locus-tag	class	description
H7K75_RS00025	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H7K75_RS00025	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7K75_RS00050	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7K75_RS00085	COG2010	Cytochrome c
H7K75_RS00110	COG4716	Myosin-crossreactive antigen
H7K75_RS00150	COG2963	transposase activity
H7K75_RS00155	COG3436	PFAM IS66 Orf2 family protein
H7K75_RS00160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K75_RS00165	COG0765	amino acid transport
H7K75_RS00170	COG1396	sequence-specific DNA binding
H7K75_RS00225	COG1192	Involved in chromosome partitioning
H7K75_RS00265	COG5489	Protein of unknown function (DUF736)
H7K75_RS00275	COG1278	Cold shock
H7K75_RS00280	COG2226	methyltransferase
H7K75_RS00325	COG2925	Exonuclease
H7K75_RS00375	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H7K75_RS00380	COG2003	Belongs to the UPF0758 family
H7K75_RS00415	COG4941	Belongs to the sigma-70 factor family
H7K75_RS00430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7K75_RS00435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K75_RS00465	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H7K75_RS00475	COG1253	flavin adenine dinucleotide binding
H7K75_RS00485	COG0069	glutamate synthase activity
H7K75_RS00500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K75_RS00505	COG1301	dicarboxylic acid transport
H7K75_RS00510	COG2130	NADP-dependent
H7K75_RS00565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7K75_RS00570	COG0583	DNA-binding transcription factor activity
H7K75_RS00580	COG1024	Enoyl-CoA hydratase
H7K75_RS00595	COG1960	acyl-CoA dehydrogenase activity
H7K75_RS00615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7K75_RS00620	COG3964	amidohydrolase
H7K75_RS00650	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7K75_RS00675	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H7K75_RS00685	COG2261	transglycosylase associated protein
H7K75_RS00700	COG1960	acyl-CoA dehydrogenase activity
H7K75_RS00720	COG1024	Enoyl-CoA hydratase
H7K75_RS00740	COG0477	Major facilitator Superfamily
H7K75_RS00745	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H7K75_RS00750	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7K75_RS00760	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H7K75_RS00775	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H7K75_RS00805	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H7K75_RS00810	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H7K75_RS00825	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H7K75_RS00845	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H7K75_RS00890	COG1902	pentaerythritol trinitrate reductase activity
H7K75_RS00920	COG0586	Pfam SNARE associated Golgi protein
H7K75_RS00925	COG0372	Belongs to the citrate synthase family
H7K75_RS00930	COG0372	Belongs to the citrate synthase family
H7K75_RS00945	COG4536	flavin adenine dinucleotide binding
H7K75_RS00950	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H7K75_RS00955	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H7K75_RS00965	COG4974	Belongs to the 'phage' integrase family
H7K75_RS00970	COG0825	malonyl-CoA metabolic process
H7K75_RS00975	COG3034	peptidoglycan biosynthetic process
H7K75_RS00985	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H7K75_RS01015	COG1846	Transcriptional regulator
H7K75_RS01035	COG0653	protein targeting
H7K75_RS01040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7K75_RS01045	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H7K75_RS01060	COG1040	competence protein
H7K75_RS01065	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H7K75_RS01070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7K75_RS01085	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7K75_RS01095	COG0527	aspartate kinase activity
H7K75_RS01100	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
H7K75_RS01105	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H7K75_RS01110	COG2890	protein-(glutamine-N5) methyltransferase activity
H7K75_RS01125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7K75_RS01135	COG0697	spore germination
H7K75_RS01150	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
H7K75_RS01165	COG0657	acetylesterase activity
H7K75_RS01200	COG0583	DNA-binding transcription factor activity
H7K75_RS01205	COG2072	flavoprotein involved in K transport
H7K75_RS01215	COG1522	sequence-specific DNA binding
H7K75_RS01220	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H7K75_RS01225	COG0514	ATP-dependent DNA helicase (RecQ)
H7K75_RS01240	COG2873	o-acetylhomoserine
H7K75_RS01245	COG0154	amidase activity
H7K75_RS01255	COG1228	amidohydrolase
H7K75_RS01260	COG0667	Aldo Keto reductase
H7K75_RS01265	COG2814	Major facilitator Superfamily
H7K75_RS01270	COG0583	DNA-binding transcription factor activity
H7K75_RS01275	COG3257	ureidoglycine aminohydrolase activity
H7K75_RS01295	COG4191	Histidine kinase
H7K75_RS01300	COG4566	intracellular signal transduction
H7K75_RS01310	COG1289	transmembrane transporter activity
H7K75_RS01320	COG1566	PFAM secretion protein HlyD family protein
H7K75_RS01325	COG2169	Transcriptional regulator
H7K75_RS01340	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
H7K75_RS01360	COG3052	prosthetic group binding
H7K75_RS01395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K75_RS01405	COG4191	Histidine kinase
H7K75_RS01410	COG0243	molybdopterin cofactor binding
H7K75_RS01415	COG2140	Oxalate decarboxylase
H7K75_RS01420	COG1294	oxidase, subunit
H7K75_RS01425	COG1271	oxidase subunit
H7K75_RS01430	COG0579	oxidoreductase
H7K75_RS01440	COG0114	fumarate hydratase activity
H7K75_RS01450	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H7K75_RS01475	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS01520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K75_RS01525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K75_RS01530	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7K75_RS01570	COG0601	transmembrane transport
H7K75_RS01580	COG0444	Belongs to the ABC transporter superfamily
H7K75_RS01585	COG4608	Belongs to the ABC transporter superfamily
H7K75_RS01600	COG4263	nitrous-oxide reductase activity
H7K75_RS01640	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H7K75_RS01645	COG1877	trehalose-phosphatase activity
H7K75_RS01650	COG0477	Major facilitator Superfamily
H7K75_RS01675	COG5002	protein histidine kinase activity
H7K75_RS01675	COG2198	Histidine kinase
H7K75_RS01675	COG0784	Response regulator, receiver
H7K75_RS01720	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7K75_RS01730	COG1522	sequence-specific DNA binding
H7K75_RS01735	COG3813	Protein conserved in bacteria
H7K75_RS01745	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H7K75_RS01760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7K75_RS01765	COG1846	Transcriptional regulator
H7K75_RS01810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7K75_RS01845	COG5001	Diguanylate cyclase
H7K75_RS01850	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H7K75_RS01870	COG2706	6-phosphogluconolactonase activity
H7K75_RS01900	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H7K75_RS01910	COG1696	Membrane protein involved in D-alanine export
H7K75_RS01920	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7K75_RS01955	COG4566	intracellular signal transduction
H7K75_RS01960	COG4191	Histidine kinase
H7K75_RS01960	COG0784	Response regulator, receiver
H7K75_RS01965	COG4566	intracellular signal transduction
H7K75_RS01975	COG2201	protein-glutamate methylesterase activity
H7K75_RS01995	COG0835	chemotaxis
H7K75_RS02000	COG0784	Response regulator, receiver
H7K75_RS02000	COG0643	Histidine kinase
H7K75_RS02000	COG2198	Histidine kinase
H7K75_RS02005	COG3437	response regulator, receiver
H7K75_RS02055	COG0697	spore germination
H7K75_RS02060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7K75_RS02080	COG3181	Tripartite tricarboxylate transporter family receptor
H7K75_RS02090	COG0583	DNA-binding transcription factor activity
H7K75_RS02095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K75_RS02105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7K75_RS02110	COG0473	3-isopropylmalate dehydrogenase activity
H7K75_RS02115	COG0066	3-isopropylmalate dehydratase activity
H7K75_RS02120	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H7K75_RS02125	COG0583	DNA-binding transcription factor activity
H7K75_RS02145	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H7K75_RS02150	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H7K75_RS02170	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H7K75_RS02185	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H7K75_RS02190	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H7K75_RS02195	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H7K75_RS02200	COG0799	negative regulation of ribosome biogenesis
H7K75_RS02205	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H7K75_RS02215	COG0793	Belongs to the peptidase S41A family
H7K75_RS02225	COG1051	belongs to the nudix hydrolase family
H7K75_RS02230	COG0494	nUDIX hydrolase
H7K75_RS02240	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H7K75_RS02245	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H7K75_RS02250	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H7K75_RS02255	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H7K75_RS02260	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H7K75_RS02265	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H7K75_RS02275	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H7K75_RS02290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7K75_RS02295	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS02300	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7K75_RS02310	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H7K75_RS02320	COG0045	succinate-CoA ligase (ADP-forming) activity
H7K75_RS02325	COG0039	L-malate dehydrogenase activity
H7K75_RS02330	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H7K75_RS02335	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H7K75_RS02345	COG4181	ATPase activity
H7K75_RS02350	COG0577	efflux transmembrane transporter activity
H7K75_RS02350	COG1136	(ABC) transporter
H7K75_RS02355	COG0670	Belongs to the BI1 family
H7K75_RS02375	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H7K75_RS02380	COG4133	protoheme IX ABC transporter activity
H7K75_RS02385	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7K75_RS02390	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7K75_RS02400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7K75_RS02405	COG2917	probably involved in intracellular septation
H7K75_RS02410	COG0552	protein localization to endoplasmic reticulum
H7K75_RS02415	COG0564	pseudouridine synthase activity
H7K75_RS02425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7K75_RS02430	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H7K75_RS02450	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H7K75_RS02455	COG0228	four-way junction DNA binding
H7K75_RS02460	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H7K75_RS02475	COG0336	Belongs to the RNA methyltransferase TrmD family
H7K75_RS02480	COG0335	large ribosomal subunit rRNA binding
H7K75_RS02485	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H7K75_RS02525	COG0066	3-isopropylmalate dehydratase activity
H7K75_RS02545	COG2301	Belongs to the HpcH HpaI aldolase family
H7K75_RS02550	COG0288	reversible hydration of carbon dioxide
H7K75_RS02555	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H7K75_RS02570	COG0473	3-isopropylmalate dehydrogenase activity
H7K75_RS02580	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H7K75_RS02585	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
H7K75_RS02590	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H7K75_RS02595	COG4221	oxidoreductase activity
H7K75_RS02600	COG0318	PFAM AMP-dependent synthetase and ligase
H7K75_RS02605	COG0730	response to heat
H7K75_RS02610	COG0583	DNA-binding transcription factor activity
H7K75_RS02635	COG0784	Response regulator, receiver
H7K75_RS02635	COG4191	Histidine kinase
H7K75_RS02640	COG4178	(ABC) transporter
H7K75_RS02660	COG0137	argininosuccinate synthase activity
H7K75_RS02665	COG0671	phosphoesterase, PA-phosphatase related
H7K75_RS02675	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H7K75_RS02685	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS02690	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS02690	COG3321	synthase
H7K75_RS02690	COG0604	alcohol dehydrogenase
H7K75_RS02710	COG2154	pterin-4-alpha-carbinolamine dehydratase
H7K75_RS02725	COG0784	Response regulator, receiver
H7K75_RS02755	COG1217	gtp-binding protein TYPA
H7K75_RS02770	COG3011	Protein conserved in bacteria
H7K75_RS02790	COG1247	-acetyltransferase
H7K75_RS02795	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H7K75_RS02800	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H7K75_RS02820	COG1024	Enoyl-CoA hydratase
H7K75_RS02830	COG4221	oxidoreductase activity
H7K75_RS02855	COG2814	Major facilitator Superfamily
H7K75_RS02900	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H7K75_RS02905	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H7K75_RS02915	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H7K75_RS02930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7K75_RS02935	COG1376	ErfK ybiS ycfS ynhG family protein
H7K75_RS02950	COG4529	Protein conserved in bacteria
H7K75_RS02970	COG0138	bifunctional purine biosynthesis protein purh
H7K75_RS02980	COG0405	Gamma-glutamyltransferase
H7K75_RS02985	COG2814	Major facilitator Superfamily
H7K75_RS03000	COG0534	Mate efflux family protein
H7K75_RS03010	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H7K75_RS03025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7K75_RS03035	COG3118	belongs to the thioredoxin family
H7K75_RS03045	COG3300	MHYT domain
H7K75_RS03045	COG5001	Diguanylate cyclase
H7K75_RS03075	COG2835	tetraacyldisaccharide 4'-kinase activity
H7K75_RS03080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7K75_RS03085	COG1946	Acyl-CoA thioesterase
H7K75_RS03095	COG0347	Belongs to the P(II) protein family
H7K75_RS03100	COG0004	ammonium transporteR
H7K75_RS03105	COG0640	Transcriptional regulator
H7K75_RS03115	COG0740	serine-type endopeptidase activity
H7K75_RS03120	COG0347	Belongs to the P(II) protein family
H7K75_RS03125	COG0004	ammonium transporteR
H7K75_RS03135	COG0436	Aminotransferase
H7K75_RS03140	COG1674	ftsk spoiiie
H7K75_RS03145	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H7K75_RS03160	COG0745	RESPONSE REGULATOR receiver
H7K75_RS03180	COG2203	Gaf domain
H7K75_RS03180	COG3706	GGDEF domain
H7K75_RS03180	COG4251	negative regulation of phosphorylation
H7K75_RS03180	COG5001	Diguanylate cyclase
H7K75_RS03195	COG0495	leucyl-tRNA aminoacylation
H7K75_RS03220	COG0357	Ribosomal RNA small subunit methyltransferase G
H7K75_RS03225	COG0445	tRNA wobble uridine modification
H7K75_RS03230	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H7K75_RS03235	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H7K75_RS03240	COG1981	membrane
H7K75_RS03245	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H7K75_RS03250	COG0424	maF-like protein
H7K75_RS03255	COG0237	dephospho-CoA kinase activity
H7K75_RS03260	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7K75_RS03265	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H7K75_RS03275	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H7K75_RS03290	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H7K75_RS03305	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H7K75_RS03310	COG0131	Imidazoleglycerol-phosphate dehydratase
H7K75_RS03320	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H7K75_RS03325	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H7K75_RS03330	COG0107	imidazoleglycerol-phosphate synthase activity
H7K75_RS03335	COG0140	phosphoribosyl-ATP diphosphatase activity
H7K75_RS03340	COG1072	(Pantothenic acid kinase))
H7K75_RS03355	COG5002	protein histidine kinase activity
H7K75_RS03355	COG2205	protein histidine kinase activity
H7K75_RS03355	COG0784	Response regulator, receiver
H7K75_RS03390	COG4964	Belongs to the GSP D family
H7K75_RS03400	COG0189	ligase activity
H7K75_RS03405	COG0792	nuclease activity
H7K75_RS03410	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H7K75_RS03420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7K75_RS03425	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H7K75_RS03430	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H7K75_RS03435	COG1420	regulation of RNA biosynthetic process
H7K75_RS03440	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H7K75_RS03445	COG1335	isochorismatase
H7K75_RS03455	COG0443	Heat shock 70 kDa protein
H7K75_RS03460	COG0484	heat shock protein binding
H7K75_RS03465	COG3963	phosphatidate phosphatase activity
H7K75_RS03470	COG0431	NADPH-dependent FMN reductase
H7K75_RS03475	COG0284	orotidine-5'-phosphate decarboxylase activity
H7K75_RS03485	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H7K75_RS03490	COG0588	phosphoglycerate mutase activity
H7K75_RS03495	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H7K75_RS03505	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H7K75_RS03535	COG2814	Major facilitator Superfamily
H7K75_RS03545	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7K75_RS03550	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7K75_RS03555	COG0864	Transcriptional regulator
H7K75_RS03565	COG1937	Protein conserved in bacteria
H7K75_RS03585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7K75_RS03585	COG0072	phenylalanine-tRNA ligase activity
H7K75_RS03590	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H7K75_RS03600	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H7K75_RS03605	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H7K75_RS03615	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H7K75_RS03635	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H7K75_RS03645	COG1968	undecaprenyl-diphosphatase activity
H7K75_RS03670	COG1401	restriction endodeoxyribonuclease activity
H7K75_RS03705	COG0515	serine threonine protein kinase
H7K75_RS03705	COG2815	serine threonine protein kinase
H7K75_RS03810	COG3591	Belongs to the peptidase S1B family
H7K75_RS03835	COG2814	Major facilitator Superfamily
H7K75_RS03850	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H7K75_RS03855	COG1137	ATPase activity
H7K75_RS03860	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H7K75_RS03865	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H7K75_RS03870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7K75_RS03890	COG0071	Belongs to the small heat shock protein (HSP20) family
H7K75_RS03895	COG3842	ATPase activity
H7K75_RS03900	COG0395	ABC-type sugar transport system, permease component
H7K75_RS03920	COG1764	response to oxidative stress
H7K75_RS03925	COG1846	Transcriptional regulator
H7K75_RS03940	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H7K75_RS03945	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H7K75_RS03950	COG0539	negative regulation of cytoplasmic translation
H7K75_RS03955	COG0616	signal peptide processing
H7K75_RS03960	COG0776	regulation of translation
H7K75_RS03970	COG0135	phosphoribosylanthranilate isomerase activity
H7K75_RS03975	COG0133	tryptophan synthase activity
H7K75_RS03980	COG0159	tryptophan synthase activity
H7K75_RS03985	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H7K75_RS03990	COG0285	dihydrofolate synthase activity
H7K75_RS04010	COG1074	ATP-dependent DNA helicase activity
H7K75_RS04020	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H7K75_RS04030	COG3178	'Phosphotransferase
H7K75_RS04035	COG2205	protein histidine kinase activity
H7K75_RS04040	COG0756	dUTP diphosphatase activity
H7K75_RS04045	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H7K75_RS04050	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H7K75_RS04055	COG2226	methyltransferase
H7K75_RS04060	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H7K75_RS04075	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7K75_RS04095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7K75_RS04105	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7K75_RS04115	COG0625	glutathione transferase activity
H7K75_RS04140	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H7K75_RS04145	COG1185	polyribonucleotide nucleotidyltransferase activity
H7K75_RS04150	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H7K75_RS04155	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H7K75_RS04160	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H7K75_RS04165	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H7K75_RS04180	COG0779	Required for maturation of 30S ribosomal subunits
H7K75_RS04190	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H7K75_RS04200	COG1396	sequence-specific DNA binding
H7K75_RS04205	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H7K75_RS04210	COG1253	flavin adenine dinucleotide binding
H7K75_RS04215	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H7K75_RS04220	COG1702	phosphate starvation-inducible protein PhoH
H7K75_RS04225	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7K75_RS04230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7K75_RS04260	COG0180	Tryptophanyl-tRNA synthetase
H7K75_RS04270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7K75_RS04300	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H7K75_RS04305	COG1741	Belongs to the pirin family
H7K75_RS04345	COG0534	Mate efflux family protein
H7K75_RS04350	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H7K75_RS04375	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H7K75_RS04380	COG2852	Protein conserved in bacteria
H7K75_RS04390	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H7K75_RS04395	COG0268	Binds directly to 16S ribosomal RNA
H7K75_RS04405	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7K75_RS04420	COG0412	Dienelactone hydrolase
H7K75_RS04490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7K75_RS04505	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H7K75_RS04510	COG1032	radical SAM domain protein
H7K75_RS04565	COG0582	viral genome integration into host DNA
H7K75_RS04695	COG5001	Diguanylate cyclase
H7K75_RS04715	COG0411	ABC transporter
H7K75_RS04735	COG3829	transcription factor binding
H7K75_RS04735	COG3290	protein histidine kinase activity
H7K75_RS04740	COG5001	Diguanylate cyclase
H7K75_RS04750	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS04770	COG0477	Major facilitator Superfamily
H7K75_RS04780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7K75_RS04785	COG0366	Alpha amylase catalytic
H7K75_RS04800	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H7K75_RS04810	COG1131	(ABC) transporter
H7K75_RS04830	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H7K75_RS04860	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H7K75_RS04870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K75_RS04895	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H7K75_RS04900	COG0183	Belongs to the thiolase family
H7K75_RS04905	COG3485	protocatechuate 3,4-dioxygenase
H7K75_RS04910	COG3485	protocatechuate 3,4-dioxygenase
H7K75_RS04915	COG3485	protocatechuate 3,4-dioxygenase
H7K75_RS04930	COG2814	Major facilitator Superfamily
H7K75_RS04935	COG1566	PFAM secretion protein HlyD family protein
H7K75_RS04945	COG0735	belongs to the Fur family
H7K75_RS04955	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H7K75_RS04960	COG2175	clavaminate synthase activity
H7K75_RS04975	COG0025	NhaP-type Na H and K H
H7K75_RS05005	COG0142	geranyltranstransferase activity
H7K75_RS05010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7K75_RS05015	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H7K75_RS05030	COG3300	MHYT domain
H7K75_RS05030	COG5001	Diguanylate cyclase
H7K75_RS05050	COG5001	Diguanylate cyclase
H7K75_RS05060	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H7K75_RS05070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7K75_RS05075	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H7K75_RS05080	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H7K75_RS05095	COG2072	flavoprotein involved in K transport
H7K75_RS05100	COG0745	RESPONSE REGULATOR receiver
H7K75_RS05105	COG5002	protein histidine kinase activity
H7K75_RS05105	COG2198	Histidine kinase
H7K75_RS05105	COG0784	Response regulator, receiver
H7K75_RS05125	COG1129	ABC transporter
H7K75_RS05145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7K75_RS05185	COG1960	acyl-CoA dehydrogenase activity
H7K75_RS05190	COG1960	acyl-CoA dehydrogenase activity
H7K75_RS05205	COG3246	L-lysine catabolic process to acetate
H7K75_RS05210	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7K75_RS05225	COG4608	Belongs to the ABC transporter superfamily
H7K75_RS05230	COG0444	Belongs to the ABC transporter superfamily
H7K75_RS05235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K75_RS05240	COG0601	transmembrane transport
H7K75_RS05260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K75_RS05270	COG0683	leucine binding
H7K75_RS05275	COG3788	relative of glutathione S-transferase, MAPEG superfamily
H7K75_RS05305	COG2271	Major facilitator Superfamily
H7K75_RS05325	COG0737	Belongs to the 5'-nucleotidase family
H7K75_RS05335	COG3258	Cytochrome c
H7K75_RS05350	COG4654	Cytochrome c, class I
H7K75_RS05360	COG1505	serine-type exopeptidase activity
H7K75_RS05365	COG2814	Major facilitator Superfamily
H7K75_RS05375	COG2514	catechol 2,3-dioxygenase activity
H7K75_RS05385	COG1960	acyl-CoA dehydrogenase activity
H7K75_RS05390	COG1960	acyl-CoA dehydrogenase activity
H7K75_RS05395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K75_RS05420	COG1595	DNA-templated transcription, initiation
H7K75_RS05430	COG3437	response regulator, receiver
H7K75_RS05430	COG0784	Response regulator, receiver
H7K75_RS05435	COG4191	Histidine kinase
H7K75_RS05435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K75_RS05440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H7K75_RS05465	COG0747	negative chemotaxis
H7K75_RS05470	COG0601	transmembrane transport
H7K75_RS05475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K75_RS05480	COG4172	Belongs to the ABC transporter superfamily
H7K75_RS05500	COG1802	Transcriptional regulator
H7K75_RS05515	COG0318	PFAM AMP-dependent synthetase and ligase
H7K75_RS05525	COG2124	cytochrome p450
H7K75_RS05540	COG1252	NADH dehydrogenase
H7K75_RS05565	COG4177	L-phenylalanine transmembrane transporter activity
H7K75_RS05580	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7K75_RS05585	COG0583	DNA-binding transcription factor activity
H7K75_RS05595	COG2197	response regulator
H7K75_RS05600	COG3916	Acyl-homoserine-lactone synthase
H7K75_RS05640	COG4638	Rieske (2fe-2S)
H7K75_RS05645	COG1414	Transcriptional regulator
H7K75_RS05670	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H7K75_RS05675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7K75_RS05710	COG3047	cAMP biosynthetic process
H7K75_RS05710	COG2885	chlorophyll binding
H7K75_RS05725	COG0596	Alpha beta hydrolase
H7K75_RS05745	COG5002	protein histidine kinase activity
H7K75_RS05750	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H7K75_RS05755	COG0573	inorganic phosphate transmembrane transporter activity
H7K75_RS05760	COG0581	inorganic phosphate transmembrane transporter activity
H7K75_RS05765	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H7K75_RS05770	COG0704	Plays a role in the regulation of phosphate uptake
H7K75_RS05775	COG0745	RESPONSE REGULATOR receiver
H7K75_RS05785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7K75_RS05790	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H7K75_RS05805	COG2967	ApaG domain
H7K75_RS05830	COG0717	Belongs to the dCTP deaminase family
H7K75_RS05875	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H7K75_RS06005	COG2267	carboxylic ester hydrolase activity
H7K75_RS06010	COG1396	sequence-specific DNA binding
H7K75_RS06030	COG1070	Carbohydrate kinase
H7K75_RS06035	COG2115	Belongs to the xylose isomerase family
H7K75_RS06040	COG1129	ABC transporter
H7K75_RS06045	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7K75_RS06075	COG0251	oxidation-reduction process
H7K75_RS06100	COG1999	signal sequence binding
H7K75_RS06110	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
H7K75_RS06145	COG0167	dihydroorotate dehydrogenase activity
H7K75_RS06155	COG1234	tRNA 3'-trailer cleavage
H7K75_RS06185	COG1201	RNA secondary structure unwinding
H7K75_RS06195	COG0583	DNA-binding transcription factor activity
H7K75_RS06200	COG0697	spore germination
H7K75_RS06215	COG0730	response to heat
H7K75_RS06225	COG1695	Transcriptional regulator
H7K75_RS06235	COG1960	acyl-CoA dehydrogenase activity
H7K75_RS06240	COG0183	Belongs to the thiolase family
H7K75_RS06245	COG1024	Enoyl-CoA hydratase
H7K75_RS06245	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7K75_RS06250	COG3344	reverse transcriptase
H7K75_RS06260	COG0625	glutathione transferase activity
H7K75_RS06285	COG0681	Belongs to the peptidase S26 family
H7K75_RS06290	COG0312	modulator of DNA gyrase
H7K75_RS06300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H7K75_RS06305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7K75_RS06310	COG0109	protoheme IX farnesyltransferase activity
H7K75_RS06320	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H7K75_RS06335	COG3346	SURF1 family
H7K75_RS06360	COG0612	Peptidase, M16
H7K75_RS06365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7K75_RS06375	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H7K75_RS06380	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H7K75_RS06390	COG0356	it plays a direct role in the translocation of protons across the membrane
H7K75_RS06410	COG0432	Pfam Uncharacterised protein family UPF0047
H7K75_RS06430	COG1764	response to oxidative stress
H7K75_RS06435	COG0596	Alpha beta hydrolase
H7K75_RS06445	COG0784	Response regulator, receiver
H7K75_RS06445	COG2205	protein histidine kinase activity
H7K75_RS06450	COG0156	8-amino-7-oxononanoate synthase activity
H7K75_RS06455	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H7K75_RS06505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K75_RS06550	COG2020	methyltransferase activity
H7K75_RS06560	COG2188	Transcriptional regulator
H7K75_RS06565	COG3624	Phosphonate C-P lyase system protein PhnG
H7K75_RS06570	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
H7K75_RS06575	COG3626	phosphonate metabolism
H7K75_RS06580	COG3627	carbon phosphorus lyase activity
H7K75_RS06585	COG4107	phosphonate C-P lyase system protein PhnK
H7K75_RS06590	COG4778	phosphonate C-P lyase system protein PhnL
H7K75_RS06595	COG3454	Phosphonate metabolism
H7K75_RS06600	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
H7K75_RS06620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7K75_RS06625	COG2267	carboxylic ester hydrolase activity
H7K75_RS06640	COG3181	Tripartite tricarboxylate transporter family receptor
H7K75_RS06645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7K75_RS06650	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7K75_RS06655	COG3971	2-oxopent-4-enoate hydratase activity
H7K75_RS06670	COG2197	response regulator
H7K75_RS06695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7K75_RS06700	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H7K75_RS06780	COG0492	ferredoxin-NADP+ reductase activity
H7K75_RS06810	COG0702	epimerase
H7K75_RS06820	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H7K75_RS06825	COG5328	Belongs to the UPF0262 family
H7K75_RS06830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H7K75_RS06835	COG0424	maF-like protein
H7K75_RS06840	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H7K75_RS06850	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H7K75_RS06855	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
H7K75_RS06875	COG3052	prosthetic group binding
H7K75_RS06895	COG2186	Transcriptional regulator
H7K75_RS06905	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H7K75_RS06935	COG1335	isochorismatase
H7K75_RS06945	COG1022	Amp-dependent synthetase and ligase
H7K75_RS06950	COG4716	Myosin-crossreactive antigen
H7K75_RS06955	COG4191	Histidine kinase
H7K75_RS06980	COG0667	Aldo Keto reductase
H7K75_RS07025	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS07060	COG3047	cAMP biosynthetic process
H7K75_RS07075	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H7K75_RS07080	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H7K75_RS07085	COG0328	RNA-DNA hybrid ribonuclease activity
H7K75_RS07090	COG0678	peroxiredoxin activity
H7K75_RS07090	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H7K75_RS07100	COG0318	PFAM AMP-dependent synthetase and ligase
H7K75_RS07105	COG1686	Belongs to the peptidase S11 family
H7K75_RS07110	COG1132	(ABC) transporter
H7K75_RS07130	COG0140	phosphoribosyl-ATP diphosphatase activity
H7K75_RS07135	COG1238	metal cluster binding
H7K75_RS07145	COG1027	Aspartate ammonia-lyase
H7K75_RS07160	COG0318	PFAM AMP-dependent synthetase and ligase
H7K75_RS07165	COG2070	2-Nitropropane dioxygenase
H7K75_RS07200	COG4585	Histidine kinase
H7K75_RS07230	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H7K75_RS07275	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7K75_RS07275	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7K75_RS07290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7K75_RS07295	COG1473	amidohydrolase
H7K75_RS07305	COG0601	transmembrane transport
H7K75_RS07310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K75_RS07315	COG0444	Belongs to the ABC transporter superfamily
H7K75_RS07320	COG4608	Belongs to the ABC transporter superfamily
H7K75_RS07340	COG2203	Gaf domain
H7K75_RS07340	COG5001	Diguanylate cyclase
H7K75_RS07340	COG4251	negative regulation of phosphorylation
H7K75_RS07340	COG3706	GGDEF domain
H7K75_RS07345	COG3360	Dodecin
H7K75_RS07350	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
H7K75_RS07350	COG2273	Hydrolase Family 16
H7K75_RS07355	COG2723	6-phospho-beta-galactosidase activity
H7K75_RS07390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7K75_RS07395	COG2205	protein histidine kinase activity
H7K75_RS07395	COG2198	Histidine kinase
H7K75_RS07395	COG0784	Response regulator, receiver
H7K75_RS07415	COG2086	electron transfer activity
H7K75_RS07420	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H7K75_RS07425	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7K75_RS07435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7K75_RS07440	COG0165	Argininosuccinate lyase
H7K75_RS07450	COG0019	diaminopimelate decarboxylase activity
H7K75_RS07460	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7K75_RS07475	COG2204	response regulator
H7K75_RS07485	COG2884	Cell division ATP-binding protein ftsE
H7K75_RS07515	COG0287	Prephenate dehydrogenase
H7K75_RS07520	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7K75_RS07530	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7K75_RS07535	COG2813	Specifically methylates the guanine in position
H7K75_RS07535	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7K75_RS07540	COG0596	Alpha beta hydrolase
H7K75_RS07555	COG0542	response to heat
H7K75_RS07570	COG0739	heme binding
H7K75_RS07610	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS07615	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H7K75_RS07630	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H7K75_RS07635	COG0640	Transcriptional regulator
H7K75_RS07665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7K75_RS07670	COG1605	Chorismate mutase
H7K75_RS07670	COG0077	Prephenate dehydratase
H7K75_RS07675	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H7K75_RS07680	COG3474	cytochrome
H7K75_RS07685	COG4166	transmembrane transport
H7K75_RS07690	COG4166	transmembrane transport
H7K75_RS07695	COG4174	ABC transporter (Permease)
H7K75_RS07700	COG4239	(ABC) transporter, permease
H7K75_RS07705	COG4172	Belongs to the ABC transporter superfamily
H7K75_RS07725	COG0791	NLP P60 protein
H7K75_RS07730	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7K75_RS07770	COG4964	Belongs to the GSP D family
H7K75_RS07805	COG1278	Cold shock
H7K75_RS07810	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H7K75_RS07815	COG0513	Belongs to the DEAD box helicase family
H7K75_RS07845	COG0829	nickel cation binding
H7K75_RS07850	COG0831	urea catabolic process
H7K75_RS07855	COG0832	Belongs to the urease beta subunit family
H7K75_RS07860	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7K75_RS07865	COG0804	urea catabolic process
H7K75_RS07880	COG0830	nickel cation binding
H7K75_RS07885	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H7K75_RS07895	COG0251	oxidation-reduction process
H7K75_RS07920	COG0628	permease
H7K75_RS07925	COG1388	LysM domain
H7K75_RS07925	COG1376	ErfK ybiS ycfS ynhG family protein
H7K75_RS07950	COG3237	CsbD-like
H7K75_RS07955	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H7K75_RS07970	COG1648	precorrin-2 dehydrogenase activity
H7K75_RS07970	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7K75_RS07980	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7K75_RS07990	COG0175	sulfate reduction
H7K75_RS07995	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H7K75_RS08000	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H7K75_RS08005	COG4208	sulfate ABC transporter
H7K75_RS08010	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H7K75_RS08025	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS08030	COG0730	response to heat
H7K75_RS08045	COG1678	Uncharacterized ACR, COG1678
H7K75_RS08055	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS08060	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS08065	COG3237	CsbD-like
H7K75_RS08075	COG2951	lytic endotransglycosylase activity
H7K75_RS08080	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H7K75_RS08085	COG4251	negative regulation of phosphorylation
H7K75_RS08085	COG5001	Diguanylate cyclase
H7K75_RS08085	COG3706	GGDEF domain
H7K75_RS08085	COG2203	Gaf domain
H7K75_RS08100	COG3321	synthase
H7K75_RS08100	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS08100	COG0604	alcohol dehydrogenase
H7K75_RS08115	COG0254	rRNA binding
H7K75_RS08120	COG1132	(ABC) transporter
H7K75_RS08145	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H7K75_RS08155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K75_RS08160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K75_RS08165	COG0483	inositol monophosphate 1-phosphatase activity
H7K75_RS08180	COG3588	fructose-bisphosphate aldolase
H7K75_RS08190	COG0126	phosphoglycerate kinase activity
H7K75_RS08225	COG1692	metallophosphoesterase
H7K75_RS08250	COG0840	transmembrane signaling receptor activity
H7K75_RS08255	COG0217	transcriptional regulatory protein
H7K75_RS08260	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H7K75_RS08265	COG0632	four-way junction helicase activity
H7K75_RS08270	COG2255	four-way junction helicase activity
H7K75_RS08280	COG1408	metallophosphoesterase
H7K75_RS08350	COG5001	Diguanylate cyclase
H7K75_RS08355	COG1858	cytochrome C peroxidase
H7K75_RS08460	COG0747	negative chemotaxis
H7K75_RS08465	COG0601	transmembrane transport
H7K75_RS08470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K75_RS08520	COG4227	nucleotidyltransferase activity
H7K75_RS08580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K75_RS08585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7K75_RS08595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H7K75_RS08720	COG0765	amino acid transport
H7K75_RS08740	COG4886	Leucine-rich repeat (LRR) protein
H7K75_RS08925	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7K75_RS08945	COG3436	PFAM IS66 Orf2 family protein
H7K75_RS08965	COG3831	ATPase activity
H7K75_RS08995	COG4566	intracellular signal transduction
H7K75_RS09000	COG4566	intracellular signal transduction
H7K75_RS09005	COG4191	Histidine kinase
H7K75_RS09020	COG1301	dicarboxylic acid transport
H7K75_RS09030	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
H7K75_RS09035	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
H7K75_RS09040	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
H7K75_RS09050	COG0298	carbon dioxide binding
H7K75_RS09055	COG1773	rubredoxin
H7K75_RS09065	COG0375	protein maturation
H7K75_RS09080	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
H7K75_RS09080	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
H7K75_RS09085	COG0409	Hydrogenase expression formation protein
H7K75_RS09090	COG0309	Hydrogenase expression formation protein (HypE)
H7K75_RS09095	COG0686	Belongs to the AlaDH PNT family
H7K75_RS09100	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7K75_RS09115	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H7K75_RS09120	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H7K75_RS09125	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H7K75_RS09130	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H7K75_RS09145	COG5420	small protein containing a coiled-coil domain
H7K75_RS09170	COG0316	Belongs to the HesB IscA family
H7K75_RS09180	COG1104	cysteine desulfurase activity
H7K75_RS09185	COG5554	nitrogen fixation
H7K75_RS09190	COG0535	radical SAM domain protein
H7K75_RS09195	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7K75_RS09200	COG5554	nitrogen fixation
H7K75_RS09220	COG3411	Ferredoxin
H7K75_RS09225	COG3047	cAMP biosynthetic process
H7K75_RS09235	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
H7K75_RS09250	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H7K75_RS09255	COG0644	oxidoreductase
H7K75_RS09260	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H7K75_RS09265	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7K75_RS09280	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H7K75_RS09310	COG0612	Peptidase, M16
H7K75_RS09320	COG5010	COG0457 FOG TPR repeat
H7K75_RS09325	COG4789	Type iii secretion
H7K75_RS09390	COG4669	(LipO)protein
H7K75_RS09400	COG1317	bacterial-type flagellum organization
H7K75_RS09405	COG1157	protein secretion by the type III secretion system
H7K75_RS09415	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7K75_RS09420	COG4790	Type iii secretion
H7K75_RS09425	COG4794	Type iii secretion
H7K75_RS09430	COG4791	protein targeting
H7K75_RS09435	COG4792	protein secretion
H7K75_RS09530	COG5461	TIGRFAM pilus (Caulobacter type) biogenesis lipoprotein CpaD
H7K75_RS09535	COG4964	Belongs to the GSP D family
H7K75_RS09540	COG0745	RESPONSE REGULATOR receiver
H7K75_RS09565	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H7K75_RS09580	COG2801	Transposase and inactivated derivatives
H7K75_RS09585	COG3293	Transposase
H7K75_RS09660	COG2771	luxR family
H7K75_RS09665	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H7K75_RS09700	COG1175	transmembrane transport
H7K75_RS09705	COG0395	ABC-type sugar transport system, permease component
H7K75_RS09710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7K75_RS09715	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS09730	COG5564	TIM-barrel signal transduction protein
H7K75_RS09730	COG2204	response regulator
H7K75_RS09745	COG5564	TIM-barrel signal transduction protein
H7K75_RS09750	COG1053	succinate dehydrogenase
H7K75_RS09795	COG1024	Enoyl-CoA hydratase
H7K75_RS09800	COG0477	Major facilitator Superfamily
H7K75_RS09810	COG1609	Transcriptional regulator
H7K75_RS09855	COG0436	Aminotransferase
H7K75_RS09880	COG3591	Belongs to the peptidase S1B family
H7K75_RS09950	COG3550	peptidyl-serine autophosphorylation
H7K75_RS10025	COG5564	TIM-barrel signal transduction protein
H7K75_RS10030	COG1053	succinate dehydrogenase
H7K75_RS10035	COG1522	sequence-specific DNA binding
H7K75_RS10165	COG2188	Transcriptional regulator
H7K75_RS10170	COG4750	Nucleotidyl transferase
H7K75_RS10180	COG2771	luxR family
H7K75_RS10225	COG1505	serine-type exopeptidase activity
H7K75_RS10230	COG1278	Cold shock
H7K75_RS10240	COG2814	Major facilitator Superfamily
H7K75_RS10325	COG4886	Leucine-rich repeat (LRR) protein
H7K75_RS10380	COG0419	ATPase involved in DNA repair
H7K75_RS10385	COG0420	3'-5' exonuclease activity
H7K75_RS10460	COG2801	Transposase and inactivated derivatives
H7K75_RS10500	COG1278	Cold shock
H7K75_RS10505	COG5489	Protein of unknown function (DUF736)
H7K75_RS10520	COG1301	dicarboxylic acid transport
H7K75_RS10530	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
H7K75_RS10535	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
H7K75_RS10540	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
H7K75_RS10550	COG0298	carbon dioxide binding
H7K75_RS10555	COG1773	rubredoxin
H7K75_RS10565	COG0375	protein maturation
H7K75_RS10580	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
H7K75_RS10580	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
H7K75_RS10585	COG0409	Hydrogenase expression formation protein
H7K75_RS10590	COG0309	Hydrogenase expression formation protein (HypE)
H7K75_RS10595	COG0686	Belongs to the AlaDH PNT family
H7K75_RS10600	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7K75_RS10615	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H7K75_RS10620	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H7K75_RS10625	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H7K75_RS10630	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H7K75_RS10645	COG5420	small protein containing a coiled-coil domain
H7K75_RS10670	COG0316	Belongs to the HesB IscA family
H7K75_RS10680	COG1104	cysteine desulfurase activity
H7K75_RS10685	COG5554	nitrogen fixation
H7K75_RS10690	COG0535	radical SAM domain protein
H7K75_RS10695	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7K75_RS10700	COG5554	nitrogen fixation
H7K75_RS10720	COG3411	Ferredoxin
H7K75_RS10725	COG3047	cAMP biosynthetic process
H7K75_RS10735	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
H7K75_RS10750	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H7K75_RS10755	COG0644	oxidoreductase
H7K75_RS10760	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H7K75_RS10765	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7K75_RS10780	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H7K75_RS10810	COG0612	Peptidase, M16
H7K75_RS10820	COG5010	COG0457 FOG TPR repeat
H7K75_RS10825	COG4789	Type iii secretion
H7K75_RS10890	COG4669	(LipO)protein
H7K75_RS10900	COG1317	bacterial-type flagellum organization
H7K75_RS10905	COG1157	protein secretion by the type III secretion system
H7K75_RS10915	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7K75_RS10920	COG4790	Type iii secretion
H7K75_RS10925	COG4794	Type iii secretion
H7K75_RS10930	COG4791	protein targeting
H7K75_RS10935	COG4792	protein secretion
H7K75_RS11030	COG5461	TIGRFAM pilus (Caulobacter type) biogenesis lipoprotein CpaD
H7K75_RS11035	COG4964	Belongs to the GSP D family
H7K75_RS11040	COG0745	RESPONSE REGULATOR receiver
H7K75_RS11065	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H7K75_RS11080	COG2801	Transposase and inactivated derivatives
H7K75_RS11085	COG3293	Transposase
H7K75_RS11160	COG2771	luxR family
H7K75_RS11165	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H7K75_RS11200	COG1175	transmembrane transport
H7K75_RS11205	COG0395	ABC-type sugar transport system, permease component
H7K75_RS11210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7K75_RS11215	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS11230	COG5564	TIM-barrel signal transduction protein
H7K75_RS11230	COG2204	response regulator
H7K75_RS11245	COG5564	TIM-barrel signal transduction protein
H7K75_RS11250	COG1053	succinate dehydrogenase
H7K75_RS11295	COG1024	Enoyl-CoA hydratase
H7K75_RS11300	COG0477	Major facilitator Superfamily
H7K75_RS11310	COG1609	Transcriptional regulator
H7K75_RS11355	COG0436	Aminotransferase
H7K75_RS11380	COG3591	Belongs to the peptidase S1B family
H7K75_RS11450	COG3550	peptidyl-serine autophosphorylation
H7K75_RS11525	COG5564	TIM-barrel signal transduction protein
H7K75_RS11530	COG1053	succinate dehydrogenase
H7K75_RS11535	COG1522	sequence-specific DNA binding
H7K75_RS11665	COG2188	Transcriptional regulator
H7K75_RS11670	COG4750	Nucleotidyl transferase
H7K75_RS11680	COG2771	luxR family
H7K75_RS11725	COG1505	serine-type exopeptidase activity
H7K75_RS11730	COG1278	Cold shock
H7K75_RS11740	COG2814	Major facilitator Superfamily
H7K75_RS11825	COG4886	Leucine-rich repeat (LRR) protein
H7K75_RS11880	COG0419	ATPase involved in DNA repair
H7K75_RS11885	COG0420	3'-5' exonuclease activity
H7K75_RS11960	COG2801	Transposase and inactivated derivatives
H7K75_RS12000	COG1278	Cold shock
H7K75_RS12005	COG5489	Protein of unknown function (DUF736)
H7K75_RS12130	COG3550	peptidyl-serine autophosphorylation
H7K75_RS12210	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7K75_RS12220	COG2771	luxR family
H7K75_RS12250	COG0789	Transcriptional regulator
H7K75_RS12260	COG0583	DNA-binding transcription factor activity
H7K75_RS12265	COG0583	DNA-binding transcription factor activity
H7K75_RS12270	COG3153	acetyltransferase
H7K75_RS12280	COG1215	transferase activity, transferring glycosyl groups
H7K75_RS12285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7K75_RS12290	COG2192	nodulation
H7K75_RS12295	COG1131	(ABC) transporter
H7K75_RS12300	COG0842	Transport permease protein
H7K75_RS12305	COG2192	nodulation
H7K75_RS12310	COG2192	nodulation
H7K75_RS12320	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS12325	COG3604	Transcriptional regulator
H7K75_RS12330	COG2086	electron transfer activity
H7K75_RS12370	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H7K75_RS12385	COG3344	reverse transcriptase
H7K75_RS12410	COG0459	protein refolding
H7K75_RS12415	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H7K75_RS12420	COG0275	rRNA processing
H7K75_RS12450	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H7K75_RS12485	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H7K75_RS12500	COG0174	glutamine synthetase
H7K75_RS12535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H7K75_RS12550	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H7K75_RS12555	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H7K75_RS12560	COG0156	8-amino-7-oxononanoate synthase activity
H7K75_RS12565	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H7K75_RS12570	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7K75_RS12575	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H7K75_RS12580	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H7K75_RS12605	COG0662	Cupin 2, conserved barrel domain protein
H7K75_RS12665	COG1278	Cold shock
H7K75_RS12740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7K75_RS12740	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7K75_RS12745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7K75_RS12755	COG0582	viral genome integration into host DNA
H7K75_RS12760	COG4974	Belongs to the 'phage' integrase family
H7K75_RS12785	COG2124	cytochrome p450
H7K75_RS12790	COG2124	cytochrome p450
H7K75_RS12800	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS12805	COG2124	cytochrome p450
H7K75_RS12810	COG0142	geranyltranstransferase activity
H7K75_RS12815	COG1657	PFAM Prenyltransferase squalene oxidase
H7K75_RS12865	COG3328	transposase activity
H7K75_RS12880	COG0583	DNA-binding transcription factor activity
H7K75_RS12885	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS12890	COG3959	Transketolase, thiamine diphosphate binding domain
H7K75_RS12895	COG3958	Transketolase
H7K75_RS12900	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H7K75_RS12925	COG0784	Response regulator, receiver
H7K75_RS12925	COG4191	Histidine kinase
H7K75_RS12930	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H7K75_RS12935	COG4191	Histidine kinase
H7K75_RS12935	COG0784	Response regulator, receiver
H7K75_RS12945	COG3920	Histidine kinase
H7K75_RS12985	COG1218	3'(2'),5'-bisphosphate nucleotidase
H7K75_RS12995	COG0643	Histidine kinase
H7K75_RS12995	COG2198	Histidine kinase
H7K75_RS12995	COG0784	Response regulator, receiver
H7K75_RS13000	COG0835	chemotaxis
H7K75_RS13005	COG0784	Response regulator, receiver
H7K75_RS13005	COG0643	Histidine kinase
H7K75_RS13005	COG2198	Histidine kinase
H7K75_RS13010	COG2201	protein-glutamate methylesterase activity
H7K75_RS13025	COG0754	glutathionylspermidine amidase activity
H7K75_RS13035	COG3766	membrane
H7K75_RS13055	COG1595	DNA-templated transcription, initiation
H7K75_RS13080	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H7K75_RS13125	COG1309	transcriptional regulator
H7K75_RS13130	COG2080	2 iron, 2 sulfur cluster binding
H7K75_RS13135	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H7K75_RS13140	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7K75_RS13150	COG3620	sequence-specific DNA binding
H7K75_RS13155	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7K75_RS13160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K75_RS13170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K75_RS13175	COG0765	amino acid transport
H7K75_RS13180	COG1126	abc transporter atp-binding protein
H7K75_RS13185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K75_RS13195	COG0405	Gamma-glutamyltransferase
H7K75_RS13200	COG1024	Enoyl-CoA hydratase
H7K75_RS13255	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7K75_RS13330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7K75_RS13355	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7K75_RS13425	COG1129	ABC transporter
H7K75_RS13430	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7K75_RS13440	COG1335	isochorismatase
H7K75_RS13445	COG0583	DNA-binding transcription factor activity
H7K75_RS13485	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7K75_RS13555	COG0303	'Molybdopterin
H7K75_RS13565	COG0746	molybdenum cofactor guanylyltransferase activity
H7K75_RS13575	COG1763	Mo-molybdopterin cofactor biosynthetic process
H7K75_RS13590	COG2223	nitrite transmembrane transporter activity
H7K75_RS13600	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H7K75_RS13605	COG3383	formate dehydrogenase (NAD+) activity
H7K75_RS13610	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H7K75_RS13650	COG3447	MASE1 domain protein
H7K75_RS13650	COG5002	protein histidine kinase activity
H7K75_RS13650	COG5001	Diguanylate cyclase
H7K75_RS13655	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H7K75_RS13665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7K75_RS13670	COG0346	lactoylglutathione lyase activity
H7K75_RS13680	COG0583	DNA-binding transcription factor activity
H7K75_RS13685	COG3485	protocatechuate 3,4-dioxygenase
H7K75_RS13690	COG3485	protocatechuate 3,4-dioxygenase
H7K75_RS13730	COG0745	RESPONSE REGULATOR receiver
H7K75_RS13735	COG0643	Histidine kinase
H7K75_RS13735	COG2198	Histidine kinase
H7K75_RS13740	COG0835	chemotaxis
H7K75_RS13745	COG0840	transmembrane signaling receptor activity
H7K75_RS13750	COG0835	chemotaxis
H7K75_RS13755	COG0840	transmembrane signaling receptor activity
H7K75_RS13765	COG2201	protein-glutamate methylesterase activity
H7K75_RS13810	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H7K75_RS13820	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H7K75_RS13840	COG0489	protein tyrosine kinase activity
H7K75_RS13840	COG3206	protein involved in exopolysaccharide biosynthesis
H7K75_RS13865	COG2755	lipolytic protein G-D-S-L family
H7K75_RS13865	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H7K75_RS13875	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H7K75_RS13880	COG2244	polysaccharide biosynthetic process
H7K75_RS13885	COG1045	serine acetyltransferase
H7K75_RS13890	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7K75_RS13900	COG0438	transferase activity, transferring glycosyl groups
H7K75_RS13950	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H7K75_RS13980	COG3474	cytochrome
H7K75_RS14000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7K75_RS14015	COG5001	Diguanylate cyclase
H7K75_RS14015	COG3300	MHYT domain
H7K75_RS14025	COG1309	transcriptional regulator
H7K75_RS14035	COG0181	hydroxymethylbilane synthase activity
H7K75_RS14040	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H7K75_RS14050	COG2203	Gaf domain
H7K75_RS14050	COG5001	Diguanylate cyclase
H7K75_RS14050	COG4251	negative regulation of phosphorylation
H7K75_RS14050	COG3706	GGDEF domain
H7K75_RS14055	COG2900	Belongs to the SlyX family
H7K75_RS14060	COG1054	Belongs to the UPF0176 family
H7K75_RS14065	COG0405	Gamma-glutamyltransferase
H7K75_RS14075	COG3237	CsbD-like
H7K75_RS14115	COG2885	chlorophyll binding
H7K75_RS14115	COG3047	cAMP biosynthetic process
H7K75_RS14135	COG3214	Protein conserved in bacteria
H7K75_RS14160	COG1309	transcriptional regulator
H7K75_RS14180	COG1024	Enoyl-CoA hydratase
H7K75_RS14180	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7K75_RS14190	COG1607	acyl-coa hydrolase
H7K75_RS14210	COG1349	DNA-binding transcription factor activity
H7K75_RS14230	COG3842	ATPase activity
H7K75_RS14235	COG3842	ATPase activity
H7K75_RS14245	COG0395	ABC-type sugar transport system, permease component
H7K75_RS14265	COG2197	response regulator
H7K75_RS14270	COG1902	pentaerythritol trinitrate reductase activity
H7K75_RS14295	COG0501	Belongs to the peptidase M48B family
H7K75_RS14345	COG0494	nUDIX hydrolase
H7K75_RS14350	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H7K75_RS14355	COG4771	TonB-dependent receptor
H7K75_RS14380	COG0714	Associated with various cellular activities
H7K75_RS14400	COG0617	tRNA 3'-terminal CCA addition
H7K75_RS14430	COG1917	Cupin 2, conserved barrel domain protein
H7K75_RS14430	COG1396	sequence-specific DNA binding
H7K75_RS14435	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H7K75_RS14440	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
H7K75_RS14450	COG3293	Transposase
H7K75_RS14475	COG0408	coproporphyrinogen oxidase activity
H7K75_RS14485	COG0602	queuosine metabolic process
H7K75_RS14490	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H7K75_RS14495	COG0723	plastoquinol--plastocyanin reductase activity
H7K75_RS14500	COG2857	Cytochrome c1
H7K75_RS14500	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H7K75_RS14520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7K75_RS14540	COG1704	LemA family
H7K75_RS14550	COG1196	nuclear chromosome segregation
H7K75_RS14555	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7K75_RS14555	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7K75_RS14565	COG1194	a g-specific adenine glycosylase
H7K75_RS14590	COG0625	glutathione transferase activity
H7K75_RS14620	COG0625	glutathione transferase activity
H7K75_RS14630	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H7K75_RS14635	COG2321	neutral zinc metallopeptidase
H7K75_RS14640	COG0521	Mo-molybdopterin cofactor biosynthetic process
H7K75_RS14650	COG0456	acetyltransferase
H7K75_RS14650	COG1846	Transcriptional regulator
H7K75_RS14665	COG0574	Belongs to the PEP-utilizing enzyme family
H7K75_RS14665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7K75_RS14680	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
H7K75_RS14695	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H7K75_RS14705	COG1573	uracil-dna glycosylase
H7K75_RS14720	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H7K75_RS14730	COG1280	lysine exporter protein (LysE YggA)
H7K75_RS14735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7K75_RS14745	COG0142	geranyltranstransferase activity
H7K75_RS14770	COG0752	glycyl-tRNA synthetase alpha subunit
H7K75_RS14775	COG0751	glycine-tRNA ligase activity
H7K75_RS14790	COG0574	Belongs to the PEP-utilizing enzyme family
H7K75_RS14790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7K75_RS14805	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H7K75_RS14810	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H7K75_RS14820	COG0604	alcohol dehydrogenase
H7K75_RS14840	COG0840	transmembrane signaling receptor activity
H7K75_RS14870	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
H7K75_RS14875	COG0519	Catalyzes the synthesis of GMP from XMP
H7K75_RS14880	COG0354	folic acid binding
H7K75_RS14885	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7K75_RS14890	COG2897	thiosulfate sulfurtransferase activity
H7K75_RS14895	COG1595	DNA-templated transcription, initiation
H7K75_RS14930	COG2135	peptidase activity
H7K75_RS14945	COG0494	nUDIX hydrolase
H7K75_RS14955	COG0277	FAD linked oxidase domain protein
H7K75_RS14960	COG0009	L-threonylcarbamoyladenylate synthase
H7K75_RS15000	COG1309	transcriptional regulator
H7K75_RS15005	COG2814	Major facilitator Superfamily
H7K75_RS15025	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H7K75_RS15045	COG1850	ribulose-bisphosphate carboxylase activity
H7K75_RS15050	COG4451	ribulose bisphosphate carboxylase, small
H7K75_RS15065	COG5001	Diguanylate cyclase
H7K75_RS15065	COG3300	MHYT domain
H7K75_RS15130	COG4999	Histidine kinase
H7K75_RS15130	COG3437	response regulator, receiver
H7K75_RS15130	COG2205	protein histidine kinase activity
H7K75_RS15130	COG3850	Histidine kinase
H7K75_RS15220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7K75_RS15230	COG0475	glutathione-regulated potassium exporter activity
H7K75_RS15230	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H7K75_RS15240	COG1960	acyl-CoA dehydrogenase activity
H7K75_RS15255	COG0318	PFAM AMP-dependent synthetase and ligase
H7K75_RS15270	COG0598	Magnesium transport protein CorA
H7K75_RS15280	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS15285	COG0259	pyridoxamine-phosphate oxidase activity
H7K75_RS15310	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7K75_RS15320	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H7K75_RS15330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7K75_RS15345	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H7K75_RS15350	COG1993	acr, cog1993
H7K75_RS15355	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H7K75_RS15360	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H7K75_RS15380	COG1024	Enoyl-CoA hydratase
H7K75_RS15405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7K75_RS15410	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H7K75_RS15420	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H7K75_RS15425	COG1722	exodeoxyribonuclease VII activity
H7K75_RS15430	COG0123	including yeast histone deacetylase and acetoin utilization protein
H7K75_RS15435	COG0737	Belongs to the 5'-nucleotidase family
H7K75_RS15435	COG4085	toxin activity
H7K75_RS15435	COG1525	nuclease
H7K75_RS15450	COG2223	nitrite transmembrane transporter activity
H7K75_RS15455	COG1960	acyl-CoA dehydrogenase activity
H7K75_RS15490	COG3119	arylsulfatase activity
H7K75_RS15545	COG1879	ABC-type sugar transport system periplasmic component
H7K75_RS15550	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7K75_RS15555	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7K75_RS15560	COG1129	ABC transporter
H7K75_RS15565	COG0277	FAD linked oxidase domain protein
H7K75_RS15570	COG3485	protocatechuate 3,4-dioxygenase
H7K75_RS15575	COG2084	Dehydrogenase
H7K75_RS15580	COG0402	S-adenosylhomocysteine deaminase activity
H7K75_RS15595	COG0583	DNA-binding transcription factor activity
H7K75_RS15610	COG0477	Major facilitator Superfamily
H7K75_RS15615	COG1012	belongs to the aldehyde dehydrogenase family
H7K75_RS15625	COG2814	Major facilitator Superfamily
H7K75_RS15650	COG1858	cytochrome C peroxidase
H7K75_RS15665	COG1473	amidohydrolase
H7K75_RS15710	COG0741	lytic transglycosylase activity
H7K75_RS15760	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7K75_RS15770	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H7K75_RS15790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7K75_RS15795	COG1053	succinate dehydrogenase
H7K75_RS15810	COG1335	isochorismatase
H7K75_RS15830	COG3833	ABC-type maltose transport systems, permease component
H7K75_RS15835	COG1175	transmembrane transport
H7K75_RS15840	COG1653	transport
H7K75_RS15845	COG3258	Cytochrome c
H7K75_RS15865	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7K75_RS15870	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7K75_RS15870	COG2010	Cytochrome c
H7K75_RS15885	COG1032	radical SAM domain protein
H7K75_RS15890	COG2814	Major facilitator Superfamily
H7K75_RS15895	COG0473	3-isopropylmalate dehydrogenase activity
H7K75_RS15920	COG2264	protein methyltransferase activity
H7K75_RS15930	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS15935	COG4106	trans-aconitate 2-methyltransferase activity
H7K75_RS15950	COG2015	COG2015, Alkyl sulfatase and related hydrolases
H7K75_RS15955	COG0438	transferase activity, transferring glycosyl groups
H7K75_RS15960	COG1132	(ABC) transporter
H7K75_RS15980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7K75_RS15985	COG0745	RESPONSE REGULATOR receiver
H7K75_RS15990	COG4566	intracellular signal transduction
H7K75_RS15995	COG4191	Histidine kinase
H7K75_RS16005	COG0516	GMP reductase activity
H7K75_RS16005	COG0517	IMP dehydrogenase activity
H7K75_RS16010	COG3278	Belongs to the heme-copper respiratory oxidase family
H7K75_RS16025	COG2010	Cytochrome c
H7K75_RS16040	COG2217	Heavy metal translocating P-type atpase
H7K75_RS16070	COG0583	DNA-binding transcription factor activity
H7K75_RS16085	COG0297	glycogen (starch) synthase activity
H7K75_RS16100	COG0473	3-isopropylmalate dehydrogenase activity
H7K75_RS16110	COG1024	Enoyl-CoA hydratase
H7K75_RS16115	COG2989	Protein conserved in bacteria
H7K75_RS16120	COG1396	sequence-specific DNA binding
H7K75_RS16135	COG0785	Cytochrome C biogenesis protein
H7K75_RS16140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7K75_RS16145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7K75_RS16160	COG2207	Transcriptional regulator
H7K75_RS16185	COG3485	protocatechuate 3,4-dioxygenase
H7K75_RS16190	COG0515	serine threonine protein kinase
H7K75_RS16200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7K75_RS16205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K75_RS16210	COG1116	anion transmembrane transporter activity
H7K75_RS16215	COG2223	nitrite transmembrane transporter activity
H7K75_RS16220	COG1017	nitric oxide dioxygenase activity
H7K75_RS16220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7K75_RS16225	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7K75_RS16230	COG0243	molybdopterin cofactor binding
H7K75_RS16235	COG0656	L-ascorbic acid biosynthetic process
H7K75_RS16245	COG1063	alcohol dehydrogenase
H7K75_RS16255	COG1522	sequence-specific DNA binding
H7K75_RS16260	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H7K75_RS16275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7K75_RS16315	COG0129	dihydroxy-acid dehydratase activity
H7K75_RS16345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7K75_RS16350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7K75_RS16360	COG1309	transcriptional regulator
H7K75_RS16365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K75_RS16385	COG0673	inositol 2-dehydrogenase activity
H7K75_RS16435	COG1980	fructose-bisphosphate aldolase activity
H7K75_RS16445	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H7K75_RS16455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7K75_RS16460	COG2124	cytochrome p450
H7K75_RS16470	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
H7K75_RS16470	COG0028	Belongs to the TPP enzyme family
H7K75_RS16480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K75_RS16485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K75_RS16500	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H7K75_RS16510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K75_RS16515	COG0601	transmembrane transport
H7K75_RS16520	COG0747	negative chemotaxis
H7K75_RS16525	COG4608	Belongs to the ABC transporter superfamily
H7K75_RS16530	COG0444	Belongs to the ABC transporter superfamily
H7K75_RS16550	COG0444	Belongs to the ABC transporter superfamily
H7K75_RS16555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K75_RS16565	COG0747	negative chemotaxis
H7K75_RS16585	COG2267	carboxylic ester hydrolase activity
H7K75_RS16590	COG2124	cytochrome p450
H7K75_RS16590	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7K75_RS16625	COG2733	membrane
H7K75_RS16630	COG0596	Alpha beta hydrolase
H7K75_RS16635	COG3327	negative regulation of DNA-templated transcription, initiation
H7K75_RS16640	COG3396	Phenylacetate-CoA oxygenase
H7K75_RS16645	COG3460	Phenylacetate-CoA oxygenase
H7K75_RS16650	COG3396	Phenylacetate-CoA oxygenase
H7K75_RS16655	COG2151	metal-sulfur cluster biosynthetic enzyme
H7K75_RS16660	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7K75_RS16665	COG2050	protein possibly involved in aromatic compounds catabolism
H7K75_RS16700	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H7K75_RS16705	COG0477	Major facilitator Superfamily
H7K75_RS16730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K75_RS16735	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7K75_RS16745	COG4597	amino acid ABC transporter
H7K75_RS16750	COG0765	amino acid transport
H7K75_RS16760	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS16765	COG0473	3-isopropylmalate dehydrogenase activity
H7K75_RS16770	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H7K75_RS16775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7K75_RS16785	COG0583	DNA-binding transcription factor activity
H7K75_RS16790	COG4336	lyase activity
H7K75_RS16820	COG0235	Class ii aldolase
H7K75_RS16825	COG2084	Dehydrogenase
H7K75_RS16830	COG3622	Belongs to the hyi family
H7K75_RS16835	COG3395	kinase activity
H7K75_RS16845	COG0840	transmembrane signaling receptor activity
H7K75_RS16850	COG0840	transmembrane signaling receptor activity
H7K75_RS16850	COG0840	transmembrane signaling receptor activity
H7K75_RS16870	COG2070	2-Nitropropane dioxygenase
H7K75_RS16875	COG2072	flavoprotein involved in K transport
H7K75_RS16880	COG0625	glutathione transferase activity
H7K75_RS16895	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS16900	COG1024	Enoyl-CoA hydratase
H7K75_RS16915	COG1024	Enoyl-CoA hydratase
H7K75_RS16920	COG1960	acyl-CoA dehydrogenase activity
H7K75_RS16935	COG1024	Enoyl-CoA hydratase
H7K75_RS16945	COG1024	Enoyl-CoA hydratase
H7K75_RS16960	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H7K75_RS16965	COG3386	PFAM SMP-30 Gluconolaconase
H7K75_RS16970	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS17000	COG3145	DNA-N1-methyladenine dioxygenase activity
H7K75_RS17010	COG0028	Belongs to the TPP enzyme family
H7K75_RS17015	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7K75_RS17025	COG1012	belongs to the aldehyde dehydrogenase family
H7K75_RS17035	COG3971	2-oxopent-4-enoate hydratase activity
H7K75_RS17040	COG1846	Transcriptional regulator
H7K75_RS17055	COG2721	sulfolactate sulfo-lyase activity
H7K75_RS17140	COG4303	Ethanolamine ammonia lyase large subunit
H7K75_RS17150	COG4302	ethanolamine ammonia-lyase activity
H7K75_RS17175	COG1562	ergosterol biosynthetic process
H7K75_RS17180	COG1562	ergosterol biosynthetic process
H7K75_RS17185	COG1233	COG1233 Phytoene dehydrogenase and related
H7K75_RS17190	COG1657	PFAM Prenyltransferase squalene oxidase
H7K75_RS17195	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H7K75_RS17205	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H7K75_RS17240	COG1595	DNA-templated transcription, initiation
H7K75_RS17275	COG1473	amidohydrolase
H7K75_RS17280	COG0306	phosphate transporter
H7K75_RS17285	COG1573	uracil-dna glycosylase
H7K75_RS17300	COG0587	DNA-directed DNA polymerase activity
H7K75_RS17305	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS17315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7K75_RS17345	COG1024	Enoyl-CoA hydratase
H7K75_RS17405	COG1703	isobutyryl-CoA mutase activity
H7K75_RS17450	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H7K75_RS17460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H7K75_RS17475	COG0433	COG0433 Predicted ATPase
H7K75_RS17505	COG4957	zinc ion binding
H7K75_RS17510	COG2166	iron-sulfur cluster assembly
H7K75_RS17520	COG2205	protein histidine kinase activity
H7K75_RS17555	COG0583	DNA-binding transcription factor activity
H7K75_RS17600	COG0798	PFAM Bile acid sodium symporter
H7K75_RS17650	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H7K75_RS17660	COG0765	amino acid transport
H7K75_RS17665	COG0765	amino acid transport
H7K75_RS17670	COG1126	abc transporter atp-binding protein
H7K75_RS17690	COG2983	Belongs to the UPF0260 family
H7K75_RS17695	COG0477	Major facilitator Superfamily
H7K75_RS17705	COG4191	Histidine kinase
H7K75_RS17705	COG0784	Response regulator, receiver
H7K75_RS17710	COG0028	Belongs to the TPP enzyme family
H7K75_RS17735	COG0463	Glycosyl transferase, family 2
H7K75_RS17750	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H7K75_RS17755	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H7K75_RS17760	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H7K75_RS17780	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H7K75_RS17810	COG4235	cytochrome complex assembly
H7K75_RS17815	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H7K75_RS17820	COG1138	Cytochrome C-type biogenesis protein
H7K75_RS17825	COG3088	subunit of a heme lyase
H7K75_RS17840	COG0745	RESPONSE REGULATOR receiver
H7K75_RS17845	COG2205	protein histidine kinase activity
H7K75_RS17850	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H7K75_RS17860	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H7K75_RS17865	COG3383	formate dehydrogenase (NAD+) activity
H7K75_RS17880	COG0583	DNA-binding transcription factor activity
H7K75_RS17885	COG2202	Pas domain
H7K75_RS17885	COG2205	protein histidine kinase activity
H7K75_RS17890	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H7K75_RS17895	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS17895	COG0604	alcohol dehydrogenase
H7K75_RS17895	COG3321	synthase
H7K75_RS17920	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7K75_RS17925	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H7K75_RS17950	COG0443	Heat shock 70 kDa protein
H7K75_RS17960	COG1278	Cold shock
H7K75_RS17980	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7K75_RS17990	COG1802	Transcriptional regulator
H7K75_RS18025	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H7K75_RS18030	COG3960	tartronate-semialdehyde synthase activity
H7K75_RS18035	COG3622	Belongs to the hyi family
H7K75_RS18040	COG2084	Dehydrogenase
H7K75_RS18065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7K75_RS18085	COG1982	Orn Lys Arg decarboxylase major
H7K75_RS18090	COG1522	sequence-specific DNA binding
H7K75_RS18095	COG0686	Belongs to the AlaDH PNT family
H7K75_RS18100	COG2072	flavoprotein involved in K transport
H7K75_RS18105	COG1309	transcriptional regulator
H7K75_RS18135	COG0410	ABC transporter
H7K75_RS18145	COG2855	membrane
H7K75_RS18150	COG1116	anion transmembrane transporter activity
H7K75_RS18155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K75_RS18160	COG4521	taurine ABC transporter
H7K75_RS18165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7K75_RS18180	COG1053	succinate dehydrogenase
H7K75_RS18200	COG1879	ABC-type sugar transport system periplasmic component
H7K75_RS18205	COG1129	ABC transporter
H7K75_RS18210	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7K75_RS18215	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7K75_RS18235	COG3386	PFAM SMP-30 Gluconolaconase
H7K75_RS18240	COG4213	ABC transporter substrate-binding protein
H7K75_RS18245	COG1129	ABC transporter
H7K75_RS18250	COG4214	carbohydrate transport
H7K75_RS18260	COG1845	cytochrome c oxidase, subunit III
H7K75_RS18275	COG3256	nitric oxide reductase
H7K75_RS18280	COG0714	Associated with various cellular activities
H7K75_RS18290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7K75_RS18320	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS18350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K75_RS18360	COG4608	Belongs to the ABC transporter superfamily
H7K75_RS18365	COG0747	negative chemotaxis
H7K75_RS18400	COG3842	ATPase activity
H7K75_RS18405	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H7K75_RS18410	COG1177	transmembrane transport
H7K75_RS18415	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7K75_RS18425	COG0400	carboxylic ester hydrolase activity
H7K75_RS18430	COG0346	lactoylglutathione lyase activity
H7K75_RS18435	COG0583	DNA-binding transcription factor activity
H7K75_RS18465	COG0778	Nitroreductase
H7K75_RS18470	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H7K75_RS18480	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H7K75_RS18490	COG1492	cobalamin metabolic process
H7K75_RS18535	COG2099	Precorrin-6x reductase
H7K75_RS18550	COG2875	Belongs to the precorrin methyltransferase family
H7K75_RS18555	COG1797	cobyrinic acid a,c-diamide synthase activity
H7K75_RS18560	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7K75_RS18560	COG1648	precorrin-2 dehydrogenase activity
H7K75_RS18575	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H7K75_RS18595	COG0154	amidase activity
H7K75_RS18605	COG2351	hydroxyisourate hydrolase activity
H7K75_RS18615	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7K75_RS18620	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H7K75_RS18625	COG3842	ATPase activity
H7K75_RS18630	COG0154	amidase activity
H7K75_RS18640	COG1802	Transcriptional regulator
H7K75_RS18650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K75_RS18655	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H7K75_RS18670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K75_RS18675	COG2030	dehydratase
H7K75_RS18680	COG4670	ketone body catabolic process
H7K75_RS18685	COG1960	acyl-CoA dehydrogenase activity
H7K75_RS18695	COG1609	Transcriptional regulator
H7K75_RS18700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7K75_RS18705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7K75_RS18725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7K75_RS18740	COG0765	amino acid transport
H7K75_RS18745	COG1126	abc transporter atp-binding protein
H7K75_RS18755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7K75_RS18760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K75_RS18770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7K75_RS18775	COG0235	Class ii aldolase
H7K75_RS18795	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7K75_RS18810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7K75_RS18830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7K75_RS18835	COG0318	PFAM AMP-dependent synthetase and ligase
H7K75_RS18845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7K75_RS18865	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS18870	COG2072	flavoprotein involved in K transport
H7K75_RS18875	COG0747	negative chemotaxis
H7K75_RS18880	COG0601	transmembrane transport
H7K75_RS18885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K75_RS18895	COG0747	negative chemotaxis
H7K75_RS18900	COG0601	transmembrane transport
H7K75_RS18905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K75_RS18910	COG0444	Belongs to the ABC transporter superfamily
H7K75_RS18915	COG4608	Belongs to the ABC transporter superfamily
H7K75_RS18935	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7K75_RS18960	COG0559	Belongs to the binding-protein-dependent transport system permease family
H7K75_RS18980	COG2146	nitrite reductase [NAD(P)H] activity
H7K75_RS19010	COG0445	tRNA wobble uridine modification
H7K75_RS19025	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H7K75_RS19030	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7K75_RS19035	COG3386	PFAM SMP-30 Gluconolaconase
H7K75_RS19045	COG3618	amidohydrolase
H7K75_RS19090	COG2268	Band 7 protein
H7K75_RS19090	COG2268	Band 7 protein
H7K75_RS19095	COG5564	TIM-barrel signal transduction protein
H7K75_RS19140	COG1175	transmembrane transport
H7K75_RS19145	COG0395	ABC-type sugar transport system, permease component
H7K75_RS19150	COG0673	inositol 2-dehydrogenase activity
H7K75_RS19160	COG1609	Transcriptional regulator
H7K75_RS19170	COG0477	Major facilitator Superfamily
H7K75_RS19175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7K75_RS19180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7K75_RS19190	COG4638	Rieske (2fe-2S)
H7K75_RS19200	COG0318	PFAM AMP-dependent synthetase and ligase
H7K75_RS19205	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS19215	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7K75_RS19255	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7K75_RS19275	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7K75_RS19280	COG0596	Alpha beta hydrolase
H7K75_RS19290	COG1846	Transcriptional regulator
H7K75_RS19330	COG1764	response to oxidative stress
H7K75_RS19345	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
H7K75_RS19375	COG0251	oxidation-reduction process
H7K75_RS19390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7K75_RS19410	COG3181	Tripartite tricarboxylate transporter family receptor
H7K75_RS19415	COG1024	Enoyl-CoA hydratase
H7K75_RS19430	COG1960	acyl-CoA dehydrogenase activity
H7K75_RS19435	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS19465	COG0628	permease
H7K75_RS19480	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H7K75_RS19485	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7K75_RS19495	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H7K75_RS19500	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H7K75_RS19530	COG4566	intracellular signal transduction
H7K75_RS19550	COG2985	domain, Protein
H7K75_RS19570	COG2985	domain, Protein
H7K75_RS19575	COG2985	domain, Protein
H7K75_RS19615	COG4191	Histidine kinase
H7K75_RS19620	COG3064	Membrane
H7K75_RS19650	COG0489	protein tyrosine kinase activity
H7K75_RS19685	COG4964	Belongs to the GSP D family
H7K75_RS19710	COG0640	Transcriptional regulator
H7K75_RS19720	COG0785	Cytochrome C biogenesis protein
H7K75_RS19755	COG0737	Belongs to the 5'-nucleotidase family
H7K75_RS19760	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H7K75_RS19785	COG2391	methyltransferase activity
H7K75_RS19790	COG2391	methyltransferase activity
H7K75_RS19800	COG0640	Transcriptional regulator
H7K75_RS19825	COG4977	sequence-specific DNA binding
H7K75_RS19825	COG1917	Cupin 2, conserved barrel domain protein
H7K75_RS19850	COG1024	Enoyl-CoA hydratase
H7K75_RS19865	COG3395	kinase activity
H7K75_RS19870	COG0235	Class ii aldolase
H7K75_RS19875	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7K75_RS19880	COG3842	ATPase activity
H7K75_RS19890	COG1177	transmembrane transport
H7K75_RS19940	COG2205	protein histidine kinase activity
H7K75_RS19945	COG0745	RESPONSE REGULATOR receiver
H7K75_RS19980	COG1175	transmembrane transport
H7K75_RS19985	COG0395	ABC-type sugar transport system, permease component
H7K75_RS20005	COG1461	Dihydroxyacetone kinase
H7K75_RS20010	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
H7K75_RS20020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7K75_RS20030	COG2376	Dihydroxyacetone kinase
H7K75_RS20070	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H7K75_RS20070	COG4797	methyltransferase
H7K75_RS20125	COG1716	ATPase activity
H7K75_RS20135	COG2885	chlorophyll binding
H7K75_RS20155	COG2815	serine threonine protein kinase
H7K75_RS20155	COG0515	serine threonine protein kinase
H7K75_RS20230	COG0436	Aminotransferase
H7K75_RS20250	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS20255	COG3836	Belongs to the HpcH HpaI aldolase family
H7K75_RS20270	COG0436	Aminotransferase
H7K75_RS20275	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7K75_RS20290	COG3842	ATPase activity
H7K75_RS20295	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H7K75_RS20300	COG1984	allophanate hydrolase subunit 2
H7K75_RS20305	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H7K75_RS20315	COG1984	allophanate hydrolase subunit 2
H7K75_RS20325	COG0439	Biotin carboxylase
H7K75_RS20330	COG0511	ligase activity, forming carbon-carbon bonds
H7K75_RS20335	COG4221	oxidoreductase activity
H7K75_RS20345	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7K75_RS20380	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7K75_RS20405	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS20420	COG1053	succinate dehydrogenase
H7K75_RS20425	COG1053	succinate dehydrogenase
H7K75_RS20430	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7K75_RS20435	COG0410	ABC transporter
H7K75_RS20440	COG0559	Belongs to the binding-protein-dependent transport system permease family
H7K75_RS20460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7K75_RS20475	COG1053	succinate dehydrogenase
H7K75_RS20490	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS20495	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS20510	COG3350	monooxygenase activity
H7K75_RS20540	COG0459	protein refolding
H7K75_RS20595	COG1595	DNA-templated transcription, initiation
H7K75_RS20600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7K75_RS20605	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H7K75_RS20625	COG1749	Flagellar hook protein flgE
H7K75_RS20660	COG0577	efflux transmembrane transporter activity
H7K75_RS20660	COG1136	(ABC) transporter
H7K75_RS20680	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7K75_RS20695	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H7K75_RS20705	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7K75_RS20710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7K75_RS20715	COG1301	dicarboxylic acid transport
H7K75_RS20720	COG0183	Belongs to the thiolase family
H7K75_RS20730	COG0280	phosphate acetyltransferase
H7K75_RS20730	COG0281	malic enzyme
H7K75_RS20735	COG1252	NADH dehydrogenase
H7K75_RS20740	COG1271	oxidase subunit
H7K75_RS20745	COG1294	oxidase, subunit
H7K75_RS20755	COG2204	response regulator
H7K75_RS20760	COG3243	poly(R)-hydroxyalkanoic acid synthase
H7K75_RS20765	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7K75_RS20785	COG2202	Pas domain
H7K75_RS20785	COG2205	protein histidine kinase activity
H7K75_RS20790	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H7K75_RS20795	COG2084	Dehydrogenase
H7K75_RS20810	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H7K75_RS20820	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H7K75_RS20835	COG0745	RESPONSE REGULATOR receiver
H7K75_RS20855	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H7K75_RS20860	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H7K75_RS20870	COG0546	phosphoglycolate phosphatase activity
H7K75_RS20875	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H7K75_RS20890	COG3546	catalase activity
H7K75_RS20945	COG0121	glutamine amidotransferase
H7K75_RS20955	COG1017	nitric oxide dioxygenase activity
H7K75_RS20955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7K75_RS20975	COG0861	Integral membrane protein TerC family
H7K75_RS20990	COG0583	DNA-binding transcription factor activity
H7K75_RS21005	COG1012	belongs to the aldehyde dehydrogenase family
H7K75_RS21020	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H7K75_RS21025	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H7K75_RS21050	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7K75_RS21055	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H7K75_RS21075	COG0215	cysteine-tRNA ligase activity
H7K75_RS21085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7K75_RS21100	COG5265	(ABC) transporter
H7K75_RS21105	COG0688	phosphatidylethanolamine metabolic process
H7K75_RS21110	COG1183	phosphatidylcholine synthase activity
H7K75_RS21125	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS21130	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7K75_RS21140	COG3158	transport of potassium into the cell
H7K75_RS21145	COG3158	transport of potassium into the cell
H7K75_RS21155	COG0436	Aminotransferase
H7K75_RS21160	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H7K75_RS21170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7K75_RS21180	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7K75_RS21185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7K75_RS21225	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H7K75_RS21230	COG1285	pathogenesis
H7K75_RS21250	COG2010	Cytochrome c
H7K75_RS21250	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7K75_RS21255	COG2080	2 iron, 2 sulfur cluster binding
H7K75_RS21295	COG1846	Transcriptional regulator
H7K75_RS21350	COG3618	amidohydrolase
H7K75_RS21355	COG1301	dicarboxylic acid transport
H7K75_RS21360	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H7K75_RS21415	COG1289	transmembrane transporter activity
H7K75_RS21435	COG0318	PFAM AMP-dependent synthetase and ligase
H7K75_RS21440	COG2072	flavoprotein involved in K transport
H7K75_RS21445	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7K75_RS21515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K75_RS21520	COG1309	transcriptional regulator
H7K75_RS21530	COG2814	Major facilitator Superfamily
H7K75_RS21535	COG1012	belongs to the aldehyde dehydrogenase family
H7K75_RS21540	COG1802	Transcriptional regulator
H7K75_RS21550	COG0477	Major facilitator Superfamily
H7K75_RS21555	COG0402	S-adenosylhomocysteine deaminase activity
H7K75_RS21565	COG1234	tRNA 3'-trailer cleavage
H7K75_RS21575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7K75_RS21580	COG0277	FAD linked oxidase domain protein
H7K75_RS21585	COG3395	kinase activity
H7K75_RS21590	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H7K75_RS21595	COG1454	alcohol dehydrogenase
H7K75_RS21625	COG5507	3-demethylubiquinone-9 3-methyltransferase
H7K75_RS21650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K75_RS21655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K75_RS21665	COG4774	siderophore transport
H7K75_RS21670	COG3128	pkhd-type hydroxylase
H7K75_RS21680	COG0848	biopolymer transport protein
H7K75_RS21695	COG1994	Peptidase M50
H7K75_RS21705	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H7K75_RS21710	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS21715	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS21720	COG0129	dihydroxy-acid dehydratase activity
H7K75_RS21725	COG1609	Transcriptional regulator
H7K75_RS21730	COG3842	ATPase activity
H7K75_RS21745	COG3833	ABC-type maltose transport systems, permease component
H7K75_RS21750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7K75_RS21755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7K75_RS21760	COG0800	Aldolase
H7K75_RS21765	COG0183	Belongs to the thiolase family
H7K75_RS21775	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7K75_RS21780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7K75_RS21790	COG2186	Transcriptional regulator
H7K75_RS21795	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7K75_RS21800	COG0747	negative chemotaxis
H7K75_RS21820	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
H7K75_RS21820	COG2066	Belongs to the glutaminase family
H7K75_RS21835	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H7K75_RS21845	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7K75_RS21885	COG2271	Major facilitator Superfamily
H7K75_RS21890	COG0183	Belongs to the thiolase family
H7K75_RS21895	COG1024	Enoyl-CoA hydratase
H7K75_RS21920	COG1960	acyl-CoA dehydrogenase activity
H7K75_RS21935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7K75_RS21945	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS21950	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7K75_RS21950	COG0493	'glutamate synthase
H7K75_RS21955	COG2814	Major facilitator Superfamily
H7K75_RS21960	COG0583	DNA-binding transcription factor activity
H7K75_RS21970	COG0488	(ABC) transporter
H7K75_RS21975	COG1671	Belongs to the UPF0178 family
H7K75_RS21995	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H7K75_RS22010	COG2130	NADP-dependent
H7K75_RS22020	COG1609	Transcriptional regulator
H7K75_RS22030	COG0251	oxidation-reduction process
H7K75_RS22035	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H7K75_RS22045	COG0765	amino acid transport
H7K75_RS22050	COG0765	amino acid transport
H7K75_RS22080	COG1278	Cold shock
H7K75_RS22095	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7K75_RS22095	COG0519	Catalyzes the synthesis of GMP from XMP
H7K75_RS22105	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS22110	COG0583	DNA-binding transcription factor activity
H7K75_RS22120	COG1510	regulation of RNA biosynthetic process
H7K75_RS22140	COG1012	belongs to the aldehyde dehydrogenase family
H7K75_RS22160	COG2207	Transcriptional regulator
H7K75_RS22175	COG0242	peptide deformylase activity
H7K75_RS22195	COG2814	Major facilitator Superfamily
H7K75_RS22210	COG1764	response to oxidative stress
H7K75_RS22215	COG1846	Transcriptional regulator
H7K75_RS22235	COG1301	dicarboxylic acid transport
H7K75_RS22240	COG1802	Transcriptional regulator
H7K75_RS22250	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS22255	COG0583	DNA-binding transcription factor activity
H7K75_RS22265	COG3415	Transposase
H7K75_RS22265	COG2801	Transposase and inactivated derivatives
H7K75_RS22310	COG0625	glutathione transferase activity
H7K75_RS22320	COG1309	transcriptional regulator
H7K75_RS22325	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7K75_RS22325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7K75_RS22330	COG1393	Belongs to the ArsC family
H7K75_RS22365	COG1392	Phosphate transport regulator
H7K75_RS22370	COG0306	phosphate transporter
H7K75_RS22395	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H7K75_RS22415	COG1160	GTP binding
H7K75_RS22450	COG0300	oxidoreductase activity
H7K75_RS22455	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H7K75_RS22460	COG1286	toxin biosynthetic process
H7K75_RS22470	COG1879	ABC-type sugar transport system periplasmic component
H7K75_RS22510	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7K75_RS22515	COG0305	Participates in initiation and elongation during chromosome replication
H7K75_RS22525	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H7K75_RS22545	COG0359	binds to the 23S rRNA
H7K75_RS22555	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H7K75_RS22560	COG0360	Binds together with S18 to 16S ribosomal RNA
H7K75_RS22575	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H7K75_RS22585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7K75_RS22590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7K75_RS22595	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H7K75_RS22600	COG1561	YicC-like family, N-terminal region
H7K75_RS22605	COG0194	GDP metabolic process
H7K75_RS22680	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H7K75_RS22685	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H7K75_RS22705	COG0795	lipopolysaccharide-transporting ATPase activity
H7K75_RS22710	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7K75_RS22740	COG3162	membrane
H7K75_RS22745	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7K75_RS22755	COG2176	DNA-directed DNA polymerase activity
H7K75_RS22760	COG0488	(ABC) transporter
H7K75_RS22775	COG0105	UTP biosynthetic process
H7K75_RS22780	COG0861	Integral membrane protein TerC family
H7K75_RS22785	COG0248	Ppx GppA phosphatase
H7K75_RS22790	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H7K75_RS22800	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H7K75_RS22805	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H7K75_RS22810	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H7K75_RS22815	COG1278	Cold shock
H7K75_RS22850	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7K75_RS22855	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H7K75_RS22880	COG1175	transmembrane transport
H7K75_RS22890	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H7K75_RS22895	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H7K75_RS22905	COG0281	malic enzyme
H7K75_RS22905	COG0280	phosphate acetyltransferase
H7K75_RS22925	COG0386	Belongs to the glutathione peroxidase family
H7K75_RS22935	COG3045	CreA protein
H7K75_RS22970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7K75_RS22980	COG3483	tryptophan 2,3-dioxygenase activity
H7K75_RS23015	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS23020	COG2365	Tyrosine phosphatase family
H7K75_RS23040	COG0174	glutamine synthetase
H7K75_RS23090	COG2207	Transcriptional regulator
H7K75_RS23110	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS23115	COG0488	(ABC) transporter
H7K75_RS23140	COG0657	acetylesterase activity
H7K75_RS23150	COG0840	transmembrane signaling receptor activity
H7K75_RS23175	COG2207	Transcriptional regulator
H7K75_RS23225	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H7K75_RS23250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K75_RS23255	COG1309	transcriptional regulator
H7K75_RS23265	COG0850	regulation of cytokinetic process
H7K75_RS23270	COG2894	cell division
H7K75_RS23275	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H7K75_RS23295	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS23310	COG1376	ErfK ybiS ycfS ynhG family protein
H7K75_RS23350	COG1309	transcriptional regulator
H7K75_RS23375	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H7K75_RS23415	COG2824	Alkylphosphonate utilization operon protein PhnA
H7K75_RS23505	COG1335	isochorismatase
H7K75_RS23540	COG1574	metal-dependent hydrolase with the TIM-barrel fold
H7K75_RS23580	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7K75_RS23615	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7K75_RS23620	COG0697	spore germination
H7K75_RS23625	COG4191	Histidine kinase
H7K75_RS23625	COG0784	Response regulator, receiver
H7K75_RS23655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7K75_RS23665	COG0657	acetylesterase activity
H7K75_RS23675	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H7K75_RS23680	COG0745	RESPONSE REGULATOR receiver
H7K75_RS23685	COG0784	Response regulator, receiver
H7K75_RS23690	COG5002	protein histidine kinase activity
H7K75_RS23695	COG0439	Biotin carboxylase
H7K75_RS23700	COG0511	ligase activity, forming carbon-carbon bonds
H7K75_RS23705	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H7K75_RS23725	COG0436	Aminotransferase
H7K75_RS23730	COG1268	BioY protein
H7K75_RS23735	COG1301	dicarboxylic acid transport
H7K75_RS23755	COG2271	Major facilitator Superfamily
H7K75_RS23770	COG1530	ribonuclease E activity
H7K75_RS23770	COG1530	ribonuclease E activity
H7K75_RS23775	COG0860	N-Acetylmuramoyl-L-alanine amidase
H7K75_RS23780	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H7K75_RS23790	COG2084	Dehydrogenase
H7K75_RS23800	COG0697	spore germination
H7K75_RS23825	COG0438	transferase activity, transferring glycosyl groups
H7K75_RS23845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K75_RS23850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K75_RS23865	COG0739	heme binding
H7K75_RS23870	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H7K75_RS23895	COG2259	Doxx family
H7K75_RS23905	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H7K75_RS23910	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H7K75_RS23915	COG0625	glutathione transferase activity
H7K75_RS23930	COG2945	thiolester hydrolase activity
H7K75_RS23945	COG1104	cysteine desulfurase activity
H7K75_RS23950	COG0719	Fe-S assembly protein
H7K75_RS23955	COG0396	ATPase activity
H7K75_RS23960	COG0719	Fe-S assembly protein
H7K75_RS23965	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H7K75_RS23970	COG2151	metal-sulfur cluster biosynthetic enzyme
H7K75_RS23975	COG0316	Belongs to the HesB IscA family
H7K75_RS23985	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7K75_RS23995	COG0513	Belongs to the DEAD box helicase family
H7K75_RS24025	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS24040	COG0187	DNA topoisomerase II activity
H7K75_RS24045	COG0586	Pfam SNARE associated Golgi protein
H7K75_RS24070	COG3243	poly(R)-hydroxyalkanoic acid synthase
H7K75_RS24080	COG0436	Aminotransferase
H7K75_RS24090	COG1494	fructose-1,6-bisphosphatase
H7K75_RS24110	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H7K75_RS24115	COG1802	Transcriptional regulator
H7K75_RS24125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7K75_RS24145	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H7K75_RS24155	COG0840	transmembrane signaling receptor activity
H7K75_RS24160	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H7K75_RS24185	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7K75_RS24205	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H7K75_RS24210	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H7K75_RS24225	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7K75_RS24340	COG3750	Belongs to the UPF0335 family
H7K75_RS24420	COG0616	signal peptide processing
H7K75_RS24600	COG0625	glutathione transferase activity
H7K75_RS24620	COG2267	carboxylic ester hydrolase activity
H7K75_RS24640	COG0776	regulation of translation
H7K75_RS24680	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H7K75_RS24725	COG1522	sequence-specific DNA binding
H7K75_RS24745	COG1960	acyl-CoA dehydrogenase activity
H7K75_RS24750	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7K75_RS24755	COG4770	biotin carboxylase activity
H7K75_RS24765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7K75_RS24770	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H7K75_RS24775	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H7K75_RS24775	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H7K75_RS24800	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H7K75_RS24865	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H7K75_RS24920	COG3750	Belongs to the UPF0335 family
H7K75_RS25010	COG0616	signal peptide processing
H7K75_RS25155	COG1793	dna ligase
H7K75_RS25165	COG2373	Large extracellular alpha-helical protein
H7K75_RS25170	COG4953	penicillin-binding protein 1C
H7K75_RS25180	COG0671	phosphoesterase, PA-phosphatase related
H7K75_RS25185	COG0463	Glycosyl transferase, family 2
H7K75_RS25200	COG1283	sodium-dependent phosphate transmembrane transporter activity
H7K75_RS25205	COG0626	cystathionine gamma-synthase activity
H7K75_RS25210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K75_RS25215	COG4597	amino acid ABC transporter
H7K75_RS25220	COG0765	amino acid transport
H7K75_RS25225	COG1126	abc transporter atp-binding protein
H7K75_RS25260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K75_RS25300	COG1126	abc transporter atp-binding protein
H7K75_RS25315	COG0251	oxidation-reduction process
H7K75_RS25340	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7K75_RS25355	COG0525	valine-tRNA ligase activity
H7K75_RS25360	COG2094	Belongs to the DNA glycosylase MPG family
H7K75_RS25365	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H7K75_RS25370	COG2867	negative regulation of translational initiation
H7K75_RS25375	COG2863	cytochrome
H7K75_RS25380	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7K75_RS25410	COG1058	Belongs to the CinA family
H7K75_RS25410	COG1546	Belongs to the CinA family
H7K75_RS25415	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H7K75_RS25415	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H7K75_RS25435	COG5000	phosphorelay sensor kinase activity
H7K75_RS25440	COG2204	response regulator
H7K75_RS25445	COG1923	regulation of RNA biosynthetic process
H7K75_RS25450	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H7K75_RS25455	COG0454	-acetyltransferase
H7K75_RS25460	COG3956	TIGRFAM MazG family protein
H7K75_RS25465	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H7K75_RS25490	COG0471	metal ion transport
H7K75_RS25495	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H7K75_RS25500	COG2011	ABC-type metal ion transport system permease component
H7K75_RS25510	COG4774	siderophore transport
H7K75_RS25550	COG0006	proline dipeptidase activity
H7K75_RS25555	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H7K75_RS25560	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H7K75_RS25565	COG0318	PFAM AMP-dependent synthetase and ligase
H7K75_RS25570	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H7K75_RS25570	COG0321	lipoyl(octanoyl) transferase activity
H7K75_RS25575	COG0084	hydrolase, TatD family'
H7K75_RS25590	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H7K75_RS25595	COG1686	Belongs to the peptidase S11 family
H7K75_RS25600	COG2267	carboxylic ester hydrolase activity
H7K75_RS25605	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H7K75_RS25650	COG4974	Belongs to the 'phage' integrase family
H7K75_RS25760	COG0129	dihydroxy-acid dehydratase activity
H7K75_RS25780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K75_RS25785	COG0601	transmembrane transport
H7K75_RS25795	COG0444	Belongs to the ABC transporter superfamily
H7K75_RS25815	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H7K75_RS25815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7K75_RS25825	COG1335	isochorismatase
H7K75_RS25860	COG1175	transmembrane transport
H7K75_RS25915	COG0473	3-isopropylmalate dehydrogenase activity
H7K75_RS25915	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7K75_RS25925	COG1984	allophanate hydrolase subunit 2
H7K75_RS25930	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H7K75_RS25940	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7K75_RS25945	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7K75_RS25950	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7K75_RS25955	COG3707	response regulator
H7K75_RS25965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7K75_RS25975	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7K75_RS25980	COG0789	Transcriptional regulator
H7K75_RS26000	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7K75_RS26010	COG1253	flavin adenine dinucleotide binding
H7K75_RS26015	COG1183	phosphatidylcholine synthase activity
H7K75_RS26020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7K75_RS26025	COG0679	Auxin Efflux Carrier
H7K75_RS26065	COG1278	Cold shock
H7K75_RS26075	COG0667	Aldo Keto reductase
H7K75_RS26095	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H7K75_RS26110	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H7K75_RS26125	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H7K75_RS26135	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H7K75_RS26285	COG0459	protein refolding
H7K75_RS26295	COG0071	Belongs to the small heat shock protein (HSP20) family
H7K75_RS26300	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H7K75_RS26300	COG0617	tRNA 3'-terminal CCA addition
H7K75_RS26300	COG0517	IMP dehydrogenase activity
H7K75_RS26305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7K75_RS26315	COG0516	GMP reductase activity
H7K75_RS26315	COG0517	IMP dehydrogenase activity
H7K75_RS26365	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7K75_RS26375	COG0484	heat shock protein binding
H7K75_RS26385	COG0574	Belongs to the PEP-utilizing enzyme family
H7K75_RS26385	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7K75_RS26395	COG2723	6-phospho-beta-galactosidase activity
H7K75_RS26445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H7K75_RS26465	COG0628	permease
H7K75_RS26490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7K75_RS26515	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H7K75_RS26535	COG0697	spore germination
H7K75_RS26585	COG1309	transcriptional regulator
H7K75_RS26595	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H7K75_RS26605	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H7K75_RS26625	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H7K75_RS26635	COG3158	transport of potassium into the cell
H7K75_RS26650	COG0629	single-stranded DNA binding
H7K75_RS26670	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H7K75_RS26685	COG0546	phosphoglycolate phosphatase activity
H7K75_RS26740	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H7K75_RS26795	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
H7K75_RS26805	COG2340	Cysteine-rich secretory protein family
H7K75_RS26820	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H7K75_RS26840	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7K75_RS26845	COG1862	Preprotein translocase
H7K75_RS26855	COG3119	arylsulfatase activity
H7K75_RS26870	COG3119	arylsulfatase activity
H7K75_RS26875	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7K75_RS26880	COG4942	peptidase
H7K75_RS26885	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7K75_RS26895	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H7K75_RS26905	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H7K75_RS26910	COG0805	protein transport
H7K75_RS26915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7K75_RS26920	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7K75_RS26925	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H7K75_RS26930	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H7K75_RS26935	COG1472	Belongs to the glycosyl hydrolase 3 family
H7K75_RS26945	COG0018	arginyl-trna synthetase
H7K75_RS26950	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H7K75_RS26960	COG2198	Histidine kinase
H7K75_RS26960	COG0784	Response regulator, receiver
H7K75_RS26960	COG5002	protein histidine kinase activity
H7K75_RS26965	COG0708	Exodeoxyribonuclease III
H7K75_RS26970	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
H7K75_RS26975	COG0129	dihydroxy-acid dehydratase activity
H7K75_RS26985	COG4206	TonB-dependent receptor
H7K75_RS27035	COG4191	Histidine kinase
H7K75_RS27040	COG4566	intracellular signal transduction
H7K75_RS27045	COG4566	intracellular signal transduction
H7K75_RS27055	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7K75_RS27060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7K75_RS27070	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7K75_RS27085	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7K75_RS27085	COG0022	dehydrogenase e1 component
H7K75_RS27090	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H7K75_RS27095	COG1012	belongs to the aldehyde dehydrogenase family
H7K75_RS27110	COG0431	NADPH-dependent FMN reductase
H7K75_RS27120	COG1917	Cupin 2, conserved barrel domain protein
H7K75_RS27120	COG4977	sequence-specific DNA binding
H7K75_RS27145	COG0148	phosphopyruvate hydratase activity
H7K75_RS27155	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H7K75_RS27165	COG2066	Belongs to the glutaminase family
H7K75_RS27165	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
H7K75_RS27175	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H7K75_RS27185	COG0745	RESPONSE REGULATOR receiver
H7K75_RS27190	COG2205	protein histidine kinase activity
H7K75_RS27195	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H7K75_RS27200	COG0504	CTP synthase activity
H7K75_RS27210	COG0149	triose-phosphate isomerase activity
H7K75_RS27215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7K75_RS27220	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H7K75_RS27225	COG0134	indole-3-glycerol-phosphate synthase activity
H7K75_RS27230	COG0315	cyclic pyranopterin monophosphate synthase activity
H7K75_RS27240	COG5001	Diguanylate cyclase
H7K75_RS27240	COG3300	MHYT domain
H7K75_RS27295	COG0793	Belongs to the peptidase S41A family
H7K75_RS27300	COG1304	FMN binding
H7K75_RS27305	COG1011	Hydrolase
H7K75_RS27320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H7K75_RS27350	COG0477	Major facilitator Superfamily
H7K75_RS27375	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7K75_RS27380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7K75_RS27385	COG0372	Belongs to the citrate synthase family
H7K75_RS27405	COG1175	transmembrane transport
H7K75_RS27410	COG0395	ABC-type sugar transport system, permease component
H7K75_RS27420	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS27440	COG3069	C4-dicarboxylate transmembrane transporter activity
H7K75_RS27465	COG1802	Transcriptional regulator
H7K75_RS27470	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7K75_RS27480	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7K75_RS27490	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7K75_RS27495	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7K75_RS27500	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7K75_RS27505	COG0750	zinc metalloprotease
H7K75_RS27510	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H7K75_RS27520	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H7K75_RS27525	COG0233	cytoplasmic translational termination
H7K75_RS27530	COG0528	UMP kinase activity
H7K75_RS27535	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H7K75_RS27540	COG0052	Belongs to the universal ribosomal protein uS2 family
H7K75_RS27560	COG0288	reversible hydration of carbon dioxide
H7K75_RS27590	COG2814	Major facilitator Superfamily
H7K75_RS27595	COG0024	Methionine aminopeptidase
H7K75_RS27615	COG1136	(ABC) transporter
H7K75_RS27625	COG0442	prolyl-tRNA aminoacylation
H7K75_RS27665	COG1129	ABC transporter
H7K75_RS27670	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7K75_RS27680	COG0251	oxidation-reduction process
H7K75_RS27685	COG0583	DNA-binding transcription factor activity
H7K75_RS27705	COG4608	Belongs to the ABC transporter superfamily
H7K75_RS27710	COG0444	Belongs to the ABC transporter superfamily
H7K75_RS27715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K75_RS27750	COG0346	lactoylglutathione lyase activity
H7K75_RS27765	COG1007	ATP synthesis coupled electron transport
H7K75_RS27780	COG0713	ATP synthesis coupled electron transport
H7K75_RS27790	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7K75_RS27795	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H7K75_RS27805	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H7K75_RS27815	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H7K75_RS27825	COG0649	NAD binding
H7K75_RS27835	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7K75_RS27850	COG4774	siderophore transport
H7K75_RS27865	COG2814	Major facilitator Superfamily
H7K75_RS27875	COG0653	protein targeting
H7K75_RS27890	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7K75_RS27900	COG1595	DNA-templated transcription, initiation
H7K75_RS27925	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K75_RS27950	COG1230	cation diffusion facilitator family transporter
H7K75_RS27960	COG2755	lipolytic protein G-D-S-L family
H7K75_RS27960	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H7K75_RS27975	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H7K75_RS27980	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H7K75_RS27985	COG0740	serine-type endopeptidase activity
H7K75_RS27990	COG0544	peptidyl-prolyl cis-trans isomerase activity
H7K75_RS28010	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H7K75_RS28010	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H7K75_RS28015	COG0347	Belongs to the P(II) protein family
H7K75_RS28020	COG0174	glutamine synthetase
H7K75_RS28025	COG0252	asparaginase activity
H7K75_RS28030	COG0330	HflC and HflK could
H7K75_RS28050	COG3038	cytochrome b561
H7K75_RS28060	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H7K75_RS28085	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H7K75_RS28090	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H7K75_RS28100	COG1024	Enoyl-CoA hydratase
H7K75_RS28120	COG1612	heme a metabolic process
H7K75_RS28145	COG0438	transferase activity, transferring glycosyl groups
H7K75_RS28160	COG1846	Transcriptional regulator
H7K75_RS28165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7K75_RS28170	COG3268	Saccharopine dehydrogenase
H7K75_RS28230	COG0657	acetylesterase activity
H7K75_RS28240	COG0135	phosphoribosylanthranilate isomerase activity
H7K75_RS28300	COG0776	regulation of translation
H7K75_RS28305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7K75_RS28310	COG0416	fatty acid biosynthetic process
H7K75_RS28335	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H7K75_RS28340	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H7K75_RS28345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7K75_RS28350	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H7K75_RS28360	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7K75_RS28360	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7K75_RS28365	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H7K75_RS28370	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H7K75_RS28395	COG0113	porphobilinogen synthase activity
H7K75_RS28405	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H7K75_RS28430	COG1914	H( )-stimulated, divalent metal cation uptake system
H7K75_RS28440	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H7K75_RS28460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7K75_RS28475	COG2059	Chromate
H7K75_RS28495	COG0747	negative chemotaxis
H7K75_RS28500	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H7K75_RS28510	COG1381	Involved in DNA repair and RecF pathway recombination
H7K75_RS28520	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H7K75_RS28525	COG0571	ribonuclease III activity
H7K75_RS28530	COG0681	Belongs to the peptidase S26 family
H7K75_RS28535	COG0736	holo-[acyl-carrier-protein] synthase activity
H7K75_RS28540	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H7K75_RS28550	COG1758	RNA polymerase activity
H7K75_RS28570	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H7K75_RS28575	COG1970	mechanosensitive ion channel activity
H7K75_RS28580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7K75_RS28585	COG0741	lytic transglycosylase activity
H7K75_RS28590	COG3119	arylsulfatase activity
H7K75_RS28595	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7K75_RS28620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K75_RS28645	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H7K75_RS28655	COG0154	amidase activity
H7K75_RS28665	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H7K75_RS28670	COG2070	2-Nitropropane dioxygenase
H7K75_RS28680	COG0583	DNA-binding transcription factor activity
H7K75_RS28690	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H7K75_RS28700	COG3415	Transposase
H7K75_RS28700	COG2801	Transposase and inactivated derivatives
H7K75_RS28710	COG1960	acyl-CoA dehydrogenase activity
H7K75_RS28720	COG0540	Belongs to the ATCase OTCase family
H7K75_RS28730	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H7K75_RS28740	COG0154	amidase activity
H7K75_RS28745	COG0758	DNA mediated transformation
H7K75_RS28750	COG1733	regulation of RNA biosynthetic process
H7K75_RS28755	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7K75_RS28765	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS28775	COG0655	NAD(P)H dehydrogenase (quinone) activity
H7K75_RS28785	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H7K75_RS28790	COG0557	exoribonuclease II activity
H7K75_RS28815	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H7K75_RS28845	COG0784	Response regulator, receiver
H7K75_RS28855	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7K75_RS28870	COG0494	nUDIX hydrolase
H7K75_RS28900	COG0537	adenosine 5'-monophosphoramidase activity
H7K75_RS28905	COG1720	tRNA m6t6A37 methyltransferase activity
H7K75_RS28950	COG1482	cell wall glycoprotein biosynthetic process
H7K75_RS28985	COG0667	Aldo Keto reductase
H7K75_RS28995	COG2814	Major facilitator Superfamily
H7K75_RS29025	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H7K75_RS29040	COG1686	Belongs to the peptidase S11 family
H7K75_RS29050	COG1275	C4-dicarboxylate transporter malic acid transport protein
H7K75_RS29065	COG1192	Involved in chromosome partitioning
H7K75_RS29070	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H7K75_RS29115	COG0656	L-ascorbic acid biosynthetic process
H7K75_RS29125	COG2239	Acts as a magnesium transporter
H7K75_RS29165	COG0321	lipoyl(octanoyl) transferase activity
H7K75_RS29170	COG0305	Participates in initiation and elongation during chromosome replication
H7K75_RS29185	COG1090	epimerase
H7K75_RS29205	COG1254	Belongs to the acylphosphatase family
H7K75_RS29210	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H7K75_RS29215	COG4770	biotin carboxylase activity
H7K75_RS29250	COG2271	Major facilitator Superfamily
H7K75_RS29260	COG4948	Mandelate Racemase Muconate Lactonizing
H7K75_RS29265	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS29270	COG1063	alcohol dehydrogenase
H7K75_RS29285	COG2197	response regulator
H7K75_RS29295	COG1414	Transcriptional regulator
H7K75_RS29300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7K75_RS29305	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7K75_RS29350	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS29390	COG4566	intracellular signal transduction
H7K75_RS29395	COG1566	PFAM secretion protein HlyD family protein
H7K75_RS29400	COG0577	efflux transmembrane transporter activity
H7K75_RS29400	COG1136	(ABC) transporter
H7K75_RS29405	COG1136	(ABC) transporter
H7K75_RS29405	COG0577	efflux transmembrane transporter activity
H7K75_RS29425	COG0450	alkyl hydroperoxide reductase
H7K75_RS29435	COG0415	Belongs to the DNA photolyase family
H7K75_RS29535	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS29540	COG2030	dehydratase
H7K75_RS29570	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7K75_RS29570	COG2010	Cytochrome c
H7K75_RS29575	COG2860	membrane
H7K75_RS29635	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7K75_RS29640	COG3360	Dodecin
H7K75_RS29670	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7K75_RS29695	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H7K75_RS29720	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H7K75_RS29735	COG1733	regulation of RNA biosynthetic process
H7K75_RS29750	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS29755	COG3181	Tripartite tricarboxylate transporter family receptor
H7K75_RS29760	COG0203	ribosomal protein L17
H7K75_RS29765	COG0202	RNA polymerase activity
H7K75_RS29770	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H7K75_RS29775	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H7K75_RS29780	COG0563	adenylate kinase activity
H7K75_RS29790	COG0200	Binds to the 23S rRNA
H7K75_RS29795	COG1841	ribosomal large subunit assembly
H7K75_RS29800	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H7K75_RS29805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H7K75_RS29810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H7K75_RS29815	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H7K75_RS29820	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H7K75_RS29825	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H7K75_RS29830	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H7K75_RS29835	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H7K75_RS29840	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H7K75_RS29845	COG0255	Belongs to the universal ribosomal protein uL29 family
H7K75_RS29850	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H7K75_RS29855	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H7K75_RS29860	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H7K75_RS29865	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H7K75_RS29870	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H7K75_RS29875	COG0089	rRNA binding
H7K75_RS29880	COG0088	Forms part of the polypeptide exit tunnel
H7K75_RS29885	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H7K75_RS29890	COG0051	transcription antitermination factor activity, RNA binding
H7K75_RS29895	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7K75_RS29900	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H7K75_RS29905	COG0049	tRNA binding
H7K75_RS29910	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H7K75_RS29920	COG1132	(ABC) transporter
H7K75_RS29925	COG1231	oxidoreductase activity
H7K75_RS29930	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H7K75_RS29935	COG0085	RNA polymerase activity
H7K75_RS29940	COG0222	ribosome binding
H7K75_RS29945	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H7K75_RS29950	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7K75_RS29955	COG0081	regulation of translation
H7K75_RS29960	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H7K75_RS29965	COG0250	Participates in transcription elongation, termination and antitermination
H7K75_RS29970	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H7K75_RS29990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7K75_RS29995	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H7K75_RS29995	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H7K75_RS30000	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7K75_RS30015	COG3959	Transketolase, thiamine diphosphate binding domain
H7K75_RS30020	COG3958	Transketolase
H7K75_RS30045	COG2226	methyltransferase
H7K75_RS30065	COG0673	inositol 2-dehydrogenase activity
H7K75_RS30100	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS30110	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS30130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7K75_RS30135	COG1280	lysine exporter protein (LysE YggA)
H7K75_RS30155	COG1960	acyl-CoA dehydrogenase activity
H7K75_RS30175	COG3246	L-lysine catabolic process to acetate
H7K75_RS30180	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7K75_RS30190	COG3246	L-lysine catabolic process to acetate
H7K75_RS30210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7K75_RS30230	COG2274	protein secretion by the type I secretion system
H7K75_RS30275	COG0437	4 iron, 4 sulfur cluster binding
H7K75_RS30345	COG0784	Response regulator, receiver
H7K75_RS30345	COG4191	Histidine kinase
H7K75_RS30365	COG3795	YCII-related domain
H7K75_RS30375	COG0210	DNA helicase
H7K75_RS30380	COG0402	S-adenosylhomocysteine deaminase activity
H7K75_RS30390	COG0477	Major facilitator Superfamily
H7K75_RS30410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7K75_RS30515	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H7K75_RS30540	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H7K75_RS30545	COG0302	gtp cyclohydrolase
H7K75_RS30560	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H7K75_RS30580	COG0477	Major facilitator Superfamily
H7K75_RS30620	COG2814	Major facilitator Superfamily
H7K75_RS30625	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H7K75_RS30630	COG5295	Hep Hag repeat protein
H7K75_RS30650	COG5001	Diguanylate cyclase
H7K75_RS30660	COG0604	alcohol dehydrogenase
H7K75_RS30660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7K75_RS30660	COG4221	oxidoreductase activity
H7K75_RS30660	COG3321	synthase
H7K75_RS30670	COG0667	Aldo Keto reductase
H7K75_RS30685	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7K75_RS30690	COG0517	IMP dehydrogenase activity
H7K75_RS30770	COG1063	alcohol dehydrogenase
H7K75_RS30790	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H7K75_RS30805	COG3842	ATPase activity
H7K75_RS30815	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7K75_RS30820	COG3833	ABC-type maltose transport systems, permease component
H7K75_RS30885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7K75_RS30900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7K75_RS30920	COG2814	Major facilitator Superfamily
H7K75_RS30930	COG0747	negative chemotaxis
H7K75_RS30940	COG0601	transmembrane transport
H7K75_RS30945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K75_RS30950	COG4172	Belongs to the ABC transporter superfamily
H7K75_RS30960	COG1473	amidohydrolase
H7K75_RS30965	COG0154	amidase activity
H7K75_RS30970	COG1024	Enoyl-CoA hydratase
H7K75_RS30975	COG3321	synthase
H7K75_RS30975	COG0604	alcohol dehydrogenase
H7K75_RS30985	COG0625	glutathione transferase activity
H7K75_RS31000	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H7K75_RS31005	COG1058	Belongs to the CinA family
H7K75_RS31005	COG1546	Belongs to the CinA family
H7K75_RS31010	COG2308	Evidence 4 Homologs of previously reported genes of
H7K75_RS31040	COG4221	oxidoreductase activity
H7K75_RS31055	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7K75_RS31070	COG5425	PFAM Usg family protein
H7K75_RS31075	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H7K75_RS31080	COG0459	protein refolding
H7K75_RS31090	COG0681	Belongs to the peptidase S26 family
H7K75_RS31115	COG1335	isochorismatase
H7K75_RS31180	COG0384	phenazine biosynthesis protein PhzF
H7K75_RS31190	COG2814	Major facilitator Superfamily
H7K75_RS31195	COG2188	Transcriptional regulator
H7K75_RS31210	COG0842	Transport permease protein
H7K75_RS31215	COG1131	(ABC) transporter
H7K75_RS31225	COG1309	transcriptional regulator
H7K75_RS31230	COG0640	Transcriptional regulator
H7K75_RS31270	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H7K75_RS31270	COG3608	succinylglutamate desuccinylase aspartoacylase
H7K75_RS31305	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H7K75_RS31310	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7K75_RS31315	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7K75_RS31355	COG2204	response regulator
H7K75_RS31360	COG4191	Histidine kinase
H7K75_RS31360	COG0784	Response regulator, receiver
H7K75_RS31395	COG0515	serine threonine protein kinase
H7K75_RS31395	COG2815	serine threonine protein kinase
H7K75_RS31435	COG1309	transcriptional regulator
H7K75_RS31440	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H7K75_RS31445	COG1473	amidohydrolase
H7K75_RS31475	COG0318	PFAM AMP-dependent synthetase and ligase
H7K75_RS31480	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7K75_RS31520	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H7K75_RS31540	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H7K75_RS31545	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H7K75_RS31550	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7K75_RS31555	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
H7K75_RS31585	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H7K75_RS31605	COG0047	phosphoribosylformylglycinamidine synthase activity
H7K75_RS31610	COG0598	Magnesium transport protein CorA
H7K75_RS31615	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H7K75_RS31620	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H7K75_RS31630	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
H7K75_RS31635	COG1116	anion transmembrane transporter activity
H7K75_RS31635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7K75_RS31640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K75_RS31645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7K75_RS31670	COG1309	transcriptional regulator
H7K75_RS31680	COG2020	methyltransferase activity
H7K75_RS31685	COG0604	alcohol dehydrogenase
H7K75_RS31705	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H7K75_RS31710	COG0538	isocitrate dehydrogenase activity
H7K75_RS31720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7K75_RS31725	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H7K75_RS31730	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H7K75_RS31735	COG0509	glycine decarboxylation via glycine cleavage system
H7K75_RS31740	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7K75_RS31740	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7K75_RS31750	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H7K75_RS31850	COG0640	Transcriptional regulator
H7K75_RS31905	COG1879	ABC-type sugar transport system periplasmic component
H7K75_RS31910	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7K75_RS31920	COG1070	Carbohydrate kinase
H7K75_RS31965	COG2917	probably involved in intracellular septation
H7K75_RS31980	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H7K75_RS31980	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H7K75_RS32015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K75_RS32050	COG1684	flagellar biosynthetic protein fliR
H7K75_RS32055	COG1987	bacterial-type flagellum assembly
H7K75_RS32060	COG1677	Flagellar hook-basal body complex protein FliE
H7K75_RS32065	COG1558	bacterial-type flagellum-dependent cell motility
H7K75_RS32080	COG1338	Plays a role in the flagellum-specific transport system
H7K75_RS32130	COG4786	Flagellar basal body rod
H7K75_RS32135	COG4786	Flagellar basal body rod
H7K75_RS32145	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H7K75_RS32150	COG3971	2-oxopent-4-enoate hydratase activity
H7K75_RS32160	COG1733	regulation of RNA biosynthetic process
H7K75_RS32190	COG1566	PFAM secretion protein HlyD family protein
H7K75_RS32210	COG3119	arylsulfatase activity
H7K75_RS32215	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7K75_RS32255	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H7K75_RS32290	COG0438	transferase activity, transferring glycosyl groups
H7K75_RS32305	COG0071	Belongs to the small heat shock protein (HSP20) family
H7K75_RS32310	COG0071	Belongs to the small heat shock protein (HSP20) family
H7K75_RS32315	COG0071	Belongs to the small heat shock protein (HSP20) family
H7K75_RS32335	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H7K75_RS32340	COG0459	protein refolding
H7K75_RS32350	COG0071	Belongs to the small heat shock protein (HSP20) family
H7K75_RS32355	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7K75_RS32360	COG0071	Belongs to the small heat shock protein (HSP20) family
H7K75_RS32365	COG0071	Belongs to the small heat shock protein (HSP20) family
H7K75_RS32370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7K75_RS32405	COG2910	NAD(P)H-binding
H7K75_RS32410	COG1733	regulation of RNA biosynthetic process
H7K75_RS32420	COG1706	bacterial-type flagellum-dependent cell motility
H7K75_RS32440	COG5442	Flagellar protein FlaF
H7K75_RS32445	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7K75_RS32450	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7K75_RS32455	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7K75_RS32460	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7K75_RS32465	COG5443	negative regulation of bacterial-type flagellum assembly
H7K75_RS32470	COG0076	glutamate decarboxylase activity
H7K75_RS32495	COG1256	bacterial-type flagellum assembly
H7K75_RS32500	COG1749	Flagellar hook protein flgE
H7K75_RS32505	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7K75_RS32510	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H7K75_RS32510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K75_RS32530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7K75_RS32550	COG3300	MHYT domain
H7K75_RS32550	COG5001	Diguanylate cyclase
H7K75_RS32555	COG0477	Major facilitator Superfamily
H7K75_RS32560	COG3685	Protein conserved in bacteria
H7K75_RS32575	COG3415	Transposase
H7K75_RS32575	COG2801	Transposase and inactivated derivatives
H7K75_RS32580	COG2271	Major facilitator Superfamily
H7K75_RS32585	COG0583	DNA-binding transcription factor activity
H7K75_RS32590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7K75_RS32600	COG1012	belongs to the aldehyde dehydrogenase family
H7K75_RS32605	COG2721	sulfolactate sulfo-lyase activity
H7K75_RS32620	COG0745	RESPONSE REGULATOR receiver
H7K75_RS32625	COG2205	protein histidine kinase activity
H7K75_RS32650	COG0492	ferredoxin-NADP+ reductase activity
H7K75_RS32660	COG0633	Ferredoxin
H7K75_RS32680	COG0784	Response regulator, receiver
H7K75_RS32680	COG2205	protein histidine kinase activity
H7K75_RS32695	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7K75_RS32695	COG3218	ABC-type transport auxiliary lipoprotein component
H7K75_RS32700	COG1127	ABC transporter
H7K75_RS32705	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H7K75_RS32710	COG4948	Mandelate Racemase Muconate Lactonizing
H7K75_RS32715	COG2814	Major facilitator Superfamily
H7K75_RS32735	COG4154	Belongs to the RbsD FucU family
H7K75_RS32760	COG0351	phosphomethylpyrimidine kinase
H7K75_RS32765	COG4191	Histidine kinase
H7K75_RS32765	COG0784	Response regulator, receiver
H7K75_RS32775	COG2010	Cytochrome c
H7K75_RS32795	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H7K75_RS32800	COG3909	cytochrome
H7K75_RS32810	COG0456	acetyltransferase
H7K75_RS32830	COG0673	inositol 2-dehydrogenase activity
H7K75_RS32835	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H7K75_RS32835	COG0662	Cupin 2, conserved barrel domain protein
H7K75_RS32850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H7K75_RS32870	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H7K75_RS32870	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H7K75_RS32880	COG0859	PFAM glycosyl transferase family 9
H7K75_RS32895	COG1132	(ABC) transporter
H7K75_RS32920	COG0583	DNA-binding transcription factor activity
H7K75_RS32925	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS32930	COG1942	4-Oxalocrotonate Tautomerase
H7K75_RS32945	COG0489	protein tyrosine kinase activity
H7K75_RS32960	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H7K75_RS32965	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H7K75_RS32980	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H7K75_RS33050	COG0318	PFAM AMP-dependent synthetase and ligase
H7K75_RS33055	COG0559	Belongs to the binding-protein-dependent transport system permease family
H7K75_RS33075	COG2942	2-epimerase
H7K75_RS33090	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H7K75_RS33095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7K75_RS33125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7K75_RS33145	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H7K75_RS33155	COG1215	transferase activity, transferring glycosyl groups
H7K75_RS33165	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H7K75_RS33170	COG1216	Glycosyl transferase, family 2
H7K75_RS33170	COG0438	transferase activity, transferring glycosyl groups
H7K75_RS33190	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7K75_RS33195	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H7K75_RS33225	COG0438	transferase activity, transferring glycosyl groups
H7K75_RS33230	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
H7K75_RS33240	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7K75_RS33260	COG3181	Tripartite tricarboxylate transporter family receptor
H7K75_RS33270	COG1024	Enoyl-CoA hydratase
H7K75_RS33275	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H7K75_RS33280	COG2271	Major facilitator Superfamily
H7K75_RS33285	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H7K75_RS33290	COG1802	Transcriptional regulator
H7K75_RS33295	COG0277	FAD linked oxidase domain protein
H7K75_RS33295	COG0247	lactate metabolic process
H7K75_RS33360	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H7K75_RS33430	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H7K75_RS33440	COG3181	Tripartite tricarboxylate transporter family receptor
H7K75_RS33445	COG2080	2 iron, 2 sulfur cluster binding
H7K75_RS33450	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7K75_RS33450	COG2010	Cytochrome c
H7K75_RS33460	COG0516	GMP reductase activity
H7K75_RS33460	COG0517	IMP dehydrogenase activity
H7K75_RS33475	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS33490	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H7K75_RS33505	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
H7K75_RS33515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7K75_RS33520	COG2010	Cytochrome c
H7K75_RS33525	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7K75_RS33525	COG3218	ABC-type transport auxiliary lipoprotein component
H7K75_RS33530	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H7K75_RS33550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7K75_RS33550	COG1042	CoA-binding domain protein
H7K75_RS33550	COG0045	succinate-CoA ligase (ADP-forming) activity
H7K75_RS33575	COG3243	poly(R)-hydroxyalkanoic acid synthase
H7K75_RS33580	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H7K75_RS33580	COG0617	tRNA 3'-terminal CCA addition
H7K75_RS33580	COG0517	IMP dehydrogenase activity
H7K75_RS33585	COG0251	oxidation-reduction process
H7K75_RS33615	COG1024	Enoyl-CoA hydratase
H7K75_RS33620	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS33630	COG1960	acyl-CoA dehydrogenase activity
H7K75_RS33635	COG0318	PFAM AMP-dependent synthetase and ligase
H7K75_RS33645	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7K75_RS33655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K75_RS33660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K75_RS33670	COG0129	dihydroxy-acid dehydratase activity
H7K75_RS33715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7K75_RS33750	COG3547	Transposase (IS116 IS110 IS902 family)
H7K75_RS33815	COG4948	Mandelate Racemase Muconate Lactonizing
H7K75_RS33825	COG3258	Cytochrome c
H7K75_RS33835	COG0010	Belongs to the arginase family
H7K75_RS33845	COG3300	MHYT domain
H7K75_RS33845	COG5001	Diguanylate cyclase
H7K75_RS33865	COG2010	Cytochrome c
H7K75_RS33940	COG2252	PERMEase
H7K75_RS33945	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H7K75_RS33955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7K75_RS33960	COG1301	dicarboxylic acid transport
H7K75_RS33980	COG1079	Belongs to the binding-protein-dependent transport system permease family
H7K75_RS33985	COG1079	Belongs to the binding-protein-dependent transport system permease family
H7K75_RS33995	COG3845	ABC transporter
H7K75_RS34010	COG3845	ABC transporter
H7K75_RS34015	COG4603	Belongs to the binding-protein-dependent transport system permease family
H7K75_RS34020	COG1079	Belongs to the binding-protein-dependent transport system permease family
H7K75_RS34040	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7K75_RS34040	COG2080	2 iron, 2 sulfur cluster binding
H7K75_RS34045	COG2233	PERMEase
H7K75_RS34090	COG0235	Class ii aldolase
H7K75_RS34095	COG2095	MarC family integral membrane protein
H7K75_RS34110	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H7K75_RS34120	COG0776	regulation of translation
H7K75_RS34125	COG0183	Belongs to the thiolase family
H7K75_RS34130	COG2723	6-phospho-beta-galactosidase activity
H7K75_RS34170	COG4771	TonB-dependent receptor
H7K75_RS34180	COG2197	response regulator
H7K75_RS34185	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H7K75_RS34205	COG1131	(ABC) transporter
H7K75_RS34340	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H7K75_RS34345	COG3791	Glutathione-dependent formaldehyde-activating
H7K75_RS34365	COG0723	plastoquinol--plastocyanin reductase activity
H7K75_RS34375	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7K75_RS34380	COG0277	FAD linked oxidase domain protein
H7K75_RS34385	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7K75_RS34420	COG5001	Diguanylate cyclase
H7K75_RS34420	COG3300	MHYT domain
H7K75_RS34465	COG1309	transcriptional regulator
H7K75_RS34470	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H7K75_RS34475	COG2986	histidine ammonia-lyase
H7K75_RS34480	COG1228	amidohydrolase
H7K75_RS34485	COG1228	amidohydrolase
H7K75_RS34500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K75_RS34505	COG1116	anion transmembrane transporter activity
H7K75_RS34515	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7K75_RS34525	COG1917	Cupin 2, conserved barrel domain protein
H7K75_RS34525	COG4977	sequence-specific DNA binding
H7K75_RS34530	COG2223	nitrite transmembrane transporter activity
H7K75_RS34545	COG0656	L-ascorbic acid biosynthetic process
H7K75_RS34555	COG1566	PFAM secretion protein HlyD family protein
H7K75_RS34565	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7K75_RS34575	COG1764	response to oxidative stress
H7K75_RS34585	COG0596	Alpha beta hydrolase
H7K75_RS34620	COG2267	carboxylic ester hydrolase activity
H7K75_RS34625	COG2169	Transcriptional regulator
H7K75_RS34635	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H7K75_RS34655	COG1802	Transcriptional regulator
H7K75_RS34670	COG2124	cytochrome p450
H7K75_RS34680	COG2873	o-acetylhomoserine
H7K75_RS34685	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H7K75_RS34695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7K75_RS34700	COG0318	PFAM AMP-dependent synthetase and ligase
H7K75_RS34715	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS34725	COG2197	response regulator
H7K75_RS34730	COG2197	response regulator
H7K75_RS34795	COG0297	glycogen (starch) synthase activity
H7K75_RS34840	COG0367	asparagine synthase
H7K75_RS34850	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7K75_RS34895	COG2963	transposase activity
H7K75_RS34900	COG3436	PFAM IS66 Orf2 family protein
H7K75_RS34905	COG4372	Transposase
H7K75_RS34915	COG3436	PFAM IS66 Orf2 family protein
H7K75_RS34940	COG3436	PFAM IS66 Orf2 family protein
H7K75_RS34945	COG2963	transposase activity
H7K75_RS34985	COG3328	transposase activity
H7K75_RS34990	COG3328	transposase activity
H7K75_RS34995	COG4372	Transposase
H7K75_RS35000	COG4372	Transposase
H7K75_RS35010	COG2192	nodulation
H7K75_RS35040	COG1596	polysaccharide export
H7K75_RS35045	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7K75_RS35085	COG1012	belongs to the aldehyde dehydrogenase family
H7K75_RS35090	COG2084	Dehydrogenase
H7K75_RS35095	COG1129	ABC transporter
H7K75_RS35105	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7K75_RS35125	COG1522	sequence-specific DNA binding
H7K75_RS35170	COG0651	ATP synthesis coupled electron transport
H7K75_RS35185	COG0651	ATP synthesis coupled electron transport
H7K75_RS35190	COG0649	NAD binding
H7K75_RS35195	COG3260	NADH ubiquinone oxidoreductase 20
H7K75_RS35300	COG0582	viral genome integration into host DNA
H7K75_RS35330	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7K75_RS35345	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7K75_RS35360	COG0559	Belongs to the binding-protein-dependent transport system permease family
H7K75_RS35385	COG0673	inositol 2-dehydrogenase activity
H7K75_RS35390	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H7K75_RS35400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7K75_RS35405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7K75_RS35410	COG1960	acyl-CoA dehydrogenase activity
H7K75_RS35415	COG1116	anion transmembrane transporter activity
H7K75_RS35435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7K75_RS35445	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H7K75_RS35450	COG0297	glycogen (starch) synthase activity
H7K75_RS35455	COG4095	Psort location CytoplasmicMembrane, score
H7K75_RS35465	COG3384	dioxygenase
H7K75_RS35485	COG2072	flavoprotein involved in K transport
H7K75_RS35505	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H7K75_RS35510	COG0281	malic enzyme
H7K75_RS35520	COG0668	transmembrane transport
H7K75_RS35535	COG2326	polyphosphate kinase activity
H7K75_RS35600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K75_RS35610	COG0517	IMP dehydrogenase activity
H7K75_RS35610	COG1125	glycine betaine transport
H7K75_RS35615	COG1174	glycine betaine transport
H7K75_RS35635	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS35645	COG3300	MHYT domain
H7K75_RS35645	COG5001	Diguanylate cyclase
H7K75_RS35650	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H7K75_RS35670	COG0440	acetolactate synthase activity
H7K75_RS35680	COG0028	Belongs to the TPP enzyme family
H7K75_RS35685	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H7K75_RS35705	COG0330	HflC and HflK could
H7K75_RS35710	COG0330	HflC and HflK could
H7K75_RS35725	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H7K75_RS35765	COG0114	fumarate hydratase activity
H7K75_RS35815	COG1309	transcriptional regulator
H7K75_RS35820	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS35850	COG1309	transcriptional regulator
H7K75_RS35900	COG2202	Pas domain
H7K75_RS35900	COG2200	EAL domain
H7K75_RS35900	COG2199	diguanylate cyclase activity
H7K75_RS35905	COG2271	Major facilitator Superfamily
H7K75_RS35910	COG3300	MHYT domain
H7K75_RS35910	COG5001	Diguanylate cyclase
H7K75_RS35920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7K75_RS35925	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H7K75_RS35930	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H7K75_RS35940	COG2259	Doxx family
H7K75_RS35945	COG0583	DNA-binding transcription factor activity
H7K75_RS35970	COG0277	FAD linked oxidase domain protein
H7K75_RS35980	COG5487	UPF0391 membrane protein
H7K75_RS35985	COG0210	DNA helicase
H7K75_RS36005	COG1088	dTDP-glucose 4,6-dehydratase activity
H7K75_RS36020	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
H7K75_RS36040	COG0071	Belongs to the small heat shock protein (HSP20) family
H7K75_RS36065	COG2267	carboxylic ester hydrolase activity
H7K75_RS36075	COG1131	(ABC) transporter
H7K75_RS36080	COG0842	Transport permease protein
H7K75_RS36100	COG0584	glycerophosphoryl diester phosphodiesterase
H7K75_RS36120	COG2264	protein methyltransferase activity
H7K75_RS36130	COG0006	proline dipeptidase activity
H7K75_RS36130	COG0006	proline dipeptidase activity
H7K75_RS36135	COG2814	Major facilitator Superfamily
H7K75_RS36140	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H7K75_RS36150	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7K75_RS36160	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H7K75_RS36165	COG0849	cell division
H7K75_RS36170	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H7K75_RS36175	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7K75_RS36180	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H7K75_RS36185	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7K75_RS36190	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H7K75_RS36200	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H7K75_RS36205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H7K75_RS36210	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H7K75_RS36215	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H7K75_RS36230	COG0275	rRNA processing
H7K75_RS36235	COG3023	N-Acetylmuramoyl-L-alanine amidase
H7K75_RS36240	COG4941	Belongs to the sigma-70 factor family
H7K75_RS36245	COG3795	YCII-related domain
H7K75_RS36265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7K75_RS36285	COG5265	(ABC) transporter
H7K75_RS36300	COG1309	transcriptional regulator
H7K75_RS36340	COG0688	phosphatidylethanolamine metabolic process
H7K75_RS36365	COG1388	LysM domain
H7K75_RS36365	COG1376	ErfK ybiS ycfS ynhG family protein
H7K75_RS36370	COG3474	cytochrome
H7K75_RS36415	COG3842	ATPase activity
H7K75_RS36425	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7K75_RS36480	COG2022	thiamine diphosphate biosynthetic process
H7K75_RS36490	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H7K75_RS36510	COG0625	glutathione transferase activity
H7K75_RS36550	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS36555	COG2204	response regulator
H7K75_RS36580	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7K75_RS36595	COG2193	ferroxidase activity
H7K75_RS36635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7K75_RS36640	COG1376	ErfK ybiS ycfS ynhG family protein
H7K75_RS36650	COG2897	thiosulfate sulfurtransferase activity
H7K75_RS36655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7K75_RS36670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7K75_RS36675	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H7K75_RS36690	COG2207	Transcriptional regulator
H7K75_RS36690	COG3708	Transcriptional regulator
H7K75_RS36695	COG4948	Mandelate Racemase Muconate Lactonizing
H7K75_RS36720	COG2203	Gaf domain
H7K75_RS36720	COG3706	GGDEF domain
H7K75_RS36720	COG4251	negative regulation of phosphorylation
H7K75_RS36720	COG5001	Diguanylate cyclase
H7K75_RS36735	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H7K75_RS36735	COG1672	PFAM Archaeal ATPase
H7K75_RS36745	COG4172	Belongs to the ABC transporter superfamily
H7K75_RS36750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7K75_RS36755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K75_RS36760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K75_RS36765	COG0601	transmembrane transport
H7K75_RS36770	COG0747	negative chemotaxis
H7K75_RS36780	COG4191	Histidine kinase
H7K75_RS36780	COG0784	Response regulator, receiver
H7K75_RS36795	COG1231	oxidoreductase activity
H7K75_RS36855	COG4948	Mandelate Racemase Muconate Lactonizing
H7K75_RS36865	COG0386	Belongs to the glutathione peroxidase family
H7K75_RS36870	COG0154	amidase activity
H7K75_RS36885	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H7K75_RS36890	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
H7K75_RS36895	COG0535	radical SAM domain protein
H7K75_RS36900	COG0535	radical SAM domain protein
H7K75_RS36915	COG0493	'glutamate synthase
H7K75_RS36920	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H7K75_RS36920	COG0674	pyruvate-flavodoxin oxidoreductase activity
H7K75_RS36925	COG1013	pyruvate-flavodoxin oxidoreductase activity
H7K75_RS36980	COG2719	SpoVR family
H7K75_RS36985	COG2718	Belongs to the UPF0229 family
H7K75_RS36990	COG2766	serine protein kinase
H7K75_RS37000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7K75_RS37005	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H7K75_RS37010	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H7K75_RS37015	COG0363	glucosamine-6-phosphate deaminase activity
H7K75_RS37020	COG3265	gluconokinase activity
H7K75_RS37030	COG3387	PFAM Glycoside hydrolase 15-related
H7K75_RS37035	COG1640	4-alpha-glucanotransferase
H7K75_RS37040	COG0366	Alpha amylase catalytic
H7K75_RS37045	COG0366	Alpha amylase catalytic
H7K75_RS37050	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H7K75_RS37060	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H7K75_RS37085	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H7K75_RS37090	COG0745	RESPONSE REGULATOR receiver
H7K75_RS37095	COG2205	protein histidine kinase activity
H7K75_RS37100	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H7K75_RS37105	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H7K75_RS37110	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H7K75_RS37140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7K75_RS37160	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H7K75_RS37165	COG0318	PFAM AMP-dependent synthetase and ligase
H7K75_RS37170	COG0427	acetyl-CoA hydrolase
H7K75_RS37200	COG2030	dehydratase
H7K75_RS37235	COG0477	Major facilitator Superfamily
H7K75_RS37250	COG1053	succinate dehydrogenase
H7K75_RS37255	COG1414	Transcriptional regulator
H7K75_RS37260	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS37265	COG0028	Belongs to the TPP enzyme family
H7K75_RS37265	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
H7K75_RS37285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K75_RS37290	COG0028	Belongs to the TPP enzyme family
H7K75_RS37295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7K75_RS37325	COG2272	Belongs to the type-B carboxylesterase lipase family
H7K75_RS37330	COG0477	Major facilitator Superfamily
H7K75_RS37335	COG1309	transcriptional regulator
H7K75_RS37340	COG4208	sulfate ABC transporter
H7K75_RS37345	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7K75_RS37355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K75_RS37365	COG3842	ATPase activity
H7K75_RS37370	COG0583	DNA-binding transcription factor activity
H7K75_RS37380	COG1063	alcohol dehydrogenase
H7K75_RS37385	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H7K75_RS37395	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H7K75_RS37405	COG0246	Mannitol dehydrogenase
H7K75_RS37430	COG0412	Dienelactone hydrolase
H7K75_RS37470	COG1684	flagellar biosynthetic protein fliR
H7K75_RS37475	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H7K75_RS37480	COG4794	Type iii secretion
H7K75_RS37485	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H7K75_RS37490	COG5443	negative regulation of bacterial-type flagellum assembly
H7K75_RS37510	COG1749	Flagellar hook protein flgE
H7K75_RS37530	COG1360	Flagellar Motor Protein
H7K75_RS37545	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7K75_RS37550	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7K75_RS37555	COG1338	Plays a role in the flagellum-specific transport system
H7K75_RS37565	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H7K75_RS37575	COG1706	bacterial-type flagellum-dependent cell motility
H7K75_RS37585	COG4786	Flagellar basal body rod
H7K75_RS37590	COG1677	Flagellar hook-basal body complex protein FliE
H7K75_RS37595	COG1558	bacterial-type flagellum-dependent cell motility
H7K75_RS37600	COG1815	bacterial-type flagellum-dependent cell motility
H7K75_RS37605	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H7K75_RS37610	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7K75_RS37615	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7K75_RS37630	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7K75_RS37640	COG4786	Flagellar basal body rod
H7K75_RS37645	COG1157	protein secretion by the type III secretion system
H7K75_RS37650	COG1846	Transcriptional regulator
H7K75_RS37695	COG0411	ABC transporter
H7K75_RS37700	COG0559	Belongs to the binding-protein-dependent transport system permease family
H7K75_RS37705	COG0683	leucine binding
H7K75_RS37720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7K75_RS37725	COG1464	Belongs to the NlpA lipoprotein family
H7K75_RS37730	COG0534	Mate efflux family protein
H7K75_RS37735	COG1309	transcriptional regulator
H7K75_RS37740	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7K75_RS37760	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
H7K75_RS37765	COG1126	abc transporter atp-binding protein
H7K75_RS37775	COG0765	amino acid transport
H7K75_RS37780	COG0765	amino acid transport
H7K75_RS37785	COG0673	inositol 2-dehydrogenase activity
H7K75_RS37805	COG1595	DNA-templated transcription, initiation
H7K75_RS37815	COG0477	Major facilitator Superfamily
H7K75_RS37835	COG4191	Histidine kinase
H7K75_RS37835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K75_RS37840	COG2204	response regulator
H7K75_RS37845	COG1024	Enoyl-CoA hydratase
H7K75_RS37845	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H7K75_RS37850	COG0309	Hydrogenase expression formation protein (HypE)
H7K75_RS37855	COG0409	Hydrogenase expression formation protein
H7K75_RS37900	COG1228	amidohydrolase
H7K75_RS37930	COG0583	DNA-binding transcription factor activity
H7K75_RS37935	COG0346	lactoylglutathione lyase activity
H7K75_RS37945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7K75_RS37975	COG2197	response regulator
H7K75_RS37990	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7K75_RS38005	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H7K75_RS38010	COG0459	protein refolding
H7K75_RS38020	COG0577	efflux transmembrane transporter activity
H7K75_RS38020	COG1136	(ABC) transporter
H7K75_RS38025	COG1136	(ABC) transporter
H7K75_RS38030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K75_RS38045	COG2072	flavoprotein involved in K transport
H7K75_RS38065	COG3920	Histidine kinase
H7K75_RS38100	COG0482	sulfurtransferase activity
H7K75_RS38110	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H7K75_RS38120	COG1766	The M ring may be actively involved in energy transduction
H7K75_RS38125	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7K75_RS38135	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7K75_RS38140	COG2204	response regulator
H7K75_RS38170	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7K75_RS38175	COG1116	anion transmembrane transporter activity
H7K75_RS38180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K75_RS38185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7K75_RS38190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7K75_RS38195	COG2124	cytochrome p450
H7K75_RS38220	COG0784	Response regulator, receiver
H7K75_RS38220	COG2205	protein histidine kinase activity
H7K75_RS38265	COG1309	transcriptional regulator
H7K75_RS38315	COG4689	acetoacetate decarboxylase
H7K75_RS38320	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS38340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7K75_RS38365	COG0243	molybdopterin cofactor binding
H7K75_RS38370	COG3043	anaerobic respiration
H7K75_RS38375	COG3005	denitrification pathway
H7K75_RS38380	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7K75_RS38390	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7K75_RS38395	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7K75_RS38440	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H7K75_RS38445	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H7K75_RS38495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7K75_RS38505	COG1175	transmembrane transport
H7K75_RS38510	COG0395	ABC-type sugar transport system, permease component
H7K75_RS38515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7K75_RS38520	COG0596	Alpha beta hydrolase
H7K75_RS38540	COG0848	biopolymer transport protein
H7K75_RS38560	COG4771	TonB-dependent receptor
H7K75_RS38575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7K75_RS38580	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H7K75_RS38590	COG4566	intracellular signal transduction
H7K75_RS38615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7K75_RS38625	COG2847	Copper chaperone PCu(A)C
H7K75_RS38660	COG1301	dicarboxylic acid transport
H7K75_RS38665	COG2828	Protein conserved in bacteria
H7K75_RS38680	COG1175	transmembrane transport
H7K75_RS38695	COG1177	transmembrane transport
H7K75_RS38700	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7K75_RS38705	COG3842	ATPase activity
H7K75_RS38715	COG5001	Diguanylate cyclase
H7K75_RS38715	COG3300	MHYT domain
H7K75_RS38745	COG3447	MASE1 domain protein
H7K75_RS38745	COG5001	Diguanylate cyclase
H7K75_RS38745	COG5002	protein histidine kinase activity
H7K75_RS38750	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H7K75_RS38755	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H7K75_RS38765	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7K75_RS38770	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H7K75_RS38790	COG0387	Pfam Sodium calcium exchanger
H7K75_RS38840	COG2204	response regulator
H7K75_RS38845	COG2989	Protein conserved in bacteria
H7K75_RS38860	COG3750	Belongs to the UPF0335 family
H7K75_RS38875	COG0469	pyruvate kinase activity
H7K75_RS38880	COG1309	transcriptional regulator
H7K75_RS38915	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7K75_RS38920	COG0037	tRNA processing
H7K75_RS38930	COG2885	chlorophyll binding
H7K75_RS38940	COG5001	Diguanylate cyclase
H7K75_RS38945	COG0823	Involved in the tonB-independent uptake of proteins
H7K75_RS38975	COG1045	serine acetyltransferase
H7K75_RS39020	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS39050	COG4941	Belongs to the sigma-70 factor family
H7K75_RS39055	COG3795	YCII-related domain
H7K75_RS39060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7K75_RS39075	COG0625	glutathione transferase activity
H7K75_RS39105	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H7K75_RS39130	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS39135	COG2233	PERMEase
H7K75_RS39140	COG1301	dicarboxylic acid transport
H7K75_RS39145	COG0488	(ABC) transporter
H7K75_RS39175	COG1177	transmembrane transport
H7K75_RS39180	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7K75_RS39185	COG3842	ATPase activity
H7K75_RS39200	COG0402	S-adenosylhomocysteine deaminase activity
H7K75_RS39220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K75_RS39230	COG0765	amino acid transport
H7K75_RS39250	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7K75_RS39250	COG0519	Catalyzes the synthesis of GMP from XMP
H7K75_RS39260	COG0824	Thioesterase
H7K75_RS39265	COG0824	Thioesterase
H7K75_RS39330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7K75_RS39360	COG1376	ErfK ybiS ycfS ynhG family protein
H7K75_RS39370	COG0028	Belongs to the TPP enzyme family
H7K75_RS39375	COG1388	LysM domain
H7K75_RS39375	COG1376	ErfK ybiS ycfS ynhG family protein
H7K75_RS39385	COG2226	methyltransferase
H7K75_RS39395	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7K75_RS39410	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H7K75_RS39415	COG0501	Belongs to the peptidase M48B family
H7K75_RS39435	COG0583	DNA-binding transcription factor activity
H7K75_RS39440	COG1960	acyl-CoA dehydrogenase activity
H7K75_RS39450	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
H7K75_RS39470	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS39475	COG1272	protein, Hemolysin III
H7K75_RS39480	COG3106	COG3106 Predicted ATPase
H7K75_RS39485	COG3768	UPF0283 membrane protein
H7K75_RS39510	COG1278	Cold shock
H7K75_RS39520	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H7K75_RS39520	COG0506	proline dehydrogenase activity
H7K75_RS39520	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H7K75_RS39545	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H7K75_RS39550	COG1704	LemA family
H7K75_RS39555	COG1024	Enoyl-CoA hydratase
H7K75_RS39560	COG1960	acyl-CoA dehydrogenase activity
H7K75_RS39565	COG1960	acyl-CoA dehydrogenase activity
H7K75_RS39575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7K75_RS39580	COG2514	catechol 2,3-dioxygenase activity
H7K75_RS39585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7K75_RS39595	COG0402	S-adenosylhomocysteine deaminase activity
H7K75_RS39600	COG2205	protein histidine kinase activity
H7K75_RS39645	COG0028	Belongs to the TPP enzyme family
H7K75_RS39650	COG0800	Aldolase
H7K75_RS39655	COG3734	2-keto-3-deoxy-galactonokinase
H7K75_RS39665	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7K75_RS39670	COG3284	Transcriptional regulator
H7K75_RS39675	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H7K75_RS39680	COG0318	PFAM AMP-dependent synthetase and ligase
H7K75_RS39705	COG1309	transcriptional regulator
H7K75_RS39735	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7K75_RS39745	COG2197	response regulator
H7K75_RS39755	COG4585	Histidine kinase
H7K75_RS39765	COG2235	arginine
H7K75_RS39780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K75_RS39805	COG1320	monovalent cation:proton antiporter activity
H7K75_RS39815	COG1006	Multisubunit Na H antiporter MnhC subunit
H7K75_RS39820	COG0651	ATP synthesis coupled electron transport
H7K75_RS39830	COG0670	Belongs to the BI1 family
H7K75_RS39850	COG0628	permease
H7K75_RS39895	COG1615	UPF0182 protein
H7K75_RS39915	COG0564	pseudouridine synthase activity
H7K75_RS39920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7K75_RS39935	COG3706	GGDEF domain
H7K75_RS39940	COG1280	lysine exporter protein (LysE YggA)
H7K75_RS39980	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7K75_RS39985	COG0358	DNA primase activity
H7K75_RS40015	COG1280	lysine exporter protein (LysE YggA)
H7K75_RS40030	COG0640	Transcriptional regulator
H7K75_RS40055	COG4191	Histidine kinase
H7K75_RS40055	COG0784	Response regulator, receiver
H7K75_RS40075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7K75_RS40080	COG0596	Alpha beta hydrolase
H7K75_RS40095	COG0505	Belongs to the CarA family
H7K75_RS40125	COG2814	Major facilitator Superfamily
H7K75_RS40130	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H7K75_RS40135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7K75_RS40140	COG1522	sequence-specific DNA binding
H7K75_RS40145	COG0492	ferredoxin-NADP+ reductase activity
H7K75_RS40150	COG0583	DNA-binding transcription factor activity
H7K75_RS40155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7K75_RS40190	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H7K75_RS40230	COG2205	protein histidine kinase activity
H7K75_RS40240	COG0183	Belongs to the thiolase family
H7K75_RS40245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7K75_RS40265	COG0625	glutathione transferase activity
H7K75_RS40280	COG2223	nitrite transmembrane transporter activity
H7K75_RS40285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7K75_RS40310	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7K75_RS40320	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H7K75_RS40330	COG0436	Aminotransferase
H7K75_RS40340	COG0625	glutathione transferase activity
H7K75_RS40365	COG0667	Aldo Keto reductase
H7K75_RS40400	COG0583	DNA-binding transcription factor activity
H7K75_RS40415	COG0556	nucleotide-excision repair
H7K75_RS40465	COG2030	dehydratase
H7K75_RS40475	COG0012	GTP binding
H7K75_RS40480	COG0193	aminoacyl-tRNA hydrolase activity
H7K75_RS40485	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H7K75_RS40500	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H7K75_RS40510	COG1496	oxidoreductase activity
H7K75_RS40520	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H7K75_RS40530	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7K75_RS40535	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H7K75_RS40545	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H7K75_RS40555	COG1942	4-Oxalocrotonate Tautomerase
H7K75_RS40560	COG0124	histidyl-tRNA synthetase
H7K75_RS40575	COG1846	Transcriptional regulator
H7K75_RS40580	COG0745	RESPONSE REGULATOR receiver
H7K75_RS40610	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H7K75_RS40615	COG1278	Cold shock
H7K75_RS40620	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H7K75_RS40625	COG0322	excinuclease ABC activity
H7K75_RS40630	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H7K75_RS40640	COG0314	molybdopterin synthase activity
H7K75_RS40645	COG2890	protein-(glutamine-N5) methyltransferase activity
H7K75_RS40655	COG1295	ribonuclease BN
H7K75_RS40660	COG2771	luxR family
H7K75_RS40660	COG2200	EAL domain
H7K75_RS40670	COG0745	RESPONSE REGULATOR receiver
H7K75_RS40675	COG0196	riboflavin kinase activity
H7K75_RS40680	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H7K75_RS40685	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H7K75_RS40695	COG0612	Peptidase, M16
H7K75_RS40700	COG0612	Peptidase, M16
H7K75_RS40740	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H7K75_RS40745	COG0742	ribosomal rna small subunit methyltransferase
H7K75_RS40750	COG1187	pseudouridine synthase activity
H7K75_RS40755	COG0590	tRNA wobble adenosine to inosine editing
H7K75_RS40760	COG0596	Alpha beta hydrolase
H7K75_RS40765	COG0151	Belongs to the GarS family
H7K75_RS40810	COG1570	exodeoxyribonuclease VII activity
H7K75_RS40845	COG1663	tetraacyldisaccharide 4'-kinase activity
H7K75_RS40850	COG1519	Transferase
H7K75_RS40870	COG0312	modulator of DNA gyrase
H7K75_RS40880	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H7K75_RS40895	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H7K75_RS40900	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H7K75_RS40905	COG0463	Glycosyl transferase, family 2
H7K75_RS40915	COG3416	Protein conserved in bacteria
H7K75_RS40920	COG1376	ErfK ybiS ycfS ynhG family protein
H7K75_RS40920	COG1388	LysM domain
H7K75_RS40935	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H7K75_RS40940	COG0459	protein refolding
H7K75_RS40955	COG1620	l-lactate permease
H7K75_RS40960	COG4178	(ABC) transporter
H7K75_RS40975	COG0247	lactate metabolic process
H7K75_RS40980	COG0277	FAD linked oxidase domain protein
H7K75_RS40990	COG0277	FAD linked oxidase domain protein
H7K75_RS40995	COG3474	cytochrome
H7K75_RS41020	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H7K75_RS41050	COG0583	DNA-binding transcription factor activity
H7K75_RS41080	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H7K75_RS41100	COG0583	DNA-binding transcription factor activity
H7K75_RS41110	COG1741	Belongs to the pirin family
H7K75_RS41115	COG0655	NAD(P)H dehydrogenase (quinone) activity
H7K75_RS41120	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7K75_RS41140	COG1215	transferase activity, transferring glycosyl groups
H7K75_RS41150	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7K75_RS41165	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7K75_RS41180	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H7K75_RS41190	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7K75_RS41225	COG0583	DNA-binding transcription factor activity
H7K75_RS41240	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7K75_RS41250	COG1126	abc transporter atp-binding protein
H7K75_RS41255	COG0765	amino acid transport
H7K75_RS41260	COG0765	amino acid transport
H7K75_RS41295	COG1902	pentaerythritol trinitrate reductase activity
H7K75_RS41300	COG1012	belongs to the aldehyde dehydrogenase family
H7K75_RS41315	COG2146	nitrite reductase [NAD(P)H] activity
H7K75_RS41350	COG4166	transmembrane transport
H7K75_RS41355	COG1472	Belongs to the glycosyl hydrolase 3 family
H7K75_RS41365	COG0745	RESPONSE REGULATOR receiver
H7K75_RS41370	COG2205	protein histidine kinase activity
H7K75_RS41415	COG0826	peptidase U32
H7K75_RS41425	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H7K75_RS41460	COG1082	Xylose isomerase domain protein TIM barrel
H7K75_RS41465	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H7K75_RS41495	COG4297	protein containing double-stranded beta helix domain
H7K75_RS41525	COG0438	transferase activity, transferring glycosyl groups
H7K75_RS41550	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H7K75_RS41555	COG3685	Protein conserved in bacteria
H7K75_RS41560	COG0723	plastoquinol--plastocyanin reductase activity
H7K75_RS41560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K75_RS41565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K75_RS41565	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H7K75_RS41595	COG0546	phosphoglycolate phosphatase activity
H7K75_RS41685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K75_RS41700	COG0604	alcohol dehydrogenase
H7K75_RS41765	COG2267	carboxylic ester hydrolase activity
H7K75_RS41880	COG1335	isochorismatase
H7K75_RS41925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K75_RS41950	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H7K75_RS41990	COG0583	DNA-binding transcription factor activity
H7K75_RS42005	COG1280	lysine exporter protein (LysE YggA)
H7K75_RS42015	COG2010	Cytochrome c
H7K75_RS42025	COG0071	Belongs to the small heat shock protein (HSP20) family
H7K75_RS42040	COG0067	glutamate synthase
H7K75_RS42040	COG0069	glutamate synthase activity
H7K75_RS42040	COG0070	glutamate synthase
H7K75_RS42085	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H7K75_RS42095	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
H7K75_RS42125	COG0251	oxidation-reduction process
H7K75_RS42135	COG4689	acetoacetate decarboxylase
H7K75_RS42160	COG0523	cobalamin synthesis protein
H7K75_RS42165	COG0803	Belongs to the bacterial solute-binding protein 9 family
H7K75_RS42175	COG1121	(ABC) transporter
H7K75_RS42195	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H7K75_RS42230	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS42245	COG0318	PFAM AMP-dependent synthetase and ligase
H7K75_RS42270	COG0326	Molecular chaperone. Has ATPase activity
H7K75_RS42300	COG0784	Response regulator, receiver
H7K75_RS42315	COG0778	Nitroreductase
H7K75_RS42320	COG1960	acyl-CoA dehydrogenase activity
H7K75_RS42325	COG1960	acyl-CoA dehydrogenase activity
H7K75_RS42330	COG1960	acyl-CoA dehydrogenase activity
H7K75_RS42335	COG0318	PFAM AMP-dependent synthetase and ligase
H7K75_RS42360	COG0318	PFAM AMP-dependent synthetase and ligase
H7K75_RS42370	COG2267	carboxylic ester hydrolase activity
H7K75_RS42385	COG1595	DNA-templated transcription, initiation
H7K75_RS42395	COG5285	phytanoyl-CoA dioxygenase
H7K75_RS42405	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H7K75_RS42415	COG1960	acyl-CoA dehydrogenase activity
H7K75_RS42420	COG0183	Belongs to the thiolase family
H7K75_RS42425	COG0318	PFAM AMP-dependent synthetase and ligase
H7K75_RS42450	COG0559	Belongs to the binding-protein-dependent transport system permease family
H7K75_RS42505	COG0583	DNA-binding transcription factor activity
H7K75_RS42530	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H7K75_RS42545	COG1024	Enoyl-CoA hydratase
H7K75_RS42550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7K75_RS42550	COG0318	PFAM AMP-dependent synthetase and ligase
H7K75_RS42550	COG0300	oxidoreductase activity
H7K75_RS42550	COG3321	synthase
H7K75_RS42550	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS42610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7K75_RS42615	COG1024	Enoyl-CoA hydratase
H7K75_RS42630	COG2378	regulation of single-species biofilm formation
H7K75_RS42645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7K75_RS42650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7K75_RS42655	COG0318	PFAM AMP-dependent synthetase and ligase
H7K75_RS42670	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7K75_RS42675	COG1879	ABC-type sugar transport system periplasmic component
H7K75_RS42690	COG1129	ABC transporter
H7K75_RS42695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K75_RS42700	COG0842	Transport permease protein
H7K75_RS42700	COG1129	ABC transporter
H7K75_RS42705	COG0842	Transport permease protein
H7K75_RS42735	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS42740	COG0640	Transcriptional regulator
H7K75_RS42785	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H7K75_RS42805	COG4245	von Willebrand factor, type A
H7K75_RS42820	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
H7K75_RS42835	COG4372	Transposase
H7K75_RS42855	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7K75_RS42875	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS42885	COG1028	Short-chain dehydrogenase reductase Sdr
H7K75_RS42900	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7K75_RS42915	COG2267	carboxylic ester hydrolase activity
H7K75_RS42925	COG0154	amidase activity
H7K75_RS42935	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H7K75_RS42940	COG1960	acyl-CoA dehydrogenase activity
H7K75_RS42945	COG4221	oxidoreductase activity
H7K75_RS42950	COG1024	Enoyl-CoA hydratase
H7K75_RS42965	COG0583	DNA-binding transcription factor activity
H7K75_RS42990	COG1058	Belongs to the CinA family
H7K75_RS42990	COG1546	Belongs to the CinA family
H7K75_RS43005	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H7K75_RS43010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K75_RS43015	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
H7K75_RS43025	COG0444	Belongs to the ABC transporter superfamily
H7K75_RS43030	COG0154	amidase activity
H7K75_RS43040	COG4608	Belongs to the ABC transporter superfamily
H7K75_RS43045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K75_RS43055	COG0747	negative chemotaxis
H7K75_RS43060	COG0747	negative chemotaxis
H7K75_RS43130	COG0588	phosphoglycerate mutase activity
H7K75_RS43150	COG2309	aminopeptidase activity
H7K75_RS43155	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H7K75_RS43180	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H7K75_RS43190	COG3454	Phosphonate metabolism
H7K75_RS43195	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
H7K75_RS43220	COG1024	Enoyl-CoA hydratase
H7K75_RS43230	COG1309	transcriptional regulator
H7K75_RS43250	COG0071	Belongs to the small heat shock protein (HSP20) family
H7K75_RS43255	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H7K75_RS43260	COG2610	gluconate transmembrane transporter activity
H7K75_RS43270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7K75_RS43285	COG4774	siderophore transport
H7K75_RS43290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7K75_RS43295	COG0277	FAD linked oxidase domain protein
H7K75_RS43300	COG1802	Transcriptional regulator
H7K75_RS43310	COG1032	radical SAM domain protein
H7K75_RS43315	COG1959	2 iron, 2 sulfur cluster binding
H7K75_RS43340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7K75_RS43355	COG2264	protein methyltransferase activity
H7K75_RS43390	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
H7K75_RS43420	COG2902	Dehydrogenase
H7K75_RS43450	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H7K75_RS43455	COG5001	Diguanylate cyclase
H7K75_RS43455	COG3300	MHYT domain
H7K75_RS43470	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H7K75_RS43475	COG0594	ribonuclease P activity
H7K75_RS43480	COG0706	membrane insertase activity
H7K75_RS43485	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H7K75_RS43495	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H7K75_RS43510	COG2171	N-acyltransferase activity
H7K75_RS43515	COG3152	Membrane
H7K75_RS43520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7K75_RS43525	COG0101	tRNA pseudouridine synthase activity
H7K75_RS43530	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H7K75_RS43535	COG0242	peptide deformylase activity
H7K75_RS43550	COG2223	nitrite transmembrane transporter activity
H7K75_RS43560	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H7K75_RS43565	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H7K75_RS43570	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H7K75_RS43580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K75_RS43585	COG0765	amino acid transport
H7K75_RS43615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7K75_RS43620	COG1522	sequence-specific DNA binding
H7K75_RS43625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7K75_RS43630	COG3577	Aspartyl protease
H7K75_RS43635	COG1643	Atp-dependent helicase
H7K75_RS43640	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H7K75_RS43650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7K75_RS43650	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7K75_RS43655	COG1280	lysine exporter protein (LysE YggA)
H7K75_RS43660	COG0625	glutathione transferase activity
H7K75_RS43665	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H7K75_RS43675	COG3415	Transposase
H7K75_RS43675	COG2801	Transposase and inactivated derivatives
H7K75_RS43685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7K75_RS43695	COG0058	SHG alpha-glucan phosphorylase activity
H7K75_RS43705	COG2801	Transposase and inactivated derivatives
H7K75_RS43705	COG3415	Transposase
H7K75_RS43725	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H7K75_RS43740	COG0745	RESPONSE REGULATOR receiver
H7K75_RS43745	COG2205	protein histidine kinase activity
H7K75_RS43755	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7K75_RS43755	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7K75_RS43770	COG0481	GTPase activity
H7K75_RS43790	COG1794	racemase activity, acting on amino acids and derivatives
H7K75_RS43800	COG1960	acyl-CoA dehydrogenase activity
H7K75_RS43805	COG5001	Diguanylate cyclase
H7K75_RS43815	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
H7K75_RS43825	COG0725	ABC transporter, periplasmic molybdate-binding protein
H7K75_RS43830	COG4149	molybdate abc transporter
H7K75_RS43835	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H7K75_RS43840	COG0438	transferase activity, transferring glycosyl groups
H7K75_RS43850	COG0586	Pfam SNARE associated Golgi protein
H7K75_RS43860	COG3263	regulation of cellular component size
H7K75_RS43865	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H7K75_RS43865	COG3264	Mechanosensitive ion channel
H7K75_RS43870	COG0024	Methionine aminopeptidase
H7K75_RS43885	COG2003	Belongs to the UPF0758 family
H7K75_RS43890	COG0582	viral genome integration into host DNA
H7K75_RS43895	COG4804	nuclease activity
H7K75_RS43905	COG0419	ATPase involved in DNA repair
H7K75_RS43935	COG3293	Transposase
H7K75_RS43950	COG1309	transcriptional regulator
H7K75_RS43955	COG1376	ErfK ybiS ycfS ynhG family protein
H7K75_RS43960	COG0300	oxidoreductase activity
H7K75_RS44045	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H7K75_RS44115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7K75_RS44135	COG4584	PFAM Integrase catalytic
H7K75_RS44175	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7K75_RS44185	COG0405	Gamma-glutamyltransferase
H7K75_RS44215	COG3436	PFAM IS66 Orf2 family protein
H7K75_RS44235	COG3831	ATPase activity
H7K75_RS44290	COG1278	Cold shock
H7K75_RS44400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7K75_RS44410	COG0583	DNA-binding transcription factor activity
H7K75_RS44430	COG0596	Alpha beta hydrolase
H7K75_RS44440	COG2948	multi-organism process
H7K75_RS44450	COG3701	Conjugal transfer protein
H7K75_RS44470	COG3451	type IV secretory pathway VirB4
H7K75_RS44480	COG3838	Conjugal transfer protein Trbc
H7K75_RS44485	COG4962	Type ii secretion system protein e
H7K75_RS44510	COG5265	(ABC) transporter
H7K75_RS44535	COG3547	Transposase (IS116 IS110 IS902 family)
H7K75_RS44565	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7K75_RS44575	COG0776	regulation of translation
H7K75_RS44585	COG3344	reverse transcriptase
H7K75_RS44590	COG2801	Transposase and inactivated derivatives