylate cyclase
S23_RS05725	COG2885	chlorophyll binding
S23_RS05735	COG0037	tRNA processing
S23_RS05740	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S23_RS05765	COG1309	transcriptional regulator
S23_RS05770	COG0469	pyruvate kinase activity
S23_RS05785	COG3750	Belongs to the UPF0335 family
S23_RS05795	COG3108	Peptidase M15
S23_RS05800	COG2989	Protein conserved in bacteria
S23_RS05805	COG2204	response regulator
S23_RS05845	COG0387	Pfam Sodium calcium exchanger
S23_RS05865	COG0828	Belongs to the bacterial ribosomal protein bS21 family
S23_RS05870	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S23_RS05875	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
S23_RS05880	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
S23_RS05885	COG5002	protein histidine kinase activity
S23_RS05885	COG3447	MASE1 domain protein
S23_RS05885	COG5001	Diguanylate cyclase
S23_RS05915	COG3300	MHYT domain
S23_RS05915	COG5001	Diguanylate cyclase
S23_RS05930	COG3842	ATPase activity
S23_RS05935	COG1176	ABC-type spermidine putrescine transport system, permease component I
S23_RS05940	COG1177	transmembrane transport
S23_RS05950	COG1175	transmembrane transport
S23_RS05990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S23_RS06015	COG4566	intracellular signal transduction
S23_RS06025	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
S23_RS06030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S23_RS06045	COG4771	TonB-dependent receptor
S23_RS06065	COG0848	biopolymer transport protein
S23_RS06085	COG0596	Alpha beta hydrolase
S23_RS06095	COG0395	ABC-type sugar transport system, permease component
S23_RS06100	COG1175	transmembrane transport
S23_RS06110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S23_RS06115	COG0840	transmembrane signaling receptor activity
S23_RS06140	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
S23_RS06150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S23_RS06155	COG4591	ABC-type transport system involved in lipoprotein release permease component
S23_RS06160	COG1136	(ABC) transporter
S23_RS06165	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
S23_RS06205	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S23_RS06210	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S23_RS06220	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
S23_RS06225	COG3005	denitrification pathway
S23_RS06230	COG3043	anaerobic respiration
S23_RS06235	COG0243	molybdopterin cofactor binding
S23_RS06250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S23_RS06275	COG2124	cytochrome p450
S23_RS06280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S23_RS06285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S23_RS06290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S23_RS06295	COG1116	anion transmembrane transporter activity
S23_RS06300	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S23_RS06310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S23_RS06325	COG2204	response regulator
S23_RS06330	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S23_RS06340	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S23_RS06345	COG1766	The M ring may be actively involved in energy transduction
S23_RS06355	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
S23_RS06365	COG0482	sulfurtransferase activity
S23_RS06410	COG2864	formate dehydrogenase
S23_RS06415	COG0437	4 iron, 4 sulfur cluster binding
S23_RS06420	COG0243	molybdopterin cofactor binding
S23_RS06420	COG3383	formate dehydrogenase (NAD+) activity
S23_RS06445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
S23_RS06450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S23_RS06455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S23_RS06480	COG3038	cytochrome b561
S23_RS06485	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
S23_RS06500	COG1271	oxidase subunit
S23_RS06505	COG1294	oxidase, subunit
S23_RS06510	COG2140	Oxalate decarboxylase
S23_RS06515	COG0243	molybdopterin cofactor binding
S23_RS06520	COG4191	Histidine kinase
S23_RS06530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S23_RS06560	COG3052	prosthetic group binding
S23_RS06580	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
S23_RS06595	COG1566	PFAM secretion protein HlyD family protein
S23_RS06605	COG1289	transmembrane transporter activity
S23_RS06615	COG4566	intracellular signal transduction
S23_RS06620	COG4191	Histidine kinase
S23_RS06665	COG1464	Belongs to the NlpA lipoprotein family
S23_RS06670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S23_RS06690	COG0559	Belongs to the binding-protein-dependent transport system permease family
S23_RS06695	COG0411	ABC transporter
S23_RS06705	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
S23_RS06750	COG1846	Transcriptional regulator
S23_RS06755	COG1157	protein secretion by the type III secretion system
S23_RS06760	COG4786	Flagellar basal body rod
S23_RS06770	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
S23_RS06785	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S23_RS06790	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S23_RS06795	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
S23_RS06800	COG1815	bacterial-type flagellum-dependent cell motility
S23_RS06805	COG1558	bacterial-type flagellum-dependent cell motility
S23_RS06810	COG1677	Flagellar hook-basal body complex protein FliE
S23_RS06815	COG4786	Flagellar basal body rod
S23_RS06825	COG1706	bacterial-type flagellum-dependent cell motility
S23_RS06835	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
S23_RS06845	COG1338	Plays a role in the flagellum-specific transport system
S23_RS06850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S23_RS06855	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S23_RS06860	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S23_RS06895	COG1749	Flagellar hook protein flgE
S23_RS06915	COG5443	negative regulation of bacterial-type flagellum assembly
S23_RS06920	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
S23_RS06925	COG4794	Type iii secretion
S23_RS06930	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
S23_RS06935	COG1684	flagellar biosynthetic protein fliR
S23_RS06975	COG0412	Dienelactone hydrolase
S23_RS07000	COG0246	Mannitol dehydrogenase
S23_RS07010	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
S23_RS07020	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
S23_RS07025	COG1063	alcohol dehydrogenase
S23_RS07035	COG0583	DNA-binding transcription factor activity
S23_RS07040	COG3842	ATPase activity
S23_RS07050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S23_RS07060	COG1176	ABC-type spermidine putrescine transport system, permease component I
S23_RS07065	COG4208	sulfate ABC transporter
S23_RS07090	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
S23_RS07100	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
S23_RS07110	COG0765	amino acid transport
S23_RS07120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S23_RS07125	COG0251	oxidation-reduction process
S23_RS07130	COG0436	Aminotransferase
S23_RS07135	COG0028	Belongs to the TPP enzyme family
S23_RS07140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S23_RS07165	COG0028	Belongs to the TPP enzyme family
S23_RS07165	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
S23_RS07170	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS07175	COG0395	ABC-type sugar transport system, permease component
S23_RS07180	COG1175	transmembrane transport
S23_RS07190	COG1609	Transcriptional regulator
S23_RS07200	COG1414	Transcriptional regulator
S23_RS07205	COG1053	succinate dehydrogenase
S23_RS07215	COG0477	Major facilitator Superfamily
S23_RS07235	COG3842	ATPase activity
S23_RS07260	COG0583	DNA-binding transcription factor activity
S23_RS07280	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
S23_RS07300	COG2030	dehydratase
S23_RS07310	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
S23_RS07330	COG0318	PFAM AMP-dependent synthetase and ligase
S23_RS07335	COG0427	acetyl-CoA hydrolase
S23_RS07355	COG1595	DNA-templated transcription, initiation
S23_RS07360	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S23_RS07365	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
S23_RS07385	COG1749	Flagellar hook protein flgE
S23_RS07415	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
S23_RS07425	COG1309	transcriptional regulator
S23_RS07445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S23_RS07470	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
S23_RS07475	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
S23_RS07480	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
S23_RS07485	COG2205	protein histidine kinase activity
S23_RS07495	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
S23_RS07515	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
S23_RS07525	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
S23_RS07530	COG0366	Alpha amylase catalytic
S23_RS07535	COG0366	Alpha amylase catalytic
S23_RS07540	COG1640	4-alpha-glucanotransferase
S23_RS07545	COG3387	PFAM Glycoside hydrolase 15-related
S23_RS07555	COG3265	gluconokinase activity
S23_RS07560	COG0363	glucosamine-6-phosphate deaminase activity
S23_RS07565	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
S23_RS07570	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
S23_RS07575	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
S23_RS07585	COG2766	serine protein kinase
S23_RS07590	COG2718	Belongs to the UPF0229 family
S23_RS07595	COG2719	SpoVR family
S23_RS07645	COG1013	pyruvate-flavodoxin oxidoreductase activity
S23_RS07650	COG0674	pyruvate-flavodoxin oxidoreductase activity
S23_RS07650	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
S23_RS07670	COG0535	radical SAM domain protein
S23_RS07675	COG0535	radical SAM domain protein
S23_RS07680	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
S23_RS07685	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
S23_RS07700	COG0154	amidase activity
S23_RS07705	COG0386	Belongs to the glutathione peroxidase family
S23_RS07735	COG2207	Transcriptional regulator
S23_RS07780	COG0747	negative chemotaxis
S23_RS07785	COG0601	transmembrane transport
S23_RS07790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S23_RS07795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S23_RS07800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S23_RS07830	COG4948	Mandelate Racemase Muconate Lactonizing
S23_RS07845	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
S23_RS07860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S23_RS07875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S23_RS07880	COG2897	thiosulfate sulfurtransferase activity
S23_RS07890	COG1376	ErfK ybiS ycfS ynhG family protein
S23_RS07895	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S23_RS07935	COG2193	ferroxidase activity
S23_RS07955	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
S23_RS07975	COG2204	response regulator
S23_RS07980	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS08020	COG0625	glutathione transferase activity
S23_RS08065	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
S23_RS08075	COG2022	thiamine diphosphate biosynthetic process
S23_RS08120	COG1177	transmembrane transport
S23_RS08125	COG1176	ABC-type spermidine putrescine transport system, permease component I
S23_RS08135	COG3842	ATPase activity
S23_RS08160	COG3474	cytochrome
S23_RS08165	COG1388	LysM domain
S23_RS08165	COG1376	ErfK ybiS ycfS ynhG family protein
S23_RS08190	COG0688	phosphatidylethanolamine metabolic process
S23_RS08230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S23_RS08235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S23_RS08240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S23_RS08265	COG1309	transcriptional regulator
S23_RS08280	COG5265	(ABC) transporter
S23_RS08320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S23_RS08330	COG3795	YCII-related domain
S23_RS08335	COG4941	Belongs to the sigma-70 factor family
S23_RS08340	COG3023	N-Acetylmuramoyl-L-alanine amidase
S23_RS08345	COG0275	rRNA processing
S23_RS08360	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
S23_RS08365	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
S23_RS08370	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S23_RS08375	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S23_RS08385	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S23_RS08390	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
S23_RS08395	COG0812	UDP-N-acetylmuramate dehydrogenase activity
S23_RS08400	COG1181	Belongs to the D-alanine--D-alanine ligase family
S23_RS08405	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
S23_RS08410	COG0849	cell division
S23_RS08415	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
S23_RS08425	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
S23_RS08435	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
S23_RS08440	COG2814	Major facilitator Superfamily
S23_RS08445	COG0006	proline dipeptidase activity
S23_RS08455	COG2264	protein methyltransferase activity
S23_RS08480	COG0584	glycerophosphoryl diester phosphodiesterase
S23_RS08500	COG0842	Transport permease protein
S23_RS08505	COG1131	(ABC) transporter
S23_RS08530	COG2267	carboxylic ester hydrolase activity
S23_RS08575	COG0071	Belongs to the small heat shock protein (HSP20) family
S23_RS08580	COG0071	Belongs to the small heat shock protein (HSP20) family
S23_RS08595	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
S23_RS08650	COG0210	DNA helicase
S23_RS08665	COG0277	FAD linked oxidase domain protein
S23_RS08685	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
S23_RS08695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S23_RS08705	COG3300	MHYT domain
S23_RS08705	COG5001	Diguanylate cyclase
S23_RS08710	COG2271	Major facilitator Superfamily
S23_RS08715	COG2200	EAL domain
S23_RS08715	COG2199	diguanylate cyclase activity
S23_RS08715	COG2202	Pas domain
S23_RS08720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S23_RS08735	COG2258	MOSC domain
S23_RS08745	COG0583	DNA-binding transcription factor activity
S23_RS08750	COG2271	Major facilitator Superfamily
S23_RS08760	COG2124	cytochrome p450
S23_RS08795	COG3258	Cytochrome c
S23_RS08815	COG0559	Belongs to the binding-protein-dependent transport system permease family
S23_RS08875	COG0114	fumarate hydratase activity
S23_RS08910	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
S23_RS08925	COG0330	HflC and HflK could
S23_RS08930	COG0330	HflC and HflK could
S23_RS08945	COG3830	Belongs to the UPF0237 family
S23_RS08945	COG0560	Phosphoserine phosphatase
S23_RS08950	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
S23_RS08955	COG0028	Belongs to the TPP enzyme family
S23_RS08965	COG0440	acetolactate synthase activity
S23_RS08985	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
S23_RS08990	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS09000	COG1174	glycine betaine transport
S23_RS09005	COG1125	glycine betaine transport
S23_RS09015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S23_RS09080	COG2326	polyphosphate kinase activity
S23_RS09085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S23_RS09090	COG0668	transmembrane transport
S23_RS09100	COG0281	malic enzyme
S23_RS09105	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
S23_RS09120	COG2072	flavoprotein involved in K transport
S23_RS09140	COG3384	dioxygenase
S23_RS09145	COG4095	Psort location CytoplasmicMembrane, score
S23_RS09150	COG0297	glycogen (starch) synthase activity
S23_RS09155	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
S23_RS09175	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
S23_RS09215	COG0559	Belongs to the binding-protein-dependent transport system permease family
S23_RS09230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S23_RS09280	COG0181	hydroxymethylbilane synthase activity
S23_RS09290	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
S23_RS09295	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
S23_RS09310	COG1233	COG1233 Phytoene dehydrogenase and related
S23_RS09315	COG1562	ergosterol biosynthetic process
S23_RS09320	COG0408	coproporphyrinogen oxidase activity
S23_RS09335	COG0142	geranyltranstransferase activity
S23_RS09340	COG0500	methyltransferase
S23_RS09345	COG1063	alcohol dehydrogenase
S23_RS09350	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
S23_RS09355	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
S23_RS09360	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
S23_RS09395	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
S23_RS09400	COG2211	Major facilitator Superfamily
S23_RS09405	COG0644	oxidoreductase
S23_RS09410	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
S23_RS09430	COG4251	negative regulation of phosphorylation
S23_RS09435	COG5398	heme oxygenase
S23_RS09450	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
S23_RS09455	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
S23_RS09460	COG1429	ligase activity, forming nitrogen-metal bonds
S23_RS09465	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
S23_RS09500	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
S23_RS09510	COG0156	8-amino-7-oxononanoate synthase activity
S23_RS09550	COG3119	arylsulfatase activity
S23_RS09560	COG3119	arylsulfatase activity
S23_RS09595	COG0346	lactoylglutathione lyase activity
S23_RS09610	COG0596	Alpha beta hydrolase
S23_RS09630	COG1574	metal-dependent hydrolase with the TIM-barrel fold
S23_RS09670	COG1960	acyl-CoA dehydrogenase activity
S23_RS09680	COG1802	Transcriptional regulator
S23_RS09685	COG4221	oxidoreductase activity
S23_RS09690	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS09735	COG2079	MmgE PrpD family protein
S23_RS09740	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S23_RS09745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S23_RS09750	COG1802	Transcriptional regulator
S23_RS09770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S23_RS09780	COG0179	Fumarylacetoacetate (FAA) hydrolase
S23_RS09785	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S23_RS09805	COG2169	Transcriptional regulator
S23_RS09820	COG0596	Alpha beta hydrolase
S23_RS09825	COG2267	carboxylic ester hydrolase activity
S23_RS09855	COG0596	Alpha beta hydrolase
S23_RS09860	COG1024	Enoyl-CoA hydratase
S23_RS09860	COG1250	3-hydroxyacyl-CoA dehydrogenase
S23_RS09865	COG1764	response to oxidative stress
S23_RS09875	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S23_RS09885	COG1566	PFAM secretion protein HlyD family protein
S23_RS09895	COG0656	L-ascorbic acid biosynthetic process
S23_RS09910	COG2223	nitrite transmembrane transporter activity
S23_RS09925	COG0577	efflux transmembrane transporter activity
S23_RS09925	COG1136	(ABC) transporter
S23_RS09930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S23_RS09945	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
S23_RS09960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S23_RS09980	COG1228	amidohydrolase
S23_RS09985	COG2986	histidine ammonia-lyase
S23_RS09990	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
S23_RS10080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S23_RS10080	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
S23_RS10085	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
S23_RS10090	COG0277	FAD linked oxidase domain protein
S23_RS10095	COG1250	3-hydroxyacyl-CoA dehydrogenase
S23_RS10105	COG0723	plastoquinol--plastocyanin reductase activity
S23_RS10135	COG3791	Glutathione-dependent formaldehyde-activating
S23_RS10140	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
S23_RS10165	COG3181	Tripartite tricarboxylate transporter family receptor
S23_RS10210	COG1116	anion transmembrane transporter activity
S23_RS10265	COG1131	(ABC) transporter
S23_RS10285	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
S23_RS10290	COG2197	response regulator
S23_RS10295	COG4585	Histidine kinase
S23_RS10300	COG4772	TonB-dependent receptor
S23_RS10330	COG2723	6-phospho-beta-galactosidase activity
S23_RS10335	COG0183	Belongs to the thiolase family
S23_RS10340	COG0776	regulation of translation
S23_RS10345	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
S23_RS10360	COG2095	MarC family integral membrane protein
S23_RS10365	COG0235	Class ii aldolase
S23_RS10405	COG2080	2 iron, 2 sulfur cluster binding
S23_RS10405	COG1529	Aldehyde oxidase and xanthine dehydrogenase
S23_RS10425	COG1079	Belongs to the binding-protein-dependent transport system permease family
S23_RS10430	COG4603	Belongs to the binding-protein-dependent transport system permease family
S23_RS10435	COG3845	ABC transporter
S23_RS10450	COG3845	ABC transporter
S23_RS10460	COG1079	Belongs to the binding-protein-dependent transport system permease family
S23_RS10465	COG1079	Belongs to the binding-protein-dependent transport system permease family
S23_RS10485	COG1301	dicarboxylic acid transport
S23_RS10490	COG0024	Methionine aminopeptidase
S23_RS10565	COG2010	Cytochrome c
S23_RS10585	COG3300	MHYT domain
S23_RS10585	COG5001	Diguanylate cyclase
S23_RS10605	COG4948	Mandelate Racemase Muconate Lactonizing
S23_RS10640	COG2084	Dehydrogenase
S23_RS10650	COG0129	dihydroxy-acid dehydratase activity
S23_RS10660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S23_RS10665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S23_RS10675	COG1250	3-hydroxyacyl-CoA dehydrogenase
S23_RS10685	COG0318	PFAM AMP-dependent synthetase and ligase
S23_RS10700	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS10705	COG1024	Enoyl-CoA hydratase
S23_RS10740	COG0251	oxidation-reduction process
S23_RS10745	COG0517	IMP dehydrogenase activity
S23_RS10745	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
S23_RS10745	COG0617	tRNA 3'-terminal CCA addition
S23_RS10750	COG3243	poly(R)-hydroxyalkanoic acid synthase
S23_RS10795	COG1127	ABC transporter
S23_RS10800	COG3218	ABC-type transport auxiliary lipoprotein component
S23_RS10800	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
S23_RS10805	COG2010	Cytochrome c
S23_RS10810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S23_RS10820	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
S23_RS10825	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
S23_RS10840	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS10850	COG1529	Aldehyde oxidase and xanthine dehydrogenase
S23_RS10850	COG2010	Cytochrome c
S23_RS10855	COG2080	2 iron, 2 sulfur cluster binding
S23_RS10860	COG3181	Tripartite tricarboxylate transporter family receptor
S23_RS10865	COG0243	molybdopterin cofactor binding
S23_RS10875	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
S23_RS10885	COG0247	lactate metabolic process
S23_RS10885	COG0277	FAD linked oxidase domain protein
S23_RS10890	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
S23_RS10895	COG1024	Enoyl-CoA hydratase
S23_RS10900	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
S23_RS10905	COG3181	Tripartite tricarboxylate transporter family receptor
S23_RS10920	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
S23_RS10925	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
S23_RS10930	COG1804	L-carnitine dehydratase bile acid-inducible protein F
S23_RS10965	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
S23_RS10985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S23_RS10990	COG3959	Transketolase, thiamine diphosphate binding domain
S23_RS10995	COG3958	Transketolase
S23_RS11000	COG0463	Glycosyl transferase, family 2
S23_RS11050	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S23_RS11080	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
S23_RS11095	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
S23_RS11105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S23_RS11115	COG2942	2-epimerase
S23_RS11135	COG0559	Belongs to the binding-protein-dependent transport system permease family
S23_RS11140	COG2852	Protein conserved in bacteria
S23_RS11145	COG0318	PFAM AMP-dependent synthetase and ligase
S23_RS11205	COG1137	ATPase activity
S23_RS11215	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S23_RS11230	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
S23_RS11235	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
S23_RS11245	COG2072	flavoprotein involved in K transport
S23_RS11260	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS11265	COG0583	DNA-binding transcription factor activity
S23_RS11285	COG1132	(ABC) transporter
S23_RS11310	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
S23_RS11345	COG0583	DNA-binding transcription factor activity
S23_RS11355	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
S23_RS11360	COG0859	PFAM glycosyl transferase family 9
S23_RS11370	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
S23_RS11370	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
S23_RS11395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S23_RS11415	COG0673	inositol 2-dehydrogenase activity
S23_RS11440	COG3909	cytochrome
S23_RS11460	COG2010	Cytochrome c
S23_RS11470	COG1215	transferase activity, transferring glycosyl groups
S23_RS11490	COG0351	phosphomethylpyrimidine kinase
S23_RS11500	COG0438	transferase activity, transferring glycosyl groups
S23_RS11535	COG2814	Major facilitator Superfamily
S23_RS11540	COG4948	Mandelate Racemase Muconate Lactonizing
S23_RS11545	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
S23_RS11550	COG1127	ABC transporter
S23_RS11555	COG3218	ABC-type transport auxiliary lipoprotein component
S23_RS11555	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
S23_RS11570	COG0633	Ferredoxin
S23_RS11580	COG0492	ferredoxin-NADP+ reductase activity
S23_RS11605	COG2721	sulfolactate sulfo-lyase activity
S23_RS11610	COG1012	belongs to the aldehyde dehydrogenase family
S23_RS11615	COG4948	Mandelate Racemase Muconate Lactonizing
S23_RS11620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S23_RS11625	COG0583	DNA-binding transcription factor activity
S23_RS11645	COG3685	Protein conserved in bacteria
S23_RS11665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S23_RS11685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S23_RS11690	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S23_RS11695	COG1749	Flagellar hook protein flgE
S23_RS11725	COG0076	glutamate decarboxylase activity
S23_RS11730	COG5443	negative regulation of bacterial-type flagellum assembly
S23_RS11735	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S23_RS11770	COG1706	bacterial-type flagellum-dependent cell motility
S23_RS11780	COG1733	regulation of RNA biosynthetic process
S23_RS11785	COG2910	NAD(P)H-binding
S23_RS11795	COG1733	regulation of RNA biosynthetic process
S23_RS11800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S23_RS11805	COG3971	2-oxopent-4-enoate hydratase activity
S23_RS11810	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
S23_RS11820	COG4786	Flagellar basal body rod
S23_RS11825	COG4786	Flagellar basal body rod
S23_RS11860	COG1338	Plays a role in the flagellum-specific transport system
S23_RS11870	COG1815	bacterial-type flagellum-dependent cell motility
S23_RS11875	COG1558	bacterial-type flagellum-dependent cell motility
S23_RS11880	COG1677	Flagellar hook-basal body complex protein FliE
S23_RS11885	COG1987	bacterial-type flagellum assembly
S23_RS11890	COG1684	flagellar biosynthetic protein fliR
S23_RS11895	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
S23_RS11920	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
S23_RS11920	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
S23_RS11935	COG2917	probably involved in intracellular septation
S23_RS11980	COG0784	Response regulator, receiver
S23_RS11980	COG2198	Histidine kinase
S23_RS11980	COG2205	protein histidine kinase activity
S23_RS11990	COG2172	sigma factor antagonist activity
S23_RS11995	COG1366	Belongs to the anti-sigma-factor antagonist family
S23_RS12000	COG1366	Belongs to the anti-sigma-factor antagonist family
S23_RS12065	COG0446	pyridine nucleotide-disulphide oxidoreductase
S23_RS12070	COG0640	Transcriptional regulator
S23_RS12105	COG4993	Dehydrogenase
S23_RS12155	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
S23_RS12175	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S23_RS12175	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S23_RS12180	COG0509	glycine decarboxylation via glycine cleavage system
S23_RS12185	COG0404	The glycine cleavage system catalyzes the degradation of glycine
S23_RS12190	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
S23_RS12195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S23_RS12210	COG0538	isocitrate dehydrogenase activity
S23_RS12225	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS12230	COG0583	DNA-binding transcription factor activity
S23_RS12245	COG0604	alcohol dehydrogenase
S23_RS12250	COG2909	trisaccharide binding
S23_RS12255	COG2020	methyltransferase activity
S23_RS12260	COG2267	carboxylic ester hydrolase activity
S23_RS12265	COG1309	transcriptional regulator
S23_RS12290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S23_RS12295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S23_RS12300	COG1116	anion transmembrane transporter activity
S23_RS12300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S23_RS12305	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
S23_RS12315	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
S23_RS12320	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S23_RS12325	COG0047	phosphoribosylformylglycinamidine synthase activity
S23_RS12330	COG3181	Tripartite tricarboxylate transporter family receptor
S23_RS12345	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S23_RS12385	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
S23_RS12390	COG1262	PFAM Formylglycine-generating sulfatase enzyme
S23_RS12395	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
S23_RS12400	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
S23_RS12420	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
S23_RS12455	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S23_RS12490	COG0583	DNA-binding transcription factor activity
S23_RS12495	COG0318	PFAM AMP-dependent synthetase and ligase
S23_RS12510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S23_RS12520	COG1473	amidohydrolase
S23_RS12525	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
S23_RS12530	COG1309	transcriptional regulator
S23_RS12565	COG0515	serine threonine protein kinase
S23_RS12565	COG2815	serine threonine protein kinase
S23_RS12595	COG0784	Response regulator, receiver
S23_RS12595	COG4191	Histidine kinase
S23_RS12600	COG2204	response regulator
S23_RS12635	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S23_RS12640	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
S23_RS12645	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
S23_RS12680	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
S23_RS12680	COG3608	succinylglutamate desuccinylase aspartoacylase
S23_RS12720	COG0640	Transcriptional regulator
S23_RS12735	COG1131	(ABC) transporter
S23_RS12740	COG0842	Transport permease protein
S23_RS12750	COG0384	phenazine biosynthesis protein PhzF
S23_RS12825	COG0681	Belongs to the peptidase S26 family
S23_RS12835	COG0459	protein refolding
S23_RS12840	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
S23_RS12845	COG5425	PFAM Usg family protein
S23_RS12855	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S23_RS12865	COG4221	oxidoreductase activity
S23_RS12890	COG2308	Evidence 4 Homologs of previously reported genes of
S23_RS12895	COG1546	Belongs to the CinA family
S23_RS12895	COG1058	Belongs to the CinA family
S23_RS12900	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
S23_RS12915	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S23_RS12920	COG0625	glutathione transferase activity
S23_RS12930	COG3321	synthase
S23_RS12930	COG0604	alcohol dehydrogenase
S23_RS12935	COG1024	Enoyl-CoA hydratase
S23_RS12945	COG1473	amidohydrolase
S23_RS12960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S23_RS12965	COG0601	transmembrane transport
S23_RS12980	COG0747	negative chemotaxis
S23_RS12985	COG0747	negative chemotaxis
S23_RS12995	COG2814	Major facilitator Superfamily
S23_RS13005	COG1024	Enoyl-CoA hydratase
S23_RS13030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S23_RS13045	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
S23_RS13115	COG3833	ABC-type maltose transport systems, permease component
S23_RS13120	COG1176	ABC-type spermidine putrescine transport system, permease component I
S23_RS13130	COG3842	ATPase activity
S23_RS13160	COG1063	alcohol dehydrogenase
S23_RS13220	COG0517	IMP dehydrogenase activity
S23_RS13225	COG1752	Esterase of the alpha-beta hydrolase superfamily
S23_RS13265	COG5001	Diguanylate cyclase
S23_RS13290	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
S23_RS13295	COG2814	Major facilitator Superfamily
S23_RS13315	COG0531	amino acid
S23_RS13330	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
S23_RS13345	COG0302	gtp cyclohydrolase
S23_RS13350	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
S23_RS13380	COG3655	Transcriptional regulator
S23_RS13390	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S23_RS13445	COG0840	transmembrane signaling receptor activity
S23_RS13465	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
S23_RS13795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S23_RS13805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S23_RS13815	COG0210	DNA helicase
S23_RS13825	COG3795	YCII-related domain
S23_RS13865	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
S23_RS13870	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
S23_RS13870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
S23_RS13880	COG1802	Transcriptional regulator
S23_RS13885	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS13900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S23_RS13930	COG3246	L-lysine catabolic process to acetate
S23_RS13950	COG1960	acyl-CoA dehydrogenase activity
S23_RS13970	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS13975	COG0406	alpha-ribazole phosphatase activity
S23_RS13980	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS14000	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
S23_RS14005	COG0250	Participates in transcription elongation, termination and antitermination
S23_RS14010	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
S23_RS14015	COG0081	regulation of translation
S23_RS14020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S23_RS14025	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
S23_RS14030	COG0222	ribosome binding
S23_RS14035	COG0085	RNA polymerase activity
S23_RS14040	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
S23_RS14045	COG1231	oxidoreductase activity
S23_RS14050	COG1132	(ABC) transporter
S23_RS14055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S23_RS14060	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
S23_RS14065	COG0049	tRNA binding
S23_RS14070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
S23_RS14075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
S23_RS14080	COG0051	transcription antitermination factor activity, RNA binding
S23_RS14085	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
S23_RS14090	COG0088	Forms part of the polypeptide exit tunnel
S23_RS14095	COG0089	rRNA binding
S23_RS14100	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
S23_RS14105	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
S23_RS14110	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
S23_RS14115	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
S23_RS14120	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
S23_RS14125	COG0255	Belongs to the universal ribosomal protein uL29 family
S23_RS14130	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
S23_RS14135	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
S23_RS14140	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
S23_RS14145	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
S23_RS14150	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S23_RS14155	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
S23_RS14160	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
S23_RS14165	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
S23_RS14170	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
S23_RS14175	COG1841	ribosomal large subunit assembly
S23_RS14180	COG0200	Binds to the 23S rRNA
S23_RS14190	COG0563	adenylate kinase activity
S23_RS14195	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
S23_RS14200	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
S23_RS14205	COG0202	RNA polymerase activity
S23_RS14210	COG0203	ribosomal protein L17
S23_RS14220	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS14240	COG1733	regulation of RNA biosynthetic process
S23_RS14255	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
S23_RS14280	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
S23_RS14305	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S23_RS14370	COG2860	membrane
S23_RS14375	COG2010	Cytochrome c
S23_RS14375	COG1529	Aldehyde oxidase and xanthine dehydrogenase
S23_RS14395	COG2030	dehydratase
S23_RS14400	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS14455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S23_RS14465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S23_RS14520	COG0415	Belongs to the DNA photolyase family
S23_RS14525	COG0450	alkyl hydroperoxide reductase
S23_RS14540	COG2197	response regulator
S23_RS14545	COG0577	efflux transmembrane transporter activity
S23_RS14545	COG1136	(ABC) transporter
S23_RS14550	COG1136	(ABC) transporter
S23_RS14550	COG0577	efflux transmembrane transporter activity
S23_RS14555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S23_RS14565	COG4566	intracellular signal transduction
S23_RS14605	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS14635	COG1804	L-carnitine dehydratase bile acid-inducible protein F
S23_RS14655	COG0179	Fumarylacetoacetate (FAA) hydrolase
S23_RS14660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S23_RS14670	COG2124	cytochrome p450
S23_RS14675	COG1414	Transcriptional regulator
S23_RS14685	COG1234	tRNA 3'-trailer cleavage
S23_RS14690	COG2197	response regulator
S23_RS14695	COG3851	Histidine kinase
S23_RS14705	COG1063	alcohol dehydrogenase
S23_RS14710	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS14715	COG4948	Mandelate Racemase Muconate Lactonizing
S23_RS14725	COG2271	Major facilitator Superfamily
S23_RS14735	COG0471	metal ion transport
S23_RS14735	COG3273	potassium ion transport
S23_RS14755	COG2204	response regulator
S23_RS14760	COG4191	Histidine kinase
S23_RS14780	COG4770	biotin carboxylase activity
S23_RS14785	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
S23_RS14790	COG1254	Belongs to the acylphosphatase family
S23_RS14810	COG0305	Participates in initiation and elongation during chromosome replication
S23_RS14815	COG0321	lipoyl(octanoyl) transferase activity
S23_RS14830	COG4977	sequence-specific DNA binding
S23_RS14845	COG0523	cobalamin synthesis protein
S23_RS14870	COG2239	Acts as a magnesium transporter
S23_RS14880	COG0656	L-ascorbic acid biosynthetic process
S23_RS14915	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
S23_RS14920	COG1192	Involved in chromosome partitioning
S23_RS14940	COG1686	Belongs to the peptidase S11 family
S23_RS14950	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
S23_RS14965	COG2814	Major facilitator Superfamily
S23_RS14975	COG0667	Aldo Keto reductase
S23_RS14985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S23_RS15050	COG1720	tRNA m6t6A37 methyltransferase activity
S23_RS15055	COG0537	adenosine 5'-monophosphoramidase activity
S23_RS15085	COG0494	nUDIX hydrolase
S23_RS15095	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S23_RS15105	COG0784	Response regulator, receiver
S23_RS15160	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
S23_RS15170	COG0267	Belongs to the bacterial ribosomal protein bL33 family
S23_RS15190	COG0557	exoribonuclease II activity
S23_RS15195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S23_RS15210	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS15220	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S23_RS15225	COG1733	regulation of RNA biosynthetic process
S23_RS15230	COG0758	DNA mediated transformation
S23_RS15235	COG0154	amidase activity
S23_RS15245	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
S23_RS15250	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S23_RS15255	COG0540	Belongs to the ATCase OTCase family
S23_RS15265	COG1960	acyl-CoA dehydrogenase activity
S23_RS15280	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
S23_RS15290	COG0583	DNA-binding transcription factor activity
S23_RS15300	COG2070	2-Nitropropane dioxygenase
S23_RS15305	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S23_RS15315	COG0154	amidase activity
S23_RS15325	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S23_RS15345	COG0741	lytic transglycosylase activity
S23_RS15350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S23_RS15355	COG1970	mechanosensitive ion channel activity
S23_RS15360	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
S23_RS15380	COG1758	RNA polymerase activity
S23_RS15390	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
S23_RS15395	COG0736	holo-[acyl-carrier-protein] synthase activity
S23_RS15400	COG0681	Belongs to the peptidase S26 family
S23_RS15405	COG0571	ribonuclease III activity
S23_RS15410	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
S23_RS15420	COG1381	Involved in DNA repair and RecF pathway recombination
S23_RS15430	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S23_RS15435	COG0747	negative chemotaxis
S23_RS15450	COG2059	Chromate
S23_RS15465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S23_RS15470	COG0697	spore germination
S23_RS15485	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
S23_RS15495	COG1914	H( )-stimulated, divalent metal cation uptake system
S23_RS15500	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
S23_RS15510	COG0113	porphobilinogen synthase activity
S23_RS15535	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
S23_RS15540	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
S23_RS15545	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S23_RS15545	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S23_RS15555	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
S23_RS15560	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S23_RS15565	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
S23_RS15575	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
S23_RS15600	COG0416	fatty acid biosynthetic process
S23_RS15605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S23_RS15610	COG0776	regulation of translation
S23_RS15630	COG2200	EAL domain
S23_RS15640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S23_RS15690	COG3268	Saccharopine dehydrogenase
S23_RS15695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S23_RS15700	COG1846	Transcriptional regulator
S23_RS15715	COG0438	transferase activity, transferring glycosyl groups
S23_RS15740	COG1612	heme a metabolic process
S23_RS15760	COG1024	Enoyl-CoA hydratase
S23_RS15770	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
S23_RS15775	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
S23_RS15805	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
S23_RS15820	COG0174	glutamine synthetase
S23_RS15825	COG0347	Belongs to the P(II) protein family
S23_RS15830	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
S23_RS15830	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
S23_RS15840	COG2132	Multicopper oxidase
S23_RS15850	COG0544	peptidyl-prolyl cis-trans isomerase activity
S23_RS15855	COG0740	serine-type endopeptidase activity
S23_RS15860	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
S23_RS15865	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
S23_RS15880	COG2226	methyltransferase
S23_RS15885	COG1230	cation diffusion facilitator family transporter
S23_RS15915	COG1960	acyl-CoA dehydrogenase activity
S23_RS15920	COG2195	Cleaves the N-terminal amino acid of tripeptides
S23_RS15925	COG0776	regulation of translation
S23_RS15940	COG2814	Major facilitator Superfamily
S23_RS15955	COG4774	siderophore transport
S23_RS15965	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
S23_RS15975	COG0649	NAD binding
S23_RS15985	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
S23_RS15995	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
S23_RS16005	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
S23_RS16010	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
S23_RS16020	COG0713	ATP synthesis coupled electron transport
S23_RS16035	COG1007	ATP synthesis coupled electron transport
S23_RS16040	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
S23_RS16040	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
S23_RS16050	COG0346	lactoylglutathione lyase activity
S23_RS16075	COG1454	alcohol dehydrogenase
S23_RS16085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S23_RS16090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S23_RS16110	COG0583	DNA-binding transcription factor activity
S23_RS16115	COG0251	oxidation-reduction process
S23_RS16125	COG1172	Belongs to the binding-protein-dependent transport system permease family
S23_RS16130	COG1129	ABC transporter
S23_RS16150	COG4774	siderophore transport
S23_RS16160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S23_RS16185	COG0442	prolyl-tRNA aminoacylation
S23_RS16195	COG1136	(ABC) transporter
S23_RS16215	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
S23_RS16220	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
S23_RS16240	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
S23_RS16250	COG2814	Major facilitator Superfamily
S23_RS16285	COG0052	Belongs to the universal ribosomal protein uS2 family
S23_RS16290	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
S23_RS16295	COG0528	UMP kinase activity
S23_RS16300	COG0233	cytoplasmic translational termination
S23_RS16305	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
S23_RS16315	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
S23_RS16320	COG0750	zinc metalloprotease
S23_RS16325	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
S23_RS16330	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
S23_RS16335	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S23_RS16345	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
S23_RS16355	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
S23_RS16360	COG0372	Belongs to the citrate synthase family
S23_RS16365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S23_RS16370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S23_RS16405	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
S23_RS16410	COG0303	'Molybdopterin
S23_RS16420	COG1011	Hydrolase
S23_RS16425	COG1304	FMN binding
S23_RS16430	COG0793	Belongs to the peptidase S41A family
S23_RS16435	COG3300	MHYT domain
S23_RS16435	COG5001	Diguanylate cyclase
S23_RS16445	COG0315	cyclic pyranopterin monophosphate synthase activity
S23_RS16450	COG0134	indole-3-glycerol-phosphate synthase activity
S23_RS16455	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
S23_RS16460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S23_RS16470	COG0149	triose-phosphate isomerase activity
S23_RS16480	COG0504	CTP synthase activity
S23_RS16485	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
S23_RS16490	COG2205	protein histidine kinase activity
S23_RS16495	COG0745	RESPONSE REGULATOR receiver
S23_RS16505	COG2877	3-deoxy-8-phosphooctulonate synthase activity
S23_RS16520	COG2066	Belongs to the glutaminase family
S23_RS16520	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
S23_RS16530	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
S23_RS16535	COG0148	phosphopyruvate hydratase activity
S23_RS16540	COG1063	alcohol dehydrogenase
S23_RS16545	COG4221	oxidoreductase activity
S23_RS16550	COG4977	sequence-specific DNA binding
S23_RS16550	COG1917	Cupin 2, conserved barrel domain protein
S23_RS16560	COG0431	NADPH-dependent FMN reductase
S23_RS16570	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S23_RS16575	COG0022	dehydrogenase e1 component
S23_RS16575	COG0508	dehydrogenase complex catalyzes the overall conversion of
S23_RS16590	COG0508	dehydrogenase complex catalyzes the overall conversion of
S23_RS16600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S23_RS16605	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
S23_RS16615	COG0741	lytic transglycosylase activity
S23_RS16640	COG4206	TonB-dependent receptor
S23_RS16650	COG0129	dihydroxy-acid dehydratase activity
S23_RS16655	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
S23_RS16660	COG0708	Exodeoxyribonuclease III
S23_RS16665	COG5002	protein histidine kinase activity
S23_RS16665	COG2198	Histidine kinase
S23_RS16665	COG0784	Response regulator, receiver
S23_RS16680	COG0316	Belongs to the HesB IscA family
S23_RS16685	COG0232	Belongs to the dGTPase family. Type 2 subfamily
S23_RS16690	COG0018	arginyl-trna synthetase
S23_RS16700	COG1472	Belongs to the glycosyl hydrolase 3 family
S23_RS16705	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
S23_RS16710	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
S23_RS16715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S23_RS16720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S23_RS16725	COG0805	protein transport
S23_RS16730	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
S23_RS16740	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
S23_RS16750	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
S23_RS16755	COG4942	peptidase
S23_RS16765	COG1862	Preprotein translocase
S23_RS16770	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S23_RS16790	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
S23_RS16795	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S23_RS16800	COG2340	Cysteine-rich secretory protein family
S23_RS16810	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
S23_RS16890	COG0546	phosphoglycolate phosphatase activity
S23_RS16900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
S23_RS16925	COG0629	single-stranded DNA binding
S23_RS16930	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S23_RS16935	COG3158	transport of potassium into the cell
S23_RS16945	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
S23_RS16965	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
S23_RS16975	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
S23_RS16985	COG1309	transcriptional regulator
S23_RS16995	COG0343	queuine tRNA-ribosyltransferase activity
S23_RS17035	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
S23_RS17050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S23_RS17065	COG0628	permease
S23_RS17150	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
S23_RS17165	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
S23_RS17180	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S23_RS17195	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
S23_RS17200	COG1278	Cold shock
S23_RS17240	COG0679	Auxin Efflux Carrier
S23_RS17245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S23_RS17250	COG1183	phosphatidylcholine synthase activity
S23_RS17255	COG1253	flavin adenine dinucleotide binding
S23_RS17265	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S23_RS17285	COG0789	Transcriptional regulator
S23_RS17290	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S23_RS17295	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S23_RS17300	COG3707	response regulator
S23_RS17305	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S23_RS17310	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S23_RS17315	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S23_RS17320	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
S23_RS17325	COG1984	allophanate hydrolase subunit 2
S23_RS17335	COG0473	3-isopropylmalate dehydrogenase activity
S23_RS17335	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
S23_RS17350	COG2031	fatty acid transporter
S23_RS17385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S23_RS17395	COG0395	ABC-type sugar transport system, permease component
S23_RS17400	COG1175	transmembrane transport
S23_RS17430	COG1335	isochorismatase
S23_RS17440	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
S23_RS17440	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S23_RS17460	COG0444	Belongs to the ABC transporter superfamily
S23_RS17470	COG0601	transmembrane transport
S23_RS17475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S23_RS17480	COG0129	dihydroxy-acid dehydratase activity
S23_RS17495	COG0628	permease
S23_RS17510	COG4566	intracellular signal transduction
S23_RS17525	COG2985	domain, Protein
S23_RS17545	COG2985	domain, Protein
S23_RS17550	COG2985	domain, Protein
S23_RS17580	COG1566	PFAM secretion protein HlyD family protein
S23_RS17585	COG4191	Histidine kinase
S23_RS17585	COG2205	protein histidine kinase activity
S23_RS17585	COG0745	RESPONSE REGULATOR receiver
S23_RS17590	COG3064	Membrane
S23_RS17615	COG1278	Cold shock
S23_RS17665	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
S23_RS17670	COG2267	carboxylic ester hydrolase activity
S23_RS17675	COG1686	Belongs to the peptidase S11 family
S23_RS17680	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
S23_RS17695	COG0084	hydrolase, TatD family'
S23_RS17700	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
S23_RS17700	COG0321	lipoyl(octanoyl) transferase activity
S23_RS17720	COG0318	PFAM AMP-dependent synthetase and ligase
S23_RS17730	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
S23_RS17800	COG1566	PFAM secretion protein HlyD family protein
S23_RS17825	COG3119	arylsulfatase activity
S23_RS17830	COG1262	PFAM Formylglycine-generating sulfatase enzyme
S23_RS17840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
S23_RS17840	COG0574	Belongs to the PEP-utilizing enzyme family
S23_RS17855	COG4178	(ABC) transporter
S23_RS17860	COG1408	metallophosphoesterase
S23_RS17885	COG1053	succinate dehydrogenase
S23_RS17895	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
S23_RS17900	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
S23_RS17905	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
S23_RS17910	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
S23_RS17945	COG0617	tRNA 3'-terminal CCA addition
S23_RS17945	COG0517	IMP dehydrogenase activity
S23_RS17945	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
S23_RS17970	COG1464	Belongs to the NlpA lipoprotein family
S23_RS17975	COG2011	ABC-type metal ion transport system permease component
S23_RS17980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
S23_RS17985	COG1024	Enoyl-CoA hydratase
S23_RS18025	COG1120	ATPase activity
S23_RS18030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S23_RS18035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S23_RS18045	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
S23_RS18050	COG3956	TIGRFAM MazG family protein
S23_RS18055	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
S23_RS18060	COG1923	regulation of RNA biosynthetic process
S23_RS18065	COG2204	response regulator
S23_RS18070	COG5000	phosphorelay sensor kinase activity
S23_RS18090	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
S23_RS18090	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
S23_RS18095	COG1546	Belongs to the CinA family
S23_RS18095	COG1058	Belongs to the CinA family
S23_RS18100	COG2863	cytochrome
S23_RS18105	COG1529	Aldehyde oxidase and xanthine dehydrogenase
S23_RS18105	COG2010	Cytochrome c
S23_RS18120	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S23_RS18125	COG2863	cytochrome
S23_RS18130	COG2867	negative regulation of translational initiation
S23_RS18135	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
S23_RS18140	COG2094	Belongs to the DNA glycosylase MPG family
S23_RS18145	COG0525	valine-tRNA ligase activity
S23_RS18160	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
S23_RS18180	COG0251	oxidation-reduction process
S23_RS18195	COG1126	abc transporter atp-binding protein
S23_RS18220	COG2226	methyltransferase
S23_RS18245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S23_RS18265	COG1126	abc transporter atp-binding protein
S23_RS18270	COG0765	amino acid transport
S23_RS18275	COG4597	amino acid ABC transporter
S23_RS18280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S23_RS18285	COG0626	cystathionine gamma-synthase activity
S23_RS18290	COG1283	sodium-dependent phosphate transmembrane transporter activity
S23_RS18300	COG0463	Glycosyl transferase, family 2
S23_RS18305	COG0671	phosphoesterase, PA-phosphatase related
S23_RS18315	COG4953	penicillin-binding protein 1C
S23_RS18320	COG2373	Large extracellular alpha-helical protein
S23_RS18345	COG3654	unkown
S23_RS18395	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
S23_RS18420	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
S23_RS18420	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
S23_RS18425	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
S23_RS18430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S23_RS18440	COG4770	biotin carboxylase activity
S23_RS18445	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S23_RS18450	COG1960	acyl-CoA dehydrogenase activity
S23_RS18465	COG1522	sequence-specific DNA binding
S23_RS18515	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
S23_RS18540	COG0776	regulation of translation
S23_RS18600	COG0625	glutathione transferase activity
S23_RS18635	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
S23_RS18855	COG3750	Belongs to the UPF0335 family
S23_RS18950	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
S23_RS18970	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
S23_RS18980	COG2354	Protein conserved in bacteria
S23_RS18990	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S23_RS19030	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
S23_RS19035	COG0840	transmembrane signaling receptor activity
S23_RS19050	COG1262	PFAM Formylglycine-generating sulfatase enzyme
S23_RS19060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S23_RS19065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S23_RS19075	COG1672	PFAM Archaeal ATPase
S23_RS19075	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
S23_RS19105	COG1494	fructose-1,6-bisphosphatase
S23_RS19115	COG0436	Aminotransferase
S23_RS19125	COG3243	poly(R)-hydroxyalkanoic acid synthase
S23_RS19140	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
S23_RS19155	COG0586	Pfam SNARE associated Golgi protein
S23_RS19160	COG0187	DNA topoisomerase II activity
S23_RS19175	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS19210	COG0513	Belongs to the DEAD box helicase family
S23_RS19220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S23_RS19230	COG0316	Belongs to the HesB IscA family
S23_RS19240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S23_RS19245	COG0719	Fe-S assembly protein
S23_RS19250	COG0396	ATPase activity
S23_RS19255	COG0719	Fe-S assembly protein
S23_RS19260	COG1104	cysteine desulfurase activity
S23_RS19265	COG2945	thiolester hydrolase activity
S23_RS19270	COG0625	glutathione transferase activity
S23_RS19275	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
S23_RS19280	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S23_RS19285	COG2271	Major facilitator Superfamily
S23_RS19290	COG2259	Doxx family
S23_RS19310	COG0739	heme binding
S23_RS19315	COG1309	transcriptional regulator
S23_RS19325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S23_RS19330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S23_RS19335	COG0753	catalase activity
S23_RS19350	COG0438	transferase activity, transferring glycosyl groups
S23_RS19380	COG2084	Dehydrogenase
S23_RS19390	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
S23_RS19400	COG1530	ribonuclease E activity
S23_RS19400	COG1530	ribonuclease E activity
S23_RS19425	COG1301	dicarboxylic acid transport
S23_RS19430	COG1268	BioY protein
S23_RS19435	COG0436	Aminotransferase
S23_RS19455	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
S23_RS19460	COG0511	ligase activity, forming carbon-carbon bonds
S23_RS19465	COG0439	Biotin carboxylase
S23_RS19475	COG0784	Response regulator, receiver
S23_RS19480	COG3920	Histidine kinase
S23_RS19485	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
S23_RS19495	COG0657	acetylesterase activity
S23_RS19510	COG2207	Transcriptional regulator
S23_RS19540	COG0784	Response regulator, receiver
S23_RS19540	COG4191	Histidine kinase
S23_RS19545	COG0697	spore germination
S23_RS19550	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S23_RS19605	COG0598	Magnesium transport protein CorA
S23_RS19615	COG2824	Alkylphosphonate utilization operon protein PhnA
S23_RS19645	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
S23_RS19670	COG1309	transcriptional regulator
S23_RS19695	COG1846	Transcriptional regulator
S23_RS19705	COG1376	ErfK ybiS ycfS ynhG family protein
S23_RS19735	COG4191	Histidine kinase
S23_RS19735	COG0784	Response regulator, receiver
S23_RS19745	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
S23_RS19750	COG2894	cell division
S23_RS19755	COG0850	regulation of cytokinetic process
S23_RS19765	COG1309	transcriptional regulator
S23_RS19770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S23_RS19800	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
S23_RS19830	COG2207	Transcriptional regulator
S23_RS19855	COG0657	acetylesterase activity
S23_RS19870	COG0488	(ABC) transporter
S23_RS19885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
S23_RS19890	COG1902	pentaerythritol trinitrate reductase activity
S23_RS19925	COG0174	glutamine synthetase
S23_RS19940	COG2365	Tyrosine phosphatase family
S23_RS19950	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS19975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S23_RS19985	COG3483	tryptophan 2,3-dioxygenase activity
S23_RS19995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S23_RS20025	COG3045	CreA protein
S23_RS20035	COG0386	Belongs to the glutathione peroxidase family
S23_RS20060	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
S23_RS20075	COG0280	phosphate acetyltransferase
S23_RS20075	COG0281	malic enzyme
S23_RS20085	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
S23_RS20090	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
S23_RS20105	COG1175	transmembrane transport
S23_RS20120	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
S23_RS20125	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S23_RS20135	COG2153	protein acetylation
S23_RS20155	COG1278	Cold shock
S23_RS20160	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
S23_RS20165	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
S23_RS20180	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
S23_RS20185	COG0248	Ppx GppA phosphatase
S23_RS20195	COG4774	siderophore transport
S23_RS20200	COG0861	Integral membrane protein TerC family
S23_RS20205	COG0105	UTP biosynthetic process
S23_RS20215	COG0488	(ABC) transporter
S23_RS20230	COG2226	methyltransferase
S23_RS20245	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
S23_RS20250	COG0795	lipopolysaccharide-transporting ATPase activity
S23_RS20260	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
S23_RS20270	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
S23_RS20275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
S23_RS20325	COG0194	GDP metabolic process
S23_RS20330	COG1561	YicC-like family, N-terminal region
S23_RS20335	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S23_RS20340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S23_RS20355	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
S23_RS20370	COG0360	Binds together with S18 to 16S ribosomal RNA
S23_RS20375	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
S23_RS20385	COG0359	binds to the 23S rRNA
S23_RS20415	COG0305	Participates in initiation and elongation during chromosome replication
S23_RS20420	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
S23_RS20440	COG2186	Transcriptional regulator
S23_RS20445	COG2084	Dehydrogenase
S23_RS20455	COG0765	amino acid transport
S23_RS20460	COG1126	abc transporter atp-binding protein
S23_RS20470	COG0698	ribose 5-phosphate isomerase
S23_RS20495	COG1286	toxin biosynthetic process
S23_RS20500	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
S23_RS20505	COG0300	oxidoreductase activity
S23_RS20520	COG1160	GTP binding
S23_RS20535	COG0318	PFAM AMP-dependent synthetase and ligase
S23_RS20560	COG0306	phosphate transporter
S23_RS20565	COG1392	Phosphate transport regulator
S23_RS20600	COG1393	Belongs to the ArsC family
S23_RS20605	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S23_RS20605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S23_RS20610	COG0625	glutathione transferase activity
S23_RS20640	COG0583	DNA-binding transcription factor activity
S23_RS20645	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS20695	COG0604	alcohol dehydrogenase
S23_RS20705	COG0583	DNA-binding transcription factor activity
S23_RS20710	COG0242	peptide deformylase activity
S23_RS20750	COG1864	DNA RNA non-specific endonuclease
S23_RS20750	COG3591	Belongs to the peptidase S1B family
S23_RS20755	COG0519	Catalyzes the synthesis of GMP from XMP
S23_RS20755	COG0518	GMP synthase (glutamine-hydrolyzing) activity
S23_RS20770	COG2814	Major facilitator Superfamily
S23_RS20780	COG1278	Cold shock
S23_RS20785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S23_RS20785	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
S23_RS20810	COG2130	NADP-dependent
S23_RS20825	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
S23_RS20845	COG1671	Belongs to the UPF0178 family
S23_RS20850	COG0488	(ABC) transporter
S23_RS20860	COG0493	'glutamate synthase
S23_RS20860	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
S23_RS20865	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS20875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S23_RS20890	COG1960	acyl-CoA dehydrogenase activity
S23_RS20915	COG1024	Enoyl-CoA hydratase
S23_RS20920	COG0183	Belongs to the thiolase family
S23_RS20925	COG2271	Major facilitator Superfamily
S23_RS20935	COG4964	Belongs to the GSP D family
S23_RS20960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S23_RS20985	COG2066	Belongs to the glutaminase family
S23_RS20985	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
S23_RS21005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S23_RS21010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
S23_RS21020	COG0183	Belongs to the thiolase family
S23_RS21025	COG0800	Aldolase
S23_RS21030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S23_RS21035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S23_RS21040	COG0395	ABC-type sugar transport system, permease component
S23_RS21045	COG1175	transmembrane transport
S23_RS21055	COG3842	ATPase activity
S23_RS21060	COG1609	Transcriptional regulator
S23_RS21065	COG0129	dihydroxy-acid dehydratase activity
S23_RS21070	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS21075	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS21085	COG0583	DNA-binding transcription factor activity
S23_RS21090	COG1994	Peptidase M50
S23_RS21105	COG0848	biopolymer transport protein
S23_RS21115	COG3128	pkhd-type hydroxylase
S23_RS21120	COG4774	siderophore transport
S23_RS21130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S23_RS21135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S23_RS21165	COG1137	ATPase activity
S23_RS21185	COG5507	3-demethylubiquinone-9 3-methyltransferase
S23_RS21215	COG0402	S-adenosylhomocysteine deaminase activity
S23_RS21220	COG0477	Major facilitator Superfamily
S23_RS21225	COG2267	carboxylic ester hydrolase activity
S23_RS21230	COG1802	Transcriptional regulator
S23_RS21235	COG1012	belongs to the aldehyde dehydrogenase family
S23_RS21240	COG2814	Major facilitator Superfamily
S23_RS21250	COG1309	transcriptional regulator
S23_RS21255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S23_RS21340	COG2072	flavoprotein involved in K transport
S23_RS21345	COG0318	PFAM AMP-dependent synthetase and ligase
S23_RS21380	COG1566	PFAM secretion protein HlyD family protein
S23_RS21390	COG1289	transmembrane transporter activity
S23_RS21420	COG1116	anion transmembrane transporter activity
S23_RS21465	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S23_RS21520	COG1846	Transcriptional regulator
S23_RS21560	COG2080	2 iron, 2 sulfur cluster binding
S23_RS21565	COG1529	Aldehyde oxidase and xanthine dehydrogenase
S23_RS21565	COG2010	Cytochrome c
S23_RS21605	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
S23_RS21630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S23_RS21635	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S23_RS21645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S23_RS21655	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
S23_RS21660	COG0436	Aminotransferase
S23_RS21670	COG3158	transport of potassium into the cell
S23_RS21675	COG3158	transport of potassium into the cell
S23_RS21685	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
S23_RS21700	COG1183	phosphatidylcholine synthase activity
S23_RS21705	COG0688	phosphatidylethanolamine metabolic process
S23_RS21710	COG5265	(ABC) transporter
S23_RS21725	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S23_RS21735	COG0215	cysteine-tRNA ligase activity
S23_RS21755	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
S23_RS21760	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
S23_RS21780	COG3585	molybdate ion transport
S23_RS21780	COG2005	Transcriptional regulator
S23_RS21790	COG0583	DNA-binding transcription factor activity
S23_RS21805	COG0861	Integral membrane protein TerC family
S23_RS21820	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S23_RS21820	COG1017	nitric oxide dioxygenase activity
S23_RS21830	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
S23_RS21835	COG0121	glutamine amidotransferase
S23_RS21840	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
S23_RS21880	COG3546	catalase activity
S23_RS21905	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
S23_RS21910	COG0546	phosphoglycolate phosphatase activity
S23_RS21920	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
S23_RS21925	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
S23_RS21935	COG5002	protein histidine kinase activity
S23_RS21940	COG0745	RESPONSE REGULATOR receiver
S23_RS21950	COG1309	transcriptional regulator
S23_RS21965	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
S23_RS21970	COG0489	protein tyrosine kinase activity
S23_RS21980	COG2084	Dehydrogenase
S23_RS21990	COG2202	Pas domain
S23_RS21990	COG2205	protein histidine kinase activity
S23_RS22040	COG5564	TIM-barrel signal transduction protein
S23_RS22045	COG2268	Band 7 protein
S23_RS22045	COG2268	Band 7 protein
S23_RS22090	COG3618	amidohydrolase
S23_RS22100	COG3386	PFAM SMP-30 Gluconolaconase
S23_RS22105	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S23_RS22115	COG1129	ABC transporter
S23_RS22125	COG4948	Mandelate Racemase Muconate Lactonizing
S23_RS22135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S23_RS22140	COG3842	ATPase activity
S23_RS22145	COG1063	alcohol dehydrogenase
S23_RS22160	COG1653	transport
S23_RS22170	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS22195	COG0829	nickel cation binding
S23_RS22200	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
S23_RS22205	COG0804	urea catabolic process
S23_RS22210	COG0832	Belongs to the urease beta subunit family
S23_RS22210	COG0831	urea catabolic process
S23_RS22215	COG0830	nickel cation binding
S23_RS22220	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
S23_RS22270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S23_RS22275	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
S23_RS22280	COG1349	DNA-binding transcription factor activity
S23_RS22305	COG0154	amidase activity
S23_RS22320	COG0300	oxidoreductase activity
S23_RS22325	COG0583	DNA-binding transcription factor activity
S23_RS22335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S23_RS22350	COG0647	UMP catabolic process
S23_RS22385	COG0450	alkyl hydroperoxide reductase
S23_RS22390	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S23_RS22395	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
S23_RS22400	COG0644	oxidoreductase
S23_RS22405	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
S23_RS22410	COG2086	electron transfer activity
S23_RS22455	COG3411	Ferredoxin
S23_RS22460	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
S23_RS22475	COG2151	metal-sulfur cluster biosynthetic enzyme
S23_RS22490	COG2346	COG2346, Truncated hemoglobins
S23_RS22510	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S23_RS22530	COG5554	nitrogen fixation
S23_RS22550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
S23_RS22565	COG5554	nitrogen fixation
S23_RS22570	COG1104	cysteine desulfurase activity
S23_RS22580	COG0316	Belongs to the HesB IscA family
S23_RS22615	COG5420	small protein containing a coiled-coil domain
S23_RS22630	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
S23_RS22635	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
S23_RS22640	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
S23_RS22660	COG2166	iron-sulfur cluster assembly
S23_RS22670	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S23_RS22680	COG0396	ATPase activity
S23_RS22685	COG0719	Fe-S assembly protein
S23_RS22690	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
S23_RS22695	COG3604	Transcriptional regulator
S23_RS22700	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS22710	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
S23_RS22725	COG1464	Belongs to the NlpA lipoprotein family
S23_RS22740	COG0445	tRNA wobble uridine modification
S23_RS22760	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS22780	COG1137	ATPase activity
S23_RS22785	COG0559	Belongs to the binding-protein-dependent transport system permease family
S23_RS22825	COG0402	S-adenosylhomocysteine deaminase activity
S23_RS22835	COG3485	protocatechuate 3,4-dioxygenase
S23_RS22840	COG0277	FAD linked oxidase domain protein
S23_RS22845	COG1129	ABC transporter
S23_RS22850	COG1172	Belongs to the binding-protein-dependent transport system permease family
S23_RS22855	COG1172	Belongs to the binding-protein-dependent transport system permease family
S23_RS22860	COG1879	ABC-type sugar transport system periplasmic component
S23_RS22870	COG4608	Belongs to the ABC transporter superfamily
S23_RS22875	COG0444	Belongs to the ABC transporter superfamily
S23_RS22880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S23_RS22885	COG0601	transmembrane transport
S23_RS22890	COG0747	negative chemotaxis
S23_RS22900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S23_RS22905	COG0601	transmembrane transport
S23_RS22910	COG0747	negative chemotaxis
S23_RS22915	COG2072	flavoprotein involved in K transport
S23_RS22920	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS22940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S23_RS22950	COG0318	PFAM AMP-dependent synthetase and ligase
S23_RS22955	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S23_RS22985	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
S23_RS22990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S23_RS23000	COG1802	Transcriptional regulator
S23_RS23010	COG0154	amidase activity
S23_RS23015	COG3842	ATPase activity
S23_RS23020	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
S23_RS23025	COG1176	ABC-type spermidine putrescine transport system, permease component I
S23_RS23035	COG2351	hydroxyisourate hydrolase activity
S23_RS23045	COG0154	amidase activity
S23_RS23065	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
S23_RS23080	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S23_RS23080	COG1648	precorrin-2 dehydrogenase activity
S23_RS23085	COG1797	cobyrinic acid a,c-diamide synthase activity
S23_RS23090	COG2875	Belongs to the precorrin methyltransferase family
S23_RS23105	COG2099	Precorrin-6x reductase
S23_RS23150	COG1492	cobalamin metabolic process
S23_RS23160	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
S23_RS23170	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
S23_RS23175	COG0778	Nitroreductase
S23_RS23210	COG0583	DNA-binding transcription factor activity
S23_RS23215	COG0346	lactoylglutathione lyase activity
S23_RS23220	COG0400	carboxylic ester hydrolase activity
S23_RS23245	COG0154	amidase activity
S23_RS23250	COG0747	negative chemotaxis
S23_RS23260	COG0444	Belongs to the ABC transporter superfamily
S23_RS23265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S23_RS23290	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS23320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S23_RS23330	COG0714	Associated with various cellular activities
S23_RS23335	COG3256	nitric oxide reductase
S23_RS23350	COG1845	cytochrome c oxidase, subunit III
S23_RS23355	COG4214	carbohydrate transport
S23_RS23365	COG4213	ABC transporter substrate-binding protein
S23_RS23370	COG3386	PFAM SMP-30 Gluconolaconase
S23_RS23390	COG1172	Belongs to the binding-protein-dependent transport system permease family
S23_RS23395	COG1172	Belongs to the binding-protein-dependent transport system permease family
S23_RS23400	COG1129	ABC transporter
S23_RS23405	COG1879	ABC-type sugar transport system periplasmic component
S23_RS23425	COG1053	succinate dehydrogenase
S23_RS23440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S23_RS23445	COG4521	taurine ABC transporter
S23_RS23450	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S23_RS23455	COG1116	anion transmembrane transporter activity
S23_RS23460	COG2855	membrane
S23_RS23470	COG0410	ABC transporter
S23_RS23500	COG1309	transcriptional regulator
S23_RS23505	COG2072	flavoprotein involved in K transport
S23_RS23515	COG1982	Orn Lys Arg decarboxylase major
S23_RS23530	COG2423	ornithine cyclodeaminase activity
S23_RS23535	COG1558	bacterial-type flagellum-dependent cell motility
S23_RS23540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S23_RS23565	COG2084	Dehydrogenase
S23_RS23570	COG3622	Belongs to the hyi family
S23_RS23575	COG3960	tartronate-semialdehyde synthase activity
S23_RS23580	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
S23_RS23615	COG1802	Transcriptional regulator
S23_RS23625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
S23_RS23645	COG1278	Cold shock
S23_RS23660	COG0443	Heat shock 70 kDa protein
S23_RS23680	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S23_RS23710	COG0604	alcohol dehydrogenase
S23_RS23710	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS23710	COG3321	synthase
S23_RS23715	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
S23_RS23720	COG2202	Pas domain
S23_RS23720	COG2205	protein histidine kinase activity
S23_RS23725	COG0583	DNA-binding transcription factor activity
S23_RS23740	COG3383	formate dehydrogenase (NAD+) activity
S23_RS23745	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
S23_RS23755	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
S23_RS23760	COG2205	protein histidine kinase activity
S23_RS23765	COG0745	RESPONSE REGULATOR receiver
S23_RS23780	COG3088	subunit of a heme lyase
S23_RS23785	COG1138	Cytochrome C-type biogenesis protein
S23_RS23790	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
S23_RS23795	COG4235	cytochrome complex assembly
S23_RS23820	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
S23_RS23840	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
S23_RS23845	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
S23_RS23850	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
S23_RS23865	COG0028	Belongs to the TPP enzyme family
S23_RS23870	COG0477	Major facilitator Superfamily
S23_RS23875	COG2983	Belongs to the UPF0260 family
S23_RS23895	COG1309	transcriptional regulator
S23_RS23900	COG0596	Alpha beta hydrolase
S23_RS23915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S23_RS23925	COG0071	Belongs to the small heat shock protein (HSP20) family
S23_RS23935	COG0459	protein refolding
S23_RS23940	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
S23_RS23975	COG0798	PFAM Bile acid sodium symporter
S23_RS23990	COG4774	siderophore transport
S23_RS24025	COG2205	protein histidine kinase activity
S23_RS24035	COG2166	iron-sulfur cluster assembly
S23_RS24040	COG4957	zinc ion binding
S23_RS24070	COG0433	COG0433 Predicted ATPase
S23_RS24085	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
S23_RS24095	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
S23_RS24135	COG1703	isobutyryl-CoA mutase activity
S23_RS24185	COG1529	Aldehyde oxidase and xanthine dehydrogenase
S23_RS24190	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
S23_RS24195	COG2080	2 iron, 2 sulfur cluster binding
S23_RS24215	COG1024	Enoyl-CoA hydratase
S23_RS24245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
S23_RS24255	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS24260	COG0587	DNA-directed DNA polymerase activity
S23_RS24280	COG1573	uracil-dna glycosylase
S23_RS24285	COG0306	phosphate transporter
S23_RS24290	COG1473	amidohydrolase
S23_RS24340	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
S23_RS24350	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
S23_RS24355	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
S23_RS24360	COG1657	PFAM Prenyltransferase squalene oxidase
S23_RS24365	COG1233	COG1233 Phytoene dehydrogenase and related
S23_RS24370	COG1562	ergosterol biosynthetic process
S23_RS24375	COG1562	ergosterol biosynthetic process
S23_RS24395	COG4302	ethanolamine ammonia-lyase activity
S23_RS24405	COG4303	Ethanolamine ammonia lyase large subunit
S23_RS24420	COG0784	Response regulator, receiver
S23_RS24420	COG4191	Histidine kinase
S23_RS24425	COG3920	Histidine kinase
S23_RS24440	COG2267	carboxylic ester hydrolase activity
S23_RS24465	COG3300	MHYT domain
S23_RS24465	COG5001	Diguanylate cyclase
S23_RS24470	COG1595	DNA-templated transcription, initiation
S23_RS24475	COG3806	Anti-sigma factor
S23_RS24480	COG1595	DNA-templated transcription, initiation
S23_RS24485	COG3046	protein related to deoxyribodipyrimidine photolyase
S23_RS24490	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
S23_RS24505	COG3842	ATPase activity
S23_RS24510	COG1175	transmembrane transport
S23_RS24515	COG0395	ABC-type sugar transport system, permease component
S23_RS24520	COG1653	transport
S23_RS24550	COG0840	transmembrane signaling receptor activity
S23_RS24555	COG2721	sulfolactate sulfo-lyase activity
S23_RS24575	COG0559	Belongs to the binding-protein-dependent transport system permease family
S23_RS24585	COG1846	Transcriptional regulator
S23_RS24590	COG3971	2-oxopent-4-enoate hydratase activity
S23_RS24610	COG0179	Fumarylacetoacetate (FAA) hydrolase
S23_RS24615	COG0028	Belongs to the TPP enzyme family
S23_RS24625	COG3145	DNA-N1-methyladenine dioxygenase activity
S23_RS24660	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS24665	COG3386	PFAM SMP-30 Gluconolaconase
S23_RS24670	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
S23_RS24675	COG0456	acetyltransferase
S23_RS24675	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
S23_RS24690	COG1024	Enoyl-CoA hydratase
S23_RS24700	COG1024	Enoyl-CoA hydratase
S23_RS24705	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS24715	COG1960	acyl-CoA dehydrogenase activity
S23_RS24720	COG1024	Enoyl-CoA hydratase
S23_RS24735	COG1024	Enoyl-CoA hydratase
S23_RS24740	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS24755	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S23_RS24760	COG0625	glutathione transferase activity
S23_RS24765	COG2070	2-Nitropropane dioxygenase
S23_RS24775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S23_RS24785	COG0840	transmembrane signaling receptor activity
S23_RS24790	COG0840	transmembrane signaling receptor activity
S23_RS24795	COG0840	transmembrane signaling receptor activity
S23_RS24800	COG0840	transmembrane signaling receptor activity
S23_RS24805	COG3395	kinase activity
S23_RS24810	COG3622	Belongs to the hyi family
S23_RS24815	COG2084	Dehydrogenase
S23_RS24820	COG0235	Class ii aldolase
S23_RS24840	COG0559	Belongs to the binding-protein-dependent transport system permease family
S23_RS24850	COG4336	lyase activity
S23_RS24855	COG0583	DNA-binding transcription factor activity
S23_RS24865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S23_RS24870	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
S23_RS24875	COG0473	3-isopropylmalate dehydrogenase activity
S23_RS24880	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS24890	COG0765	amino acid transport
S23_RS24895	COG4597	amino acid ABC transporter
S23_RS24905	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S23_RS24910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S23_RS24935	COG0477	Major facilitator Superfamily
S23_RS24940	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
S23_RS24975	COG2050	protein possibly involved in aromatic compounds catabolism
S23_RS24980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S23_RS24985	COG2151	metal-sulfur cluster biosynthetic enzyme
S23_RS24990	COG3396	Phenylacetate-CoA oxygenase
S23_RS24995	COG3460	Phenylacetate-CoA oxygenase
S23_RS25000	COG3396	Phenylacetate-CoA oxygenase
S23_RS25005	COG3327	negative regulation of DNA-templated transcription, initiation
S23_RS25010	COG0596	Alpha beta hydrolase
S23_RS25015	COG2733	membrane
S23_RS25025	COG0456	acetyltransferase
S23_RS25025	COG0454	-acetyltransferase
S23_RS25050	COG2124	cytochrome p450
S23_RS25050	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S23_RS25055	COG2267	carboxylic ester hydrolase activity
S23_RS25075	COG4166	transmembrane transport
S23_RS25080	COG0601	transmembrane transport
S23_RS25085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S23_RS25090	COG0444	Belongs to the ABC transporter superfamily
S23_RS25095	COG4608	Belongs to the ABC transporter superfamily
S23_RS25100	COG0405	Gamma-glutamyltransferase
S23_RS25105	COG0444	Belongs to the ABC transporter superfamily
S23_RS25110	COG4608	Belongs to the ABC transporter superfamily
S23_RS25115	COG0747	negative chemotaxis
S23_RS25120	COG0601	transmembrane transport
S23_RS25125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S23_RS25135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S23_RS25140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S23_RS25150	COG0028	Belongs to the TPP enzyme family
S23_RS25150	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
S23_RS25160	COG2124	cytochrome p450
S23_RS25175	COG0673	inositol 2-dehydrogenase activity
S23_RS25195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S23_RS25200	COG1309	transcriptional regulator
S23_RS25210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S23_RS25215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S23_RS25250	COG0129	dihydroxy-acid dehydratase activity
S23_RS25270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S23_RS25285	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
S23_RS25290	COG1522	sequence-specific DNA binding
S23_RS25300	COG1063	alcohol dehydrogenase
S23_RS25305	COG0697	spore germination
S23_RS25310	COG0656	L-ascorbic acid biosynthetic process
S23_RS25320	COG0243	molybdopterin cofactor binding
S23_RS25325	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S23_RS25330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S23_RS25330	COG1017	nitric oxide dioxygenase activity
S23_RS25335	COG1116	anion transmembrane transporter activity
S23_RS25340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S23_RS25345	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S23_RS25355	COG0515	serine threonine protein kinase
S23_RS25355	COG2815	serine threonine protein kinase
S23_RS25365	COG3485	protocatechuate 3,4-dioxygenase
S23_RS25385	COG3920	Histidine kinase
S23_RS25385	COG2202	Pas domain
S23_RS25400	COG0785	Cytochrome C biogenesis protein
S23_RS25415	COG1396	sequence-specific DNA binding
S23_RS25420	COG1024	Enoyl-CoA hydratase
S23_RS25430	COG0473	3-isopropylmalate dehydrogenase activity
S23_RS25445	COG0444	Belongs to the ABC transporter superfamily
S23_RS25450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S23_RS25470	COG0297	glycogen (starch) synthase activity
S23_RS25515	COG2217	Heavy metal translocating P-type atpase
S23_RS25530	COG2010	Cytochrome c
S23_RS25545	COG3278	Belongs to the heme-copper respiratory oxidase family
S23_RS25550	COG0516	GMP reductase activity
S23_RS25550	COG0517	IMP dehydrogenase activity
S23_RS25560	COG4191	Histidine kinase
S23_RS25565	COG4566	intracellular signal transduction
S23_RS25570	COG4566	intracellular signal transduction
S23_RS25575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S23_RS25595	COG1132	(ABC) transporter
S23_RS25600	COG0438	transferase activity, transferring glycosyl groups
S23_RS25605	COG2015	COG2015, Alkyl sulfatase and related hydrolases
S23_RS25620	COG4106	trans-aconitate 2-methyltransferase activity
S23_RS25640	COG0747	negative chemotaxis
S23_RS25655	COG0473	3-isopropylmalate dehydrogenase activity
S23_RS25660	COG2814	Major facilitator Superfamily
S23_RS25665	COG1032	radical SAM domain protein
S23_RS25680	COG0446	pyridine nucleotide-disulphide oxidoreductase
S23_RS25700	COG3258	Cytochrome c
S23_RS25710	COG1335	isochorismatase
S23_RS25720	COG1053	succinate dehydrogenase
S23_RS25725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S23_RS25745	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
S23_RS25755	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S23_RS25765	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS25840	COG2197	response regulator
S23_RS25850	COG4948	Mandelate Racemase Muconate Lactonizing
S23_RS25855	COG1473	amidohydrolase
S23_RS25860	COG1335	isochorismatase
S23_RS25875	COG3685	Protein conserved in bacteria
S23_RS25880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
S23_RS25915	COG0628	permease
S23_RS25930	COG1960	acyl-CoA dehydrogenase activity
S23_RS25945	COG1525	nuclease
S23_RS25945	COG0737	Belongs to the 5'-nucleotidase family
S23_RS25945	COG4085	toxin activity
S23_RS25950	COG0123	including yeast histone deacetylase and acetoin utilization protein
S23_RS25955	COG1722	exodeoxyribonuclease VII activity
S23_RS25960	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
S23_RS25970	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
S23_RS25975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S23_RS26000	COG0477	Major facilitator Superfamily
S23_RS26005	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S23_RS26010	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
S23_RS26020	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
S23_RS26030	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
S23_RS26055	COG0259	pyridoxamine-phosphate oxidase activity
S23_RS26060	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS26095	COG1960	acyl-CoA dehydrogenase activity
S23_RS26115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S23_RS26135	COG0656	L-ascorbic acid biosynthetic process
S23_RS26170	COG2814	Major facilitator Superfamily
S23_RS26190	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS26290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S23_RS26300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S23_RS26310	COG5001	Diguanylate cyclase
S23_RS26310	COG3300	MHYT domain
S23_RS26325	COG4451	ribulose bisphosphate carboxylase, small
S23_RS26330	COG1850	ribulose-bisphosphate carboxylase activity
S23_RS26350	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
S23_RS26375	COG2814	Major facilitator Superfamily
S23_RS26380	COG1309	transcriptional regulator
S23_RS26410	COG0009	L-threonylcarbamoyladenylate synthase
S23_RS26415	COG0277	FAD linked oxidase domain protein
S23_RS26440	COG1804	L-carnitine dehydratase bile acid-inducible protein F
S23_RS26445	COG2135	peptidase activity
S23_RS26470	COG2897	thiosulfate sulfurtransferase activity
S23_RS26475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S23_RS26480	COG0354	folic acid binding
S23_RS26485	COG0519	Catalyzes the synthesis of GMP from XMP
S23_RS26490	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
S23_RS26530	COG0604	alcohol dehydrogenase
S23_RS26540	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
S23_RS26545	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
S23_RS26560	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
S23_RS26560	COG0574	Belongs to the PEP-utilizing enzyme family
S23_RS26575	COG0751	glycine-tRNA ligase activity
S23_RS26580	COG0752	glycyl-tRNA synthetase alpha subunit
S23_RS26605	COG0142	geranyltranstransferase activity
S23_RS26615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S23_RS26625	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
S23_RS26640	COG1573	uracil-dna glycosylase
S23_RS26650	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
S23_RS26665	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
S23_RS26680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
S23_RS26680	COG0574	Belongs to the PEP-utilizing enzyme family
S23_RS26695	COG1846	Transcriptional regulator
S23_RS26695	COG0456	acetyltransferase
S23_RS26700	COG0521	Mo-molybdopterin cofactor biosynthetic process
S23_RS26705	COG2321	neutral zinc metallopeptidase
S23_RS26710	COG2189	Belongs to the N(4) N(6)-methyltransferase family
S23_RS26715	COG0625	glutathione transferase activity
S23_RS26720	COG0840	transmembrane signaling receptor activity
S23_RS26725	COG4251	negative regulation of phosphorylation
S23_RS26745	COG0625	glutathione transferase activity
S23_RS26760	COG3706	GGDEF domain
S23_RS26765	COG1194	a g-specific adenine glycosylase
S23_RS26785	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
S23_RS26785	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
S23_RS26790	COG1196	nuclear chromosome segregation
S23_RS26800	COG1704	LemA family
S23_RS26825	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S23_RS26840	COG2857	Cytochrome c1
S23_RS26840	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S23_RS26845	COG0723	plastoquinol--plastocyanin reductase activity
S23_RS26850	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
S23_RS26855	COG0602	queuosine metabolic process
S23_RS26865	COG0408	coproporphyrinogen oxidase activity
S23_RS26890	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
S23_RS26895	COG2943	transferase activity, transferring hexosyl groups
S23_RS26900	COG4591	ABC-type transport system involved in lipoprotein release permease component
S23_RS26920	COG3181	Tripartite tricarboxylate transporter family receptor
S23_RS26935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S23_RS26950	COG2863	cytochrome
S23_RS26995	COG0617	tRNA 3'-terminal CCA addition
S23_RS27015	COG0714	Associated with various cellular activities
S23_RS27040	COG4771	TonB-dependent receptor
S23_RS27050	COG0251	oxidation-reduction process
S23_RS27055	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS27060	COG0583	DNA-binding transcription factor activity
S23_RS27070	COG4166	transmembrane transport
S23_RS27090	COG0463	Glycosyl transferase, family 2
S23_RS27100	COG0494	nUDIX hydrolase
S23_RS27160	COG0501	Belongs to the peptidase M48B family
S23_RS27175	COG1902	pentaerythritol trinitrate reductase activity
S23_RS27190	COG0395	ABC-type sugar transport system, permease component
S23_RS27200	COG3842	ATPase activity
S23_RS27205	COG3842	ATPase activity
S23_RS27225	COG1349	DNA-binding transcription factor activity
S23_RS27245	COG1607	acyl-coa hydrolase
S23_RS27250	COG1250	3-hydroxyacyl-CoA dehydrogenase
S23_RS27250	COG1024	Enoyl-CoA hydratase
S23_RS27255	COG0183	Belongs to the thiolase family
S23_RS27270	COG1309	transcriptional regulator
S23_RS27290	COG3214	Protein conserved in bacteria
S23_RS27345	COG3237	CsbD-like
S23_RS27355	COG0405	Gamma-glutamyltransferase
S23_RS27360	COG1054	Belongs to the UPF0176 family
S23_RS27365	COG2900	Belongs to the SlyX family
S23_RS27370	COG2203	Gaf domain
S23_RS27370	COG4251	negative regulation of phosphorylation
S23_RS27370	COG5001	Diguanylate cyclase
S23_RS27370	COG3706	GGDEF domain
S23_RS27380	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
S23_RS27385	COG4566	intracellular signal transduction
S23_RS27390	COG0181	hydroxymethylbilane synthase activity
S23_RS27415	COG5001	Diguanylate cyclase
S23_RS27415	COG3300	MHYT domain
S23_RS27560	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S23_RS27565	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
S23_RS27565	COG0662	Cupin 2, conserved barrel domain protein
S23_RS27615	COG2244	polysaccharide biosynthetic process
S23_RS27620	COG1215	transferase activity, transferring glycosyl groups
S23_RS27655	COG2755	lipolytic protein G-D-S-L family
S23_RS27655	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
S23_RS27680	COG3206	protein involved in exopolysaccharide biosynthesis
S23_RS27680	COG0489	protein tyrosine kinase activity
S23_RS27690	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
S23_RS27700	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
S23_RS27735	COG2201	protein-glutamate methylesterase activity
S23_RS27745	COG0840	transmembrane signaling receptor activity
S23_RS27750	COG0835	chemotaxis
S23_RS27755	COG0840	transmembrane signaling receptor activity
S23_RS27760	COG0835	chemotaxis
S23_RS27765	COG2198	Histidine kinase
S23_RS27765	COG0643	Histidine kinase
S23_RS27770	COG0745	RESPONSE REGULATOR receiver
S23_RS27790	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
S23_RS27820	COG3485	protocatechuate 3,4-dioxygenase
S23_RS27825	COG3485	protocatechuate 3,4-dioxygenase
S23_RS27830	COG0583	DNA-binding transcription factor activity
S23_RS27835	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
S23_RS27840	COG3447	MASE1 domain protein
S23_RS27840	COG5002	protein histidine kinase activity
S23_RS27840	COG5001	Diguanylate cyclase
S23_RS27845	COG1309	transcriptional regulator
S23_RS27865	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
S23_RS27880	COG3976	FMN-binding domain protein
S23_RS27880	COG1053	succinate dehydrogenase
S23_RS27890	COG1414	Transcriptional regulator
S23_RS27895	COG2084	Dehydrogenase
S23_RS27915	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
S23_RS27920	COG3383	formate dehydrogenase (NAD+) activity
S23_RS27925	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
S23_RS27935	COG2223	nitrite transmembrane transporter activity
S23_RS27950	COG1763	Mo-molybdopterin cofactor biosynthetic process
S23_RS27960	COG0746	molybdenum cofactor guanylyltransferase activity
S23_RS27970	COG0303	'Molybdopterin
S23_RS28040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S23_RS28040	COG1017	nitric oxide dioxygenase activity
S23_RS28125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S23_RS28140	COG2226	methyltransferase
S23_RS28150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
S23_RS28155	COG0683	leucine binding
S23_RS28165	COG0411	ABC transporter
S23_RS28185	COG3239	Fatty acid desaturase
S23_RS28225	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
S23_RS28245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S23_RS28270	COG1024	Enoyl-CoA hydratase
S23_RS28275	COG0405	Gamma-glutamyltransferase
S23_RS28280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S23_RS28285	COG1126	abc transporter atp-binding protein
S23_RS28290	COG0765	amino acid transport
S23_RS28295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S23_RS28305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S23_RS28310	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S23_RS28320	COG1529	Aldehyde oxidase and xanthine dehydrogenase
S23_RS28325	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
S23_RS28330	COG2080	2 iron, 2 sulfur cluster binding
S23_RS28335	COG1309	transcriptional regulator
S23_RS28380	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
S23_RS28405	COG1595	DNA-templated transcription, initiation
S23_RS28425	COG3766	membrane
S23_RS28435	COG0754	glutathionylspermidine amidase activity
S23_RS28445	COG2201	protein-glutamate methylesterase activity
S23_RS28450	COG0784	Response regulator, receiver
S23_RS28450	COG0643	Histidine kinase
S23_RS28450	COG2198	Histidine kinase
S23_RS28455	COG0835	chemotaxis
S23_RS28460	COG2198	Histidine kinase
S23_RS28460	COG0643	Histidine kinase
S23_RS28460	COG0784	Response regulator, receiver
S23_RS28500	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S23_RS28530	COG2207	Transcriptional regulator
S23_RS28555	COG1376	ErfK ybiS ycfS ynhG family protein
S23_RS28565	COG0028	Belongs to the TPP enzyme family
S23_RS28570	COG1376	ErfK ybiS ycfS ynhG family protein
S23_RS28585	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
S23_RS28605	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
S23_RS28610	COG0501	Belongs to the peptidase M48B family
S23_RS28630	COG0583	DNA-binding transcription factor activity
S23_RS28635	COG1960	acyl-CoA dehydrogenase activity
S23_RS28645	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
S23_RS28655	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS28665	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS28670	COG1272	protein, Hemolysin III
S23_RS28675	COG3106	COG3106 Predicted ATPase
S23_RS28680	COG3768	UPF0283 membrane protein
S23_RS28705	COG1278	Cold shock
S23_RS28750	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
S23_RS28755	COG1704	LemA family
S23_RS28760	COG1024	Enoyl-CoA hydratase
S23_RS28770	COG1960	acyl-CoA dehydrogenase activity
S23_RS28780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S23_RS28790	COG2514	catechol 2,3-dioxygenase activity
S23_RS28795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S23_RS28835	COG0028	Belongs to the TPP enzyme family
S23_RS28840	COG0800	Aldolase
S23_RS28845	COG3734	2-keto-3-deoxy-galactonokinase
S23_RS28855	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S23_RS28860	COG3284	Transcriptional regulator
S23_RS28865	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
S23_RS28880	COG3842	ATPase activity
S23_RS28885	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
S23_RS28890	COG1176	ABC-type spermidine putrescine transport system, permease component I
S23_RS28915	COG1309	transcriptional regulator
S23_RS28930	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S23_RS28955	COG0564	pseudouridine synthase activity
S23_RS28960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
S23_RS28985	COG3706	GGDEF domain
S23_RS28995	COG1280	lysine exporter protein (LysE YggA)
S23_RS29035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
S23_RS29040	COG0358	DNA primase activity
S23_RS29075	COG1280	lysine exporter protein (LysE YggA)
S23_RS29080	COG0640	Transcriptional regulator
S23_RS29120	COG1846	Transcriptional regulator
S23_RS29125	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S23_RS29130	COG0596	Alpha beta hydrolase
S23_RS29145	COG0505	Belongs to the CarA family
S23_RS29180	COG2814	Major facilitator Superfamily
S23_RS29185	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S23_RS29190	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S23_RS29195	COG1522	sequence-specific DNA binding
S23_RS29205	COG0583	DNA-binding transcription factor activity
S23_RS29210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S23_RS29230	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
S23_RS29280	COG2205	protein histidine kinase activity
S23_RS29285	COG0628	permease
S23_RS29290	COG0840	transmembrane signaling receptor activity
S23_RS29310	COG0183	Belongs to the thiolase family
S23_RS29315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S23_RS29335	COG0625	glutathione transferase activity
S23_RS29350	COG2223	nitrite transmembrane transporter activity
S23_RS29355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S23_RS29360	COG1304	FMN binding
S23_RS29375	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
S23_RS29385	COG0659	secondary active sulfate transmembrane transporter activity
S23_RS29395	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
S23_RS29405	COG0436	Aminotransferase
S23_RS29410	COG0625	glutathione transferase activity
S23_RS29425	COG0667	Aldo Keto reductase
S23_RS29470	COG0583	DNA-binding transcription factor activity
S23_RS29485	COG0556	nucleotide-excision repair
S23_RS29540	COG2030	dehydratase
S23_RS29550	COG0012	GTP binding
S23_RS29555	COG0193	aminoacyl-tRNA hydrolase activity
S23_RS29560	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
S23_RS29575	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
S23_RS29585	COG1496	oxidoreductase activity
S23_RS29595	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
S23_RS29605	COG1181	Belongs to the D-alanine--D-alanine ligase family
S23_RS29615	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
S23_RS29615	COG3608	succinylglutamate desuccinylase aspartoacylase
S23_RS29625	COG0542	response to heat
S23_RS29650	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
S23_RS29660	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S23_RS29670	COG1942	4-Oxalocrotonate Tautomerase
S23_RS29675	COG0124	histidyl-tRNA synthetase
S23_RS29690	COG1846	Transcriptional regulator
S23_RS29695	COG0745	RESPONSE REGULATOR receiver
S23_RS29725	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
S23_RS29730	COG1278	Cold shock
S23_RS29735	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
S23_RS29740	COG0322	excinuclease ABC activity
S23_RS29745	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
S23_RS29755	COG0314	molybdopterin synthase activity
S23_RS29760	COG2890	protein-(glutamine-N5) methyltransferase activity
S23_RS29770	COG1295	ribonuclease BN
S23_RS29785	COG5001	Diguanylate cyclase
S23_RS29795	COG0745	RESPONSE REGULATOR receiver
S23_RS29800	COG0196	riboflavin kinase activity
S23_RS29805	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
S23_RS29820	COG0612	Peptidase, M16
S23_RS29825	COG0612	Peptidase, M16
S23_RS29860	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
S23_RS29865	COG0742	ribosomal rna small subunit methyltransferase
S23_RS29870	COG1187	pseudouridine synthase activity
S23_RS29875	COG0590	tRNA wobble adenosine to inosine editing
S23_RS29880	COG0596	Alpha beta hydrolase
S23_RS29885	COG0151	Belongs to the GarS family
S23_RS29920	COG1570	exodeoxyribonuclease VII activity
S23_RS29935	COG1663	tetraacyldisaccharide 4'-kinase activity
S23_RS29940	COG1519	Transferase
S23_RS29960	COG0312	modulator of DNA gyrase
S23_RS30000	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
S23_RS30005	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
S23_RS30010	COG0463	Glycosyl transferase, family 2
S23_RS30020	COG3416	Protein conserved in bacteria
S23_RS30035	COG1376	ErfK ybiS ycfS ynhG family protein
S23_RS30035	COG1388	LysM domain
S23_RS30050	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
S23_RS30055	COG0459	protein refolding
S23_RS30070	COG1620	l-lactate permease
S23_RS30075	COG4178	(ABC) transporter
S23_RS30090	COG0247	lactate metabolic process
S23_RS30095	COG0277	FAD linked oxidase domain protein
S23_RS30100	COG0277	FAD linked oxidase domain protein
S23_RS30105	COG3474	cytochrome
S23_RS30130	COG0257	Belongs to the bacterial ribosomal protein bL36 family
S23_RS30150	COG0604	alcohol dehydrogenase
S23_RS30160	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
S23_RS30180	COG0583	DNA-binding transcription factor activity
S23_RS30185	COG1741	Belongs to the pirin family
S23_RS30190	COG0655	NAD(P)H dehydrogenase (quinone) activity
S23_RS30195	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
S23_RS30215	COG1215	transferase activity, transferring glycosyl groups
S23_RS30235	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
S23_RS30240	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S23_RS30250	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
S23_RS30295	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S23_RS30305	COG1126	abc transporter atp-binding protein
S23_RS30310	COG0765	amino acid transport
S23_RS30315	COG0765	amino acid transport
S23_RS30345	COG1902	pentaerythritol trinitrate reductase activity
S23_RS30355	COG1012	belongs to the aldehyde dehydrogenase family
S23_RS30385	COG0747	negative chemotaxis
S23_RS30390	COG1472	Belongs to the glycosyl hydrolase 3 family
S23_RS30400	COG0745	RESPONSE REGULATOR receiver
S23_RS30405	COG2205	protein histidine kinase activity
S23_RS30525	COG3206	protein involved in exopolysaccharide biosynthesis
S23_RS30525	COG0489	protein tyrosine kinase activity
S23_RS30555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S23_RS30575	COG0438	transferase activity, transferring glycosyl groups
S23_RS30595	COG0463	Glycosyl transferase, family 2
S23_RS30680	COG0483	inositol monophosphate 1-phosphatase activity
S23_RS30690	COG0583	DNA-binding transcription factor activity
S23_RS30705	COG1280	lysine exporter protein (LysE YggA)
S23_RS30715	COG2010	Cytochrome c
S23_RS30725	COG0071	Belongs to the small heat shock protein (HSP20) family
S23_RS30740	COG0070	glutamate synthase
S23_RS30740	COG0069	glutamate synthase activity
S23_RS30740	COG0067	glutamate synthase
S23_RS30775	COG0330	HflC and HflK could
S23_RS30780	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
S23_RS30795	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
S23_RS30825	COG0251	oxidation-reduction process
S23_RS30850	COG0523	cobalamin synthesis protein
S23_RS30855	COG0803	Belongs to the bacterial solute-binding protein 9 family
S23_RS30865	COG1121	(ABC) transporter
S23_RS30885	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
S23_RS30935	COG0318	PFAM AMP-dependent synthetase and ligase
S23_RS30960	COG0326	Molecular chaperone. Has ATPase activity
S23_RS30975	COG0784	Response regulator, receiver
S23_RS30990	COG0778	Nitroreductase
S23_RS30995	COG1960	acyl-CoA dehydrogenase activity
S23_RS31000	COG1960	acyl-CoA dehydrogenase activity
S23_RS31005	COG1960	acyl-CoA dehydrogenase activity
S23_RS31010	COG0318	PFAM AMP-dependent synthetase and ligase
S23_RS31030	COG0183	Belongs to the thiolase family
S23_RS31035	COG0318	PFAM AMP-dependent synthetase and ligase
S23_RS31045	COG2267	carboxylic ester hydrolase activity
S23_RS31060	COG5285	phytanoyl-CoA dioxygenase
S23_RS31075	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
S23_RS31080	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
S23_RS31120	COG0739	heme binding
S23_RS31125	COG0542	response to heat
S23_RS31145	COG2813	Specifically methylates the guanine in position
S23_RS31145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
S23_RS31150	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
S23_RS31160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
S23_RS31165	COG0287	Prephenate dehydrogenase
S23_RS31195	COG2884	Cell division ATP-binding protein ftsE
S23_RS31205	COG2204	response regulator
S23_RS31220	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S23_RS31230	COG0019	diaminopimelate decarboxylase activity
S23_RS31240	COG0165	Argininosuccinate lyase
S23_RS31245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S23_RS31255	COG1250	3-hydroxyacyl-CoA dehydrogenase
S23_RS31260	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
S23_RS31265	COG2086	electron transfer activity
S23_RS31290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S23_RS31315	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
S23_RS31315	COG2273	Hydrolase Family 16
S23_RS31325	COG3360	Dodecin
S23_RS31345	COG4608	Belongs to the ABC transporter superfamily
S23_RS31350	COG0444	Belongs to the ABC transporter superfamily
S23_RS31355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S23_RS31360	COG0601	transmembrane transport
S23_RS31370	COG1473	amidohydrolase
S23_RS31375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S23_RS31390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
S23_RS31390	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
S23_RS31425	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
S23_RS31435	COG0546	phosphoglycolate phosphatase activity
S23_RS31435	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
S23_RS31455	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
S23_RS31485	COG2197	response regulator
S23_RS31490	COG4585	Histidine kinase
S23_RS31525	COG2070	2-Nitropropane dioxygenase
S23_RS31530	COG0318	PFAM AMP-dependent synthetase and ligase
S23_RS31535	COG0784	Response regulator, receiver
S23_RS31535	COG4191	Histidine kinase
S23_RS31540	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
S23_RS31555	COG1027	Aspartate ammonia-lyase
S23_RS31565	COG1238	metal cluster binding
S23_RS31570	COG0140	phosphoribosyl-ATP diphosphatase activity
S23_RS31585	COG1132	(ABC) transporter
S23_RS31590	COG1686	Belongs to the peptidase S11 family
S23_RS31595	COG0318	PFAM AMP-dependent synthetase and ligase
S23_RS31605	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
S23_RS31605	COG0678	peroxiredoxin activity
S23_RS31610	COG0328	RNA-DNA hybrid ribonuclease activity
S23_RS31615	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S23_RS31620	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
S23_RS31630	COG3047	cAMP biosynthetic process
S23_RS31665	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS31680	COG2358	TRAP transporter, solute receptor (TAXI family
S23_RS31710	COG0667	Aldo Keto reductase
S23_RS31725	COG4716	Myosin-crossreactive antigen
S23_RS31730	COG1022	Amp-dependent synthetase and ligase
S23_RS31735	COG1335	isochorismatase
S23_RS31760	COG0784	Response regulator, receiver
S23_RS31760	COG4191	Histidine kinase
S23_RS31785	COG0583	DNA-binding transcription factor activity
S23_RS31795	COG1116	anion transmembrane transporter activity
S23_RS31800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S23_RS31805	COG0243	molybdopterin cofactor binding
S23_RS31830	COG3321	synthase
S23_RS31830	COG4221	oxidoreductase activity
S23_RS31830	COG0604	alcohol dehydrogenase
S23_RS31830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S23_RS31845	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
S23_RS31850	COG0424	maF-like protein
S23_RS31855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S23_RS31860	COG5328	Belongs to the UPF0262 family
S23_RS31865	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
S23_RS31875	COG0702	epimerase
S23_RS31905	COG0492	ferredoxin-NADP+ reductase activity
S23_RS31930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S23_RS31940	COG4948	Mandelate Racemase Muconate Lactonizing
S23_RS31945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S23_RS31965	COG3971	2-oxopent-4-enoate hydratase activity
S23_RS31970	COG0179	Fumarylacetoacetate (FAA) hydrolase
S23_RS31975	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S23_RS31995	COG2267	carboxylic ester hydrolase activity
S23_RS32000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S23_RS32025	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
S23_RS32030	COG3454	Phosphonate metabolism
S23_RS32035	COG4778	phosphonate C-P lyase system protein PhnL
S23_RS32040	COG4107	phosphonate C-P lyase system protein PhnK
S23_RS32045	COG3627	carbon phosphorus lyase activity
S23_RS32050	COG3626	phosphonate metabolism
S23_RS32055	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
S23_RS32060	COG3624	Phosphonate C-P lyase system protein PhnG
S23_RS32065	COG2188	Transcriptional regulator
S23_RS32070	COG3639	organic phosphonate transmembrane transporter activity
S23_RS32075	COG3639	organic phosphonate transmembrane transporter activity
S23_RS32085	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
S23_RS32095	COG3454	Phosphonate metabolism
S23_RS32100	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
S23_RS32115	COG1024	Enoyl-CoA hydratase
S23_RS32125	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
S23_RS32130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S23_RS32150	COG4774	siderophore transport
S23_RS32155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S23_RS32160	COG0277	FAD linked oxidase domain protein
S23_RS32165	COG1802	Transcriptional regulator
S23_RS32175	COG1032	radical SAM domain protein
S23_RS32185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S23_RS32190	COG1116	anion transmembrane transporter activity
S23_RS32210	COG1959	2 iron, 2 sulfur cluster binding
S23_RS32230	COG0583	DNA-binding transcription factor activity
S23_RS32235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S23_RS32275	COG1024	Enoyl-CoA hydratase
S23_RS32295	COG3038	cytochrome b561
S23_RS32305	COG3852	Histidine kinase
S23_RS32310	COG0594	ribonuclease P activity
S23_RS32315	COG0706	membrane insertase activity
S23_RS32320	COG0218	Necessary for normal cell division and for the maintenance of normal septation
S23_RS32330	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
S23_RS32345	COG2171	N-acyltransferase activity
S23_RS32355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S23_RS32365	COG0101	tRNA pseudouridine synthase activity
S23_RS32370	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
S23_RS32375	COG0242	peptide deformylase activity
S23_RS32385	COG2223	nitrite transmembrane transporter activity
S23_RS32395	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
S23_RS32400	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
S23_RS32405	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
S23_RS32410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S23_RS32415	COG0765	amino acid transport
S23_RS32420	COG1126	abc transporter atp-binding protein
S23_RS32445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S23_RS32450	COG1522	sequence-specific DNA binding
S23_RS32455	COG2205	protein histidine kinase activity
S23_RS32480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S23_RS32485	COG3577	Aspartyl protease
S23_RS32490	COG1643	Atp-dependent helicase
S23_RS32495	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S23_RS32510	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S23_RS32510	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S23_RS32515	COG1280	lysine exporter protein (LysE YggA)
S23_RS32520	COG0625	glutathione transferase activity
S23_RS32525	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
S23_RS32545	COG1201	RNA secondary structure unwinding
S23_RS32580	COG0167	dihydroorotate dehydrogenase activity
S23_RS32600	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
S23_RS32610	COG1999	signal sequence binding
S23_RS32630	COG0251	oxidation-reduction process
S23_RS32655	COG1172	Belongs to the binding-protein-dependent transport system permease family
S23_RS32660	COG1129	ABC transporter
S23_RS32665	COG2115	Belongs to the xylose isomerase family
S23_RS32670	COG1070	Carbohydrate kinase
S23_RS32675	COG1609	Transcriptional regulator
S23_RS32685	COG1396	sequence-specific DNA binding
S23_RS32695	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S23_RS32735	COG0717	Belongs to the dCTP deaminase family
S23_RS32760	COG2967	ApaG domain
S23_RS32770	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
S23_RS32775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S23_RS32785	COG0745	RESPONSE REGULATOR receiver
S23_RS32790	COG0704	Plays a role in the regulation of phosphate uptake
S23_RS32795	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S23_RS32800	COG0581	inorganic phosphate transmembrane transporter activity
S23_RS32805	COG0573	inorganic phosphate transmembrane transporter activity
S23_RS32810	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
S23_RS32815	COG5002	protein histidine kinase activity
S23_RS32865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S23_RS32870	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
S23_RS32880	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
S23_RS32880	COG4651	solute:proton antiporter activity
S23_RS32885	COG1414	Transcriptional regulator
S23_RS32890	COG4638	Rieske (2fe-2S)
S23_RS32910	COG4214	carbohydrate transport
S23_RS32925	COG3916	Acyl-homoserine-lactone synthase
S23_RS32930	COG2197	response regulator
S23_RS32935	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
S23_RS32945	COG1252	NADH dehydrogenase
S23_RS32955	COG2124	cytochrome p450
S23_RS32965	COG0318	PFAM AMP-dependent synthetase and ligase
S23_RS32980	COG1802	Transcriptional regulator
S23_RS33000	COG4172	Belongs to the ABC transporter superfamily
S23_RS33005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S23_RS33010	COG0601	transmembrane transport
S23_RS33015	COG0747	negative chemotaxis
S23_RS33030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S23_RS33030	COG4191	Histidine kinase
S23_RS33035	COG0784	Response regulator, receiver
S23_RS33035	COG3437	response regulator, receiver
S23_RS33045	COG1595	DNA-templated transcription, initiation
S23_RS33060	COG1271	oxidase subunit
S23_RS33065	COG1294	oxidase, subunit
S23_RS33080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S23_RS33085	COG1960	acyl-CoA dehydrogenase activity
S23_RS33090	COG1960	acyl-CoA dehydrogenase activity
S23_RS33100	COG2514	catechol 2,3-dioxygenase activity
S23_RS33110	COG2814	Major facilitator Superfamily
S23_RS33115	COG1505	serine-type exopeptidase activity
S23_RS33150	COG0737	Belongs to the 5'-nucleotidase family
S23_RS33160	COG2271	Major facilitator Superfamily
S23_RS33190	COG3788	relative of glutathione S-transferase, MAPEG superfamily
S23_RS33195	COG0683	leucine binding
S23_RS33205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S23_RS33225	COG0601	transmembrane transport
S23_RS33230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S23_RS33235	COG0444	Belongs to the ABC transporter superfamily
S23_RS33240	COG4608	Belongs to the ABC transporter superfamily
S23_RS33250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S23_RS33255	COG3246	L-lysine catabolic process to acetate
S23_RS33270	COG1960	acyl-CoA dehydrogenase activity
S23_RS33275	COG1960	acyl-CoA dehydrogenase activity
S23_RS33335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S23_RS33355	COG1129	ABC transporter
S23_RS33375	COG0784	Response regulator, receiver
S23_RS33375	COG5002	protein histidine kinase activity
S23_RS33375	COG2198	Histidine kinase
S23_RS33380	COG0745	RESPONSE REGULATOR receiver
S23_RS33385	COG2072	flavoprotein involved in K transport
S23_RS33400	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
S23_RS33405	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
S23_RS33410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S23_RS33420	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
S23_RS33430	COG3300	MHYT domain
S23_RS33430	COG5001	Diguanylate cyclase
S23_RS33450	COG3300	MHYT domain
S23_RS33450	COG5001	Diguanylate cyclase
S23_RS33465	COG0333	Belongs to the bacterial ribosomal protein bL32 family
S23_RS33470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S23_RS33475	COG0142	geranyltranstransferase activity
S23_RS33505	COG0025	NhaP-type Na H and K H
S23_RS33515	COG2175	clavaminate synthase activity
S23_RS33520	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
S23_RS33530	COG0735	belongs to the Fur family
S23_RS33540	COG1566	PFAM secretion protein HlyD family protein
S23_RS33560	COG3485	protocatechuate 3,4-dioxygenase
S23_RS33565	COG3485	protocatechuate 3,4-dioxygenase
S23_RS33570	COG0183	Belongs to the thiolase family
S23_RS33575	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
S23_RS33600	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
S23_RS33630	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
S23_RS33650	COG1131	(ABC) transporter
S23_RS33660	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
S23_RS33675	COG0366	Alpha amylase catalytic
S23_RS33680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S23_RS33700	COG1028	Short-chain dehydrogenase reductase Sdr
S23_RS33710	COG5001	Diguanylate cyclase
S23_RS33715	COG3829	transcription factor binding
S23_RS33715	COG3290	protein histidine kinase activity
S23_RS33745	COG5001	Diguanylate cyclase
S23_RS33750	COG3706	GGDEF domain
S23_RS33765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S23_RS33800	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
S23_RS33815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S23_RS33870	COG0412	Dienelactone hydrolase
S23_RS33880	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S23_RS33890	COG0268	Binds directly to 16S ribosomal RNA
S23_RS33940	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
S23_RS33940	COG2755	lipolytic protein G-D-S-L family
S23_RS33945	COG5001	Diguanylate cyclase
S23_RS33950	COG0681	Belongs to the peptidase S26 family
S23_RS33995	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
S23_RS34080	COG5487	UPF0391 membrane protein
S23_RS34165	COG3813	Protein conserved in bacteria
S23_RS34185	COG0720	synthase
S23_RS34200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S23_RS34295	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
S23_RS34305	COG0583	DNA-binding transcription factor activity
S23_RS34330	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
S23_RS34355	COG0596	Alpha beta hydrolase
S23_RS34485	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
S23_RS34740	COG0230	Belongs to the bacterial ribosomal protein bL34 family
S23_RS35535	COG4297	protein containing double-stranded beta helix domain
S23_RS36010	COG1618	nucleotide phosphatase activity, acting on free nucleotides
S23_RS36010	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system