locus-tag	class	description
FOA43_000001	COG2814	Major facilitator Superfamily
FOA43_000002	COG2814	Major facilitator Superfamily
FOA43_000003	COG3250	beta-galactosidase activity
FOA43_000004	COG0833	amino acid
FOA43_000010	COG0515	serine threonine protein kinase
FOA43_000021	COG0546	phosphoglycolate phosphatase activity
FOA43_000023	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FOA43_000026	COG1051	belongs to the nudix hydrolase family
FOA43_000028	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FOA43_000036	COG0142	geranyltranstransferase activity
FOA43_000038	COG0481	GTPase activity
FOA43_000048	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FOA43_000049	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FOA43_000051	COG0105	UTP biosynthetic process
FOA43_000060	COG0354	folic acid binding
FOA43_000070	COG0515	serine threonine protein kinase
FOA43_000072	COG2815	serine threonine protein kinase
FOA43_000072	COG0515	serine threonine protein kinase
FOA43_000075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FOA43_000075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FOA43_000076	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FOA43_000084	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FOA43_000085	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FOA43_000088	COG0006	proline dipeptidase activity
FOA43_000104	COG0656	L-ascorbic acid biosynthetic process
FOA43_000105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FOA43_000109	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FOA43_000111	COG0089	rRNA binding
FOA43_000112	COG0039	L-malate dehydrogenase activity
FOA43_000126	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FOA43_000126	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FOA43_000138	COG0126	phosphoglycerate kinase activity
FOA43_000142	COG0833	amino acid
FOA43_000150	COG0492	ferredoxin-NADP+ reductase activity
FOA43_000151	COG0481	GTPase activity
FOA43_000168	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOA43_000168	COG0022	dehydrogenase e1 component
FOA43_000169	COG1643	Atp-dependent helicase
FOA43_000173	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FOA43_000197	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FOA43_000203	COG0515	serine threonine protein kinase
FOA43_000209	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FOA43_000215	COG0517	IMP dehydrogenase activity
FOA43_000215	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FOA43_000216	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FOA43_000216	COG2124	cytochrome p450
FOA43_000220	COG0473	3-isopropylmalate dehydrogenase activity
FOA43_000229	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FOA43_000245	COG1028	Short-chain dehydrogenase reductase Sdr
FOA43_000248	COG2271	Major facilitator Superfamily
FOA43_000253	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FOA43_000256	COG0515	serine threonine protein kinase
FOA43_000256	COG2815	serine threonine protein kinase
FOA43_000260	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FOA43_000263	COG0477	Major facilitator Superfamily
FOA43_000266	COG0402	S-adenosylhomocysteine deaminase activity
FOA43_000268	COG3265	gluconokinase activity
FOA43_000269	COG0515	serine threonine protein kinase
FOA43_000292	COG0006	proline dipeptidase activity
FOA43_000298	COG0515	serine threonine protein kinase
FOA43_000299	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FOA43_000304	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
FOA43_000308	COG1012	belongs to the aldehyde dehydrogenase family
FOA43_000309	COG0137	argininosuccinate synthase activity
FOA43_000312	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOA43_000312	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOA43_000317	COG0166	Belongs to the GPI family
FOA43_000326	COG1064	alcohol dehydrogenase
FOA43_000328	COG1716	ATPase activity
FOA43_000328	COG1131	(ABC) transporter
FOA43_000328	COG0842	Transport permease protein
FOA43_000331	COG0588	phosphoglycerate mutase activity
FOA43_000334	COG0402	S-adenosylhomocysteine deaminase activity
FOA43_000363	COG1227	inorganic diphosphatase activity
FOA43_000365	COG0460	homoserine dehydrogenase
FOA43_000365	COG0527	aspartate kinase activity
FOA43_000383	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FOA43_000386	COG0154	amidase activity
FOA43_000389	COG1012	belongs to the aldehyde dehydrogenase family
FOA43_000397	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FOA43_000398	COG0529	Catalyzes the synthesis of activated sulfate
FOA43_000398	COG2046	Belongs to the sulfate adenylyltransferase family
FOA43_000400	COG1404	Belongs to the peptidase S8 family
FOA43_000401	COG4770	biotin carboxylase activity
FOA43_000413	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
FOA43_000424	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
FOA43_000426	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FOA43_000427	COG0037	tRNA processing
FOA43_000431	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOA43_000440	COG1490	D-aminoacyl-tRNA deacylase activity
FOA43_000450	COG1063	alcohol dehydrogenase
FOA43_000451	COG0038	chloride channel
FOA43_000455	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FOA43_000460	COG1012	belongs to the aldehyde dehydrogenase family
FOA43_000461	COG0233	cytoplasmic translational termination
FOA43_000467	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FOA43_000474	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FOA43_000480	COG0585	pseudouridine synthase activity
FOA43_000486	COG2814	Major facilitator Superfamily
FOA43_000487	COG1122	ATPase activity
FOA43_000491	COG1113	amino acid transport
FOA43_000502	COG0179	Fumarylacetoacetate (FAA) hydrolase
FOA43_000505	COG0033	Phosphoglucomutase
FOA43_000506	COG1448	Aminotransferase
FOA43_000508	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FOA43_000513	COG0326	Molecular chaperone. Has ATPase activity
FOA43_000520	COG0488	(ABC) transporter
FOA43_000536	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FOA43_000567	COG0477	Major facilitator Superfamily
FOA43_000569	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FOA43_000570	COG0167	dihydroorotate dehydrogenase activity
FOA43_000574	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FOA43_000589	COG0459	protein refolding
FOA43_000594	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FOA43_000596	COG0833	amino acid
FOA43_000612	COG2843	Capsule synthesis protein
FOA43_000618	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FOA43_000619	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FOA43_000622	COG2815	serine threonine protein kinase
FOA43_000622	COG0515	serine threonine protein kinase
FOA43_000627	COG2815	serine threonine protein kinase
FOA43_000627	COG0515	serine threonine protein kinase
FOA43_000639	COG0688	phosphatidylethanolamine metabolic process
FOA43_000641	COG0109	protoheme IX farnesyltransferase activity
FOA43_000646	COG0217	transcriptional regulatory protein
FOA43_000670	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FOA43_000671	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FOA43_000675	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FOA43_000682	COG2814	Major facilitator Superfamily
FOA43_000687	COG0006	proline dipeptidase activity
FOA43_000690	COG0484	heat shock protein binding
FOA43_000693	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FOA43_000702	COG0028	Belongs to the TPP enzyme family
FOA43_000704	COG0459	protein refolding
FOA43_000711	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FOA43_000729	COG0149	triose-phosphate isomerase activity
FOA43_000730	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FOA43_000732	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FOA43_000744	COG0443	Heat shock 70 kDa protein
FOA43_000749	COG0667	Aldo Keto reductase
FOA43_000750	COG1028	Short-chain dehydrogenase reductase Sdr
FOA43_000758	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FOA43_000768	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FOA43_000775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FOA43_000776	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FOA43_000793	COG1362	aminopeptidase activity
FOA43_000795	COG2313	pseudouridylate synthase activity
FOA43_000803	COG0408	coproporphyrinogen oxidase activity
FOA43_000806	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FOA43_000812	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FOA43_000820	COG0525	valine-tRNA ligase activity
FOA43_000822	COG0515	serine threonine protein kinase
FOA43_000826	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FOA43_000837	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FOA43_000838	COG0165	Argininosuccinate lyase
FOA43_000851	COG0156	8-amino-7-oxononanoate synthase activity
FOA43_000855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FOA43_000862	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FOA43_000868	COG0459	protein refolding
FOA43_000870	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FOA43_000874	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FOA43_000876	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FOA43_000887	COG0443	Heat shock 70 kDa protein
FOA43_000891	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FOA43_000896	COG0515	serine threonine protein kinase
FOA43_000897	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FOA43_000907	COG3118	belongs to the thioredoxin family
FOA43_000908	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FOA43_000944	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FOA43_000947	COG0515	serine threonine protein kinase
FOA43_000947	COG0457	Tetratricopeptide repeat
FOA43_000951	COG0423	glycine-tRNA ligase activity
FOA43_000952	COG0515	serine threonine protein kinase
FOA43_000952	COG2815	serine threonine protein kinase
FOA43_000959	COG0187	DNA topoisomerase II activity
FOA43_000962	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FOA43_000965	COG0515	serine threonine protein kinase
FOA43_000965	COG2815	serine threonine protein kinase
FOA43_000974	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FOA43_000980	COG3158	transport of potassium into the cell
FOA43_000983	COG1185	polyribonucleotide nucleotidyltransferase activity
FOA43_001004	COG0513	Belongs to the DEAD box helicase family
FOA43_001019	COG1025	Belongs to the peptidase M16 family
FOA43_001025	COG0723	plastoquinol--plastocyanin reductase activity
FOA43_001029	COG2119	membrane
FOA43_001033	COG2815	serine threonine protein kinase
FOA43_001033	COG0515	serine threonine protein kinase
FOA43_001045	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FOA43_001064	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FOA43_001068	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FOA43_001077	COG0557	exoribonuclease II activity
FOA43_001089	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FOA43_001091	COG0644	oxidoreductase
FOA43_001091	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
FOA43_001100	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FOA43_001107	COG0012	GTP binding
FOA43_001110	COG0052	Belongs to the universal ribosomal protein uS2 family
FOA43_001115	COG0656	L-ascorbic acid biosynthetic process
FOA43_001119	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FOA43_001120	COG0135	phosphoribosylanthranilate isomerase activity
FOA43_001123	COG0037	tRNA processing
FOA43_001131	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FOA43_001142	COG4221	oxidoreductase activity
FOA43_001158	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FOA43_001159	COG0484	heat shock protein binding
FOA43_001160	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FOA43_001166	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FOA43_001168	COG0489	protein tyrosine kinase activity
FOA43_001170	COG0386	Belongs to the glutathione peroxidase family
FOA43_001171	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FOA43_001171	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FOA43_001174	COG0366	Alpha amylase catalytic
FOA43_001175	COG2814	Major facilitator Superfamily
FOA43_001177	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOA43_001177	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOA43_001180	COG2814	Major facilitator Superfamily
FOA43_001183	COG0481	GTPase activity
FOA43_001185	COG1012	belongs to the aldehyde dehydrogenase family
FOA43_001199	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FOA43_001217	COG0363	glucosamine-6-phosphate deaminase activity
FOA43_001222	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FOA43_001225	COG1716	ATPase activity
FOA43_001225	COG1131	(ABC) transporter
FOA43_001225	COG0842	Transport permease protein
FOA43_001231	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FOA43_001236	COG0649	NAD binding
FOA43_001239	COG0706	membrane insertase activity
FOA43_001247	COG0588	phosphoglycerate mutase activity
FOA43_001259	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FOA43_001263	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FOA43_001276	COG2814	Major facilitator Superfamily
FOA43_001297	COG1902	pentaerythritol trinitrate reductase activity
FOA43_001298	COG1902	pentaerythritol trinitrate reductase activity
FOA43_001312	COG4221	oxidoreductase activity
FOA43_001336	COG0484	heat shock protein binding
FOA43_001340	COG0647	UMP catabolic process
FOA43_001341	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FOA43_001348	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FOA43_001349	COG0085	RNA polymerase activity
FOA43_001357	COG2124	cytochrome p450
FOA43_001359	COG0330	HflC and HflK could
FOA43_001364	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FOA43_001377	COG1196	nuclear chromosome segregation
FOA43_001379	COG0142	geranyltranstransferase activity
FOA43_001380	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FOA43_001386	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FOA43_001387	COG0300	oxidoreductase activity
FOA43_001398	COG2814	Major facilitator Superfamily
FOA43_001407	COG0367	asparagine synthase
FOA43_001415	COG2897	thiosulfate sulfurtransferase activity
FOA43_001425	COG1064	alcohol dehydrogenase
FOA43_001432	COG2815	serine threonine protein kinase
FOA43_001432	COG0515	serine threonine protein kinase
FOA43_001435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FOA43_001437	COG2815	serine threonine protein kinase
FOA43_001437	COG0515	serine threonine protein kinase
FOA43_001444	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FOA43_001448	COG0672	)-iron permease
FOA43_001455	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FOA43_001475	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FOA43_001480	COG1012	belongs to the aldehyde dehydrogenase family
FOA43_001484	COG0049	tRNA binding
FOA43_001513	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FOA43_001517	COG4178	(ABC) transporter
FOA43_001520	COG0512	Glutamine amidotransferase of anthranilate synthase
FOA43_001520	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FOA43_001527	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FOA43_001533	COG0084	hydrolase, TatD family'
FOA43_001538	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FOA43_001552	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FOA43_001553	COG0463	Glycosyl transferase, family 2
FOA43_001556	COG1069	ribulokinase activity
FOA43_001570	COG2815	serine threonine protein kinase
FOA43_001570	COG0515	serine threonine protein kinase
FOA43_001574	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FOA43_001576	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FOA43_001579	COG1063	alcohol dehydrogenase
FOA43_001580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FOA43_001583	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FOA43_001593	COG0477	Major facilitator Superfamily
FOA43_001605	COG0004	ammonium transporteR
FOA43_001607	COG2175	clavaminate synthase activity
FOA43_001608	COG0277	FAD linked oxidase domain protein
FOA43_001609	COG2175	clavaminate synthase activity
FOA43_001610	COG0436	Aminotransferase
FOA43_001614	COG2175	clavaminate synthase activity
FOA43_001620	COG2815	serine threonine protein kinase
FOA43_001620	COG0515	serine threonine protein kinase
FOA43_001627	COG1253	flavin adenine dinucleotide binding
FOA43_001640	COG1482	cell wall glycoprotein biosynthetic process
FOA43_001653	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FOA43_001655	COG1012	belongs to the aldehyde dehydrogenase family
FOA43_001657	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FOA43_001658	COG1914	H( )-stimulated, divalent metal cation uptake system
FOA43_001662	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FOA43_001666	COG0285	dihydrofolate synthase activity
FOA43_001677	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FOA43_001682	COG0495	leucyl-tRNA aminoacylation
FOA43_001683	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FOA43_001684	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FOA43_001685	COG2814	Major facilitator Superfamily
FOA43_001687	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FOA43_001689	COG1132	(ABC) transporter
FOA43_001691	COG1132	(ABC) transporter
FOA43_001692	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FOA43_001695	COG1914	H( )-stimulated, divalent metal cation uptake system
FOA43_001697	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FOA43_001709	COG0450	alkyl hydroperoxide reductase
FOA43_001713	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FOA43_001720	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FOA43_001727	COG0023	Translation Initiation Factor
FOA43_001730	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FOA43_001731	COG0513	Belongs to the DEAD box helicase family
FOA43_001732	COG0101	tRNA pseudouridine synthase activity
FOA43_001754	COG0489	protein tyrosine kinase activity
FOA43_001755	COG0493	'glutamate synthase
FOA43_001755	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FOA43_001759	COG0352	thiamine-phosphate diphosphorylase activity
FOA43_001759	COG0351	phosphomethylpyrimidine kinase
FOA43_001768	COG0513	Belongs to the DEAD box helicase family
FOA43_001769	COG0513	Belongs to the DEAD box helicase family
FOA43_001772	COG0515	serine threonine protein kinase
FOA43_001773	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FOA43_001782	COG2814	Major facilitator Superfamily
FOA43_001783	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FOA43_001793	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FOA43_001794	COG0659	secondary active sulfate transmembrane transporter activity
FOA43_001800	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FOA43_001809	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FOA43_001823	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FOA43_001832	COG0515	serine threonine protein kinase
FOA43_001832	COG2815	serine threonine protein kinase
FOA43_001838	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FOA43_001840	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FOA43_001850	COG0393	Putative heavy-metal-binding
FOA43_001853	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FOA43_001862	COG1063	alcohol dehydrogenase
FOA43_001870	COG0154	amidase activity
FOA43_001877	COG0154	amidase activity
FOA43_001879	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FOA43_001884	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FOA43_001891	COG0010	Belongs to the arginase family
FOA43_001895	COG0004	ammonium transporteR
FOA43_001899	COG0515	serine threonine protein kinase
FOA43_001899	COG3064	Membrane
FOA43_001899	COG4991	sh3 domain protein
FOA43_001901	COG0459	protein refolding
FOA43_001928	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FOA43_001930	COG0484	heat shock protein binding
FOA43_001934	COG1902	pentaerythritol trinitrate reductase activity
FOA43_001941	COG0366	Alpha amylase catalytic
FOA43_001942	COG2814	Major facilitator Superfamily
FOA43_001951	COG2814	Major facilitator Superfamily
FOA43_001953	COG0667	Aldo Keto reductase
FOA43_001956	COG1064	alcohol dehydrogenase
FOA43_001959	COG2814	Major facilitator Superfamily
FOA43_001962	COG2814	Major facilitator Superfamily
FOA43_001963	COG3250	beta-galactosidase activity
FOA43_001965	COG0798	PFAM Bile acid sodium symporter
FOA43_001967	COG4948	Mandelate Racemase Muconate Lactonizing
FOA43_001970	COG2814	Major facilitator Superfamily
FOA43_001971	COG1028	Short-chain dehydrogenase reductase Sdr
FOA43_001974	COG4948	Mandelate Racemase Muconate Lactonizing
FOA43_001997	COG1012	belongs to the aldehyde dehydrogenase family
FOA43_002000	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FOA43_002001	COG0515	serine threonine protein kinase
FOA43_002002	COG2816	NAD+ diphosphatase activity
FOA43_002005	COG0107	imidazoleglycerol-phosphate synthase activity
FOA43_002011	COG2815	serine threonine protein kinase
FOA43_002011	COG0515	serine threonine protein kinase
FOA43_002012	COG0513	Belongs to the DEAD box helicase family
FOA43_002016	COG0318	PFAM AMP-dependent synthetase and ligase
FOA43_002017	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FOA43_002019	COG0564	pseudouridine synthase activity
FOA43_002021	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FOA43_002026	COG2135	peptidase activity
FOA43_002047	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FOA43_002052	COG0572	uridine kinase
FOA43_002057	COG0039	L-malate dehydrogenase activity
FOA43_002058	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
FOA43_002060	COG0428	transporter
FOA43_002061	COG1132	(ABC) transporter
FOA43_002062	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FOA43_002068	COG0316	Belongs to the HesB IscA family
FOA43_002072	COG0515	serine threonine protein kinase
FOA43_002072	COG2815	serine threonine protein kinase
FOA43_002079	COG0131	Imidazoleglycerol-phosphate dehydratase
FOA43_002081	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FOA43_002087	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FOA43_002091	COG0469	pyruvate kinase activity
FOA43_002093	COG1999	signal sequence binding
FOA43_002105	COG0509	glycine decarboxylation via glycine cleavage system
FOA43_002106	COG0271	Belongs to the BolA IbaG family
FOA43_002114	COG1785	Belongs to the alkaline phosphatase family
FOA43_002120	COG0612	Peptidase, M16
FOA43_002123	COG1185	polyribonucleotide nucleotidyltransferase activity
FOA43_002133	COG0604	alcohol dehydrogenase
FOA43_002136	COG1643	Atp-dependent helicase
FOA43_002138	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FOA43_002140	COG2233	PERMEase
FOA43_002141	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FOA43_002142	COG0724	RNA recognition motif
FOA43_002154	COG0542	response to heat
FOA43_002158	COG2815	serine threonine protein kinase
FOA43_002158	COG0515	serine threonine protein kinase
FOA43_002161	COG0515	serine threonine protein kinase
FOA43_002164	COG1234	tRNA 3'-trailer cleavage
FOA43_002167	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FOA43_002177	COG0070	glutamate synthase
FOA43_002177	COG0069	glutamate synthase activity
FOA43_002177	COG0067	glutamate synthase
FOA43_002193	COG0251	oxidation-reduction process
FOA43_002197	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FOA43_002205	COG0138	bifunctional purine biosynthesis protein purh
FOA43_002211	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
FOA43_002211	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FOA43_002213	COG0235	Class ii aldolase
FOA43_002215	COG0572	uridine kinase
FOA43_002219	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FOA43_002231	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FOA43_002233	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FOA43_002234	COG0039	L-malate dehydrogenase activity
FOA43_002254	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FOA43_002257	COG1028	Short-chain dehydrogenase reductase Sdr
FOA43_002267	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FOA43_002267	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FOA43_002269	COG0003	Pfam Anion-transporting ATPase
FOA43_002284	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FOA43_002294	COG0842	Transport permease protein
FOA43_002294	COG1716	ATPase activity
FOA43_002294	COG1131	(ABC) transporter
FOA43_002312	COG0049	tRNA binding
FOA43_002317	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FOA43_002330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FOA43_002336	COG3844	kynureninase activity
FOA43_002341	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FOA43_002344	COG0191	fructose-bisphosphate aldolase activity
FOA43_002347	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FOA43_002354	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FOA43_002361	COG3579	cysteine-type endopeptidase activity
FOA43_002362	COG2264	protein methyltransferase activity
FOA43_002370	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FOA43_002372	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FOA43_002377	COG2271	Major facilitator Superfamily
FOA43_002392	COG0237	dephospho-CoA kinase activity
FOA43_002400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FOA43_002402	COG2815	serine threonine protein kinase
FOA43_002402	COG0515	serine threonine protein kinase
FOA43_002405	COG0482	sulfurtransferase activity
FOA43_002411	COG0302	gtp cyclohydrolase
FOA43_002413	COG4284	Utp--glucose-1-phosphate uridylyltransferase
FOA43_002414	COG0058	SHG alpha-glucan phosphorylase activity
FOA43_002438	COG0012	GTP binding
FOA43_002440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FOA43_002446	COG0617	tRNA 3'-terminal CCA addition
FOA43_002460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FOA43_002462	COG0667	Aldo Keto reductase
FOA43_002484	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FOA43_002485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FOA43_002490	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FOA43_002491	COG0017	Asparaginyl-tRNA synthetase
FOA43_002495	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FOA43_002499	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FOA43_002509	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FOA43_002511	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FOA43_002519	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FOA43_002521	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FOA43_002521	COG0519	Catalyzes the synthesis of GMP from XMP
FOA43_002529	COG0833	amino acid
FOA43_002531	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FOA43_002559	COG0656	L-ascorbic acid biosynthetic process
FOA43_002567	COG2814	Major facilitator Superfamily
FOA43_002568	COG2814	Major facilitator Superfamily
FOA43_002569	COG3961	Belongs to the TPP enzyme family
FOA43_002578	COG0626	cystathionine gamma-synthase activity
FOA43_002588	COG0626	cystathionine gamma-synthase activity
FOA43_002594	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FOA43_002597	COG0842	Transport permease protein
FOA43_002597	COG1131	(ABC) transporter
FOA43_002597	COG1716	ATPase activity
FOA43_002636	COG1328	CTP reductase activity
FOA43_002636	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FOA43_002641	COG2814	Major facilitator Superfamily
FOA43_002641	COG0477	Major facilitator Superfamily
FOA43_002645	COG1953	Uracil, thiamine, allantoin
FOA43_002647	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FOA43_002649	COG2814	Major facilitator Superfamily
FOA43_002659	COG0009	L-threonylcarbamoyladenylate synthase
FOA43_002660	COG3118	belongs to the thioredoxin family
FOA43_002666	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FOA43_002676	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FOA43_002680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FOA43_002683	COG0656	L-ascorbic acid biosynthetic process
FOA43_002694	COG2814	Major facilitator Superfamily
FOA43_002707	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FOA43_002710	COG2271	Major facilitator Superfamily
FOA43_002713	COG0515	serine threonine protein kinase
FOA43_002717	COG0083	homoserine kinase activity
FOA43_002727	COG1028	Short-chain dehydrogenase reductase Sdr
FOA43_002733	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FOA43_002739	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FOA43_002741	COG0557	exoribonuclease II activity
FOA43_002750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FOA43_002753	COG1902	pentaerythritol trinitrate reductase activity
FOA43_002755	COG0417	DNA replication proofreading
FOA43_002762	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FOA43_002765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FOA43_002767	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FOA43_002779	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FOA43_002780	COG2814	Major facilitator Superfamily
FOA43_002788	COG0123	including yeast histone deacetylase and acetoin utilization protein
FOA43_002790	COG1162	GTPase activity
FOA43_002805	COG0443	Heat shock 70 kDa protein
FOA43_002806	COG0513	Belongs to the DEAD box helicase family
FOA43_002821	COG0193	aminoacyl-tRNA hydrolase activity
FOA43_002825	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FOA43_002845	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FOA43_002858	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FOA43_002860	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FOA43_002861	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FOA43_002862	COG1085	galactose-1-phosphate uridylyltransferase
FOA43_002863	COG2814	Major facilitator Superfamily
FOA43_002864	COG0443	Heat shock 70 kDa protein
FOA43_002877	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FOA43_002877	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FOA43_002886	COG0251	oxidation-reduction process
FOA43_002887	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FOA43_002890	COG1132	(ABC) transporter
FOA43_002893	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FOA43_002894	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FOA43_002896	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FOA43_002897	COG0459	protein refolding
FOA43_002904	COG0833	amino acid
FOA43_002905	COG0833	amino acid
FOA43_002910	COG0626	cystathionine gamma-synthase activity
FOA43_002913	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FOA43_002917	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FOA43_002918	COG5398	heme oxygenase
FOA43_002921	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FOA43_002925	COG0285	dihydrofolate synthase activity
FOA43_002928	COG1231	oxidoreductase activity
FOA43_002931	COG5265	(ABC) transporter
FOA43_002937	COG3266	domain, Protein
FOA43_002937	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FOA43_002939	COG2271	Major facilitator Superfamily
FOA43_002941	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FOA43_002946	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FOA43_002957	COG1774	PSP1 C-terminal conserved region
FOA43_002958	COG2116	formate transmembrane transporter activity
FOA43_002961	COG0489	protein tyrosine kinase activity
FOA43_002967	COG3961	Belongs to the TPP enzyme family
FOA43_002976	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FOA43_002978	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FOA43_002988	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FOA43_002991	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FOA43_002994	COG1063	alcohol dehydrogenase
FOA43_002997	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FOA43_002998	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FOA43_003008	COG0077	Prephenate dehydratase
FOA43_003008	COG1605	Chorismate mutase
FOA43_003013	COG0529	Catalyzes the synthesis of activated sulfate
FOA43_003019	COG0417	DNA replication proofreading
FOA43_003023	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FOA43_003026	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FOA43_003033	COG0076	glutamate decarboxylase activity
FOA43_003034	COG1069	ribulokinase activity
FOA43_003047	COG0180	Tryptophanyl-tRNA synthetase
FOA43_003058	COG0484	heat shock protein binding
FOA43_003071	COG0656	L-ascorbic acid biosynthetic process
FOA43_003072	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FOA43_003093	COG0308	aminopeptidase N
FOA43_003094	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FOA43_003109	COG0473	3-isopropylmalate dehydrogenase activity
FOA43_003115	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FOA43_003120	COG5277	cytoskeleton organization
FOA43_003121	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FOA43_003127	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FOA43_003131	COG0557	exoribonuclease II activity
FOA43_003132	COG0488	(ABC) transporter
FOA43_003134	COG0484	heat shock protein binding
FOA43_003136	COG0114	fumarate hydratase activity
FOA43_003137	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FOA43_003151	COG2814	Major facilitator Superfamily
FOA43_003152	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FOA43_003157	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FOA43_003159	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FOA43_003178	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
FOA43_003180	COG1643	Atp-dependent helicase
FOA43_003181	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FOA43_003184	COG0484	heat shock protein binding
FOA43_003194	COG0833	amino acid
FOA43_003199	COG2814	Major facilitator Superfamily
FOA43_003225	COG2814	Major facilitator Superfamily
FOA43_003230	COG2814	Major facilitator Superfamily
FOA43_003231	COG2814	Major facilitator Superfamily
FOA43_003232	COG3250	beta-galactosidase activity
FOA43_003246	COG0515	serine threonine protein kinase
FOA43_003254	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FOA43_003262	COG2271	Major facilitator Superfamily
FOA43_003266	COG0288	reversible hydration of carbon dioxide
FOA43_003268	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FOA43_003285	COG0724	RNA recognition motif
FOA43_003296	COG2814	Major facilitator Superfamily
FOA43_003298	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FOA43_003314	COG0589	response to stress
FOA43_003315	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FOA43_003320	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FOA43_003321	COG0017	Asparaginyl-tRNA synthetase
FOA43_003324	COG0095	Lipoate-protein ligase
FOA43_003333	COG3830	Belongs to the UPF0237 family
FOA43_003333	COG0560	Phosphoserine phosphatase
FOA43_003340	COG0626	cystathionine gamma-synthase activity
FOA43_003341	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FOA43_003343	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FOA43_003350	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FOA43_003351	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FOA43_003355	COG0443	Heat shock 70 kDa protein
FOA43_003358	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FOA43_003360	COG0833	amino acid
FOA43_003363	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FOA43_003374	COG1073	alpha beta
FOA43_003376	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FOA43_003390	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FOA43_003401	COG0459	protein refolding
FOA43_003408	COG0666	response to abiotic stimulus
FOA43_003418	COG1022	Amp-dependent synthetase and ligase
FOA43_003419	COG0406	alpha-ribazole phosphatase activity
FOA43_003428	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FOA43_003433	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FOA43_003443	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FOA43_003448	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FOA43_003481	COG0443	Heat shock 70 kDa protein
FOA43_003484	COG0515	serine threonine protein kinase
FOA43_003484	COG2815	serine threonine protein kinase
FOA43_003489	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
FOA43_003497	COG0534	Mate efflux family protein
FOA43_003498	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FOA43_003507	COG0024	Methionine aminopeptidase
FOA43_003518	COG0531	amino acid
FOA43_003519	COG1132	(ABC) transporter
FOA43_003520	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FOA43_003526	COG0133	tryptophan synthase activity
FOA43_003529	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FOA43_003540	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FOA43_003546	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FOA43_003560	COG1716	ATPase activity
FOA43_003560	COG0842	Transport permease protein
FOA43_003560	COG1131	(ABC) transporter
FOA43_003564	COG1028	Short-chain dehydrogenase reductase Sdr
FOA43_003572	COG2391	methyltransferase activity
FOA43_003577	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FOA43_003578	COG0505	Belongs to the CarA family
FOA43_003601	COG0626	cystathionine gamma-synthase activity
FOA43_003604	COG0154	amidase activity
FOA43_003617	COG0572	uridine kinase
FOA43_003618	COG1444	tRNA N-acetyltransferase activity
FOA43_003620	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FOA43_003637	COG1132	(ABC) transporter
FOA43_003640	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FOA43_003644	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FOA43_003647	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FOA43_003656	COG1643	Atp-dependent helicase
FOA43_003660	COG0459	protein refolding
FOA43_003669	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FOA43_003671	COG3961	Belongs to the TPP enzyme family
FOA43_003672	COG1063	alcohol dehydrogenase
FOA43_003682	COG0513	Belongs to the DEAD box helicase family
FOA43_003685	COG0222	ribosome binding
FOA43_003686	COG0515	serine threonine protein kinase
FOA43_003686	COG2815	serine threonine protein kinase
FOA43_003689	COG1028	Short-chain dehydrogenase reductase Sdr
FOA43_003692	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FOA43_003700	COG0531	amino acid
FOA43_003710	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FOA43_003715	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FOA43_003725	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FOA43_003732	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FOA43_003732	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FOA43_003734	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FOA43_003737	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FOA43_003762	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FOA43_003767	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FOA43_003770	COG1546	Belongs to the CinA family
FOA43_003770	COG1058	Belongs to the CinA family
FOA43_003773	COG0418	dihydroorotase activity
FOA43_003778	COG1028	Short-chain dehydrogenase reductase Sdr
FOA43_003790	COG1012	belongs to the aldehyde dehydrogenase family
FOA43_003801	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FOA43_003809	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FOA43_003811	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FOA43_003831	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FOA43_003833	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FOA43_003838	COG1643	Atp-dependent helicase
FOA43_003842	COG0183	Belongs to the thiolase family
FOA43_003843	COG0123	including yeast histone deacetylase and acetoin utilization protein
FOA43_003856	COG1196	nuclear chromosome segregation
FOA43_003867	COG0025	NhaP-type Na H and K H
FOA43_003868	COG0194	GDP metabolic process
FOA43_003877	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FOA43_003878	COG0281	malic enzyme
FOA43_003883	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FOA43_003890	COG0736	holo-[acyl-carrier-protein] synthase activity
FOA43_003896	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FOA43_003907	COG0076	glutamate decarboxylase activity
FOA43_003908	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FOA43_003924	COG0443	Heat shock 70 kDa protein
FOA43_003930	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FOA43_003944	COG0477	Major facilitator Superfamily
FOA43_003945	COG2815	serine threonine protein kinase
FOA43_003945	COG0515	serine threonine protein kinase
FOA43_003947	COG0564	pseudouridine synthase activity
FOA43_003949	COG2198	Histidine kinase
FOA43_003949	COG0784	Response regulator, receiver
FOA43_003949	COG5002	protein histidine kinase activity
FOA43_003955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FOA43_003961	COG1741	Belongs to the pirin family
FOA43_003973	COG0339	signal peptide processing
FOA43_003977	COG2226	methyltransferase
FOA43_003978	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FOA43_004003	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FOA43_004004	COG1965	Belongs to the frataxin family
FOA43_004005	COG0488	(ABC) transporter
FOA43_004015	COG0542	response to heat
FOA43_004020	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOA43_004030	COG2815	serine threonine protein kinase
FOA43_004030	COG0515	serine threonine protein kinase
FOA43_004038	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FOA43_004039	COG0366	Alpha amylase catalytic
FOA43_004042	COG0405	Gamma-glutamyltransferase
FOA43_004052	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FOA43_004057	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOA43_004058	COG0435	Glutathione S-transferase
FOA43_004059	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FOA43_004062	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FOA43_004065	COG0724	RNA recognition motif
FOA43_004067	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FOA43_004071	COG0656	L-ascorbic acid biosynthetic process
FOA43_004081	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FOA43_004086	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FOA43_004092	COG2815	serine threonine protein kinase
FOA43_004092	COG0515	serine threonine protein kinase
FOA43_004095	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FOA43_004098	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FOA43_004103	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FOA43_004104	COG0450	alkyl hydroperoxide reductase
FOA43_004115	COG0417	DNA replication proofreading
FOA43_004129	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FOA43_004129	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FOA43_004130	COG0473	3-isopropylmalate dehydrogenase activity
FOA43_004142	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FOA43_004145	COG3474	cytochrome
FOA43_004153	COG1132	(ABC) transporter
FOA43_004155	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FOA43_004156	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FOA43_004158	COG1335	isochorismatase
FOA43_004174	COG0440	acetolactate synthase activity
FOA43_004177	COG0142	geranyltranstransferase activity
FOA43_004180	COG0513	Belongs to the DEAD box helicase family
FOA43_004181	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FOA43_004182	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FOA43_004186	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FOA43_004189	COG0724	RNA recognition motif
FOA43_004216	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FOA43_004217	COG0513	Belongs to the DEAD box helicase family
FOA43_004219	COG2040	homocysteine
FOA43_004229	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FOA43_004246	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FOA43_004248	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FOA43_004249	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FOA43_004250	COG1119	ATPase activity
FOA43_004251	COG0156	8-amino-7-oxononanoate synthase activity
FOA43_004253	COG0656	L-ascorbic acid biosynthetic process
FOA43_004256	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FOA43_004259	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FOA43_004280	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FOA43_004282	COG0724	RNA recognition motif
FOA43_004285	COG1902	pentaerythritol trinitrate reductase activity
FOA43_004286	COG1902	pentaerythritol trinitrate reductase activity
FOA43_004287	COG1902	pentaerythritol trinitrate reductase activity
FOA43_004329	COG0442	prolyl-tRNA aminoacylation
FOA43_004343	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FOA43_004368	COG1012	belongs to the aldehyde dehydrogenase family
FOA43_004375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FOA43_004386	COG0157	Belongs to the NadC ModD family
FOA43_004398	COG0148	phosphopyruvate hydratase activity
FOA43_004405	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FOA43_004406	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FOA43_004422	COG1034	ATP synthesis coupled electron transport
FOA43_004427	COG0259	pyridoxamine-phosphate oxidase activity
FOA43_004428	COG0655	NAD(P)H dehydrogenase (quinone) activity
FOA43_004429	COG0655	NAD(P)H dehydrogenase (quinone) activity
FOA43_004438	COG0477	Major facilitator Superfamily
FOA43_004439	COG2217	Heavy metal translocating P-type atpase
FOA43_004450	COG0277	FAD linked oxidase domain protein
FOA43_004463	COG2267	carboxylic ester hydrolase activity
FOA43_004468	COG1716	ATPase activity
FOA43_004468	COG1131	(ABC) transporter
FOA43_004468	COG0842	Transport permease protein
FOA43_004472	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FOA43_004473	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FOA43_004479	COG0047	phosphoribosylformylglycinamidine synthase activity
FOA43_004479	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FOA43_004482	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FOA43_004483	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FOA43_004487	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FOA43_004499	COG0156	8-amino-7-oxononanoate synthase activity
FOA43_004503	COG2205	protein histidine kinase activity
FOA43_004503	COG4999	Histidine kinase
FOA43_004503	COG3437	response regulator, receiver
FOA43_004503	COG3850	Histidine kinase
FOA43_004504	COG0538	isocitrate dehydrogenase activity
FOA43_004509	COG0527	aspartate kinase activity
FOA43_004515	COG2815	serine threonine protein kinase
FOA43_004515	COG0515	serine threonine protein kinase
FOA43_004518	COG1196	nuclear chromosome segregation
FOA43_004525	COG2814	Major facilitator Superfamily
FOA43_004528	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FOA43_004531	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FOA43_004535	COG0175	sulfate reduction
FOA43_004538	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FOA43_004544	COG0563	adenylate kinase activity
FOA43_004546	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FOA43_004550	COG1657	PFAM Prenyltransferase squalene oxidase
FOA43_004565	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FOA43_004576	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FOA43_004578	COG4178	(ABC) transporter
FOA43_004579	COG0248	Ppx GppA phosphatase
FOA43_004586	COG0515	serine threonine protein kinase
FOA43_004586	COG2815	serine threonine protein kinase
FOA43_004587	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FOA43_004593	COG0475	glutathione-regulated potassium exporter activity
FOA43_004600	COG0688	phosphatidylethanolamine metabolic process
FOA43_004605	COG2815	serine threonine protein kinase
FOA43_004605	COG0515	serine threonine protein kinase
FOA43_004608	COG1404	Belongs to the peptidase S8 family
FOA43_004609	COG3579	cysteine-type endopeptidase activity
FOA43_004611	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FOA43_004611	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FOA43_004622	COG1183	phosphatidylcholine synthase activity
FOA43_004623	COG1448	Aminotransferase
FOA43_004625	COG1196	nuclear chromosome segregation
FOA43_004629	COG0477	Major facilitator Superfamily
FOA43_004629	COG2814	Major facilitator Superfamily
FOA43_004635	COG0277	FAD linked oxidase domain protein
FOA43_004641	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FOA43_004646	COG1819	glycosyl
FOA43_004647	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FOA43_004671	COG0484	heat shock protein binding
FOA43_004676	COG0113	porphobilinogen synthase activity
FOA43_004678	COG0724	RNA recognition motif
FOA43_004688	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FOA43_004691	COG0504	CTP synthase activity
FOA43_004724	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FOA43_004727	COG0484	heat shock protein binding
FOA43_004735	COG0833	amino acid
FOA43_004742	COG1222	aaa ATPase
FOA43_004744	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FOA43_004747	COG0563	adenylate kinase activity
FOA43_004757	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FOA43_004759	COG0484	heat shock protein binding
FOA43_004761	COG0588	phosphoglycerate mutase activity
FOA43_004772	COG0515	serine threonine protein kinase
FOA43_004775	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FOA43_004777	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FOA43_004806	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FOA43_004806	COG1648	precorrin-2 dehydrogenase activity
FOA43_004812	COG1025	Belongs to the peptidase M16 family
FOA43_004812	COG1025	Belongs to the peptidase M16 family
FOA43_004816	COG0833	amino acid
FOA43_004819	COG1028	Short-chain dehydrogenase reductase Sdr
FOA43_004824	COG1228	amidohydrolase