locus-tag	class	description
NK6_RS00020	COG3706	GGDEF domain
NK6_RS00025	COG2801	Transposase and inactivated derivatives
NK6_RS00030	COG4227	nucleotidyltransferase activity
NK6_RS00050	COG0583	DNA-binding transcription factor activity
NK6_RS00060	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS00085	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS00110	COG0673	inositol 2-dehydrogenase activity
NK6_RS00130	COG2801	Transposase and inactivated derivatives
NK6_RS00175	COG2771	luxR family
NK6_RS00200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NK6_RS00240	COG4372	Transposase
NK6_RS00270	COG4717	serine-type aminopeptidase activity
NK6_RS00350	COG4423	Transcription factor
NK6_RS00355	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
NK6_RS00360	COG0640	Transcriptional regulator
NK6_RS00365	COG1475	DNA binding
NK6_RS00370	COG1192	Involved in chromosome partitioning
NK6_RS00380	COG4962	Type ii secretion system protein e
NK6_RS00400	COG5314	conjugation
NK6_RS00410	COG3846	protein secretion by the type IV secretion system
NK6_RS00415	COG3701	Conjugal transfer protein
NK6_RS00480	COG2801	Transposase and inactivated derivatives
NK6_RS00485	COG2801	Transposase and inactivated derivatives
NK6_RS00610	COG4372	Transposase
NK6_RS00615	COG4584	PFAM Integrase catalytic
NK6_RS00625	COG4372	Transposase
NK6_RS00630	COG0129	dihydroxy-acid dehydratase activity
NK6_RS00655	COG2801	Transposase and inactivated derivatives
NK6_RS00655	COG3415	Transposase
NK6_RS00685	COG4584	PFAM Integrase catalytic
NK6_RS00690	COG1484	DNA-dependent DNA replication
NK6_RS00695	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS00720	COG4886	Leucine-rich repeat (LRR) protein
NK6_RS00730	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NK6_RS00755	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NK6_RS00875	COG2801	Transposase and inactivated derivatives
NK6_RS00900	COG4886	Leucine-rich repeat (LRR) protein
NK6_RS00925	COG3831	ATPase activity
NK6_RS00930	COG4584	PFAM Integrase catalytic
NK6_RS00935	COG3344	reverse transcriptase
NK6_RS00940	COG3547	Transposase (IS116 IS110 IS902 family)
NK6_RS00955	COG4372	Transposase
NK6_RS00965	COG2801	Transposase and inactivated derivatives
NK6_RS00970	COG5001	Diguanylate cyclase
NK6_RS00970	COG3300	MHYT domain
NK6_RS01015	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NK6_RS01040	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NK6_RS01080	COG1733	regulation of RNA biosynthetic process
NK6_RS01095	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS01105	COG4584	PFAM Integrase catalytic
NK6_RS01110	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS01115	COG3181	Tripartite tricarboxylate transporter family receptor
NK6_RS01120	COG0203	ribosomal protein L17
NK6_RS01125	COG0202	RNA polymerase activity
NK6_RS01130	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NK6_RS01135	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NK6_RS01140	COG0563	adenylate kinase activity
NK6_RS01150	COG0200	Binds to the 23S rRNA
NK6_RS01155	COG1841	ribosomal large subunit assembly
NK6_RS01160	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NK6_RS01165	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NK6_RS01170	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NK6_RS01175	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NK6_RS01180	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NK6_RS01185	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NK6_RS01190	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NK6_RS01195	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NK6_RS01200	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NK6_RS01205	COG0255	Belongs to the universal ribosomal protein uL29 family
NK6_RS01210	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NK6_RS01215	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NK6_RS01220	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NK6_RS01225	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NK6_RS01230	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NK6_RS01235	COG0089	rRNA binding
NK6_RS01240	COG0088	Forms part of the polypeptide exit tunnel
NK6_RS01245	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NK6_RS01250	COG0051	transcription antitermination factor activity, RNA binding
NK6_RS01255	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NK6_RS01260	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NK6_RS01265	COG0049	tRNA binding
NK6_RS01270	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NK6_RS01285	COG1231	oxidoreductase activity
NK6_RS01290	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NK6_RS01295	COG0085	RNA polymerase activity
NK6_RS01300	COG0222	ribosome binding
NK6_RS01305	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NK6_RS01310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NK6_RS01315	COG0081	regulation of translation
NK6_RS01320	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NK6_RS01325	COG0250	Participates in transcription elongation, termination and antitermination
NK6_RS01330	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NK6_RS01350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NK6_RS01355	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NK6_RS01355	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NK6_RS01360	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NK6_RS01385	COG3959	Transketolase, thiamine diphosphate binding domain
NK6_RS01390	COG3958	Transketolase
NK6_RS01415	COG2226	methyltransferase
NK6_RS01435	COG0673	inositol 2-dehydrogenase activity
NK6_RS01470	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS01480	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS01510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NK6_RS01515	COG1280	lysine exporter protein (LysE YggA)
NK6_RS01525	COG1960	acyl-CoA dehydrogenase activity
NK6_RS01545	COG3246	L-lysine catabolic process to acetate
NK6_RS01550	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NK6_RS01560	COG3246	L-lysine catabolic process to acetate
NK6_RS01580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NK6_RS01600	COG2274	protein secretion by the type I secretion system
NK6_RS01645	COG0437	4 iron, 4 sulfur cluster binding
NK6_RS01715	COG4191	Histidine kinase
NK6_RS01715	COG0784	Response regulator, receiver
NK6_RS01735	COG3795	YCII-related domain
NK6_RS01745	COG0210	DNA helicase
NK6_RS01750	COG0402	S-adenosylhomocysteine deaminase activity
NK6_RS01760	COG0477	Major facilitator Superfamily
NK6_RS01780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NK6_RS01800	COG2801	Transposase and inactivated derivatives
NK6_RS01860	COG2801	Transposase and inactivated derivatives
NK6_RS01950	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NK6_RS01975	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NK6_RS01980	COG0302	gtp cyclohydrolase
NK6_RS01995	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NK6_RS02015	COG0477	Major facilitator Superfamily
NK6_RS02055	COG2814	Major facilitator Superfamily
NK6_RS02060	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NK6_RS02065	COG5295	Hep Hag repeat protein
NK6_RS02085	COG5001	Diguanylate cyclase
NK6_RS02090	COG2801	Transposase and inactivated derivatives
NK6_RS02105	COG0604	alcohol dehydrogenase
NK6_RS02105	COG4221	oxidoreductase activity
NK6_RS02105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NK6_RS02105	COG3321	synthase
NK6_RS02115	COG0667	Aldo Keto reductase
NK6_RS02130	COG1752	Esterase of the alpha-beta hydrolase superfamily
NK6_RS02135	COG0517	IMP dehydrogenase activity
NK6_RS02155	COG3920	Histidine kinase
NK6_RS02180	COG2261	transglycosylase associated protein
NK6_RS02295	COG4584	PFAM Integrase catalytic
NK6_RS02305	COG2801	Transposase and inactivated derivatives
NK6_RS02335	COG1278	Cold shock
NK6_RS02430	COG0513	Belongs to the DEAD box helicase family
NK6_RS02450	COG1063	alcohol dehydrogenase
NK6_RS02480	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NK6_RS02495	COG3842	ATPase activity
NK6_RS02505	COG1176	ABC-type spermidine putrescine transport system, permease component I
NK6_RS02570	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NK6_RS02585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NK6_RS02605	COG2814	Major facilitator Superfamily
NK6_RS02615	COG0747	negative chemotaxis
NK6_RS02625	COG0601	transmembrane transport
NK6_RS02630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NK6_RS02635	COG4172	Belongs to the ABC transporter superfamily
NK6_RS02645	COG1473	amidohydrolase
NK6_RS02650	COG0154	amidase activity
NK6_RS02655	COG1024	Enoyl-CoA hydratase
NK6_RS02670	COG0625	glutathione transferase activity
NK6_RS02685	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
NK6_RS02690	COG1546	Belongs to the CinA family
NK6_RS02690	COG1058	Belongs to the CinA family
NK6_RS02695	COG2308	Evidence 4 Homologs of previously reported genes of
NK6_RS02725	COG4221	oxidoreductase activity
NK6_RS02740	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NK6_RS02755	COG5425	PFAM Usg family protein
NK6_RS02760	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NK6_RS02765	COG0459	protein refolding
NK6_RS02805	COG1335	isochorismatase
NK6_RS02875	COG0384	phenazine biosynthesis protein PhzF
NK6_RS02885	COG2814	Major facilitator Superfamily
NK6_RS02890	COG2188	Transcriptional regulator
NK6_RS02905	COG0842	Transport permease protein
NK6_RS02910	COG1131	(ABC) transporter
NK6_RS02925	COG0640	Transcriptional regulator
NK6_RS02965	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NK6_RS02965	COG3608	succinylglutamate desuccinylase aspartoacylase
NK6_RS03000	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NK6_RS03005	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NK6_RS03010	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NK6_RS03050	COG2204	response regulator
NK6_RS03055	COG0784	Response regulator, receiver
NK6_RS03055	COG4191	Histidine kinase
NK6_RS03085	COG2815	serine threonine protein kinase
NK6_RS03085	COG0515	serine threonine protein kinase
NK6_RS03115	COG2197	response regulator
NK6_RS03125	COG1309	transcriptional regulator
NK6_RS03130	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NK6_RS03165	COG0318	PFAM AMP-dependent synthetase and ligase
NK6_RS03170	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NK6_RS03210	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NK6_RS03230	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
NK6_RS03235	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NK6_RS03240	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NK6_RS03245	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
NK6_RS03275	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NK6_RS03295	COG0047	phosphoribosylformylglycinamidine synthase activity
NK6_RS03305	COG0598	Magnesium transport protein CorA
NK6_RS03310	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NK6_RS03315	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NK6_RS03325	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
NK6_RS03330	COG1116	anion transmembrane transporter activity
NK6_RS03330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NK6_RS03335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NK6_RS03340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NK6_RS03350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NK6_RS03365	COG1309	transcriptional regulator
NK6_RS03375	COG2020	methyltransferase activity
NK6_RS03400	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
NK6_RS03405	COG0538	isocitrate dehydrogenase activity
NK6_RS03415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NK6_RS03420	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NK6_RS03425	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NK6_RS03430	COG0509	glycine decarboxylation via glycine cleavage system
NK6_RS03435	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NK6_RS03435	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NK6_RS03445	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NK6_RS03550	COG0640	Transcriptional regulator
NK6_RS03555	COG0446	pyridine nucleotide-disulphide oxidoreductase
NK6_RS03595	COG1879	ABC-type sugar transport system periplasmic component
NK6_RS03600	COG1172	Belongs to the binding-protein-dependent transport system permease family
NK6_RS03610	COG1070	Carbohydrate kinase
NK6_RS03660	COG2917	probably involved in intracellular septation
NK6_RS03675	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
NK6_RS03675	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
NK6_RS03700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NK6_RS03705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NK6_RS03730	COG4584	PFAM Integrase catalytic
NK6_RS03750	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NK6_RS03755	COG1684	flagellar biosynthetic protein fliR
NK6_RS03760	COG1987	bacterial-type flagellum assembly
NK6_RS03765	COG1677	Flagellar hook-basal body complex protein FliE
NK6_RS03770	COG1558	bacterial-type flagellum-dependent cell motility
NK6_RS03785	COG1338	Plays a role in the flagellum-specific transport system
NK6_RS03835	COG4786	Flagellar basal body rod
NK6_RS03840	COG4786	Flagellar basal body rod
NK6_RS03850	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
NK6_RS03855	COG3971	2-oxopent-4-enoate hydratase activity
NK6_RS03860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NK6_RS03865	COG1733	regulation of RNA biosynthetic process
NK6_RS03875	COG2910	NAD(P)H-binding
NK6_RS03880	COG1733	regulation of RNA biosynthetic process
NK6_RS03890	COG1706	bacterial-type flagellum-dependent cell motility
NK6_RS03910	COG5442	Flagellar protein FlaF
NK6_RS03915	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NK6_RS03920	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NK6_RS03925	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NK6_RS03930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NK6_RS03935	COG5443	negative regulation of bacterial-type flagellum assembly
NK6_RS03940	COG0076	glutamate decarboxylase activity
NK6_RS03965	COG1256	bacterial-type flagellum assembly
NK6_RS03985	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NK6_RS04010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NK6_RS04030	COG3300	MHYT domain
NK6_RS04030	COG5001	Diguanylate cyclase
NK6_RS04040	COG3685	Protein conserved in bacteria
NK6_RS04055	COG2271	Major facilitator Superfamily
NK6_RS04060	COG0583	DNA-binding transcription factor activity
NK6_RS04065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NK6_RS04075	COG1012	belongs to the aldehyde dehydrogenase family
NK6_RS04080	COG2721	sulfolactate sulfo-lyase activity
NK6_RS04095	COG0745	RESPONSE REGULATOR receiver
NK6_RS04125	COG0492	ferredoxin-NADP+ reductase activity
NK6_RS04135	COG0633	Ferredoxin
NK6_RS04165	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NK6_RS04165	COG3218	ABC-type transport auxiliary lipoprotein component
NK6_RS04170	COG1127	ABC transporter
NK6_RS04175	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NK6_RS04180	COG4948	Mandelate Racemase Muconate Lactonizing
NK6_RS04185	COG2814	Major facilitator Superfamily
NK6_RS04200	COG4154	Belongs to the RbsD FucU family
NK6_RS04230	COG0351	phosphomethylpyrimidine kinase
NK6_RS04235	COG0784	Response regulator, receiver
NK6_RS04235	COG4191	Histidine kinase
NK6_RS04250	COG2010	Cytochrome c
NK6_RS04270	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NK6_RS04275	COG3909	cytochrome
NK6_RS04305	COG0673	inositol 2-dehydrogenase activity
NK6_RS04310	COG0662	Cupin 2, conserved barrel domain protein
NK6_RS04310	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
NK6_RS04325	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NK6_RS04345	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NK6_RS04345	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NK6_RS04355	COG0859	PFAM glycosyl transferase family 9
NK6_RS04370	COG1132	(ABC) transporter
NK6_RS04390	COG0583	DNA-binding transcription factor activity
NK6_RS04395	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS04400	COG1942	4-Oxalocrotonate Tautomerase
NK6_RS04415	COG0489	protein tyrosine kinase activity
NK6_RS04430	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NK6_RS04435	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NK6_RS04450	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NK6_RS04520	COG0318	PFAM AMP-dependent synthetase and ligase
NK6_RS04525	COG0559	Belongs to the binding-protein-dependent transport system permease family
NK6_RS04545	COG2942	2-epimerase
NK6_RS04555	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NK6_RS04570	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
NK6_RS04570	COG0662	Cupin 2, conserved barrel domain protein
NK6_RS04590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NK6_RS04610	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NK6_RS04630	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NK6_RS04635	COG0438	transferase activity, transferring glycosyl groups
NK6_RS04635	COG1216	Glycosyl transferase, family 2
NK6_RS04660	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
NK6_RS04695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NK6_RS04710	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NK6_RS04725	COG3181	Tripartite tricarboxylate transporter family receptor
NK6_RS04740	COG1024	Enoyl-CoA hydratase
NK6_RS04745	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NK6_RS04755	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NK6_RS04760	COG1802	Transcriptional regulator
NK6_RS04825	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NK6_RS04895	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NK6_RS04905	COG3181	Tripartite tricarboxylate transporter family receptor
NK6_RS04910	COG2080	2 iron, 2 sulfur cluster binding
NK6_RS04925	COG0517	IMP dehydrogenase activity
NK6_RS04925	COG0516	GMP reductase activity
NK6_RS04940	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS04955	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NK6_RS04960	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
NK6_RS04970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NK6_RS04975	COG2010	Cytochrome c
NK6_RS04980	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NK6_RS04980	COG3218	ABC-type transport auxiliary lipoprotein component
NK6_RS04985	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NK6_RS05005	COG0045	succinate-CoA ligase (ADP-forming) activity
NK6_RS05005	COG1042	CoA-binding domain protein
NK6_RS05005	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NK6_RS05030	COG3243	poly(R)-hydroxyalkanoic acid synthase
NK6_RS05035	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NK6_RS05035	COG0617	tRNA 3'-terminal CCA addition
NK6_RS05035	COG0517	IMP dehydrogenase activity
NK6_RS05040	COG0251	oxidation-reduction process
NK6_RS05070	COG1024	Enoyl-CoA hydratase
NK6_RS05075	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS05085	COG1960	acyl-CoA dehydrogenase activity
NK6_RS05090	COG0318	PFAM AMP-dependent synthetase and ligase
NK6_RS05100	COG1250	3-hydroxyacyl-CoA dehydrogenase
NK6_RS05110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NK6_RS05115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NK6_RS05125	COG0129	dihydroxy-acid dehydratase activity
NK6_RS05170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NK6_RS05190	COG4608	Belongs to the ABC transporter superfamily
NK6_RS05195	COG0444	Belongs to the ABC transporter superfamily
NK6_RS05200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NK6_RS05205	COG0601	transmembrane transport
NK6_RS05210	COG0747	negative chemotaxis
NK6_RS05255	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
NK6_RS05255	COG1672	PFAM Archaeal ATPase
NK6_RS05295	COG4372	Transposase
NK6_RS05305	COG2801	Transposase and inactivated derivatives
NK6_RS05315	COG1408	metallophosphoesterase
NK6_RS05330	COG3547	Transposase (IS116 IS110 IS902 family)
NK6_RS05355	COG3415	Transposase
NK6_RS05355	COG2801	Transposase and inactivated derivatives
NK6_RS05405	COG4948	Mandelate Racemase Muconate Lactonizing
NK6_RS05415	COG3258	Cytochrome c
NK6_RS05425	COG0010	Belongs to the arginase family
NK6_RS05435	COG2203	Gaf domain
NK6_RS05435	COG3706	GGDEF domain
NK6_RS05435	COG4251	negative regulation of phosphorylation
NK6_RS05435	COG5001	Diguanylate cyclase
NK6_RS05455	COG2010	Cytochrome c
NK6_RS05530	COG2252	PERMEase
NK6_RS05535	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NK6_RS05545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NK6_RS05550	COG1301	dicarboxylic acid transport
NK6_RS05570	COG1079	Belongs to the binding-protein-dependent transport system permease family
NK6_RS05575	COG1079	Belongs to the binding-protein-dependent transport system permease family
NK6_RS05585	COG3845	ABC transporter
NK6_RS05600	COG3845	ABC transporter
NK6_RS05605	COG4603	Belongs to the binding-protein-dependent transport system permease family
NK6_RS05610	COG1079	Belongs to the binding-protein-dependent transport system permease family
NK6_RS05630	COG2080	2 iron, 2 sulfur cluster binding
NK6_RS05630	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NK6_RS05635	COG2233	PERMEase
NK6_RS05680	COG0235	Class ii aldolase
NK6_RS05685	COG2095	MarC family integral membrane protein
NK6_RS05700	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NK6_RS05705	COG0776	regulation of translation
NK6_RS05710	COG0183	Belongs to the thiolase family
NK6_RS05760	COG2197	response regulator
NK6_RS05765	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
NK6_RS05785	COG1131	(ABC) transporter
NK6_RS05920	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
NK6_RS05925	COG3791	Glutathione-dependent formaldehyde-activating
NK6_RS05945	COG0723	plastoquinol--plastocyanin reductase activity
NK6_RS05955	COG1250	3-hydroxyacyl-CoA dehydrogenase
NK6_RS05960	COG0277	FAD linked oxidase domain protein
NK6_RS05965	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NK6_RS05995	COG5001	Diguanylate cyclase
NK6_RS05995	COG3300	MHYT domain
NK6_RS06040	COG1309	transcriptional regulator
NK6_RS06045	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NK6_RS06050	COG2986	histidine ammonia-lyase
NK6_RS06055	COG1228	amidohydrolase
NK6_RS06060	COG1228	amidohydrolase
NK6_RS06075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NK6_RS06080	COG1116	anion transmembrane transporter activity
NK6_RS06090	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NK6_RS06100	COG4977	sequence-specific DNA binding
NK6_RS06100	COG1917	Cupin 2, conserved barrel domain protein
NK6_RS06105	COG2223	nitrite transmembrane transporter activity
NK6_RS06120	COG0656	L-ascorbic acid biosynthetic process
NK6_RS06130	COG1566	PFAM secretion protein HlyD family protein
NK6_RS06140	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NK6_RS06150	COG1764	response to oxidative stress
NK6_RS06160	COG0596	Alpha beta hydrolase
NK6_RS06200	COG2267	carboxylic ester hydrolase activity
NK6_RS06205	COG2169	Transcriptional regulator
NK6_RS06215	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
NK6_RS06235	COG1802	Transcriptional regulator
NK6_RS06240	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NK6_RS06255	COG2873	o-acetylhomoserine
NK6_RS06260	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NK6_RS06275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NK6_RS06280	COG0318	PFAM AMP-dependent synthetase and ligase
NK6_RS06295	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS06305	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
NK6_RS06315	COG2189	Belongs to the N(4) N(6)-methyltransferase family
NK6_RS06355	COG3344	reverse transcriptase
NK6_RS06360	COG2197	response regulator
NK6_RS06365	COG2197	response regulator
NK6_RS06380	COG2963	transposase activity
NK6_RS06385	COG3436	PFAM IS66 Orf2 family protein
NK6_RS06390	COG2433	Pfam Transposase IS66
NK6_RS06435	COG2801	Transposase and inactivated derivatives
NK6_RS06440	COG3436	PFAM IS66 Orf2 family protein
NK6_RS06445	COG4372	Transposase
NK6_RS06450	COG2963	transposase activity
NK6_RS06455	COG3436	PFAM IS66 Orf2 family protein
NK6_RS06475	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS06480	COG4372	Transposase
NK6_RS06490	COG4372	Transposase
NK6_RS06495	COG4372	Transposase
NK6_RS06525	COG0463	Glycosyl transferase, family 2
NK6_RS06545	COG0367	asparagine synthase
NK6_RS06555	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NK6_RS06570	COG2801	Transposase and inactivated derivatives
NK6_RS06625	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NK6_RS06630	COG1596	polysaccharide export
NK6_RS06635	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NK6_RS06685	COG2084	Dehydrogenase
NK6_RS06695	COG1129	ABC transporter
NK6_RS06715	COG1172	Belongs to the binding-protein-dependent transport system permease family
NK6_RS06725	COG1522	sequence-specific DNA binding
NK6_RS06770	COG0651	ATP synthesis coupled electron transport
NK6_RS06785	COG0651	ATP synthesis coupled electron transport
NK6_RS06790	COG0649	NAD binding
NK6_RS06795	COG3260	NADH ubiquinone oxidoreductase 20
NK6_RS06835	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NK6_RS06850	COG1181	Belongs to the D-alanine--D-alanine ligase family
NK6_RS06890	COG0673	inositol 2-dehydrogenase activity
NK6_RS06895	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NK6_RS06905	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NK6_RS06910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NK6_RS06920	COG1116	anion transmembrane transporter activity
NK6_RS06935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NK6_RS06945	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NK6_RS06950	COG0297	glycogen (starch) synthase activity
NK6_RS06960	COG4095	Psort location CytoplasmicMembrane, score
NK6_RS06990	COG2072	flavoprotein involved in K transport
NK6_RS07010	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NK6_RS07015	COG0281	malic enzyme
NK6_RS07025	COG0668	transmembrane transport
NK6_RS07040	COG2326	polyphosphate kinase activity
NK6_RS07105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NK6_RS07115	COG1125	glycine betaine transport
NK6_RS07115	COG0517	IMP dehydrogenase activity
NK6_RS07120	COG1174	glycine betaine transport
NK6_RS07145	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS07155	COG3300	MHYT domain
NK6_RS07155	COG5001	Diguanylate cyclase
NK6_RS07160	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NK6_RS07180	COG0440	acetolactate synthase activity
NK6_RS07190	COG0028	Belongs to the TPP enzyme family
NK6_RS07195	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NK6_RS07215	COG0330	HflC and HflK could
NK6_RS07220	COG0330	HflC and HflK could
NK6_RS07235	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NK6_RS07275	COG0114	fumarate hydratase activity
NK6_RS07365	COG1309	transcriptional regulator
NK6_RS07440	COG2202	Pas domain
NK6_RS07440	COG2199	diguanylate cyclase activity
NK6_RS07440	COG2200	EAL domain
NK6_RS07445	COG2271	Major facilitator Superfamily
NK6_RS07450	COG5001	Diguanylate cyclase
NK6_RS07450	COG3300	MHYT domain
NK6_RS07460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NK6_RS07465	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NK6_RS07470	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NK6_RS07475	COG2259	Doxx family
NK6_RS07480	COG0583	DNA-binding transcription factor activity
NK6_RS07505	COG0277	FAD linked oxidase domain protein
NK6_RS07515	COG5487	UPF0391 membrane protein
NK6_RS07520	COG0210	DNA helicase
NK6_RS07540	COG1088	dTDP-glucose 4,6-dehydratase activity
NK6_RS07555	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
NK6_RS07575	COG0071	Belongs to the small heat shock protein (HSP20) family
NK6_RS07600	COG2267	carboxylic ester hydrolase activity
NK6_RS07610	COG1131	(ABC) transporter
NK6_RS07615	COG0842	Transport permease protein
NK6_RS07635	COG0584	glycerophosphoryl diester phosphodiesterase
NK6_RS07660	COG2264	protein methyltransferase activity
NK6_RS07670	COG0006	proline dipeptidase activity
NK6_RS07670	COG0006	proline dipeptidase activity
NK6_RS07675	COG2814	Major facilitator Superfamily
NK6_RS07680	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NK6_RS07705	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NK6_RS07710	COG0849	cell division
NK6_RS07715	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NK6_RS07720	COG1181	Belongs to the D-alanine--D-alanine ligase family
NK6_RS07730	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NK6_RS07735	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NK6_RS07745	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NK6_RS07750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NK6_RS07755	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NK6_RS07760	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NK6_RS07775	COG0275	rRNA processing
NK6_RS07780	COG3023	N-Acetylmuramoyl-L-alanine amidase
NK6_RS07790	COG4941	Belongs to the sigma-70 factor family
NK6_RS07795	COG3795	YCII-related domain
NK6_RS07815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NK6_RS07835	COG5265	(ABC) transporter
NK6_RS07850	COG1309	transcriptional regulator
NK6_RS07890	COG0688	phosphatidylethanolamine metabolic process
NK6_RS07910	COG0438	transferase activity, transferring glycosyl groups
NK6_RS07915	COG1376	ErfK ybiS ycfS ynhG family protein
NK6_RS07915	COG1388	LysM domain
NK6_RS07920	COG3474	cytochrome
NK6_RS07925	COG2827	Endonuclease containing a URI domain
NK6_RS07965	COG3842	ATPase activity
NK6_RS07975	COG1176	ABC-type spermidine putrescine transport system, permease component I
NK6_RS08030	COG2022	thiamine diphosphate biosynthetic process
NK6_RS08040	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NK6_RS08065	COG0625	glutathione transferase activity
NK6_RS08115	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS08120	COG2204	response regulator
NK6_RS08145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NK6_RS08160	COG2193	ferroxidase activity
NK6_RS08200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NK6_RS08220	COG2897	thiosulfate sulfurtransferase activity
NK6_RS08225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NK6_RS08240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NK6_RS08265	COG2207	Transcriptional regulator
NK6_RS08265	COG3708	Transcriptional regulator
NK6_RS08270	COG4948	Mandelate Racemase Muconate Lactonizing
NK6_RS08310	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
NK6_RS08310	COG1672	PFAM Archaeal ATPase
NK6_RS08325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NK6_RS08330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NK6_RS08335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NK6_RS08340	COG0601	transmembrane transport
NK6_RS08345	COG0747	negative chemotaxis
NK6_RS08355	COG0784	Response regulator, receiver
NK6_RS08355	COG4191	Histidine kinase
NK6_RS08370	COG1231	oxidoreductase activity
NK6_RS08425	COG4948	Mandelate Racemase Muconate Lactonizing
NK6_RS08435	COG0386	Belongs to the glutathione peroxidase family
NK6_RS08440	COG0154	amidase activity
NK6_RS08455	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NK6_RS08460	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
NK6_RS08465	COG0535	radical SAM domain protein
NK6_RS08470	COG0535	radical SAM domain protein
NK6_RS08485	COG0493	'glutamate synthase
NK6_RS08490	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NK6_RS08490	COG0674	pyruvate-flavodoxin oxidoreductase activity
NK6_RS08495	COG1013	pyruvate-flavodoxin oxidoreductase activity
NK6_RS08545	COG2719	SpoVR family
NK6_RS08550	COG2718	Belongs to the UPF0229 family
NK6_RS08555	COG2766	serine protein kinase
NK6_RS08570	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NK6_RS08575	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NK6_RS08580	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NK6_RS08585	COG0363	glucosamine-6-phosphate deaminase activity
NK6_RS08590	COG3265	gluconokinase activity
NK6_RS08600	COG3387	PFAM Glycoside hydrolase 15-related
NK6_RS08605	COG1640	4-alpha-glucanotransferase
NK6_RS08610	COG0366	Alpha amylase catalytic
NK6_RS08615	COG0366	Alpha amylase catalytic
NK6_RS08620	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NK6_RS08630	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NK6_RS08650	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NK6_RS08655	COG0745	RESPONSE REGULATOR receiver
NK6_RS08660	COG2205	protein histidine kinase activity
NK6_RS08670	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
NK6_RS08675	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
NK6_RS08680	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NK6_RS08705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NK6_RS08725	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NK6_RS08730	COG0318	PFAM AMP-dependent synthetase and ligase
NK6_RS08770	COG2030	dehydratase
NK6_RS08805	COG0477	Major facilitator Superfamily
NK6_RS08820	COG1053	succinate dehydrogenase
NK6_RS08825	COG1414	Transcriptional regulator
NK6_RS08830	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS08835	COG0028	Belongs to the TPP enzyme family
NK6_RS08835	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
NK6_RS08865	COG0028	Belongs to the TPP enzyme family
NK6_RS08870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NK6_RS08890	COG2272	Belongs to the type-B carboxylesterase lipase family
NK6_RS08895	COG0477	Major facilitator Superfamily
NK6_RS08900	COG1309	transcriptional regulator
NK6_RS08910	COG1176	ABC-type spermidine putrescine transport system, permease component I
NK6_RS08920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NK6_RS08930	COG3842	ATPase activity
NK6_RS08935	COG0583	DNA-binding transcription factor activity
NK6_RS08945	COG1063	alcohol dehydrogenase
NK6_RS08950	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NK6_RS08960	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NK6_RS08970	COG0246	Mannitol dehydrogenase
NK6_RS08995	COG0412	Dienelactone hydrolase
NK6_RS09050	COG0411	ABC transporter
NK6_RS09055	COG0559	Belongs to the binding-protein-dependent transport system permease family
NK6_RS09060	COG0683	leucine binding
NK6_RS09075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NK6_RS09080	COG1464	Belongs to the NlpA lipoprotein family
NK6_RS09090	COG1309	transcriptional regulator
NK6_RS09095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NK6_RS09125	COG1126	abc transporter atp-binding protein
NK6_RS09135	COG0765	amino acid transport
NK6_RS09145	COG0673	inositol 2-dehydrogenase activity
NK6_RS09165	COG1595	DNA-templated transcription, initiation
NK6_RS09175	COG0477	Major facilitator Superfamily
NK6_RS09190	COG4191	Histidine kinase
NK6_RS09190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NK6_RS09195	COG2204	response regulator
NK6_RS09200	COG1024	Enoyl-CoA hydratase
NK6_RS09200	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NK6_RS09205	COG0309	Hydrogenase expression formation protein (HypE)
NK6_RS09210	COG0409	Hydrogenase expression formation protein
NK6_RS09225	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NK6_RS09230	COG0375	protein maturation
NK6_RS09235	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
NK6_RS09240	COG1773	rubredoxin
NK6_RS09245	COG1773	rubredoxin
NK6_RS09250	COG1773	rubredoxin
NK6_RS09255	COG3118	belongs to the thioredoxin family
NK6_RS09260	COG0298	carbon dioxide binding
NK6_RS09265	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
NK6_RS09270	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
NK6_RS09275	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
NK6_RS09320	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
NK6_RS09330	COG4584	PFAM Integrase catalytic
NK6_RS09360	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS09365	COG4372	Transposase
NK6_RS09375	COG2801	Transposase and inactivated derivatives
NK6_RS09430	COG0459	protein refolding
NK6_RS09435	COG3344	reverse transcriptase
NK6_RS09530	COG2801	Transposase and inactivated derivatives
NK6_RS09570	COG4191	Histidine kinase
NK6_RS09595	COG1335	isochorismatase
NK6_RS09630	COG2197	response regulator
NK6_RS09640	COG0861	Integral membrane protein TerC family
NK6_RS09655	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NK6_RS09685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NK6_RS09700	COG0482	sulfurtransferase activity
NK6_RS09710	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
NK6_RS09720	COG1766	The M ring may be actively involved in energy transduction
NK6_RS09725	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NK6_RS09735	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NK6_RS09740	COG2204	response regulator
NK6_RS09760	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NK6_RS09765	COG1116	anion transmembrane transporter activity
NK6_RS09770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NK6_RS09775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NK6_RS09780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NK6_RS09850	COG0583	DNA-binding transcription factor activity
NK6_RS09865	COG1280	lysine exporter protein (LysE YggA)
NK6_RS09875	COG2010	Cytochrome c
NK6_RS09885	COG0071	Belongs to the small heat shock protein (HSP20) family
NK6_RS09900	COG0070	glutamate synthase
NK6_RS09900	COG0069	glutamate synthase activity
NK6_RS09900	COG0067	glutamate synthase
NK6_RS09935	COG0330	HflC and HflK could
NK6_RS09945	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NK6_RS09955	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
NK6_RS09985	COG0251	oxidation-reduction process
NK6_RS09995	COG4689	acetoacetate decarboxylase
NK6_RS10015	COG0523	cobalamin synthesis protein
NK6_RS10020	COG0803	Belongs to the bacterial solute-binding protein 9 family
NK6_RS10025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NK6_RS10030	COG1121	(ABC) transporter
NK6_RS10050	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NK6_RS10085	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS10105	COG0318	PFAM AMP-dependent synthetase and ligase
NK6_RS10130	COG0326	Molecular chaperone. Has ATPase activity
NK6_RS10160	COG3547	Transposase (IS116 IS110 IS902 family)
NK6_RS10170	COG0784	Response regulator, receiver
NK6_RS10185	COG0778	Nitroreductase
NK6_RS10190	COG1960	acyl-CoA dehydrogenase activity
NK6_RS10195	COG1960	acyl-CoA dehydrogenase activity
NK6_RS10200	COG1960	acyl-CoA dehydrogenase activity
NK6_RS10205	COG0318	PFAM AMP-dependent synthetase and ligase
NK6_RS10250	COG2267	carboxylic ester hydrolase activity
NK6_RS10290	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
NK6_RS10300	COG1960	acyl-CoA dehydrogenase activity
NK6_RS10305	COG0183	Belongs to the thiolase family
NK6_RS10310	COG0318	PFAM AMP-dependent synthetase and ligase
NK6_RS10335	COG0559	Belongs to the binding-protein-dependent transport system permease family
NK6_RS10390	COG0583	DNA-binding transcription factor activity
NK6_RS10415	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NK6_RS10430	COG1024	Enoyl-CoA hydratase
NK6_RS10435	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS10435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NK6_RS10435	COG0318	PFAM AMP-dependent synthetase and ligase
NK6_RS10435	COG0300	oxidoreductase activity
NK6_RS10435	COG3321	synthase
NK6_RS10495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NK6_RS10500	COG1024	Enoyl-CoA hydratase
NK6_RS10515	COG2378	regulation of single-species biofilm formation
NK6_RS10530	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NK6_RS10535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NK6_RS10540	COG0318	PFAM AMP-dependent synthetase and ligase
NK6_RS10555	COG1172	Belongs to the binding-protein-dependent transport system permease family
NK6_RS10560	COG1879	ABC-type sugar transport system periplasmic component
NK6_RS10580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NK6_RS10585	COG1129	ABC transporter
NK6_RS10585	COG0842	Transport permease protein
NK6_RS10590	COG0842	Transport permease protein
NK6_RS10625	COG0656	L-ascorbic acid biosynthetic process
NK6_RS10635	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS10640	COG0640	Transcriptional regulator
NK6_RS10670	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS10680	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS10695	COG0179	Fumarylacetoacetate (FAA) hydrolase
NK6_RS10710	COG2267	carboxylic ester hydrolase activity
NK6_RS10730	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
NK6_RS10735	COG1960	acyl-CoA dehydrogenase activity
NK6_RS10740	COG4221	oxidoreductase activity
NK6_RS10745	COG1024	Enoyl-CoA hydratase
NK6_RS10760	COG0583	DNA-binding transcription factor activity
NK6_RS10800	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NK6_RS10805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NK6_RS10810	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
NK6_RS10825	COG0154	amidase activity
NK6_RS10835	COG4608	Belongs to the ABC transporter superfamily
NK6_RS10845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NK6_RS10855	COG0747	negative chemotaxis
NK6_RS10860	COG0747	negative chemotaxis
NK6_RS10895	COG1022	Amp-dependent synthetase and ligase
NK6_RS10960	COG2309	aminopeptidase activity
NK6_RS10965	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NK6_RS10990	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
NK6_RS11005	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
NK6_RS11030	COG1024	Enoyl-CoA hydratase
NK6_RS11040	COG1309	transcriptional regulator
NK6_RS11060	COG0071	Belongs to the small heat shock protein (HSP20) family
NK6_RS11065	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
NK6_RS11070	COG2610	gluconate transmembrane transporter activity
NK6_RS11080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NK6_RS11095	COG4774	siderophore transport
NK6_RS11100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NK6_RS11105	COG0277	FAD linked oxidase domain protein
NK6_RS11110	COG1802	Transcriptional regulator
NK6_RS11115	COG1032	radical SAM domain protein
NK6_RS11120	COG1959	2 iron, 2 sulfur cluster binding
NK6_RS11140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NK6_RS11155	COG2264	protein methyltransferase activity
NK6_RS11190	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
NK6_RS11220	COG2902	Dehydrogenase
NK6_RS11245	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NK6_RS11285	COG4584	PFAM Integrase catalytic
NK6_RS11325	COG3328	transposase activity
NK6_RS11330	COG4584	PFAM Integrase catalytic
NK6_RS11335	COG4372	Transposase
NK6_RS11380	COG2801	Transposase and inactivated derivatives
NK6_RS11405	COG1657	PFAM Prenyltransferase squalene oxidase
NK6_RS11415	COG0142	geranyltranstransferase activity
NK6_RS11420	COG2124	cytochrome p450
NK6_RS11425	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS11435	COG2124	cytochrome p450
NK6_RS11440	COG2124	cytochrome p450
NK6_RS11485	COG3344	reverse transcriptase
NK6_RS11495	COG3344	reverse transcriptase
NK6_RS11520	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NK6_RS11540	COG1943	Transposase
NK6_RS11545	COG0583	DNA-binding transcription factor activity
NK6_RS11560	COG0655	NAD(P)H dehydrogenase (quinone) activity
NK6_RS11565	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NK6_RS11585	COG1215	transferase activity, transferring glycosyl groups
NK6_RS11610	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NK6_RS11625	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
NK6_RS11635	COG0179	Fumarylacetoacetate (FAA) hydrolase
NK6_RS11670	COG0583	DNA-binding transcription factor activity
NK6_RS11685	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NK6_RS11695	COG1126	abc transporter atp-binding protein
NK6_RS11700	COG0765	amino acid transport
NK6_RS11705	COG0765	amino acid transport
NK6_RS11740	COG1902	pentaerythritol trinitrate reductase activity
NK6_RS11745	COG1012	belongs to the aldehyde dehydrogenase family
NK6_RS11760	COG2146	nitrite reductase [NAD(P)H] activity
NK6_RS11795	COG4166	transmembrane transport
NK6_RS11800	COG1472	Belongs to the glycosyl hydrolase 3 family
NK6_RS11810	COG0745	RESPONSE REGULATOR receiver
NK6_RS11815	COG2205	protein histidine kinase activity
NK6_RS11855	COG0826	peptidase U32
NK6_RS11900	COG1082	Xylose isomerase domain protein TIM barrel
NK6_RS11905	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
NK6_RS11935	COG4297	protein containing double-stranded beta helix domain
NK6_RS11940	COG0671	phosphoesterase, PA-phosphatase related
NK6_RS11995	COG0438	transferase activity, transferring glycosyl groups
NK6_RS12020	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NK6_RS12025	COG3685	Protein conserved in bacteria
NK6_RS12030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NK6_RS12030	COG0723	plastoquinol--plastocyanin reductase activity
NK6_RS12060	COG0693	protein deglycase activity
NK6_RS12070	COG0546	phosphoglycolate phosphatase activity
NK6_RS12165	COG3344	reverse transcriptase
NK6_RS12195	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS12200	COG4372	Transposase
NK6_RS12215	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NK6_RS12230	COG2801	Transposase and inactivated derivatives
NK6_RS12255	COG4584	PFAM Integrase catalytic
NK6_RS12260	COG1484	DNA-dependent DNA replication
NK6_RS12270	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS12275	COG4974	Belongs to the 'phage' integrase family
NK6_RS12285	COG4584	PFAM Integrase catalytic
NK6_RS12290	COG4372	Transposase
NK6_RS12295	COG2801	Transposase and inactivated derivatives
NK6_RS12305	COG3547	Transposase (IS116 IS110 IS902 family)
NK6_RS12325	COG3436	PFAM IS66 Orf2 family protein
NK6_RS12330	COG2963	transposase activity
NK6_RS12335	COG0459	protein refolding
NK6_RS12340	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NK6_RS12345	COG0275	rRNA processing
NK6_RS12370	COG4372	Transposase
NK6_RS12375	COG4372	Transposase
NK6_RS12380	COG4584	PFAM Integrase catalytic
NK6_RS12390	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS12420	COG1278	Cold shock
NK6_RS12425	COG1505	serine-type exopeptidase activity
NK6_RS12435	COG3293	Transposase
NK6_RS12440	COG3344	reverse transcriptase
NK6_RS12445	COG3547	Transposase (IS116 IS110 IS902 family)
NK6_RS12550	COG4372	Transposase
NK6_RS12565	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
NK6_RS12580	COG4750	Nucleotidyl transferase
NK6_RS12605	COG4886	Leucine-rich repeat (LRR) protein
NK6_RS12610	COG4886	Leucine-rich repeat (LRR) protein
NK6_RS12625	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NK6_RS12625	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NK6_RS12650	COG2801	Transposase and inactivated derivatives
NK6_RS12690	COG0745	RESPONSE REGULATOR receiver
NK6_RS12695	COG4964	Belongs to the GSP D family
NK6_RS12730	COG2801	Transposase and inactivated derivatives
NK6_RS12785	COG4792	protein secretion
NK6_RS12790	COG4791	protein targeting
NK6_RS12795	COG4794	Type iii secretion
NK6_RS12800	COG4790	Type iii secretion
NK6_RS12805	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NK6_RS12815	COG1157	protein secretion by the type III secretion system
NK6_RS12820	COG1317	bacterial-type flagellum organization
NK6_RS12830	COG4669	(LipO)protein
NK6_RS12850	COG4584	PFAM Integrase catalytic
NK6_RS12890	COG4789	Type iii secretion
NK6_RS12900	COG2801	Transposase and inactivated derivatives
NK6_RS12910	COG0612	Peptidase, M16
NK6_RS12950	COG4886	Leucine-rich repeat (LRR) protein
NK6_RS12975	COG0535	radical SAM domain protein
NK6_RS12980	COG5554	nitrogen fixation
NK6_RS13000	COG3047	cAMP biosynthetic process
NK6_RS13005	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
NK6_RS13020	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NK6_RS13025	COG0644	oxidoreductase
NK6_RS13030	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
NK6_RS13035	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NK6_RS13065	COG1408	metallophosphoesterase
NK6_RS13075	COG2255	four-way junction helicase activity
NK6_RS13080	COG0632	four-way junction helicase activity
NK6_RS13085	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NK6_RS13090	COG0217	transcriptional regulatory protein
NK6_RS13125	COG1692	metallophosphoesterase
NK6_RS13160	COG0126	phosphoglycerate kinase activity
NK6_RS13170	COG3588	fructose-bisphosphate aldolase
NK6_RS13185	COG0483	inositol monophosphate 1-phosphatase activity
NK6_RS13190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NK6_RS13195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NK6_RS13205	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NK6_RS13225	COG1132	(ABC) transporter
NK6_RS13230	COG0254	rRNA binding
NK6_RS13245	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS13245	COG0604	alcohol dehydrogenase
NK6_RS13245	COG3321	synthase
NK6_RS13260	COG5001	Diguanylate cyclase
NK6_RS13260	COG2203	Gaf domain
NK6_RS13260	COG3706	GGDEF domain
NK6_RS13260	COG4251	negative regulation of phosphorylation
NK6_RS13270	COG2951	lytic endotransglycosylase activity
NK6_RS13280	COG3237	CsbD-like
NK6_RS13285	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS13290	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS13300	COG1678	Uncharacterized ACR, COG1678
NK6_RS13315	COG0730	response to heat
NK6_RS13320	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS13340	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NK6_RS13345	COG4208	sulfate ABC transporter
NK6_RS13350	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NK6_RS13355	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
NK6_RS13360	COG0175	sulfate reduction
NK6_RS13370	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NK6_RS13380	COG1648	precorrin-2 dehydrogenase activity
NK6_RS13380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NK6_RS13395	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NK6_RS13400	COG3237	CsbD-like
NK6_RS13420	COG1376	ErfK ybiS ycfS ynhG family protein
NK6_RS13420	COG1388	LysM domain
NK6_RS13425	COG0628	permease
NK6_RS13460	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NK6_RS13465	COG0830	nickel cation binding
NK6_RS13480	COG0804	urea catabolic process
NK6_RS13485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NK6_RS13490	COG0832	Belongs to the urease beta subunit family
NK6_RS13495	COG0831	urea catabolic process
NK6_RS13500	COG0829	nickel cation binding
NK6_RS13530	COG0513	Belongs to the DEAD box helicase family
NK6_RS13535	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NK6_RS13540	COG1278	Cold shock
NK6_RS13570	COG4964	Belongs to the GSP D family
NK6_RS13610	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NK6_RS13615	COG0791	NLP P60 protein
NK6_RS13640	COG4172	Belongs to the ABC transporter superfamily
NK6_RS13645	COG4239	(ABC) transporter, permease
NK6_RS13650	COG4174	ABC transporter (Permease)
NK6_RS13655	COG4166	transmembrane transport
NK6_RS13660	COG4166	transmembrane transport
NK6_RS13665	COG3474	cytochrome
NK6_RS13670	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
NK6_RS13675	COG0077	Prephenate dehydratase
NK6_RS13675	COG1605	Chorismate mutase
NK6_RS13680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NK6_RS13710	COG0640	Transcriptional regulator
NK6_RS13715	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NK6_RS13730	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NK6_RS13765	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS13810	COG2801	Transposase and inactivated derivatives
NK6_RS13835	COG3328	transposase activity
NK6_RS13840	COG2801	Transposase and inactivated derivatives
NK6_RS13845	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS13850	COG4372	Transposase
NK6_RS13855	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS13900	COG2433	Pfam Transposase IS66
NK6_RS13915	COG3344	reverse transcriptase
NK6_RS13950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NK6_RS13990	COG1181	Belongs to the D-alanine--D-alanine ligase family
NK6_RS14000	COG0405	Gamma-glutamyltransferase
NK6_RS14005	COG1509	lysine 2,3-aminomutase activity
NK6_RS14020	COG4372	Transposase
NK6_RS14035	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS14055	COG3831	ATPase activity
NK6_RS14115	COG2801	Transposase and inactivated derivatives
NK6_RS14195	COG3547	Transposase (IS116 IS110 IS902 family)
NK6_RS14200	COG4584	PFAM Integrase catalytic
NK6_RS14295	COG4886	Leucine-rich repeat (LRR) protein
NK6_RS14325	COG2801	Transposase and inactivated derivatives
NK6_RS14380	COG2814	Major facilitator Superfamily
NK6_RS14390	COG5554	nitrogen fixation
NK6_RS14395	COG1104	cysteine desulfurase activity
NK6_RS14400	COG0316	Belongs to the HesB IscA family
NK6_RS14420	COG4584	PFAM Integrase catalytic
NK6_RS14440	COG5420	small protein containing a coiled-coil domain
NK6_RS14455	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
NK6_RS14460	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
NK6_RS14465	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
NK6_RS14470	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
NK6_RS14495	COG0396	ATPase activity
NK6_RS14505	COG0686	Belongs to the AlaDH PNT family
NK6_RS14540	COG0582	viral genome integration into host DNA
NK6_RS14615	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS14645	COG4372	Transposase
NK6_RS14650	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS14670	COG4372	Transposase
NK6_RS14680	COG0582	viral genome integration into host DNA
NK6_RS14700	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
NK6_RS14720	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
NK6_RS14730	COG1301	dicarboxylic acid transport
NK6_RS14745	COG4191	Histidine kinase
NK6_RS14750	COG4566	intracellular signal transduction
NK6_RS14755	COG4566	intracellular signal transduction
NK6_RS14770	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS14790	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS14815	COG3547	Transposase (IS116 IS110 IS902 family)
NK6_RS14885	COG3047	cAMP biosynthetic process
NK6_RS14900	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NK6_RS14905	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NK6_RS14910	COG0328	RNA-DNA hybrid ribonuclease activity
NK6_RS14915	COG0678	peroxiredoxin activity
NK6_RS14915	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NK6_RS14925	COG0318	PFAM AMP-dependent synthetase and ligase
NK6_RS14930	COG1686	Belongs to the peptidase S11 family
NK6_RS14935	COG1132	(ABC) transporter
NK6_RS14950	COG0140	phosphoribosyl-ATP diphosphatase activity
NK6_RS14955	COG1238	metal cluster binding
NK6_RS14965	COG1027	Aspartate ammonia-lyase
NK6_RS14990	COG2070	2-Nitropropane dioxygenase
NK6_RS15015	COG4585	Histidine kinase
NK6_RS15095	COG0667	Aldo Keto reductase
NK6_RS15120	COG4191	Histidine kinase
NK6_RS15125	COG4716	Myosin-crossreactive antigen
NK6_RS15130	COG1022	Amp-dependent synthetase and ligase
NK6_RS15140	COG1335	isochorismatase
NK6_RS15170	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NK6_RS15175	COG2186	Transcriptional regulator
NK6_RS15195	COG3052	prosthetic group binding
NK6_RS15215	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
NK6_RS15230	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
NK6_RS15235	COG0424	maF-like protein
NK6_RS15240	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NK6_RS15245	COG5328	Belongs to the UPF0262 family
NK6_RS15250	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NK6_RS15260	COG0702	epimerase
NK6_RS15305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NK6_RS15320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NK6_RS15325	COG2197	response regulator
NK6_RS15340	COG3971	2-oxopent-4-enoate hydratase activity
NK6_RS15345	COG0179	Fumarylacetoacetate (FAA) hydrolase
NK6_RS15355	COG3181	Tripartite tricarboxylate transporter family receptor
NK6_RS15375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NK6_RS15395	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
NK6_RS15400	COG3454	Phosphonate metabolism
NK6_RS15405	COG4778	phosphonate C-P lyase system protein PhnL
NK6_RS15410	COG4107	phosphonate C-P lyase system protein PhnK
NK6_RS15415	COG3627	carbon phosphorus lyase activity
NK6_RS15425	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
NK6_RS15430	COG3624	Phosphonate C-P lyase system protein PhnG
NK6_RS15435	COG2188	Transcriptional regulator
NK6_RS15440	COG2020	methyltransferase activity
NK6_RS15485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NK6_RS15530	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NK6_RS15535	COG0156	8-amino-7-oxononanoate synthase activity
NK6_RS15540	COG0784	Response regulator, receiver
NK6_RS15540	COG2205	protein histidine kinase activity
NK6_RS15550	COG0596	Alpha beta hydrolase
NK6_RS15555	COG1764	response to oxidative stress
NK6_RS15580	COG0432	Pfam Uncharacterised protein family UPF0047
NK6_RS15595	COG0356	it plays a direct role in the translocation of protons across the membrane
NK6_RS15605	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NK6_RS15610	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NK6_RS15620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NK6_RS15625	COG0612	Peptidase, M16
NK6_RS15650	COG3346	SURF1 family
NK6_RS15665	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
NK6_RS15675	COG0109	protoheme IX farnesyltransferase activity
NK6_RS15680	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NK6_RS15685	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NK6_RS15695	COG0312	modulator of DNA gyrase
NK6_RS15700	COG0681	Belongs to the peptidase S26 family
NK6_RS15725	COG0625	glutathione transferase activity
NK6_RS15740	COG1024	Enoyl-CoA hydratase
NK6_RS15740	COG1250	3-hydroxyacyl-CoA dehydrogenase
NK6_RS15745	COG0183	Belongs to the thiolase family
NK6_RS15750	COG1960	acyl-CoA dehydrogenase activity
NK6_RS15760	COG1695	Transcriptional regulator
NK6_RS15770	COG0730	response to heat
NK6_RS15790	COG0583	DNA-binding transcription factor activity
NK6_RS15800	COG1201	RNA secondary structure unwinding
NK6_RS15830	COG1234	tRNA 3'-trailer cleavage
NK6_RS15840	COG0167	dihydroorotate dehydrogenase activity
NK6_RS15875	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
NK6_RS15885	COG1999	signal sequence binding
NK6_RS15910	COG0251	oxidation-reduction process
NK6_RS15940	COG1172	Belongs to the binding-protein-dependent transport system permease family
NK6_RS15945	COG1129	ABC transporter
NK6_RS15950	COG2115	Belongs to the xylose isomerase family
NK6_RS15955	COG1070	Carbohydrate kinase
NK6_RS15975	COG1396	sequence-specific DNA binding
NK6_RS15985	COG2267	carboxylic ester hydrolase activity
NK6_RS16010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NK6_RS16050	COG0717	Belongs to the dCTP deaminase family
NK6_RS16075	COG2967	ApaG domain
NK6_RS16085	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NK6_RS16090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NK6_RS16100	COG0745	RESPONSE REGULATOR receiver
NK6_RS16105	COG0704	Plays a role in the regulation of phosphate uptake
NK6_RS16110	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NK6_RS16115	COG0581	inorganic phosphate transmembrane transporter activity
NK6_RS16120	COG0573	inorganic phosphate transmembrane transporter activity
NK6_RS16130	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NK6_RS16135	COG5002	protein histidine kinase activity
NK6_RS16155	COG0596	Alpha beta hydrolase
NK6_RS16170	COG2885	chlorophyll binding
NK6_RS16170	COG3047	cAMP biosynthetic process
NK6_RS16180	COG4584	PFAM Integrase catalytic
NK6_RS16215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NK6_RS16220	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NK6_RS16240	COG4372	Transposase
NK6_RS16245	COG4372	Transposase
NK6_RS16270	COG1414	Transcriptional regulator
NK6_RS16275	COG4638	Rieske (2fe-2S)
NK6_RS16315	COG3916	Acyl-homoserine-lactone synthase
NK6_RS16320	COG2197	response regulator
NK6_RS16325	COG0583	DNA-binding transcription factor activity
NK6_RS16330	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NK6_RS16345	COG4177	L-phenylalanine transmembrane transporter activity
NK6_RS16370	COG1252	NADH dehydrogenase
NK6_RS16385	COG2124	cytochrome p450
NK6_RS16395	COG0318	PFAM AMP-dependent synthetase and ligase
NK6_RS16410	COG1802	Transcriptional regulator
NK6_RS16430	COG4172	Belongs to the ABC transporter superfamily
NK6_RS16435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NK6_RS16440	COG0601	transmembrane transport
NK6_RS16445	COG0747	negative chemotaxis
NK6_RS16465	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS16475	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NK6_RS16480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NK6_RS16480	COG4191	Histidine kinase
NK6_RS16485	COG3437	response regulator, receiver
NK6_RS16485	COG0784	Response regulator, receiver
NK6_RS16495	COG1595	DNA-templated transcription, initiation
NK6_RS16520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NK6_RS16525	COG1960	acyl-CoA dehydrogenase activity
NK6_RS16530	COG1960	acyl-CoA dehydrogenase activity
NK6_RS16540	COG2514	catechol 2,3-dioxygenase activity
NK6_RS16550	COG2814	Major facilitator Superfamily
NK6_RS16555	COG1505	serine-type exopeptidase activity
NK6_RS16565	COG4654	Cytochrome c, class I
NK6_RS16590	COG0737	Belongs to the 5'-nucleotidase family
NK6_RS16610	COG2271	Major facilitator Superfamily
NK6_RS16640	COG3788	relative of glutathione S-transferase, MAPEG superfamily
NK6_RS16645	COG0683	leucine binding
NK6_RS16675	COG0601	transmembrane transport
NK6_RS16680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NK6_RS16685	COG0444	Belongs to the ABC transporter superfamily
NK6_RS16690	COG4608	Belongs to the ABC transporter superfamily
NK6_RS16710	COG0439	Biotin carboxylase
NK6_RS16715	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NK6_RS16720	COG1960	acyl-CoA dehydrogenase activity
NK6_RS16770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NK6_RS16810	COG0784	Response regulator, receiver
NK6_RS16810	COG5002	protein histidine kinase activity
NK6_RS16810	COG2198	Histidine kinase
NK6_RS16815	COG0745	RESPONSE REGULATOR receiver
NK6_RS16820	COG2072	flavoprotein involved in K transport
NK6_RS16835	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NK6_RS16840	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NK6_RS16845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NK6_RS16855	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NK6_RS16890	COG3300	MHYT domain
NK6_RS16890	COG5001	Diguanylate cyclase
NK6_RS16905	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NK6_RS16910	COG0142	geranyltranstransferase activity
NK6_RS16950	COG0025	NhaP-type Na H and K H
NK6_RS16965	COG2175	clavaminate synthase activity
NK6_RS16970	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NK6_RS16990	COG1566	PFAM secretion protein HlyD family protein
NK6_RS16995	COG2814	Major facilitator Superfamily
NK6_RS17010	COG3485	protocatechuate 3,4-dioxygenase
NK6_RS17015	COG3485	protocatechuate 3,4-dioxygenase
NK6_RS17020	COG3485	protocatechuate 3,4-dioxygenase
NK6_RS17025	COG0183	Belongs to the thiolase family
NK6_RS17030	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NK6_RS17055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NK6_RS17095	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NK6_RS17120	COG1131	(ABC) transporter
NK6_RS17130	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
NK6_RS17145	COG0366	Alpha amylase catalytic
NK6_RS17150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NK6_RS17160	COG0477	Major facilitator Superfamily
NK6_RS17180	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS17190	COG5001	Diguanylate cyclase
NK6_RS17215	COG0411	ABC transporter
NK6_RS17235	COG5001	Diguanylate cyclase
NK6_RS17265	COG4372	Transposase
NK6_RS17335	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NK6_RS17350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NK6_RS17390	COG0318	PFAM AMP-dependent synthetase and ligase
NK6_RS17415	COG0412	Dienelactone hydrolase
NK6_RS17430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NK6_RS17440	COG0268	Binds directly to 16S ribosomal RNA
NK6_RS17445	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NK6_RS17455	COG2852	Protein conserved in bacteria
NK6_RS17460	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NK6_RS17490	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NK6_RS17495	COG0534	Mate efflux family protein
NK6_RS17535	COG1741	Belongs to the pirin family
NK6_RS17565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NK6_RS17575	COG0180	Tryptophanyl-tRNA synthetase
NK6_RS17605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NK6_RS17615	COG1702	phosphate starvation-inducible protein PhoH
NK6_RS17620	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NK6_RS17625	COG1253	flavin adenine dinucleotide binding
NK6_RS17630	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NK6_RS17635	COG1396	sequence-specific DNA binding
NK6_RS17645	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NK6_RS17655	COG0779	Required for maturation of 30S ribosomal subunits
NK6_RS17675	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NK6_RS17680	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NK6_RS17685	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NK6_RS17690	COG1185	polyribonucleotide nucleotidyltransferase activity
NK6_RS17695	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
NK6_RS17730	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NK6_RS17740	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NK6_RS17760	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NK6_RS17775	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NK6_RS17780	COG2226	methyltransferase
NK6_RS17785	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NK6_RS17790	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NK6_RS17795	COG0756	dUTP diphosphatase activity
NK6_RS17800	COG2205	protein histidine kinase activity
NK6_RS17805	COG3178	'Phosphotransferase
NK6_RS17815	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NK6_RS17825	COG1074	ATP-dependent DNA helicase activity
NK6_RS17840	COG0285	dihydrofolate synthase activity
NK6_RS17845	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NK6_RS17850	COG0159	tryptophan synthase activity
NK6_RS17855	COG0133	tryptophan synthase activity
NK6_RS17860	COG0135	phosphoribosylanthranilate isomerase activity
NK6_RS17870	COG0776	regulation of translation
NK6_RS17875	COG0616	signal peptide processing
NK6_RS17880	COG0539	negative regulation of cytoplasmic translation
NK6_RS17885	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NK6_RS17890	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NK6_RS17905	COG1846	Transcriptional regulator
NK6_RS17910	COG1764	response to oxidative stress
NK6_RS17930	COG0395	ABC-type sugar transport system, permease component
NK6_RS17935	COG3842	ATPase activity
NK6_RS17940	COG0071	Belongs to the small heat shock protein (HSP20) family
NK6_RS17960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NK6_RS17965	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NK6_RS17970	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
NK6_RS17975	COG1137	ATPase activity
NK6_RS17980	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
NK6_RS17995	COG2814	Major facilitator Superfamily
NK6_RS18010	COG1968	undecaprenyl-diphosphatase activity
NK6_RS18020	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NK6_RS18040	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NK6_RS18050	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NK6_RS18055	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NK6_RS18065	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NK6_RS18090	COG1937	Protein conserved in bacteria
NK6_RS18105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NK6_RS18110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NK6_RS18120	COG2814	Major facilitator Superfamily
NK6_RS18160	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NK6_RS18165	COG0588	phosphoglycerate mutase activity
NK6_RS18170	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NK6_RS18180	COG0284	orotidine-5'-phosphate decarboxylase activity
NK6_RS18185	COG0431	NADPH-dependent FMN reductase
NK6_RS18190	COG3963	phosphatidate phosphatase activity
NK6_RS18195	COG0484	heat shock protein binding
NK6_RS18200	COG0443	Heat shock 70 kDa protein
NK6_RS18210	COG1335	isochorismatase
NK6_RS18215	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NK6_RS18220	COG1420	regulation of RNA biosynthetic process
NK6_RS18225	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NK6_RS18230	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NK6_RS18235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NK6_RS18245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NK6_RS18250	COG0792	nuclease activity
NK6_RS18255	COG0189	ligase activity
NK6_RS18265	COG0606	chelatase, subunit chli
NK6_RS18275	COG0784	Response regulator, receiver
NK6_RS18275	COG2205	protein histidine kinase activity
NK6_RS18275	COG5002	protein histidine kinase activity
NK6_RS18285	COG0628	permease
NK6_RS18290	COG1072	(Pantothenic acid kinase))
NK6_RS18295	COG0140	phosphoribosyl-ATP diphosphatase activity
NK6_RS18300	COG0107	imidazoleglycerol-phosphate synthase activity
NK6_RS18305	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NK6_RS18310	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NK6_RS18320	COG0131	Imidazoleglycerol-phosphate dehydratase
NK6_RS18325	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NK6_RS18340	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NK6_RS18355	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
NK6_RS18365	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
NK6_RS18370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NK6_RS18375	COG0237	dephospho-CoA kinase activity
NK6_RS18380	COG0424	maF-like protein
NK6_RS18385	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NK6_RS18390	COG1981	membrane
NK6_RS18395	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NK6_RS18405	COG0445	tRNA wobble uridine modification
NK6_RS18410	COG0357	Ribosomal RNA small subunit methyltransferase G
NK6_RS18435	COG0495	leucyl-tRNA aminoacylation
NK6_RS18450	COG3706	GGDEF domain
NK6_RS18450	COG2203	Gaf domain
NK6_RS18450	COG5001	Diguanylate cyclase
NK6_RS18450	COG4251	negative regulation of phosphorylation
NK6_RS18470	COG0745	RESPONSE REGULATOR receiver
NK6_RS18485	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NK6_RS18490	COG1674	ftsk spoiiie
NK6_RS18495	COG0436	Aminotransferase
NK6_RS18505	COG0004	ammonium transporteR
NK6_RS18510	COG0347	Belongs to the P(II) protein family
NK6_RS18520	COG4584	PFAM Integrase catalytic
NK6_RS18525	COG0740	serine-type endopeptidase activity
NK6_RS18535	COG0640	Transcriptional regulator
NK6_RS18540	COG0004	ammonium transporteR
NK6_RS18545	COG0347	Belongs to the P(II) protein family
NK6_RS18555	COG1946	Acyl-CoA thioesterase
NK6_RS18560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NK6_RS18565	COG2835	tetraacyldisaccharide 4'-kinase activity
NK6_RS18605	COG3118	belongs to the thioredoxin family
NK6_RS18615	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
NK6_RS18640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NK6_RS18655	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NK6_RS18665	COG0534	Mate efflux family protein
NK6_RS18680	COG2814	Major facilitator Superfamily
NK6_RS18685	COG0405	Gamma-glutamyltransferase
NK6_RS18695	COG0138	bifunctional purine biosynthesis protein purh
NK6_RS18715	COG4529	Protein conserved in bacteria
NK6_RS18735	COG1376	ErfK ybiS ycfS ynhG family protein
NK6_RS18740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NK6_RS18755	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
NK6_RS18765	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NK6_RS18770	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NK6_RS18810	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NK6_RS18855	COG3547	Transposase (IS116 IS110 IS902 family)
NK6_RS18895	COG4584	PFAM Integrase catalytic
NK6_RS18935	COG2814	Major facilitator Superfamily
NK6_RS18960	COG4221	oxidoreductase activity
NK6_RS18970	COG1024	Enoyl-CoA hydratase
NK6_RS18990	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NK6_RS18995	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NK6_RS19000	COG1247	-acetyltransferase
NK6_RS19020	COG3011	Protein conserved in bacteria
NK6_RS19030	COG1217	gtp-binding protein TYPA
NK6_RS19060	COG0784	Response regulator, receiver
NK6_RS19075	COG2154	pterin-4-alpha-carbinolamine dehydratase
NK6_RS19095	COG0604	alcohol dehydrogenase
NK6_RS19095	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS19095	COG3321	synthase
NK6_RS19100	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS19110	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NK6_RS19120	COG0671	phosphoesterase, PA-phosphatase related
NK6_RS19125	COG0137	argininosuccinate synthase activity
NK6_RS19150	COG4178	(ABC) transporter
NK6_RS19155	COG0784	Response regulator, receiver
NK6_RS19155	COG4191	Histidine kinase
NK6_RS19180	COG0583	DNA-binding transcription factor activity
NK6_RS19185	COG0730	response to heat
NK6_RS19190	COG0318	PFAM AMP-dependent synthetase and ligase
NK6_RS19195	COG4221	oxidoreductase activity
NK6_RS19200	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
NK6_RS19205	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
NK6_RS19210	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NK6_RS19220	COG0473	3-isopropylmalate dehydrogenase activity
NK6_RS19235	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NK6_RS19240	COG0288	reversible hydration of carbon dioxide
NK6_RS19245	COG2301	Belongs to the HpcH HpaI aldolase family
NK6_RS19265	COG0066	3-isopropylmalate dehydratase activity
NK6_RS19315	COG0335	large ribosomal subunit rRNA binding
NK6_RS19320	COG0336	Belongs to the RNA methyltransferase TrmD family
NK6_RS19335	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NK6_RS19340	COG0228	four-way junction DNA binding
NK6_RS19345	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NK6_RS19370	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NK6_RS19375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NK6_RS19385	COG0564	pseudouridine synthase activity
NK6_RS19390	COG0552	protein localization to endoplasmic reticulum
NK6_RS19395	COG2917	probably involved in intracellular septation
NK6_RS19400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NK6_RS19410	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NK6_RS19415	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NK6_RS19420	COG4133	protoheme IX ABC transporter activity
NK6_RS19425	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NK6_RS19445	COG0670	Belongs to the BI1 family
NK6_RS19450	COG0577	efflux transmembrane transporter activity
NK6_RS19450	COG1136	(ABC) transporter
NK6_RS19455	COG4181	ATPase activity
NK6_RS19460	COG2755	lipolytic protein G-D-S-L family
NK6_RS19465	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NK6_RS19470	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NK6_RS19475	COG0039	L-malate dehydrogenase activity
NK6_RS19480	COG0045	succinate-CoA ligase (ADP-forming) activity
NK6_RS19490	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NK6_RS19500	COG0508	dehydrogenase complex catalyzes the overall conversion of
NK6_RS19505	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS19510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NK6_RS19525	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
NK6_RS19535	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NK6_RS19540	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NK6_RS19545	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NK6_RS19550	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NK6_RS19555	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NK6_RS19560	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NK6_RS19580	COG0494	nUDIX hydrolase
NK6_RS19585	COG1051	belongs to the nudix hydrolase family
NK6_RS19595	COG0793	Belongs to the peptidase S41A family
NK6_RS19605	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NK6_RS19615	COG0799	negative regulation of ribosome biogenesis
NK6_RS19620	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NK6_RS19625	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NK6_RS19630	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NK6_RS19645	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NK6_RS19665	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NK6_RS19670	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NK6_RS19690	COG4372	Transposase
NK6_RS19695	COG3344	reverse transcriptase
NK6_RS19700	COG4372	Transposase
NK6_RS19705	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS19775	COG1783	phage Terminase large subunit
NK6_RS19840	COG0473	3-isopropylmalate dehydrogenase activity
NK6_RS19855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NK6_RS19860	COG0583	DNA-binding transcription factor activity
NK6_RS19870	COG3181	Tripartite tricarboxylate transporter family receptor
NK6_RS19895	COG0697	spore germination
NK6_RS19900	COG0697	spore germination
NK6_RS19945	COG3437	response regulator, receiver
NK6_RS19955	COG0835	chemotaxis
NK6_RS19975	COG2201	protein-glutamate methylesterase activity
NK6_RS19985	COG4566	intracellular signal transduction
NK6_RS20030	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NK6_RS20040	COG1696	Membrane protein involved in D-alanine export
NK6_RS20080	COG2706	6-phosphogluconolactonase activity
NK6_RS20095	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NK6_RS20125	COG2171	N-acyltransferase activity
NK6_RS20140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NK6_RS20185	COG1846	Transcriptional regulator
NK6_RS20190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NK6_RS20205	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
NK6_RS20215	COG3813	Protein conserved in bacteria
NK6_RS20220	COG1522	sequence-specific DNA binding
NK6_RS20230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NK6_RS20275	COG2198	Histidine kinase
NK6_RS20275	COG0784	Response regulator, receiver
NK6_RS20275	COG5002	protein histidine kinase activity
NK6_RS20305	COG1877	trehalose-phosphatase activity
NK6_RS20310	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
NK6_RS20345	COG0210	DNA helicase
NK6_RS20350	COG4372	Transposase
NK6_RS20390	COG3052	prosthetic group binding
NK6_RS20410	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
NK6_RS20425	COG2169	Transcriptional regulator
NK6_RS20430	COG1566	PFAM secretion protein HlyD family protein
NK6_RS20450	COG4566	intracellular signal transduction
NK6_RS20455	COG4191	Histidine kinase
NK6_RS20475	COG3257	ureidoglycine aminohydrolase activity
NK6_RS20480	COG0583	DNA-binding transcription factor activity
NK6_RS20485	COG2814	Major facilitator Superfamily
NK6_RS20490	COG0667	Aldo Keto reductase
NK6_RS20510	COG2873	o-acetylhomoserine
NK6_RS20530	COG2515	1-aminocyclopropane-1-carboxylate deaminase
NK6_RS20535	COG1522	sequence-specific DNA binding
NK6_RS20545	COG2072	flavoprotein involved in K transport
NK6_RS20550	COG0583	DNA-binding transcription factor activity
NK6_RS20580	COG0657	acetylesterase activity
NK6_RS20595	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
NK6_RS20610	COG0697	spore germination
NK6_RS20620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NK6_RS20635	COG2890	protein-(glutamine-N5) methyltransferase activity
NK6_RS20640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NK6_RS20645	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
NK6_RS20650	COG0527	aspartate kinase activity
NK6_RS20660	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NK6_RS20675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NK6_RS20680	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NK6_RS20700	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NK6_RS20705	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NK6_RS20710	COG0653	protein targeting
NK6_RS20720	COG1846	Transcriptional regulator
NK6_RS20750	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NK6_RS20760	COG3034	peptidoglycan biosynthetic process
NK6_RS20765	COG0825	malonyl-CoA metabolic process
NK6_RS20770	COG4974	Belongs to the 'phage' integrase family
NK6_RS20780	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NK6_RS20785	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NK6_RS20790	COG4536	flavin adenine dinucleotide binding
NK6_RS20805	COG0372	Belongs to the citrate synthase family
NK6_RS20810	COG0372	Belongs to the citrate synthase family
NK6_RS20845	COG1902	pentaerythritol trinitrate reductase activity
NK6_RS20890	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NK6_RS20920	COG4372	Transposase
NK6_RS20930	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NK6_RS20945	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NK6_RS20950	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NK6_RS20960	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
NK6_RS20975	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NK6_RS20980	COG1845	cytochrome c oxidase, subunit III
NK6_RS20985	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NK6_RS20990	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NK6_RS20995	COG0477	Major facilitator Superfamily
NK6_RS21015	COG1024	Enoyl-CoA hydratase
NK6_RS21035	COG2801	Transposase and inactivated derivatives
NK6_RS21040	COG0582	viral genome integration into host DNA
NK6_RS21070	COG4386	tail sheath protein
NK6_RS21095	COG0740	serine-type endopeptidase activity
NK6_RS21165	COG1475	DNA binding
NK6_RS21170	COG4372	Transposase
NK6_RS21205	COG4584	PFAM Integrase catalytic
NK6_RS21335	COG1960	acyl-CoA dehydrogenase activity
NK6_RS21350	COG2261	transglycosylase associated protein
NK6_RS21360	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NK6_RS21385	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NK6_RS21510	COG2234	aminopeptidase activity
NK6_RS21550	COG3436	PFAM IS66 Orf2 family protein
NK6_RS21555	COG2433	Pfam Transposase IS66
NK6_RS21560	COG3318	Belongs to the UPF0149 family
NK6_RS21565	COG3547	Transposase (IS116 IS110 IS902 family)
NK6_RS21645	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS21730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NK6_RS21750	COG1960	acyl-CoA dehydrogenase activity
NK6_RS21765	COG1024	Enoyl-CoA hydratase
NK6_RS21775	COG0583	DNA-binding transcription factor activity
NK6_RS21780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NK6_RS21810	COG1846	Transcriptional regulator
NK6_RS21835	COG2130	NADP-dependent
NK6_RS21840	COG1301	dicarboxylic acid transport
NK6_RS21860	COG0069	glutamate synthase activity
NK6_RS21870	COG1253	flavin adenine dinucleotide binding
NK6_RS21880	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NK6_RS21905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NK6_RS21910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NK6_RS21925	COG4941	Belongs to the sigma-70 factor family
NK6_RS21950	COG0683	leucine binding
NK6_RS21965	COG2003	Belongs to the UPF0758 family
NK6_RS21980	COG0024	Methionine aminopeptidase
NK6_RS21985	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
NK6_RS21985	COG3264	Mechanosensitive ion channel
NK6_RS21990	COG3263	regulation of cellular component size
NK6_RS22000	COG0586	Pfam SNARE associated Golgi protein
NK6_RS22010	COG0438	transferase activity, transferring glycosyl groups
NK6_RS22015	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NK6_RS22020	COG4149	molybdate abc transporter
NK6_RS22025	COG0725	ABC transporter, periplasmic molybdate-binding protein
NK6_RS22035	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
NK6_RS22040	COG5001	Diguanylate cyclase
NK6_RS22045	COG1960	acyl-CoA dehydrogenase activity
NK6_RS22055	COG1794	racemase activity, acting on amino acids and derivatives
NK6_RS22075	COG0481	GTPase activity
NK6_RS22090	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
NK6_RS22090	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NK6_RS22100	COG2205	protein histidine kinase activity
NK6_RS22105	COG0745	RESPONSE REGULATOR receiver
NK6_RS22120	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NK6_RS22130	COG0058	SHG alpha-glucan phosphorylase activity
NK6_RS22155	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NK6_RS22160	COG0625	glutathione transferase activity
NK6_RS22165	COG1280	lysine exporter protein (LysE YggA)
NK6_RS22170	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NK6_RS22170	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NK6_RS22180	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NK6_RS22185	COG1643	Atp-dependent helicase
NK6_RS22195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NK6_RS22200	COG1522	sequence-specific DNA binding
NK6_RS22205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NK6_RS22235	COG0765	amino acid transport
NK6_RS22255	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NK6_RS22260	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NK6_RS22280	COG0242	peptide deformylase activity
NK6_RS22290	COG0101	tRNA pseudouridine synthase activity
NK6_RS22295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NK6_RS22300	COG3152	Membrane
NK6_RS22305	COG2171	N-acyltransferase activity
NK6_RS22320	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NK6_RS22330	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NK6_RS22345	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NK6_RS22465	COG5489	Protein of unknown function (DUF736)
NK6_RS22480	COG1250	3-hydroxyacyl-CoA dehydrogenase
NK6_RS22505	COG4178	(ABC) transporter
NK6_RS22510	COG3920	Histidine kinase
NK6_RS22530	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NK6_RS22540	COG3237	CsbD-like
NK6_RS22555	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NK6_RS22560	COG3237	CsbD-like
NK6_RS22575	COG0071	Belongs to the small heat shock protein (HSP20) family
NK6_RS22590	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NK6_RS22595	COG3038	cytochrome b561
NK6_RS22605	COG1408	metallophosphoesterase
NK6_RS22620	COG0662	Cupin 2, conserved barrel domain protein
NK6_RS22710	COG3550	peptidyl-serine autophosphorylation
NK6_RS22755	COG4584	PFAM Integrase catalytic
NK6_RS22790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NK6_RS22820	COG0789	Transcriptional regulator
NK6_RS22825	COG0583	DNA-binding transcription factor activity
NK6_RS22830	COG0583	DNA-binding transcription factor activity
NK6_RS22835	COG3153	acetyltransferase
NK6_RS22845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NK6_RS22850	COG2192	nodulation
NK6_RS22855	COG1131	(ABC) transporter
NK6_RS22860	COG0842	Transport permease protein
NK6_RS22865	COG2192	nodulation
NK6_RS22870	COG2192	nodulation
NK6_RS22885	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS22895	COG2086	electron transfer activity
NK6_RS22905	COG4372	Transposase
NK6_RS22910	COG3318	Belongs to the UPF0149 family
NK6_RS22915	COG2433	Pfam Transposase IS66
NK6_RS22920	COG3436	PFAM IS66 Orf2 family protein
NK6_RS22925	COG2963	transposase activity
NK6_RS22930	COG4974	Belongs to the 'phage' integrase family
NK6_RS22935	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS22965	COG1278	Cold shock
NK6_RS23020	COG0135	phosphoribosylanthranilate isomerase activity
NK6_RS23055	COG2205	protein histidine kinase activity
NK6_RS23055	COG0784	Response regulator, receiver
NK6_RS23055	COG2198	Histidine kinase
NK6_RS23075	COG2086	electron transfer activity
NK6_RS23085	COG1250	3-hydroxyacyl-CoA dehydrogenase
NK6_RS23095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NK6_RS23100	COG0165	Argininosuccinate lyase
NK6_RS23110	COG0019	diaminopimelate decarboxylase activity
NK6_RS23120	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NK6_RS23135	COG2204	response regulator
NK6_RS23150	COG2801	Transposase and inactivated derivatives
NK6_RS23155	COG2884	Cell division ATP-binding protein ftsE
NK6_RS23185	COG0287	Prephenate dehydrogenase
NK6_RS23200	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NK6_RS23205	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NK6_RS23205	COG2813	Specifically methylates the guanine in position
NK6_RS23225	COG0542	response to heat
NK6_RS23240	COG0739	heme binding
NK6_RS23290	COG4584	PFAM Integrase catalytic
NK6_RS23300	COG4372	Transposase
NK6_RS23320	COG0582	viral genome integration into host DNA
NK6_RS23330	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NK6_RS23375	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NK6_RS23375	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NK6_RS23390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NK6_RS23405	COG0601	transmembrane transport
NK6_RS23410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NK6_RS23420	COG4608	Belongs to the ABC transporter superfamily
NK6_RS23450	COG4251	negative regulation of phosphorylation
NK6_RS23450	COG3706	GGDEF domain
NK6_RS23450	COG2203	Gaf domain
NK6_RS23450	COG5001	Diguanylate cyclase
NK6_RS23455	COG3360	Dodecin
NK6_RS23460	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
NK6_RS23460	COG2273	Hydrolase Family 16
NK6_RS23465	COG2723	6-phospho-beta-galactosidase activity
NK6_RS23575	COG0025	NhaP-type Na H and K H
NK6_RS23590	COG0435	Glutathione S-transferase
NK6_RS23610	COG1335	isochorismatase
NK6_RS23680	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NK6_RS23700	COG2205	protein histidine kinase activity
NK6_RS23700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NK6_RS23710	COG0438	transferase activity, transferring glycosyl groups
NK6_RS23735	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NK6_RS23755	COG2801	Transposase and inactivated derivatives
NK6_RS23790	COG3547	Transposase (IS116 IS110 IS902 family)
NK6_RS23810	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NK6_RS23855	COG0824	Thioesterase
NK6_RS23860	COG0824	Thioesterase
NK6_RS23870	COG0519	Catalyzes the synthesis of GMP from XMP
NK6_RS23870	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NK6_RS23890	COG0765	amino acid transport
NK6_RS23900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NK6_RS23920	COG0402	S-adenosylhomocysteine deaminase activity
NK6_RS23935	COG3842	ATPase activity
NK6_RS23940	COG1176	ABC-type spermidine putrescine transport system, permease component I
NK6_RS23945	COG1177	transmembrane transport
NK6_RS23975	COG0488	(ABC) transporter
NK6_RS23980	COG1301	dicarboxylic acid transport
NK6_RS23985	COG2233	PERMEase
NK6_RS24040	COG0625	glutathione transferase activity
NK6_RS24055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NK6_RS24060	COG3795	YCII-related domain
NK6_RS24065	COG4941	Belongs to the sigma-70 factor family
NK6_RS24095	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS24135	COG1045	serine acetyltransferase
NK6_RS24165	COG0823	Involved in the tonB-independent uptake of proteins
NK6_RS24170	COG5001	Diguanylate cyclase
NK6_RS24180	COG2885	chlorophyll binding
NK6_RS24190	COG0037	tRNA processing
NK6_RS24195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NK6_RS24230	COG1309	transcriptional regulator
NK6_RS24240	COG0469	pyruvate kinase activity
NK6_RS24255	COG3750	Belongs to the UPF0335 family
NK6_RS24270	COG2989	Protein conserved in bacteria
NK6_RS24275	COG2204	response regulator
NK6_RS24320	COG0387	Pfam Sodium calcium exchanger
NK6_RS24340	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NK6_RS24345	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NK6_RS24350	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NK6_RS24355	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NK6_RS24360	COG5001	Diguanylate cyclase
NK6_RS24360	COG3447	MASE1 domain protein
NK6_RS24360	COG5002	protein histidine kinase activity
NK6_RS24415	COG3842	ATPase activity
NK6_RS24420	COG1176	ABC-type spermidine putrescine transport system, permease component I
NK6_RS24425	COG1177	transmembrane transport
NK6_RS24440	COG1175	transmembrane transport
NK6_RS24450	COG0583	DNA-binding transcription factor activity
NK6_RS24455	COG2828	Protein conserved in bacteria
NK6_RS24460	COG1301	dicarboxylic acid transport
NK6_RS24510	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NK6_RS24535	COG4566	intracellular signal transduction
NK6_RS24545	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
NK6_RS24550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NK6_RS24565	COG4771	TonB-dependent receptor
NK6_RS24585	COG0848	biopolymer transport protein
NK6_RS24610	COG0596	Alpha beta hydrolase
NK6_RS24615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NK6_RS24620	COG0395	ABC-type sugar transport system, permease component
NK6_RS24625	COG1175	transmembrane transport
NK6_RS24635	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NK6_RS24695	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NK6_RS24700	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NK6_RS24745	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NK6_RS24750	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NK6_RS24760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NK6_RS24765	COG3005	denitrification pathway
NK6_RS24770	COG3043	anaerobic respiration
NK6_RS24775	COG0243	molybdopterin cofactor binding
NK6_RS24800	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS24805	COG4689	acetoacetate decarboxylase
NK6_RS24850	COG1309	transcriptional regulator
NK6_RS24895	COG0784	Response regulator, receiver
NK6_RS24895	COG2205	protein histidine kinase activity
NK6_RS24935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NK6_RS24965	COG4372	Transposase
NK6_RS24970	COG4372	Transposase
NK6_RS25080	COG1335	isochorismatase
NK6_RS25100	COG4191	Histidine kinase
NK6_RS25240	COG2801	Transposase and inactivated derivatives
NK6_RS25245	COG2267	carboxylic ester hydrolase activity
NK6_RS25275	COG0604	alcohol dehydrogenase
NK6_RS25290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NK6_RS25325	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS25330	COG4372	Transposase
NK6_RS25365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NK6_RS25370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NK6_RS25380	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NK6_RS25420	COG5489	Protein of unknown function (DUF736)
NK6_RS25425	COG4974	Belongs to the 'phage' integrase family
NK6_RS25430	COG0582	viral genome integration into host DNA
NK6_RS25435	COG4974	Belongs to the 'phage' integrase family
NK6_RS25440	COG5489	Protein of unknown function (DUF736)
NK6_RS25480	COG2801	Transposase and inactivated derivatives
NK6_RS25500	COG1192	Involved in chromosome partitioning
NK6_RS25545	COG4962	Type ii secretion system protein e
NK6_RS25555	COG4584	PFAM Integrase catalytic
NK6_RS25560	COG0247	lactate metabolic process
NK6_RS25575	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NK6_RS25595	COG2801	Transposase and inactivated derivatives
NK6_RS25635	COG5489	Protein of unknown function (DUF736)
NK6_RS25640	COG4974	Belongs to the 'phage' integrase family
NK6_RS25645	COG0582	viral genome integration into host DNA
NK6_RS25650	COG4974	Belongs to the 'phage' integrase family
NK6_RS25655	COG5489	Protein of unknown function (DUF736)
NK6_RS25665	COG2801	Transposase and inactivated derivatives
NK6_RS25680	COG4372	Transposase
NK6_RS25685	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS25730	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NK6_RS25750	COG1278	Cold shock
NK6_RS25780	COG4584	PFAM Integrase catalytic
NK6_RS25790	COG2801	Transposase and inactivated derivatives
NK6_RS25830	COG1278	Cold shock
NK6_RS25840	COG3344	reverse transcriptase
NK6_RS25860	COG4372	Transposase
NK6_RS25870	COG2801	Transposase and inactivated derivatives
NK6_RS25875	COG3344	reverse transcriptase
NK6_RS25900	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NK6_RS25930	COG3474	cytochrome
NK6_RS25935	COG0277	FAD linked oxidase domain protein
NK6_RS25945	COG0277	FAD linked oxidase domain protein
NK6_RS25950	COG0247	lactate metabolic process
NK6_RS25965	COG4178	(ABC) transporter
NK6_RS25970	COG1620	l-lactate permease
NK6_RS25985	COG0459	protein refolding
NK6_RS25990	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NK6_RS26005	COG1376	ErfK ybiS ycfS ynhG family protein
NK6_RS26005	COG1388	LysM domain
NK6_RS26010	COG3416	Protein conserved in bacteria
NK6_RS26025	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NK6_RS26030	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
NK6_RS26055	COG0312	modulator of DNA gyrase
NK6_RS26075	COG1519	Transferase
NK6_RS26080	COG1663	tetraacyldisaccharide 4'-kinase activity
NK6_RS26120	COG1570	exodeoxyribonuclease VII activity
NK6_RS26140	COG0151	Belongs to the GarS family
NK6_RS26145	COG0596	Alpha beta hydrolase
NK6_RS26150	COG0590	tRNA wobble adenosine to inosine editing
NK6_RS26155	COG1187	pseudouridine synthase activity
NK6_RS26160	COG0742	ribosomal rna small subunit methyltransferase
NK6_RS26165	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NK6_RS26210	COG0612	Peptidase, M16
NK6_RS26215	COG0612	Peptidase, M16
NK6_RS26225	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NK6_RS26230	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NK6_RS26235	COG0196	riboflavin kinase activity
NK6_RS26240	COG0745	RESPONSE REGULATOR receiver
NK6_RS26250	COG2771	luxR family
NK6_RS26250	COG2200	EAL domain
NK6_RS26255	COG1295	ribonuclease BN
NK6_RS26265	COG2890	protein-(glutamine-N5) methyltransferase activity
NK6_RS26270	COG0314	molybdopterin synthase activity
NK6_RS26280	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NK6_RS26285	COG0322	excinuclease ABC activity
NK6_RS26290	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NK6_RS26295	COG1278	Cold shock
NK6_RS26300	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NK6_RS26330	COG0745	RESPONSE REGULATOR receiver
NK6_RS26335	COG1846	Transcriptional regulator
NK6_RS26350	COG0124	histidyl-tRNA synthetase
NK6_RS26355	COG1942	4-Oxalocrotonate Tautomerase
NK6_RS26365	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NK6_RS26375	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NK6_RS26380	COG1181	Belongs to the D-alanine--D-alanine ligase family
NK6_RS26390	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NK6_RS26410	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NK6_RS26425	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NK6_RS26430	COG0193	aminoacyl-tRNA hydrolase activity
NK6_RS26435	COG0012	GTP binding
NK6_RS26445	COG2030	dehydratase
NK6_RS26485	COG0556	nucleotide-excision repair
NK6_RS26500	COG0583	DNA-binding transcription factor activity
NK6_RS26535	COG0667	Aldo Keto reductase
NK6_RS26555	COG0625	glutathione transferase activity
NK6_RS26560	COG0436	Aminotransferase
NK6_RS26570	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NK6_RS26580	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NK6_RS26605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NK6_RS26790	COG1278	Cold shock
NK6_RS26835	COG2205	protein histidine kinase activity
NK6_RS26840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NK6_RS26855	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS26860	COG4372	Transposase
NK6_RS26870	COG0183	Belongs to the thiolase family
NK6_RS26875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NK6_RS26895	COG0625	glutathione transferase activity
NK6_RS26910	COG2223	nitrite transmembrane transporter activity
NK6_RS26950	COG5489	Protein of unknown function (DUF736)
NK6_RS26955	COG4974	Belongs to the 'phage' integrase family
NK6_RS26960	COG5489	Protein of unknown function (DUF736)
NK6_RS27000	COG1192	Involved in chromosome partitioning
NK6_RS27050	COG4962	Type ii secretion system protein e
NK6_RS27055	COG3838	Conjugal transfer protein Trbc
NK6_RS27065	COG3451	type IV secretory pathway VirB4
NK6_RS27085	COG3701	Conjugal transfer protein
NK6_RS27095	COG2948	multi-organism process
NK6_RS27115	COG1126	abc transporter atp-binding protein
NK6_RS27120	COG0765	amino acid transport
NK6_RS27130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NK6_RS27145	COG1012	belongs to the aldehyde dehydrogenase family
NK6_RS27175	COG0765	amino acid transport
NK6_RS27180	COG0765	amino acid transport
NK6_RS27185	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NK6_RS27210	COG1431	PFAM Stem cell self-renewal protein Piwi
NK6_RS27235	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS27240	COG4372	Transposase
NK6_RS27275	COG3409	Peptidoglycan-binding domain 1 protein
NK6_RS27290	COG2801	Transposase and inactivated derivatives
NK6_RS27305	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NK6_RS27335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NK6_RS27340	COG0583	DNA-binding transcription factor activity
NK6_RS27345	COG0492	ferredoxin-NADP+ reductase activity
NK6_RS27350	COG1522	sequence-specific DNA binding
NK6_RS27355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NK6_RS27360	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NK6_RS27395	COG0505	Belongs to the CarA family
NK6_RS27410	COG0596	Alpha beta hydrolase
NK6_RS27415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NK6_RS27460	COG0640	Transcriptional regulator
NK6_RS27480	COG1280	lysine exporter protein (LysE YggA)
NK6_RS27520	COG0358	DNA primase activity
NK6_RS27525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NK6_RS27565	COG1280	lysine exporter protein (LysE YggA)
NK6_RS27570	COG3706	GGDEF domain
NK6_RS27585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NK6_RS27590	COG0564	pseudouridine synthase activity
NK6_RS27610	COG1615	UPF0182 protein
NK6_RS27655	COG0628	permease
NK6_RS27685	COG0651	ATP synthesis coupled electron transport
NK6_RS27690	COG1006	Multisubunit Na H antiporter MnhC subunit
NK6_RS27705	COG1320	monovalent cation:proton antiporter activity
NK6_RS27730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NK6_RS27745	COG2235	arginine
NK6_RS27765	COG2197	response regulator
NK6_RS27775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NK6_RS27805	COG1309	transcriptional regulator
NK6_RS27830	COG0318	PFAM AMP-dependent synthetase and ligase
NK6_RS27840	COG3284	Transcriptional regulator
NK6_RS27845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NK6_RS27855	COG3734	2-keto-3-deoxy-galactonokinase
NK6_RS27860	COG0800	Aldolase
NK6_RS27910	COG2205	protein histidine kinase activity
NK6_RS27915	COG0402	S-adenosylhomocysteine deaminase activity
NK6_RS27925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NK6_RS27935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NK6_RS27955	COG1960	acyl-CoA dehydrogenase activity
NK6_RS27960	COG1960	acyl-CoA dehydrogenase activity
NK6_RS27965	COG1024	Enoyl-CoA hydratase
NK6_RS27970	COG1704	LemA family
NK6_RS27975	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
NK6_RS28000	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NK6_RS28000	COG0506	proline dehydrogenase activity
NK6_RS28000	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NK6_RS28010	COG1278	Cold shock
NK6_RS28035	COG3768	UPF0283 membrane protein
NK6_RS28040	COG3106	COG3106 Predicted ATPase
NK6_RS28045	COG1272	protein, Hemolysin III
NK6_RS28050	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS28060	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS28070	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
NK6_RS28080	COG1960	acyl-CoA dehydrogenase activity
NK6_RS28085	COG0583	DNA-binding transcription factor activity
NK6_RS28105	COG0501	Belongs to the peptidase M48B family
NK6_RS28110	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NK6_RS28125	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NK6_RS28135	COG2226	methyltransferase
NK6_RS28145	COG1376	ErfK ybiS ycfS ynhG family protein
NK6_RS28145	COG1388	LysM domain
NK6_RS28150	COG0028	Belongs to the TPP enzyme family
NK6_RS28160	COG1376	ErfK ybiS ycfS ynhG family protein
NK6_RS28195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NK6_RS28430	COG2198	Histidine kinase
NK6_RS28430	COG0643	Histidine kinase
NK6_RS28430	COG0784	Response regulator, receiver
NK6_RS28435	COG0835	chemotaxis
NK6_RS28440	COG0643	Histidine kinase
NK6_RS28440	COG2198	Histidine kinase
NK6_RS28440	COG0784	Response regulator, receiver
NK6_RS28460	COG0754	glutathionylspermidine amidase activity
NK6_RS28485	COG1595	DNA-templated transcription, initiation
NK6_RS28510	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NK6_RS28555	COG1309	transcriptional regulator
NK6_RS28560	COG2080	2 iron, 2 sulfur cluster binding
NK6_RS28565	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NK6_RS28575	COG3620	sequence-specific DNA binding
NK6_RS28580	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NK6_RS28585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NK6_RS28600	COG0765	amino acid transport
NK6_RS28605	COG1126	abc transporter atp-binding protein
NK6_RS28610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NK6_RS28620	COG0405	Gamma-glutamyltransferase
NK6_RS28625	COG1024	Enoyl-CoA hydratase
NK6_RS28650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NK6_RS28670	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NK6_RS28745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NK6_RS28770	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NK6_RS28855	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NK6_RS28925	COG0746	molybdenum cofactor guanylyltransferase activity
NK6_RS28935	COG1763	Mo-molybdopterin cofactor biosynthetic process
NK6_RS28950	COG2223	nitrite transmembrane transporter activity
NK6_RS28960	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NK6_RS28965	COG3383	formate dehydrogenase (NAD+) activity
NK6_RS28970	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NK6_RS28980	COG3976	FMN-binding domain protein
NK6_RS28980	COG0431	NADPH-dependent FMN reductase
NK6_RS28980	COG1053	succinate dehydrogenase
NK6_RS29020	COG5001	Diguanylate cyclase
NK6_RS29020	COG5002	protein histidine kinase activity
NK6_RS29020	COG3447	MASE1 domain protein
NK6_RS29025	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NK6_RS29040	COG0346	lactoylglutathione lyase activity
NK6_RS29050	COG0583	DNA-binding transcription factor activity
NK6_RS29060	COG3485	protocatechuate 3,4-dioxygenase
NK6_RS29100	COG0745	RESPONSE REGULATOR receiver
NK6_RS29105	COG2198	Histidine kinase
NK6_RS29105	COG0643	Histidine kinase
NK6_RS29110	COG0835	chemotaxis
NK6_RS29120	COG0835	chemotaxis
NK6_RS29125	COG0840	transmembrane signaling receptor activity
NK6_RS29135	COG2201	protein-glutamate methylesterase activity
NK6_RS29185	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NK6_RS29195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NK6_RS29215	COG0489	protein tyrosine kinase activity
NK6_RS29215	COG3206	protein involved in exopolysaccharide biosynthesis
NK6_RS29240	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NK6_RS29240	COG2755	lipolytic protein G-D-S-L family
NK6_RS29250	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NK6_RS29255	COG2244	polysaccharide biosynthetic process
NK6_RS29260	COG1045	serine acetyltransferase
NK6_RS29275	COG0438	transferase activity, transferring glycosyl groups
NK6_RS29320	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NK6_RS29345	COG3474	cytochrome
NK6_RS29365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NK6_RS29375	COG5001	Diguanylate cyclase
NK6_RS29375	COG3300	MHYT domain
NK6_RS29385	COG1309	transcriptional regulator
NK6_RS29395	COG0181	hydroxymethylbilane synthase activity
NK6_RS29400	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NK6_RS29410	COG5001	Diguanylate cyclase
NK6_RS29410	COG4251	negative regulation of phosphorylation
NK6_RS29410	COG3706	GGDEF domain
NK6_RS29410	COG2203	Gaf domain
NK6_RS29415	COG2900	Belongs to the SlyX family
NK6_RS29420	COG1054	Belongs to the UPF0176 family
NK6_RS29425	COG0405	Gamma-glutamyltransferase
NK6_RS29435	COG3237	CsbD-like
NK6_RS29470	COG0784	Response regulator, receiver
NK6_RS29470	COG4191	Histidine kinase
NK6_RS29485	COG2885	chlorophyll binding
NK6_RS29485	COG3047	cAMP biosynthetic process
NK6_RS29530	COG1309	transcriptional regulator
NK6_RS29550	COG1250	3-hydroxyacyl-CoA dehydrogenase
NK6_RS29550	COG1024	Enoyl-CoA hydratase
NK6_RS29560	COG1607	acyl-coa hydrolase
NK6_RS29580	COG1349	DNA-binding transcription factor activity
NK6_RS29600	COG3842	ATPase activity
NK6_RS29605	COG3842	ATPase activity
NK6_RS29615	COG0395	ABC-type sugar transport system, permease component
NK6_RS29635	COG2197	response regulator
NK6_RS29640	COG1902	pentaerythritol trinitrate reductase activity
NK6_RS29665	COG0501	Belongs to the peptidase M48B family
NK6_RS29715	COG0494	nUDIX hydrolase
NK6_RS29720	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NK6_RS29725	COG4771	TonB-dependent receptor
NK6_RS29750	COG0714	Associated with various cellular activities
NK6_RS29810	COG0408	coproporphyrinogen oxidase activity
NK6_RS29820	COG0602	queuosine metabolic process
NK6_RS29825	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NK6_RS29830	COG0723	plastoquinol--plastocyanin reductase activity
NK6_RS29835	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NK6_RS29835	COG2857	Cytochrome c1
NK6_RS29855	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NK6_RS29875	COG1704	LemA family
NK6_RS29885	COG1196	nuclear chromosome segregation
NK6_RS29890	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NK6_RS29890	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NK6_RS29920	COG0625	glutathione transferase activity
NK6_RS29950	COG0625	glutathione transferase activity
NK6_RS29960	COG2189	Belongs to the N(4) N(6)-methyltransferase family
NK6_RS29965	COG2321	neutral zinc metallopeptidase
NK6_RS29970	COG0521	Mo-molybdopterin cofactor biosynthetic process
NK6_RS29975	COG0456	acetyltransferase
NK6_RS29975	COG1846	Transcriptional regulator
NK6_RS29990	COG0574	Belongs to the PEP-utilizing enzyme family
NK6_RS29990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NK6_RS30005	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NK6_RS30010	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
NK6_RS30025	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NK6_RS30035	COG1573	uracil-dna glycosylase
NK6_RS30050	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NK6_RS30060	COG1280	lysine exporter protein (LysE YggA)
NK6_RS30065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NK6_RS30075	COG0142	geranyltranstransferase activity
NK6_RS30100	COG0752	glycyl-tRNA synthetase alpha subunit
NK6_RS30105	COG0751	glycine-tRNA ligase activity
NK6_RS30115	COG0574	Belongs to the PEP-utilizing enzyme family
NK6_RS30115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NK6_RS30130	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NK6_RS30135	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NK6_RS30150	COG0604	alcohol dehydrogenase
NK6_RS30195	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
NK6_RS30200	COG0519	Catalyzes the synthesis of GMP from XMP
NK6_RS30205	COG0354	folic acid binding
NK6_RS30210	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NK6_RS30215	COG2897	thiosulfate sulfurtransferase activity
NK6_RS30220	COG1595	DNA-templated transcription, initiation
NK6_RS30255	COG2135	peptidase activity
NK6_RS30270	COG0494	nUDIX hydrolase
NK6_RS30280	COG0277	FAD linked oxidase domain protein
NK6_RS30285	COG0009	L-threonylcarbamoyladenylate synthase
NK6_RS30330	COG4584	PFAM Integrase catalytic
NK6_RS30340	COG2801	Transposase and inactivated derivatives
NK6_RS30355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NK6_RS30410	COG1309	transcriptional regulator
NK6_RS30415	COG2814	Major facilitator Superfamily
NK6_RS30435	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
NK6_RS30455	COG1850	ribulose-bisphosphate carboxylase activity
NK6_RS30460	COG4451	ribulose bisphosphate carboxylase, small
NK6_RS30480	COG3300	MHYT domain
NK6_RS30480	COG5001	Diguanylate cyclase
NK6_RS30545	COG4999	Histidine kinase
NK6_RS30545	COG3437	response regulator, receiver
NK6_RS30545	COG2205	protein histidine kinase activity
NK6_RS30545	COG3850	Histidine kinase
NK6_RS30635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NK6_RS30645	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NK6_RS30645	COG0475	glutathione-regulated potassium exporter activity
NK6_RS30655	COG1960	acyl-CoA dehydrogenase activity
NK6_RS30670	COG0318	PFAM AMP-dependent synthetase and ligase
NK6_RS30690	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS30695	COG0259	pyridoxamine-phosphate oxidase activity
NK6_RS30720	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NK6_RS30735	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NK6_RS30745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NK6_RS30760	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NK6_RS30765	COG1993	acr, cog1993
NK6_RS30770	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NK6_RS30775	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NK6_RS30795	COG1024	Enoyl-CoA hydratase
NK6_RS30820	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NK6_RS30825	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
NK6_RS30835	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NK6_RS30840	COG1722	exodeoxyribonuclease VII activity
NK6_RS30845	COG0123	including yeast histone deacetylase and acetoin utilization protein
NK6_RS30850	COG1525	nuclease
NK6_RS30850	COG0737	Belongs to the 5'-nucleotidase family
NK6_RS30850	COG4085	toxin activity
NK6_RS30860	COG2223	nitrite transmembrane transporter activity
NK6_RS30865	COG1960	acyl-CoA dehydrogenase activity
NK6_RS30885	COG0556	nucleotide-excision repair
NK6_RS30915	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NK6_RS31090	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
NK6_RS31090	COG1672	PFAM Archaeal ATPase
NK6_RS31155	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS31160	COG4372	Transposase
NK6_RS31175	COG3119	arylsulfatase activity
NK6_RS31225	COG1879	ABC-type sugar transport system periplasmic component
NK6_RS31230	COG1172	Belongs to the binding-protein-dependent transport system permease family
NK6_RS31240	COG1129	ABC transporter
NK6_RS31255	COG0277	FAD linked oxidase domain protein
NK6_RS31260	COG3485	protocatechuate 3,4-dioxygenase
NK6_RS31270	COG0402	S-adenosylhomocysteine deaminase activity
NK6_RS31285	COG0583	DNA-binding transcription factor activity
NK6_RS31305	COG1012	belongs to the aldehyde dehydrogenase family
NK6_RS31340	COG1132	(ABC) transporter
NK6_RS31360	COG0741	lytic transglycosylase activity
NK6_RS31410	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NK6_RS31420	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NK6_RS31440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NK6_RS31445	COG1053	succinate dehydrogenase
NK6_RS31460	COG1335	isochorismatase
NK6_RS31480	COG3833	ABC-type maltose transport systems, permease component
NK6_RS31485	COG1175	transmembrane transport
NK6_RS31490	COG1653	transport
NK6_RS31495	COG3258	Cytochrome c
NK6_RS31515	COG0446	pyridine nucleotide-disulphide oxidoreductase
NK6_RS31520	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NK6_RS31520	COG2010	Cytochrome c
NK6_RS31545	COG1032	radical SAM domain protein
NK6_RS31550	COG2814	Major facilitator Superfamily
NK6_RS31555	COG0473	3-isopropylmalate dehydrogenase activity
NK6_RS31595	COG2264	protein methyltransferase activity
NK6_RS31605	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS31610	COG4106	trans-aconitate 2-methyltransferase activity
NK6_RS31625	COG2015	COG2015, Alkyl sulfatase and related hydrolases
NK6_RS31630	COG0438	transferase activity, transferring glycosyl groups
NK6_RS31635	COG1132	(ABC) transporter
NK6_RS31655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NK6_RS31660	COG0745	RESPONSE REGULATOR receiver
NK6_RS31665	COG4566	intracellular signal transduction
NK6_RS31670	COG4191	Histidine kinase
NK6_RS31680	COG0516	GMP reductase activity
NK6_RS31680	COG0517	IMP dehydrogenase activity
NK6_RS31685	COG3278	Belongs to the heme-copper respiratory oxidase family
NK6_RS31700	COG2010	Cytochrome c
NK6_RS31715	COG2217	Heavy metal translocating P-type atpase
NK6_RS31745	COG0583	DNA-binding transcription factor activity
NK6_RS31760	COG0297	glycogen (starch) synthase activity
NK6_RS31775	COG0473	3-isopropylmalate dehydrogenase activity
NK6_RS31785	COG1024	Enoyl-CoA hydratase
NK6_RS31790	COG2989	Protein conserved in bacteria
NK6_RS31810	COG1396	sequence-specific DNA binding
NK6_RS31825	COG0785	Cytochrome C biogenesis protein
NK6_RS31830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NK6_RS31835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NK6_RS31845	COG2207	Transcriptional regulator
NK6_RS31850	COG2202	Pas domain
NK6_RS31850	COG3920	Histidine kinase
NK6_RS31870	COG3485	protocatechuate 3,4-dioxygenase
NK6_RS31875	COG0515	serine threonine protein kinase
NK6_RS31885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NK6_RS31890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NK6_RS31895	COG1116	anion transmembrane transporter activity
NK6_RS31905	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NK6_RS31905	COG1017	nitric oxide dioxygenase activity
NK6_RS31910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NK6_RS31915	COG0243	molybdopterin cofactor binding
NK6_RS31920	COG0656	L-ascorbic acid biosynthetic process
NK6_RS31940	COG4372	Transposase
NK6_RS31950	COG1063	alcohol dehydrogenase
NK6_RS31960	COG1522	sequence-specific DNA binding
NK6_RS31965	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NK6_RS31980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NK6_RS32025	COG0129	dihydroxy-acid dehydratase activity
NK6_RS32055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NK6_RS32060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NK6_RS32070	COG1309	transcriptional regulator
NK6_RS32075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NK6_RS32095	COG0673	inositol 2-dehydrogenase activity
NK6_RS32135	COG0659	secondary active sulfate transmembrane transporter activity
NK6_RS32150	COG4372	Transposase
NK6_RS32155	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS32185	COG1980	fructose-bisphosphate aldolase activity
NK6_RS32200	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
NK6_RS32220	COG3119	arylsulfatase activity
NK6_RS32225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NK6_RS32230	COG2124	cytochrome p450
NK6_RS32240	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
NK6_RS32240	COG0028	Belongs to the TPP enzyme family
NK6_RS32245	COG1309	transcriptional regulator
NK6_RS32250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NK6_RS32255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NK6_RS32270	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
NK6_RS32290	COG0747	negative chemotaxis
NK6_RS32295	COG4608	Belongs to the ABC transporter superfamily
NK6_RS32300	COG0444	Belongs to the ABC transporter superfamily
NK6_RS32320	COG0444	Belongs to the ABC transporter superfamily
NK6_RS32325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NK6_RS32335	COG4166	transmembrane transport
NK6_RS32355	COG2267	carboxylic ester hydrolase activity
NK6_RS32400	COG2733	membrane
NK6_RS32405	COG0596	Alpha beta hydrolase
NK6_RS32410	COG3327	negative regulation of DNA-templated transcription, initiation
NK6_RS32415	COG3396	Phenylacetate-CoA oxygenase
NK6_RS32420	COG3460	Phenylacetate-CoA oxygenase
NK6_RS32425	COG3396	Phenylacetate-CoA oxygenase
NK6_RS32430	COG2151	metal-sulfur cluster biosynthetic enzyme
NK6_RS32435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NK6_RS32440	COG2050	protein possibly involved in aromatic compounds catabolism
NK6_RS32475	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NK6_RS32480	COG0477	Major facilitator Superfamily
NK6_RS32505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NK6_RS32510	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NK6_RS32520	COG4597	amino acid ABC transporter
NK6_RS32525	COG0765	amino acid transport
NK6_RS32535	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS32540	COG0473	3-isopropylmalate dehydrogenase activity
NK6_RS32545	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
NK6_RS32550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NK6_RS32560	COG0583	DNA-binding transcription factor activity
NK6_RS32565	COG4336	lyase activity
NK6_RS32595	COG0235	Class ii aldolase
NK6_RS32600	COG2084	Dehydrogenase
NK6_RS32605	COG3622	Belongs to the hyi family
NK6_RS32610	COG3395	kinase activity
NK6_RS32620	COG0840	transmembrane signaling receptor activity
NK6_RS32625	COG0840	transmembrane signaling receptor activity
NK6_RS32625	COG0840	transmembrane signaling receptor activity
NK6_RS32645	COG2070	2-Nitropropane dioxygenase
NK6_RS32650	COG2072	flavoprotein involved in K transport
NK6_RS32655	COG0625	glutathione transferase activity
NK6_RS32670	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS32675	COG1024	Enoyl-CoA hydratase
NK6_RS32690	COG1024	Enoyl-CoA hydratase
NK6_RS32695	COG1960	acyl-CoA dehydrogenase activity
NK6_RS32710	COG1024	Enoyl-CoA hydratase
NK6_RS32720	COG1024	Enoyl-CoA hydratase
NK6_RS32735	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NK6_RS32740	COG3386	PFAM SMP-30 Gluconolaconase
NK6_RS32745	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS32780	COG3145	DNA-N1-methyladenine dioxygenase activity
NK6_RS32790	COG0028	Belongs to the TPP enzyme family
NK6_RS32795	COG0179	Fumarylacetoacetate (FAA) hydrolase
NK6_RS32815	COG3971	2-oxopent-4-enoate hydratase activity
NK6_RS32820	COG1846	Transcriptional regulator
NK6_RS32835	COG2721	sulfolactate sulfo-lyase activity
NK6_RS32910	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NK6_RS32920	COG4303	Ethanolamine ammonia lyase large subunit
NK6_RS32930	COG4302	ethanolamine ammonia-lyase activity
NK6_RS32955	COG1562	ergosterol biosynthetic process
NK6_RS32960	COG1562	ergosterol biosynthetic process
NK6_RS32965	COG1233	COG1233 Phytoene dehydrogenase and related
NK6_RS32970	COG1657	PFAM Prenyltransferase squalene oxidase
NK6_RS32975	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NK6_RS32985	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NK6_RS33050	COG1473	amidohydrolase
NK6_RS33055	COG0306	phosphate transporter
NK6_RS33075	COG0587	DNA-directed DNA polymerase activity
NK6_RS33080	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS33090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NK6_RS33120	COG1024	Enoyl-CoA hydratase
NK6_RS33185	COG1703	isobutyryl-CoA mutase activity
NK6_RS33230	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NK6_RS33240	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NK6_RS33255	COG0433	COG0433 Predicted ATPase
NK6_RS33285	COG4957	zinc ion binding
NK6_RS33290	COG2166	iron-sulfur cluster assembly
NK6_RS33300	COG2205	protein histidine kinase activity
NK6_RS33335	COG0583	DNA-binding transcription factor activity
NK6_RS33425	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NK6_RS33435	COG0765	amino acid transport
NK6_RS33440	COG0765	amino acid transport
NK6_RS33445	COG1126	abc transporter atp-binding protein
NK6_RS33480	COG4372	Transposase
NK6_RS33490	COG1335	isochorismatase
NK6_RS33510	COG2983	Belongs to the UPF0260 family
NK6_RS33515	COG0477	Major facilitator Superfamily
NK6_RS33525	COG0784	Response regulator, receiver
NK6_RS33525	COG4191	Histidine kinase
NK6_RS33530	COG0028	Belongs to the TPP enzyme family
NK6_RS33555	COG0463	Glycosyl transferase, family 2
NK6_RS33570	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NK6_RS33575	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NK6_RS33580	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NK6_RS33600	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NK6_RS33625	COG4235	cytochrome complex assembly
NK6_RS33630	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
NK6_RS33635	COG1138	Cytochrome C-type biogenesis protein
NK6_RS33655	COG0745	RESPONSE REGULATOR receiver
NK6_RS33660	COG2205	protein histidine kinase activity
NK6_RS33665	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NK6_RS33675	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NK6_RS33680	COG3383	formate dehydrogenase (NAD+) activity
NK6_RS33695	COG0583	DNA-binding transcription factor activity
NK6_RS33700	COG2202	Pas domain
NK6_RS33700	COG2205	protein histidine kinase activity
NK6_RS33705	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NK6_RS33710	COG0604	alcohol dehydrogenase
NK6_RS33710	COG3321	synthase
NK6_RS33710	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS33735	COG0179	Fumarylacetoacetate (FAA) hydrolase
NK6_RS33740	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NK6_RS33760	COG0443	Heat shock 70 kDa protein
NK6_RS33775	COG1278	Cold shock
NK6_RS33795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NK6_RS33805	COG1802	Transcriptional regulator
NK6_RS33840	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NK6_RS33850	COG3622	Belongs to the hyi family
NK6_RS33855	COG2084	Dehydrogenase
NK6_RS33880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NK6_RS33900	COG1982	Orn Lys Arg decarboxylase major
NK6_RS33905	COG1522	sequence-specific DNA binding
NK6_RS33910	COG0686	Belongs to the AlaDH PNT family
NK6_RS33915	COG2072	flavoprotein involved in K transport
NK6_RS33920	COG1309	transcriptional regulator
NK6_RS33960	COG2855	membrane
NK6_RS33965	COG1116	anion transmembrane transporter activity
NK6_RS33970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NK6_RS33975	COG4521	taurine ABC transporter
NK6_RS33980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NK6_RS34000	COG1053	succinate dehydrogenase
NK6_RS34025	COG1129	ABC transporter
NK6_RS34030	COG1172	Belongs to the binding-protein-dependent transport system permease family
NK6_RS34035	COG1172	Belongs to the binding-protein-dependent transport system permease family
NK6_RS34055	COG3386	PFAM SMP-30 Gluconolaconase
NK6_RS34060	COG4213	ABC transporter substrate-binding protein
NK6_RS34065	COG1129	ABC transporter
NK6_RS34070	COG4214	carbohydrate transport
NK6_RS34075	COG1845	cytochrome c oxidase, subunit III
NK6_RS34090	COG3256	nitric oxide reductase
NK6_RS34095	COG0714	Associated with various cellular activities
NK6_RS34105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NK6_RS34130	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS34160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NK6_RS34170	COG4608	Belongs to the ABC transporter superfamily
NK6_RS34175	COG0747	negative chemotaxis
NK6_RS34205	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS34210	COG4372	Transposase
NK6_RS34230	COG3842	ATPase activity
NK6_RS34235	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NK6_RS34240	COG1177	transmembrane transport
NK6_RS34245	COG1176	ABC-type spermidine putrescine transport system, permease component I
NK6_RS34255	COG0400	carboxylic ester hydrolase activity
NK6_RS34260	COG0346	lactoylglutathione lyase activity
NK6_RS34265	COG0583	DNA-binding transcription factor activity
NK6_RS34295	COG0778	Nitroreductase
NK6_RS34300	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
NK6_RS34310	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
NK6_RS34320	COG1492	cobalamin metabolic process
NK6_RS34365	COG2099	Precorrin-6x reductase
NK6_RS34380	COG2875	Belongs to the precorrin methyltransferase family
NK6_RS34385	COG1797	cobyrinic acid a,c-diamide synthase activity
NK6_RS34390	COG1648	precorrin-2 dehydrogenase activity
NK6_RS34390	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NK6_RS34405	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NK6_RS34425	COG0154	amidase activity
NK6_RS34435	COG2351	hydroxyisourate hydrolase activity
NK6_RS34445	COG1176	ABC-type spermidine putrescine transport system, permease component I
NK6_RS34450	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NK6_RS34455	COG3842	ATPase activity
NK6_RS34460	COG0154	amidase activity
NK6_RS34470	COG1802	Transcriptional regulator
NK6_RS34480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NK6_RS34485	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
NK6_RS34500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NK6_RS34505	COG2030	dehydratase
NK6_RS34510	COG4670	ketone body catabolic process
NK6_RS34515	COG1960	acyl-CoA dehydrogenase activity
NK6_RS34525	COG1609	Transcriptional regulator
NK6_RS34530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NK6_RS34535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NK6_RS34555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NK6_RS34570	COG0765	amino acid transport
NK6_RS34575	COG1126	abc transporter atp-binding protein
NK6_RS34585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NK6_RS34590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NK6_RS34600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NK6_RS34605	COG0235	Class ii aldolase
NK6_RS34625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NK6_RS34660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NK6_RS34665	COG0318	PFAM AMP-dependent synthetase and ligase
NK6_RS34675	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NK6_RS34695	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS34700	COG2072	flavoprotein involved in K transport
NK6_RS34705	COG0747	negative chemotaxis
NK6_RS34710	COG0601	transmembrane transport
NK6_RS34715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NK6_RS34725	COG0747	negative chemotaxis
NK6_RS34730	COG0601	transmembrane transport
NK6_RS34735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NK6_RS34740	COG0444	Belongs to the ABC transporter superfamily
NK6_RS34745	COG4608	Belongs to the ABC transporter superfamily
NK6_RS34835	COG0445	tRNA wobble uridine modification
NK6_RS34850	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NK6_RS34855	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NK6_RS34860	COG3386	PFAM SMP-30 Gluconolaconase
NK6_RS34870	COG3618	amidohydrolase
NK6_RS34920	COG5564	TIM-barrel signal transduction protein
NK6_RS34965	COG1175	transmembrane transport
NK6_RS34970	COG0395	ABC-type sugar transport system, permease component
NK6_RS34975	COG0673	inositol 2-dehydrogenase activity
NK6_RS34985	COG1609	Transcriptional regulator
NK6_RS34995	COG0477	Major facilitator Superfamily
NK6_RS35025	COG0318	PFAM AMP-dependent synthetase and ligase
NK6_RS35030	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS35080	COG0179	Fumarylacetoacetate (FAA) hydrolase
NK6_RS35100	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NK6_RS35105	COG0596	Alpha beta hydrolase
NK6_RS35115	COG1846	Transcriptional regulator
NK6_RS35155	COG1764	response to oxidative stress
NK6_RS35195	COG0251	oxidation-reduction process
NK6_RS35210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NK6_RS35250	COG1960	acyl-CoA dehydrogenase activity
NK6_RS35255	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS35285	COG0628	permease
NK6_RS35300	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NK6_RS35305	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NK6_RS35315	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NK6_RS35320	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NK6_RS35335	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NK6_RS35360	COG4566	intracellular signal transduction
NK6_RS35380	COG2985	domain, Protein
NK6_RS35435	COG4191	Histidine kinase
NK6_RS35440	COG3064	Membrane
NK6_RS35470	COG0489	protein tyrosine kinase activity
NK6_RS35510	COG4964	Belongs to the GSP D family
NK6_RS35535	COG4584	PFAM Integrase catalytic
NK6_RS35545	COG0640	Transcriptional regulator
NK6_RS35555	COG0785	Cytochrome C biogenesis protein
NK6_RS35595	COG0737	Belongs to the 5'-nucleotidase family
NK6_RS35600	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NK6_RS35625	COG2391	methyltransferase activity
NK6_RS35630	COG2391	methyltransferase activity
NK6_RS35640	COG0640	Transcriptional regulator
NK6_RS35645	COG3181	Tripartite tricarboxylate transporter family receptor
NK6_RS35705	COG1024	Enoyl-CoA hydratase
NK6_RS35710	COG0477	Major facilitator Superfamily
NK6_RS35720	COG3395	kinase activity
NK6_RS35725	COG0235	Class ii aldolase
NK6_RS35730	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NK6_RS35735	COG3842	ATPase activity
NK6_RS35745	COG3833	ABC-type maltose transport systems, permease component
NK6_RS35800	COG3547	Transposase (IS116 IS110 IS902 family)
NK6_RS35805	COG2205	protein histidine kinase activity
NK6_RS35810	COG0745	RESPONSE REGULATOR receiver
NK6_RS35840	COG2188	Transcriptional regulator
NK6_RS35850	COG1175	transmembrane transport
NK6_RS35855	COG0395	ABC-type sugar transport system, permease component
NK6_RS35875	COG1461	Dihydroxyacetone kinase
NK6_RS35880	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
NK6_RS35900	COG2376	Dihydroxyacetone kinase
NK6_RS35935	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS35940	COG4372	Transposase
NK6_RS35955	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NK6_RS35955	COG4797	methyltransferase
NK6_RS36010	COG1716	ATPase activity
NK6_RS36020	COG2885	chlorophyll binding
NK6_RS36115	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NK6_RS36130	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NK6_RS36140	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS36155	COG1053	succinate dehydrogenase
NK6_RS36160	COG1053	succinate dehydrogenase
NK6_RS36165	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NK6_RS36175	COG0559	Belongs to the binding-protein-dependent transport system permease family
NK6_RS36210	COG1053	succinate dehydrogenase
NK6_RS36225	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS36255	COG1595	DNA-templated transcription, initiation
NK6_RS36260	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NK6_RS36290	COG1749	Flagellar hook protein flgE
NK6_RS36325	COG1136	(ABC) transporter
NK6_RS36325	COG0577	efflux transmembrane transporter activity
NK6_RS36350	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NK6_RS36355	COG2801	Transposase and inactivated derivatives
NK6_RS36375	COG4213	ABC transporter substrate-binding protein
NK6_RS36385	COG4214	carbohydrate transport
NK6_RS36405	COG1175	transmembrane transport
NK6_RS36415	COG0395	ABC-type sugar transport system, permease component
NK6_RS36425	COG3540	Alkaline phosphatase
NK6_RS36430	COG2390	Transcriptional regulator
NK6_RS36435	COG1063	alcohol dehydrogenase
NK6_RS36445	COG0483	inositol monophosphate 1-phosphatase activity
NK6_RS36450	COG1653	transport
NK6_RS36455	COG0395	ABC-type sugar transport system, permease component
NK6_RS36460	COG1175	transmembrane transport
NK6_RS36485	COG0508	dehydrogenase complex catalyzes the overall conversion of
NK6_RS36490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NK6_RS36495	COG1301	dicarboxylic acid transport
NK6_RS36510	COG0281	malic enzyme
NK6_RS36510	COG0280	phosphate acetyltransferase
NK6_RS36515	COG1252	NADH dehydrogenase
NK6_RS36520	COG1271	oxidase subunit
NK6_RS36530	COG2801	Transposase and inactivated derivatives
NK6_RS36535	COG1294	oxidase, subunit
NK6_RS36545	COG2204	response regulator
NK6_RS36550	COG3243	poly(R)-hydroxyalkanoic acid synthase
NK6_RS36560	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
NK6_RS36585	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
NK6_RS36590	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
NK6_RS36595	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
NK6_RS36600	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NK6_RS36620	COG2202	Pas domain
NK6_RS36620	COG2205	protein histidine kinase activity
NK6_RS36625	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NK6_RS36630	COG2084	Dehydrogenase
NK6_RS36645	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
NK6_RS36655	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
NK6_RS36665	COG0745	RESPONSE REGULATOR receiver
NK6_RS36670	COG5002	protein histidine kinase activity
NK6_RS36685	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
NK6_RS36690	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NK6_RS36700	COG0546	phosphoglycolate phosphatase activity
NK6_RS36705	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NK6_RS36740	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NK6_RS36745	COG0121	glutamine amidotransferase
NK6_RS36755	COG1017	nitric oxide dioxygenase activity
NK6_RS36755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NK6_RS36775	COG0861	Integral membrane protein TerC family
NK6_RS36790	COG0583	DNA-binding transcription factor activity
NK6_RS36805	COG1012	belongs to the aldehyde dehydrogenase family
NK6_RS36820	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
NK6_RS36825	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NK6_RS36850	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NK6_RS36855	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NK6_RS36875	COG0215	cysteine-tRNA ligase activity
NK6_RS36885	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NK6_RS36900	COG5265	(ABC) transporter
NK6_RS36905	COG0688	phosphatidylethanolamine metabolic process
NK6_RS36910	COG1183	phosphatidylcholine synthase activity
NK6_RS36925	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS36930	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NK6_RS36940	COG3158	transport of potassium into the cell
NK6_RS36945	COG3158	transport of potassium into the cell
NK6_RS36955	COG0436	Aminotransferase
NK6_RS36960	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NK6_RS36970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NK6_RS36980	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NK6_RS36985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NK6_RS37010	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NK6_RS37015	COG1285	pathogenesis
NK6_RS37035	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NK6_RS37035	COG2010	Cytochrome c
NK6_RS37040	COG2080	2 iron, 2 sulfur cluster binding
NK6_RS37080	COG1846	Transcriptional regulator
NK6_RS37135	COG3618	amidohydrolase
NK6_RS37145	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NK6_RS37200	COG1289	transmembrane transporter activity
NK6_RS37210	COG1566	PFAM secretion protein HlyD family protein
NK6_RS37220	COG0318	PFAM AMP-dependent synthetase and ligase
NK6_RS37230	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NK6_RS37310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NK6_RS37315	COG1309	transcriptional regulator
NK6_RS37325	COG2814	Major facilitator Superfamily
NK6_RS37330	COG1012	belongs to the aldehyde dehydrogenase family
NK6_RS37335	COG1802	Transcriptional regulator
NK6_RS37345	COG0477	Major facilitator Superfamily
NK6_RS37350	COG0402	S-adenosylhomocysteine deaminase activity
NK6_RS37360	COG1234	tRNA 3'-trailer cleavage
NK6_RS37380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NK6_RS37385	COG0277	FAD linked oxidase domain protein
NK6_RS37390	COG3395	kinase activity
NK6_RS37395	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NK6_RS37400	COG1454	alcohol dehydrogenase
NK6_RS37420	COG3547	Transposase (IS116 IS110 IS902 family)
NK6_RS37425	COG4584	PFAM Integrase catalytic
NK6_RS37460	COG2801	Transposase and inactivated derivatives
NK6_RS37475	COG5507	3-demethylubiquinone-9 3-methyltransferase
NK6_RS37495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NK6_RS37510	COG4774	siderophore transport
NK6_RS37515	COG3128	pkhd-type hydroxylase
NK6_RS37525	COG0848	biopolymer transport protein
NK6_RS37540	COG1994	Peptidase M50
NK6_RS37550	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NK6_RS37555	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS37560	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS37565	COG0129	dihydroxy-acid dehydratase activity
NK6_RS37570	COG1609	Transcriptional regulator
NK6_RS37575	COG3842	ATPase activity
NK6_RS37590	COG3833	ABC-type maltose transport systems, permease component
NK6_RS37595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NK6_RS37600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NK6_RS37605	COG0800	Aldolase
NK6_RS37610	COG0183	Belongs to the thiolase family
NK6_RS37620	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NK6_RS37625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NK6_RS37635	COG2186	Transcriptional regulator
NK6_RS37640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NK6_RS37665	COG2066	Belongs to the glutaminase family
NK6_RS37665	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
NK6_RS37680	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NK6_RS37690	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NK6_RS37710	COG0625	glutathione transferase activity
NK6_RS37745	COG2271	Major facilitator Superfamily
NK6_RS37750	COG0183	Belongs to the thiolase family
NK6_RS37755	COG1024	Enoyl-CoA hydratase
NK6_RS37780	COG1960	acyl-CoA dehydrogenase activity
NK6_RS37855	COG4584	PFAM Integrase catalytic
NK6_RS37995	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS38005	COG2814	Major facilitator Superfamily
NK6_RS38010	COG0583	DNA-binding transcription factor activity
NK6_RS38025	COG1671	Belongs to the UPF0178 family
NK6_RS38045	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
NK6_RS38060	COG2130	NADP-dependent
NK6_RS38070	COG1609	Transcriptional regulator
NK6_RS38080	COG0251	oxidation-reduction process
NK6_RS38095	COG0765	amino acid transport
NK6_RS38100	COG0765	amino acid transport
NK6_RS38130	COG1278	Cold shock
NK6_RS38145	COG0519	Catalyzes the synthesis of GMP from XMP
NK6_RS38145	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NK6_RS38155	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS38160	COG0583	DNA-binding transcription factor activity
NK6_RS38170	COG1510	regulation of RNA biosynthetic process
NK6_RS38195	COG1012	belongs to the aldehyde dehydrogenase family
NK6_RS38215	COG2207	Transcriptional regulator
NK6_RS38230	COG0242	peptide deformylase activity
NK6_RS38250	COG2814	Major facilitator Superfamily
NK6_RS38265	COG1764	response to oxidative stress
NK6_RS38270	COG1846	Transcriptional regulator
NK6_RS38285	COG1301	dicarboxylic acid transport
NK6_RS38290	COG1802	Transcriptional regulator
NK6_RS38350	COG0625	glutathione transferase activity
NK6_RS38360	COG0625	glutathione transferase activity
NK6_RS38370	COG1309	transcriptional regulator
NK6_RS38375	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NK6_RS38375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NK6_RS38380	COG1393	Belongs to the ArsC family
NK6_RS38415	COG1392	Phosphate transport regulator
NK6_RS38420	COG0306	phosphate transporter
NK6_RS38445	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NK6_RS38450	COG0318	PFAM AMP-dependent synthetase and ligase
NK6_RS38465	COG1160	GTP binding
NK6_RS38490	COG0300	oxidoreductase activity
NK6_RS38495	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NK6_RS38500	COG1286	toxin biosynthetic process
NK6_RS38550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NK6_RS38555	COG0305	Participates in initiation and elongation during chromosome replication
NK6_RS38560	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NK6_RS38580	COG0359	binds to the 23S rRNA
NK6_RS38590	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NK6_RS38595	COG0360	Binds together with S18 to 16S ribosomal RNA
NK6_RS38610	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NK6_RS38620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NK6_RS38625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NK6_RS38635	COG1561	YicC-like family, N-terminal region
NK6_RS38640	COG0194	GDP metabolic process
NK6_RS38680	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NK6_RS38685	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NK6_RS38705	COG0795	lipopolysaccharide-transporting ATPase activity
NK6_RS38710	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NK6_RS38740	COG3162	membrane
NK6_RS38745	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NK6_RS38755	COG2176	DNA-directed DNA polymerase activity
NK6_RS38760	COG0488	(ABC) transporter
NK6_RS38775	COG0105	UTP biosynthetic process
NK6_RS38780	COG0861	Integral membrane protein TerC family
NK6_RS38785	COG0248	Ppx GppA phosphatase
NK6_RS38790	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NK6_RS38800	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NK6_RS38805	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NK6_RS38810	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NK6_RS38815	COG1278	Cold shock
NK6_RS38845	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NK6_RS38850	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
NK6_RS38875	COG1175	transmembrane transport
NK6_RS38890	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NK6_RS38900	COG0281	malic enzyme
NK6_RS38900	COG0280	phosphate acetyltransferase
NK6_RS38920	COG0386	Belongs to the glutathione peroxidase family
NK6_RS38930	COG3045	CreA protein
NK6_RS38960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NK6_RS38975	COG3483	tryptophan 2,3-dioxygenase activity
NK6_RS39010	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS39015	COG2365	Tyrosine phosphatase family
NK6_RS39030	COG0174	glutamine synthetase
NK6_RS39080	COG2207	Transcriptional regulator
NK6_RS39105	COG0488	(ABC) transporter
NK6_RS39130	COG0657	acetylesterase activity
NK6_RS39140	COG0840	transmembrane signaling receptor activity
NK6_RS39160	COG2207	Transcriptional regulator
NK6_RS39210	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
NK6_RS39240	COG1309	transcriptional regulator
NK6_RS39250	COG0850	regulation of cytokinetic process
NK6_RS39255	COG2894	cell division
NK6_RS39260	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
NK6_RS39280	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS39295	COG1376	ErfK ybiS ycfS ynhG family protein
NK6_RS39330	COG1309	transcriptional regulator
NK6_RS39355	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
NK6_RS39405	COG2824	Alkylphosphonate utilization operon protein PhnA
NK6_RS39480	COG4372	Transposase
NK6_RS39485	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NK6_RS39490	COG0697	spore germination
NK6_RS39495	COG0784	Response regulator, receiver
NK6_RS39495	COG4191	Histidine kinase
NK6_RS39530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NK6_RS39540	COG0657	acetylesterase activity
NK6_RS39550	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NK6_RS39555	COG0745	RESPONSE REGULATOR receiver
NK6_RS39560	COG0784	Response regulator, receiver
NK6_RS39565	COG5002	protein histidine kinase activity
NK6_RS39570	COG0439	Biotin carboxylase
NK6_RS39575	COG0511	ligase activity, forming carbon-carbon bonds
NK6_RS39580	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NK6_RS39600	COG0436	Aminotransferase
NK6_RS39605	COG1268	BioY protein
NK6_RS39610	COG1301	dicarboxylic acid transport
NK6_RS39630	COG2271	Major facilitator Superfamily
NK6_RS39650	COG0860	N-Acetylmuramoyl-L-alanine amidase
NK6_RS39675	COG0697	spore germination
NK6_RS39700	COG0438	transferase activity, transferring glycosyl groups
NK6_RS39720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NK6_RS39735	COG0739	heme binding
NK6_RS39760	COG2259	Doxx family
NK6_RS39770	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NK6_RS39775	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NK6_RS39780	COG0625	glutathione transferase activity
NK6_RS39795	COG2945	thiolester hydrolase activity
NK6_RS39810	COG1104	cysteine desulfurase activity
NK6_RS39815	COG0719	Fe-S assembly protein
NK6_RS39820	COG0396	ATPase activity
NK6_RS39825	COG0719	Fe-S assembly protein
NK6_RS39830	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NK6_RS39835	COG2151	metal-sulfur cluster biosynthetic enzyme
NK6_RS39840	COG0316	Belongs to the HesB IscA family
NK6_RS39850	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NK6_RS39860	COG0513	Belongs to the DEAD box helicase family
NK6_RS39890	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS39905	COG0187	DNA topoisomerase II activity
NK6_RS39910	COG0586	Pfam SNARE associated Golgi protein
NK6_RS39935	COG3243	poly(R)-hydroxyalkanoic acid synthase
NK6_RS39945	COG0436	Aminotransferase
NK6_RS39955	COG1494	fructose-1,6-bisphosphatase
NK6_RS39975	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NK6_RS39985	COG1802	Transcriptional regulator
NK6_RS39995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NK6_RS40015	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NK6_RS40025	COG0840	transmembrane signaling receptor activity
NK6_RS40030	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NK6_RS40085	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NK6_RS40090	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
NK6_RS40105	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NK6_RS40200	COG3750	Belongs to the UPF0335 family
NK6_RS40280	COG0616	signal peptide processing
NK6_RS40450	COG0625	glutathione transferase activity
NK6_RS40465	COG4372	Transposase
NK6_RS40490	COG2801	Transposase and inactivated derivatives
NK6_RS40495	COG2267	carboxylic ester hydrolase activity
NK6_RS40515	COG0776	regulation of translation
NK6_RS40535	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NK6_RS40600	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NK6_RS40665	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NK6_RS40750	COG1074	ATP-dependent DNA helicase activity
NK6_RS40840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NK6_RS40985	COG1793	dna ligase
NK6_RS41090	COG3118	belongs to the thioredoxin family
NK6_RS41225	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NK6_RS41325	COG2189	Belongs to the N(4) N(6)-methyltransferase family
NK6_RS41335	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NK6_RS41430	COG0582	viral genome integration into host DNA
NK6_RS41450	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS41455	COG4372	Transposase
NK6_RS41460	COG2801	Transposase and inactivated derivatives
NK6_RS41470	COG4372	Transposase
NK6_RS41500	COG0546	phosphoglycolate phosphatase activity
NK6_RS41510	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NK6_RS41530	COG0629	single-stranded DNA binding
NK6_RS41540	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NK6_RS41545	COG3158	transport of potassium into the cell
NK6_RS41555	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NK6_RS41575	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NK6_RS41590	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NK6_RS41600	COG1309	transcriptional regulator
NK6_RS41635	COG0697	spore germination
NK6_RS41655	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NK6_RS41680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NK6_RS41705	COG0628	permease
NK6_RS41725	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NK6_RS41740	COG4584	PFAM Integrase catalytic
NK6_RS41765	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS41775	COG4372	Transposase
NK6_RS41790	COG4372	Transposase
NK6_RS41830	COG2723	6-phospho-beta-galactosidase activity
NK6_RS41850	COG0484	heat shock protein binding
NK6_RS41920	COG0516	GMP reductase activity
NK6_RS41920	COG0517	IMP dehydrogenase activity
NK6_RS41940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NK6_RS41950	COG0617	tRNA 3'-terminal CCA addition
NK6_RS41950	COG0517	IMP dehydrogenase activity
NK6_RS41950	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NK6_RS41955	COG0071	Belongs to the small heat shock protein (HSP20) family
NK6_RS41960	COG0459	protein refolding
NK6_RS41975	COG1136	(ABC) transporter
NK6_RS41980	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NK6_RS42050	COG1796	DNA polymerase
NK6_RS42050	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NK6_RS42055	COG0517	IMP dehydrogenase activity
NK6_RS42055	COG0617	tRNA 3'-terminal CCA addition
NK6_RS42055	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NK6_RS42060	COG0589	response to stress
NK6_RS42085	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NK6_RS42090	COG1278	Cold shock
NK6_RS42145	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NK6_RS42155	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NK6_RS42170	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NK6_RS42185	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NK6_RS42205	COG0667	Aldo Keto reductase
NK6_RS42215	COG1278	Cold shock
NK6_RS42265	COG0679	Auxin Efflux Carrier
NK6_RS42270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NK6_RS42275	COG1183	phosphatidylcholine synthase activity
NK6_RS42280	COG1253	flavin adenine dinucleotide binding
NK6_RS42290	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NK6_RS42310	COG0789	Transcriptional regulator
NK6_RS42315	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NK6_RS42325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NK6_RS42340	COG3707	response regulator
NK6_RS42345	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NK6_RS42350	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NK6_RS42355	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NK6_RS42360	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NK6_RS42375	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NK6_RS42375	COG0473	3-isopropylmalate dehydrogenase activity
NK6_RS42430	COG1175	transmembrane transport
NK6_RS42470	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NK6_RS42470	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NK6_RS42485	COG0444	Belongs to the ABC transporter superfamily
NK6_RS42495	COG0601	transmembrane transport
NK6_RS42500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NK6_RS42520	COG0129	dihydroxy-acid dehydratase activity
NK6_RS42580	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NK6_RS42590	COG1686	Belongs to the peptidase S11 family
NK6_RS42610	COG0084	hydrolase, TatD family'
NK6_RS42615	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NK6_RS42615	COG0321	lipoyl(octanoyl) transferase activity
NK6_RS42620	COG0318	PFAM AMP-dependent synthetase and ligase
NK6_RS42630	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NK6_RS42680	COG2011	ABC-type metal ion transport system permease component
NK6_RS42690	COG0471	metal ion transport
NK6_RS42715	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NK6_RS42720	COG3956	TIGRFAM MazG family protein
NK6_RS42725	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NK6_RS42730	COG1923	regulation of RNA biosynthetic process
NK6_RS42735	COG2204	response regulator
NK6_RS42740	COG5000	phosphorelay sensor kinase activity
NK6_RS42760	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NK6_RS42760	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NK6_RS42765	COG1546	Belongs to the CinA family
NK6_RS42765	COG1058	Belongs to the CinA family
NK6_RS42790	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NK6_RS42795	COG2863	cytochrome
NK6_RS42800	COG2867	negative regulation of translational initiation
NK6_RS42805	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NK6_RS42810	COG2094	Belongs to the DNA glycosylase MPG family
NK6_RS42815	COG0525	valine-tRNA ligase activity
NK6_RS42830	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NK6_RS42855	COG0251	oxidation-reduction process
NK6_RS42870	COG1126	abc transporter atp-binding protein
NK6_RS42905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NK6_RS42940	COG1126	abc transporter atp-binding protein
NK6_RS42945	COG0765	amino acid transport
NK6_RS42950	COG4597	amino acid ABC transporter
NK6_RS42955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NK6_RS42960	COG0626	cystathionine gamma-synthase activity
NK6_RS42965	COG1283	sodium-dependent phosphate transmembrane transporter activity
NK6_RS42980	COG0463	Glycosyl transferase, family 2
NK6_RS42985	COG0671	phosphoesterase, PA-phosphatase related
NK6_RS43000	COG2373	Large extracellular alpha-helical protein
NK6_RS43040	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NK6_RS43065	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
NK6_RS43065	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NK6_RS43070	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NK6_RS43075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NK6_RS43085	COG4770	biotin carboxylase activity
NK6_RS43090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NK6_RS43095	COG1960	acyl-CoA dehydrogenase activity
NK6_RS43115	COG1522	sequence-specific DNA binding
NK6_RS43140	COG4372	Transposase
NK6_RS43145	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS43265	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NK6_RS43315	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
NK6_RS43325	COG2340	Cysteine-rich secretory protein family
NK6_RS43340	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NK6_RS43360	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NK6_RS43365	COG1862	Preprotein translocase
NK6_RS43375	COG3119	arylsulfatase activity
NK6_RS43390	COG3119	arylsulfatase activity
NK6_RS43395	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NK6_RS43405	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NK6_RS43415	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NK6_RS43430	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NK6_RS43435	COG0805	protein transport
NK6_RS43440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NK6_RS43445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NK6_RS43450	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NK6_RS43455	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NK6_RS43460	COG1472	Belongs to the glycosyl hydrolase 3 family
NK6_RS43470	COG0018	arginyl-trna synthetase
NK6_RS43475	COG0232	Belongs to the dGTPase family. Type 2 subfamily
NK6_RS43485	COG2198	Histidine kinase
NK6_RS43485	COG5002	protein histidine kinase activity
NK6_RS43485	COG0784	Response regulator, receiver
NK6_RS43490	COG0708	Exodeoxyribonuclease III
NK6_RS43495	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
NK6_RS43500	COG0129	dihydroxy-acid dehydratase activity
NK6_RS43550	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS43555	COG4372	Transposase
NK6_RS43565	COG3344	reverse transcriptase
NK6_RS43570	COG4372	Transposase
NK6_RS43595	COG1793	dna ligase
NK6_RS43605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NK6_RS43650	COG2197	response regulator
NK6_RS43665	COG4297	protein containing double-stranded beta helix domain
NK6_RS43670	COG0671	phosphoesterase, PA-phosphatase related
NK6_RS43675	COG0723	plastoquinol--plastocyanin reductase activity
NK6_RS43690	COG2080	2 iron, 2 sulfur cluster binding
NK6_RS43695	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NK6_RS43700	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NK6_RS43730	COG0071	Belongs to the small heat shock protein (HSP20) family
NK6_RS43735	COG0071	Belongs to the small heat shock protein (HSP20) family
NK6_RS43750	COG0745	RESPONSE REGULATOR receiver
NK6_RS43780	COG0438	transferase activity, transferring glycosyl groups
NK6_RS43795	COG0071	Belongs to the small heat shock protein (HSP20) family
NK6_RS43800	COG0071	Belongs to the small heat shock protein (HSP20) family
NK6_RS43805	COG0071	Belongs to the small heat shock protein (HSP20) family
NK6_RS43825	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NK6_RS43840	COG0071	Belongs to the small heat shock protein (HSP20) family
NK6_RS43855	COG0071	Belongs to the small heat shock protein (HSP20) family
NK6_RS43860	COG0071	Belongs to the small heat shock protein (HSP20) family
NK6_RS43865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NK6_RS43905	COG4584	PFAM Integrase catalytic
NK6_RS43995	COG4191	Histidine kinase
NK6_RS44000	COG4566	intracellular signal transduction
NK6_RS44005	COG4566	intracellular signal transduction
NK6_RS44015	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NK6_RS44020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NK6_RS44030	COG0508	dehydrogenase complex catalyzes the overall conversion of
NK6_RS44050	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NK6_RS44055	COG1012	belongs to the aldehyde dehydrogenase family
NK6_RS44070	COG0431	NADPH-dependent FMN reductase
NK6_RS44080	COG1917	Cupin 2, conserved barrel domain protein
NK6_RS44080	COG4977	sequence-specific DNA binding
NK6_RS44085	COG4221	oxidoreductase activity
NK6_RS44105	COG0148	phosphopyruvate hydratase activity
NK6_RS44115	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NK6_RS44125	COG2066	Belongs to the glutaminase family
NK6_RS44125	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
NK6_RS44135	COG2877	3-deoxy-8-phosphooctulonate synthase activity
NK6_RS44145	COG0745	RESPONSE REGULATOR receiver
NK6_RS44155	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NK6_RS44160	COG0504	CTP synthase activity
NK6_RS44170	COG0149	triose-phosphate isomerase activity
NK6_RS44175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NK6_RS44180	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NK6_RS44185	COG0134	indole-3-glycerol-phosphate synthase activity
NK6_RS44190	COG0315	cyclic pyranopterin monophosphate synthase activity
NK6_RS44255	COG0793	Belongs to the peptidase S41A family
NK6_RS44260	COG1304	FMN binding
NK6_RS44265	COG1011	Hydrolase
NK6_RS44280	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NK6_RS44315	COG0477	Major facilitator Superfamily
NK6_RS44345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NK6_RS44350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NK6_RS44355	COG0372	Belongs to the citrate synthase family
NK6_RS44375	COG1175	transmembrane transport
NK6_RS44380	COG0395	ABC-type sugar transport system, permease component
NK6_RS44390	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS44395	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NK6_RS44405	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NK6_RS44415	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NK6_RS44420	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NK6_RS44425	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NK6_RS44430	COG0750	zinc metalloprotease
NK6_RS44435	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NK6_RS44445	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NK6_RS44450	COG0233	cytoplasmic translational termination
NK6_RS44455	COG0528	UMP kinase activity
NK6_RS44460	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NK6_RS44465	COG0052	Belongs to the universal ribosomal protein uS2 family
NK6_RS44485	COG0288	reversible hydration of carbon dioxide
NK6_RS44515	COG2814	Major facilitator Superfamily
NK6_RS44520	COG0024	Methionine aminopeptidase
NK6_RS44540	COG1136	(ABC) transporter
NK6_RS44550	COG0442	prolyl-tRNA aminoacylation
NK6_RS44590	COG1129	ABC transporter
NK6_RS44595	COG1172	Belongs to the binding-protein-dependent transport system permease family
NK6_RS44610	COG0583	DNA-binding transcription factor activity
NK6_RS44625	COG4608	Belongs to the ABC transporter superfamily
NK6_RS44630	COG0444	Belongs to the ABC transporter superfamily
NK6_RS44635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NK6_RS44650	COG4584	PFAM Integrase catalytic
NK6_RS44660	COG0747	negative chemotaxis
NK6_RS44680	COG0346	lactoylglutathione lyase activity
NK6_RS44695	COG1007	ATP synthesis coupled electron transport
NK6_RS44710	COG0713	ATP synthesis coupled electron transport
NK6_RS44720	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NK6_RS44725	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NK6_RS44735	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NK6_RS44745	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
NK6_RS44755	COG0649	NAD binding
NK6_RS44765	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NK6_RS44780	COG4774	siderophore transport
NK6_RS44810	COG2195	Cleaves the N-terminal amino acid of tripeptides
NK6_RS44820	COG1595	DNA-templated transcription, initiation
NK6_RS44845	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NK6_RS44880	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NK6_RS44880	COG2755	lipolytic protein G-D-S-L family
NK6_RS44895	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NK6_RS44900	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NK6_RS44910	COG0544	peptidyl-prolyl cis-trans isomerase activity
NK6_RS44925	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NK6_RS44925	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NK6_RS44930	COG0347	Belongs to the P(II) protein family
NK6_RS44935	COG0174	glutamine synthetase
NK6_RS44940	COG0252	asparaginase activity
NK6_RS44945	COG0330	HflC and HflK could
NK6_RS44965	COG3038	cytochrome b561
NK6_RS44975	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NK6_RS45000	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NK6_RS45005	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NK6_RS45015	COG1024	Enoyl-CoA hydratase
NK6_RS45035	COG1612	heme a metabolic process
NK6_RS45060	COG0438	transferase activity, transferring glycosyl groups
NK6_RS45075	COG1846	Transcriptional regulator
NK6_RS45080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NK6_RS45085	COG3268	Saccharopine dehydrogenase
NK6_RS45145	COG0657	acetylesterase activity
NK6_RS45155	COG0135	phosphoribosylanthranilate isomerase activity
NK6_RS45215	COG0776	regulation of translation
NK6_RS45220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NK6_RS45225	COG0416	fatty acid biosynthetic process
NK6_RS45250	COG2801	Transposase and inactivated derivatives
NK6_RS45260	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
NK6_RS45265	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NK6_RS45270	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NK6_RS45275	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NK6_RS45285	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NK6_RS45285	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NK6_RS45290	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NK6_RS45320	COG0113	porphobilinogen synthase activity
NK6_RS45330	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
NK6_RS45355	COG1914	H( )-stimulated, divalent metal cation uptake system
NK6_RS45365	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
NK6_RS45385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NK6_RS45425	COG0747	negative chemotaxis
NK6_RS45430	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NK6_RS45440	COG1381	Involved in DNA repair and RecF pathway recombination
NK6_RS45455	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NK6_RS45460	COG0571	ribonuclease III activity
NK6_RS45465	COG0681	Belongs to the peptidase S26 family
NK6_RS45470	COG0736	holo-[acyl-carrier-protein] synthase activity
NK6_RS45475	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NK6_RS45485	COG1758	RNA polymerase activity
NK6_RS45505	COG1970	mechanosensitive ion channel activity
NK6_RS45510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NK6_RS45515	COG0741	lytic transglycosylase activity
NK6_RS45525	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NK6_RS45555	COG4584	PFAM Integrase catalytic
NK6_RS45600	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NK6_RS45610	COG0154	amidase activity
NK6_RS45620	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NK6_RS45635	COG0583	DNA-binding transcription factor activity
NK6_RS45645	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NK6_RS45660	COG1960	acyl-CoA dehydrogenase activity
NK6_RS45670	COG0540	Belongs to the ATCase OTCase family
NK6_RS45680	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NK6_RS45695	COG0758	DNA mediated transformation
NK6_RS45700	COG1733	regulation of RNA biosynthetic process
NK6_RS45705	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NK6_RS45715	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS45745	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NK6_RS45750	COG0557	exoribonuclease II activity
NK6_RS45775	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NK6_RS45805	COG0784	Response regulator, receiver
NK6_RS45815	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NK6_RS45825	COG0494	nUDIX hydrolase
NK6_RS45855	COG0537	adenosine 5'-monophosphoramidase activity
NK6_RS45860	COG1720	tRNA m6t6A37 methyltransferase activity
NK6_RS45905	COG1482	cell wall glycoprotein biosynthetic process
NK6_RS45935	COG0667	Aldo Keto reductase
NK6_RS45945	COG2814	Major facilitator Superfamily
NK6_RS45960	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NK6_RS45985	COG1275	C4-dicarboxylate transporter malic acid transport protein
NK6_RS46000	COG1192	Involved in chromosome partitioning
NK6_RS46005	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NK6_RS46050	COG0656	L-ascorbic acid biosynthetic process
NK6_RS46060	COG2239	Acts as a magnesium transporter
NK6_RS46095	COG0321	lipoyl(octanoyl) transferase activity
NK6_RS46115	COG1090	epimerase
NK6_RS46135	COG1254	Belongs to the acylphosphatase family
NK6_RS46140	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NK6_RS46145	COG4770	biotin carboxylase activity
NK6_RS46155	COG5001	Diguanylate cyclase
NK6_RS46195	COG2271	Major facilitator Superfamily
NK6_RS46205	COG4948	Mandelate Racemase Muconate Lactonizing
NK6_RS46210	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS46215	COG1063	alcohol dehydrogenase
NK6_RS46230	COG2197	response regulator
NK6_RS46240	COG1414	Transcriptional regulator
NK6_RS46250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NK6_RS46255	COG0179	Fumarylacetoacetate (FAA) hydrolase
NK6_RS46300	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS46340	COG4566	intracellular signal transduction
NK6_RS46350	COG0577	efflux transmembrane transporter activity
NK6_RS46350	COG1136	(ABC) transporter
NK6_RS46355	COG1136	(ABC) transporter
NK6_RS46355	COG0577	efflux transmembrane transporter activity
NK6_RS46360	COG2197	response regulator
NK6_RS46380	COG0450	alkyl hydroperoxide reductase
NK6_RS46390	COG0415	Belongs to the DNA photolyase family
NK6_RS46495	COG1028	Short-chain dehydrogenase reductase Sdr
NK6_RS46500	COG2030	dehydratase
NK6_RS46530	COG2010	Cytochrome c
NK6_RS46530	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NK6_RS46535	COG2860	membrane
NK6_RS46590	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NK6_RS46615	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NK6_RS46675	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NK6_RS46720	COG3328	transposase activity
NK6_RS46735	COG4886	Leucine-rich repeat (LRR) protein
NK6_RS46745	COG3547	Transposase (IS116 IS110 IS902 family)
NK6_RS46760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NK6_RS46775	COG3505	Type IV secretory pathway VirD4
NK6_RS46785	COG3831	ATPase activity
NK6_RS46795	COG5489	Protein of unknown function (DUF736)
NK6_RS46815	COG2801	Transposase and inactivated derivatives
NK6_RS46845	COG0776	regulation of translation
NK6_RS46850	COG5489	Protein of unknown function (DUF736)
NK6_RS46865	COG1414	Transcriptional regulator
NK6_RS46870	COG1475	DNA binding
NK6_RS46875	COG1192	Involved in chromosome partitioning
NK6_RS46905	COG2801	Transposase and inactivated derivatives
NK6_RS46935	COG4584	PFAM Integrase catalytic
NK6_RS46950	COG2801	Transposase and inactivated derivatives
NK6_RS46965	COG3547	Transposase (IS116 IS110 IS902 family)
NK6_RS46970	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS47000	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS47020	COG2801	Transposase and inactivated derivatives
NK6_RS47025	COG1450	Type ii and iii secretion system protein
NK6_RS47055	COG3318	Belongs to the UPF0149 family
NK6_RS47070	COG2801	Transposase and inactivated derivatives
NK6_RS47075	COG3436	PFAM IS66 Orf2 family protein
NK6_RS47080	COG2963	transposase activity
NK6_RS47090	COG4669	(LipO)protein
NK6_RS47125	COG4584	PFAM Integrase catalytic
NK6_RS47130	COG1484	DNA-dependent DNA replication
NK6_RS47175	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NK6_RS47180	COG4790	Type iii secretion
NK6_RS47185	COG4794	Type iii secretion
NK6_RS47190	COG4791	protein targeting
NK6_RS47195	COG4792	protein secretion
NK6_RS47215	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS47220	COG4372	Transposase
NK6_RS47225	COG3344	reverse transcriptase
NK6_RS47230	COG3344	reverse transcriptase
NK6_RS47240	COG4372	Transposase
NK6_RS47255	COG4789	Type iii secretion
NK6_RS47290	COG0582	viral genome integration into host DNA
NK6_RS47295	COG4584	PFAM Integrase catalytic
NK6_RS47305	COG0582	viral genome integration into host DNA
NK6_RS47310	COG4974	Belongs to the 'phage' integrase family
NK6_RS47355	COG4584	PFAM Integrase catalytic
NK6_RS47360	COG4372	Transposase
NK6_RS47395	COG2801	Transposase and inactivated derivatives
NK6_RS47415	COG0326	Molecular chaperone. Has ATPase activity
NK6_RS47420	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NK6_RS47455	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NK6_RS47480	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NK6_RS47495	COG3335	DDE superfamily endonuclease
NK6_RS47515	COG1475	DNA binding
NK6_RS47520	COG1192	Involved in chromosome partitioning
NK6_RS47530	COG4962	Type ii secretion system protein e
NK6_RS47535	COG3838	Conjugal transfer protein Trbc
NK6_RS47545	COG3451	type IV secretory pathway VirB4
NK6_RS47550	COG5314	conjugation
NK6_RS47570	COG3701	Conjugal transfer protein
NK6_RS47610	COG4959	Type IV secretory pathway protease TraF
NK6_RS47770	COG1793	dna ligase
NK6_RS47825	COG4372	Transposase
NK6_RS47845	COG0071	Belongs to the small heat shock protein (HSP20) family
NK6_RS47865	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NK6_RS47870	COG4974	Belongs to the 'phage' integrase family
NK6_RS47875	COG0582	viral genome integration into host DNA
NK6_RS47880	COG4974	Belongs to the 'phage' integrase family
NK6_RS47915	COG1295	ribonuclease BN
NK6_RS47930	COG4297	protein containing double-stranded beta helix domain
NK6_RS47935	COG0671	phosphoesterase, PA-phosphatase related
NK6_RS47950	COG3685	Protein conserved in bacteria
NK6_RS47975	COG2433	Pfam Transposase IS66
NK6_RS47980	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS47990	COG2963	transposase activity
NK6_RS48010	COG0438	transferase activity, transferring glycosyl groups
NK6_RS48010	COG1216	Glycosyl transferase, family 2
NK6_RS48030	COG1088	dTDP-glucose 4,6-dehydratase activity
NK6_RS48070	COG2274	protein secretion by the type I secretion system
NK6_RS48095	COG3547	Transposase (IS116 IS110 IS902 family)
NK6_RS48125	COG4372	Transposase
NK6_RS48140	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NK6_RS48140	COG1328	CTP reductase activity
NK6_RS48160	COG2801	Transposase and inactivated derivatives
NK6_RS48180	COG3621	Patatin-like phospholipase
NK6_RS48225	COG5489	Protein of unknown function (DUF736)
NK6_RS48250	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
NK6_RS48260	COG1192	Involved in chromosome partitioning
NK6_RS48265	COG1475	DNA binding
NK6_RS48270	COG1414	Transcriptional regulator
NK6_RS48285	COG5489	Protein of unknown function (DUF736)
NK6_RS48290	COG5489	Protein of unknown function (DUF736)
NK6_RS48295	COG4974	Belongs to the 'phage' integrase family
NK6_RS48300	COG5489	Protein of unknown function (DUF736)
NK6_RS48400	COG4423	Transcription factor
NK6_RS48405	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
NK6_RS48420	COG1475	DNA binding
NK6_RS48435	COG4962	Type ii secretion system protein e
NK6_RS48450	COG3451	type IV secretory pathway VirB4
NK6_RS48455	COG5314	conjugation
NK6_RS48465	COG3846	protein secretion by the type IV secretion system
NK6_RS48470	COG2132	Multicopper oxidase
NK6_RS48520	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NK6_RS48560	COG3547	Transposase (IS116 IS110 IS902 family)
NK6_RS48570	COG1475	DNA binding
NK6_RS48630	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NK6_RS48645	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NK6_RS48675	COG2801	Transposase and inactivated derivatives
NK6_RS48725	COG3328	transposase activity
NK6_RS48740	COG4584	PFAM Integrase catalytic
NK6_RS48755	COG1475	DNA binding
NK6_RS48820	COG2963	transposase activity
NK6_RS48840	COG1484	DNA-dependent DNA replication
NK6_RS48845	COG2390	Transcriptional regulator
NK6_RS48845	COG4584	PFAM Integrase catalytic
NK6_RS48860	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NK6_RS48870	COG3328	transposase activity
NK6_RS48875	COG3328	transposase activity
NK6_RS48945	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
NK6_RS48975	COG5489	Protein of unknown function (DUF736)
NK6_RS48985	COG3831	ATPase activity
NK6_RS49015	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NK6_RS49020	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NK6_RS49025	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD