locus-tag	class	description
H7K74_RS00020	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7K74_RS00020	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H7K74_RS00045	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7K74_RS00080	COG2010	Cytochrome c
H7K74_RS00105	COG4716	Myosin-crossreactive antigen
H7K74_RS00145	COG2963	transposase activity
H7K74_RS00150	COG3436	PFAM IS66 Orf2 family protein
H7K74_RS00155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K74_RS00160	COG0765	amino acid transport
H7K74_RS00165	COG1396	sequence-specific DNA binding
H7K74_RS00220	COG1192	Involved in chromosome partitioning
H7K74_RS00260	COG5489	Protein of unknown function (DUF736)
H7K74_RS00270	COG1278	Cold shock
H7K74_RS00275	COG2226	methyltransferase
H7K74_RS00320	COG2925	Exonuclease
H7K74_RS00370	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H7K74_RS00375	COG2003	Belongs to the UPF0758 family
H7K74_RS00410	COG4941	Belongs to the sigma-70 factor family
H7K74_RS00425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7K74_RS00430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K74_RS00460	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H7K74_RS00470	COG1253	flavin adenine dinucleotide binding
H7K74_RS00480	COG0069	glutamate synthase activity
H7K74_RS00495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K74_RS00500	COG1301	dicarboxylic acid transport
H7K74_RS00505	COG2130	NADP-dependent
H7K74_RS00560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7K74_RS00565	COG0583	DNA-binding transcription factor activity
H7K74_RS00575	COG1024	Enoyl-CoA hydratase
H7K74_RS00590	COG1960	acyl-CoA dehydrogenase activity
H7K74_RS00610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7K74_RS00615	COG3964	amidohydrolase
H7K74_RS00645	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7K74_RS00670	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H7K74_RS00680	COG2261	transglycosylase associated protein
H7K74_RS00695	COG1960	acyl-CoA dehydrogenase activity
H7K74_RS00715	COG1024	Enoyl-CoA hydratase
H7K74_RS00735	COG0477	Major facilitator Superfamily
H7K74_RS00740	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H7K74_RS00745	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7K74_RS00755	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H7K74_RS00770	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H7K74_RS00800	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H7K74_RS00805	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H7K74_RS00820	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H7K74_RS00840	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H7K74_RS00885	COG1902	pentaerythritol trinitrate reductase activity
H7K74_RS00915	COG0586	Pfam SNARE associated Golgi protein
H7K74_RS00920	COG0372	Belongs to the citrate synthase family
H7K74_RS00925	COG0372	Belongs to the citrate synthase family
H7K74_RS00940	COG4536	flavin adenine dinucleotide binding
H7K74_RS00945	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H7K74_RS00950	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H7K74_RS00960	COG4974	Belongs to the 'phage' integrase family
H7K74_RS00965	COG0825	malonyl-CoA metabolic process
H7K74_RS00970	COG3034	peptidoglycan biosynthetic process
H7K74_RS00980	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H7K74_RS01010	COG1846	Transcriptional regulator
H7K74_RS01030	COG0653	protein targeting
H7K74_RS01035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7K74_RS01040	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H7K74_RS01055	COG1040	competence protein
H7K74_RS01060	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H7K74_RS01065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7K74_RS01080	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7K74_RS01090	COG0527	aspartate kinase activity
H7K74_RS01095	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
H7K74_RS01100	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H7K74_RS01105	COG2890	protein-(glutamine-N5) methyltransferase activity
H7K74_RS01120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7K74_RS01130	COG0697	spore germination
H7K74_RS01145	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
H7K74_RS01160	COG0657	acetylesterase activity
H7K74_RS01195	COG0583	DNA-binding transcription factor activity
H7K74_RS01200	COG2072	flavoprotein involved in K transport
H7K74_RS01210	COG1522	sequence-specific DNA binding
H7K74_RS01215	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H7K74_RS01220	COG0514	ATP-dependent DNA helicase (RecQ)
H7K74_RS01235	COG2873	o-acetylhomoserine
H7K74_RS01240	COG0154	amidase activity
H7K74_RS01250	COG1228	amidohydrolase
H7K74_RS01255	COG0667	Aldo Keto reductase
H7K74_RS01260	COG2814	Major facilitator Superfamily
H7K74_RS01265	COG0583	DNA-binding transcription factor activity
H7K74_RS01270	COG3257	ureidoglycine aminohydrolase activity
H7K74_RS01290	COG4191	Histidine kinase
H7K74_RS01295	COG4566	intracellular signal transduction
H7K74_RS01305	COG1289	transmembrane transporter activity
H7K74_RS01315	COG1566	PFAM secretion protein HlyD family protein
H7K74_RS01320	COG2169	Transcriptional regulator
H7K74_RS01335	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
H7K74_RS01355	COG3052	prosthetic group binding
H7K74_RS01390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K74_RS01400	COG4191	Histidine kinase
H7K74_RS01405	COG0243	molybdopterin cofactor binding
H7K74_RS01410	COG2140	Oxalate decarboxylase
H7K74_RS01415	COG1294	oxidase, subunit
H7K74_RS01420	COG1271	oxidase subunit
H7K74_RS01425	COG0579	oxidoreductase
H7K74_RS01435	COG0114	fumarate hydratase activity
H7K74_RS01445	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H7K74_RS01470	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS01515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K74_RS01520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K74_RS01525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7K74_RS01565	COG0601	transmembrane transport
H7K74_RS01575	COG0444	Belongs to the ABC transporter superfamily
H7K74_RS01580	COG4608	Belongs to the ABC transporter superfamily
H7K74_RS01595	COG4263	nitrous-oxide reductase activity
H7K74_RS01635	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H7K74_RS01640	COG1877	trehalose-phosphatase activity
H7K74_RS01645	COG0477	Major facilitator Superfamily
H7K74_RS01670	COG2198	Histidine kinase
H7K74_RS01670	COG5002	protein histidine kinase activity
H7K74_RS01670	COG0784	Response regulator, receiver
H7K74_RS01715	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7K74_RS01725	COG1522	sequence-specific DNA binding
H7K74_RS01730	COG3813	Protein conserved in bacteria
H7K74_RS01740	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H7K74_RS01755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7K74_RS01760	COG1846	Transcriptional regulator
H7K74_RS01805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7K74_RS01840	COG5001	Diguanylate cyclase
H7K74_RS01845	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H7K74_RS01865	COG2706	6-phosphogluconolactonase activity
H7K74_RS01895	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H7K74_RS01905	COG1696	Membrane protein involved in D-alanine export
H7K74_RS01915	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7K74_RS01950	COG4566	intracellular signal transduction
H7K74_RS01955	COG0784	Response regulator, receiver
H7K74_RS01955	COG4191	Histidine kinase
H7K74_RS01960	COG4566	intracellular signal transduction
H7K74_RS01970	COG2201	protein-glutamate methylesterase activity
H7K74_RS01990	COG0835	chemotaxis
H7K74_RS01995	COG0643	Histidine kinase
H7K74_RS01995	COG0784	Response regulator, receiver
H7K74_RS01995	COG2198	Histidine kinase
H7K74_RS02000	COG3437	response regulator, receiver
H7K74_RS02050	COG0697	spore germination
H7K74_RS02055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7K74_RS02075	COG3181	Tripartite tricarboxylate transporter family receptor
H7K74_RS02085	COG0583	DNA-binding transcription factor activity
H7K74_RS02090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K74_RS02100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7K74_RS02105	COG0473	3-isopropylmalate dehydrogenase activity
H7K74_RS02110	COG0066	3-isopropylmalate dehydratase activity
H7K74_RS02115	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H7K74_RS02120	COG0583	DNA-binding transcription factor activity
H7K74_RS02140	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H7K74_RS02145	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H7K74_RS02165	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H7K74_RS02180	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H7K74_RS02185	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H7K74_RS02190	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H7K74_RS02195	COG0799	negative regulation of ribosome biogenesis
H7K74_RS02200	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H7K74_RS02210	COG0793	Belongs to the peptidase S41A family
H7K74_RS02220	COG1051	belongs to the nudix hydrolase family
H7K74_RS02225	COG0494	nUDIX hydrolase
H7K74_RS02235	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H7K74_RS02240	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H7K74_RS02245	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H7K74_RS02250	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H7K74_RS02255	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H7K74_RS02260	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H7K74_RS02270	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H7K74_RS02285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7K74_RS02290	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS02295	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7K74_RS02305	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H7K74_RS02315	COG0045	succinate-CoA ligase (ADP-forming) activity
H7K74_RS02320	COG0039	L-malate dehydrogenase activity
H7K74_RS02325	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H7K74_RS02330	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H7K74_RS02340	COG1136	(ABC) transporter
H7K74_RS02345	COG0577	efflux transmembrane transporter activity
H7K74_RS02345	COG1136	(ABC) transporter
H7K74_RS02350	COG0670	Belongs to the BI1 family
H7K74_RS02370	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H7K74_RS02375	COG4133	protoheme IX ABC transporter activity
H7K74_RS02380	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7K74_RS02385	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7K74_RS02395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7K74_RS02400	COG2917	probably involved in intracellular septation
H7K74_RS02405	COG0552	protein localization to endoplasmic reticulum
H7K74_RS02410	COG0564	pseudouridine synthase activity
H7K74_RS02420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7K74_RS02425	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H7K74_RS02445	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H7K74_RS02450	COG0228	four-way junction DNA binding
H7K74_RS02455	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H7K74_RS02470	COG0336	Belongs to the RNA methyltransferase TrmD family
H7K74_RS02475	COG0335	large ribosomal subunit rRNA binding
H7K74_RS02480	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H7K74_RS02520	COG0066	3-isopropylmalate dehydratase activity
H7K74_RS02540	COG2301	Belongs to the HpcH HpaI aldolase family
H7K74_RS02545	COG0288	reversible hydration of carbon dioxide
H7K74_RS02550	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H7K74_RS02565	COG0473	3-isopropylmalate dehydrogenase activity
H7K74_RS02575	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H7K74_RS02580	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
H7K74_RS02585	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H7K74_RS02590	COG4221	oxidoreductase activity
H7K74_RS02595	COG0318	PFAM AMP-dependent synthetase and ligase
H7K74_RS02600	COG0730	response to heat
H7K74_RS02605	COG0583	DNA-binding transcription factor activity
H7K74_RS02630	COG0784	Response regulator, receiver
H7K74_RS02630	COG4191	Histidine kinase
H7K74_RS02635	COG4178	(ABC) transporter
H7K74_RS02655	COG0137	argininosuccinate synthase activity
H7K74_RS02660	COG0671	phosphoesterase, PA-phosphatase related
H7K74_RS02670	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H7K74_RS02680	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS02685	COG3321	synthase
H7K74_RS02685	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS02685	COG0604	alcohol dehydrogenase
H7K74_RS02705	COG2154	pterin-4-alpha-carbinolamine dehydratase
H7K74_RS02720	COG0784	Response regulator, receiver
H7K74_RS02750	COG1217	gtp-binding protein TYPA
H7K74_RS02765	COG3011	Protein conserved in bacteria
H7K74_RS02785	COG1247	-acetyltransferase
H7K74_RS02790	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H7K74_RS02795	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H7K74_RS02815	COG1024	Enoyl-CoA hydratase
H7K74_RS02825	COG4221	oxidoreductase activity
H7K74_RS02850	COG2814	Major facilitator Superfamily
H7K74_RS02895	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H7K74_RS02900	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H7K74_RS02910	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H7K74_RS02925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7K74_RS02930	COG1376	ErfK ybiS ycfS ynhG family protein
H7K74_RS02940	COG0840	transmembrane signaling receptor activity
H7K74_RS02945	COG4529	Protein conserved in bacteria
H7K74_RS02965	COG0138	bifunctional purine biosynthesis protein purh
H7K74_RS02975	COG0405	Gamma-glutamyltransferase
H7K74_RS02980	COG2814	Major facilitator Superfamily
H7K74_RS02995	COG0534	Mate efflux family protein
H7K74_RS03005	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H7K74_RS03020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7K74_RS03030	COG3118	belongs to the thioredoxin family
H7K74_RS03040	COG5001	Diguanylate cyclase
H7K74_RS03040	COG3300	MHYT domain
H7K74_RS03070	COG2835	tetraacyldisaccharide 4'-kinase activity
H7K74_RS03075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7K74_RS03080	COG1946	Acyl-CoA thioesterase
H7K74_RS03090	COG0347	Belongs to the P(II) protein family
H7K74_RS03095	COG0004	ammonium transporteR
H7K74_RS03100	COG0640	Transcriptional regulator
H7K74_RS03110	COG0740	serine-type endopeptidase activity
H7K74_RS03115	COG0347	Belongs to the P(II) protein family
H7K74_RS03120	COG0004	ammonium transporteR
H7K74_RS03130	COG0436	Aminotransferase
H7K74_RS03135	COG1674	ftsk spoiiie
H7K74_RS03140	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H7K74_RS03155	COG0745	RESPONSE REGULATOR receiver
H7K74_RS03175	COG2203	Gaf domain
H7K74_RS03175	COG5001	Diguanylate cyclase
H7K74_RS03175	COG4251	negative regulation of phosphorylation
H7K74_RS03175	COG3706	GGDEF domain
H7K74_RS03190	COG0495	leucyl-tRNA aminoacylation
H7K74_RS03215	COG0357	Ribosomal RNA small subunit methyltransferase G
H7K74_RS03220	COG0445	tRNA wobble uridine modification
H7K74_RS03225	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H7K74_RS03230	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H7K74_RS03235	COG1981	membrane
H7K74_RS03240	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H7K74_RS03245	COG0424	maF-like protein
H7K74_RS03250	COG0237	dephospho-CoA kinase activity
H7K74_RS03255	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7K74_RS03260	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H7K74_RS03270	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H7K74_RS03285	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H7K74_RS03300	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H7K74_RS03305	COG0131	Imidazoleglycerol-phosphate dehydratase
H7K74_RS03315	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H7K74_RS03320	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H7K74_RS03325	COG0107	imidazoleglycerol-phosphate synthase activity
H7K74_RS03330	COG0140	phosphoribosyl-ATP diphosphatase activity
H7K74_RS03335	COG1072	(Pantothenic acid kinase))
H7K74_RS03350	COG0784	Response regulator, receiver
H7K74_RS03350	COG5002	protein histidine kinase activity
H7K74_RS03350	COG2205	protein histidine kinase activity
H7K74_RS03385	COG4964	Belongs to the GSP D family
H7K74_RS03395	COG0189	ligase activity
H7K74_RS03400	COG0792	nuclease activity
H7K74_RS03405	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H7K74_RS03415	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7K74_RS03420	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H7K74_RS03425	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H7K74_RS03430	COG1420	regulation of RNA biosynthetic process
H7K74_RS03435	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H7K74_RS03440	COG1335	isochorismatase
H7K74_RS03450	COG0443	Heat shock 70 kDa protein
H7K74_RS03455	COG0484	heat shock protein binding
H7K74_RS03460	COG3963	phosphatidate phosphatase activity
H7K74_RS03465	COG0431	NADPH-dependent FMN reductase
H7K74_RS03470	COG0284	orotidine-5'-phosphate decarboxylase activity
H7K74_RS03480	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H7K74_RS03485	COG0588	phosphoglycerate mutase activity
H7K74_RS03490	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H7K74_RS03500	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H7K74_RS03530	COG2814	Major facilitator Superfamily
H7K74_RS03540	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7K74_RS03545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7K74_RS03550	COG0864	Transcriptional regulator
H7K74_RS03560	COG1937	Protein conserved in bacteria
H7K74_RS03580	COG0072	phenylalanine-tRNA ligase activity
H7K74_RS03580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7K74_RS03585	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H7K74_RS03595	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H7K74_RS03600	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H7K74_RS03610	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H7K74_RS03630	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H7K74_RS03640	COG1968	undecaprenyl-diphosphatase activity
H7K74_RS03665	COG1401	restriction endodeoxyribonuclease activity
H7K74_RS03700	COG0515	serine threonine protein kinase
H7K74_RS03700	COG2815	serine threonine protein kinase
H7K74_RS03805	COG3591	Belongs to the peptidase S1B family
H7K74_RS03830	COG2814	Major facilitator Superfamily
H7K74_RS03845	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H7K74_RS03850	COG1137	ATPase activity
H7K74_RS03855	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H7K74_RS03860	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H7K74_RS03865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7K74_RS03885	COG0071	Belongs to the small heat shock protein (HSP20) family
H7K74_RS03890	COG3842	ATPase activity
H7K74_RS03895	COG0395	ABC-type sugar transport system, permease component
H7K74_RS03915	COG1764	response to oxidative stress
H7K74_RS03920	COG1846	Transcriptional regulator
H7K74_RS03935	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H7K74_RS03940	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H7K74_RS03945	COG0539	negative regulation of cytoplasmic translation
H7K74_RS03950	COG0616	signal peptide processing
H7K74_RS03955	COG0776	regulation of translation
H7K74_RS03965	COG0135	phosphoribosylanthranilate isomerase activity
H7K74_RS03970	COG0133	tryptophan synthase activity
H7K74_RS03975	COG0159	tryptophan synthase activity
H7K74_RS03980	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H7K74_RS03985	COG0285	dihydrofolate synthase activity
H7K74_RS04005	COG1074	ATP-dependent DNA helicase activity
H7K74_RS04015	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H7K74_RS04025	COG3178	'Phosphotransferase
H7K74_RS04030	COG2205	protein histidine kinase activity
H7K74_RS04035	COG0756	dUTP diphosphatase activity
H7K74_RS04040	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H7K74_RS04045	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H7K74_RS04050	COG2226	methyltransferase
H7K74_RS04055	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H7K74_RS04070	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7K74_RS04090	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7K74_RS04100	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7K74_RS04110	COG0625	glutathione transferase activity
H7K74_RS04135	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H7K74_RS04140	COG1185	polyribonucleotide nucleotidyltransferase activity
H7K74_RS04145	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H7K74_RS04150	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H7K74_RS04155	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H7K74_RS04160	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H7K74_RS04175	COG0779	Required for maturation of 30S ribosomal subunits
H7K74_RS04185	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H7K74_RS04195	COG1396	sequence-specific DNA binding
H7K74_RS04200	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H7K74_RS04205	COG1253	flavin adenine dinucleotide binding
H7K74_RS04210	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H7K74_RS04215	COG1702	phosphate starvation-inducible protein PhoH
H7K74_RS04220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7K74_RS04225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7K74_RS04255	COG0180	Tryptophanyl-tRNA synthetase
H7K74_RS04265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7K74_RS04295	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H7K74_RS04300	COG1741	Belongs to the pirin family
H7K74_RS04340	COG0534	Mate efflux family protein
H7K74_RS04345	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H7K74_RS04370	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H7K74_RS04375	COG2852	Protein conserved in bacteria
H7K74_RS04385	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H7K74_RS04390	COG0268	Binds directly to 16S ribosomal RNA
H7K74_RS04400	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7K74_RS04415	COG0412	Dienelactone hydrolase
H7K74_RS04485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7K74_RS04500	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H7K74_RS04505	COG1032	radical SAM domain protein
H7K74_RS04560	COG0582	viral genome integration into host DNA
H7K74_RS04690	COG5001	Diguanylate cyclase
H7K74_RS04710	COG0411	ABC transporter
H7K74_RS04730	COG3290	protein histidine kinase activity
H7K74_RS04730	COG3829	transcription factor binding
H7K74_RS04735	COG5001	Diguanylate cyclase
H7K74_RS04745	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS04765	COG0477	Major facilitator Superfamily
H7K74_RS04775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7K74_RS04780	COG0366	Alpha amylase catalytic
H7K74_RS04795	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H7K74_RS04805	COG1131	(ABC) transporter
H7K74_RS04825	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H7K74_RS04855	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H7K74_RS04865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K74_RS04890	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H7K74_RS04895	COG0183	Belongs to the thiolase family
H7K74_RS04900	COG3485	protocatechuate 3,4-dioxygenase
H7K74_RS04905	COG3485	protocatechuate 3,4-dioxygenase
H7K74_RS04910	COG3485	protocatechuate 3,4-dioxygenase
H7K74_RS04915	COG0840	transmembrane signaling receptor activity
H7K74_RS04925	COG2814	Major facilitator Superfamily
H7K74_RS04930	COG1566	PFAM secretion protein HlyD family protein
H7K74_RS04940	COG0735	belongs to the Fur family
H7K74_RS04950	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H7K74_RS04955	COG2175	clavaminate synthase activity
H7K74_RS04970	COG0025	NhaP-type Na H and K H
H7K74_RS05000	COG0142	geranyltranstransferase activity
H7K74_RS05005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7K74_RS05010	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H7K74_RS05025	COG5001	Diguanylate cyclase
H7K74_RS05025	COG3300	MHYT domain
H7K74_RS05045	COG5001	Diguanylate cyclase
H7K74_RS05055	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H7K74_RS05065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7K74_RS05070	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H7K74_RS05075	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H7K74_RS05090	COG2072	flavoprotein involved in K transport
H7K74_RS05095	COG0745	RESPONSE REGULATOR receiver
H7K74_RS05100	COG2198	Histidine kinase
H7K74_RS05100	COG5002	protein histidine kinase activity
H7K74_RS05100	COG0784	Response regulator, receiver
H7K74_RS05120	COG1129	ABC transporter
H7K74_RS05140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7K74_RS05180	COG1960	acyl-CoA dehydrogenase activity
H7K74_RS05185	COG1960	acyl-CoA dehydrogenase activity
H7K74_RS05200	COG3246	L-lysine catabolic process to acetate
H7K74_RS05205	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7K74_RS05220	COG4608	Belongs to the ABC transporter superfamily
H7K74_RS05225	COG0444	Belongs to the ABC transporter superfamily
H7K74_RS05230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K74_RS05235	COG0601	transmembrane transport
H7K74_RS05255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K74_RS05265	COG0683	leucine binding
H7K74_RS05270	COG3788	relative of glutathione S-transferase, MAPEG superfamily
H7K74_RS05300	COG2271	Major facilitator Superfamily
H7K74_RS05320	COG0737	Belongs to the 5'-nucleotidase family
H7K74_RS05330	COG3258	Cytochrome c
H7K74_RS05345	COG4654	Cytochrome c, class I
H7K74_RS05355	COG1505	serine-type exopeptidase activity
H7K74_RS05360	COG2814	Major facilitator Superfamily
H7K74_RS05370	COG2514	catechol 2,3-dioxygenase activity
H7K74_RS05380	COG1960	acyl-CoA dehydrogenase activity
H7K74_RS05385	COG1960	acyl-CoA dehydrogenase activity
H7K74_RS05390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K74_RS05415	COG1595	DNA-templated transcription, initiation
H7K74_RS05425	COG0784	Response regulator, receiver
H7K74_RS05425	COG3437	response regulator, receiver
H7K74_RS05430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K74_RS05430	COG4191	Histidine kinase
H7K74_RS05435	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H7K74_RS05460	COG0747	negative chemotaxis
H7K74_RS05465	COG0601	transmembrane transport
H7K74_RS05470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K74_RS05475	COG4172	Belongs to the ABC transporter superfamily
H7K74_RS05495	COG1802	Transcriptional regulator
H7K74_RS05510	COG0318	PFAM AMP-dependent synthetase and ligase
H7K74_RS05520	COG2124	cytochrome p450
H7K74_RS05535	COG1252	NADH dehydrogenase
H7K74_RS05560	COG4177	L-phenylalanine transmembrane transporter activity
H7K74_RS05575	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7K74_RS05580	COG0583	DNA-binding transcription factor activity
H7K74_RS05590	COG2197	response regulator
H7K74_RS05595	COG3916	Acyl-homoserine-lactone synthase
H7K74_RS05635	COG4638	Rieske (2fe-2S)
H7K74_RS05640	COG1414	Transcriptional regulator
H7K74_RS05665	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H7K74_RS05670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7K74_RS05705	COG3047	cAMP biosynthetic process
H7K74_RS05705	COG2885	chlorophyll binding
H7K74_RS05720	COG0596	Alpha beta hydrolase
H7K74_RS05740	COG5002	protein histidine kinase activity
H7K74_RS05745	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H7K74_RS05750	COG0573	inorganic phosphate transmembrane transporter activity
H7K74_RS05755	COG0581	inorganic phosphate transmembrane transporter activity
H7K74_RS05760	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H7K74_RS05765	COG0704	Plays a role in the regulation of phosphate uptake
H7K74_RS05770	COG0745	RESPONSE REGULATOR receiver
H7K74_RS05780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7K74_RS05785	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H7K74_RS05800	COG2967	ApaG domain
H7K74_RS05825	COG0717	Belongs to the dCTP deaminase family
H7K74_RS05870	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H7K74_RS05995	COG2267	carboxylic ester hydrolase activity
H7K74_RS06000	COG1396	sequence-specific DNA binding
H7K74_RS06020	COG1070	Carbohydrate kinase
H7K74_RS06025	COG2115	Belongs to the xylose isomerase family
H7K74_RS06030	COG1129	ABC transporter
H7K74_RS06035	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7K74_RS06065	COG0251	oxidation-reduction process
H7K74_RS06090	COG1999	signal sequence binding
H7K74_RS06100	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
H7K74_RS06135	COG0167	dihydroorotate dehydrogenase activity
H7K74_RS06145	COG1234	tRNA 3'-trailer cleavage
H7K74_RS06175	COG1201	RNA secondary structure unwinding
H7K74_RS06185	COG0583	DNA-binding transcription factor activity
H7K74_RS06190	COG0697	spore germination
H7K74_RS06205	COG0730	response to heat
H7K74_RS06215	COG1695	Transcriptional regulator
H7K74_RS06225	COG1960	acyl-CoA dehydrogenase activity
H7K74_RS06230	COG0183	Belongs to the thiolase family
H7K74_RS06235	COG1024	Enoyl-CoA hydratase
H7K74_RS06235	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7K74_RS06240	COG3344	reverse transcriptase
H7K74_RS06250	COG0625	glutathione transferase activity
H7K74_RS06275	COG0681	Belongs to the peptidase S26 family
H7K74_RS06280	COG0312	modulator of DNA gyrase
H7K74_RS06290	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H7K74_RS06295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7K74_RS06300	COG0109	protoheme IX farnesyltransferase activity
H7K74_RS06310	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H7K74_RS06325	COG3346	SURF1 family
H7K74_RS06350	COG0612	Peptidase, M16
H7K74_RS06355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7K74_RS06365	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H7K74_RS06370	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H7K74_RS06380	COG0356	it plays a direct role in the translocation of protons across the membrane
H7K74_RS06400	COG0432	Pfam Uncharacterised protein family UPF0047
H7K74_RS06420	COG1764	response to oxidative stress
H7K74_RS06425	COG0596	Alpha beta hydrolase
H7K74_RS06435	COG2205	protein histidine kinase activity
H7K74_RS06435	COG0784	Response regulator, receiver
H7K74_RS06440	COG0156	8-amino-7-oxononanoate synthase activity
H7K74_RS06445	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H7K74_RS06495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K74_RS06540	COG2020	methyltransferase activity
H7K74_RS06550	COG2188	Transcriptional regulator
H7K74_RS06555	COG3624	Phosphonate C-P lyase system protein PhnG
H7K74_RS06560	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
H7K74_RS06565	COG3626	phosphonate metabolism
H7K74_RS06570	COG3627	carbon phosphorus lyase activity
H7K74_RS06575	COG4107	phosphonate C-P lyase system protein PhnK
H7K74_RS06580	COG4778	phosphonate C-P lyase system protein PhnL
H7K74_RS06585	COG3454	Phosphonate metabolism
H7K74_RS06590	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
H7K74_RS06610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7K74_RS06615	COG2267	carboxylic ester hydrolase activity
H7K74_RS06630	COG3181	Tripartite tricarboxylate transporter family receptor
H7K74_RS06635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7K74_RS06640	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7K74_RS06645	COG3971	2-oxopent-4-enoate hydratase activity
H7K74_RS06660	COG2197	response regulator
H7K74_RS06685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7K74_RS06690	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H7K74_RS06770	COG0492	ferredoxin-NADP+ reductase activity
H7K74_RS06800	COG0702	epimerase
H7K74_RS06810	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H7K74_RS06815	COG5328	Belongs to the UPF0262 family
H7K74_RS06820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H7K74_RS06825	COG0424	maF-like protein
H7K74_RS06830	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H7K74_RS06840	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H7K74_RS06845	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
H7K74_RS06865	COG3052	prosthetic group binding
H7K74_RS06885	COG2186	Transcriptional regulator
H7K74_RS06895	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H7K74_RS06925	COG1335	isochorismatase
H7K74_RS06935	COG1022	Amp-dependent synthetase and ligase
H7K74_RS06940	COG4716	Myosin-crossreactive antigen
H7K74_RS06945	COG4191	Histidine kinase
H7K74_RS06970	COG0667	Aldo Keto reductase
H7K74_RS07015	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS07050	COG3047	cAMP biosynthetic process
H7K74_RS07065	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H7K74_RS07070	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H7K74_RS07075	COG0328	RNA-DNA hybrid ribonuclease activity
H7K74_RS07080	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H7K74_RS07080	COG0678	peroxiredoxin activity
H7K74_RS07090	COG0318	PFAM AMP-dependent synthetase and ligase
H7K74_RS07095	COG1686	Belongs to the peptidase S11 family
H7K74_RS07100	COG1132	(ABC) transporter
H7K74_RS07120	COG0140	phosphoribosyl-ATP diphosphatase activity
H7K74_RS07125	COG1238	metal cluster binding
H7K74_RS07135	COG1027	Aspartate ammonia-lyase
H7K74_RS07150	COG0318	PFAM AMP-dependent synthetase and ligase
H7K74_RS07155	COG2070	2-Nitropropane dioxygenase
H7K74_RS07190	COG4585	Histidine kinase
H7K74_RS07220	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H7K74_RS07265	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7K74_RS07265	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7K74_RS07280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7K74_RS07285	COG1473	amidohydrolase
H7K74_RS07295	COG0601	transmembrane transport
H7K74_RS07300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K74_RS07305	COG0444	Belongs to the ABC transporter superfamily
H7K74_RS07310	COG4608	Belongs to the ABC transporter superfamily
H7K74_RS07330	COG3706	GGDEF domain
H7K74_RS07330	COG2203	Gaf domain
H7K74_RS07330	COG5001	Diguanylate cyclase
H7K74_RS07330	COG4251	negative regulation of phosphorylation
H7K74_RS07335	COG3360	Dodecin
H7K74_RS07340	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
H7K74_RS07340	COG2273	Hydrolase Family 16
H7K74_RS07345	COG2723	6-phospho-beta-galactosidase activity
H7K74_RS07380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7K74_RS07385	COG2198	Histidine kinase
H7K74_RS07385	COG2205	protein histidine kinase activity
H7K74_RS07385	COG0784	Response regulator, receiver
H7K74_RS07405	COG2086	electron transfer activity
H7K74_RS07410	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H7K74_RS07415	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7K74_RS07425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7K74_RS07430	COG0165	Argininosuccinate lyase
H7K74_RS07440	COG0019	diaminopimelate decarboxylase activity
H7K74_RS07450	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7K74_RS07465	COG2204	response regulator
H7K74_RS07475	COG2884	Cell division ATP-binding protein ftsE
H7K74_RS07505	COG0287	Prephenate dehydrogenase
H7K74_RS07510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7K74_RS07520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7K74_RS07525	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7K74_RS07525	COG2813	Specifically methylates the guanine in position
H7K74_RS07530	COG0596	Alpha beta hydrolase
H7K74_RS07545	COG0542	response to heat
H7K74_RS07560	COG0739	heme binding
H7K74_RS07600	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS07605	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H7K74_RS07620	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H7K74_RS07625	COG0640	Transcriptional regulator
H7K74_RS07655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7K74_RS07660	COG1605	Chorismate mutase
H7K74_RS07660	COG0077	Prephenate dehydratase
H7K74_RS07665	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H7K74_RS07670	COG3474	cytochrome
H7K74_RS07675	COG4166	transmembrane transport
H7K74_RS07680	COG4166	transmembrane transport
H7K74_RS07685	COG4174	ABC transporter (Permease)
H7K74_RS07690	COG4239	(ABC) transporter, permease
H7K74_RS07695	COG4172	Belongs to the ABC transporter superfamily
H7K74_RS07715	COG0791	NLP P60 protein
H7K74_RS07720	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7K74_RS07760	COG4964	Belongs to the GSP D family
H7K74_RS07795	COG1278	Cold shock
H7K74_RS07800	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H7K74_RS07805	COG0513	Belongs to the DEAD box helicase family
H7K74_RS07835	COG0829	nickel cation binding
H7K74_RS07840	COG0831	urea catabolic process
H7K74_RS07845	COG0832	Belongs to the urease beta subunit family
H7K74_RS07850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7K74_RS07855	COG0804	urea catabolic process
H7K74_RS07870	COG0830	nickel cation binding
H7K74_RS07875	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H7K74_RS07885	COG0251	oxidation-reduction process
H7K74_RS07910	COG0628	permease
H7K74_RS07915	COG1376	ErfK ybiS ycfS ynhG family protein
H7K74_RS07915	COG1388	LysM domain
H7K74_RS07940	COG3237	CsbD-like
H7K74_RS07945	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H7K74_RS07960	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7K74_RS07960	COG1648	precorrin-2 dehydrogenase activity
H7K74_RS07970	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7K74_RS07980	COG0175	sulfate reduction
H7K74_RS07985	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H7K74_RS07990	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H7K74_RS07995	COG4208	sulfate ABC transporter
H7K74_RS08000	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H7K74_RS08015	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS08020	COG0730	response to heat
H7K74_RS08035	COG1678	Uncharacterized ACR, COG1678
H7K74_RS08045	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS08050	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS08055	COG3237	CsbD-like
H7K74_RS08065	COG2951	lytic endotransglycosylase activity
H7K74_RS08070	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H7K74_RS08075	COG2203	Gaf domain
H7K74_RS08075	COG3706	GGDEF domain
H7K74_RS08075	COG4251	negative regulation of phosphorylation
H7K74_RS08075	COG5001	Diguanylate cyclase
H7K74_RS08090	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS08090	COG0604	alcohol dehydrogenase
H7K74_RS08090	COG3321	synthase
H7K74_RS08105	COG0254	rRNA binding
H7K74_RS08110	COG1132	(ABC) transporter
H7K74_RS08135	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H7K74_RS08145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K74_RS08150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K74_RS08155	COG0483	inositol monophosphate 1-phosphatase activity
H7K74_RS08170	COG3588	fructose-bisphosphate aldolase
H7K74_RS08180	COG0126	phosphoglycerate kinase activity
H7K74_RS08215	COG1692	metallophosphoesterase
H7K74_RS08245	COG0217	transcriptional regulatory protein
H7K74_RS08250	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H7K74_RS08255	COG0632	four-way junction helicase activity
H7K74_RS08260	COG2255	four-way junction helicase activity
H7K74_RS08270	COG1408	metallophosphoesterase
H7K74_RS08340	COG5001	Diguanylate cyclase
H7K74_RS08345	COG1858	cytochrome C peroxidase
H7K74_RS08450	COG0747	negative chemotaxis
H7K74_RS08455	COG0601	transmembrane transport
H7K74_RS08460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K74_RS08510	COG4227	nucleotidyltransferase activity
H7K74_RS08570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K74_RS08575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7K74_RS08585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H7K74_RS08710	COG0765	amino acid transport
H7K74_RS08730	COG4886	Leucine-rich repeat (LRR) protein
H7K74_RS08915	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7K74_RS08935	COG3436	PFAM IS66 Orf2 family protein
H7K74_RS08955	COG3831	ATPase activity
H7K74_RS08985	COG4566	intracellular signal transduction
H7K74_RS08990	COG4566	intracellular signal transduction
H7K74_RS08995	COG4191	Histidine kinase
H7K74_RS09010	COG1301	dicarboxylic acid transport
H7K74_RS09020	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
H7K74_RS09025	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
H7K74_RS09030	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
H7K74_RS09040	COG0298	carbon dioxide binding
H7K74_RS09045	COG1773	rubredoxin
H7K74_RS09055	COG0375	protein maturation
H7K74_RS09070	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
H7K74_RS09070	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
H7K74_RS09075	COG0409	Hydrogenase expression formation protein
H7K74_RS09080	COG0309	Hydrogenase expression formation protein (HypE)
H7K74_RS09085	COG0686	Belongs to the AlaDH PNT family
H7K74_RS09090	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7K74_RS09105	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H7K74_RS09110	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H7K74_RS09115	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H7K74_RS09120	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H7K74_RS09135	COG5420	small protein containing a coiled-coil domain
H7K74_RS09160	COG0316	Belongs to the HesB IscA family
H7K74_RS09170	COG1104	cysteine desulfurase activity
H7K74_RS09175	COG5554	nitrogen fixation
H7K74_RS09180	COG0535	radical SAM domain protein
H7K74_RS09185	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7K74_RS09190	COG5554	nitrogen fixation
H7K74_RS09210	COG3411	Ferredoxin
H7K74_RS09215	COG3047	cAMP biosynthetic process
H7K74_RS09230	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
H7K74_RS09245	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H7K74_RS09250	COG0644	oxidoreductase
H7K74_RS09255	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H7K74_RS09260	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7K74_RS09275	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H7K74_RS09305	COG0612	Peptidase, M16
H7K74_RS09315	COG5010	COG0457 FOG TPR repeat
H7K74_RS09320	COG4789	Type iii secretion
H7K74_RS09385	COG4669	(LipO)protein
H7K74_RS09395	COG1317	bacterial-type flagellum organization
H7K74_RS09400	COG1157	protein secretion by the type III secretion system
H7K74_RS09410	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7K74_RS09415	COG4790	Type iii secretion
H7K74_RS09420	COG4794	Type iii secretion
H7K74_RS09425	COG4791	protein targeting
H7K74_RS09430	COG4792	protein secretion
H7K74_RS09525	COG5461	TIGRFAM pilus (Caulobacter type) biogenesis lipoprotein CpaD
H7K74_RS09530	COG4964	Belongs to the GSP D family
H7K74_RS09535	COG0745	RESPONSE REGULATOR receiver
H7K74_RS09560	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H7K74_RS09575	COG2801	Transposase and inactivated derivatives
H7K74_RS09580	COG3293	Transposase
H7K74_RS09655	COG2771	luxR family
H7K74_RS09660	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H7K74_RS09695	COG1175	transmembrane transport
H7K74_RS09700	COG0395	ABC-type sugar transport system, permease component
H7K74_RS09705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7K74_RS09710	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS09725	COG2204	response regulator
H7K74_RS09725	COG5564	TIM-barrel signal transduction protein
H7K74_RS09740	COG5564	TIM-barrel signal transduction protein
H7K74_RS09745	COG1053	succinate dehydrogenase
H7K74_RS09790	COG1024	Enoyl-CoA hydratase
H7K74_RS09795	COG0477	Major facilitator Superfamily
H7K74_RS09805	COG1609	Transcriptional regulator
H7K74_RS09850	COG0436	Aminotransferase
H7K74_RS09875	COG3591	Belongs to the peptidase S1B family
H7K74_RS09940	COG3550	peptidyl-serine autophosphorylation
H7K74_RS10015	COG5564	TIM-barrel signal transduction protein
H7K74_RS10020	COG1053	succinate dehydrogenase
H7K74_RS10025	COG1522	sequence-specific DNA binding
H7K74_RS10155	COG2188	Transcriptional regulator
H7K74_RS10160	COG4750	Nucleotidyl transferase
H7K74_RS10170	COG2771	luxR family
H7K74_RS10215	COG1505	serine-type exopeptidase activity
H7K74_RS10220	COG1278	Cold shock
H7K74_RS10230	COG2814	Major facilitator Superfamily
H7K74_RS10315	COG4886	Leucine-rich repeat (LRR) protein
H7K74_RS10370	COG0419	ATPase involved in DNA repair
H7K74_RS10375	COG0420	3'-5' exonuclease activity
H7K74_RS10450	COG2801	Transposase and inactivated derivatives
H7K74_RS10490	COG1278	Cold shock
H7K74_RS10495	COG5489	Protein of unknown function (DUF736)
H7K74_RS10620	COG3550	peptidyl-serine autophosphorylation
H7K74_RS10700	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7K74_RS10710	COG2771	luxR family
H7K74_RS10740	COG0789	Transcriptional regulator
H7K74_RS10750	COG0583	DNA-binding transcription factor activity
H7K74_RS10755	COG0583	DNA-binding transcription factor activity
H7K74_RS10760	COG3153	acetyltransferase
H7K74_RS10770	COG1215	transferase activity, transferring glycosyl groups
H7K74_RS10775	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7K74_RS10780	COG2192	nodulation
H7K74_RS10785	COG1131	(ABC) transporter
H7K74_RS10790	COG0842	Transport permease protein
H7K74_RS10795	COG2192	nodulation
H7K74_RS10800	COG2192	nodulation
H7K74_RS10810	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS10815	COG3604	Transcriptional regulator
H7K74_RS10820	COG2086	electron transfer activity
H7K74_RS10860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H7K74_RS10875	COG3344	reverse transcriptase
H7K74_RS10895	COG0459	protein refolding
H7K74_RS10900	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H7K74_RS10905	COG0275	rRNA processing
H7K74_RS10935	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H7K74_RS10965	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H7K74_RS10980	COG0174	glutamine synthetase
H7K74_RS11015	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H7K74_RS11030	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H7K74_RS11035	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H7K74_RS11040	COG0156	8-amino-7-oxononanoate synthase activity
H7K74_RS11045	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H7K74_RS11050	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7K74_RS11055	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H7K74_RS11060	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H7K74_RS11085	COG0662	Cupin 2, conserved barrel domain protein
H7K74_RS11145	COG1278	Cold shock
H7K74_RS11220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7K74_RS11220	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7K74_RS11225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7K74_RS11235	COG0582	viral genome integration into host DNA
H7K74_RS11240	COG4974	Belongs to the 'phage' integrase family
H7K74_RS11265	COG2124	cytochrome p450
H7K74_RS11270	COG2124	cytochrome p450
H7K74_RS11280	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS11285	COG2124	cytochrome p450
H7K74_RS11290	COG0142	geranyltranstransferase activity
H7K74_RS11295	COG1657	PFAM Prenyltransferase squalene oxidase
H7K74_RS11345	COG3328	transposase activity
H7K74_RS11360	COG0583	DNA-binding transcription factor activity
H7K74_RS11365	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS11370	COG3959	Transketolase, thiamine diphosphate binding domain
H7K74_RS11375	COG3958	Transketolase
H7K74_RS11380	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H7K74_RS11405	COG0784	Response regulator, receiver
H7K74_RS11405	COG4191	Histidine kinase
H7K74_RS11410	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H7K74_RS11415	COG4191	Histidine kinase
H7K74_RS11415	COG0784	Response regulator, receiver
H7K74_RS11425	COG3920	Histidine kinase
H7K74_RS11465	COG1218	3'(2'),5'-bisphosphate nucleotidase
H7K74_RS11475	COG0784	Response regulator, receiver
H7K74_RS11475	COG2198	Histidine kinase
H7K74_RS11475	COG0643	Histidine kinase
H7K74_RS11480	COG0835	chemotaxis
H7K74_RS11485	COG0643	Histidine kinase
H7K74_RS11485	COG2198	Histidine kinase
H7K74_RS11485	COG0784	Response regulator, receiver
H7K74_RS11490	COG2201	protein-glutamate methylesterase activity
H7K74_RS11505	COG0754	glutathionylspermidine amidase activity
H7K74_RS11515	COG3766	membrane
H7K74_RS11535	COG1595	DNA-templated transcription, initiation
H7K74_RS11560	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H7K74_RS11605	COG1309	transcriptional regulator
H7K74_RS11610	COG2080	2 iron, 2 sulfur cluster binding
H7K74_RS11615	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H7K74_RS11620	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7K74_RS11630	COG3620	sequence-specific DNA binding
H7K74_RS11635	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7K74_RS11640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K74_RS11650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K74_RS11655	COG0765	amino acid transport
H7K74_RS11660	COG1126	abc transporter atp-binding protein
H7K74_RS11665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K74_RS11675	COG0405	Gamma-glutamyltransferase
H7K74_RS11680	COG1024	Enoyl-CoA hydratase
H7K74_RS11735	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7K74_RS11810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7K74_RS11835	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7K74_RS11905	COG1129	ABC transporter
H7K74_RS11910	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7K74_RS11920	COG1335	isochorismatase
H7K74_RS11925	COG0583	DNA-binding transcription factor activity
H7K74_RS11965	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7K74_RS12035	COG0303	'Molybdopterin
H7K74_RS12045	COG0746	molybdenum cofactor guanylyltransferase activity
H7K74_RS12055	COG1763	Mo-molybdopterin cofactor biosynthetic process
H7K74_RS12070	COG2223	nitrite transmembrane transporter activity
H7K74_RS12080	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H7K74_RS12085	COG3383	formate dehydrogenase (NAD+) activity
H7K74_RS12090	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H7K74_RS12130	COG5002	protein histidine kinase activity
H7K74_RS12130	COG5001	Diguanylate cyclase
H7K74_RS12130	COG3447	MASE1 domain protein
H7K74_RS12135	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H7K74_RS12145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7K74_RS12150	COG0346	lactoylglutathione lyase activity
H7K74_RS12160	COG0583	DNA-binding transcription factor activity
H7K74_RS12165	COG3485	protocatechuate 3,4-dioxygenase
H7K74_RS12170	COG3485	protocatechuate 3,4-dioxygenase
H7K74_RS12210	COG0745	RESPONSE REGULATOR receiver
H7K74_RS12215	COG2198	Histidine kinase
H7K74_RS12215	COG0643	Histidine kinase
H7K74_RS12220	COG0835	chemotaxis
H7K74_RS12225	COG0840	transmembrane signaling receptor activity
H7K74_RS12230	COG0835	chemotaxis
H7K74_RS12235	COG0840	transmembrane signaling receptor activity
H7K74_RS12245	COG2201	protein-glutamate methylesterase activity
H7K74_RS12290	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H7K74_RS12300	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H7K74_RS12320	COG3206	protein involved in exopolysaccharide biosynthesis
H7K74_RS12320	COG0489	protein tyrosine kinase activity
H7K74_RS12345	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H7K74_RS12345	COG2755	lipolytic protein G-D-S-L family
H7K74_RS12355	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H7K74_RS12360	COG2244	polysaccharide biosynthetic process
H7K74_RS12365	COG1045	serine acetyltransferase
H7K74_RS12370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7K74_RS12380	COG0438	transferase activity, transferring glycosyl groups
H7K74_RS12430	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H7K74_RS12460	COG3474	cytochrome
H7K74_RS12480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7K74_RS12495	COG3300	MHYT domain
H7K74_RS12495	COG5001	Diguanylate cyclase
H7K74_RS12505	COG1309	transcriptional regulator
H7K74_RS12515	COG0181	hydroxymethylbilane synthase activity
H7K74_RS12520	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H7K74_RS12530	COG5001	Diguanylate cyclase
H7K74_RS12530	COG3706	GGDEF domain
H7K74_RS12530	COG4251	negative regulation of phosphorylation
H7K74_RS12530	COG2203	Gaf domain
H7K74_RS12535	COG2900	Belongs to the SlyX family
H7K74_RS12540	COG1054	Belongs to the UPF0176 family
H7K74_RS12545	COG0405	Gamma-glutamyltransferase
H7K74_RS12555	COG3237	CsbD-like
H7K74_RS12595	COG2885	chlorophyll binding
H7K74_RS12595	COG3047	cAMP biosynthetic process
H7K74_RS12615	COG3214	Protein conserved in bacteria
H7K74_RS12640	COG1309	transcriptional regulator
H7K74_RS12660	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7K74_RS12660	COG1024	Enoyl-CoA hydratase
H7K74_RS12670	COG1607	acyl-coa hydrolase
H7K74_RS12690	COG1349	DNA-binding transcription factor activity
H7K74_RS12710	COG3842	ATPase activity
H7K74_RS12715	COG3842	ATPase activity
H7K74_RS12725	COG0395	ABC-type sugar transport system, permease component
H7K74_RS12745	COG2197	response regulator
H7K74_RS12750	COG1902	pentaerythritol trinitrate reductase activity
H7K74_RS12775	COG0501	Belongs to the peptidase M48B family
H7K74_RS12825	COG0494	nUDIX hydrolase
H7K74_RS12830	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H7K74_RS12835	COG4771	TonB-dependent receptor
H7K74_RS12860	COG0714	Associated with various cellular activities
H7K74_RS12880	COG0617	tRNA 3'-terminal CCA addition
H7K74_RS12910	COG1396	sequence-specific DNA binding
H7K74_RS12910	COG1917	Cupin 2, conserved barrel domain protein
H7K74_RS12915	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H7K74_RS12920	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
H7K74_RS12930	COG3293	Transposase
H7K74_RS12955	COG0408	coproporphyrinogen oxidase activity
H7K74_RS12965	COG0602	queuosine metabolic process
H7K74_RS12970	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H7K74_RS12975	COG0723	plastoquinol--plastocyanin reductase activity
H7K74_RS12980	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H7K74_RS12980	COG2857	Cytochrome c1
H7K74_RS13000	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7K74_RS13020	COG1704	LemA family
H7K74_RS13030	COG1196	nuclear chromosome segregation
H7K74_RS13035	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7K74_RS13035	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7K74_RS13045	COG1194	a g-specific adenine glycosylase
H7K74_RS13070	COG0625	glutathione transferase activity
H7K74_RS13090	COG0840	transmembrane signaling receptor activity
H7K74_RS13095	COG0840	transmembrane signaling receptor activity
H7K74_RS13100	COG0625	glutathione transferase activity
H7K74_RS13110	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H7K74_RS13115	COG2321	neutral zinc metallopeptidase
H7K74_RS13120	COG0521	Mo-molybdopterin cofactor biosynthetic process
H7K74_RS13130	COG0456	acetyltransferase
H7K74_RS13130	COG1846	Transcriptional regulator
H7K74_RS13145	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7K74_RS13145	COG0574	Belongs to the PEP-utilizing enzyme family
H7K74_RS13160	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
H7K74_RS13175	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H7K74_RS13185	COG1573	uracil-dna glycosylase
H7K74_RS13200	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H7K74_RS13210	COG1280	lysine exporter protein (LysE YggA)
H7K74_RS13215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7K74_RS13225	COG0142	geranyltranstransferase activity
H7K74_RS13250	COG0752	glycyl-tRNA synthetase alpha subunit
H7K74_RS13255	COG0751	glycine-tRNA ligase activity
H7K74_RS13270	COG0574	Belongs to the PEP-utilizing enzyme family
H7K74_RS13270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7K74_RS13285	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H7K74_RS13290	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H7K74_RS13300	COG0604	alcohol dehydrogenase
H7K74_RS13320	COG0840	transmembrane signaling receptor activity
H7K74_RS13350	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
H7K74_RS13355	COG0519	Catalyzes the synthesis of GMP from XMP
H7K74_RS13360	COG0354	folic acid binding
H7K74_RS13365	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7K74_RS13370	COG2897	thiosulfate sulfurtransferase activity
H7K74_RS13375	COG1595	DNA-templated transcription, initiation
H7K74_RS13410	COG2135	peptidase activity
H7K74_RS13425	COG0494	nUDIX hydrolase
H7K74_RS13435	COG0277	FAD linked oxidase domain protein
H7K74_RS13440	COG0009	L-threonylcarbamoyladenylate synthase
H7K74_RS13480	COG1309	transcriptional regulator
H7K74_RS13485	COG2814	Major facilitator Superfamily
H7K74_RS13505	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H7K74_RS13525	COG1850	ribulose-bisphosphate carboxylase activity
H7K74_RS13530	COG4451	ribulose bisphosphate carboxylase, small
H7K74_RS13545	COG3300	MHYT domain
H7K74_RS13545	COG5001	Diguanylate cyclase
H7K74_RS13610	COG3850	Histidine kinase
H7K74_RS13610	COG3437	response regulator, receiver
H7K74_RS13610	COG2205	protein histidine kinase activity
H7K74_RS13610	COG4999	Histidine kinase
H7K74_RS13700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7K74_RS13710	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H7K74_RS13710	COG0475	glutathione-regulated potassium exporter activity
H7K74_RS13720	COG1960	acyl-CoA dehydrogenase activity
H7K74_RS13735	COG0318	PFAM AMP-dependent synthetase and ligase
H7K74_RS13750	COG0598	Magnesium transport protein CorA
H7K74_RS13760	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS13765	COG0259	pyridoxamine-phosphate oxidase activity
H7K74_RS13790	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7K74_RS13800	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H7K74_RS13810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7K74_RS13825	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H7K74_RS13830	COG1993	acr, cog1993
H7K74_RS13835	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H7K74_RS13840	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H7K74_RS13860	COG1024	Enoyl-CoA hydratase
H7K74_RS13885	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7K74_RS13890	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H7K74_RS13900	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H7K74_RS13905	COG1722	exodeoxyribonuclease VII activity
H7K74_RS13910	COG0123	including yeast histone deacetylase and acetoin utilization protein
H7K74_RS13915	COG4085	toxin activity
H7K74_RS13915	COG1525	nuclease
H7K74_RS13915	COG0737	Belongs to the 5'-nucleotidase family
H7K74_RS13930	COG2223	nitrite transmembrane transporter activity
H7K74_RS13935	COG1960	acyl-CoA dehydrogenase activity
H7K74_RS13970	COG3119	arylsulfatase activity
H7K74_RS14020	COG1879	ABC-type sugar transport system periplasmic component
H7K74_RS14025	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7K74_RS14030	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7K74_RS14035	COG1129	ABC transporter
H7K74_RS14040	COG0277	FAD linked oxidase domain protein
H7K74_RS14045	COG3485	protocatechuate 3,4-dioxygenase
H7K74_RS14050	COG2084	Dehydrogenase
H7K74_RS14055	COG0402	S-adenosylhomocysteine deaminase activity
H7K74_RS14070	COG0583	DNA-binding transcription factor activity
H7K74_RS14085	COG0477	Major facilitator Superfamily
H7K74_RS14090	COG1012	belongs to the aldehyde dehydrogenase family
H7K74_RS14100	COG2814	Major facilitator Superfamily
H7K74_RS14125	COG1858	cytochrome C peroxidase
H7K74_RS14140	COG1473	amidohydrolase
H7K74_RS14185	COG0741	lytic transglycosylase activity
H7K74_RS14235	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7K74_RS14245	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H7K74_RS14265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7K74_RS14270	COG1053	succinate dehydrogenase
H7K74_RS14285	COG1335	isochorismatase
H7K74_RS14305	COG3833	ABC-type maltose transport systems, permease component
H7K74_RS14310	COG1175	transmembrane transport
H7K74_RS14315	COG1653	transport
H7K74_RS14320	COG3258	Cytochrome c
H7K74_RS14340	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7K74_RS14345	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7K74_RS14345	COG2010	Cytochrome c
H7K74_RS14360	COG1032	radical SAM domain protein
H7K74_RS14365	COG2814	Major facilitator Superfamily
H7K74_RS14370	COG0473	3-isopropylmalate dehydrogenase activity
H7K74_RS14395	COG2264	protein methyltransferase activity
H7K74_RS14405	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS14410	COG4106	trans-aconitate 2-methyltransferase activity
H7K74_RS14425	COG2015	COG2015, Alkyl sulfatase and related hydrolases
H7K74_RS14430	COG0438	transferase activity, transferring glycosyl groups
H7K74_RS14435	COG1132	(ABC) transporter
H7K74_RS14455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7K74_RS14460	COG0745	RESPONSE REGULATOR receiver
H7K74_RS14465	COG4566	intracellular signal transduction
H7K74_RS14470	COG4191	Histidine kinase
H7K74_RS14480	COG0516	GMP reductase activity
H7K74_RS14480	COG0517	IMP dehydrogenase activity
H7K74_RS14485	COG3278	Belongs to the heme-copper respiratory oxidase family
H7K74_RS14500	COG2010	Cytochrome c
H7K74_RS14515	COG2217	Heavy metal translocating P-type atpase
H7K74_RS14545	COG0583	DNA-binding transcription factor activity
H7K74_RS14560	COG0297	glycogen (starch) synthase activity
H7K74_RS14575	COG0473	3-isopropylmalate dehydrogenase activity
H7K74_RS14585	COG1024	Enoyl-CoA hydratase
H7K74_RS14590	COG2989	Protein conserved in bacteria
H7K74_RS14595	COG1396	sequence-specific DNA binding
H7K74_RS14610	COG0785	Cytochrome C biogenesis protein
H7K74_RS14615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7K74_RS14620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7K74_RS14635	COG2207	Transcriptional regulator
H7K74_RS14660	COG3485	protocatechuate 3,4-dioxygenase
H7K74_RS14665	COG0515	serine threonine protein kinase
H7K74_RS14675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7K74_RS14680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K74_RS14685	COG1116	anion transmembrane transporter activity
H7K74_RS14690	COG2223	nitrite transmembrane transporter activity
H7K74_RS14695	COG1017	nitric oxide dioxygenase activity
H7K74_RS14695	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7K74_RS14700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7K74_RS14705	COG0243	molybdopterin cofactor binding
H7K74_RS14710	COG0656	L-ascorbic acid biosynthetic process
H7K74_RS14720	COG1063	alcohol dehydrogenase
H7K74_RS14730	COG1522	sequence-specific DNA binding
H7K74_RS14735	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H7K74_RS14750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7K74_RS14790	COG0129	dihydroxy-acid dehydratase activity
H7K74_RS14820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7K74_RS14825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7K74_RS14835	COG1309	transcriptional regulator
H7K74_RS14840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K74_RS14860	COG0673	inositol 2-dehydrogenase activity
H7K74_RS14910	COG1980	fructose-bisphosphate aldolase activity
H7K74_RS14920	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H7K74_RS14930	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7K74_RS14935	COG2124	cytochrome p450
H7K74_RS14945	COG0028	Belongs to the TPP enzyme family
H7K74_RS14945	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
H7K74_RS14955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K74_RS14960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K74_RS14975	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H7K74_RS14985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K74_RS14990	COG0601	transmembrane transport
H7K74_RS14995	COG0747	negative chemotaxis
H7K74_RS15000	COG4608	Belongs to the ABC transporter superfamily
H7K74_RS15005	COG0444	Belongs to the ABC transporter superfamily
H7K74_RS15025	COG0444	Belongs to the ABC transporter superfamily
H7K74_RS15030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K74_RS15040	COG0747	negative chemotaxis
H7K74_RS15060	COG2267	carboxylic ester hydrolase activity
H7K74_RS15065	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7K74_RS15065	COG2124	cytochrome p450
H7K74_RS15100	COG2733	membrane
H7K74_RS15105	COG0596	Alpha beta hydrolase
H7K74_RS15110	COG3327	negative regulation of DNA-templated transcription, initiation
H7K74_RS15115	COG3396	Phenylacetate-CoA oxygenase
H7K74_RS15120	COG3460	Phenylacetate-CoA oxygenase
H7K74_RS15125	COG3396	Phenylacetate-CoA oxygenase
H7K74_RS15130	COG2151	metal-sulfur cluster biosynthetic enzyme
H7K74_RS15135	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7K74_RS15140	COG2050	protein possibly involved in aromatic compounds catabolism
H7K74_RS15175	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H7K74_RS15180	COG0477	Major facilitator Superfamily
H7K74_RS15205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K74_RS15210	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7K74_RS15220	COG4597	amino acid ABC transporter
H7K74_RS15225	COG0765	amino acid transport
H7K74_RS15235	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS15240	COG0473	3-isopropylmalate dehydrogenase activity
H7K74_RS15245	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H7K74_RS15250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7K74_RS15260	COG0583	DNA-binding transcription factor activity
H7K74_RS15265	COG4336	lyase activity
H7K74_RS15295	COG0235	Class ii aldolase
H7K74_RS15300	COG2084	Dehydrogenase
H7K74_RS15305	COG3622	Belongs to the hyi family
H7K74_RS15310	COG3395	kinase activity
H7K74_RS15315	COG0840	transmembrane signaling receptor activity
H7K74_RS15320	COG0840	transmembrane signaling receptor activity
H7K74_RS15325	COG0840	transmembrane signaling receptor activity
H7K74_RS15325	COG0840	transmembrane signaling receptor activity
H7K74_RS15345	COG2070	2-Nitropropane dioxygenase
H7K74_RS15350	COG2072	flavoprotein involved in K transport
H7K74_RS15355	COG0625	glutathione transferase activity
H7K74_RS15370	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS15375	COG1024	Enoyl-CoA hydratase
H7K74_RS15390	COG1024	Enoyl-CoA hydratase
H7K74_RS15395	COG1960	acyl-CoA dehydrogenase activity
H7K74_RS15400	COG0318	PFAM AMP-dependent synthetase and ligase
H7K74_RS15410	COG1024	Enoyl-CoA hydratase
H7K74_RS15420	COG1024	Enoyl-CoA hydratase
H7K74_RS15435	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H7K74_RS15440	COG3386	PFAM SMP-30 Gluconolaconase
H7K74_RS15445	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS15475	COG3145	DNA-N1-methyladenine dioxygenase activity
H7K74_RS15485	COG0028	Belongs to the TPP enzyme family
H7K74_RS15490	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7K74_RS15500	COG1012	belongs to the aldehyde dehydrogenase family
H7K74_RS15510	COG3971	2-oxopent-4-enoate hydratase activity
H7K74_RS15515	COG1846	Transcriptional regulator
H7K74_RS15530	COG2721	sulfolactate sulfo-lyase activity
H7K74_RS15615	COG4303	Ethanolamine ammonia lyase large subunit
H7K74_RS15625	COG4302	ethanolamine ammonia-lyase activity
H7K74_RS15650	COG1562	ergosterol biosynthetic process
H7K74_RS15655	COG1562	ergosterol biosynthetic process
H7K74_RS15660	COG1233	COG1233 Phytoene dehydrogenase and related
H7K74_RS15665	COG1657	PFAM Prenyltransferase squalene oxidase
H7K74_RS15670	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H7K74_RS15680	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H7K74_RS15715	COG1595	DNA-templated transcription, initiation
H7K74_RS15750	COG1473	amidohydrolase
H7K74_RS15755	COG0306	phosphate transporter
H7K74_RS15760	COG1573	uracil-dna glycosylase
H7K74_RS15775	COG0587	DNA-directed DNA polymerase activity
H7K74_RS15780	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS15790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7K74_RS15820	COG1024	Enoyl-CoA hydratase
H7K74_RS15880	COG1703	isobutyryl-CoA mutase activity
H7K74_RS15925	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H7K74_RS15935	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H7K74_RS15950	COG0433	COG0433 Predicted ATPase
H7K74_RS15980	COG4957	zinc ion binding
H7K74_RS15985	COG2166	iron-sulfur cluster assembly
H7K74_RS15995	COG2205	protein histidine kinase activity
H7K74_RS16030	COG0583	DNA-binding transcription factor activity
H7K74_RS16075	COG0798	PFAM Bile acid sodium symporter
H7K74_RS16125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H7K74_RS16135	COG0765	amino acid transport
H7K74_RS16140	COG0765	amino acid transport
H7K74_RS16145	COG1126	abc transporter atp-binding protein
H7K74_RS16165	COG2983	Belongs to the UPF0260 family
H7K74_RS16170	COG0477	Major facilitator Superfamily
H7K74_RS16180	COG4191	Histidine kinase
H7K74_RS16180	COG0784	Response regulator, receiver
H7K74_RS16185	COG0028	Belongs to the TPP enzyme family
H7K74_RS16210	COG0463	Glycosyl transferase, family 2
H7K74_RS16225	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H7K74_RS16230	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H7K74_RS16235	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H7K74_RS16255	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H7K74_RS16285	COG4235	cytochrome complex assembly
H7K74_RS16290	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H7K74_RS16295	COG1138	Cytochrome C-type biogenesis protein
H7K74_RS16300	COG3088	subunit of a heme lyase
H7K74_RS16315	COG0745	RESPONSE REGULATOR receiver
H7K74_RS16320	COG2205	protein histidine kinase activity
H7K74_RS16325	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H7K74_RS16335	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H7K74_RS16340	COG3383	formate dehydrogenase (NAD+) activity
H7K74_RS16355	COG0583	DNA-binding transcription factor activity
H7K74_RS16360	COG2202	Pas domain
H7K74_RS16360	COG2205	protein histidine kinase activity
H7K74_RS16365	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H7K74_RS16370	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS16370	COG3321	synthase
H7K74_RS16370	COG0604	alcohol dehydrogenase
H7K74_RS16395	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7K74_RS16400	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H7K74_RS16425	COG0443	Heat shock 70 kDa protein
H7K74_RS16435	COG1278	Cold shock
H7K74_RS16455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7K74_RS16465	COG1802	Transcriptional regulator
H7K74_RS16500	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H7K74_RS16505	COG3960	tartronate-semialdehyde synthase activity
H7K74_RS16510	COG3622	Belongs to the hyi family
H7K74_RS16515	COG2084	Dehydrogenase
H7K74_RS16540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7K74_RS16560	COG1982	Orn Lys Arg decarboxylase major
H7K74_RS16565	COG1522	sequence-specific DNA binding
H7K74_RS16570	COG0686	Belongs to the AlaDH PNT family
H7K74_RS16575	COG2072	flavoprotein involved in K transport
H7K74_RS16580	COG1309	transcriptional regulator
H7K74_RS16610	COG0410	ABC transporter
H7K74_RS16620	COG2855	membrane
H7K74_RS16625	COG1116	anion transmembrane transporter activity
H7K74_RS16630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K74_RS16635	COG4521	taurine ABC transporter
H7K74_RS16640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7K74_RS16655	COG1053	succinate dehydrogenase
H7K74_RS16675	COG1879	ABC-type sugar transport system periplasmic component
H7K74_RS16680	COG1129	ABC transporter
H7K74_RS16685	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7K74_RS16690	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7K74_RS16710	COG3386	PFAM SMP-30 Gluconolaconase
H7K74_RS16715	COG4213	ABC transporter substrate-binding protein
H7K74_RS16720	COG1129	ABC transporter
H7K74_RS16725	COG4214	carbohydrate transport
H7K74_RS16735	COG1845	cytochrome c oxidase, subunit III
H7K74_RS16750	COG3256	nitric oxide reductase
H7K74_RS16755	COG0714	Associated with various cellular activities
H7K74_RS16765	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7K74_RS16795	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS16825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K74_RS16835	COG4608	Belongs to the ABC transporter superfamily
H7K74_RS16840	COG0747	negative chemotaxis
H7K74_RS16875	COG3842	ATPase activity
H7K74_RS16880	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H7K74_RS16885	COG1177	transmembrane transport
H7K74_RS16890	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7K74_RS16900	COG0400	carboxylic ester hydrolase activity
H7K74_RS16905	COG0346	lactoylglutathione lyase activity
H7K74_RS16910	COG0583	DNA-binding transcription factor activity
H7K74_RS16940	COG0778	Nitroreductase
H7K74_RS16945	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H7K74_RS16955	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H7K74_RS16965	COG1492	cobalamin metabolic process
H7K74_RS17010	COG2099	Precorrin-6x reductase
H7K74_RS17025	COG2875	Belongs to the precorrin methyltransferase family
H7K74_RS17030	COG1797	cobyrinic acid a,c-diamide synthase activity
H7K74_RS17035	COG1648	precorrin-2 dehydrogenase activity
H7K74_RS17035	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7K74_RS17050	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H7K74_RS17070	COG0154	amidase activity
H7K74_RS17080	COG2351	hydroxyisourate hydrolase activity
H7K74_RS17090	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7K74_RS17095	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H7K74_RS17100	COG3842	ATPase activity
H7K74_RS17105	COG0154	amidase activity
H7K74_RS17115	COG1802	Transcriptional regulator
H7K74_RS17125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K74_RS17130	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H7K74_RS17145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K74_RS17150	COG2030	dehydratase
H7K74_RS17155	COG4670	ketone body catabolic process
H7K74_RS17160	COG1960	acyl-CoA dehydrogenase activity
H7K74_RS17170	COG1609	Transcriptional regulator
H7K74_RS17175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7K74_RS17180	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7K74_RS17200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7K74_RS17215	COG0765	amino acid transport
H7K74_RS17220	COG1126	abc transporter atp-binding protein
H7K74_RS17230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7K74_RS17235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K74_RS17245	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7K74_RS17250	COG0235	Class ii aldolase
H7K74_RS17270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7K74_RS17285	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7K74_RS17305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7K74_RS17310	COG0318	PFAM AMP-dependent synthetase and ligase
H7K74_RS17320	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7K74_RS17340	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS17345	COG2072	flavoprotein involved in K transport
H7K74_RS17350	COG0747	negative chemotaxis
H7K74_RS17355	COG0601	transmembrane transport
H7K74_RS17360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K74_RS17370	COG0747	negative chemotaxis
H7K74_RS17375	COG0601	transmembrane transport
H7K74_RS17380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K74_RS17385	COG0444	Belongs to the ABC transporter superfamily
H7K74_RS17390	COG4608	Belongs to the ABC transporter superfamily
H7K74_RS17410	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7K74_RS17435	COG0559	Belongs to the binding-protein-dependent transport system permease family
H7K74_RS17485	COG0445	tRNA wobble uridine modification
H7K74_RS17500	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H7K74_RS17505	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7K74_RS17510	COG3386	PFAM SMP-30 Gluconolaconase
H7K74_RS17520	COG3618	amidohydrolase
H7K74_RS17565	COG2268	Band 7 protein
H7K74_RS17565	COG2268	Band 7 protein
H7K74_RS17570	COG5564	TIM-barrel signal transduction protein
H7K74_RS17615	COG1175	transmembrane transport
H7K74_RS17620	COG0395	ABC-type sugar transport system, permease component
H7K74_RS17625	COG0673	inositol 2-dehydrogenase activity
H7K74_RS17635	COG1609	Transcriptional regulator
H7K74_RS17645	COG0477	Major facilitator Superfamily
H7K74_RS17650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7K74_RS17655	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7K74_RS17665	COG4638	Rieske (2fe-2S)
H7K74_RS17675	COG0318	PFAM AMP-dependent synthetase and ligase
H7K74_RS17680	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS17690	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7K74_RS17730	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7K74_RS17750	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7K74_RS17755	COG0596	Alpha beta hydrolase
H7K74_RS17765	COG1846	Transcriptional regulator
H7K74_RS17805	COG1764	response to oxidative stress
H7K74_RS17820	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
H7K74_RS17850	COG0251	oxidation-reduction process
H7K74_RS17865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7K74_RS17885	COG3181	Tripartite tricarboxylate transporter family receptor
H7K74_RS17890	COG1024	Enoyl-CoA hydratase
H7K74_RS17905	COG1960	acyl-CoA dehydrogenase activity
H7K74_RS17910	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS17940	COG0628	permease
H7K74_RS17955	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H7K74_RS17960	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7K74_RS17970	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H7K74_RS17975	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H7K74_RS18005	COG4566	intracellular signal transduction
H7K74_RS18025	COG2985	domain, Protein
H7K74_RS18045	COG2985	domain, Protein
H7K74_RS18050	COG2985	domain, Protein
H7K74_RS18090	COG4191	Histidine kinase
H7K74_RS18095	COG3064	Membrane
H7K74_RS18125	COG0489	protein tyrosine kinase activity
H7K74_RS18160	COG4964	Belongs to the GSP D family
H7K74_RS18185	COG0640	Transcriptional regulator
H7K74_RS18195	COG0785	Cytochrome C biogenesis protein
H7K74_RS18230	COG0737	Belongs to the 5'-nucleotidase family
H7K74_RS18235	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H7K74_RS18260	COG2391	methyltransferase activity
H7K74_RS18265	COG2391	methyltransferase activity
H7K74_RS18275	COG0640	Transcriptional regulator
H7K74_RS18300	COG4977	sequence-specific DNA binding
H7K74_RS18300	COG1917	Cupin 2, conserved barrel domain protein
H7K74_RS18325	COG1024	Enoyl-CoA hydratase
H7K74_RS18340	COG3395	kinase activity
H7K74_RS18345	COG0235	Class ii aldolase
H7K74_RS18350	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7K74_RS18355	COG3842	ATPase activity
H7K74_RS18365	COG1177	transmembrane transport
H7K74_RS18415	COG2205	protein histidine kinase activity
H7K74_RS18420	COG0745	RESPONSE REGULATOR receiver
H7K74_RS18455	COG1175	transmembrane transport
H7K74_RS18460	COG0395	ABC-type sugar transport system, permease component
H7K74_RS18480	COG1461	Dihydroxyacetone kinase
H7K74_RS18485	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
H7K74_RS18495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7K74_RS18505	COG2376	Dihydroxyacetone kinase
H7K74_RS18545	COG4797	methyltransferase
H7K74_RS18545	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H7K74_RS18600	COG1716	ATPase activity
H7K74_RS18610	COG2885	chlorophyll binding
H7K74_RS18630	COG0515	serine threonine protein kinase
H7K74_RS18630	COG2815	serine threonine protein kinase
H7K74_RS18705	COG0436	Aminotransferase
H7K74_RS18725	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS18730	COG3836	Belongs to the HpcH HpaI aldolase family
H7K74_RS18745	COG0436	Aminotransferase
H7K74_RS18750	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7K74_RS18765	COG3842	ATPase activity
H7K74_RS18770	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H7K74_RS18775	COG1984	allophanate hydrolase subunit 2
H7K74_RS18780	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H7K74_RS18790	COG1984	allophanate hydrolase subunit 2
H7K74_RS18800	COG0439	Biotin carboxylase
H7K74_RS18805	COG0511	ligase activity, forming carbon-carbon bonds
H7K74_RS18810	COG4221	oxidoreductase activity
H7K74_RS18820	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7K74_RS18855	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7K74_RS18880	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS18895	COG1053	succinate dehydrogenase
H7K74_RS18900	COG1053	succinate dehydrogenase
H7K74_RS18905	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7K74_RS18910	COG0410	ABC transporter
H7K74_RS18915	COG0559	Belongs to the binding-protein-dependent transport system permease family
H7K74_RS18935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7K74_RS18950	COG1053	succinate dehydrogenase
H7K74_RS18965	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS18970	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS18985	COG3350	monooxygenase activity
H7K74_RS19015	COG0459	protein refolding
H7K74_RS19070	COG1595	DNA-templated transcription, initiation
H7K74_RS19075	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7K74_RS19080	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H7K74_RS19100	COG1749	Flagellar hook protein flgE
H7K74_RS19135	COG0577	efflux transmembrane transporter activity
H7K74_RS19135	COG1136	(ABC) transporter
H7K74_RS19155	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7K74_RS19170	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H7K74_RS19180	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7K74_RS19185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7K74_RS19190	COG1301	dicarboxylic acid transport
H7K74_RS19195	COG0183	Belongs to the thiolase family
H7K74_RS19205	COG0281	malic enzyme
H7K74_RS19205	COG0280	phosphate acetyltransferase
H7K74_RS19210	COG1252	NADH dehydrogenase
H7K74_RS19215	COG1271	oxidase subunit
H7K74_RS19220	COG1294	oxidase, subunit
H7K74_RS19230	COG2204	response regulator
H7K74_RS19235	COG3243	poly(R)-hydroxyalkanoic acid synthase
H7K74_RS19240	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7K74_RS19260	COG2202	Pas domain
H7K74_RS19260	COG2205	protein histidine kinase activity
H7K74_RS19265	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H7K74_RS19270	COG2084	Dehydrogenase
H7K74_RS19285	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H7K74_RS19295	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H7K74_RS19310	COG0745	RESPONSE REGULATOR receiver
H7K74_RS19330	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H7K74_RS19335	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H7K74_RS19345	COG0546	phosphoglycolate phosphatase activity
H7K74_RS19350	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H7K74_RS19365	COG3546	catalase activity
H7K74_RS19420	COG0121	glutamine amidotransferase
H7K74_RS19430	COG1017	nitric oxide dioxygenase activity
H7K74_RS19430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7K74_RS19450	COG0861	Integral membrane protein TerC family
H7K74_RS19465	COG0583	DNA-binding transcription factor activity
H7K74_RS19480	COG1012	belongs to the aldehyde dehydrogenase family
H7K74_RS19495	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H7K74_RS19500	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H7K74_RS19525	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7K74_RS19530	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H7K74_RS19550	COG0215	cysteine-tRNA ligase activity
H7K74_RS19560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7K74_RS19575	COG5265	(ABC) transporter
H7K74_RS19580	COG0688	phosphatidylethanolamine metabolic process
H7K74_RS19585	COG1183	phosphatidylcholine synthase activity
H7K74_RS19600	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS19605	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7K74_RS19615	COG3158	transport of potassium into the cell
H7K74_RS19620	COG3158	transport of potassium into the cell
H7K74_RS19630	COG0436	Aminotransferase
H7K74_RS19635	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H7K74_RS19645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7K74_RS19655	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7K74_RS19660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7K74_RS19700	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H7K74_RS19705	COG1285	pathogenesis
H7K74_RS19725	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7K74_RS19725	COG2010	Cytochrome c
H7K74_RS19730	COG2080	2 iron, 2 sulfur cluster binding
H7K74_RS19770	COG1846	Transcriptional regulator
H7K74_RS19825	COG3618	amidohydrolase
H7K74_RS19830	COG1301	dicarboxylic acid transport
H7K74_RS19835	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H7K74_RS19890	COG1289	transmembrane transporter activity
H7K74_RS19910	COG0318	PFAM AMP-dependent synthetase and ligase
H7K74_RS19915	COG2072	flavoprotein involved in K transport
H7K74_RS19920	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7K74_RS19990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K74_RS19995	COG1309	transcriptional regulator
H7K74_RS20005	COG2814	Major facilitator Superfamily
H7K74_RS20010	COG1012	belongs to the aldehyde dehydrogenase family
H7K74_RS20015	COG1802	Transcriptional regulator
H7K74_RS20025	COG0477	Major facilitator Superfamily
H7K74_RS20030	COG0402	S-adenosylhomocysteine deaminase activity
H7K74_RS20040	COG1234	tRNA 3'-trailer cleavage
H7K74_RS20050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7K74_RS20055	COG0277	FAD linked oxidase domain protein
H7K74_RS20060	COG3395	kinase activity
H7K74_RS20065	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H7K74_RS20070	COG1454	alcohol dehydrogenase
H7K74_RS20100	COG5507	3-demethylubiquinone-9 3-methyltransferase
H7K74_RS20125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K74_RS20130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K74_RS20140	COG4774	siderophore transport
H7K74_RS20145	COG3128	pkhd-type hydroxylase
H7K74_RS20155	COG0848	biopolymer transport protein
H7K74_RS20170	COG1994	Peptidase M50
H7K74_RS20180	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H7K74_RS20185	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS20190	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS20195	COG0129	dihydroxy-acid dehydratase activity
H7K74_RS20200	COG1609	Transcriptional regulator
H7K74_RS20205	COG3842	ATPase activity
H7K74_RS20220	COG3833	ABC-type maltose transport systems, permease component
H7K74_RS20225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7K74_RS20230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7K74_RS20235	COG0800	Aldolase
H7K74_RS20240	COG0183	Belongs to the thiolase family
H7K74_RS20250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7K74_RS20255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7K74_RS20265	COG2186	Transcriptional regulator
H7K74_RS20270	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7K74_RS20275	COG0747	negative chemotaxis
H7K74_RS20295	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
H7K74_RS20295	COG2066	Belongs to the glutaminase family
H7K74_RS20310	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H7K74_RS20320	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7K74_RS20360	COG2271	Major facilitator Superfamily
H7K74_RS20365	COG0183	Belongs to the thiolase family
H7K74_RS20370	COG1024	Enoyl-CoA hydratase
H7K74_RS20395	COG1960	acyl-CoA dehydrogenase activity
H7K74_RS20410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7K74_RS20420	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS20425	COG0493	'glutamate synthase
H7K74_RS20425	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7K74_RS20430	COG2814	Major facilitator Superfamily
H7K74_RS20435	COG0583	DNA-binding transcription factor activity
H7K74_RS20445	COG0488	(ABC) transporter
H7K74_RS20450	COG1671	Belongs to the UPF0178 family
H7K74_RS20470	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H7K74_RS20485	COG2130	NADP-dependent
H7K74_RS20495	COG1609	Transcriptional regulator
H7K74_RS20505	COG0251	oxidation-reduction process
H7K74_RS20510	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H7K74_RS20520	COG0765	amino acid transport
H7K74_RS20525	COG0765	amino acid transport
H7K74_RS20555	COG1278	Cold shock
H7K74_RS20570	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7K74_RS20570	COG0519	Catalyzes the synthesis of GMP from XMP
H7K74_RS20580	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS20585	COG0583	DNA-binding transcription factor activity
H7K74_RS20595	COG1510	regulation of RNA biosynthetic process
H7K74_RS20615	COG1012	belongs to the aldehyde dehydrogenase family
H7K74_RS20635	COG2207	Transcriptional regulator
H7K74_RS20650	COG0242	peptide deformylase activity
H7K74_RS20670	COG2814	Major facilitator Superfamily
H7K74_RS20685	COG1764	response to oxidative stress
H7K74_RS20690	COG1846	Transcriptional regulator
H7K74_RS20710	COG1301	dicarboxylic acid transport
H7K74_RS20715	COG1802	Transcriptional regulator
H7K74_RS20725	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS20730	COG0583	DNA-binding transcription factor activity
H7K74_RS20740	COG2801	Transposase and inactivated derivatives
H7K74_RS20740	COG3415	Transposase
H7K74_RS20785	COG0625	glutathione transferase activity
H7K74_RS20795	COG1309	transcriptional regulator
H7K74_RS20800	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7K74_RS20800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7K74_RS20805	COG1393	Belongs to the ArsC family
H7K74_RS20840	COG1392	Phosphate transport regulator
H7K74_RS20845	COG0306	phosphate transporter
H7K74_RS20870	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H7K74_RS20875	COG0318	PFAM AMP-dependent synthetase and ligase
H7K74_RS20890	COG1160	GTP binding
H7K74_RS20925	COG0300	oxidoreductase activity
H7K74_RS20930	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H7K74_RS20935	COG1286	toxin biosynthetic process
H7K74_RS20945	COG1879	ABC-type sugar transport system periplasmic component
H7K74_RS20985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7K74_RS20990	COG0305	Participates in initiation and elongation during chromosome replication
H7K74_RS21000	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H7K74_RS21020	COG0359	binds to the 23S rRNA
H7K74_RS21030	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H7K74_RS21035	COG0360	Binds together with S18 to 16S ribosomal RNA
H7K74_RS21050	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H7K74_RS21060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7K74_RS21065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7K74_RS21070	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H7K74_RS21075	COG1561	YicC-like family, N-terminal region
H7K74_RS21080	COG0194	GDP metabolic process
H7K74_RS21155	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H7K74_RS21160	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H7K74_RS21180	COG0795	lipopolysaccharide-transporting ATPase activity
H7K74_RS21185	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7K74_RS21215	COG3162	membrane
H7K74_RS21220	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7K74_RS21230	COG2176	DNA-directed DNA polymerase activity
H7K74_RS21235	COG0488	(ABC) transporter
H7K74_RS21250	COG0105	UTP biosynthetic process
H7K74_RS21255	COG0861	Integral membrane protein TerC family
H7K74_RS21260	COG0248	Ppx GppA phosphatase
H7K74_RS21265	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H7K74_RS21275	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H7K74_RS21280	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H7K74_RS21285	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H7K74_RS21290	COG1278	Cold shock
H7K74_RS21325	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7K74_RS21330	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H7K74_RS21355	COG1175	transmembrane transport
H7K74_RS21365	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H7K74_RS21370	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H7K74_RS21380	COG0281	malic enzyme
H7K74_RS21380	COG0280	phosphate acetyltransferase
H7K74_RS21400	COG0386	Belongs to the glutathione peroxidase family
H7K74_RS21410	COG3045	CreA protein
H7K74_RS21445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7K74_RS21455	COG3483	tryptophan 2,3-dioxygenase activity
H7K74_RS21490	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS21495	COG2365	Tyrosine phosphatase family
H7K74_RS21515	COG0174	glutamine synthetase
H7K74_RS21565	COG2207	Transcriptional regulator
H7K74_RS21585	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS21590	COG0488	(ABC) transporter
H7K74_RS21615	COG0657	acetylesterase activity
H7K74_RS21625	COG0840	transmembrane signaling receptor activity
H7K74_RS21650	COG2207	Transcriptional regulator
H7K74_RS21700	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H7K74_RS21725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K74_RS21730	COG1309	transcriptional regulator
H7K74_RS21740	COG0850	regulation of cytokinetic process
H7K74_RS21745	COG2894	cell division
H7K74_RS21750	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H7K74_RS21770	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS21785	COG1376	ErfK ybiS ycfS ynhG family protein
H7K74_RS21825	COG1309	transcriptional regulator
H7K74_RS21850	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H7K74_RS21890	COG2824	Alkylphosphonate utilization operon protein PhnA
H7K74_RS21980	COG1335	isochorismatase
H7K74_RS22015	COG1574	metal-dependent hydrolase with the TIM-barrel fold
H7K74_RS22055	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7K74_RS22095	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7K74_RS22100	COG0697	spore germination
H7K74_RS22105	COG4191	Histidine kinase
H7K74_RS22105	COG0784	Response regulator, receiver
H7K74_RS22135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7K74_RS22145	COG0657	acetylesterase activity
H7K74_RS22155	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H7K74_RS22160	COG0745	RESPONSE REGULATOR receiver
H7K74_RS22165	COG0784	Response regulator, receiver
H7K74_RS22170	COG5002	protein histidine kinase activity
H7K74_RS22175	COG0439	Biotin carboxylase
H7K74_RS22180	COG0511	ligase activity, forming carbon-carbon bonds
H7K74_RS22185	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H7K74_RS22205	COG0436	Aminotransferase
H7K74_RS22210	COG1268	BioY protein
H7K74_RS22215	COG1301	dicarboxylic acid transport
H7K74_RS22235	COG2271	Major facilitator Superfamily
H7K74_RS22250	COG1530	ribonuclease E activity
H7K74_RS22250	COG1530	ribonuclease E activity
H7K74_RS22255	COG0860	N-Acetylmuramoyl-L-alanine amidase
H7K74_RS22260	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H7K74_RS22270	COG2084	Dehydrogenase
H7K74_RS22280	COG0697	spore germination
H7K74_RS22305	COG0438	transferase activity, transferring glycosyl groups
H7K74_RS22325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K74_RS22330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K74_RS22345	COG0739	heme binding
H7K74_RS22350	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H7K74_RS22375	COG2259	Doxx family
H7K74_RS22385	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H7K74_RS22390	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H7K74_RS22395	COG0625	glutathione transferase activity
H7K74_RS22410	COG2945	thiolester hydrolase activity
H7K74_RS22425	COG1104	cysteine desulfurase activity
H7K74_RS22430	COG0719	Fe-S assembly protein
H7K74_RS22435	COG0396	ATPase activity
H7K74_RS22440	COG0719	Fe-S assembly protein
H7K74_RS22445	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H7K74_RS22450	COG2151	metal-sulfur cluster biosynthetic enzyme
H7K74_RS22455	COG0316	Belongs to the HesB IscA family
H7K74_RS22465	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7K74_RS22475	COG0513	Belongs to the DEAD box helicase family
H7K74_RS22505	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS22520	COG0187	DNA topoisomerase II activity
H7K74_RS22525	COG0586	Pfam SNARE associated Golgi protein
H7K74_RS22550	COG3243	poly(R)-hydroxyalkanoic acid synthase
H7K74_RS22560	COG0436	Aminotransferase
H7K74_RS22570	COG1494	fructose-1,6-bisphosphatase
H7K74_RS22590	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H7K74_RS22595	COG1802	Transcriptional regulator
H7K74_RS22605	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7K74_RS22625	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H7K74_RS22635	COG0840	transmembrane signaling receptor activity
H7K74_RS22640	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H7K74_RS22665	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7K74_RS22685	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H7K74_RS22690	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H7K74_RS22705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7K74_RS22820	COG3750	Belongs to the UPF0335 family
H7K74_RS22900	COG0616	signal peptide processing
H7K74_RS23080	COG0625	glutathione transferase activity
H7K74_RS23100	COG2267	carboxylic ester hydrolase activity
H7K74_RS23120	COG0776	regulation of translation
H7K74_RS23160	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H7K74_RS23205	COG1522	sequence-specific DNA binding
H7K74_RS23225	COG1960	acyl-CoA dehydrogenase activity
H7K74_RS23230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7K74_RS23235	COG4770	biotin carboxylase activity
H7K74_RS23245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7K74_RS23250	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H7K74_RS23255	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H7K74_RS23255	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H7K74_RS23280	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H7K74_RS23345	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H7K74_RS23400	COG3750	Belongs to the UPF0335 family
H7K74_RS23490	COG0616	signal peptide processing
H7K74_RS23635	COG1793	dna ligase
H7K74_RS23645	COG2373	Large extracellular alpha-helical protein
H7K74_RS23650	COG4953	penicillin-binding protein 1C
H7K74_RS23660	COG0671	phosphoesterase, PA-phosphatase related
H7K74_RS23665	COG0463	Glycosyl transferase, family 2
H7K74_RS23680	COG1283	sodium-dependent phosphate transmembrane transporter activity
H7K74_RS23685	COG0626	cystathionine gamma-synthase activity
H7K74_RS23690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K74_RS23695	COG4597	amino acid ABC transporter
H7K74_RS23700	COG0765	amino acid transport
H7K74_RS23705	COG1126	abc transporter atp-binding protein
H7K74_RS23740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K74_RS23780	COG1126	abc transporter atp-binding protein
H7K74_RS23795	COG0251	oxidation-reduction process
H7K74_RS23820	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7K74_RS23835	COG0525	valine-tRNA ligase activity
H7K74_RS23840	COG2094	Belongs to the DNA glycosylase MPG family
H7K74_RS23845	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H7K74_RS23850	COG2867	negative regulation of translational initiation
H7K74_RS23855	COG2863	cytochrome
H7K74_RS23860	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7K74_RS23890	COG1058	Belongs to the CinA family
H7K74_RS23890	COG1546	Belongs to the CinA family
H7K74_RS23895	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H7K74_RS23895	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H7K74_RS23915	COG5000	phosphorelay sensor kinase activity
H7K74_RS23920	COG2204	response regulator
H7K74_RS23925	COG1923	regulation of RNA biosynthetic process
H7K74_RS23930	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H7K74_RS23935	COG0454	-acetyltransferase
H7K74_RS23940	COG3956	TIGRFAM MazG family protein
H7K74_RS23945	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H7K74_RS23970	COG0471	metal ion transport
H7K74_RS23975	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H7K74_RS23980	COG2011	ABC-type metal ion transport system permease component
H7K74_RS23990	COG4774	siderophore transport
H7K74_RS24030	COG0006	proline dipeptidase activity
H7K74_RS24035	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H7K74_RS24040	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H7K74_RS24045	COG0318	PFAM AMP-dependent synthetase and ligase
H7K74_RS24050	COG0321	lipoyl(octanoyl) transferase activity
H7K74_RS24050	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H7K74_RS24055	COG0084	hydrolase, TatD family'
H7K74_RS24070	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H7K74_RS24075	COG1686	Belongs to the peptidase S11 family
H7K74_RS24080	COG2267	carboxylic ester hydrolase activity
H7K74_RS24085	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H7K74_RS24130	COG4974	Belongs to the 'phage' integrase family
H7K74_RS24240	COG0129	dihydroxy-acid dehydratase activity
H7K74_RS24260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K74_RS24265	COG0601	transmembrane transport
H7K74_RS24275	COG0444	Belongs to the ABC transporter superfamily
H7K74_RS24295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7K74_RS24295	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H7K74_RS24305	COG1335	isochorismatase
H7K74_RS24340	COG1175	transmembrane transport
H7K74_RS24395	COG0473	3-isopropylmalate dehydrogenase activity
H7K74_RS24395	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7K74_RS24405	COG1984	allophanate hydrolase subunit 2
H7K74_RS24410	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H7K74_RS24420	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7K74_RS24425	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7K74_RS24430	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7K74_RS24435	COG3707	response regulator
H7K74_RS24445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7K74_RS24455	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7K74_RS24460	COG0789	Transcriptional regulator
H7K74_RS24480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7K74_RS24490	COG1253	flavin adenine dinucleotide binding
H7K74_RS24495	COG1183	phosphatidylcholine synthase activity
H7K74_RS24500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7K74_RS24505	COG0679	Auxin Efflux Carrier
H7K74_RS24545	COG1278	Cold shock
H7K74_RS24555	COG0667	Aldo Keto reductase
H7K74_RS24575	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H7K74_RS24590	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H7K74_RS24605	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H7K74_RS24615	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H7K74_RS24765	COG0459	protein refolding
H7K74_RS24775	COG0071	Belongs to the small heat shock protein (HSP20) family
H7K74_RS24780	COG0517	IMP dehydrogenase activity
H7K74_RS24780	COG0617	tRNA 3'-terminal CCA addition
H7K74_RS24780	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H7K74_RS24785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7K74_RS24795	COG0517	IMP dehydrogenase activity
H7K74_RS24795	COG0516	GMP reductase activity
H7K74_RS24845	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7K74_RS24855	COG0484	heat shock protein binding
H7K74_RS24865	COG0574	Belongs to the PEP-utilizing enzyme family
H7K74_RS24865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7K74_RS24875	COG2723	6-phospho-beta-galactosidase activity
H7K74_RS24925	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H7K74_RS24945	COG0628	permease
H7K74_RS24970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7K74_RS24995	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H7K74_RS25015	COG0697	spore germination
H7K74_RS25065	COG1309	transcriptional regulator
H7K74_RS25075	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H7K74_RS25085	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H7K74_RS25105	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H7K74_RS25115	COG3158	transport of potassium into the cell
H7K74_RS25130	COG0629	single-stranded DNA binding
H7K74_RS25150	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H7K74_RS25165	COG0546	phosphoglycolate phosphatase activity
H7K74_RS25220	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H7K74_RS25275	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
H7K74_RS25285	COG2340	Cysteine-rich secretory protein family
H7K74_RS25300	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H7K74_RS25320	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7K74_RS25325	COG1862	Preprotein translocase
H7K74_RS25335	COG3119	arylsulfatase activity
H7K74_RS25350	COG3119	arylsulfatase activity
H7K74_RS25355	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7K74_RS25360	COG4942	peptidase
H7K74_RS25365	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7K74_RS25375	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H7K74_RS25385	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H7K74_RS25390	COG0805	protein transport
H7K74_RS25395	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7K74_RS25400	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7K74_RS25405	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H7K74_RS25410	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H7K74_RS25415	COG1472	Belongs to the glycosyl hydrolase 3 family
H7K74_RS25425	COG0018	arginyl-trna synthetase
H7K74_RS25430	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H7K74_RS25440	COG2198	Histidine kinase
H7K74_RS25440	COG5002	protein histidine kinase activity
H7K74_RS25440	COG0784	Response regulator, receiver
H7K74_RS25445	COG0708	Exodeoxyribonuclease III
H7K74_RS25450	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
H7K74_RS25455	COG0129	dihydroxy-acid dehydratase activity
H7K74_RS25465	COG4206	TonB-dependent receptor
H7K74_RS25515	COG4191	Histidine kinase
H7K74_RS25520	COG4566	intracellular signal transduction
H7K74_RS25525	COG4566	intracellular signal transduction
H7K74_RS25535	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7K74_RS25540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7K74_RS25550	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7K74_RS25565	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7K74_RS25565	COG0022	dehydrogenase e1 component
H7K74_RS25570	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H7K74_RS25575	COG1012	belongs to the aldehyde dehydrogenase family
H7K74_RS25590	COG0431	NADPH-dependent FMN reductase
H7K74_RS25600	COG4977	sequence-specific DNA binding
H7K74_RS25600	COG1917	Cupin 2, conserved barrel domain protein
H7K74_RS25625	COG0148	phosphopyruvate hydratase activity
H7K74_RS25635	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H7K74_RS25645	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
H7K74_RS25645	COG2066	Belongs to the glutaminase family
H7K74_RS25655	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H7K74_RS25665	COG0745	RESPONSE REGULATOR receiver
H7K74_RS25670	COG2205	protein histidine kinase activity
H7K74_RS25675	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H7K74_RS25680	COG0504	CTP synthase activity
H7K74_RS25690	COG0149	triose-phosphate isomerase activity
H7K74_RS25695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7K74_RS25700	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H7K74_RS25705	COG0134	indole-3-glycerol-phosphate synthase activity
H7K74_RS25710	COG0315	cyclic pyranopterin monophosphate synthase activity
H7K74_RS25720	COG5001	Diguanylate cyclase
H7K74_RS25720	COG3300	MHYT domain
H7K74_RS25775	COG0793	Belongs to the peptidase S41A family
H7K74_RS25780	COG1304	FMN binding
H7K74_RS25785	COG1011	Hydrolase
H7K74_RS25800	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H7K74_RS25830	COG0477	Major facilitator Superfamily
H7K74_RS25855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7K74_RS25860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7K74_RS25865	COG0372	Belongs to the citrate synthase family
H7K74_RS25885	COG1175	transmembrane transport
H7K74_RS25890	COG0395	ABC-type sugar transport system, permease component
H7K74_RS25900	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS25920	COG3069	C4-dicarboxylate transmembrane transporter activity
H7K74_RS25945	COG1802	Transcriptional regulator
H7K74_RS25950	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7K74_RS25960	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7K74_RS25970	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7K74_RS25975	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7K74_RS25980	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7K74_RS25985	COG0750	zinc metalloprotease
H7K74_RS25990	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H7K74_RS26000	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H7K74_RS26005	COG0233	cytoplasmic translational termination
H7K74_RS26010	COG0528	UMP kinase activity
H7K74_RS26015	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H7K74_RS26020	COG0052	Belongs to the universal ribosomal protein uS2 family
H7K74_RS26040	COG0288	reversible hydration of carbon dioxide
H7K74_RS26070	COG2814	Major facilitator Superfamily
H7K74_RS26075	COG0024	Methionine aminopeptidase
H7K74_RS26095	COG1136	(ABC) transporter
H7K74_RS26105	COG0442	prolyl-tRNA aminoacylation
H7K74_RS26145	COG1129	ABC transporter
H7K74_RS26150	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7K74_RS26160	COG0251	oxidation-reduction process
H7K74_RS26165	COG0583	DNA-binding transcription factor activity
H7K74_RS26185	COG4608	Belongs to the ABC transporter superfamily
H7K74_RS26190	COG0444	Belongs to the ABC transporter superfamily
H7K74_RS26195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K74_RS26230	COG0346	lactoylglutathione lyase activity
H7K74_RS26245	COG1007	ATP synthesis coupled electron transport
H7K74_RS26260	COG0713	ATP synthesis coupled electron transport
H7K74_RS26270	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7K74_RS26275	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H7K74_RS26285	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H7K74_RS26295	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H7K74_RS26305	COG0649	NAD binding
H7K74_RS26315	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7K74_RS26330	COG4774	siderophore transport
H7K74_RS26345	COG2814	Major facilitator Superfamily
H7K74_RS26355	COG0653	protein targeting
H7K74_RS26370	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7K74_RS26380	COG1595	DNA-templated transcription, initiation
H7K74_RS26405	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K74_RS26430	COG1230	cation diffusion facilitator family transporter
H7K74_RS26440	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H7K74_RS26440	COG2755	lipolytic protein G-D-S-L family
H7K74_RS26455	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H7K74_RS26460	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H7K74_RS26465	COG0740	serine-type endopeptidase activity
H7K74_RS26470	COG0544	peptidyl-prolyl cis-trans isomerase activity
H7K74_RS26495	COG0347	Belongs to the P(II) protein family
H7K74_RS26500	COG0174	glutamine synthetase
H7K74_RS26505	COG0252	asparaginase activity
H7K74_RS26510	COG0330	HflC and HflK could
H7K74_RS26530	COG3038	cytochrome b561
H7K74_RS26540	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H7K74_RS26565	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H7K74_RS26570	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H7K74_RS26580	COG1024	Enoyl-CoA hydratase
H7K74_RS26600	COG1612	heme a metabolic process
H7K74_RS26625	COG0438	transferase activity, transferring glycosyl groups
H7K74_RS26640	COG1846	Transcriptional regulator
H7K74_RS26645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7K74_RS26650	COG3268	Saccharopine dehydrogenase
H7K74_RS26710	COG0657	acetylesterase activity
H7K74_RS26720	COG0135	phosphoribosylanthranilate isomerase activity
H7K74_RS26780	COG0776	regulation of translation
H7K74_RS26785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7K74_RS26790	COG0416	fatty acid biosynthetic process
H7K74_RS26815	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H7K74_RS26820	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H7K74_RS26825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7K74_RS26830	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H7K74_RS26840	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7K74_RS26840	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7K74_RS26845	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H7K74_RS26850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H7K74_RS26875	COG0113	porphobilinogen synthase activity
H7K74_RS26885	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H7K74_RS26910	COG1914	H( )-stimulated, divalent metal cation uptake system
H7K74_RS26920	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H7K74_RS26940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7K74_RS26955	COG2059	Chromate
H7K74_RS26975	COG0747	negative chemotaxis
H7K74_RS26980	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H7K74_RS26990	COG1381	Involved in DNA repair and RecF pathway recombination
H7K74_RS27000	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H7K74_RS27005	COG0571	ribonuclease III activity
H7K74_RS27010	COG0681	Belongs to the peptidase S26 family
H7K74_RS27015	COG0736	holo-[acyl-carrier-protein] synthase activity
H7K74_RS27020	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H7K74_RS27030	COG1758	RNA polymerase activity
H7K74_RS27050	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H7K74_RS27055	COG1970	mechanosensitive ion channel activity
H7K74_RS27060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7K74_RS27065	COG0741	lytic transglycosylase activity
H7K74_RS27070	COG3119	arylsulfatase activity
H7K74_RS27075	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7K74_RS27100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K74_RS27125	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H7K74_RS27135	COG0154	amidase activity
H7K74_RS27145	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H7K74_RS27150	COG2070	2-Nitropropane dioxygenase
H7K74_RS27160	COG0583	DNA-binding transcription factor activity
H7K74_RS27170	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H7K74_RS27180	COG2801	Transposase and inactivated derivatives
H7K74_RS27180	COG3415	Transposase
H7K74_RS27190	COG1960	acyl-CoA dehydrogenase activity
H7K74_RS27200	COG0540	Belongs to the ATCase OTCase family
H7K74_RS27210	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H7K74_RS27220	COG0154	amidase activity
H7K74_RS27225	COG0758	DNA mediated transformation
H7K74_RS27230	COG1733	regulation of RNA biosynthetic process
H7K74_RS27235	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7K74_RS27245	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS27255	COG0655	NAD(P)H dehydrogenase (quinone) activity
H7K74_RS27265	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H7K74_RS27270	COG0557	exoribonuclease II activity
H7K74_RS27295	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H7K74_RS27325	COG0784	Response regulator, receiver
H7K74_RS27335	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7K74_RS27350	COG0494	nUDIX hydrolase
H7K74_RS27380	COG0537	adenosine 5'-monophosphoramidase activity
H7K74_RS27385	COG1720	tRNA m6t6A37 methyltransferase activity
H7K74_RS27430	COG1482	cell wall glycoprotein biosynthetic process
H7K74_RS27465	COG0667	Aldo Keto reductase
H7K74_RS27475	COG2814	Major facilitator Superfamily
H7K74_RS27505	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H7K74_RS27520	COG1686	Belongs to the peptidase S11 family
H7K74_RS27530	COG1275	C4-dicarboxylate transporter malic acid transport protein
H7K74_RS27545	COG1192	Involved in chromosome partitioning
H7K74_RS27550	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H7K74_RS27595	COG0656	L-ascorbic acid biosynthetic process
H7K74_RS27605	COG2239	Acts as a magnesium transporter
H7K74_RS27645	COG0321	lipoyl(octanoyl) transferase activity
H7K74_RS27650	COG0305	Participates in initiation and elongation during chromosome replication
H7K74_RS27665	COG1090	epimerase
H7K74_RS27685	COG1254	Belongs to the acylphosphatase family
H7K74_RS27690	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H7K74_RS27695	COG4770	biotin carboxylase activity
H7K74_RS27730	COG2271	Major facilitator Superfamily
H7K74_RS27740	COG4948	Mandelate Racemase Muconate Lactonizing
H7K74_RS27745	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS27750	COG1063	alcohol dehydrogenase
H7K74_RS27765	COG2197	response regulator
H7K74_RS27775	COG1414	Transcriptional regulator
H7K74_RS27780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7K74_RS27785	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7K74_RS27830	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS27870	COG4566	intracellular signal transduction
H7K74_RS27875	COG1566	PFAM secretion protein HlyD family protein
H7K74_RS27880	COG1136	(ABC) transporter
H7K74_RS27880	COG0577	efflux transmembrane transporter activity
H7K74_RS27885	COG0577	efflux transmembrane transporter activity
H7K74_RS27885	COG1136	(ABC) transporter
H7K74_RS27905	COG0450	alkyl hydroperoxide reductase
H7K74_RS27915	COG0415	Belongs to the DNA photolyase family
H7K74_RS28015	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS28020	COG2030	dehydratase
H7K74_RS28050	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7K74_RS28050	COG2010	Cytochrome c
H7K74_RS28055	COG2860	membrane
H7K74_RS28115	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7K74_RS28120	COG3360	Dodecin
H7K74_RS28150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7K74_RS28175	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H7K74_RS28200	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H7K74_RS28215	COG1733	regulation of RNA biosynthetic process
H7K74_RS28230	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS28235	COG3181	Tripartite tricarboxylate transporter family receptor
H7K74_RS28240	COG0203	ribosomal protein L17
H7K74_RS28245	COG0202	RNA polymerase activity
H7K74_RS28250	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H7K74_RS28255	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H7K74_RS28260	COG0563	adenylate kinase activity
H7K74_RS28270	COG0200	Binds to the 23S rRNA
H7K74_RS28275	COG1841	ribosomal large subunit assembly
H7K74_RS28280	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H7K74_RS28285	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H7K74_RS28290	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H7K74_RS28295	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H7K74_RS28300	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H7K74_RS28305	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H7K74_RS28310	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H7K74_RS28315	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H7K74_RS28320	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H7K74_RS28325	COG0255	Belongs to the universal ribosomal protein uL29 family
H7K74_RS28330	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H7K74_RS28335	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H7K74_RS28340	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H7K74_RS28345	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H7K74_RS28350	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H7K74_RS28355	COG0089	rRNA binding
H7K74_RS28360	COG0088	Forms part of the polypeptide exit tunnel
H7K74_RS28365	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H7K74_RS28370	COG0051	transcription antitermination factor activity, RNA binding
H7K74_RS28375	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7K74_RS28380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H7K74_RS28385	COG0049	tRNA binding
H7K74_RS28390	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H7K74_RS28400	COG1132	(ABC) transporter
H7K74_RS28405	COG1231	oxidoreductase activity
H7K74_RS28410	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H7K74_RS28415	COG0085	RNA polymerase activity
H7K74_RS28420	COG0222	ribosome binding
H7K74_RS28425	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H7K74_RS28430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7K74_RS28435	COG0081	regulation of translation
H7K74_RS28440	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H7K74_RS28445	COG0250	Participates in transcription elongation, termination and antitermination
H7K74_RS28450	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H7K74_RS28470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7K74_RS28475	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H7K74_RS28475	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H7K74_RS28480	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7K74_RS28495	COG3959	Transketolase, thiamine diphosphate binding domain
H7K74_RS28500	COG3958	Transketolase
H7K74_RS28525	COG2226	methyltransferase
H7K74_RS28545	COG0673	inositol 2-dehydrogenase activity
H7K74_RS28580	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS28590	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS28610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7K74_RS28615	COG1280	lysine exporter protein (LysE YggA)
H7K74_RS28635	COG1960	acyl-CoA dehydrogenase activity
H7K74_RS28655	COG3246	L-lysine catabolic process to acetate
H7K74_RS28660	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7K74_RS28670	COG3246	L-lysine catabolic process to acetate
H7K74_RS28690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7K74_RS28710	COG2274	protein secretion by the type I secretion system
H7K74_RS28755	COG0437	4 iron, 4 sulfur cluster binding
H7K74_RS28825	COG0784	Response regulator, receiver
H7K74_RS28825	COG4191	Histidine kinase
H7K74_RS28845	COG3795	YCII-related domain
H7K74_RS28855	COG0210	DNA helicase
H7K74_RS28860	COG0402	S-adenosylhomocysteine deaminase activity
H7K74_RS28870	COG0477	Major facilitator Superfamily
H7K74_RS28890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7K74_RS28995	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H7K74_RS29020	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H7K74_RS29025	COG0302	gtp cyclohydrolase
H7K74_RS29040	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H7K74_RS29060	COG0477	Major facilitator Superfamily
H7K74_RS29100	COG2814	Major facilitator Superfamily
H7K74_RS29105	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H7K74_RS29110	COG5295	Hep Hag repeat protein
H7K74_RS29130	COG5001	Diguanylate cyclase
H7K74_RS29140	COG0604	alcohol dehydrogenase
H7K74_RS29140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7K74_RS29140	COG4221	oxidoreductase activity
H7K74_RS29140	COG3321	synthase
H7K74_RS29150	COG0667	Aldo Keto reductase
H7K74_RS29165	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7K74_RS29170	COG0517	IMP dehydrogenase activity
H7K74_RS29250	COG1063	alcohol dehydrogenase
H7K74_RS29270	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H7K74_RS29285	COG3842	ATPase activity
H7K74_RS29295	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7K74_RS29300	COG3833	ABC-type maltose transport systems, permease component
H7K74_RS29365	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7K74_RS29380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7K74_RS29400	COG2814	Major facilitator Superfamily
H7K74_RS29410	COG0747	negative chemotaxis
H7K74_RS29420	COG0601	transmembrane transport
H7K74_RS29425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K74_RS29430	COG4172	Belongs to the ABC transporter superfamily
H7K74_RS29440	COG1473	amidohydrolase
H7K74_RS29445	COG0154	amidase activity
H7K74_RS29450	COG1024	Enoyl-CoA hydratase
H7K74_RS29455	COG3321	synthase
H7K74_RS29455	COG0604	alcohol dehydrogenase
H7K74_RS29465	COG0625	glutathione transferase activity
H7K74_RS29480	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H7K74_RS29485	COG1058	Belongs to the CinA family
H7K74_RS29485	COG1546	Belongs to the CinA family
H7K74_RS29490	COG2308	Evidence 4 Homologs of previously reported genes of
H7K74_RS29520	COG4221	oxidoreductase activity
H7K74_RS29535	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7K74_RS29550	COG5425	PFAM Usg family protein
H7K74_RS29555	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H7K74_RS29560	COG0459	protein refolding
H7K74_RS29570	COG0681	Belongs to the peptidase S26 family
H7K74_RS29595	COG1335	isochorismatase
H7K74_RS29660	COG0384	phenazine biosynthesis protein PhzF
H7K74_RS29670	COG2814	Major facilitator Superfamily
H7K74_RS29675	COG2188	Transcriptional regulator
H7K74_RS29690	COG0842	Transport permease protein
H7K74_RS29695	COG1131	(ABC) transporter
H7K74_RS29705	COG1309	transcriptional regulator
H7K74_RS29710	COG0640	Transcriptional regulator
H7K74_RS29750	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H7K74_RS29750	COG3608	succinylglutamate desuccinylase aspartoacylase
H7K74_RS29785	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H7K74_RS29790	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7K74_RS29795	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7K74_RS29835	COG2204	response regulator
H7K74_RS29840	COG4191	Histidine kinase
H7K74_RS29840	COG0784	Response regulator, receiver
H7K74_RS29875	COG0515	serine threonine protein kinase
H7K74_RS29875	COG2815	serine threonine protein kinase
H7K74_RS29915	COG1309	transcriptional regulator
H7K74_RS29920	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H7K74_RS29925	COG1473	amidohydrolase
H7K74_RS29955	COG0318	PFAM AMP-dependent synthetase and ligase
H7K74_RS29960	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7K74_RS30000	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H7K74_RS30020	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H7K74_RS30025	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H7K74_RS30030	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7K74_RS30035	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
H7K74_RS30065	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H7K74_RS30085	COG0047	phosphoribosylformylglycinamidine synthase activity
H7K74_RS30090	COG0598	Magnesium transport protein CorA
H7K74_RS30095	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H7K74_RS30100	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H7K74_RS30110	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
H7K74_RS30115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7K74_RS30115	COG1116	anion transmembrane transporter activity
H7K74_RS30120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K74_RS30125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7K74_RS30150	COG1309	transcriptional regulator
H7K74_RS30160	COG2020	methyltransferase activity
H7K74_RS30165	COG0604	alcohol dehydrogenase
H7K74_RS30185	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H7K74_RS30190	COG0538	isocitrate dehydrogenase activity
H7K74_RS30200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7K74_RS30205	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H7K74_RS30210	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H7K74_RS30215	COG0509	glycine decarboxylation via glycine cleavage system
H7K74_RS30220	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7K74_RS30220	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7K74_RS30230	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H7K74_RS30330	COG0640	Transcriptional regulator
H7K74_RS30385	COG1879	ABC-type sugar transport system periplasmic component
H7K74_RS30390	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7K74_RS30400	COG1070	Carbohydrate kinase
H7K74_RS30445	COG2917	probably involved in intracellular septation
H7K74_RS30460	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H7K74_RS30460	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H7K74_RS30495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K74_RS30530	COG1684	flagellar biosynthetic protein fliR
H7K74_RS30535	COG1987	bacterial-type flagellum assembly
H7K74_RS30540	COG1677	Flagellar hook-basal body complex protein FliE
H7K74_RS30545	COG1558	bacterial-type flagellum-dependent cell motility
H7K74_RS30560	COG1338	Plays a role in the flagellum-specific transport system
H7K74_RS30610	COG4786	Flagellar basal body rod
H7K74_RS30615	COG4786	Flagellar basal body rod
H7K74_RS30625	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H7K74_RS30630	COG3971	2-oxopent-4-enoate hydratase activity
H7K74_RS30640	COG1733	regulation of RNA biosynthetic process
H7K74_RS30670	COG1566	PFAM secretion protein HlyD family protein
H7K74_RS30690	COG3119	arylsulfatase activity
H7K74_RS30695	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7K74_RS30735	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H7K74_RS30770	COG0438	transferase activity, transferring glycosyl groups
H7K74_RS30785	COG0071	Belongs to the small heat shock protein (HSP20) family
H7K74_RS30790	COG0071	Belongs to the small heat shock protein (HSP20) family
H7K74_RS30795	COG0071	Belongs to the small heat shock protein (HSP20) family
H7K74_RS30815	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H7K74_RS30820	COG0459	protein refolding
H7K74_RS30830	COG0071	Belongs to the small heat shock protein (HSP20) family
H7K74_RS30835	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7K74_RS30840	COG0071	Belongs to the small heat shock protein (HSP20) family
H7K74_RS30845	COG0071	Belongs to the small heat shock protein (HSP20) family
H7K74_RS30850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7K74_RS30885	COG2910	NAD(P)H-binding
H7K74_RS30890	COG1733	regulation of RNA biosynthetic process
H7K74_RS30900	COG1706	bacterial-type flagellum-dependent cell motility
H7K74_RS30920	COG5442	Flagellar protein FlaF
H7K74_RS30925	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7K74_RS30930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7K74_RS30935	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7K74_RS30940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7K74_RS30945	COG5443	negative regulation of bacterial-type flagellum assembly
H7K74_RS30950	COG0076	glutamate decarboxylase activity
H7K74_RS30975	COG1256	bacterial-type flagellum assembly
H7K74_RS30980	COG1749	Flagellar hook protein flgE
H7K74_RS30985	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7K74_RS30990	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H7K74_RS30990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K74_RS31010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7K74_RS31030	COG3300	MHYT domain
H7K74_RS31030	COG5001	Diguanylate cyclase
H7K74_RS31035	COG0477	Major facilitator Superfamily
H7K74_RS31040	COG3685	Protein conserved in bacteria
H7K74_RS31055	COG3415	Transposase
H7K74_RS31055	COG2801	Transposase and inactivated derivatives
H7K74_RS31060	COG2271	Major facilitator Superfamily
H7K74_RS31065	COG0583	DNA-binding transcription factor activity
H7K74_RS31070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7K74_RS31080	COG1012	belongs to the aldehyde dehydrogenase family
H7K74_RS31085	COG2721	sulfolactate sulfo-lyase activity
H7K74_RS31100	COG0745	RESPONSE REGULATOR receiver
H7K74_RS31105	COG2205	protein histidine kinase activity
H7K74_RS31130	COG0492	ferredoxin-NADP+ reductase activity
H7K74_RS31140	COG0633	Ferredoxin
H7K74_RS31160	COG0784	Response regulator, receiver
H7K74_RS31160	COG2205	protein histidine kinase activity
H7K74_RS31175	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7K74_RS31175	COG3218	ABC-type transport auxiliary lipoprotein component
H7K74_RS31180	COG1127	ABC transporter
H7K74_RS31185	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H7K74_RS31190	COG4948	Mandelate Racemase Muconate Lactonizing
H7K74_RS31195	COG2814	Major facilitator Superfamily
H7K74_RS31215	COG4154	Belongs to the RbsD FucU family
H7K74_RS31240	COG0351	phosphomethylpyrimidine kinase
H7K74_RS31245	COG4191	Histidine kinase
H7K74_RS31245	COG0784	Response regulator, receiver
H7K74_RS31255	COG2010	Cytochrome c
H7K74_RS31275	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H7K74_RS31280	COG3909	cytochrome
H7K74_RS31290	COG0456	acetyltransferase
H7K74_RS31310	COG0673	inositol 2-dehydrogenase activity
H7K74_RS31315	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H7K74_RS31315	COG0662	Cupin 2, conserved barrel domain protein
H7K74_RS31330	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H7K74_RS31350	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H7K74_RS31350	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H7K74_RS31360	COG0859	PFAM glycosyl transferase family 9
H7K74_RS31375	COG1132	(ABC) transporter
H7K74_RS31400	COG0583	DNA-binding transcription factor activity
H7K74_RS31405	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS31410	COG1942	4-Oxalocrotonate Tautomerase
H7K74_RS31425	COG0489	protein tyrosine kinase activity
H7K74_RS31440	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H7K74_RS31445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H7K74_RS31460	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H7K74_RS31530	COG0318	PFAM AMP-dependent synthetase and ligase
H7K74_RS31535	COG0559	Belongs to the binding-protein-dependent transport system permease family
H7K74_RS31555	COG2942	2-epimerase
H7K74_RS31570	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H7K74_RS31575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7K74_RS31605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7K74_RS31625	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H7K74_RS31635	COG1215	transferase activity, transferring glycosyl groups
H7K74_RS31645	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H7K74_RS31650	COG0438	transferase activity, transferring glycosyl groups
H7K74_RS31650	COG1216	Glycosyl transferase, family 2
H7K74_RS31670	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7K74_RS31675	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H7K74_RS31705	COG0438	transferase activity, transferring glycosyl groups
H7K74_RS31710	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
H7K74_RS31720	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7K74_RS31740	COG3181	Tripartite tricarboxylate transporter family receptor
H7K74_RS31750	COG1024	Enoyl-CoA hydratase
H7K74_RS31755	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H7K74_RS31760	COG2271	Major facilitator Superfamily
H7K74_RS31765	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H7K74_RS31770	COG1802	Transcriptional regulator
H7K74_RS31775	COG0277	FAD linked oxidase domain protein
H7K74_RS31775	COG0247	lactate metabolic process
H7K74_RS31840	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H7K74_RS31910	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H7K74_RS31920	COG3181	Tripartite tricarboxylate transporter family receptor
H7K74_RS31925	COG2080	2 iron, 2 sulfur cluster binding
H7K74_RS31930	COG2010	Cytochrome c
H7K74_RS31930	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7K74_RS31940	COG0517	IMP dehydrogenase activity
H7K74_RS31940	COG0516	GMP reductase activity
H7K74_RS31955	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS31970	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H7K74_RS31985	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
H7K74_RS31995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7K74_RS32000	COG2010	Cytochrome c
H7K74_RS32005	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7K74_RS32005	COG3218	ABC-type transport auxiliary lipoprotein component
H7K74_RS32010	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H7K74_RS32030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7K74_RS32030	COG1042	CoA-binding domain protein
H7K74_RS32030	COG0045	succinate-CoA ligase (ADP-forming) activity
H7K74_RS32055	COG3243	poly(R)-hydroxyalkanoic acid synthase
H7K74_RS32060	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H7K74_RS32060	COG0617	tRNA 3'-terminal CCA addition
H7K74_RS32060	COG0517	IMP dehydrogenase activity
H7K74_RS32065	COG0251	oxidation-reduction process
H7K74_RS32095	COG1024	Enoyl-CoA hydratase
H7K74_RS32100	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS32110	COG1960	acyl-CoA dehydrogenase activity
H7K74_RS32115	COG0318	PFAM AMP-dependent synthetase and ligase
H7K74_RS32125	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7K74_RS32135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K74_RS32140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K74_RS32150	COG0129	dihydroxy-acid dehydratase activity
H7K74_RS32195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7K74_RS32230	COG3547	Transposase (IS116 IS110 IS902 family)
H7K74_RS32295	COG4948	Mandelate Racemase Muconate Lactonizing
H7K74_RS32305	COG3258	Cytochrome c
H7K74_RS32315	COG0010	Belongs to the arginase family
H7K74_RS32325	COG3300	MHYT domain
H7K74_RS32325	COG5001	Diguanylate cyclase
H7K74_RS32350	COG2010	Cytochrome c
H7K74_RS32425	COG2252	PERMEase
H7K74_RS32430	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H7K74_RS32440	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7K74_RS32445	COG1301	dicarboxylic acid transport
H7K74_RS32465	COG1079	Belongs to the binding-protein-dependent transport system permease family
H7K74_RS32470	COG1079	Belongs to the binding-protein-dependent transport system permease family
H7K74_RS32480	COG3845	ABC transporter
H7K74_RS32495	COG3845	ABC transporter
H7K74_RS32500	COG4603	Belongs to the binding-protein-dependent transport system permease family
H7K74_RS32505	COG1079	Belongs to the binding-protein-dependent transport system permease family
H7K74_RS32525	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7K74_RS32525	COG2080	2 iron, 2 sulfur cluster binding
H7K74_RS32530	COG2233	PERMEase
H7K74_RS32575	COG0235	Class ii aldolase
H7K74_RS32580	COG2095	MarC family integral membrane protein
H7K74_RS32595	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H7K74_RS32605	COG0776	regulation of translation
H7K74_RS32610	COG0183	Belongs to the thiolase family
H7K74_RS32615	COG2723	6-phospho-beta-galactosidase activity
H7K74_RS32655	COG4771	TonB-dependent receptor
H7K74_RS32665	COG2197	response regulator
H7K74_RS32670	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H7K74_RS32690	COG1131	(ABC) transporter
H7K74_RS32825	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H7K74_RS32830	COG3791	Glutathione-dependent formaldehyde-activating
H7K74_RS32850	COG0723	plastoquinol--plastocyanin reductase activity
H7K74_RS32860	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7K74_RS32865	COG0277	FAD linked oxidase domain protein
H7K74_RS32870	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7K74_RS32905	COG5001	Diguanylate cyclase
H7K74_RS32905	COG3300	MHYT domain
H7K74_RS32950	COG1309	transcriptional regulator
H7K74_RS32955	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H7K74_RS32960	COG2986	histidine ammonia-lyase
H7K74_RS32965	COG1228	amidohydrolase
H7K74_RS32970	COG1228	amidohydrolase
H7K74_RS32985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K74_RS32990	COG1116	anion transmembrane transporter activity
H7K74_RS33000	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7K74_RS33010	COG4977	sequence-specific DNA binding
H7K74_RS33010	COG1917	Cupin 2, conserved barrel domain protein
H7K74_RS33015	COG2223	nitrite transmembrane transporter activity
H7K74_RS33030	COG0656	L-ascorbic acid biosynthetic process
H7K74_RS33040	COG1566	PFAM secretion protein HlyD family protein
H7K74_RS33050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7K74_RS33060	COG1764	response to oxidative stress
H7K74_RS33070	COG0596	Alpha beta hydrolase
H7K74_RS33105	COG2267	carboxylic ester hydrolase activity
H7K74_RS33110	COG2169	Transcriptional regulator
H7K74_RS33120	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H7K74_RS33140	COG1802	Transcriptional regulator
H7K74_RS33155	COG2124	cytochrome p450
H7K74_RS33165	COG2873	o-acetylhomoserine
H7K74_RS33170	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H7K74_RS33180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7K74_RS33185	COG0318	PFAM AMP-dependent synthetase and ligase
H7K74_RS33200	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS33210	COG2197	response regulator
H7K74_RS33215	COG2197	response regulator
H7K74_RS33280	COG0297	glycogen (starch) synthase activity
H7K74_RS33325	COG0367	asparagine synthase
H7K74_RS33335	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7K74_RS33380	COG2963	transposase activity
H7K74_RS33385	COG3436	PFAM IS66 Orf2 family protein
H7K74_RS33390	COG4372	Transposase
H7K74_RS33400	COG3436	PFAM IS66 Orf2 family protein
H7K74_RS33425	COG3436	PFAM IS66 Orf2 family protein
H7K74_RS33430	COG2963	transposase activity
H7K74_RS33470	COG3328	transposase activity
H7K74_RS33475	COG3328	transposase activity
H7K74_RS33480	COG4372	Transposase
H7K74_RS33485	COG4372	Transposase
H7K74_RS33495	COG2192	nodulation
H7K74_RS33525	COG1596	polysaccharide export
H7K74_RS33530	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7K74_RS33570	COG1012	belongs to the aldehyde dehydrogenase family
H7K74_RS33575	COG2084	Dehydrogenase
H7K74_RS33580	COG1129	ABC transporter
H7K74_RS33590	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7K74_RS33610	COG1522	sequence-specific DNA binding
H7K74_RS33655	COG0651	ATP synthesis coupled electron transport
H7K74_RS33670	COG0651	ATP synthesis coupled electron transport
H7K74_RS33675	COG0649	NAD binding
H7K74_RS33680	COG3260	NADH ubiquinone oxidoreductase 20
H7K74_RS33785	COG0582	viral genome integration into host DNA
H7K74_RS33810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7K74_RS33825	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7K74_RS33840	COG0559	Belongs to the binding-protein-dependent transport system permease family
H7K74_RS33865	COG0673	inositol 2-dehydrogenase activity
H7K74_RS33870	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H7K74_RS33880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7K74_RS33885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7K74_RS33890	COG1960	acyl-CoA dehydrogenase activity
H7K74_RS33895	COG1116	anion transmembrane transporter activity
H7K74_RS33910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7K74_RS33920	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H7K74_RS33925	COG0297	glycogen (starch) synthase activity
H7K74_RS33930	COG4095	Psort location CytoplasmicMembrane, score
H7K74_RS33940	COG3384	dioxygenase
H7K74_RS33960	COG2072	flavoprotein involved in K transport
H7K74_RS33980	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H7K74_RS33985	COG0281	malic enzyme
H7K74_RS33995	COG0668	transmembrane transport
H7K74_RS34010	COG2326	polyphosphate kinase activity
H7K74_RS34075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K74_RS34085	COG1125	glycine betaine transport
H7K74_RS34085	COG0517	IMP dehydrogenase activity
H7K74_RS34090	COG1174	glycine betaine transport
H7K74_RS34110	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS34120	COG5001	Diguanylate cyclase
H7K74_RS34120	COG3300	MHYT domain
H7K74_RS34125	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H7K74_RS34145	COG0440	acetolactate synthase activity
H7K74_RS34155	COG0028	Belongs to the TPP enzyme family
H7K74_RS34160	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H7K74_RS34180	COG0330	HflC and HflK could
H7K74_RS34185	COG0330	HflC and HflK could
H7K74_RS34200	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H7K74_RS34240	COG0114	fumarate hydratase activity
H7K74_RS34290	COG1309	transcriptional regulator
H7K74_RS34295	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS34325	COG1309	transcriptional regulator
H7K74_RS34375	COG2202	Pas domain
H7K74_RS34375	COG2199	diguanylate cyclase activity
H7K74_RS34375	COG2200	EAL domain
H7K74_RS34380	COG2271	Major facilitator Superfamily
H7K74_RS34385	COG3300	MHYT domain
H7K74_RS34385	COG5001	Diguanylate cyclase
H7K74_RS34395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7K74_RS34400	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H7K74_RS34405	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H7K74_RS34415	COG2259	Doxx family
H7K74_RS34420	COG0583	DNA-binding transcription factor activity
H7K74_RS34445	COG0277	FAD linked oxidase domain protein
H7K74_RS34455	COG5487	UPF0391 membrane protein
H7K74_RS34460	COG0210	DNA helicase
H7K74_RS34480	COG1088	dTDP-glucose 4,6-dehydratase activity
H7K74_RS34495	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
H7K74_RS34515	COG0071	Belongs to the small heat shock protein (HSP20) family
H7K74_RS34540	COG2267	carboxylic ester hydrolase activity
H7K74_RS34550	COG1131	(ABC) transporter
H7K74_RS34555	COG0842	Transport permease protein
H7K74_RS34575	COG0584	glycerophosphoryl diester phosphodiesterase
H7K74_RS34595	COG2264	protein methyltransferase activity
H7K74_RS34605	COG0006	proline dipeptidase activity
H7K74_RS34605	COG0006	proline dipeptidase activity
H7K74_RS34610	COG2814	Major facilitator Superfamily
H7K74_RS34615	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H7K74_RS34625	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7K74_RS34635	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H7K74_RS34640	COG0849	cell division
H7K74_RS34645	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H7K74_RS34650	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7K74_RS34655	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H7K74_RS34660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7K74_RS34665	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H7K74_RS34675	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H7K74_RS34680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H7K74_RS34685	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H7K74_RS34690	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H7K74_RS34705	COG0275	rRNA processing
H7K74_RS34710	COG3023	N-Acetylmuramoyl-L-alanine amidase
H7K74_RS34715	COG4941	Belongs to the sigma-70 factor family
H7K74_RS34720	COG3795	YCII-related domain
H7K74_RS34740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7K74_RS34760	COG5265	(ABC) transporter
H7K74_RS34775	COG1309	transcriptional regulator
H7K74_RS34815	COG0688	phosphatidylethanolamine metabolic process
H7K74_RS34840	COG1376	ErfK ybiS ycfS ynhG family protein
H7K74_RS34840	COG1388	LysM domain
H7K74_RS34845	COG3474	cytochrome
H7K74_RS34890	COG3842	ATPase activity
H7K74_RS34900	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7K74_RS34955	COG2022	thiamine diphosphate biosynthetic process
H7K74_RS34965	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H7K74_RS34985	COG0625	glutathione transferase activity
H7K74_RS35025	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS35030	COG2204	response regulator
H7K74_RS35055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7K74_RS35070	COG2193	ferroxidase activity
H7K74_RS35110	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7K74_RS35115	COG1376	ErfK ybiS ycfS ynhG family protein
H7K74_RS35125	COG2897	thiosulfate sulfurtransferase activity
H7K74_RS35130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7K74_RS35145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7K74_RS35150	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H7K74_RS35165	COG3708	Transcriptional regulator
H7K74_RS35165	COG2207	Transcriptional regulator
H7K74_RS35170	COG4948	Mandelate Racemase Muconate Lactonizing
H7K74_RS35195	COG4251	negative regulation of phosphorylation
H7K74_RS35195	COG3706	GGDEF domain
H7K74_RS35195	COG5001	Diguanylate cyclase
H7K74_RS35195	COG2203	Gaf domain
H7K74_RS35210	COG1672	PFAM Archaeal ATPase
H7K74_RS35210	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H7K74_RS35220	COG4172	Belongs to the ABC transporter superfamily
H7K74_RS35225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7K74_RS35230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K74_RS35235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K74_RS35240	COG0601	transmembrane transport
H7K74_RS35245	COG0747	negative chemotaxis
H7K74_RS35255	COG0784	Response regulator, receiver
H7K74_RS35255	COG4191	Histidine kinase
H7K74_RS35270	COG1231	oxidoreductase activity
H7K74_RS35330	COG4948	Mandelate Racemase Muconate Lactonizing
H7K74_RS35340	COG0386	Belongs to the glutathione peroxidase family
H7K74_RS35345	COG0154	amidase activity
H7K74_RS35360	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H7K74_RS35365	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
H7K74_RS35370	COG0535	radical SAM domain protein
H7K74_RS35375	COG0535	radical SAM domain protein
H7K74_RS35390	COG0493	'glutamate synthase
H7K74_RS35395	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H7K74_RS35395	COG0674	pyruvate-flavodoxin oxidoreductase activity
H7K74_RS35400	COG1013	pyruvate-flavodoxin oxidoreductase activity
H7K74_RS35455	COG2719	SpoVR family
H7K74_RS35460	COG2718	Belongs to the UPF0229 family
H7K74_RS35465	COG2766	serine protein kinase
H7K74_RS35475	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7K74_RS35480	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H7K74_RS35485	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H7K74_RS35490	COG0363	glucosamine-6-phosphate deaminase activity
H7K74_RS35495	COG3265	gluconokinase activity
H7K74_RS35505	COG3387	PFAM Glycoside hydrolase 15-related
H7K74_RS35510	COG1640	4-alpha-glucanotransferase
H7K74_RS35515	COG0366	Alpha amylase catalytic
H7K74_RS35520	COG0366	Alpha amylase catalytic
H7K74_RS35525	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H7K74_RS35535	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H7K74_RS35560	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H7K74_RS35565	COG0745	RESPONSE REGULATOR receiver
H7K74_RS35570	COG2205	protein histidine kinase activity
H7K74_RS35575	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H7K74_RS35580	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H7K74_RS35585	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H7K74_RS35615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7K74_RS35635	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H7K74_RS35640	COG0318	PFAM AMP-dependent synthetase and ligase
H7K74_RS35645	COG0427	acetyl-CoA hydrolase
H7K74_RS35675	COG2030	dehydratase
H7K74_RS35710	COG0477	Major facilitator Superfamily
H7K74_RS35725	COG1053	succinate dehydrogenase
H7K74_RS35730	COG1414	Transcriptional regulator
H7K74_RS35735	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS35740	COG0028	Belongs to the TPP enzyme family
H7K74_RS35740	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
H7K74_RS35760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K74_RS35765	COG0028	Belongs to the TPP enzyme family
H7K74_RS35770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7K74_RS35800	COG2272	Belongs to the type-B carboxylesterase lipase family
H7K74_RS35805	COG0477	Major facilitator Superfamily
H7K74_RS35810	COG1309	transcriptional regulator
H7K74_RS35815	COG4208	sulfate ABC transporter
H7K74_RS35820	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7K74_RS35830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K74_RS35840	COG3842	ATPase activity
H7K74_RS35845	COG0583	DNA-binding transcription factor activity
H7K74_RS35855	COG1063	alcohol dehydrogenase
H7K74_RS35860	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H7K74_RS35870	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H7K74_RS35880	COG0246	Mannitol dehydrogenase
H7K74_RS35905	COG0412	Dienelactone hydrolase
H7K74_RS35945	COG1684	flagellar biosynthetic protein fliR
H7K74_RS35950	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H7K74_RS35955	COG4794	Type iii secretion
H7K74_RS35960	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H7K74_RS35965	COG5443	negative regulation of bacterial-type flagellum assembly
H7K74_RS35985	COG1749	Flagellar hook protein flgE
H7K74_RS36005	COG1360	Flagellar Motor Protein
H7K74_RS36020	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7K74_RS36025	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7K74_RS36030	COG1338	Plays a role in the flagellum-specific transport system
H7K74_RS36040	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H7K74_RS36050	COG1706	bacterial-type flagellum-dependent cell motility
H7K74_RS36060	COG4786	Flagellar basal body rod
H7K74_RS36065	COG1677	Flagellar hook-basal body complex protein FliE
H7K74_RS36070	COG1558	bacterial-type flagellum-dependent cell motility
H7K74_RS36075	COG1815	bacterial-type flagellum-dependent cell motility
H7K74_RS36080	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H7K74_RS36085	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7K74_RS36090	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7K74_RS36105	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7K74_RS36115	COG4786	Flagellar basal body rod
H7K74_RS36120	COG1157	protein secretion by the type III secretion system
H7K74_RS36125	COG1846	Transcriptional regulator
H7K74_RS36170	COG0411	ABC transporter
H7K74_RS36175	COG0559	Belongs to the binding-protein-dependent transport system permease family
H7K74_RS36180	COG0683	leucine binding
H7K74_RS36195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7K74_RS36200	COG1464	Belongs to the NlpA lipoprotein family
H7K74_RS36205	COG0534	Mate efflux family protein
H7K74_RS36210	COG1309	transcriptional regulator
H7K74_RS36215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7K74_RS36235	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
H7K74_RS36240	COG1126	abc transporter atp-binding protein
H7K74_RS36250	COG0765	amino acid transport
H7K74_RS36255	COG0765	amino acid transport
H7K74_RS36260	COG0673	inositol 2-dehydrogenase activity
H7K74_RS36280	COG1595	DNA-templated transcription, initiation
H7K74_RS36290	COG0477	Major facilitator Superfamily
H7K74_RS36310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K74_RS36310	COG4191	Histidine kinase
H7K74_RS36315	COG2204	response regulator
H7K74_RS36320	COG1024	Enoyl-CoA hydratase
H7K74_RS36320	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H7K74_RS36325	COG0309	Hydrogenase expression formation protein (HypE)
H7K74_RS36330	COG0409	Hydrogenase expression formation protein
H7K74_RS36375	COG1228	amidohydrolase
H7K74_RS36405	COG0583	DNA-binding transcription factor activity
H7K74_RS36410	COG0346	lactoylglutathione lyase activity
H7K74_RS36420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7K74_RS36450	COG2197	response regulator
H7K74_RS36465	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7K74_RS36480	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H7K74_RS36485	COG0459	protein refolding
H7K74_RS36495	COG1136	(ABC) transporter
H7K74_RS36495	COG0577	efflux transmembrane transporter activity
H7K74_RS36500	COG1136	(ABC) transporter
H7K74_RS36505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K74_RS36520	COG2072	flavoprotein involved in K transport
H7K74_RS36540	COG3920	Histidine kinase
H7K74_RS36575	COG0482	sulfurtransferase activity
H7K74_RS36585	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H7K74_RS36595	COG1766	The M ring may be actively involved in energy transduction
H7K74_RS36600	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7K74_RS36610	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7K74_RS36615	COG2204	response regulator
H7K74_RS36645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7K74_RS36650	COG1116	anion transmembrane transporter activity
H7K74_RS36655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K74_RS36660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7K74_RS36665	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7K74_RS36670	COG2124	cytochrome p450
H7K74_RS36695	COG0784	Response regulator, receiver
H7K74_RS36695	COG2205	protein histidine kinase activity
H7K74_RS36740	COG1309	transcriptional regulator
H7K74_RS36790	COG4689	acetoacetate decarboxylase
H7K74_RS36795	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS36815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7K74_RS36840	COG0243	molybdopterin cofactor binding
H7K74_RS36845	COG3043	anaerobic respiration
H7K74_RS36850	COG3005	denitrification pathway
H7K74_RS36855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7K74_RS36865	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7K74_RS36870	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7K74_RS36915	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H7K74_RS36920	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H7K74_RS36970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7K74_RS36980	COG1175	transmembrane transport
H7K74_RS36985	COG0395	ABC-type sugar transport system, permease component
H7K74_RS36990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7K74_RS36995	COG0596	Alpha beta hydrolase
H7K74_RS37015	COG0848	biopolymer transport protein
H7K74_RS37035	COG4771	TonB-dependent receptor
H7K74_RS37050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7K74_RS37055	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H7K74_RS37065	COG4566	intracellular signal transduction
H7K74_RS37090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7K74_RS37100	COG2847	Copper chaperone PCu(A)C
H7K74_RS37135	COG1301	dicarboxylic acid transport
H7K74_RS37140	COG2828	Protein conserved in bacteria
H7K74_RS37155	COG1175	transmembrane transport
H7K74_RS37170	COG1177	transmembrane transport
H7K74_RS37175	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7K74_RS37180	COG3842	ATPase activity
H7K74_RS37190	COG5001	Diguanylate cyclase
H7K74_RS37190	COG3300	MHYT domain
H7K74_RS37220	COG5002	protein histidine kinase activity
H7K74_RS37220	COG5001	Diguanylate cyclase
H7K74_RS37220	COG3447	MASE1 domain protein
H7K74_RS37225	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H7K74_RS37230	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H7K74_RS37240	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7K74_RS37245	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H7K74_RS37265	COG0387	Pfam Sodium calcium exchanger
H7K74_RS37315	COG2204	response regulator
H7K74_RS37320	COG2989	Protein conserved in bacteria
H7K74_RS37335	COG3750	Belongs to the UPF0335 family
H7K74_RS37350	COG0469	pyruvate kinase activity
H7K74_RS37355	COG1309	transcriptional regulator
H7K74_RS37390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7K74_RS37395	COG0037	tRNA processing
H7K74_RS37405	COG2885	chlorophyll binding
H7K74_RS37415	COG5001	Diguanylate cyclase
H7K74_RS37420	COG0823	Involved in the tonB-independent uptake of proteins
H7K74_RS37450	COG1045	serine acetyltransferase
H7K74_RS37495	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS37525	COG4941	Belongs to the sigma-70 factor family
H7K74_RS37530	COG3795	YCII-related domain
H7K74_RS37535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7K74_RS37550	COG0625	glutathione transferase activity
H7K74_RS37580	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H7K74_RS37605	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS37610	COG2233	PERMEase
H7K74_RS37615	COG1301	dicarboxylic acid transport
H7K74_RS37620	COG0488	(ABC) transporter
H7K74_RS37650	COG1177	transmembrane transport
H7K74_RS37655	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7K74_RS37660	COG3842	ATPase activity
H7K74_RS37675	COG0402	S-adenosylhomocysteine deaminase activity
H7K74_RS37695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K74_RS37705	COG0765	amino acid transport
H7K74_RS37725	COG0519	Catalyzes the synthesis of GMP from XMP
H7K74_RS37725	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7K74_RS37735	COG0824	Thioesterase
H7K74_RS37740	COG0824	Thioesterase
H7K74_RS37805	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7K74_RS37835	COG1376	ErfK ybiS ycfS ynhG family protein
H7K74_RS37845	COG0028	Belongs to the TPP enzyme family
H7K74_RS37850	COG1376	ErfK ybiS ycfS ynhG family protein
H7K74_RS37850	COG1388	LysM domain
H7K74_RS37860	COG2226	methyltransferase
H7K74_RS37870	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7K74_RS37885	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H7K74_RS37890	COG0501	Belongs to the peptidase M48B family
H7K74_RS37910	COG0583	DNA-binding transcription factor activity
H7K74_RS37915	COG1960	acyl-CoA dehydrogenase activity
H7K74_RS37925	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
H7K74_RS37945	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS37950	COG1272	protein, Hemolysin III
H7K74_RS37955	COG3106	COG3106 Predicted ATPase
H7K74_RS37960	COG3768	UPF0283 membrane protein
H7K74_RS37985	COG1278	Cold shock
H7K74_RS37995	COG0506	proline dehydrogenase activity
H7K74_RS37995	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H7K74_RS37995	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H7K74_RS38020	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H7K74_RS38025	COG1704	LemA family
H7K74_RS38030	COG1024	Enoyl-CoA hydratase
H7K74_RS38035	COG1960	acyl-CoA dehydrogenase activity
H7K74_RS38040	COG1960	acyl-CoA dehydrogenase activity
H7K74_RS38050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7K74_RS38055	COG2514	catechol 2,3-dioxygenase activity
H7K74_RS38060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7K74_RS38070	COG0402	S-adenosylhomocysteine deaminase activity
H7K74_RS38075	COG2205	protein histidine kinase activity
H7K74_RS38120	COG0028	Belongs to the TPP enzyme family
H7K74_RS38125	COG0800	Aldolase
H7K74_RS38130	COG3734	2-keto-3-deoxy-galactonokinase
H7K74_RS38140	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7K74_RS38145	COG3284	Transcriptional regulator
H7K74_RS38150	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H7K74_RS38155	COG0318	PFAM AMP-dependent synthetase and ligase
H7K74_RS38180	COG1309	transcriptional regulator
H7K74_RS38210	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7K74_RS38220	COG2197	response regulator
H7K74_RS38230	COG4585	Histidine kinase
H7K74_RS38240	COG2235	arginine
H7K74_RS38255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K74_RS38280	COG1320	monovalent cation:proton antiporter activity
H7K74_RS38290	COG1006	Multisubunit Na H antiporter MnhC subunit
H7K74_RS38295	COG0651	ATP synthesis coupled electron transport
H7K74_RS38305	COG0670	Belongs to the BI1 family
H7K74_RS38325	COG0628	permease
H7K74_RS38370	COG1615	UPF0182 protein
H7K74_RS38390	COG0564	pseudouridine synthase activity
H7K74_RS38395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7K74_RS38410	COG3706	GGDEF domain
H7K74_RS38415	COG1280	lysine exporter protein (LysE YggA)
H7K74_RS38455	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7K74_RS38460	COG0358	DNA primase activity
H7K74_RS38490	COG1280	lysine exporter protein (LysE YggA)
H7K74_RS38505	COG0640	Transcriptional regulator
H7K74_RS38530	COG0784	Response regulator, receiver
H7K74_RS38530	COG4191	Histidine kinase
H7K74_RS38550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7K74_RS38555	COG0596	Alpha beta hydrolase
H7K74_RS38570	COG0505	Belongs to the CarA family
H7K74_RS38600	COG2814	Major facilitator Superfamily
H7K74_RS38605	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H7K74_RS38610	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7K74_RS38615	COG1522	sequence-specific DNA binding
H7K74_RS38620	COG0492	ferredoxin-NADP+ reductase activity
H7K74_RS38625	COG0583	DNA-binding transcription factor activity
H7K74_RS38630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7K74_RS38665	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H7K74_RS38705	COG2205	protein histidine kinase activity
H7K74_RS38715	COG0183	Belongs to the thiolase family
H7K74_RS38720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7K74_RS38740	COG0625	glutathione transferase activity
H7K74_RS38755	COG2223	nitrite transmembrane transporter activity
H7K74_RS38760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7K74_RS38785	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7K74_RS38795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H7K74_RS38805	COG0436	Aminotransferase
H7K74_RS38815	COG0625	glutathione transferase activity
H7K74_RS38840	COG0667	Aldo Keto reductase
H7K74_RS38875	COG0583	DNA-binding transcription factor activity
H7K74_RS38890	COG0556	nucleotide-excision repair
H7K74_RS38940	COG2030	dehydratase
H7K74_RS38950	COG0012	GTP binding
H7K74_RS38955	COG0193	aminoacyl-tRNA hydrolase activity
H7K74_RS38960	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H7K74_RS38975	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H7K74_RS38985	COG1496	oxidoreductase activity
H7K74_RS38995	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H7K74_RS39005	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7K74_RS39010	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H7K74_RS39020	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H7K74_RS39030	COG1942	4-Oxalocrotonate Tautomerase
H7K74_RS39035	COG0124	histidyl-tRNA synthetase
H7K74_RS39050	COG1846	Transcriptional regulator
H7K74_RS39055	COG0745	RESPONSE REGULATOR receiver
H7K74_RS39085	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H7K74_RS39090	COG1278	Cold shock
H7K74_RS39095	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H7K74_RS39100	COG0322	excinuclease ABC activity
H7K74_RS39105	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H7K74_RS39115	COG0314	molybdopterin synthase activity
H7K74_RS39120	COG2890	protein-(glutamine-N5) methyltransferase activity
H7K74_RS39130	COG1295	ribonuclease BN
H7K74_RS39135	COG2200	EAL domain
H7K74_RS39135	COG2771	luxR family
H7K74_RS39145	COG0745	RESPONSE REGULATOR receiver
H7K74_RS39150	COG0196	riboflavin kinase activity
H7K74_RS39155	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H7K74_RS39160	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H7K74_RS39170	COG0612	Peptidase, M16
H7K74_RS39175	COG0612	Peptidase, M16
H7K74_RS39215	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H7K74_RS39220	COG0742	ribosomal rna small subunit methyltransferase
H7K74_RS39225	COG1187	pseudouridine synthase activity
H7K74_RS39230	COG0590	tRNA wobble adenosine to inosine editing
H7K74_RS39235	COG0596	Alpha beta hydrolase
H7K74_RS39240	COG0151	Belongs to the GarS family
H7K74_RS39285	COG1570	exodeoxyribonuclease VII activity
H7K74_RS39320	COG1663	tetraacyldisaccharide 4'-kinase activity
H7K74_RS39325	COG1519	Transferase
H7K74_RS39345	COG0312	modulator of DNA gyrase
H7K74_RS39355	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H7K74_RS39370	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H7K74_RS39375	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H7K74_RS39380	COG0463	Glycosyl transferase, family 2
H7K74_RS39390	COG3416	Protein conserved in bacteria
H7K74_RS39395	COG1388	LysM domain
H7K74_RS39395	COG1376	ErfK ybiS ycfS ynhG family protein
H7K74_RS39410	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H7K74_RS39415	COG0459	protein refolding
H7K74_RS39430	COG1620	l-lactate permease
H7K74_RS39435	COG4178	(ABC) transporter
H7K74_RS39450	COG0247	lactate metabolic process
H7K74_RS39455	COG0277	FAD linked oxidase domain protein
H7K74_RS39465	COG0277	FAD linked oxidase domain protein
H7K74_RS39470	COG3474	cytochrome
H7K74_RS39495	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H7K74_RS39530	COG0583	DNA-binding transcription factor activity
H7K74_RS39560	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H7K74_RS39580	COG0583	DNA-binding transcription factor activity
H7K74_RS39590	COG1741	Belongs to the pirin family
H7K74_RS39595	COG0655	NAD(P)H dehydrogenase (quinone) activity
H7K74_RS39600	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7K74_RS39620	COG1215	transferase activity, transferring glycosyl groups
H7K74_RS39630	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7K74_RS39645	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7K74_RS39660	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H7K74_RS39670	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7K74_RS39705	COG0583	DNA-binding transcription factor activity
H7K74_RS39720	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7K74_RS39730	COG1126	abc transporter atp-binding protein
H7K74_RS39735	COG0765	amino acid transport
H7K74_RS39740	COG0765	amino acid transport
H7K74_RS39775	COG1902	pentaerythritol trinitrate reductase activity
H7K74_RS39780	COG1012	belongs to the aldehyde dehydrogenase family
H7K74_RS39795	COG2146	nitrite reductase [NAD(P)H] activity
H7K74_RS39830	COG4166	transmembrane transport
H7K74_RS39835	COG1472	Belongs to the glycosyl hydrolase 3 family
H7K74_RS39845	COG0745	RESPONSE REGULATOR receiver
H7K74_RS39850	COG2205	protein histidine kinase activity
H7K74_RS39895	COG0826	peptidase U32
H7K74_RS39905	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H7K74_RS39940	COG1082	Xylose isomerase domain protein TIM barrel
H7K74_RS39945	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H7K74_RS39975	COG4297	protein containing double-stranded beta helix domain
H7K74_RS40005	COG0438	transferase activity, transferring glycosyl groups
H7K74_RS40030	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H7K74_RS40035	COG3685	Protein conserved in bacteria
H7K74_RS40040	COG0723	plastoquinol--plastocyanin reductase activity
H7K74_RS40040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K74_RS40045	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H7K74_RS40045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K74_RS40075	COG0546	phosphoglycolate phosphatase activity
H7K74_RS40165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K74_RS40180	COG0604	alcohol dehydrogenase
H7K74_RS40245	COG2267	carboxylic ester hydrolase activity
H7K74_RS40360	COG1335	isochorismatase
H7K74_RS40405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K74_RS40430	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H7K74_RS40470	COG0583	DNA-binding transcription factor activity
H7K74_RS40485	COG1280	lysine exporter protein (LysE YggA)
H7K74_RS40495	COG2010	Cytochrome c
H7K74_RS40505	COG0071	Belongs to the small heat shock protein (HSP20) family
H7K74_RS40520	COG0067	glutamate synthase
H7K74_RS40520	COG0069	glutamate synthase activity
H7K74_RS40520	COG0070	glutamate synthase
H7K74_RS40565	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H7K74_RS40575	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
H7K74_RS40605	COG0251	oxidation-reduction process
H7K74_RS40615	COG4689	acetoacetate decarboxylase
H7K74_RS40640	COG0523	cobalamin synthesis protein
H7K74_RS40645	COG0803	Belongs to the bacterial solute-binding protein 9 family
H7K74_RS40655	COG1121	(ABC) transporter
H7K74_RS40675	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H7K74_RS40710	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS40725	COG0318	PFAM AMP-dependent synthetase and ligase
H7K74_RS40750	COG0326	Molecular chaperone. Has ATPase activity
H7K74_RS40780	COG0784	Response regulator, receiver
H7K74_RS40795	COG0778	Nitroreductase
H7K74_RS40800	COG1960	acyl-CoA dehydrogenase activity
H7K74_RS40805	COG1960	acyl-CoA dehydrogenase activity
H7K74_RS40810	COG1960	acyl-CoA dehydrogenase activity
H7K74_RS40815	COG0318	PFAM AMP-dependent synthetase and ligase
H7K74_RS40840	COG0318	PFAM AMP-dependent synthetase and ligase
H7K74_RS40850	COG2267	carboxylic ester hydrolase activity
H7K74_RS40865	COG1595	DNA-templated transcription, initiation
H7K74_RS40875	COG5285	phytanoyl-CoA dioxygenase
H7K74_RS40885	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H7K74_RS40895	COG1960	acyl-CoA dehydrogenase activity
H7K74_RS40900	COG0183	Belongs to the thiolase family
H7K74_RS40905	COG0318	PFAM AMP-dependent synthetase and ligase
H7K74_RS40930	COG0559	Belongs to the binding-protein-dependent transport system permease family
H7K74_RS40985	COG0583	DNA-binding transcription factor activity
H7K74_RS41010	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H7K74_RS41025	COG1024	Enoyl-CoA hydratase
H7K74_RS41030	COG0318	PFAM AMP-dependent synthetase and ligase
H7K74_RS41030	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS41030	COG3321	synthase
H7K74_RS41030	COG0300	oxidoreductase activity
H7K74_RS41030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7K74_RS41090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7K74_RS41095	COG1024	Enoyl-CoA hydratase
H7K74_RS41110	COG2378	regulation of single-species biofilm formation
H7K74_RS41125	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7K74_RS41130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7K74_RS41135	COG0318	PFAM AMP-dependent synthetase and ligase
H7K74_RS41150	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7K74_RS41155	COG1879	ABC-type sugar transport system periplasmic component
H7K74_RS41170	COG1129	ABC transporter
H7K74_RS41175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K74_RS41180	COG1129	ABC transporter
H7K74_RS41180	COG0842	Transport permease protein
H7K74_RS41185	COG0842	Transport permease protein
H7K74_RS41215	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS41220	COG0640	Transcriptional regulator
H7K74_RS41265	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H7K74_RS41285	COG4245	von Willebrand factor, type A
H7K74_RS41300	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
H7K74_RS41315	COG4372	Transposase
H7K74_RS41335	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7K74_RS41355	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS41365	COG1028	Short-chain dehydrogenase reductase Sdr
H7K74_RS41380	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7K74_RS41395	COG2267	carboxylic ester hydrolase activity
H7K74_RS41405	COG0154	amidase activity
H7K74_RS41415	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H7K74_RS41420	COG1960	acyl-CoA dehydrogenase activity
H7K74_RS41425	COG4221	oxidoreductase activity
H7K74_RS41430	COG1024	Enoyl-CoA hydratase
H7K74_RS41445	COG0583	DNA-binding transcription factor activity
H7K74_RS41470	COG1546	Belongs to the CinA family
H7K74_RS41470	COG1058	Belongs to the CinA family
H7K74_RS41485	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H7K74_RS41490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K74_RS41495	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
H7K74_RS41505	COG0444	Belongs to the ABC transporter superfamily
H7K74_RS41510	COG0154	amidase activity
H7K74_RS41520	COG4608	Belongs to the ABC transporter superfamily
H7K74_RS41525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K74_RS41535	COG0747	negative chemotaxis
H7K74_RS41540	COG0747	negative chemotaxis
H7K74_RS41610	COG0588	phosphoglycerate mutase activity
H7K74_RS41630	COG2309	aminopeptidase activity
H7K74_RS41635	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H7K74_RS41660	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H7K74_RS41670	COG3454	Phosphonate metabolism
H7K74_RS41675	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
H7K74_RS41700	COG1024	Enoyl-CoA hydratase
H7K74_RS41710	COG1309	transcriptional regulator
H7K74_RS41730	COG0071	Belongs to the small heat shock protein (HSP20) family
H7K74_RS41735	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H7K74_RS41740	COG2610	gluconate transmembrane transporter activity
H7K74_RS41750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7K74_RS41765	COG4774	siderophore transport
H7K74_RS41770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7K74_RS41775	COG0277	FAD linked oxidase domain protein
H7K74_RS41780	COG1802	Transcriptional regulator
H7K74_RS41790	COG1032	radical SAM domain protein
H7K74_RS41795	COG1959	2 iron, 2 sulfur cluster binding
H7K74_RS41820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7K74_RS41835	COG2264	protein methyltransferase activity
H7K74_RS41870	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
H7K74_RS41900	COG2902	Dehydrogenase
H7K74_RS41930	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H7K74_RS41935	COG3300	MHYT domain
H7K74_RS41935	COG5001	Diguanylate cyclase
H7K74_RS41950	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H7K74_RS41955	COG0594	ribonuclease P activity
H7K74_RS41960	COG0706	membrane insertase activity
H7K74_RS41965	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H7K74_RS41975	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H7K74_RS41990	COG2171	N-acyltransferase activity
H7K74_RS41995	COG3152	Membrane
H7K74_RS42000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7K74_RS42005	COG0101	tRNA pseudouridine synthase activity
H7K74_RS42010	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H7K74_RS42015	COG0242	peptide deformylase activity
H7K74_RS42030	COG2223	nitrite transmembrane transporter activity
H7K74_RS42040	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H7K74_RS42045	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H7K74_RS42050	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H7K74_RS42060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K74_RS42065	COG0765	amino acid transport
H7K74_RS42095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7K74_RS42100	COG1522	sequence-specific DNA binding
H7K74_RS42105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7K74_RS42110	COG3577	Aspartyl protease
H7K74_RS42115	COG1643	Atp-dependent helicase
H7K74_RS42120	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H7K74_RS42130	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7K74_RS42130	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7K74_RS42135	COG1280	lysine exporter protein (LysE YggA)
H7K74_RS42140	COG0625	glutathione transferase activity
H7K74_RS42145	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H7K74_RS42155	COG2801	Transposase and inactivated derivatives
H7K74_RS42155	COG3415	Transposase
H7K74_RS42165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7K74_RS42175	COG0058	SHG alpha-glucan phosphorylase activity
H7K74_RS42185	COG3415	Transposase
H7K74_RS42185	COG2801	Transposase and inactivated derivatives
H7K74_RS42205	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H7K74_RS42220	COG0745	RESPONSE REGULATOR receiver
H7K74_RS42225	COG2205	protein histidine kinase activity
H7K74_RS42235	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7K74_RS42235	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7K74_RS42250	COG0481	GTPase activity
H7K74_RS42270	COG1794	racemase activity, acting on amino acids and derivatives
H7K74_RS42280	COG1960	acyl-CoA dehydrogenase activity
H7K74_RS42285	COG5001	Diguanylate cyclase
H7K74_RS42295	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
H7K74_RS42305	COG0725	ABC transporter, periplasmic molybdate-binding protein
H7K74_RS42310	COG4149	molybdate abc transporter
H7K74_RS42315	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H7K74_RS42320	COG0438	transferase activity, transferring glycosyl groups
H7K74_RS42330	COG0586	Pfam SNARE associated Golgi protein
H7K74_RS42340	COG3263	regulation of cellular component size
H7K74_RS42345	COG3264	Mechanosensitive ion channel
H7K74_RS42345	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H7K74_RS42350	COG0024	Methionine aminopeptidase
H7K74_RS42365	COG2003	Belongs to the UPF0758 family
H7K74_RS42370	COG0582	viral genome integration into host DNA
H7K74_RS42375	COG4804	nuclease activity
H7K74_RS42385	COG0419	ATPase involved in DNA repair
H7K74_RS42415	COG3293	Transposase
H7K74_RS42430	COG1309	transcriptional regulator
H7K74_RS42435	COG1376	ErfK ybiS ycfS ynhG family protein
H7K74_RS42440	COG0300	oxidoreductase activity
H7K74_RS42525	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H7K74_RS42595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7K74_RS42615	COG4584	PFAM Integrase catalytic
H7K74_RS42655	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7K74_RS42665	COG0405	Gamma-glutamyltransferase
H7K74_RS42695	COG3436	PFAM IS66 Orf2 family protein
H7K74_RS42715	COG3831	ATPase activity
H7K74_RS42775	COG1278	Cold shock
H7K74_RS42885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7K74_RS42895	COG0583	DNA-binding transcription factor activity
H7K74_RS42915	COG0596	Alpha beta hydrolase
H7K74_RS42925	COG2948	multi-organism process
H7K74_RS42935	COG3701	Conjugal transfer protein
H7K74_RS42955	COG3451	type IV secretory pathway VirB4
H7K74_RS42965	COG3838	Conjugal transfer protein Trbc
H7K74_RS42970	COG4962	Type ii secretion system protein e
H7K74_RS42995	COG5265	(ABC) transporter
H7K74_RS43020	COG3547	Transposase (IS116 IS110 IS902 family)
H7K74_RS43050	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7K74_RS43060	COG0776	regulation of translation
H7K74_RS43070	COG3344	reverse transcriptase
H7K74_RS43075	COG2801	Transposase and inactivated derivatives