locus-tag	class	description
S58_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
S58_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
S58_RS00035	COG4691	Plasmid stability protein
S58_RS00045	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S58_RS00060	COG0534	Mate efflux family protein
S58_RS00085	COG1741	Belongs to the pirin family
S58_RS00090	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
S58_RS00105	COG0583	DNA-binding transcription factor activity
S58_RS00110	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS00130	COG0778	Nitroreductase
S58_RS00140	COG4948	Mandelate Racemase Muconate Lactonizing
S58_RS00185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S58_RS00190	COG0728	peptidoglycan biosynthetic process
S58_RS00195	COG0180	Tryptophanyl-tRNA synthetase
S58_RS00215	COG1214	PFAM Peptidase M22, glycoprotease
S58_RS00230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S58_RS00235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S58_RS00240	COG1702	phosphate starvation-inducible protein PhoH
S58_RS00245	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
S58_RS00250	COG1253	flavin adenine dinucleotide binding
S58_RS00255	COG0815	Transfers the fatty acyl group on membrane lipoproteins
S58_RS00260	COG1396	sequence-specific DNA binding
S58_RS00270	COG0220	tRNA (guanine-N7-)-methyltransferase activity
S58_RS00280	COG0779	Required for maturation of 30S ribosomal subunits
S58_RS00295	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
S58_RS00300	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
S58_RS00305	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
S58_RS00310	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
S58_RS00315	COG1185	polyribonucleotide nucleotidyltransferase activity
S58_RS00340	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
S58_RS00350	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S58_RS00380	COG0667	Aldo Keto reductase
S58_RS00385	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S58_RS00405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S58_RS00410	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
S58_RS00415	COG2226	methyltransferase
S58_RS00420	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
S58_RS00425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
S58_RS00430	COG0756	dUTP diphosphatase activity
S58_RS00435	COG2205	protein histidine kinase activity
S58_RS00440	COG3178	'Phosphotransferase
S58_RS00450	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
S58_RS00460	COG1074	ATP-dependent DNA helicase activity
S58_RS00470	COG1793	dna ligase
S58_RS00480	COG0285	dihydrofolate synthase activity
S58_RS00485	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
S58_RS00490	COG0159	tryptophan synthase activity
S58_RS00495	COG0133	tryptophan synthase activity
S58_RS00500	COG0135	phosphoribosylanthranilate isomerase activity
S58_RS00510	COG0776	regulation of translation
S58_RS00515	COG0616	signal peptide processing
S58_RS00520	COG0539	negative regulation of cytoplasmic translation
S58_RS00525	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
S58_RS00530	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
S58_RS00550	COG1846	Transcriptional regulator
S58_RS00555	COG1764	response to oxidative stress
S58_RS00570	COG1175	transmembrane transport
S58_RS00575	COG0395	ABC-type sugar transport system, permease component
S58_RS00580	COG3842	ATPase activity
S58_RS00585	COG0071	Belongs to the small heat shock protein (HSP20) family
S58_RS00600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S58_RS00605	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
S58_RS00610	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
S58_RS00615	COG1137	ATPase activity
S58_RS00620	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
S58_RS00650	COG2010	Cytochrome c
S58_RS00665	COG3278	Belongs to the heme-copper respiratory oxidase family
S58_RS00675	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
S58_RS00725	COG1091	dTDP-4-dehydrorhamnose reductase activity
S58_RS00730	COG1968	undecaprenyl-diphosphatase activity
S58_RS00740	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
S58_RS00750	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
S58_RS00760	COG0291	Belongs to the bacterial ribosomal protein bL35 family
S58_RS00765	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
S58_RS00770	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
S58_RS00775	COG2852	Protein conserved in bacteria
S58_RS00780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S58_RS00780	COG0072	phenylalanine-tRNA ligase activity
S58_RS00805	COG1937	Protein conserved in bacteria
S58_RS00835	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
S58_RS00845	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S58_RS00850	COG1404	Belongs to the peptidase S8 family
S58_RS00855	COG0464	growth
S58_RS00860	COG0588	phosphoglycerate mutase activity
S58_RS00865	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
S58_RS00875	COG0284	orotidine-5'-phosphate decarboxylase activity
S58_RS00880	COG0431	NADPH-dependent FMN reductase
S58_RS00885	COG3963	phosphatidate phosphatase activity
S58_RS00890	COG0484	heat shock protein binding
S58_RS00895	COG0443	Heat shock 70 kDa protein
S58_RS00915	COG1335	isochorismatase
S58_RS00920	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
S58_RS00925	COG1420	regulation of RNA biosynthetic process
S58_RS00930	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
S58_RS00935	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
S58_RS00940	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S58_RS00950	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
S58_RS00955	COG0792	nuclease activity
S58_RS00960	COG0189	ligase activity
S58_RS00975	COG0745	RESPONSE REGULATOR receiver
S58_RS00990	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
S58_RS00995	COG3706	GGDEF domain
S58_RS01000	COG3706	GGDEF domain
S58_RS01005	COG0495	leucyl-tRNA aminoacylation
S58_RS01030	COG0357	Ribosomal RNA small subunit methyltransferase G
S58_RS01035	COG0445	tRNA wobble uridine modification
S58_RS01040	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
S58_RS01045	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
S58_RS01050	COG1981	membrane
S58_RS01060	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
S58_RS01065	COG0424	maF-like protein
S58_RS01070	COG0237	dephospho-CoA kinase activity
S58_RS01075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
S58_RS01080	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
S58_RS01090	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
S58_RS01105	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
S58_RS01115	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
S58_RS01120	COG0131	Imidazoleglycerol-phosphate dehydratase
S58_RS01130	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
S58_RS01135	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
S58_RS01140	COG0107	imidazoleglycerol-phosphate synthase activity
S58_RS01145	COG0140	phosphoribosyl-ATP diphosphatase activity
S58_RS01150	COG1072	(Pantothenic acid kinase))
S58_RS01175	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
S58_RS01180	COG1674	ftsk spoiiie
S58_RS01185	COG0436	Aminotransferase
S58_RS01190	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
S58_RS01205	COG4221	oxidoreductase activity
S58_RS01210	COG0318	PFAM AMP-dependent synthetase and ligase
S58_RS01220	COG2009	succinate dehydrogenase
S58_RS01245	COG4178	(ABC) transporter
S58_RS01275	COG0137	argininosuccinate synthase activity
S58_RS01280	COG0671	phosphoesterase, PA-phosphatase related
S58_RS01290	COG0820	rRNA (adenine-C2-)-methyltransferase activity
S58_RS01320	COG2154	pterin-4-alpha-carbinolamine dehydratase
S58_RS01335	COG0784	Response regulator, receiver
S58_RS01345	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
S58_RS01360	COG1217	gtp-binding protein TYPA
S58_RS01375	COG2855	membrane
S58_RS01400	COG1247	-acetyltransferase
S58_RS01405	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
S58_RS01410	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
S58_RS01415	COG1872	DUF167
S58_RS01430	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
S58_RS01435	COG4221	oxidoreductase activity
S58_RS01460	COG2814	Major facilitator Superfamily
S58_RS01475	COG0300	oxidoreductase activity
S58_RS01530	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
S58_RS01535	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
S58_RS01550	COG3360	Dodecin
S58_RS01560	COG0004	ammonium transporteR
S58_RS01565	COG0347	Belongs to the P(II) protein family
S58_RS01570	COG0004	ammonium transporteR
S58_RS01575	COG0347	Belongs to the P(II) protein family
S58_RS01585	COG1946	Acyl-CoA thioesterase
S58_RS01590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S58_RS01600	COG2835	tetraacyldisaccharide 4'-kinase activity
S58_RS01630	COG3118	belongs to the thioredoxin family
S58_RS01650	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
S58_RS01655	COG0154	amidase activity
S58_RS01670	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S58_RS01685	COG0534	Mate efflux family protein
S58_RS01705	COG0405	Gamma-glutamyltransferase
S58_RS01725	COG0138	bifunctional purine biosynthesis protein purh
S58_RS01740	COG5508	conserved small protein
S58_RS01745	COG2895	sulfate adenylyltransferase (ATP) activity
S58_RS01745	COG0529	Catalyzes the synthesis of activated sulfate
S58_RS01750	COG0175	sulfate reduction
S58_RS01765	COG1376	ErfK ybiS ycfS ynhG family protein
S58_RS01770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S58_RS01785	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
S58_RS01790	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
S58_RS01795	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
S58_RS01805	COG0473	3-isopropylmalate dehydrogenase activity
S58_RS01810	COG1129	ABC transporter
S58_RS01815	COG1172	Belongs to the binding-protein-dependent transport system permease family
S58_RS01820	COG1879	ABC-type sugar transport system periplasmic component
S58_RS01835	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
S58_RS01840	COG0288	reversible hydration of carbon dioxide
S58_RS01845	COG2301	Belongs to the HpcH HpaI aldolase family
S58_RS01865	COG0066	3-isopropylmalate dehydratase activity
S58_RS01900	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
S58_RS01905	COG0335	large ribosomal subunit rRNA binding
S58_RS01910	COG0336	Belongs to the RNA methyltransferase TrmD family
S58_RS01920	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
S58_RS01925	COG0228	four-way junction DNA binding
S58_RS01930	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
S58_RS01950	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
S58_RS01955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S58_RS01960	COG0564	pseudouridine synthase activity
S58_RS01965	COG0552	protein localization to endoplasmic reticulum
S58_RS01970	COG2917	probably involved in intracellular septation
S58_RS01975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S58_RS01985	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
S58_RS01990	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
S58_RS01995	COG4133	protoheme IX ABC transporter activity
S58_RS02000	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
S58_RS02020	COG0670	Belongs to the BI1 family
S58_RS02025	COG0577	efflux transmembrane transporter activity
S58_RS02025	COG1136	(ABC) transporter
S58_RS02030	COG1136	(ABC) transporter
S58_RS02040	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
S58_RS02045	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
S58_RS02050	COG0039	L-malate dehydrogenase activity
S58_RS02055	COG0045	succinate-CoA ligase (ADP-forming) activity
S58_RS02060	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
S58_RS02070	COG0508	dehydrogenase complex catalyzes the overall conversion of
S58_RS02075	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS02080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S58_RS02095	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
S58_RS02105	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
S58_RS02110	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S58_RS02115	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
S58_RS02120	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
S58_RS02125	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
S58_RS02130	COG0355	proton-transporting ATP synthase activity, rotational mechanism
S58_RS02140	COG1051	belongs to the nudix hydrolase family
S58_RS02145	COG0494	nUDIX hydrolase
S58_RS02155	COG0793	Belongs to the peptidase S41A family
S58_RS02165	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
S58_RS02170	COG0799	negative regulation of ribosome biogenesis
S58_RS02175	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
S58_RS02180	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
S58_RS02185	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
S58_RS02190	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
S58_RS02205	COG0211	Belongs to the bacterial ribosomal protein bL27 family
S58_RS02210	COG0261	This protein binds to 23S rRNA in the presence of protein L20
S58_RS02250	COG3012	SEC-C Motif Domain Protein
S58_RS02255	COG2226	methyltransferase
S58_RS02275	COG3842	ATPase activity
S58_RS02280	COG1176	ABC-type spermidine putrescine transport system, permease component I
S58_RS02295	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
S58_RS02325	COG0438	transferase activity, transferring glycosyl groups
S58_RS02345	COG0438	transferase activity, transferring glycosyl groups
S58_RS02365	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
S58_RS02410	COG0745	RESPONSE REGULATOR receiver
S58_RS02415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S58_RS02425	COG4191	Histidine kinase
S58_RS02425	COG0784	Response regulator, receiver
S58_RS02440	COG0784	Response regulator, receiver
S58_RS02440	COG2198	Histidine kinase
S58_RS02440	COG0643	Histidine kinase
S58_RS02445	COG0835	chemotaxis
S58_RS02450	COG0784	Response regulator, receiver
S58_RS02450	COG0643	Histidine kinase
S58_RS02450	COG2198	Histidine kinase
S58_RS02470	COG4566	intracellular signal transduction
S58_RS02475	COG4191	Histidine kinase
S58_RS02475	COG0784	Response regulator, receiver
S58_RS02480	COG0784	Response regulator, receiver
S58_RS02480	COG2198	Histidine kinase
S58_RS02480	COG2205	protein histidine kinase activity
S58_RS02515	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
S58_RS02525	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
S58_RS02550	COG1376	ErfK ybiS ycfS ynhG family protein
S58_RS02585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S58_RS02605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S58_RS02620	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
S58_RS02630	COG3813	Protein conserved in bacteria
S58_RS02635	COG1522	sequence-specific DNA binding
S58_RS02645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
S58_RS02670	COG2271	Major facilitator Superfamily
S58_RS02680	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
S58_RS02695	COG0582	viral genome integration into host DNA
S58_RS02715	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
S58_RS02735	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
S58_RS02800	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
S58_RS02810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S58_RS02815	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
S58_RS02820	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
S58_RS02840	COG0745	RESPONSE REGULATOR receiver
S58_RS02845	COG5002	protein histidine kinase activity
S58_RS02845	COG2198	Histidine kinase
S58_RS02845	COG0784	Response regulator, receiver
S58_RS02850	COG0683	leucine binding
S58_RS02865	COG1131	(ABC) transporter
S58_RS02915	COG1960	acyl-CoA dehydrogenase activity
S58_RS02920	COG1960	acyl-CoA dehydrogenase activity
S58_RS02940	COG3246	L-lysine catabolic process to acetate
S58_RS02945	COG0318	PFAM AMP-dependent synthetase and ligase
S58_RS02965	COG3920	Histidine kinase
S58_RS02965	COG2202	Pas domain
S58_RS02975	COG0517	IMP dehydrogenase activity
S58_RS02975	COG0516	GMP reductase activity
S58_RS02980	COG0318	PFAM AMP-dependent synthetase and ligase
S58_RS02985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S58_RS03000	COG3788	relative of glutathione S-transferase, MAPEG superfamily
S58_RS03015	COG1136	(ABC) transporter
S58_RS03030	COG2271	Major facilitator Superfamily
S58_RS03035	COG3453	Protein conserved in bacteria
S58_RS03035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S58_RS03040	COG0737	Belongs to the 5'-nucleotidase family
S58_RS03050	COG3258	Cytochrome c
S58_RS03075	COG1505	serine-type exopeptidase activity
S58_RS03080	COG2814	Major facilitator Superfamily
S58_RS03090	COG1960	acyl-CoA dehydrogenase activity
S58_RS03095	COG1960	acyl-CoA dehydrogenase activity
S58_RS03100	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
S58_RS03105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S58_RS03115	COG1294	oxidase, subunit
S58_RS03120	COG1271	oxidase subunit
S58_RS03125	COG1595	DNA-templated transcription, initiation
S58_RS03135	COG0784	Response regulator, receiver
S58_RS03135	COG3437	response regulator, receiver
S58_RS03140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S58_RS03140	COG4191	Histidine kinase
S58_RS03160	COG0601	transmembrane transport
S58_RS03165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S58_RS03170	COG4172	Belongs to the ABC transporter superfamily
S58_RS03190	COG1802	Transcriptional regulator
S58_RS03210	COG2124	cytochrome p450
S58_RS03275	COG0010	Belongs to the arginase family
S58_RS03300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S58_RS03330	COG2885	chlorophyll binding
S58_RS03345	COG5002	protein histidine kinase activity
S58_RS03355	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S58_RS03360	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
S58_RS03380	COG2967	ApaG domain
S58_RS03405	COG0717	Belongs to the dCTP deaminase family
S58_RS03450	COG1022	Amp-dependent synthetase and ligase
S58_RS03475	COG1999	signal sequence binding
S58_RS03485	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
S58_RS03505	COG0167	dihydroorotate dehydrogenase activity
S58_RS03510	COG0534	Mate efflux family protein
S58_RS03515	COG1234	tRNA 3'-trailer cleavage
S58_RS03525	COG1793	dna ligase
S58_RS03530	COG1793	dna ligase
S58_RS03530	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
S58_RS03545	COG1201	RNA secondary structure unwinding
S58_RS03555	COG0583	DNA-binding transcription factor activity
S58_RS03575	COG0730	response to heat
S58_RS03590	COG1695	Transcriptional regulator
S58_RS03600	COG1960	acyl-CoA dehydrogenase activity
S58_RS03605	COG0183	Belongs to the thiolase family
S58_RS03610	COG1024	Enoyl-CoA hydratase
S58_RS03610	COG1250	3-hydroxyacyl-CoA dehydrogenase
S58_RS03620	COG0625	glutathione transferase activity
S58_RS03640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S58_RS03665	COG0312	modulator of DNA gyrase
S58_RS03680	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
S58_RS03685	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S58_RS03690	COG0109	protoheme IX farnesyltransferase activity
S58_RS03700	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
S58_RS03715	COG3346	SURF1 family
S58_RS03720	COG0789	Transcriptional regulator
S58_RS03725	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S58_RS03730	COG0384	phenazine biosynthesis protein PhzF
S58_RS03740	COG0393	Putative heavy-metal-binding
S58_RS03755	COG0612	Peptidase, M16
S58_RS03760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S58_RS03770	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
S58_RS03775	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
S58_RS03785	COG0356	it plays a direct role in the translocation of protons across the membrane
S58_RS03805	COG0432	Pfam Uncharacterised protein family UPF0047
S58_RS03810	COG0477	Major facilitator Superfamily
S58_RS03840	COG4977	sequence-specific DNA binding
S58_RS03840	COG1917	Cupin 2, conserved barrel domain protein
S58_RS03860	COG0583	DNA-binding transcription factor activity
S58_RS03870	COG0156	8-amino-7-oxononanoate synthase activity
S58_RS03905	COG1529	Aldehyde oxidase and xanthine dehydrogenase
S58_RS03910	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
S58_RS03915	COG2080	2 iron, 2 sulfur cluster binding
S58_RS03935	COG1414	Transcriptional regulator
S58_RS03940	COG4638	Rieske (2fe-2S)
S58_RS03950	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS03955	COG0784	Response regulator, receiver
S58_RS03955	COG4191	Histidine kinase
S58_RS03960	COG0598	Magnesium transport protein CorA
S58_RS03965	COG0747	negative chemotaxis
S58_RS04000	COG0028	Belongs to the TPP enzyme family
S58_RS04015	COG0492	ferredoxin-NADP+ reductase activity
S58_RS04020	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S58_RS04030	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
S58_RS04035	COG5328	Belongs to the UPF0262 family
S58_RS04045	COG0424	maF-like protein
S58_RS04050	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
S58_RS04060	COG0582	viral genome integration into host DNA
S58_RS04100	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
S58_RS04115	COG2176	DNA-directed DNA polymerase activity
S58_RS04120	COG4227	nucleotidyltransferase activity
S58_RS04150	COG5489	Protein of unknown function (DUF736)
S58_RS04155	COG2207	Transcriptional regulator
S58_RS04160	COG0318	PFAM AMP-dependent synthetase and ligase
S58_RS04165	COG1172	Belongs to the binding-protein-dependent transport system permease family
S58_RS04170	COG1879	ABC-type sugar transport system periplasmic component
S58_RS04175	COG1172	Belongs to the binding-protein-dependent transport system permease family
S58_RS04185	COG1129	ABC transporter
S58_RS04190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S58_RS04225	COG0367	asparagine synthase
S58_RS04265	COG2226	methyltransferase
S58_RS04355	COG1450	Type ii and iii secretion system protein
S58_RS04360	COG1459	type II secretion system
S58_RS04385	COG3156	type II secretion system protein K
S58_RS04390	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
S58_RS04410	COG3156	type II secretion system protein K
S58_RS04415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S58_RS04430	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
S58_RS04430	COG0662	Cupin 2, conserved barrel domain protein
S58_RS04505	COG4962	Type ii secretion system protein e
S58_RS04520	COG3451	type IV secretory pathway VirB4
S58_RS04530	COG3846	protein secretion by the type IV secretion system
S58_RS04555	COG3916	Acyl-homoserine-lactone synthase
S58_RS04560	COG2771	luxR family
S58_RS04570	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
S58_RS04580	COG3842	ATPase activity
S58_RS04585	COG1176	ABC-type spermidine putrescine transport system, permease component I
S58_RS04590	COG0395	ABC-type sugar transport system, permease component
S58_RS04605	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
S58_RS04610	COG0747	negative chemotaxis
S58_RS04615	COG0601	transmembrane transport
S58_RS04620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S58_RS04665	COG0154	amidase activity
S58_RS04695	COG1012	belongs to the aldehyde dehydrogenase family
S58_RS04700	COG0697	spore germination
S58_RS04710	COG2867	negative regulation of translational initiation
S58_RS04710	COG2226	methyltransferase
S58_RS04735	COG2188	Transcriptional regulator
S58_RS04750	COG2188	Transcriptional regulator
S58_RS04760	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
S58_RS04775	COG0395	ABC-type sugar transport system, permease component
S58_RS04785	COG5265	(ABC) transporter
S58_RS04800	COG1012	belongs to the aldehyde dehydrogenase family
S58_RS04830	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S58_RS04875	COG1175	transmembrane transport
S58_RS04890	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS04895	COG1069	ribulokinase activity
S58_RS04905	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
S58_RS04910	COG0297	glycogen (starch) synthase activity
S58_RS04920	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
S58_RS04925	COG1609	Transcriptional regulator
S58_RS04930	COG0024	Methionine aminopeptidase
S58_RS04945	COG0667	Aldo Keto reductase
S58_RS04975	COG2358	TRAP transporter, solute receptor (TAXI family
S58_RS04990	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS05015	COG3047	cAMP biosynthetic process
S58_RS05025	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
S58_RS05030	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S58_RS05035	COG0328	RNA-DNA hybrid ribonuclease activity
S58_RS05045	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
S58_RS05060	COG0678	peroxiredoxin activity
S58_RS05060	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
S58_RS05065	COG0318	PFAM AMP-dependent synthetase and ligase
S58_RS05070	COG1686	Belongs to the peptidase S11 family
S58_RS05075	COG1132	(ABC) transporter
S58_RS05090	COG0140	phosphoribosyl-ATP diphosphatase activity
S58_RS05095	COG1238	metal cluster binding
S58_RS05130	COG0850	regulation of cytokinetic process
S58_RS05135	COG2894	cell division
S58_RS05140	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
S58_RS05150	COG0840	transmembrane signaling receptor activity
S58_RS05160	COG0318	PFAM AMP-dependent synthetase and ligase
S58_RS05170	COG2070	2-Nitropropane dioxygenase
S58_RS05200	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
S58_RS05200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S58_RS05210	COG2223	nitrite transmembrane transporter activity
S58_RS05240	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
S58_RS05270	COG2146	nitrite reductase [NAD(P)H] activity
S58_RS05295	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS05315	COG0574	Belongs to the PEP-utilizing enzyme family
S58_RS05315	COG3848	Pyruvate phosphate dikinase
S58_RS05320	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
S58_RS05320	COG0574	Belongs to the PEP-utilizing enzyme family
S58_RS05355	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
S58_RS05365	COG0443	Heat shock 70 kDa protein
S58_RS05380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S58_RS05385	COG0596	Alpha beta hydrolase
S58_RS05405	COG0277	FAD linked oxidase domain protein
S58_RS05425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S58_RS05430	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
S58_RS05455	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
S58_RS05455	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
S58_RS05460	COG0730	response to heat
S58_RS05480	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
S58_RS05495	COG3300	MHYT domain
S58_RS05495	COG5001	Diguanylate cyclase
S58_RS05520	COG3541	Predicted nucleotidyltransferase
S58_RS05525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S58_RS05535	COG2205	protein histidine kinase activity
S58_RS05535	COG0784	Response regulator, receiver
S58_RS05535	COG2198	Histidine kinase
S58_RS05555	COG2086	electron transfer activity
S58_RS05560	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
S58_RS05565	COG1250	3-hydroxyacyl-CoA dehydrogenase
S58_RS05575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S58_RS05580	COG0165	Argininosuccinate lyase
S58_RS05595	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
S58_RS05605	COG1737	Transcriptional regulator
S58_RS05620	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S58_RS05625	COG1414	Transcriptional regulator
S58_RS05630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S58_RS05635	COG1116	anion transmembrane transporter activity
S58_RS05640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S58_RS05650	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS05655	COG4948	Mandelate Racemase Muconate Lactonizing
S58_RS05680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S58_RS05685	COG0583	DNA-binding transcription factor activity
S58_RS05690	COG2204	response regulator
S58_RS05700	COG2884	Cell division ATP-binding protein ftsE
S58_RS05730	COG0287	Prephenate dehydrogenase
S58_RS05735	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
S58_RS05745	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
S58_RS05750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
S58_RS05750	COG2813	Specifically methylates the guanine in position
S58_RS05785	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S58_RS05785	COG1648	precorrin-2 dehydrogenase activity
S58_RS05795	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S58_RS05805	COG0175	sulfate reduction
S58_RS05810	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
S58_RS05815	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
S58_RS05820	COG4208	sulfate ABC transporter
S58_RS05825	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
S58_RS05840	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS05845	COG4095	Psort location CytoplasmicMembrane, score
S58_RS05850	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
S58_RS05870	COG1678	Uncharacterized ACR, COG1678
S58_RS05880	COG2133	pyrroloquinoline quinone binding
S58_RS05885	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS05890	COG3237	CsbD-like
S58_RS05900	COG2951	lytic endotransglycosylase activity
S58_RS05905	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S58_RS05910	COG5001	Diguanylate cyclase
S58_RS05910	COG3706	GGDEF domain
S58_RS05910	COG2203	Gaf domain
S58_RS05910	COG4251	negative regulation of phosphorylation
S58_RS05920	COG0747	negative chemotaxis
S58_RS05930	COG0601	transmembrane transport
S58_RS05935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S58_RS05940	COG0444	Belongs to the ABC transporter superfamily
S58_RS05945	COG4608	Belongs to the ABC transporter superfamily
S58_RS05955	COG0318	PFAM AMP-dependent synthetase and ligase
S58_RS05965	COG3300	MHYT domain
S58_RS05965	COG5001	Diguanylate cyclase
S58_RS05970	COG0604	alcohol dehydrogenase
S58_RS05970	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS05970	COG3321	synthase
S58_RS05985	COG0254	rRNA binding
S58_RS05990	COG1132	(ABC) transporter
S58_RS06020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S58_RS06025	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S58_RS06035	COG0483	inositol monophosphate 1-phosphatase activity
S58_RS06050	COG3588	fructose-bisphosphate aldolase
S58_RS06065	COG0126	phosphoglycerate kinase activity
S58_RS06075	COG0514	ATP-dependent DNA helicase (RecQ)
S58_RS06115	COG0625	glutathione transferase activity
S58_RS06135	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
S58_RS06140	COG1692	metallophosphoesterase
S58_RS06145	COG0840	transmembrane signaling receptor activity
S58_RS06150	COG3290	protein histidine kinase activity
S58_RS06150	COG0840	transmembrane signaling receptor activity
S58_RS06155	COG0217	transcriptional regulatory protein
S58_RS06160	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
S58_RS06165	COG0632	four-way junction helicase activity
S58_RS06175	COG2255	four-way junction helicase activity
S58_RS06185	COG1408	metallophosphoesterase
S58_RS06190	COG0824	Thioesterase
S58_RS06195	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
S58_RS06195	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
S58_RS06200	COG0625	glutathione transferase activity
S58_RS06205	COG1309	transcriptional regulator
S58_RS06210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S58_RS06220	COG3795	YCII-related domain
S58_RS06225	COG4941	Belongs to the sigma-70 factor family
S58_RS06235	COG2764	glyoxalase bleomycin resistance protein dioxygenase
S58_RS06245	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS06260	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
S58_RS06275	COG3795	YCII-related domain
S58_RS06310	COG0848	biopolymer transport protein
S58_RS06320	COG0823	Involved in the tonB-independent uptake of proteins
S58_RS06325	COG5001	Diguanylate cyclase
S58_RS06345	COG2885	chlorophyll binding
S58_RS06355	COG0037	tRNA processing
S58_RS06360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S58_RS06375	COG1309	transcriptional regulator
S58_RS06385	COG0469	pyruvate kinase activity
S58_RS06400	COG3750	Belongs to the UPF0335 family
S58_RS06410	COG2989	Protein conserved in bacteria
S58_RS06415	COG2204	response regulator
S58_RS06420	COG1164	Oligoendopeptidase f
S58_RS06465	COG0387	Pfam Sodium calcium exchanger
S58_RS06480	COG0828	Belongs to the bacterial ribosomal protein bS21 family
S58_RS06485	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
S58_RS06490	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
S58_RS06495	COG3447	MASE1 domain protein
S58_RS06495	COG5001	Diguanylate cyclase
S58_RS06495	COG5002	protein histidine kinase activity
S58_RS06520	COG0579	oxidoreductase
S58_RS06525	COG3300	MHYT domain
S58_RS06525	COG5001	Diguanylate cyclase
S58_RS06535	COG3842	ATPase activity
S58_RS06540	COG1176	ABC-type spermidine putrescine transport system, permease component I
S58_RS06545	COG1177	transmembrane transport
S58_RS06560	COG1175	transmembrane transport
S58_RS06605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S58_RS06615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S58_RS06625	COG2205	protein histidine kinase activity
S58_RS06645	COG1192	Involved in chromosome partitioning
S58_RS06650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S58_RS06655	COG0583	DNA-binding transcription factor activity
S58_RS06660	COG0492	ferredoxin-NADP+ reductase activity
S58_RS06665	COG1522	sequence-specific DNA binding
S58_RS06675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S58_RS06680	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S58_RS06705	COG0640	Transcriptional regulator
S58_RS06715	COG0747	negative chemotaxis
S58_RS06720	COG0505	Belongs to the CarA family
S58_RS06730	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S58_RS06755	COG0640	Transcriptional regulator
S58_RS06760	COG1280	lysine exporter protein (LysE YggA)
S58_RS06780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S58_RS06800	COG0358	DNA primase activity
S58_RS06805	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
S58_RS06810	COG3739	integral membrane protein
S58_RS06870	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
S58_RS06875	COG0564	pseudouridine synthase activity
S58_RS06905	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS06915	COG3258	Cytochrome c
S58_RS06935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S58_RS06960	COG0596	Alpha beta hydrolase
S58_RS06970	COG0783	Belongs to the Dps family
S58_RS06985	COG0596	Alpha beta hydrolase
S58_RS07015	COG0596	Alpha beta hydrolase
S58_RS07035	COG1764	response to oxidative stress
S58_RS07040	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S58_RS07050	COG3181	Tripartite tricarboxylate transporter family receptor
S58_RS07125	COG1733	regulation of RNA biosynthetic process
S58_RS07130	COG0183	Belongs to the thiolase family
S58_RS07140	COG3851	Histidine kinase
S58_RS07160	COG0662	Cupin 2, conserved barrel domain protein
S58_RS07165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S58_RS07180	COG3284	Transcriptional regulator
S58_RS07185	COG1063	alcohol dehydrogenase
S58_RS07230	COG0459	protein refolding
S58_RS07235	COG3284	Transcriptional regulator
S58_RS07240	COG0745	RESPONSE REGULATOR receiver
S58_RS07265	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
S58_RS07290	COG0753	catalase activity
S58_RS07345	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S58_RS07390	COG0840	transmembrane signaling receptor activity
S58_RS07395	COG2204	response regulator
S58_RS07400	COG1012	belongs to the aldehyde dehydrogenase family
S58_RS07420	COG1879	ABC-type sugar transport system periplasmic component
S58_RS07425	COG1172	Belongs to the binding-protein-dependent transport system permease family
S58_RS07435	COG1070	Carbohydrate kinase
S58_RS07445	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS07475	COG5001	Diguanylate cyclase
S58_RS07480	COG0484	heat shock protein binding
S58_RS07485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S58_RS07510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S58_RS07520	COG2205	protein histidine kinase activity
S58_RS07535	COG1704	LemA family
S58_RS07540	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
S58_RS07550	COG2378	regulation of single-species biofilm formation
S58_RS07570	COG2271	Major facilitator Superfamily
S58_RS07595	COG0784	Response regulator, receiver
S58_RS07595	COG4191	Histidine kinase
S58_RS07630	COG1278	Cold shock
S58_RS07640	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
S58_RS07645	COG3768	UPF0283 membrane protein
S58_RS07650	COG3106	COG3106 Predicted ATPase
S58_RS07655	COG1272	protein, Hemolysin III
S58_RS07695	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
S58_RS07700	COG1804	L-carnitine dehydratase bile acid-inducible protein F
S58_RS07705	COG1960	acyl-CoA dehydrogenase activity
S58_RS07735	COG1960	acyl-CoA dehydrogenase activity
S58_RS07745	COG0501	Belongs to the peptidase M48B family
S58_RS07755	COG1376	ErfK ybiS ycfS ynhG family protein
S58_RS07760	COG0028	Belongs to the TPP enzyme family
S58_RS07805	COG0583	DNA-binding transcription factor activity
S58_RS07810	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S58_RS07860	COG3166	PFAM Fimbrial assembly family protein
S58_RS07895	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
S58_RS07905	COG1450	Type ii and iii secretion system protein
S58_RS07920	COG1262	PFAM Formylglycine-generating sulfatase enzyme
S58_RS07935	COG1879	ABC-type sugar transport system periplasmic component
S58_RS07940	COG1172	Belongs to the binding-protein-dependent transport system permease family
S58_RS07945	COG1172	Belongs to the binding-protein-dependent transport system permease family
S58_RS07950	COG1129	ABC transporter
S58_RS07955	COG0277	FAD linked oxidase domain protein
S58_RS07960	COG3485	protocatechuate 3,4-dioxygenase
S58_RS07980	COG0583	DNA-binding transcription factor activity
S58_RS08025	COG0592	DNA-directed DNA polymerase activity
S58_RS08060	COG1061	Type III restriction enzyme res subunit
S58_RS08360	COG0643	Histidine kinase
S58_RS08360	COG0784	Response regulator, receiver
S58_RS08360	COG2198	Histidine kinase
S58_RS08365	COG0835	chemotaxis
S58_RS08370	COG0643	Histidine kinase
S58_RS08370	COG0784	Response regulator, receiver
S58_RS08370	COG2198	Histidine kinase
S58_RS08375	COG2201	protein-glutamate methylesterase activity
S58_RS08385	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
S58_RS08390	COG4251	negative regulation of phosphorylation
S58_RS08395	COG3920	Histidine kinase
S58_RS08395	COG2202	Pas domain
S58_RS08400	COG0784	Response regulator, receiver
S58_RS08405	COG0754	glutathionylspermidine amidase activity
S58_RS08415	COG3766	membrane
S58_RS08420	COG1802	Transcriptional regulator
S58_RS08435	COG1116	anion transmembrane transporter activity
S58_RS08475	COG1595	DNA-templated transcription, initiation
S58_RS08490	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
S58_RS08510	COG0789	Transcriptional regulator
S58_RS08560	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS08565	COG0583	DNA-binding transcription factor activity
S58_RS08590	COG2358	TRAP transporter, solute receptor (TAXI family
S58_RS08605	COG3483	tryptophan 2,3-dioxygenase activity
S58_RS08615	COG0640	Transcriptional regulator
S58_RS08620	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
S58_RS08625	COG0405	Gamma-glutamyltransferase
S58_RS08645	COG1126	abc transporter atp-binding protein
S58_RS08655	COG1177	transmembrane transport
S58_RS08660	COG3842	ATPase activity
S58_RS08675	COG1228	amidohydrolase
S58_RS08690	COG3842	ATPase activity
S58_RS08695	COG1176	ABC-type spermidine putrescine transport system, permease component I
S58_RS08700	COG1177	transmembrane transport
S58_RS08765	COG0235	Class ii aldolase
S58_RS08770	COG2721	sulfolactate sulfo-lyase activity
S58_RS08775	COG1012	belongs to the aldehyde dehydrogenase family
S58_RS08780	COG4948	Mandelate Racemase Muconate Lactonizing
S58_RS08785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S58_RS08790	COG0583	DNA-binding transcription factor activity
S58_RS08810	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
S58_RS08820	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
S58_RS08825	COG0366	Alpha amylase catalytic
S58_RS08830	COG1640	4-alpha-glucanotransferase
S58_RS08835	COG3387	PFAM Glycoside hydrolase 15-related
S58_RS08845	COG3265	gluconokinase activity
S58_RS08850	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
S58_RS08855	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
S58_RS08860	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
S58_RS08870	COG2766	serine protein kinase
S58_RS08875	COG2718	Belongs to the UPF0229 family
S58_RS08880	COG2719	SpoVR family
S58_RS08895	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
S58_RS08895	COG0674	pyruvate-flavodoxin oxidoreductase activity
S58_RS08915	COG0535	radical SAM domain protein
S58_RS08920	COG0535	radical SAM domain protein
S58_RS08925	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
S58_RS08930	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
S58_RS08950	COG2706	6-phosphogluconolactonase activity
S58_RS08955	COG0154	amidase activity
S58_RS08960	COG0386	Belongs to the glutathione peroxidase family
S58_RS09035	COG2072	flavoprotein involved in K transport
S58_RS09055	COG0625	glutathione transferase activity
S58_RS09085	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
S58_RS09115	COG0784	Response regulator, receiver
S58_RS09115	COG4191	Histidine kinase
S58_RS09120	COG3511	phospholipase C
S58_RS09135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S58_RS09155	COG2897	thiosulfate sulfurtransferase activity
S58_RS09165	COG1376	ErfK ybiS ycfS ynhG family protein
S58_RS09170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S58_RS09255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
S58_RS09270	COG2204	response regulator
S58_RS09285	COG0625	glutathione transferase activity
S58_RS09300	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
S58_RS09300	COG2755	lipolytic protein G-D-S-L family
S58_RS09310	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
S58_RS09315	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
S58_RS09325	COG2022	thiamine diphosphate biosynthetic process
S58_RS09380	COG1388	LysM domain
S58_RS09380	COG1376	ErfK ybiS ycfS ynhG family protein
S58_RS09385	COG0438	transferase activity, transferring glycosyl groups
S58_RS09405	COG0688	phosphatidylethanolamine metabolic process
S58_RS09410	COG0494	nUDIX hydrolase
S58_RS09410	COG0406	alpha-ribazole phosphatase activity
S58_RS09415	COG2080	2 iron, 2 sulfur cluster binding
S58_RS09420	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
S58_RS09425	COG1529	Aldehyde oxidase and xanthine dehydrogenase
S58_RS09440	COG1136	(ABC) transporter
S58_RS09440	COG0577	efflux transmembrane transporter activity
S58_RS09445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S58_RS09485	COG0864	Transcriptional regulator
S58_RS09490	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
S58_RS09525	COG5265	(ABC) transporter
S58_RS09530	COG3795	YCII-related domain
S58_RS09540	COG3023	N-Acetylmuramoyl-L-alanine amidase
S58_RS09545	COG0275	rRNA processing
S58_RS09560	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
S58_RS09565	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
S58_RS09570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S58_RS09575	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S58_RS09585	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S58_RS09590	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
S58_RS09595	COG0812	UDP-N-acetylmuramate dehydrogenase activity
S58_RS09600	COG1181	Belongs to the D-alanine--D-alanine ligase family
S58_RS09605	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
S58_RS09610	COG0849	cell division
S58_RS09615	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
S58_RS09630	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
S58_RS09635	COG0497	DNA recombination
S58_RS09640	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
S58_RS09645	COG2814	Major facilitator Superfamily
S58_RS09650	COG0006	proline dipeptidase activity
S58_RS09650	COG0006	proline dipeptidase activity
S58_RS09660	COG2264	protein methyltransferase activity
S58_RS09680	COG1879	ABC-type sugar transport system periplasmic component
S58_RS09685	COG1129	ABC transporter
S58_RS09690	COG1172	Belongs to the binding-protein-dependent transport system permease family
S58_RS09705	COG0842	Transport permease protein
S58_RS09710	COG1131	(ABC) transporter
S58_RS09720	COG1376	ErfK ybiS ycfS ynhG family protein
S58_RS09730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S58_RS09750	COG0210	DNA helicase
S58_RS09800	COG0277	FAD linked oxidase domain protein
S58_RS09820	COG0583	DNA-binding transcription factor activity
S58_RS09825	COG2259	Doxx family
S58_RS09830	COG3384	dioxygenase
S58_RS09840	COG2271	Major facilitator Superfamily
S58_RS09845	COG2124	cytochrome p450
S58_RS09855	COG0583	DNA-binding transcription factor activity
S58_RS09860	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
S58_RS09890	COG3185	4-Hydroxyphenylpyruvate dioxygenase
S58_RS09890	COG1082	Xylose isomerase domain protein TIM barrel
S58_RS09895	COG0583	DNA-binding transcription factor activity
S58_RS09900	COG2249	NAD(P)H dehydrogenase (quinone) activity
S58_RS09920	COG0114	fumarate hydratase activity
S58_RS09950	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
S58_RS09965	COG0330	HflC and HflK could
S58_RS09970	COG0330	HflC and HflK could
S58_RS09985	COG0583	DNA-binding transcription factor activity
S58_RS10005	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
S58_RS10010	COG0028	Belongs to the TPP enzyme family
S58_RS10020	COG0440	acetolactate synthase activity
S58_RS10035	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
S58_RS10075	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS10085	COG2197	response regulator
S58_RS10115	COG1804	L-carnitine dehydratase bile acid-inducible protein F
S58_RS10140	COG1335	isochorismatase
S58_RS10150	COG1174	glycine betaine transport
S58_RS10165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S58_RS10180	COG2326	polyphosphate kinase activity
S58_RS10185	COG5001	Diguanylate cyclase
S58_RS10185	COG3300	MHYT domain
S58_RS10205	COG2814	Major facilitator Superfamily
S58_RS10210	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
S58_RS10215	COG2340	Cysteine-rich secretory protein family
S58_RS10250	COG4774	siderophore transport
S58_RS10290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S58_RS10330	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
S58_RS10380	COG1529	Aldehyde oxidase and xanthine dehydrogenase
S58_RS10405	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS10405	COG0604	alcohol dehydrogenase
S58_RS10405	COG3321	synthase
S58_RS10430	COG0183	Belongs to the thiolase family
S58_RS10450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
S58_RS10455	COG1960	acyl-CoA dehydrogenase activity
S58_RS10460	COG2186	Transcriptional regulator
S58_RS10465	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
S58_RS10470	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
S58_RS10495	COG1960	acyl-CoA dehydrogenase activity
S58_RS10500	COG1960	acyl-CoA dehydrogenase activity
S58_RS10520	COG2030	dehydratase
S58_RS10565	COG0673	inositol 2-dehydrogenase activity
S58_RS10570	COG3597	protein domain associated with
S58_RS10595	COG0367	asparagine synthase
S58_RS10605	COG1509	lysine 2,3-aminomutase activity
S58_RS10625	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
S58_RS10625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
S58_RS10630	COG4232	protein-disulfide reductase activity
S58_RS10655	COG1116	anion transmembrane transporter activity
S58_RS10660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S58_RS10665	COG4521	taurine ABC transporter
S58_RS10670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S58_RS10685	COG1053	succinate dehydrogenase
S58_RS10710	COG3842	ATPase activity
S58_RS10715	COG1176	ABC-type spermidine putrescine transport system, permease component I
S58_RS10720	COG1177	transmembrane transport
S58_RS10745	COG0251	oxidation-reduction process
S58_RS10750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S58_RS10765	COG0066	3-isopropylmalate dehydratase activity
S58_RS10770	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
S58_RS10780	COG0683	leucine binding
S58_RS10785	COG0559	Belongs to the binding-protein-dependent transport system permease family
S58_RS10830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S58_RS10835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S58_RS10845	COG1802	Transcriptional regulator
S58_RS10855	COG0179	Fumarylacetoacetate (FAA) hydrolase
S58_RS10860	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
S58_RS10900	COG3791	Glutathione-dependent formaldehyde-activating
S58_RS10905	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
S58_RS10965	COG1116	anion transmembrane transporter activity
S58_RS10975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S58_RS11015	COG1131	(ABC) transporter
S58_RS11035	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
S58_RS11060	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS11075	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS11080	COG3604	Transcriptional regulator
S58_RS11085	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
S58_RS11090	COG0719	Fe-S assembly protein
S58_RS11095	COG0396	ATPase activity
S58_RS11100	COG0719	Fe-S assembly protein
S58_RS11105	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S58_RS11110	COG2166	iron-sulfur cluster assembly
S58_RS11120	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
S58_RS11130	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
S58_RS11135	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
S58_RS11140	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
S58_RS11155	COG5420	small protein containing a coiled-coil domain
S58_RS11175	COG2897	thiosulfate sulfurtransferase activity
S58_RS11195	COG0316	Belongs to the HesB IscA family
S58_RS11205	COG1104	cysteine desulfurase activity
S58_RS11210	COG5554	nitrogen fixation
S58_RS11225	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
S58_RS11245	COG5554	nitrogen fixation
S58_RS11265	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S58_RS11285	COG2346	COG2346, Truncated hemoglobins
S58_RS11300	COG2151	metal-sulfur cluster biosynthetic enzyme
S58_RS11315	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
S58_RS11320	COG3411	Ferredoxin
S58_RS11335	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
S58_RS11365	COG2086	electron transfer activity
S58_RS11370	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
S58_RS11375	COG0644	oxidoreductase
S58_RS11380	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
S58_RS11390	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
S58_RS11390	COG1618	nucleotide phosphatase activity, acting on free nucleotides
S58_RS11410	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S58_RS11415	COG0450	alkyl hydroperoxide reductase
S58_RS11420	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS11425	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
S58_RS11430	COG3454	Phosphonate metabolism
S58_RS11440	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
S58_RS11455	COG3639	organic phosphonate transmembrane transporter activity
S58_RS11475	COG3842	ATPase activity
S58_RS11485	COG2188	Transcriptional regulator
S58_RS11490	COG3624	Phosphonate C-P lyase system protein PhnG
S58_RS11495	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
S58_RS11500	COG3626	phosphonate metabolism
S58_RS11505	COG3627	carbon phosphorus lyase activity
S58_RS11510	COG4107	phosphonate C-P lyase system protein PhnK
S58_RS11515	COG4778	phosphonate C-P lyase system protein PhnL
S58_RS11520	COG3454	Phosphonate metabolism
S58_RS11525	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
S58_RS11590	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
S58_RS11615	COG3403	YqcI/YcgG family
S58_RS11630	COG4977	sequence-specific DNA binding
S58_RS11645	COG2010	Cytochrome c
S58_RS11675	COG0281	malic enzyme
S58_RS11725	COG1804	L-carnitine dehydratase bile acid-inducible protein F
S58_RS11740	COG3243	poly(R)-hydroxyalkanoic acid synthase
S58_RS11755	COG0045	succinate-CoA ligase (ADP-forming) activity
S58_RS11755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S58_RS11755	COG1042	CoA-binding domain protein
S58_RS11775	COG1127	ABC transporter
S58_RS11780	COG3218	ABC-type transport auxiliary lipoprotein component
S58_RS11780	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
S58_RS11790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S58_RS11810	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
S58_RS11815	COG1802	Transcriptional regulator
S58_RS11820	COG0243	molybdopterin cofactor binding
S58_RS11835	COG1024	Enoyl-CoA hydratase
S58_RS11840	COG2311	Membrane
S58_RS11865	COG0247	lactate metabolic process
S58_RS11865	COG0277	FAD linked oxidase domain protein
S58_RS11875	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
S58_RS11880	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
S58_RS11885	COG1024	Enoyl-CoA hydratase
S58_RS11890	COG3181	Tripartite tricarboxylate transporter family receptor
S58_RS11910	COG1804	L-carnitine dehydratase bile acid-inducible protein F
S58_RS11915	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
S58_RS11935	COG0559	Belongs to the binding-protein-dependent transport system permease family
S58_RS11940	COG2852	Protein conserved in bacteria
S58_RS11945	COG1022	Amp-dependent synthetase and ligase
S58_RS11960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S58_RS12005	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S58_RS12040	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
S58_RS12045	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
S58_RS12095	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
S58_RS12140	COG4964	Belongs to the GSP D family
S58_RS12165	COG1132	(ABC) transporter
S58_RS12180	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
S58_RS12185	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
S58_RS12190	COG0859	PFAM glycosyl transferase family 9
S58_RS12200	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
S58_RS12200	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
S58_RS12210	COG1086	Polysaccharide biosynthesis protein
S58_RS12220	COG0438	transferase activity, transferring glycosyl groups
S58_RS12255	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS12285	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
S58_RS12285	COG2755	lipolytic protein G-D-S-L family
S58_RS12295	COG2755	lipolytic protein G-D-S-L family
S58_RS12295	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
S58_RS12330	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
S58_RS12335	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
S58_RS12340	COG3959	Transketolase, thiamine diphosphate binding domain
S58_RS12350	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
S58_RS12355	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S58_RS12365	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
S58_RS12365	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
S58_RS12380	COG1696	Membrane protein involved in D-alanine export
S58_RS12395	COG0367	asparagine synthase
S58_RS12460	COG0728	peptidoglycan biosynthetic process
S58_RS12470	COG3909	cytochrome
S58_RS12475	COG2010	Cytochrome c
S58_RS12485	COG3300	MHYT domain
S58_RS12485	COG5001	Diguanylate cyclase
S58_RS12500	COG0351	phosphomethylpyrimidine kinase
S58_RS12535	COG1574	metal-dependent hydrolase with the TIM-barrel fold
S58_RS12560	COG0179	Fumarylacetoacetate (FAA) hydrolase
S58_RS12570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S58_RS12580	COG1802	Transcriptional regulator
S58_RS12585	COG1309	transcriptional regulator
S58_RS12595	COG2200	EAL domain
S58_RS12595	COG2771	luxR family
S58_RS12625	COG0798	PFAM Bile acid sodium symporter
S58_RS12650	COG3038	cytochrome b561
S58_RS12715	COG2814	Major facilitator Superfamily
S58_RS12720	COG4948	Mandelate Racemase Muconate Lactonizing
S58_RS12725	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
S58_RS12735	COG3218	ABC-type transport auxiliary lipoprotein component
S58_RS12735	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
S58_RS12750	COG0633	Ferredoxin
S58_RS12760	COG0492	ferredoxin-NADP+ reductase activity
S58_RS12780	COG3685	Protein conserved in bacteria
S58_RS12825	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S58_RS12830	COG1749	Flagellar hook protein flgE
S58_RS12860	COG0076	glutamate decarboxylase activity
S58_RS12870	COG5443	negative regulation of bacterial-type flagellum assembly
S58_RS12910	COG1706	bacterial-type flagellum-dependent cell motility
S58_RS12920	COG1733	regulation of RNA biosynthetic process
S58_RS12965	COG4786	Flagellar basal body rod
S58_RS12970	COG4786	Flagellar basal body rod
S58_RS13005	COG0789	Transcriptional regulator
S58_RS13015	COG1338	Plays a role in the flagellum-specific transport system
S58_RS13030	COG1558	bacterial-type flagellum-dependent cell motility
S58_RS13035	COG1677	Flagellar hook-basal body complex protein FliE
S58_RS13040	COG1987	bacterial-type flagellum assembly
S58_RS13045	COG1684	flagellar biosynthetic protein fliR
S58_RS13050	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
S58_RS13100	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
S58_RS13100	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
S58_RS13105	COG2030	dehydratase
S58_RS13120	COG2917	probably involved in intracellular septation
S58_RS13200	COG4993	Dehydrogenase
S58_RS13235	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
S58_RS13245	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S58_RS13245	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S58_RS13250	COG0509	glycine decarboxylation via glycine cleavage system
S58_RS13255	COG0404	The glycine cleavage system catalyzes the degradation of glycine
S58_RS13260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
S58_RS13265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S58_RS13275	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
S58_RS13280	COG3383	formate dehydrogenase (NAD+) activity
S58_RS13295	COG0583	DNA-binding transcription factor activity
S58_RS13305	COG1755	Isoprenylcysteine carboxyl methyltransferase
S58_RS13310	COG2202	Pas domain
S58_RS13310	COG2205	protein histidine kinase activity
S58_RS13320	COG1063	alcohol dehydrogenase
S58_RS13355	COG0596	Alpha beta hydrolase
S58_RS13360	COG1309	transcriptional regulator
S58_RS13385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S58_RS13395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S58_RS13455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
S58_RS13465	COG1802	Transcriptional regulator
S58_RS13480	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
S58_RS13485	COG3960	tartronate-semialdehyde synthase activity
S58_RS13490	COG3622	Belongs to the hyi family
S58_RS13495	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
S58_RS13510	COG0583	DNA-binding transcription factor activity
S58_RS13580	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S58_RS13595	COG1982	Orn Lys Arg decarboxylase major
S58_RS13600	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
S58_RS13610	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
S58_RS13620	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
S58_RS13625	COG1492	cobalamin metabolic process
S58_RS13675	COG2099	Precorrin-6x reductase
S58_RS13690	COG2875	Belongs to the precorrin methyltransferase family
S58_RS13695	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
S58_RS13700	COG1797	cobyrinic acid a,c-diamide synthase activity
S58_RS13705	COG0778	Nitroreductase
S58_RS13720	COG1595	DNA-templated transcription, initiation
S58_RS13725	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S58_RS13730	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
S58_RS13750	COG1749	Flagellar hook protein flgE
S58_RS13775	COG0300	oxidoreductase activity
S58_RS13780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S58_RS13870	COG0559	Belongs to the binding-protein-dependent transport system permease family
S58_RS13980	COG4310	Domain of unknown function (DUF2172)
S58_RS14000	COG0673	inositol 2-dehydrogenase activity
S58_RS14010	COG0367	asparagine synthase
S58_RS14030	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
S58_RS14030	COG2755	lipolytic protein G-D-S-L family
S58_RS14035	COG1215	transferase activity, transferring glycosyl groups
S58_RS14045	COG3307	-O-antigen
S58_RS14065	COG3206	protein involved in exopolysaccharide biosynthesis
S58_RS14065	COG0489	protein tyrosine kinase activity
S58_RS14075	COG0647	UMP catabolic process
S58_RS14080	COG1070	Carbohydrate kinase
S58_RS14090	COG1653	transport
S58_RS14095	COG1175	transmembrane transport
S58_RS14110	COG3842	ATPase activity
S58_RS14125	COG0235	Class ii aldolase
S58_RS14135	COG1172	Belongs to the binding-protein-dependent transport system permease family
S58_RS14140	COG1172	Belongs to the binding-protein-dependent transport system permease family
S58_RS14145	COG1129	ABC transporter
S58_RS14150	COG1879	ABC-type sugar transport system periplasmic component
S58_RS14155	COG1609	Transcriptional regulator
S58_RS14190	COG5564	TIM-barrel signal transduction protein
S58_RS14195	COG2268	Band 7 protein
S58_RS14195	COG2268	Band 7 protein
S58_RS14215	COG2080	2 iron, 2 sulfur cluster binding
S58_RS14240	COG3618	amidohydrolase
S58_RS14250	COG3386	PFAM SMP-30 Gluconolaconase
S58_RS14255	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S58_RS14260	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
S58_RS14270	COG2201	protein-glutamate methylesterase activity
S58_RS14315	COG0318	PFAM AMP-dependent synthetase and ligase
S58_RS14345	COG0534	Mate efflux family protein
S58_RS14350	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S58_RS14355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S58_RS14380	COG0776	regulation of translation
S58_RS14385	COG1234	tRNA 3'-trailer cleavage
S58_RS14395	COG0583	DNA-binding transcription factor activity
S58_RS14405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
S58_RS14415	COG2202	Pas domain
S58_RS14415	COG2205	protein histidine kinase activity
S58_RS14430	COG2084	Dehydrogenase
S58_RS14435	COG0346	lactoylglutathione lyase activity
S58_RS14445	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
S58_RS14450	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
S58_RS14455	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
S58_RS14485	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
S58_RS14495	COG0546	phosphoglycolate phosphatase activity
S58_RS14500	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
S58_RS14560	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
S58_RS14565	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
S58_RS14585	COG0215	cysteine-tRNA ligase activity
S58_RS14595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S58_RS14610	COG5265	(ABC) transporter
S58_RS14615	COG0688	phosphatidylethanolamine metabolic process
S58_RS14640	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
S58_RS14650	COG3158	transport of potassium into the cell
S58_RS14655	COG3158	transport of potassium into the cell
S58_RS14660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S58_RS14665	COG0436	Aminotransferase
S58_RS14670	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
S58_RS14685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S58_RS14700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S58_RS14720	COG1566	PFAM secretion protein HlyD family protein
S58_RS14730	COG1289	transmembrane transporter activity
S58_RS14745	COG0071	Belongs to the small heat shock protein (HSP20) family
S58_RS14750	COG3384	dioxygenase
S58_RS14755	COG0494	nUDIX hydrolase
S58_RS14785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S58_RS14805	COG4774	siderophore transport
S58_RS14810	COG3128	pkhd-type hydroxylase
S58_RS14820	COG0848	biopolymer transport protein
S58_RS14835	COG1994	Peptidase M50
S58_RS14860	COG1733	regulation of RNA biosynthetic process
S58_RS14865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S58_RS14870	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
S58_RS14885	COG0564	pseudouridine synthase activity
S58_RS14905	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
S58_RS14935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S58_RS14960	COG0640	Transcriptional regulator
S58_RS14985	COG2860	membrane
S58_RS15020	COG2030	dehydratase
S58_RS15025	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS15030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S58_RS15110	COG4235	cytochrome complex assembly
S58_RS15115	COG3088	subunit of a heme lyase
S58_RS15120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S58_RS15125	COG1138	Cytochrome C-type biogenesis protein
S58_RS15160	COG0156	8-amino-7-oxononanoate synthase activity
S58_RS15185	COG0415	Belongs to the DNA photolyase family
S58_RS15190	COG0840	transmembrane signaling receptor activity
S58_RS15190	COG3290	protein histidine kinase activity
S58_RS15225	COG0513	Belongs to the DEAD box helicase family
S58_RS15235	COG0450	alkyl hydroperoxide reductase
S58_RS15250	COG3685	Protein conserved in bacteria
S58_RS15265	COG0471	metal ion transport
S58_RS15265	COG3273	potassium ion transport
S58_RS15290	COG4191	Histidine kinase
S58_RS15310	COG4770	biotin carboxylase activity
S58_RS15315	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
S58_RS15320	COG1254	Belongs to the acylphosphatase family
S58_RS15325	COG2226	methyltransferase
S58_RS15340	COG1090	epimerase
S58_RS15360	COG0321	lipoyl(octanoyl) transferase activity
S58_RS15400	COG2205	protein histidine kinase activity
S58_RS15455	COG4191	Histidine kinase
S58_RS15455	COG0784	Response regulator, receiver
S58_RS15475	COG0583	DNA-binding transcription factor activity
S58_RS15495	COG0154	amidase activity
S58_RS15505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S58_RS15515	COG0726	polysaccharide deacetylase
S58_RS15525	COG2239	Acts as a magnesium transporter
S58_RS15535	COG0656	L-ascorbic acid biosynthetic process
S58_RS15545	COG0625	glutathione transferase activity
S58_RS15570	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
S58_RS15575	COG1192	Involved in chromosome partitioning
S58_RS15595	COG1686	Belongs to the peptidase S11 family
S58_RS15610	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
S58_RS15625	COG2814	Major facilitator Superfamily
S58_RS15640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S58_RS15680	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
S58_RS15685	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
S58_RS15695	COG0537	adenosine 5'-monophosphoramidase activity
S58_RS15720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S58_RS15730	COG0784	Response regulator, receiver
S58_RS15770	COG2205	protein histidine kinase activity
S58_RS15775	COG0745	RESPONSE REGULATOR receiver
S58_RS15790	COG3290	protein histidine kinase activity
S58_RS15790	COG0840	transmembrane signaling receptor activity
S58_RS15795	COG0267	Belongs to the bacterial ribosomal protein bL33 family
S58_RS15810	COG0251	oxidation-reduction process
S58_RS15825	COG0557	exoribonuclease II activity
S58_RS15830	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S58_RS15845	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS15850	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S58_RS15855	COG1733	regulation of RNA biosynthetic process
S58_RS15860	COG0758	DNA mediated transformation
S58_RS15870	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
S58_RS15875	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S58_RS15880	COG0540	Belongs to the ATCase OTCase family
S58_RS15890	COG1960	acyl-CoA dehydrogenase activity
S58_RS15905	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
S58_RS15910	COG0488	(ABC) transporter
S58_RS15920	COG0583	DNA-binding transcription factor activity
S58_RS15925	COG2070	2-Nitropropane dioxygenase
S58_RS15930	COG2070	2-Nitropropane dioxygenase
S58_RS15935	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S58_RS15945	COG0154	amidase activity
S58_RS15960	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S58_RS16005	COG0741	lytic transglycosylase activity
S58_RS16010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S58_RS16015	COG1970	mechanosensitive ion channel activity
S58_RS16020	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
S58_RS16030	COG1573	uracil-dna glycosylase
S58_RS16040	COG1758	RNA polymerase activity
S58_RS16050	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
S58_RS16055	COG0736	holo-[acyl-carrier-protein] synthase activity
S58_RS16060	COG0681	Belongs to the peptidase S26 family
S58_RS16065	COG0571	ribonuclease III activity
S58_RS16070	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
S58_RS16080	COG1381	Involved in DNA repair and RecF pathway recombination
S58_RS16085	COG0435	Glutathione S-transferase
S58_RS16100	COG0028	Belongs to the TPP enzyme family
S58_RS16120	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS16125	COG1053	succinate dehydrogenase
S58_RS16155	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S58_RS16165	COG2059	Chromate
S58_RS16200	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
S58_RS16205	COG1914	H( )-stimulated, divalent metal cation uptake system
S58_RS16210	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
S58_RS16220	COG0113	porphobilinogen synthase activity
S58_RS16250	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
S58_RS16255	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
S58_RS16260	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S58_RS16260	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S58_RS16270	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
S58_RS16275	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S58_RS16280	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
S58_RS16285	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
S58_RS16300	COG3181	Tripartite tricarboxylate transporter family receptor
S58_RS16320	COG0416	fatty acid biosynthetic process
S58_RS16325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S58_RS16330	COG0776	regulation of translation
S58_RS16350	COG4716	Myosin-crossreactive antigen
S58_RS16355	COG4716	Myosin-crossreactive antigen
S58_RS16360	COG3845	ABC transporter
S58_RS16370	COG1079	Belongs to the binding-protein-dependent transport system permease family
S58_RS16375	COG4603	Belongs to the binding-protein-dependent transport system permease family
S58_RS16425	COG3268	Saccharopine dehydrogenase
S58_RS16430	COG3268	Saccharopine dehydrogenase
S58_RS16450	COG0489	protein tyrosine kinase activity
S58_RS16450	COG3206	protein involved in exopolysaccharide biosynthesis
S58_RS16470	COG1612	heme a metabolic process
S58_RS16520	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
S58_RS16525	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
S58_RS16530	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
S58_RS16555	COG1473	amidohydrolase
S58_RS16565	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
S58_RS16585	COG0174	glutamine synthetase
S58_RS16590	COG0347	Belongs to the P(II) protein family
S58_RS16595	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
S58_RS16595	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
S58_RS16615	COG0544	peptidyl-prolyl cis-trans isomerase activity
S58_RS16620	COG0740	serine-type endopeptidase activity
S58_RS16625	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
S58_RS16630	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
S58_RS16660	COG2226	methyltransferase
S58_RS16665	COG2195	Cleaves the N-terminal amino acid of tripeptides
S58_RS16695	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
S58_RS16705	COG0649	NAD binding
S58_RS16715	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
S58_RS16725	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
S58_RS16735	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
S58_RS16740	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
S58_RS16750	COG0713	ATP synthesis coupled electron transport
S58_RS16765	COG1007	ATP synthesis coupled electron transport
S58_RS16780	COG0346	lactoylglutathione lyase activity
S58_RS16795	COG1172	Belongs to the binding-protein-dependent transport system permease family
S58_RS16800	COG1129	ABC transporter
S58_RS16830	COG4774	siderophore transport
S58_RS16840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S58_RS16845	COG0442	prolyl-tRNA aminoacylation
S58_RS16855	COG1136	(ABC) transporter
S58_RS16895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S58_RS16910	COG0052	Belongs to the universal ribosomal protein uS2 family
S58_RS16915	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
S58_RS16920	COG0528	UMP kinase activity
S58_RS16925	COG0233	cytoplasmic translational termination
S58_RS16930	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
S58_RS16935	COG0575	Belongs to the CDS family
S58_RS16940	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
S58_RS16945	COG0750	zinc metalloprotease
S58_RS16950	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
S58_RS16955	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
S58_RS16960	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S58_RS16965	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
S58_RS16975	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
S58_RS16985	COG0372	Belongs to the citrate synthase family
S58_RS16990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S58_RS16995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S58_RS17075	COG1475	DNA binding
S58_RS17080	COG5489	Protein of unknown function (DUF736)
S58_RS17180	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
S58_RS17185	COG0303	'Molybdopterin
S58_RS17220	COG1011	Hydrolase
S58_RS17230	COG0793	Belongs to the peptidase S41A family
S58_RS17235	COG5001	Diguanylate cyclase
S58_RS17235	COG3300	MHYT domain
S58_RS17240	COG0315	cyclic pyranopterin monophosphate synthase activity
S58_RS17245	COG0134	indole-3-glycerol-phosphate synthase activity
S58_RS17250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
S58_RS17260	COG0149	triose-phosphate isomerase activity
S58_RS17280	COG0504	CTP synthase activity
S58_RS17285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
S58_RS17290	COG2205	protein histidine kinase activity
S58_RS17295	COG0745	RESPONSE REGULATOR receiver
S58_RS17305	COG2877	3-deoxy-8-phosphooctulonate synthase activity
S58_RS17315	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
S58_RS17330	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
S58_RS17335	COG0148	phosphopyruvate hydratase activity
S58_RS17340	COG1063	alcohol dehydrogenase
S58_RS17355	COG0431	NADPH-dependent FMN reductase
S58_RS17360	COG0235	Class ii aldolase
S58_RS17375	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S58_RS17380	COG0022	dehydrogenase e1 component
S58_RS17380	COG0508	dehydrogenase complex catalyzes the overall conversion of
S58_RS17390	COG0508	dehydrogenase complex catalyzes the overall conversion of
S58_RS17395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S58_RS17410	COG0129	dihydroxy-acid dehydratase activity
S58_RS17415	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
S58_RS17465	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
S58_RS17470	COG0830	nickel cation binding
S58_RS17480	COG0804	urea catabolic process
S58_RS17485	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
S58_RS17490	COG0829	nickel cation binding
S58_RS17505	COG0667	Aldo Keto reductase
S58_RS17550	COG2198	Histidine kinase
S58_RS17550	COG0784	Response regulator, receiver
S58_RS17550	COG5002	protein histidine kinase activity
S58_RS17560	COG0232	Belongs to the dGTPase family. Type 2 subfamily
S58_RS17565	COG0018	arginyl-trna synthetase
S58_RS17575	COG1472	Belongs to the glycosyl hydrolase 3 family
S58_RS17580	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
S58_RS17585	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
S58_RS17590	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S58_RS17595	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S58_RS17600	COG0805	protein transport
S58_RS17605	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
S58_RS17615	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
S58_RS17625	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
S58_RS17640	COG1862	Preprotein translocase
S58_RS17645	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S58_RS17680	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
S58_RS17735	COG0640	Transcriptional regulator
S58_RS17740	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS17760	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S58_RS17765	COG0697	spore germination
S58_RS17770	COG4191	Histidine kinase
S58_RS17770	COG0784	Response regulator, receiver
S58_RS17775	COG4191	Histidine kinase
S58_RS17775	COG0784	Response regulator, receiver
S58_RS17805	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS17815	COG0765	amino acid transport
S58_RS17840	COG1448	Aminotransferase
S58_RS17845	COG0657	acetylesterase activity
S58_RS17860	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
S58_RS17865	COG2197	response regulator
S58_RS17870	COG0784	Response regulator, receiver
S58_RS17885	COG0511	ligase activity, forming carbon-carbon bonds
S58_RS17890	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
S58_RS17905	COG1053	succinate dehydrogenase
S58_RS17925	COG0436	Aminotransferase
S58_RS17930	COG1301	dicarboxylic acid transport
S58_RS17935	COG1530	ribonuclease E activity
S58_RS17935	COG1530	ribonuclease E activity
S58_RS17940	COG0860	N-Acetylmuramoyl-L-alanine amidase
S58_RS17945	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
S58_RS17960	COG2084	Dehydrogenase
S58_RS17965	COG0697	spore germination
S58_RS17970	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
S58_RS17985	COG0840	transmembrane signaling receptor activity
S58_RS18010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S58_RS18015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
S58_RS18020	COG0626	cystathionine gamma-synthase activity
S58_RS18035	COG0739	heme binding
S58_RS18040	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
S58_RS18060	COG2271	Major facilitator Superfamily
S58_RS18065	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S58_RS18070	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
S58_RS18080	COG2945	thiolester hydrolase activity
S58_RS18095	COG0719	Fe-S assembly protein
S58_RS18100	COG0396	ATPase activity
S58_RS18105	COG0719	Fe-S assembly protein
S58_RS18110	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S58_RS18120	COG0316	Belongs to the HesB IscA family
S58_RS18135	COG0513	Belongs to the DEAD box helicase family
S58_RS18145	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS18160	COG0187	DNA topoisomerase II activity
S58_RS18165	COG0586	Pfam SNARE associated Golgi protein
S58_RS18180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
S58_RS18195	COG1175	transmembrane transport
S58_RS18200	COG0395	ABC-type sugar transport system, permease component
S58_RS18205	COG0673	inositol 2-dehydrogenase activity
S58_RS18215	COG1609	Transcriptional regulator
S58_RS18225	COG3243	poly(R)-hydroxyalkanoic acid synthase
S58_RS18235	COG0436	Aminotransferase
S58_RS18245	COG1494	fructose-1,6-bisphosphatase
S58_RS18255	COG0840	transmembrane signaling receptor activity
S58_RS18260	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
S58_RS18305	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S58_RS18325	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
S58_RS18345	COG1012	belongs to the aldehyde dehydrogenase family
S58_RS18350	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
S58_RS18375	COG0156	8-amino-7-oxononanoate synthase activity
S58_RS18415	COG0625	glutathione transferase activity
S58_RS18435	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
S58_RS18440	COG1278	Cold shock
S58_RS18450	COG1136	(ABC) transporter
S58_RS18455	COG0577	efflux transmembrane transporter activity
S58_RS18455	COG1136	(ABC) transporter
S58_RS18480	COG1522	sequence-specific DNA binding
S58_RS18490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S58_RS18505	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
S58_RS18515	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
S58_RS18550	COG2346	COG2346, Truncated hemoglobins
S58_RS18565	COG3800	Transcriptional regulator
S58_RS18565	COG1396	sequence-specific DNA binding
S58_RS18575	COG1280	lysine exporter protein (LysE YggA)
S58_RS18635	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
S58_RS18650	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
S58_RS18690	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
S58_RS18695	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
S58_RS18710	COG4166	transmembrane transport
S58_RS18725	COG0679	Auxin Efflux Carrier
S58_RS18730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S58_RS18735	COG1183	phosphatidylcholine synthase activity
S58_RS18740	COG1253	flavin adenine dinucleotide binding
S58_RS18760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S58_RS18770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S58_RS18775	COG3707	response regulator
S58_RS18780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S58_RS18780	COG1116	anion transmembrane transporter activity
S58_RS18785	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S58_RS18790	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S58_RS18795	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
S58_RS18800	COG1984	allophanate hydrolase subunit 2
S58_RS18805	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
S58_RS18810	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
S58_RS18810	COG0473	3-isopropylmalate dehydrogenase activity
S58_RS18830	COG2515	1-aminocyclopropane-1-carboxylate deaminase
S58_RS18870	COG0395	ABC-type sugar transport system, permease component
S58_RS18875	COG1175	transmembrane transport
S58_RS18930	COG2267	carboxylic ester hydrolase activity
S58_RS18935	COG1686	Belongs to the peptidase S11 family
S58_RS18940	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
S58_RS18955	COG0084	hydrolase, TatD family'
S58_RS18960	COG0321	lipoyl(octanoyl) transferase activity
S58_RS18960	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
S58_RS18970	COG0318	PFAM AMP-dependent synthetase and ligase
S58_RS18975	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
S58_RS18980	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
S58_RS19000	COG1129	ABC transporter
S58_RS19010	COG0559	Belongs to the binding-protein-dependent transport system permease family
S58_RS19015	COG0683	leucine binding
S58_RS19040	COG2723	6-phospho-beta-galactosidase activity
S58_RS19065	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
S58_RS19070	COG3956	TIGRFAM MazG family protein
S58_RS19080	COG2814	Major facilitator Superfamily
S58_RS19090	COG0028	Belongs to the TPP enzyme family
S58_RS19100	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
S58_RS19105	COG1923	regulation of RNA biosynthetic process
S58_RS19110	COG2204	response regulator
S58_RS19115	COG5000	phosphorelay sensor kinase activity
S58_RS19125	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
S58_RS19130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S58_RS19175	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
S58_RS19175	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
S58_RS19180	COG1546	Belongs to the CinA family
S58_RS19180	COG1058	Belongs to the CinA family
S58_RS19190	COG2867	negative regulation of translational initiation
S58_RS19195	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
S58_RS19200	COG2094	Belongs to the DNA glycosylase MPG family
S58_RS19205	COG0525	valine-tRNA ligase activity
S58_RS19220	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
S58_RS19250	COG2204	response regulator
S58_RS19270	COG0723	plastoquinol--plastocyanin reductase activity
S58_RS19290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S58_RS19315	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
S58_RS19325	COG1126	abc transporter atp-binding protein
S58_RS19330	COG0765	amino acid transport
S58_RS19335	COG4597	amino acid ABC transporter
S58_RS19340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S58_RS19345	COG0626	cystathionine gamma-synthase activity
S58_RS19360	COG0463	Glycosyl transferase, family 2
S58_RS19365	COG0671	phosphoesterase, PA-phosphatase related
S58_RS19375	COG4953	penicillin-binding protein 1C
S58_RS19380	COG2373	Large extracellular alpha-helical protein
S58_RS19420	COG2814	Major facilitator Superfamily
S58_RS19440	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS19460	COG0243	molybdopterin cofactor binding
S58_RS19490	COG1472	Belongs to the glycosyl hydrolase 3 family
S58_RS19500	COG0745	RESPONSE REGULATOR receiver
S58_RS19505	COG2205	protein histidine kinase activity
S58_RS19515	COG0601	transmembrane transport
S58_RS19520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S58_RS19525	COG4172	Belongs to the ABC transporter superfamily
S58_RS19530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S58_RS19540	COG0543	2 iron, 2 sulfur cluster binding
S58_RS19540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S58_RS19550	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
S58_RS19555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S58_RS19575	COG0457	Tetratricopeptide repeat
S58_RS19580	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
S58_RS19600	COG0697	spore germination
S58_RS19630	COG0343	queuine tRNA-ribosyltransferase activity
S58_RS19640	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
S58_RS19645	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
S58_RS19660	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
S58_RS19670	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S58_RS19685	COG0629	single-stranded DNA binding
S58_RS19715	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
S58_RS19730	COG0546	phosphoglycolate phosphatase activity
S58_RS19745	COG3318	Belongs to the UPF0149 family
S58_RS19745	COG3012	SEC-C Motif Domain Protein
S58_RS19760	COG2124	cytochrome p450
S58_RS19765	COG3750	Belongs to the UPF0335 family
S58_RS19770	COG2824	Alkylphosphonate utilization operon protein PhnA
S58_RS19780	COG2514	catechol 2,3-dioxygenase activity
S58_RS19820	COG1250	3-hydroxyacyl-CoA dehydrogenase
S58_RS19825	COG0583	DNA-binding transcription factor activity
S58_RS19910	COG0546	phosphoglycolate phosphatase activity
S58_RS19950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S58_RS19955	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
S58_RS19960	COG0840	transmembrane signaling receptor activity
S58_RS19990	COG1960	acyl-CoA dehydrogenase activity
S58_RS20005	COG1172	Belongs to the binding-protein-dependent transport system permease family
S58_RS20020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S58_RS20045	COG0784	Response regulator, receiver
S58_RS20045	COG4191	Histidine kinase
S58_RS20050	COG0488	(ABC) transporter
S58_RS20060	COG0174	glutamine synthetase
S58_RS20070	COG2365	Tyrosine phosphatase family
S58_RS20085	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS20110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S58_RS20150	COG3045	CreA protein
S58_RS20160	COG0386	Belongs to the glutathione peroxidase family
S58_RS20165	COG0726	polysaccharide deacetylase
S58_RS20180	COG0281	malic enzyme
S58_RS20180	COG0280	phosphate acetyltransferase
S58_RS20205	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
S58_RS20215	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
S58_RS20220	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
S58_RS20225	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
S58_RS20250	COG0583	DNA-binding transcription factor activity
S58_RS20260	COG1278	Cold shock
S58_RS20265	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
S58_RS20270	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
S58_RS20285	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
S58_RS20305	COG1618	nucleotide phosphatase activity, acting on free nucleotides
S58_RS20305	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
S58_RS20310	COG0528	UMP kinase activity
S58_RS20315	COG0528	UMP kinase activity
S58_RS20320	COG1012	belongs to the aldehyde dehydrogenase family
S58_RS20330	COG0861	Integral membrane protein TerC family
S58_RS20335	COG0105	UTP biosynthetic process
S58_RS20350	COG0488	(ABC) transporter
S58_RS20365	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
S58_RS20370	COG0795	lipopolysaccharide-transporting ATPase activity
S58_RS20380	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
S58_RS20390	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
S58_RS20395	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
S58_RS20410	COG0194	GDP metabolic process
S58_RS20415	COG1561	YicC-like family, N-terminal region
S58_RS20420	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S58_RS20425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S58_RS20430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S58_RS20440	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
S58_RS20445	COG0360	Binds together with S18 to 16S ribosomal RNA
S58_RS20450	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
S58_RS20460	COG0359	binds to the 23S rRNA
S58_RS20475	COG0305	Participates in initiation and elongation during chromosome replication
S58_RS20480	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
S58_RS20525	COG2207	Transcriptional regulator
S58_RS20545	COG1286	toxin biosynthetic process
S58_RS20550	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
S58_RS20555	COG0300	oxidoreductase activity
S58_RS20565	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
S58_RS20610	COG2815	serine threonine protein kinase
S58_RS20610	COG0515	serine threonine protein kinase
S58_RS20615	COG2223	nitrite transmembrane transporter activity
S58_RS20620	COG1160	GTP binding
S58_RS20635	COG0318	PFAM AMP-dependent synthetase and ligase
S58_RS20640	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
S58_RS20660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S58_RS20665	COG2197	response regulator
S58_RS20680	COG0306	phosphate transporter
S58_RS20685	COG1392	Phosphate transport regulator
S58_RS20690	COG4214	carbohydrate transport
S58_RS20745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S58_RS20750	COG1393	Belongs to the ArsC family
S58_RS20760	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
S58_RS20785	COG0625	glutathione transferase activity
S58_RS20845	COG1349	DNA-binding transcription factor activity
S58_RS20855	COG3842	ATPase activity
S58_RS20865	COG4303	Ethanolamine ammonia lyase large subunit
S58_RS20870	COG4302	ethanolamine ammonia-lyase activity
S58_RS20885	COG1172	Belongs to the binding-protein-dependent transport system permease family
S58_RS21045	COG0446	pyridine nucleotide-disulphide oxidoreductase
S58_RS21050	COG0640	Transcriptional regulator
S58_RS21080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S58_RS21085	COG0601	transmembrane transport
S58_RS21090	COG0747	negative chemotaxis
S58_RS21095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S58_RS21100	COG2188	Transcriptional regulator
S58_RS21105	COG2376	Dihydroxyacetone kinase
S58_RS21115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
S58_RS21120	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
S58_RS21130	COG1461	Dihydroxyacetone kinase
S58_RS21135	COG3842	ATPase activity
S58_RS21140	COG3842	ATPase activity
S58_RS21150	COG0395	ABC-type sugar transport system, permease component
S58_RS21155	COG1175	transmembrane transport
S58_RS21170	COG1595	DNA-templated transcription, initiation
S58_RS21180	COG2195	Cleaves the N-terminal amino acid of tripeptides
S58_RS21200	COG4154	Belongs to the RbsD FucU family
S58_RS21220	COG0590	tRNA wobble adenosine to inosine editing
S58_RS21235	COG3665	Urea carboxylase-associated protein
S58_RS21240	COG3665	Urea carboxylase-associated protein
S58_RS21245	COG0251	oxidation-reduction process
S58_RS21255	COG0765	amino acid transport
S58_RS21260	COG0765	amino acid transport
S58_RS21265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S58_RS21280	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S58_RS21325	COG2188	Transcriptional regulator
S58_RS21345	COG0697	spore germination
S58_RS21360	COG0745	RESPONSE REGULATOR receiver
S58_RS21410	COG2771	luxR family
S58_RS21415	COG3916	Acyl-homoserine-lactone synthase
S58_RS21445	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
S58_RS21495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S58_RS21505	COG2391	methyltransferase activity
S58_RS21515	COG2391	methyltransferase activity
S58_RS21540	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
S58_RS21545	COG0737	Belongs to the 5'-nucleotidase family
S58_RS21580	COG0785	Cytochrome C biogenesis protein
S58_RS21590	COG0640	Transcriptional regulator
S58_RS21625	COG0444	Belongs to the ABC transporter superfamily
S58_RS21630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S58_RS21635	COG0601	transmembrane transport
S58_RS21645	COG0523	cobalamin synthesis protein
S58_RS21655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S58_RS21670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S58_RS21695	COG0625	glutathione transferase activity
S58_RS21710	COG0583	DNA-binding transcription factor activity
S58_RS21730	COG0583	DNA-binding transcription factor activity
S58_RS21735	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS21755	COG3220	belongs to the UPF0276 family
S58_RS21765	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
S58_RS21785	COG0519	Catalyzes the synthesis of GMP from XMP
S58_RS21785	COG0518	GMP synthase (glutamine-hydrolyzing) activity
S58_RS21800	COG2130	NADP-dependent
S58_RS21820	COG1215	transferase activity, transferring glycosyl groups
S58_RS21860	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
S58_RS21865	COG0248	Ppx GppA phosphatase
S58_RS21880	COG1671	Belongs to the UPF0178 family
S58_RS21885	COG0488	(ABC) transporter
S58_RS21900	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS21910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S58_RS21925	COG1960	acyl-CoA dehydrogenase activity
S58_RS21940	COG1024	Enoyl-CoA hydratase
S58_RS21945	COG2271	Major facilitator Superfamily
S58_RS21950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S58_RS21960	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
S58_RS21960	COG2066	Belongs to the glutaminase family
S58_RS21985	COG1804	L-carnitine dehydratase bile acid-inducible protein F
S58_RS21995	COG4651	solute:proton antiporter activity
S58_RS21995	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
S58_RS22010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S58_RS22015	COG0395	ABC-type sugar transport system, permease component
S58_RS22030	COG3842	ATPase activity
S58_RS22035	COG1609	Transcriptional regulator
S58_RS22040	COG0129	dihydroxy-acid dehydratase activity
S58_RS22045	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS22050	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS22070	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS22080	COG0203	ribosomal protein L17
S58_RS22085	COG0202	RNA polymerase activity
S58_RS22090	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
S58_RS22095	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
S58_RS22100	COG0563	adenylate kinase activity
S58_RS22105	COG0201	protein transport
S58_RS22110	COG0200	Binds to the 23S rRNA
S58_RS22115	COG1841	ribosomal large subunit assembly
S58_RS22120	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
S58_RS22125	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
S58_RS22130	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
S58_RS22135	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
S58_RS22140	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S58_RS22145	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
S58_RS22150	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
S58_RS22155	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
S58_RS22160	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
S58_RS22165	COG0255	Belongs to the universal ribosomal protein uL29 family
S58_RS22170	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
S58_RS22175	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
S58_RS22180	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
S58_RS22185	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
S58_RS22190	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
S58_RS22195	COG0089	rRNA binding
S58_RS22200	COG0088	Forms part of the polypeptide exit tunnel
S58_RS22205	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
S58_RS22210	COG0051	transcription antitermination factor activity, RNA binding
S58_RS22215	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
S58_RS22220	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
S58_RS22225	COG0049	tRNA binding
S58_RS22230	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
S58_RS22240	COG1132	(ABC) transporter
S58_RS22245	COG1231	oxidoreductase activity
S58_RS22250	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
S58_RS22255	COG0085	RNA polymerase activity
S58_RS22260	COG0222	ribosome binding
S58_RS22265	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
S58_RS22290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S58_RS22295	COG0081	regulation of translation
S58_RS22300	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
S58_RS22310	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
S58_RS22340	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS22365	COG1960	acyl-CoA dehydrogenase activity
S58_RS22410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S58_RS22415	COG4608	Belongs to the ABC transporter superfamily
S58_RS22420	COG0444	Belongs to the ABC transporter superfamily
S58_RS22425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S58_RS22430	COG0601	transmembrane transport
S58_RS22435	COG0747	negative chemotaxis
S58_RS22465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S58_RS22475	COG1960	acyl-CoA dehydrogenase activity
S58_RS22480	COG1116	anion transmembrane transporter activity
S58_RS22500	COG1464	Belongs to the NlpA lipoprotein family
S58_RS22530	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
S58_RS22530	COG2755	lipolytic protein G-D-S-L family
S58_RS22535	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
S58_RS22570	COG1538	Outer membrane efflux protein
S58_RS22580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S58_RS22675	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
S58_RS22680	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S58_RS22705	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
S58_RS22710	COG0302	gtp cyclohydrolase
S58_RS22725	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
S58_RS22740	COG0531	amino acid
S58_RS22755	COG2814	Major facilitator Superfamily
S58_RS22765	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
S58_RS22780	COG5001	Diguanylate cyclase
S58_RS22795	COG1752	Esterase of the alpha-beta hydrolase superfamily
S58_RS22815	COG4249	Peptidase C14 caspase catalytic subunit p20
S58_RS22815	COG2319	Wd-40 repeat
S58_RS22825	COG3591	Belongs to the peptidase S1B family
S58_RS22825	COG1864	DNA RNA non-specific endonuclease
S58_RS22830	COG1234	tRNA 3'-trailer cleavage
S58_RS22855	COG0412	Dienelactone hydrolase
S58_RS22920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S58_RS22945	COG0640	Transcriptional regulator
S58_RS22960	COG0747	negative chemotaxis
S58_RS22965	COG0747	negative chemotaxis
S58_RS22975	COG0601	transmembrane transport
S58_RS22980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S58_RS22995	COG1473	amidohydrolase
S58_RS23000	COG0154	amidase activity
S58_RS23005	COG1024	Enoyl-CoA hydratase
S58_RS23025	COG0625	glutathione transferase activity
S58_RS23030	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S58_RS23055	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
S58_RS23060	COG1546	Belongs to the CinA family
S58_RS23060	COG1058	Belongs to the CinA family
S58_RS23065	COG2308	Evidence 4 Homologs of previously reported genes of
S58_RS23095	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S58_RS23110	COG5425	PFAM Usg family protein
S58_RS23115	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
S58_RS23120	COG0459	protein refolding
S58_RS23125	COG0681	Belongs to the peptidase S26 family
S58_RS23135	COG1690	Belongs to the RtcB family
S58_RS23215	COG0842	Transport permease protein
S58_RS23220	COG1131	(ABC) transporter
S58_RS23230	COG1309	transcriptional regulator
S58_RS23250	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
S58_RS23255	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
S58_RS23255	COG3608	succinylglutamate desuccinylase aspartoacylase
S58_RS23290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
S58_RS23330	COG0784	Response regulator, receiver
S58_RS23330	COG4191	Histidine kinase
S58_RS23355	COG3257	ureidoglycine aminohydrolase activity
S58_RS23360	COG1301	dicarboxylic acid transport
S58_RS23400	COG2197	response regulator
S58_RS23405	COG1309	transcriptional regulator
S58_RS23415	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
S58_RS23465	COG1473	amidohydrolase
S58_RS23480	COG3920	Histidine kinase
S58_RS23500	COG1181	Belongs to the D-alanine--D-alanine ligase family
S58_RS23565	COG0640	Transcriptional regulator
S58_RS23570	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
S58_RS23590	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
S58_RS23610	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
S58_RS23620	COG1262	PFAM Formylglycine-generating sulfatase enzyme
S58_RS23625	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
S58_RS23655	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S58_RS23685	COG0596	Alpha beta hydrolase
S58_RS23690	COG0583	DNA-binding transcription factor activity
S58_RS23695	COG1301	dicarboxylic acid transport
S58_RS23705	COG0047	phosphoribosylformylglycinamidine synthase activity
S58_RS23715	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S58_RS23720	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
S58_RS23730	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
S58_RS23735	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S58_RS23735	COG1116	anion transmembrane transporter activity
S58_RS23740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S58_RS23745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S58_RS23800	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
S58_RS23805	COG0538	isocitrate dehydrogenase activity
S58_RS23820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S58_RS23825	COG1126	abc transporter atp-binding protein
S58_RS23830	COG0765	amino acid transport
S58_RS23840	COG1396	sequence-specific DNA binding
S58_RS23840	COG3800	Transcriptional regulator
S58_RS23850	COG2372	response to copper ion
S58_RS23855	COG0129	dihydroxy-acid dehydratase activity
S58_RS23880	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
S58_RS23885	COG2205	protein histidine kinase activity
S58_RS23890	COG0745	RESPONSE REGULATOR receiver
S58_RS23915	COG3088	subunit of a heme lyase
S58_RS23920	COG1138	Cytochrome C-type biogenesis protein
S58_RS23925	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
S58_RS23930	COG4235	cytochrome complex assembly
S58_RS23955	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
S58_RS23975	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
S58_RS23980	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
S58_RS23985	COG1360	Flagellar Motor Protein
S58_RS23995	COG0477	Major facilitator Superfamily
S58_RS24000	COG2983	Belongs to the UPF0260 family
S58_RS24020	COG2954	triphosphatase activity
S58_RS24035	COG0583	DNA-binding transcription factor activity
S58_RS24065	COG2205	protein histidine kinase activity
S58_RS24075	COG2166	iron-sulfur cluster assembly
S58_RS24080	COG4957	zinc ion binding
S58_RS24105	COG0071	Belongs to the small heat shock protein (HSP20) family
S58_RS24115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S58_RS24135	COG0433	COG0433 Predicted ATPase
S58_RS24145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
S58_RS24155	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
S58_RS24190	COG1703	isobutyryl-CoA mutase activity
S58_RS24215	COG1309	transcriptional regulator
S58_RS24225	COG1404	Belongs to the peptidase S8 family
S58_RS24265	COG1024	Enoyl-CoA hydratase
S58_RS24290	COG0628	permease
S58_RS24310	COG0683	leucine binding
S58_RS24345	COG0587	DNA-directed DNA polymerase activity
S58_RS24365	COG1573	uracil-dna glycosylase
S58_RS24370	COG1473	amidohydrolase
S58_RS24395	COG1595	DNA-templated transcription, initiation
S58_RS24420	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
S58_RS24430	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
S58_RS24435	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
S58_RS24440	COG1562	ergosterol biosynthetic process
S58_RS24445	COG1562	ergosterol biosynthetic process
S58_RS24475	COG0302	gtp cyclohydrolase
S58_RS24480	COG1595	DNA-templated transcription, initiation
S58_RS24490	COG1595	DNA-templated transcription, initiation
S58_RS24495	COG3046	protein related to deoxyribodipyrimidine photolyase
S58_RS24540	COG2308	Evidence 4 Homologs of previously reported genes of
S58_RS24540	COG2307	Protein conserved in bacteria
S58_RS24555	COG2721	sulfolactate sulfo-lyase activity
S58_RS24565	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
S58_RS24570	COG1846	Transcriptional regulator
S58_RS24575	COG3971	2-oxopent-4-enoate hydratase activity
S58_RS24585	COG1012	belongs to the aldehyde dehydrogenase family
S58_RS24590	COG0179	Fumarylacetoacetate (FAA) hydrolase
S58_RS24595	COG0028	Belongs to the TPP enzyme family
S58_RS24605	COG3145	DNA-N1-methyladenine dioxygenase activity
S58_RS24615	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
S58_RS24640	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS24650	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
S58_RS24660	COG1024	Enoyl-CoA hydratase
S58_RS24675	COG1960	acyl-CoA dehydrogenase activity
S58_RS24680	COG1024	Enoyl-CoA hydratase
S58_RS24695	COG1024	Enoyl-CoA hydratase
S58_RS24700	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS24715	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S58_RS24730	COG0625	glutathione transferase activity
S58_RS24750	COG1234	tRNA 3'-trailer cleavage
S58_RS24755	COG0840	transmembrane signaling receptor activity
S58_RS24760	COG0840	transmembrane signaling receptor activity
S58_RS24765	COG0840	transmembrane signaling receptor activity
S58_RS24780	COG0840	transmembrane signaling receptor activity
S58_RS24785	COG0840	transmembrane signaling receptor activity
S58_RS24790	COG3395	kinase activity
S58_RS24795	COG3622	Belongs to the hyi family
S58_RS24800	COG2084	Dehydrogenase
S58_RS24805	COG0235	Class ii aldolase
S58_RS24815	COG3842	ATPase activity
S58_RS24830	COG3833	ABC-type maltose transport systems, permease component
S58_RS24865	COG4336	lyase activity
S58_RS24870	COG0583	DNA-binding transcription factor activity
S58_RS24880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S58_RS24890	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS24900	COG0477	Major facilitator Superfamily
S58_RS24905	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
S58_RS24925	COG2050	protein possibly involved in aromatic compounds catabolism
S58_RS24935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S58_RS24940	COG2151	metal-sulfur cluster biosynthetic enzyme
S58_RS24945	COG3396	Phenylacetate-CoA oxygenase
S58_RS24950	COG3460	Phenylacetate-CoA oxygenase
S58_RS24955	COG3396	Phenylacetate-CoA oxygenase
S58_RS24960	COG3327	negative regulation of DNA-templated transcription, initiation
S58_RS24980	COG2267	carboxylic ester hydrolase activity
S58_RS24990	COG0747	negative chemotaxis
S58_RS24995	COG0601	transmembrane transport
S58_RS25000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S58_RS25005	COG0444	Belongs to the ABC transporter superfamily
S58_RS25010	COG4608	Belongs to the ABC transporter superfamily
S58_RS25025	COG0747	negative chemotaxis
S58_RS25030	COG0601	transmembrane transport
S58_RS25035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S58_RS25040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S58_RS25045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S58_RS25055	COG2124	cytochrome p450
S58_RS25080	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S58_RS25085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S58_RS25090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S58_RS25100	COG1024	Enoyl-CoA hydratase
S58_RS25120	COG0129	dihydroxy-acid dehydratase activity
S58_RS25125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S58_RS25140	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
S58_RS25145	COG1522	sequence-specific DNA binding
S58_RS25155	COG0543	2 iron, 2 sulfur cluster binding
S58_RS25155	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S58_RS25165	COG0697	spore germination
S58_RS25170	COG0656	L-ascorbic acid biosynthetic process
S58_RS25175	COG0243	molybdopterin cofactor binding
S58_RS25180	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S58_RS25190	COG1116	anion transmembrane transporter activity
S58_RS25195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S58_RS25200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S58_RS25205	COG2116	formate transmembrane transporter activity
S58_RS25215	COG3485	protocatechuate 3,4-dioxygenase
S58_RS25225	COG3920	Histidine kinase
S58_RS25225	COG2202	Pas domain
S58_RS25230	COG0785	Cytochrome C biogenesis protein
S58_RS25245	COG1396	sequence-specific DNA binding
S58_RS25250	COG1024	Enoyl-CoA hydratase
S58_RS25255	COG0473	3-isopropylmalate dehydrogenase activity
S58_RS25270	COG0297	glycogen (starch) synthase activity
S58_RS25290	COG2217	Heavy metal translocating P-type atpase
S58_RS25305	COG2010	Cytochrome c
S58_RS25320	COG3278	Belongs to the heme-copper respiratory oxidase family
S58_RS25325	COG4109	DRTGG domain
S58_RS25335	COG4191	Histidine kinase
S58_RS25340	COG4566	intracellular signal transduction
S58_RS25345	COG0745	RESPONSE REGULATOR receiver
S58_RS25350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S58_RS25370	COG1132	(ABC) transporter
S58_RS25375	COG0438	transferase activity, transferring glycosyl groups
S58_RS25380	COG2015	COG2015, Alkyl sulfatase and related hydrolases
S58_RS25385	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S58_RS25390	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
S58_RS25395	COG0156	8-amino-7-oxononanoate synthase activity
S58_RS25400	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
S58_RS25405	COG1802	Transcriptional regulator
S58_RS25410	COG0473	3-isopropylmalate dehydrogenase activity
S58_RS25415	COG2814	Major facilitator Superfamily
S58_RS25430	COG0446	pyridine nucleotide-disulphide oxidoreductase
S58_RS25455	COG0583	DNA-binding transcription factor activity
S58_RS25470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S58_RS25480	COG1335	isochorismatase
S58_RS25485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S58_RS25510	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
S58_RS25515	COG1845	cytochrome c oxidase, subunit III
S58_RS25535	COG0183	Belongs to the thiolase family
S58_RS25545	COG3618	amidohydrolase
S58_RS25550	COG1301	dicarboxylic acid transport
S58_RS25565	COG1309	transcriptional regulator
S58_RS25575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S58_RS25580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S58_RS25585	COG1695	Transcriptional regulator
S58_RS25605	COG0583	DNA-binding transcription factor activity
S58_RS25675	COG1172	Belongs to the binding-protein-dependent transport system permease family
S58_RS25680	COG1129	ABC transporter
S58_RS25685	COG2115	Belongs to the xylose isomerase family
S58_RS25690	COG1070	Carbohydrate kinase
S58_RS25710	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
S58_RS25725	COG2124	cytochrome p450
S58_RS25730	COG1902	pentaerythritol trinitrate reductase activity
S58_RS25740	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
S58_RS25745	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
S58_RS25790	COG2159	amidohydrolase
S58_RS25800	COG0583	DNA-binding transcription factor activity
S58_RS25805	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
S58_RS25825	COG0251	oxidation-reduction process
S58_RS25860	COG1024	Enoyl-CoA hydratase
S58_RS25865	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS25880	COG0318	PFAM AMP-dependent synthetase and ligase
S58_RS25890	COG1250	3-hydroxyacyl-CoA dehydrogenase
S58_RS25905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S58_RS25910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S58_RS25920	COG0129	dihydroxy-acid dehydratase activity
S58_RS25925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S58_RS25930	COG0251	oxidation-reduction process
S58_RS25940	COG2204	response regulator
S58_RS25950	COG1252	NADH dehydrogenase
S58_RS25955	COG0281	malic enzyme
S58_RS25955	COG0280	phosphate acetyltransferase
S58_RS25960	COG1301	dicarboxylic acid transport
S58_RS25965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S58_RS25970	COG0508	dehydrogenase complex catalyzes the overall conversion of
S58_RS26000	COG0657	acetylesterase activity
S58_RS26025	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
S58_RS26035	COG4774	siderophore transport
S58_RS26085	COG1172	Belongs to the binding-protein-dependent transport system permease family
S58_RS26100	COG1349	DNA-binding transcription factor activity
S58_RS26105	COG3347	Dehydrogenase
S58_RS26105	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS26110	COG4952	isomerase
S58_RS26115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S58_RS26120	COG1522	sequence-specific DNA binding
S58_RS26135	COG0601	transmembrane transport
S58_RS26165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S58_RS26170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S58_RS26195	COG1960	acyl-CoA dehydrogenase activity
S58_RS26230	COG3546	catalase activity
S58_RS26255	COG1024	Enoyl-CoA hydratase
S58_RS26265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S58_RS26270	COG1525	nuclease
S58_RS26270	COG4085	toxin activity
S58_RS26270	COG0737	Belongs to the 5'-nucleotidase family
S58_RS26275	COG0123	including yeast histone deacetylase and acetoin utilization protein
S58_RS26280	COG1722	exodeoxyribonuclease VII activity
S58_RS26290	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
S58_RS26300	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
S58_RS26305	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S58_RS26310	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
S58_RS26320	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
S58_RS26330	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
S58_RS26340	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
S58_RS26355	COG0484	heat shock protein binding
S58_RS26365	COG0259	pyridoxamine-phosphate oxidase activity
S58_RS26370	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS26400	COG2814	Major facilitator Superfamily
S58_RS26410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S58_RS26415	COG1960	acyl-CoA dehydrogenase activity
S58_RS26420	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S58_RS26420	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S58_RS26425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S58_RS26430	COG3964	amidohydrolase
S58_RS26445	COG0656	L-ascorbic acid biosynthetic process
S58_RS26460	COG1172	Belongs to the binding-protein-dependent transport system permease family
S58_RS26465	COG1129	ABC transporter
S58_RS26470	COG1879	ABC-type sugar transport system periplasmic component
S58_RS26475	COG1984	allophanate hydrolase subunit 2
S58_RS26485	COG0439	Biotin carboxylase
S58_RS26500	COG0583	DNA-binding transcription factor activity
S58_RS26510	COG1846	Transcriptional regulator
S58_RS26550	COG2080	2 iron, 2 sulfur cluster binding
S58_RS26555	COG1529	Aldehyde oxidase and xanthine dehydrogenase
S58_RS26555	COG2010	Cytochrome c
S58_RS26565	COG1176	ABC-type spermidine putrescine transport system, permease component I
S58_RS26570	COG1177	transmembrane transport
S58_RS26575	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
S58_RS26580	COG3842	ATPase activity
S58_RS26600	COG1335	isochorismatase
S58_RS26620	COG1012	belongs to the aldehyde dehydrogenase family
S58_RS26630	COG1280	lysine exporter protein (LysE YggA)
S58_RS26635	COG1280	lysine exporter protein (LysE YggA)
S58_RS26665	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
S58_RS26685	COG0318	PFAM AMP-dependent synthetase and ligase
S58_RS26700	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
S58_RS26705	COG1295	ribonuclease BN
S58_RS26780	COG0009	L-threonylcarbamoyladenylate synthase
S58_RS26785	COG0277	FAD linked oxidase domain protein
S58_RS26790	COG0456	acetyltransferase
S58_RS26795	COG0494	nUDIX hydrolase
S58_RS26800	COG2135	peptidase activity
S58_RS26830	COG2207	Transcriptional regulator
S58_RS26845	COG0517	IMP dehydrogenase activity
S58_RS26850	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S58_RS26860	COG0519	Catalyzes the synthesis of GMP from XMP
S58_RS26865	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
S58_RS26890	COG0840	transmembrane signaling receptor activity
S58_RS26910	COG0604	alcohol dehydrogenase
S58_RS26920	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
S58_RS26940	COG0574	Belongs to the PEP-utilizing enzyme family
S58_RS26940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
S58_RS26950	COG0751	glycine-tRNA ligase activity
S58_RS26955	COG0752	glycyl-tRNA synthetase alpha subunit
S58_RS26980	COG0142	geranyltranstransferase activity
S58_RS26985	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
S58_RS27000	COG1573	uracil-dna glycosylase
S58_RS27010	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
S58_RS27025	COG1032	radical SAM domain protein
S58_RS27045	COG1696	Membrane protein involved in D-alanine export
S58_RS27060	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
S58_RS27070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
S58_RS27070	COG0574	Belongs to the PEP-utilizing enzyme family
S58_RS27080	COG1846	Transcriptional regulator
S58_RS27080	COG0456	acetyltransferase
S58_RS27090	COG0521	Mo-molybdopterin cofactor biosynthetic process
S58_RS27095	COG2321	neutral zinc metallopeptidase
S58_RS27100	COG2189	Belongs to the N(4) N(6)-methyltransferase family
S58_RS27110	COG4251	negative regulation of phosphorylation
S58_RS27140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S58_RS27145	COG3706	GGDEF domain
S58_RS27155	COG0537	adenosine 5'-monophosphoramidase activity
S58_RS27165	COG2070	2-Nitropropane dioxygenase
S58_RS27175	COG1194	a g-specific adenine glycosylase
S58_RS27190	COG1196	nuclear chromosome segregation
S58_RS27205	COG1704	LemA family
S58_RS27210	COG0501	Belongs to the peptidase M48B family
S58_RS27225	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S58_RS27235	COG1309	transcriptional regulator
S58_RS27275	COG1742	UPF0060 membrane protein
S58_RS27280	COG2857	Cytochrome c1
S58_RS27280	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S58_RS27285	COG0723	plastoquinol--plastocyanin reductase activity
S58_RS27290	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
S58_RS27295	COG0602	queuosine metabolic process
S58_RS27305	COG0408	coproporphyrinogen oxidase activity
S58_RS27315	COG2186	Transcriptional regulator
S58_RS27320	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
S58_RS27325	COG1301	dicarboxylic acid transport
S58_RS27340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S58_RS27375	COG0617	tRNA 3'-terminal CCA addition
S58_RS27395	COG0714	Associated with various cellular activities
S58_RS27425	COG4771	TonB-dependent receptor
S58_RS27435	COG4303	Ethanolamine ammonia lyase large subunit
S58_RS27440	COG4302	ethanolamine ammonia-lyase activity
S58_RS27445	COG0531	amino acid
S58_RS27455	COG1473	amidohydrolase
S58_RS27495	COG0583	DNA-binding transcription factor activity
S58_RS27500	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
S58_RS27505	COG2943	transferase activity, transferring hexosyl groups
S58_RS27570	COG1172	Belongs to the binding-protein-dependent transport system permease family
S58_RS27580	COG1129	ABC transporter
S58_RS27585	COG1879	ABC-type sugar transport system periplasmic component
S58_RS27590	COG1902	pentaerythritol trinitrate reductase activity
S58_RS27610	COG2197	response regulator
S58_RS27640	COG0848	biopolymer transport protein
S58_RS27670	COG0395	ABC-type sugar transport system, permease component
S58_RS27680	COG3842	ATPase activity
S58_RS27685	COG3842	ATPase activity
S58_RS27695	COG1349	DNA-binding transcription factor activity
S58_RS27710	COG1607	acyl-coa hydrolase
S58_RS27725	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S58_RS27745	COG3214	Protein conserved in bacteria
S58_RS27755	COG2885	chlorophyll binding
S58_RS27755	COG3047	cAMP biosynthetic process
S58_RS27785	COG0523	cobalamin synthesis protein
S58_RS27795	COG3237	CsbD-like
S58_RS27805	COG0405	Gamma-glutamyltransferase
S58_RS27810	COG1054	Belongs to the UPF0176 family
S58_RS27815	COG2900	Belongs to the SlyX family
S58_RS27820	COG2203	Gaf domain
S58_RS27820	COG5001	Diguanylate cyclase
S58_RS27820	COG3706	GGDEF domain
S58_RS27820	COG4251	negative regulation of phosphorylation
S58_RS27830	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
S58_RS27835	COG0181	hydroxymethylbilane synthase activity
S58_RS27845	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
S58_RS27850	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S58_RS27890	COG2226	methyltransferase
S58_RS27905	COG3920	Histidine kinase
S58_RS27905	COG2202	Pas domain
S58_RS27915	COG0583	DNA-binding transcription factor activity
S58_RS27945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S58_RS28000	COG4214	carbohydrate transport
S58_RS28010	COG4213	ABC transporter substrate-binding protein
S58_RS28015	COG3386	PFAM SMP-30 Gluconolaconase
S58_RS28045	COG1172	Belongs to the binding-protein-dependent transport system permease family
S58_RS28050	COG1172	Belongs to the binding-protein-dependent transport system permease family
S58_RS28055	COG1129	ABC transporter
S58_RS28060	COG1879	ABC-type sugar transport system periplasmic component
S58_RS28065	COG0800	Aldolase
S58_RS28070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S58_RS28075	COG1063	alcohol dehydrogenase
S58_RS28080	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS28085	COG4948	Mandelate Racemase Muconate Lactonizing
S58_RS28095	COG2271	Major facilitator Superfamily
S58_RS28100	COG1312	Catalyzes the dehydration of D-mannonate
S58_RS28115	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
S58_RS28120	COG1063	alcohol dehydrogenase
S58_RS28125	COG0246	Mannitol dehydrogenase
S58_RS28135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S58_RS28140	COG0601	transmembrane transport
S58_RS28145	COG0747	negative chemotaxis
S58_RS28150	COG2072	flavoprotein involved in K transport
S58_RS28155	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS28160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S58_RS28165	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S58_RS28195	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
S58_RS28200	COG0402	S-adenosylhomocysteine deaminase activity
S58_RS28205	COG0747	negative chemotaxis
S58_RS28210	COG0726	polysaccharide deacetylase
S58_RS28215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S58_RS28225	COG0765	amino acid transport
S58_RS28230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S58_RS28260	COG0714	Associated with various cellular activities
S58_RS28265	COG3256	nitric oxide reductase
S58_RS28280	COG1845	cytochrome c oxidase, subunit III
S58_RS28295	COG1473	amidohydrolase
S58_RS28300	COG0154	amidase activity
S58_RS28315	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
S58_RS28325	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
S58_RS28325	COG1618	nucleotide phosphatase activity, acting on free nucleotides
S58_RS28335	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
S58_RS28340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S58_RS28345	COG2072	flavoprotein involved in K transport
S58_RS28350	COG0800	Aldolase
S58_RS28355	COG3734	2-keto-3-deoxy-galactonokinase
S58_RS28360	COG1349	DNA-binding transcription factor activity
S58_RS28365	COG2223	nitrite transmembrane transporter activity
S58_RS28370	COG2155	Conserved Protein
S58_RS28390	COG3845	ABC transporter
S58_RS28395	COG4603	Belongs to the binding-protein-dependent transport system permease family
S58_RS28400	COG1079	Belongs to the binding-protein-dependent transport system permease family
S58_RS28410	COG0747	negative chemotaxis
S58_RS28415	COG0601	transmembrane transport
S58_RS28420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S58_RS28425	COG0444	Belongs to the ABC transporter superfamily
S58_RS28430	COG4608	Belongs to the ABC transporter superfamily
S58_RS28445	COG1529	Aldehyde oxidase and xanthine dehydrogenase
S58_RS28445	COG2080	2 iron, 2 sulfur cluster binding
S58_RS28450	COG2233	PERMEase
S58_RS28475	COG1309	transcriptional regulator
S58_RS28490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S58_RS28505	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
S58_RS28525	COG1845	cytochrome c oxidase, subunit III
S58_RS28530	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S58_RS28535	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
S58_RS28540	COG0477	Major facilitator Superfamily
S58_RS28590	COG2116	formate transmembrane transporter activity
S58_RS28600	COG2204	response regulator
S58_RS28605	COG0309	Hydrogenase expression formation protein (HypE)
S58_RS28610	COG0409	Hydrogenase expression formation protein
S58_RS28625	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
S58_RS28630	COG0375	protein maturation
S58_RS28635	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
S58_RS28640	COG1773	rubredoxin
S58_RS28645	COG1773	rubredoxin
S58_RS28650	COG1773	rubredoxin
S58_RS28655	COG3118	belongs to the thioredoxin family
S58_RS28660	COG0298	carbon dioxide binding
S58_RS28665	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
S58_RS28670	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
S58_RS28675	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
S58_RS28680	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
S58_RS28695	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
S58_RS28705	COG0745	RESPONSE REGULATOR receiver
S58_RS28710	COG0704	Plays a role in the regulation of phosphate uptake
S58_RS28715	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S58_RS28720	COG0581	inorganic phosphate transmembrane transporter activity
S58_RS28725	COG0573	inorganic phosphate transmembrane transporter activity
S58_RS28730	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
S58_RS28765	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
S58_RS28780	COG1309	transcriptional regulator
S58_RS28785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S58_RS28795	COG4451	ribulose bisphosphate carboxylase, small
S58_RS28800	COG1850	ribulose-bisphosphate carboxylase activity
S58_RS28820	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
S58_RS28840	COG0156	8-amino-7-oxononanoate synthase activity
S58_RS28850	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
S58_RS28885	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
S58_RS28890	COG1429	ligase activity, forming nitrogen-metal bonds
S58_RS28895	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
S58_RS28900	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
S58_RS28920	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
S58_RS28925	COG2211	Major facilitator Superfamily
S58_RS28930	COG0644	oxidoreductase
S58_RS28950	COG4251	negative regulation of phosphorylation
S58_RS28955	COG5398	heme oxygenase
S58_RS28985	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
S58_RS28990	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
S58_RS28995	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
S58_RS29000	COG1063	alcohol dehydrogenase
S58_RS29005	COG0500	methyltransferase
S58_RS29010	COG0142	geranyltranstransferase activity
S58_RS29025	COG1562	ergosterol biosynthetic process
S58_RS29030	COG1233	COG1233 Phytoene dehydrogenase and related
S58_RS29045	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
S58_RS29055	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
S58_RS29060	COG2986	histidine ammonia-lyase
S58_RS29065	COG1228	amidohydrolase
S58_RS29085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S58_RS29145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S58_RS29150	COG0492	ferredoxin-NADP+ reductase activity
S58_RS29160	COG0747	negative chemotaxis
S58_RS29165	COG4608	Belongs to the ABC transporter superfamily
S58_RS29170	COG0444	Belongs to the ABC transporter superfamily
S58_RS29175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S58_RS29195	COG2723	6-phospho-beta-galactosidase activity
S58_RS29215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
S58_RS29215	COG0574	Belongs to the PEP-utilizing enzyme family
S58_RS29230	COG2271	Major facilitator Superfamily
S58_RS29235	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
S58_RS29255	COG2205	protein histidine kinase activity
S58_RS29260	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
S58_RS29265	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
S58_RS29270	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
S58_RS29300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S58_RS29315	COG1763	Mo-molybdopterin cofactor biosynthetic process
S58_RS29320	COG0746	molybdenum cofactor guanylyltransferase activity
S58_RS29350	COG4974	Belongs to the 'phage' integrase family
S58_RS29365	COG1196	nuclear chromosome segregation
S58_RS29405	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
S58_RS29410	COG3156	type II secretion system protein K
S58_RS29420	COG2165	general secretion pathway protein
S58_RS29430	COG4970	Tfp pilus assembly protein FimT
S58_RS29435	COG1459	type II secretion system
S58_RS29440	COG1450	Type ii and iii secretion system protein
S58_RS29495	COG4372	Transposase
S58_RS29500	COG2197	response regulator
S58_RS29510	COG2801	Transposase and inactivated derivatives
S58_RS29520	COG1484	DNA-dependent DNA replication
S58_RS29580	COG0156	8-amino-7-oxononanoate synthase activity
S58_RS29595	COG0154	amidase activity
S58_RS29600	COG1473	amidohydrolase
S58_RS29625	COG2084	Dehydrogenase
S58_RS29630	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S58_RS29640	COG0471	metal ion transport
S58_RS29650	COG1024	Enoyl-CoA hydratase
S58_RS29660	COG1234	tRNA 3'-trailer cleavage
S58_RS29710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S58_RS29715	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS29745	COG0482	sulfurtransferase activity
S58_RS29755	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
S58_RS29765	COG1766	The M ring may be actively involved in energy transduction
S58_RS29770	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S58_RS29780	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S58_RS29785	COG2204	response regulator
S58_RS29795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S58_RS29800	COG1116	anion transmembrane transporter activity
S58_RS29805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S58_RS29810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S58_RS29815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S58_RS29830	COG0243	molybdopterin cofactor binding
S58_RS29835	COG3043	anaerobic respiration
S58_RS29840	COG3005	denitrification pathway
S58_RS29845	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
S58_RS29850	COG2326	polyphosphate kinase activity
S58_RS29885	COG0583	DNA-binding transcription factor activity
S58_RS29890	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S58_RS29895	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S58_RS29935	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
S58_RS29940	COG1136	(ABC) transporter
S58_RS29945	COG4591	ABC-type transport system involved in lipoprotein release permease component
S58_RS29975	COG0697	spore germination
S58_RS30000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S58_RS30040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S58_RS30060	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
S58_RS30065	COG0659	secondary active sulfate transmembrane transporter activity
S58_RS30075	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
S58_RS30155	COG1309	transcriptional regulator
S58_RS30160	COG1024	Enoyl-CoA hydratase
S58_RS30195	COG0556	nucleotide-excision repair
S58_RS30215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
S58_RS30265	COG2030	dehydratase
S58_RS30275	COG0012	GTP binding
S58_RS30280	COG0193	aminoacyl-tRNA hydrolase activity
S58_RS30285	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
S58_RS30295	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
S58_RS30315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
S58_RS30330	COG3135	benzoate transporter
S58_RS30335	COG1653	transport
S58_RS30340	COG1175	transmembrane transport
S58_RS30345	COG3833	ABC-type maltose transport systems, permease component
S58_RS30350	COG3920	Histidine kinase
S58_RS30355	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
S58_RS30355	COG3608	succinylglutamate desuccinylase aspartoacylase
S58_RS30365	COG0542	response to heat
S58_RS30390	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
S58_RS30410	COG1942	4-Oxalocrotonate Tautomerase
S58_RS30415	COG0124	histidyl-tRNA synthetase
S58_RS30420	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S58_RS30425	COG1846	Transcriptional regulator
S58_RS30430	COG0745	RESPONSE REGULATOR receiver
S58_RS30445	COG1414	Transcriptional regulator
S58_RS30450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S58_RS30455	COG0179	Fumarylacetoacetate (FAA) hydrolase
S58_RS30490	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
S58_RS30495	COG1278	Cold shock
S58_RS30505	COG0322	excinuclease ABC activity
S58_RS30535	COG1064	alcohol dehydrogenase
S58_RS30545	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
S58_RS30555	COG0314	molybdopterin synthase activity
S58_RS30560	COG2890	protein-(glutamine-N5) methyltransferase activity
S58_RS30565	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S58_RS30595	COG0300	oxidoreductase activity
S58_RS30605	COG0745	RESPONSE REGULATOR receiver
S58_RS30610	COG0196	riboflavin kinase activity
S58_RS30615	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
S58_RS30620	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
S58_RS30630	COG0612	Peptidase, M16
S58_RS30635	COG0612	Peptidase, M16
S58_RS30690	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
S58_RS30695	COG0742	ribosomal rna small subunit methyltransferase
S58_RS30700	COG1187	pseudouridine synthase activity
S58_RS30705	COG0590	tRNA wobble adenosine to inosine editing
S58_RS30715	COG4106	trans-aconitate 2-methyltransferase activity
S58_RS30730	COG0151	Belongs to the GarS family
S58_RS30750	COG1570	exodeoxyribonuclease VII activity
S58_RS30765	COG1663	tetraacyldisaccharide 4'-kinase activity
S58_RS30770	COG1519	Transferase
S58_RS30785	COG1218	3'(2'),5'-bisphosphate nucleotidase
S58_RS30790	COG0312	modulator of DNA gyrase
S58_RS30815	COG1385	rRNA (uridine-N3-)-methyltransferase activity
S58_RS30820	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
S58_RS30825	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
S58_RS30830	COG0463	Glycosyl transferase, family 2
S58_RS30840	COG3416	Protein conserved in bacteria
S58_RS30845	COG1376	ErfK ybiS ycfS ynhG family protein
S58_RS30845	COG1388	LysM domain
S58_RS30860	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
S58_RS30865	COG0459	protein refolding
S58_RS30880	COG1620	l-lactate permease
S58_RS30885	COG4178	(ABC) transporter
S58_RS30900	COG0247	lactate metabolic process
S58_RS30905	COG0277	FAD linked oxidase domain protein
S58_RS30950	COG0277	FAD linked oxidase domain protein
S58_RS30955	COG3474	cytochrome
S58_RS30960	COG0596	Alpha beta hydrolase
S58_RS30975	COG3063	Type IV pilus biogenesis stability protein PilW
S58_RS30980	COG0257	Belongs to the bacterial ribosomal protein bL36 family
S58_RS30995	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
S58_RS31005	COG0583	DNA-binding transcription factor activity
S58_RS31010	COG1741	Belongs to the pirin family
S58_RS31015	COG0655	NAD(P)H dehydrogenase (quinone) activity
S58_RS31025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S58_RS31030	COG1126	abc transporter atp-binding protein
S58_RS31035	COG0765	amino acid transport
S58_RS31040	COG0765	amino acid transport
S58_RS31045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S58_RS31065	COG1902	pentaerythritol trinitrate reductase activity
S58_RS31070	COG2005	Transcriptional regulator
S58_RS31075	COG4221	oxidoreductase activity
S58_RS31135	COG3920	Histidine kinase
S58_RS31170	COG1309	transcriptional regulator
S58_RS31175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S58_RS31195	COG3842	ATPase activity
S58_RS31200	COG1176	ABC-type spermidine putrescine transport system, permease component I
S58_RS31205	COG4149	molybdate abc transporter
S58_RS31220	COG0456	acetyltransferase
S58_RS31270	COG0483	inositol monophosphate 1-phosphatase activity
S58_RS31290	COG1280	lysine exporter protein (LysE YggA)
S58_RS31305	COG2010	Cytochrome c
S58_RS31310	COG3002	Belongs to the UPF0753 family
S58_RS31315	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
S58_RS31320	COG0583	DNA-binding transcription factor activity
S58_RS31345	COG2202	Pas domain
S58_RS31345	COG3920	Histidine kinase
S58_RS31365	COG0071	Belongs to the small heat shock protein (HSP20) family
S58_RS31390	COG0070	glutamate synthase
S58_RS31390	COG0069	glutamate synthase activity
S58_RS31390	COG0067	glutamate synthase
S58_RS31400	COG2162	N-hydroxyarylamine O-acetyltransferase activity
S58_RS31435	COG0330	HflC and HflK could
S58_RS31440	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
S58_RS31450	COG1657	PFAM Prenyltransferase squalene oxidase
S58_RS31455	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S58_RS31495	COG0251	oxidation-reduction process
S58_RS31515	COG0523	cobalamin synthesis protein
S58_RS31520	COG0803	Belongs to the bacterial solute-binding protein 9 family
S58_RS31530	COG1121	(ABC) transporter
S58_RS31540	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S58_RS31545	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
S58_RS31590	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS31605	COG0318	PFAM AMP-dependent synthetase and ligase
S58_RS31615	COG0326	Molecular chaperone. Has ATPase activity
S58_RS31625	COG0346	lactoylglutathione lyase activity
S58_RS31660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S58_RS31670	COG4774	siderophore transport
S58_RS31675	COG4774	siderophore transport
S58_RS31680	COG3128	pkhd-type hydroxylase
S58_RS31690	COG0848	biopolymer transport protein
S58_RS31730	COG1262	PFAM Formylglycine-generating sulfatase enzyme
S58_RS31760	COG4263	nitrous-oxide reductase activity
S58_RS31885	COG4969	Belongs to the N-Me-Phe pilin family
S58_RS31895	COG1459	type II secretion system
S58_RS31900	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
S58_RS31905	COG1450	Type ii and iii secretion system protein
S58_RS31915	COG3511	phospholipase C
S58_RS31935	COG0739	heme binding
S58_RS31935	COG0741	lytic transglycosylase activity
S58_RS31935	COG1196	nuclear chromosome segregation
S58_RS31945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S58_RS31975	COG0811	peptide transport
S58_RS32035	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS32045	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS32060	COG0179	Fumarylacetoacetate (FAA) hydrolase
S58_RS32090	COG5285	phytanoyl-CoA dioxygenase
S58_RS32130	COG0739	heme binding
S58_RS32140	COG0542	response to heat
S58_RS32155	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
S58_RS32170	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
S58_RS32185	COG1376	ErfK ybiS ycfS ynhG family protein
S58_RS32185	COG1388	LysM domain
S58_RS32190	COG0628	permease
S58_RS32215	COG0784	Response regulator, receiver
S58_RS32235	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
S58_RS32240	COG0830	nickel cation binding
S58_RS32245	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
S58_RS32255	COG0804	urea catabolic process
S58_RS32260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
S58_RS32265	COG0832	Belongs to the urease beta subunit family
S58_RS32270	COG0831	urea catabolic process
S58_RS32275	COG0829	nickel cation binding
S58_RS32305	COG0513	Belongs to the DEAD box helicase family
S58_RS32310	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
S58_RS32315	COG1278	Cold shock
S58_RS32355	COG4964	Belongs to the GSP D family
S58_RS32395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
S58_RS32430	COG4172	Belongs to the ABC transporter superfamily
S58_RS32435	COG4239	(ABC) transporter, permease
S58_RS32440	COG4174	ABC transporter (Permease)
S58_RS32445	COG4166	transmembrane transport
S58_RS32450	COG4166	transmembrane transport
S58_RS32455	COG3474	cytochrome
S58_RS32460	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
S58_RS32470	COG0583	DNA-binding transcription factor activity
S58_RS32475	COG0702	epimerase
S58_RS32485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S58_RS32530	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
S58_RS32535	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS32540	COG1960	acyl-CoA dehydrogenase activity
S58_RS32545	COG1960	acyl-CoA dehydrogenase activity
S58_RS32550	COG0183	Belongs to the thiolase family
S58_RS32555	COG0318	PFAM AMP-dependent synthetase and ligase
S58_RS32580	COG0559	Belongs to the binding-protein-dependent transport system permease family
S58_RS32630	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
S58_RS32650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S58_RS32650	COG0318	PFAM AMP-dependent synthetase and ligase
S58_RS32650	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS32650	COG0300	oxidoreductase activity
S58_RS32650	COG3321	synthase
S58_RS32655	COG1024	Enoyl-CoA hydratase
S58_RS32750	COG1024	Enoyl-CoA hydratase
S58_RS32755	COG2197	response regulator
S58_RS32760	COG3916	Acyl-homoserine-lactone synthase
S58_RS32770	COG1960	acyl-CoA dehydrogenase activity
S58_RS32775	COG1960	acyl-CoA dehydrogenase activity
S58_RS32805	COG0183	Belongs to the thiolase family
S58_RS32810	COG0318	PFAM AMP-dependent synthetase and ligase
S58_RS32815	COG0596	Alpha beta hydrolase
S58_RS32835	COG3038	cytochrome b561
S58_RS32840	COG0154	amidase activity
S58_RS32845	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
S58_RS32875	COG0583	DNA-binding transcription factor activity
S58_RS32885	COG1546	Belongs to the CinA family
S58_RS32885	COG1058	Belongs to the CinA family
S58_RS32895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S58_RS32900	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
S58_RS32915	COG0154	amidase activity
S58_RS32925	COG4608	Belongs to the ABC transporter superfamily
S58_RS32930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S58_RS32935	COG0601	transmembrane transport
S58_RS32940	COG0747	negative chemotaxis
S58_RS32945	COG0747	negative chemotaxis
S58_RS33025	COG0601	transmembrane transport
S58_RS33030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S58_RS33035	COG0444	Belongs to the ABC transporter superfamily
S58_RS33080	COG2309	aminopeptidase activity
S58_RS33100	COG0596	Alpha beta hydrolase
S58_RS33120	COG3842	ATPase activity
S58_RS33125	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
S58_RS33130	COG1176	ABC-type spermidine putrescine transport system, permease component I
S58_RS33150	COG0154	amidase activity
S58_RS33160	COG2351	hydroxyisourate hydrolase activity
S58_RS33170	COG1850	ribulose-bisphosphate carboxylase activity
S58_RS33180	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
S58_RS33185	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
S58_RS33195	COG0583	DNA-binding transcription factor activity
S58_RS33200	COG0346	lactoylglutathione lyase activity
S58_RS33205	COG0400	carboxylic ester hydrolase activity
S58_RS33215	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
S58_RS33220	COG0367	asparagine synthase
S58_RS33225	COG0121	glutamine amidotransferase
S58_RS33230	COG0583	DNA-binding transcription factor activity
S58_RS33240	COG1346	cytolysis
S58_RS33280	COG1032	radical SAM domain protein
S58_RS33320	COG0667	Aldo Keto reductase
S58_RS33340	COG2205	protein histidine kinase activity
S58_RS33345	COG0745	RESPONSE REGULATOR receiver
S58_RS33355	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
S58_RS33390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
S58_RS33405	COG0535	radical SAM domain protein
S58_RS33420	COG1522	sequence-specific DNA binding
S58_RS33425	COG3391	amine dehydrogenase activity
S58_RS33435	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S58_RS33440	COG2010	Cytochrome c
S58_RS33445	COG3901	Regulator of nitric oxide reductase transcription
S58_RS33445	COG0348	domain, Protein
S58_RS33465	COG0826	peptidase U32
S58_RS33470	COG3154	lipid carrier protein
S58_RS33475	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
S58_RS33480	COG0163	prenyltransferase activity
S58_RS33490	COG3852	Histidine kinase
S58_RS33500	COG0594	ribonuclease P activity
S58_RS33505	COG0706	membrane insertase activity
S58_RS33510	COG0218	Necessary for normal cell division and for the maintenance of normal septation
S58_RS33520	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
S58_RS33535	COG2171	N-acyltransferase activity
S58_RS33545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S58_RS33560	COG0101	tRNA pseudouridine synthase activity
S58_RS33565	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
S58_RS33570	COG0242	peptide deformylase activity
S58_RS33585	COG2223	nitrite transmembrane transporter activity
S58_RS33595	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
S58_RS33600	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
S58_RS33605	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
S58_RS33620	COG1522	sequence-specific DNA binding
S58_RS33635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S58_RS33640	COG3577	Aspartyl protease
S58_RS33645	COG1643	Atp-dependent helicase
S58_RS33650	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S58_RS33660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S58_RS33660	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S58_RS33670	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
S58_RS33690	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
S58_RS33705	COG0058	SHG alpha-glucan phosphorylase activity
S58_RS33715	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
S58_RS33725	COG0745	RESPONSE REGULATOR receiver
S58_RS33730	COG2205	protein histidine kinase activity
S58_RS33740	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S58_RS33740	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
S58_RS33750	COG0488	(ABC) transporter
S58_RS33760	COG0481	GTPase activity
S58_RS33765	COG0583	DNA-binding transcription factor activity
S58_RS33790	COG5001	Diguanylate cyclase
S58_RS33795	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
S58_RS33805	COG3263	regulation of cellular component size
S58_RS33810	COG3264	Mechanosensitive ion channel
S58_RS33810	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
S58_RS33830	COG1404	Belongs to the peptidase S8 family
S58_RS33840	COG0024	Methionine aminopeptidase
S58_RS33855	COG2814	Major facilitator Superfamily
S58_RS33860	COG2020	methyltransferase activity
S58_RS33870	COG2003	Belongs to the UPF0758 family
S58_RS33875	COG0582	viral genome integration into host DNA
S58_RS33880	COG1074	ATP-dependent DNA helicase activity
S58_RS33940	COG0693	protein deglycase activity
S58_RS33945	COG4977	sequence-specific DNA binding
S58_RS33945	COG1917	Cupin 2, conserved barrel domain protein
S58_RS33975	COG0697	spore germination
S58_RS33980	COG0436	Aminotransferase
S58_RS34000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S58_RS34005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S58_RS34015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S58_RS34035	COG1253	flavin adenine dinucleotide binding
S58_RS34045	COG1116	anion transmembrane transporter activity
S58_RS34050	COG0069	glutamate synthase activity
S58_RS34075	COG1301	dicarboxylic acid transport
S58_RS34105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S58_RS34130	COG0840	transmembrane signaling receptor activity
S58_RS34130	COG2972	Histidine kinase
S58_RS34135	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
S58_RS34140	COG0840	transmembrane signaling receptor activity
S58_RS34140	COG2972	Histidine kinase
S58_RS34145	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
S58_RS34160	COG1858	cytochrome C peroxidase
S58_RS34170	COG2183	response to ionizing radiation
S58_RS34185	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
S58_RS34210	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S58_RS34270	COG1960	acyl-CoA dehydrogenase activity
S58_RS34275	COG1024	Enoyl-CoA hydratase
S58_RS34285	COG1024	Enoyl-CoA hydratase
S58_RS34315	COG2207	Transcriptional regulator
S58_RS34315	COG0662	Cupin 2, conserved barrel domain protein
S58_RS34345	COG0227	Belongs to the bacterial ribosomal protein bL28 family
S58_RS34365	COG1278	Cold shock
S58_RS34370	COG0828	Belongs to the bacterial ribosomal protein bS21 family
S58_RS34380	COG4172	Belongs to the ABC transporter superfamily
S58_RS34385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S58_RS34415	COG1902	pentaerythritol trinitrate reductase activity
S58_RS34440	COG0372	Belongs to the citrate synthase family
S58_RS34445	COG0372	Belongs to the citrate synthase family
S58_RS34460	COG4536	flavin adenine dinucleotide binding
S58_RS34465	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
S58_RS34470	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
S58_RS34480	COG4974	Belongs to the 'phage' integrase family
S58_RS34485	COG0825	malonyl-CoA metabolic process
S58_RS34490	COG3034	peptidoglycan biosynthetic process
S58_RS34500	COG1959	2 iron, 2 sulfur cluster binding
S58_RS34520	COG4993	Dehydrogenase
S58_RS34525	COG5001	Diguanylate cyclase
S58_RS34525	COG3300	MHYT domain
S58_RS34540	COG0318	PFAM AMP-dependent synthetase and ligase
S58_RS34550	COG0584	glycerophosphoryl diester phosphodiesterase
S58_RS34570	COG0653	protein targeting
S58_RS34575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S58_RS34580	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
S58_RS34595	COG0494	nUDIX hydrolase
S58_RS34605	COG1040	competence protein
S58_RS34610	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
S58_RS34640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
S58_RS34650	COG0527	aspartate kinase activity
S58_RS34655	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
S58_RS34660	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
S58_RS34665	COG2890	protein-(glutamine-N5) methyltransferase activity
S58_RS34680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S58_RS34690	COG5001	Diguanylate cyclase
S58_RS34690	COG3300	MHYT domain
S58_RS34695	COG0697	spore germination
S58_RS34710	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
S58_RS34715	COG5001	Diguanylate cyclase
S58_RS34715	COG3300	MHYT domain
S58_RS34730	COG0333	Belongs to the bacterial ribosomal protein bL32 family
S58_RS34735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S58_RS34740	COG0142	geranyltranstransferase activity
S58_RS34770	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
S58_RS34780	COG0735	belongs to the Fur family
S58_RS34790	COG1566	PFAM secretion protein HlyD family protein
S58_RS34795	COG2814	Major facilitator Superfamily
S58_RS34800	COG2268	Band 7 protein
S58_RS34820	COG3485	protocatechuate 3,4-dioxygenase
S58_RS34830	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
S58_RS34855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S58_RS34865	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
S58_RS34880	COG0683	leucine binding
S58_RS34885	COG0740	serine-type endopeptidase activity
S58_RS34905	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
S58_RS34910	COG2202	Pas domain
S58_RS34910	COG2200	EAL domain
S58_RS34910	COG2199	diguanylate cyclase activity
S58_RS34940	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
S58_RS34960	COG1482	cell wall glycoprotein biosynthetic process
S58_RS34995	COG0366	Alpha amylase catalytic
S58_RS35000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S58_RS35035	COG1742	UPF0060 membrane protein
S58_RS35070	COG1028	Short-chain dehydrogenase reductase Sdr
S58_RS35080	COG5001	Diguanylate cyclase
S58_RS35110	COG5001	Diguanylate cyclase
S58_RS35155	COG5654	RES domain protein
S58_RS35160	COG5642	Protein of unknown function (DUF2384)
S58_RS35240	COG2856	Zn peptidase
S58_RS35335	COG0477	Major facilitator Superfamily
S58_RS35345	COG4191	Histidine kinase
S58_RS35365	COG4792	protein secretion
S58_RS35375	COG4794	Type iii secretion
S58_RS35380	COG4790	Type iii secretion
S58_RS35385	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S58_RS35395	COG1157	protein secretion by the type III secretion system
S58_RS35400	COG1317	bacterial-type flagellum organization
S58_RS35440	COG4789	Type iii secretion
S58_RS35450	COG4964	Belongs to the GSP D family
S58_RS35535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S58_RS35540	COG1309	transcriptional regulator
S58_RS35550	COG0784	Response regulator, receiver
S58_RS35550	COG4191	Histidine kinase
S58_RS35570	COG0842	Transport permease protein
S58_RS35575	COG1129	ABC transporter
S58_RS35575	COG0842	Transport permease protein
S58_RS35580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S58_RS35610	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
S58_RS35680	COG0412	Dienelactone hydrolase
S58_RS35685	COG1596	polysaccharide export
S58_RS35690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S58_RS35700	COG0268	Binds directly to 16S ribosomal RNA
S58_RS35720	COG3300	MHYT domain
S58_RS35720	COG5001	Diguanylate cyclase
S58_RS35740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S58_RS35775	COG0739	heme binding
S58_RS35775	COG1196	nuclear chromosome segregation
S58_RS35775	COG0741	lytic transglycosylase activity
S58_RS35810	COG2515	1-aminocyclopropane-1-carboxylate deaminase
S58_RS35815	COG2515	1-aminocyclopropane-1-carboxylate deaminase
S58_RS35845	COG3932	Exopolysaccharide synthesis, ExoD
S58_RS35890	COG3916	Acyl-homoserine-lactone synthase
S58_RS35940	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine