locus-tag	class	description
A616_RS00010	COG0592	DNA-directed DNA polymerase activity
A616_RS00015	COG2501	S4 domain
A616_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A616_RS00030	COG0187	DNA topoisomerase II activity
A616_RS00170	COG3850	Histidine kinase
A616_RS00170	COG5002	protein histidine kinase activity
A616_RS00175	COG0745	RESPONSE REGULATOR receiver
A616_RS00180	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A616_RS00210	COG0516	GMP reductase activity
A616_RS00210	COG0517	IMP dehydrogenase activity
A616_RS00220	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
A616_RS00225	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A616_RS00230	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A616_RS00240	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A616_RS00245	COG2224	Isocitrate lyase
A616_RS00265	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A616_RS00270	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A616_RS00275	COG1349	DNA-binding transcription factor activity
A616_RS00280	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A616_RS00320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A616_RS00335	COG2259	Doxx family
A616_RS00340	COG1733	regulation of RNA biosynthetic process
A616_RS00360	COG1263	PTS System
A616_RS00360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A616_RS00360	COG2190	(PTS) system
A616_RS00375	COG2190	(PTS) system
A616_RS00380	COG3711	transcriptional antiterminator
A616_RS00390	COG0590	tRNA wobble adenosine to inosine editing
A616_RS00395	COG1187	pseudouridine synthase activity
A616_RS00405	COG2814	Major facilitator Superfamily
A616_RS00410	COG0640	Transcriptional regulator
A616_RS00435	COG0425	Belongs to the sulfur carrier protein TusA family
A616_RS00435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A616_RS00440	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A616_RS00440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A616_RS00445	COG0425	Belongs to the sulfur carrier protein TusA family
A616_RS00450	COG0730	response to heat
A616_RS00455	COG2210	Belongs to the sulfur carrier protein TusA family
A616_RS00460	COG1937	Protein conserved in bacteria
A616_RS00470	COG2910	NAD(P)H-binding
A616_RS00485	COG0586	Pfam SNARE associated Golgi protein
A616_RS00495	COG2199	diguanylate cyclase activity
A616_RS00495	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A616_RS00505	COG3852	Histidine kinase
A616_RS00510	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A616_RS00515	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A616_RS00520	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A616_RS00560	COG1982	Orn Lys Arg decarboxylase major
A616_RS00565	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A616_RS00570	COG3870	Protein conserved in bacteria
A616_RS00575	COG1728	Protein conserved in bacteria
A616_RS00580	COG0470	DNA polymerase III
A616_RS00585	COG1774	PSP1 C-terminal conserved region
A616_RS00590	COG4467	Involved in initiation control of chromosome replication
A616_RS00595	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A616_RS00605	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A616_RS00610	COG2226	methyltransferase
A616_RS00615	COG2002	toxin-antitoxin pair type II binding
A616_RS00620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A616_RS00620	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A616_RS00625	COG0084	hydrolase, TatD family'
A616_RS00630	COG1388	LysM domain
A616_RS00630	COG3584	3D domain protein
A616_RS00640	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A616_RS00645	COG4466	Protein conserved in bacteria
A616_RS00655	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A616_RS00660	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A616_RS00665	COG0251	oxidation-reduction process
A616_RS00670	COG2088	sporulation resulting in formation of a cellular spore
A616_RS00675	COG0523	cobalamin synthesis protein
A616_RS00680	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A616_RS00685	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A616_RS00690	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A616_RS00695	COG0193	aminoacyl-tRNA hydrolase activity
A616_RS00705	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A616_RS00710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A616_RS00715	COG2002	toxin-antitoxin pair type II binding
A616_RS00720	COG2244	polysaccharide biosynthetic process
A616_RS00725	COG3956	TIGRFAM MazG family protein
A616_RS00730	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A616_RS00760	COG1098	S1 RNA binding domain
A616_RS00765	COG2208	phosphoserine phosphatase activity
A616_RS00770	COG2304	oxidoreductase activity
A616_RS00775	COG0515	serine threonine protein kinase
A616_RS00785	COG3610	response to peptide
A616_RS00795	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A616_RS00800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A616_RS00805	COG0561	phosphatase activity
A616_RS00815	COG2819	hydrolase of the alpha beta superfamily
A616_RS00820	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A616_RS00825	COG0772	Belongs to the SEDS family
A616_RS00830	COG1695	Transcriptional regulator
A616_RS00840	COG3443	Belongs to the bacterial solute-binding protein 9 family
A616_RS00840	COG0803	Belongs to the bacterial solute-binding protein 9 family
A616_RS00845	COG1121	(ABC) transporter
A616_RS00850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A616_RS00855	COG0735	belongs to the Fur family
A616_RS00860	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A616_RS00870	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A616_RS00950	COG2894	cell division
A616_RS01060	COG0601	transmembrane transport
A616_RS01065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A616_RS01070	COG0444	Belongs to the ABC transporter superfamily
A616_RS01075	COG4166	transmembrane transport
A616_RS01080	COG4948	Mandelate Racemase Muconate Lactonizing
A616_RS01085	COG0791	NLP P60 protein
A616_RS01090	COG4608	Belongs to the ABC transporter superfamily
A616_RS01095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A616_RS01100	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A616_RS01105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A616_RS01110	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A616_RS01115	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A616_RS01120	COG0512	Glutamine amidotransferase of anthranilate synthase
A616_RS01130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A616_RS01135	COG0805	protein transport
A616_RS01140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A616_RS01145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A616_RS01150	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A616_RS01155	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A616_RS01160	COG1396	sequence-specific DNA binding
A616_RS01165	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A616_RS01170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A616_RS01210	COG0546	phosphoglycolate phosphatase activity
A616_RS01220	COG3880	PFAM UvrB UvrC protein
A616_RS01225	COG3869	Catalyzes the specific phosphorylation of arginine residues in
A616_RS01230	COG0542	response to heat
A616_RS01235	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A616_RS01240	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
A616_RS01245	COG1183	phosphatidylcholine synthase activity
A616_RS01255	COG4956	integral membrane protein (PIN domain superfamily)
A616_RS01260	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A616_RS01265	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A616_RS01270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A616_RS01275	COG1045	serine acetyltransferase
A616_RS01280	COG0215	cysteine-tRNA ligase activity
A616_RS01285	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A616_RS01290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A616_RS01295	COG3688	RNA-binding protein containing a PIN domain
A616_RS01305	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A616_RS01315	COG0250	Participates in transcription elongation, termination and antitermination
A616_RS01320	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A616_RS01325	COG0081	regulation of translation
A616_RS01335	COG0222	ribosome binding
A616_RS01340	COG2813	Specifically methylates the guanine in position
A616_RS01345	COG0085	RNA polymerase activity
A616_RS01350	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A616_RS01355	COG1358	cellular component organization or biogenesis
A616_RS01360	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A616_RS01365	COG0049	tRNA binding
A616_RS01370	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A616_RS01375	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A616_RS01380	COG0697	spore germination
A616_RS01385	COG2346	COG2346, Truncated hemoglobins
A616_RS01395	COG0051	transcription antitermination factor activity, RNA binding
A616_RS01400	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A616_RS01405	COG0088	Forms part of the polypeptide exit tunnel
A616_RS01410	COG0089	rRNA binding
A616_RS01415	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A616_RS01420	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A616_RS01425	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A616_RS01430	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A616_RS01435	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A616_RS01440	COG0255	Belongs to the universal ribosomal protein uL29 family
A616_RS01445	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A616_RS01450	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A616_RS01455	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A616_RS01460	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A616_RS01465	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A616_RS01470	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A616_RS01475	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A616_RS01480	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A616_RS01485	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A616_RS01490	COG1841	ribosomal large subunit assembly
A616_RS01495	COG0200	Binds to the 23S rRNA
A616_RS01500	COG0201	protein transport
A616_RS01505	COG0563	adenylate kinase activity
A616_RS01510	COG0024	Methionine aminopeptidase
A616_RS01515	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A616_RS01520	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A616_RS01525	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A616_RS01530	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A616_RS01535	COG0202	RNA polymerase activity
A616_RS01540	COG0203	ribosomal protein L17
A616_RS01545	COG1122	ATPase activity
A616_RS01550	COG1122	ATPase activity
A616_RS01555	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A616_RS01560	COG0101	tRNA pseudouridine synthase activity
A616_RS01565	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A616_RS01570	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A616_RS01575	COG0860	N-Acetylmuramoyl-L-alanine amidase
A616_RS01580	COG0489	protein tyrosine kinase activity
A616_RS01590	COG2194	sulfuric ester hydrolase activity
A616_RS01595	COG0726	polysaccharide deacetylase
A616_RS01685	COG0010	Belongs to the arginase family
A616_RS01695	COG1595	DNA-templated transcription, initiation
A616_RS01700	COG5662	AntiSigma factor
A616_RS01705	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A616_RS01715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A616_RS01720	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A616_RS01735	COG5577	PFAM Coat F domain
A616_RS01740	COG1063	alcohol dehydrogenase
A616_RS01750	COG5577	PFAM Coat F domain
A616_RS01765	COG0577	efflux transmembrane transporter activity
A616_RS01765	COG1136	(ABC) transporter
A616_RS01775	COG2271	Major facilitator Superfamily
A616_RS01790	COG1132	(ABC) transporter
A616_RS01795	COG0300	oxidoreductase activity
A616_RS01805	COG1309	transcriptional regulator
A616_RS01810	COG2814	Major facilitator Superfamily
A616_RS01820	COG0657	acetylesterase activity
A616_RS01825	COG1113	amino acid transport
A616_RS01830	COG2322	membrane
A616_RS01845	COG3173	Aminoglycoside phosphotransferase
A616_RS01850	COG0708	Exodeoxyribonuclease III
A616_RS01855	COG1253	flavin adenine dinucleotide binding
A616_RS01865	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A616_RS01870	COG0789	Transcriptional regulator
A616_RS01870	COG4978	Transcriptional regulator
A616_RS01890	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A616_RS01895	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A616_RS01900	COG2169	Transcriptional regulator
A616_RS01905	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
A616_RS01915	COG1309	transcriptional regulator
A616_RS01935	COG2814	Major facilitator Superfamily
A616_RS01945	COG2318	DinB family
A616_RS01950	COG0778	Nitroreductase
A616_RS01955	COG0346	lactoylglutathione lyase activity
A616_RS01960	COG0400	carboxylic ester hydrolase activity
A616_RS01970	COG5002	protein histidine kinase activity
A616_RS01970	COG3850	Histidine kinase
A616_RS02015	COG2318	DinB family
A616_RS02030	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A616_RS02030	COG2207	Transcriptional regulator
A616_RS02035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A616_RS02040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A616_RS02045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A616_RS02050	COG2819	hydrolase of the alpha beta superfamily
A616_RS02065	COG3290	protein histidine kinase activity
A616_RS02065	COG3829	transcription factor binding
A616_RS02070	COG2610	gluconate transmembrane transporter activity
A616_RS02075	COG1028	Short-chain dehydrogenase reductase Sdr
A616_RS02095	COG0745	RESPONSE REGULATOR receiver
A616_RS02100	COG5002	protein histidine kinase activity
A616_RS02105	COG4841	protein insertion into membrane
A616_RS02115	COG0860	N-Acetylmuramoyl-L-alanine amidase
A616_RS02125	COG4948	Mandelate Racemase Muconate Lactonizing
A616_RS02130	COG1473	amidohydrolase
A616_RS02140	COG3829	transcription factor binding
A616_RS02140	COG3290	protein histidine kinase activity
A616_RS02150	COG0427	acetyl-CoA hydrolase
A616_RS02155	COG2814	Major facilitator Superfamily
A616_RS02160	COG1522	sequence-specific DNA binding
A616_RS02165	COG1294	oxidase, subunit
A616_RS02170	COG1271	oxidase subunit
A616_RS02175	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A616_RS02180	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A616_RS02185	COG1741	Belongs to the pirin family
A616_RS02190	COG2259	Doxx family
A616_RS02195	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A616_RS02200	COG1846	Transcriptional regulator
A616_RS02205	COG1522	sequence-specific DNA binding
A616_RS02205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A616_RS02210	COG2313	pseudouridylate synthase activity
A616_RS02215	COG2217	Heavy metal translocating P-type atpase
A616_RS02220	COG2608	mercury ion transmembrane transporter activity
A616_RS02230	COG0517	IMP dehydrogenase activity
A616_RS02230	COG4175	Glycine betaine
A616_RS02255	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A616_RS02260	COG0840	transmembrane signaling receptor activity
A616_RS02260	COG3290	protein histidine kinase activity
A616_RS02265	COG5001	Diguanylate cyclase
A616_RS02265	COG3300	MHYT domain
A616_RS02275	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A616_RS02280	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A616_RS02290	COG2205	protein histidine kinase activity
A616_RS02310	COG1595	DNA-templated transcription, initiation
A616_RS02320	COG1595	DNA-templated transcription, initiation
A616_RS02335	COG3226	Transcriptional regulator
A616_RS02340	COG1971	Probably functions as a manganese efflux pump
A616_RS02345	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A616_RS02365	COG4585	Histidine kinase
A616_RS02370	COG2197	response regulator
A616_RS02380	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A616_RS02385	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A616_RS02390	COG1028	Short-chain dehydrogenase reductase Sdr
A616_RS02395	COG0778	Nitroreductase
A616_RS02400	COG5002	protein histidine kinase activity
A616_RS02405	COG0745	RESPONSE REGULATOR receiver
A616_RS02420	COG0523	cobalamin synthesis protein
A616_RS02430	COG0438	transferase activity, transferring glycosyl groups
A616_RS02440	COG0438	transferase activity, transferring glycosyl groups
A616_RS02445	COG1929	Belongs to the glycerate kinase type-1 family
A616_RS02450	COG0475	glutathione-regulated potassium exporter activity
A616_RS02465	COG1522	sequence-specific DNA binding
A616_RS02470	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A616_RS02485	COG0740	serine-type endopeptidase activity
A616_RS02495	COG5278	phosphoserine phosphatase activity
A616_RS02495	COG0840	transmembrane signaling receptor activity
A616_RS02520	COG0583	DNA-binding transcription factor activity
A616_RS02525	COG2311	Membrane
A616_RS02530	COG0372	Belongs to the citrate synthase family
A616_RS02535	COG1902	pentaerythritol trinitrate reductase activity
A616_RS02550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A616_RS02570	COG4555	ABC transporter
A616_RS02595	COG0714	Associated with various cellular activities
A616_RS02615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A616_RS02620	COG1999	signal sequence binding
A616_RS02635	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A616_RS02645	COG1028	Short-chain dehydrogenase reductase Sdr
A616_RS02655	COG1595	DNA-templated transcription, initiation
A616_RS02665	COG2814	Major facilitator Superfamily
A616_RS02670	COG1316	TRANSCRIPTIONal
A616_RS02690	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A616_RS02705	COG4166	transmembrane transport
A616_RS02720	COG4166	transmembrane transport
A616_RS02725	COG4166	transmembrane transport
A616_RS02730	COG4166	transmembrane transport
A616_RS02745	COG2247	cell wall binding repeat
A616_RS02745	COG0860	N-Acetylmuramoyl-L-alanine amidase
A616_RS02760	COG2155	Conserved Protein
A616_RS02765	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A616_RS02770	COG0573	inorganic phosphate transmembrane transporter activity
A616_RS02775	COG0581	inorganic phosphate transmembrane transporter activity
A616_RS02780	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A616_RS02790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A616_RS02795	COG1733	regulation of RNA biosynthetic process
A616_RS02805	COG2249	NAD(P)H dehydrogenase (quinone) activity
A616_RS02810	COG1028	Short-chain dehydrogenase reductase Sdr
A616_RS02815	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A616_RS02835	COG0640	Transcriptional regulator
A616_RS02850	COG0736	holo-[acyl-carrier-protein] synthase activity
A616_RS02855	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A616_RS02880	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A616_RS02885	COG0864	Transcriptional regulator
A616_RS02890	COG2337	Toxic component of a toxin-antitoxin (TA) module
A616_RS02895	COG2172	sigma factor antagonist activity
A616_RS02900	COG2208	phosphoserine phosphatase activity
A616_RS02905	COG1366	Belongs to the anti-sigma-factor antagonist family
A616_RS02910	COG2172	sigma factor antagonist activity
A616_RS02915	COG1191	sigma factor activity
A616_RS02920	COG2183	response to ionizing radiation
A616_RS02935	COG3091	SprT-like family
A616_RS02940	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A616_RS02945	COG0802	atpase or kinase
A616_RS02950	COG1214	PFAM Peptidase M22, glycoprotease
A616_RS02955	COG0456	acetyltransferase
A616_RS02970	COG1595	DNA-templated transcription, initiation
A616_RS02980	COG0488	(ABC) transporter
A616_RS02985	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A616_RS02990	COG0521	Mo-molybdopterin cofactor biosynthetic process
A616_RS03000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A616_RS03005	COG0805	protein transport
A616_RS03015	COG2340	Cysteine-rich secretory protein family
A616_RS03020	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A616_RS03030	COG0546	phosphoglycolate phosphatase activity
A616_RS03160	COG0714	Associated with various cellular activities
A616_RS03170	COG1305	Transglutaminase-like
A616_RS03185	COG2252	PERMEase
A616_RS03205	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A616_RS03210	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A616_RS03215	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A616_RS03225	COG1595	DNA-templated transcription, initiation
A616_RS03235	COG0745	RESPONSE REGULATOR receiver
A616_RS03240	COG2205	protein histidine kinase activity
A616_RS03245	COG1136	(ABC) transporter
A616_RS03250	COG0577	efflux transmembrane transporter activity
A616_RS03255	COG0590	tRNA wobble adenosine to inosine editing
A616_RS03265	COG0747	negative chemotaxis
A616_RS03275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A616_RS03280	COG0444	Belongs to the ABC transporter superfamily
A616_RS03285	COG4608	Belongs to the ABC transporter superfamily
A616_RS03290	COG2059	Chromate
A616_RS03295	COG2059	Chromate
A616_RS03305	COG0405	Gamma-glutamyltransferase
A616_RS03340	COG2201	protein-glutamate methylesterase activity
A616_RS03345	COG2201	protein-glutamate methylesterase activity
A616_RS03350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A616_RS03395	COG3279	Response regulator of the LytR AlgR family
A616_RS03400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A616_RS03405	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A616_RS03425	COG1459	type II secretion system
A616_RS03440	COG2304	oxidoreductase activity
A616_RS03480	COG2304	oxidoreductase activity
A616_RS03500	COG2378	regulation of single-species biofilm formation
A616_RS03510	COG1181	Belongs to the D-alanine--D-alanine ligase family
A616_RS03515	COG1876	peptidase activity
A616_RS03540	COG1979	alcohol dehydrogenase
A616_RS03545	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A616_RS03550	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A616_RS03555	COG0047	phosphoribosylformylglycinamidine synthase activity
A616_RS03560	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A616_RS03565	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A616_RS03570	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A616_RS03575	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A616_RS03585	COG3300	MHYT domain
A616_RS03585	COG5001	Diguanylate cyclase
A616_RS03600	COG0151	Belongs to the GarS family
A616_RS03615	COG2814	Major facilitator Superfamily
A616_RS03630	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A616_RS03640	COG0559	Belongs to the binding-protein-dependent transport system permease family
A616_RS03660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A616_RS03680	COG3842	ATPase activity
A616_RS03685	COG1176	ABC-type spermidine putrescine transport system, permease component I
A616_RS03690	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A616_RS03695	COG2195	Cleaves the N-terminal amino acid of tripeptides
A616_RS03730	COG3507	Belongs to the glycosyl hydrolase 43 family
A616_RS03840	COG1191	sigma factor activity
A616_RS03845	COG0667	Aldo Keto reductase
A616_RS03850	COG0697	spore germination
A616_RS03870	COG0516	GMP reductase activity
A616_RS03870	COG0517	IMP dehydrogenase activity
A616_RS03880	COG2205	protein histidine kinase activity
A616_RS03880	COG2770	Histidine kinase
A616_RS03885	COG0745	RESPONSE REGULATOR receiver
A616_RS03890	COG1470	cell adhesion involved in biofilm formation
A616_RS03895	COG4496	protein, YerC YecD
A616_RS03900	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
A616_RS03915	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A616_RS03930	COG4753	response regulator
A616_RS03930	COG2207	Transcriptional regulator
A616_RS03935	COG2972	Histidine kinase
A616_RS03955	COG4211	Belongs to the binding-protein-dependent transport system permease family
A616_RS03965	COG2720	vancomycin resistance protein
A616_RS03970	COG0210	DNA helicase
A616_RS03975	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A616_RS03990	COG1012	belongs to the aldehyde dehydrogenase family
A616_RS03995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A616_RS04005	COG0688	phosphatidylethanolamine metabolic process
A616_RS04015	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A616_RS04020	COG0154	amidase activity
A616_RS04025	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A616_RS04040	COG1595	DNA-templated transcription, initiation
A616_RS04055	COG4555	ABC transporter
A616_RS04060	COG1668	transmembrane transport
A616_RS04065	COG0697	spore germination
A616_RS04070	COG1940	carbohydrate kinase activity
A616_RS04075	COG1597	lipid kinase activity
A616_RS04080	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A616_RS04085	COG0582	viral genome integration into host DNA
A616_RS04205	COG4282	regulation of fungal-type cell wall biogenesis
A616_RS04255	COG2801	Transposase and inactivated derivatives
A616_RS04285	COG3773	Cell wall hydrolase
A616_RS04300	COG1442	glycosyl transferase family 8
A616_RS04305	COG1819	glycosyl
A616_RS04330	COG0133	tryptophan synthase activity
A616_RS04340	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A616_RS04370	COG2814	Major facilitator Superfamily
A616_RS04375	COG1309	transcriptional regulator
A616_RS04395	COG1131	(ABC) transporter
A616_RS04400	COG0842	Transport permease protein
A616_RS04400	COG1511	domain protein
A616_RS04410	COG2972	Histidine kinase
A616_RS04410	COG0745	RESPONSE REGULATOR receiver
A616_RS04420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A616_RS04430	COG1595	DNA-templated transcription, initiation
A616_RS04440	COG1086	Polysaccharide biosynthesis protein
A616_RS04445	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A616_RS04450	COG0745	RESPONSE REGULATOR receiver
A616_RS04455	COG5002	protein histidine kinase activity
A616_RS04465	COG0477	Major facilitator Superfamily
A616_RS04475	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A616_RS04485	COG2197	response regulator
A616_RS04490	COG4585	Histidine kinase
A616_RS04510	COG0726	polysaccharide deacetylase
A616_RS04520	COG1136	(ABC) transporter
A616_RS04550	COG4977	sequence-specific DNA binding
A616_RS04555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A616_RS04560	COG3239	Fatty acid desaturase
A616_RS04565	COG4585	Histidine kinase
A616_RS04570	COG2197	response regulator
A616_RS04575	COG0640	Transcriptional regulator
A616_RS04580	COG0346	lactoylglutathione lyase activity
A616_RS04585	COG0798	PFAM Bile acid sodium symporter
A616_RS04590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A616_RS04615	COG0673	inositol 2-dehydrogenase activity
A616_RS04620	COG0747	negative chemotaxis
A616_RS04625	COG0601	transmembrane transport
A616_RS04635	COG0444	Belongs to the ABC transporter superfamily
A616_RS04640	COG4608	Belongs to the ABC transporter superfamily
A616_RS04645	COG1940	carbohydrate kinase activity
A616_RS04655	COG0673	inositol 2-dehydrogenase activity
A616_RS04665	COG3152	Membrane
A616_RS04670	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A616_RS04685	COG0666	response to abiotic stimulus
A616_RS04695	COG0745	RESPONSE REGULATOR receiver
A616_RS04700	COG5002	protein histidine kinase activity
A616_RS04705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A616_RS04710	COG2261	transglycosylase associated protein
A616_RS04720	COG1823	symporter activity
A616_RS04730	COG4166	transmembrane transport
A616_RS04745	COG0702	epimerase
A616_RS04765	COG1473	amidohydrolase
A616_RS04785	COG1609	Transcriptional regulator
A616_RS04790	COG3708	Transcriptional regulator
A616_RS04790	COG2207	Transcriptional regulator
A616_RS04815	COG1473	amidohydrolase
A616_RS04820	COG1288	antiporter activity
A616_RS04835	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A616_RS04840	COG1132	(ABC) transporter
A616_RS04845	COG1132	(ABC) transporter
A616_RS04865	COG0697	spore germination
A616_RS04870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A616_RS04885	COG1278	Cold shock
A616_RS04890	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A616_RS04895	COG1187	pseudouridine synthase activity
A616_RS04900	COG2258	MOSC domain
A616_RS04905	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A616_RS04910	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A616_RS04915	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A616_RS04940	COG1346	cytolysis
A616_RS04945	COG0697	spore germination
A616_RS04960	COG0840	transmembrane signaling receptor activity
A616_RS04970	COG0666	response to abiotic stimulus
A616_RS04975	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A616_RS04985	COG0242	peptide deformylase activity
A616_RS04995	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A616_RS05000	COG1360	Flagellar Motor Protein
A616_RS05010	COG1733	regulation of RNA biosynthetic process
A616_RS05015	COG2267	carboxylic ester hydrolase activity
A616_RS05020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A616_RS05025	COG2076	Multidrug Resistance protein
A616_RS05030	COG2076	Multidrug Resistance protein
A616_RS05040	COG1253	flavin adenine dinucleotide binding
A616_RS05075	COG0577	efflux transmembrane transporter activity
A616_RS05080	COG1136	(ABC) transporter
A616_RS05090	COG0166	Belongs to the GPI family
A616_RS05100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A616_RS05115	COG0494	nUDIX hydrolase
A616_RS05120	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A616_RS05130	COG0442	prolyl-tRNA aminoacylation
A616_RS05145	COG1247	-acetyltransferase
A616_RS05160	COG0004	ammonium transporteR
A616_RS05185	COG2814	Major facilitator Superfamily
A616_RS05190	COG0640	Transcriptional regulator
A616_RS05195	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A616_RS05210	COG2996	Protein conserved in bacteria
A616_RS05225	COG2358	TRAP transporter, solute receptor (TAXI family
A616_RS05230	COG4191	Histidine kinase
A616_RS05235	COG0784	Response regulator, receiver
A616_RS05255	COG2133	pyrroloquinoline quinone binding
A616_RS05270	COG3829	transcription factor binding
A616_RS05270	COG3290	protein histidine kinase activity
A616_RS05280	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A616_RS05285	COG1114	Component of the transport system for branched-chain amino acids
A616_RS05290	COG0745	RESPONSE REGULATOR receiver
A616_RS05295	COG3850	Histidine kinase
A616_RS05295	COG5002	protein histidine kinase activity
A616_RS05305	COG1619	proteins homologs of microcin C7 resistance protein MccF
A616_RS05310	COG0697	spore germination
A616_RS05325	COG0824	Thioesterase
A616_RS05360	COG0745	RESPONSE REGULATOR receiver
A616_RS05365	COG2205	protein histidine kinase activity
A616_RS05375	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A616_RS05385	COG1742	UPF0060 membrane protein
A616_RS05395	COG3192	ethanolamine utilization protein
A616_RS05410	COG0346	lactoylglutathione lyase activity
A616_RS05420	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A616_RS05425	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
A616_RS05430	COG2032	superoxide dismutase activity
A616_RS05435	COG0745	RESPONSE REGULATOR receiver
A616_RS05440	COG5002	protein histidine kinase activity
A616_RS05445	COG1840	ABC-type Fe3 transport system, periplasmic component
A616_RS05455	COG3842	ATPase activity
A616_RS05460	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A616_RS05475	COG0673	inositol 2-dehydrogenase activity
A616_RS05480	COG2378	regulation of single-species biofilm formation
A616_RS05495	COG0456	acetyltransferase
A616_RS05515	COG2205	protein histidine kinase activity
A616_RS05530	COG0084	hydrolase, TatD family'
A616_RS05545	COG1136	(ABC) transporter
A616_RS05555	COG1378	Sugar-specific transcriptional regulator TrmB
A616_RS05635	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A616_RS05645	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A616_RS05665	COG1268	BioY protein
A616_RS05670	COG2124	cytochrome p450
A616_RS05675	COG5002	protein histidine kinase activity
A616_RS05680	COG0745	RESPONSE REGULATOR receiver
A616_RS05695	COG1842	Phage shock protein A
A616_RS05700	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A616_RS05705	COG4758	membrane
A616_RS05710	COG4585	Histidine kinase
A616_RS05715	COG2197	response regulator
A616_RS05720	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A616_RS05740	COG0583	DNA-binding transcription factor activity
A616_RS05745	COG2814	Major facilitator Superfamily
A616_RS05750	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A616_RS05760	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A616_RS05765	COG3384	dioxygenase
A616_RS05770	COG1595	DNA-templated transcription, initiation
A616_RS05775	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A616_RS05785	COG1988	membrane-bound metal-dependent
A616_RS05800	COG0561	phosphatase activity
A616_RS05810	COG0840	transmembrane signaling receptor activity
A616_RS05820	COG1028	Short-chain dehydrogenase reductase Sdr
A616_RS05825	COG0456	acetyltransferase
A616_RS05830	COG3557	Belongs to the UPF0374 family
A616_RS05835	COG1132	(ABC) transporter
A616_RS05850	COG0655	NAD(P)H dehydrogenase (quinone) activity
A616_RS05915	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A616_RS05920	COG2738	Putative neutral zinc metallopeptidase
A616_RS05925	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A616_RS05935	COG4555	ABC transporter
A616_RS05950	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A616_RS05955	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A616_RS05960	COG0546	phosphoglycolate phosphatase activity
A616_RS05970	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A616_RS05975	COG1363	Peptidase, m42
A616_RS05980	COG2226	methyltransferase
A616_RS05985	COG2096	Adenosyltransferase
A616_RS05995	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A616_RS06000	COG0735	belongs to the Fur family
A616_RS06005	COG3858	chitin binding
A616_RS06100	COG2233	PERMEase
A616_RS06105	COG3382	B3 4 domain protein
A616_RS06110	COG0328	RNA-DNA hybrid ribonuclease activity
A616_RS06115	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A616_RS06120	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A616_RS06140	COG0546	phosphoglycolate phosphatase activity
A616_RS06160	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A616_RS06215	COG5377	YqaJ viral recombinase family
A616_RS06220	COG3723	Recombinational DNA repair protein, rece pathway
A616_RS06235	COG0305	Participates in initiation and elongation during chromosome replication
A616_RS06345	COG5518	Phage portal protein
A616_RS06355	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A616_RS06495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A616_RS06515	COG1793	dna ligase
A616_RS06530	COG2135	peptidase activity
A616_RS06540	COG2718	Belongs to the UPF0229 family
A616_RS06545	COG4682	membrane
A616_RS06550	COG2267	carboxylic ester hydrolase activity
A616_RS06555	COG0840	transmembrane signaling receptor activity
A616_RS06585	COG4912	Dna alkylation repair
A616_RS06590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A616_RS06595	COG0765	amino acid transport
A616_RS06600	COG1126	abc transporter atp-binding protein
A616_RS06610	COG1695	Transcriptional regulator
A616_RS06625	COG0583	DNA-binding transcription factor activity
A616_RS06650	COG5001	Diguanylate cyclase
A616_RS06650	COG3300	MHYT domain
A616_RS06655	COG0697	spore germination
A616_RS06660	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A616_RS06665	COG1335	isochorismatase
A616_RS06680	COG0745	RESPONSE REGULATOR receiver
A616_RS06685	COG5002	protein histidine kinase activity
A616_RS06690	COG1522	sequence-specific DNA binding
A616_RS06695	COG0436	Aminotransferase
A616_RS06720	COG0833	amino acid
A616_RS06760	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A616_RS06790	COG0746	molybdenum cofactor guanylyltransferase activity
A616_RS06800	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A616_RS06805	COG2223	nitrite transmembrane transporter activity
A616_RS06820	COG0303	'Molybdopterin
A616_RS06825	COG1763	Mo-molybdopterin cofactor biosynthetic process
A616_RS06840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A616_RS06850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A616_RS06855	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A616_RS06865	COG1988	membrane-bound metal-dependent
A616_RS06875	COG2814	Major facilitator Superfamily
A616_RS06885	COG2259	Doxx family
A616_RS06890	COG3973	AAA domain
A616_RS06900	COG2363	Small membrane protein
A616_RS06930	COG1401	restriction endodeoxyribonuclease activity
A616_RS06945	COG2719	SpoVR family
A616_RS06950	COG1028	Short-chain dehydrogenase reductase Sdr
A616_RS06955	COG1028	Short-chain dehydrogenase reductase Sdr
A616_RS06960	COG1250	3-hydroxyacyl-CoA dehydrogenase
A616_RS06965	COG0840	transmembrane signaling receptor activity
A616_RS06970	COG0840	transmembrane signaling receptor activity
A616_RS07000	COG0861	Integral membrane protein TerC family
A616_RS07005	COG0583	DNA-binding transcription factor activity
A616_RS07015	COG3181	Tripartite tricarboxylate transporter family receptor
A616_RS07030	COG2226	methyltransferase
A616_RS07035	COG1522	sequence-specific DNA binding
A616_RS07040	COG0697	spore germination
A616_RS07045	COG4565	transcriptional regulatory protein
A616_RS07050	COG3290	protein histidine kinase activity
A616_RS07065	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A616_RS07070	COG1845	cytochrome c oxidase, subunit III
A616_RS07115	COG2367	Beta-lactamase
A616_RS07135	COG2814	Major facilitator Superfamily
A616_RS07145	COG2814	Major facilitator Superfamily
A616_RS07170	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
A616_RS07180	COG1595	DNA-templated transcription, initiation
A616_RS07195	COG0765	amino acid transport
A616_RS07200	COG0765	amino acid transport
A616_RS07205	COG4191	Histidine kinase
A616_RS07210	COG0784	Response regulator, receiver
A616_RS07240	COG0069	glutamate synthase activity
A616_RS07245	COG0450	alkyl hydroperoxide reductase
A616_RS07270	COG2707	UPF0756 membrane protein
A616_RS07280	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A616_RS07290	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
A616_RS07295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A616_RS07305	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A616_RS07310	COG0406	alpha-ribazole phosphatase activity
A616_RS07315	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
A616_RS07340	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
A616_RS07370	COG1492	cobalamin metabolic process
A616_RS07375	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A616_RS07380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A616_RS07385	COG1648	precorrin-2 dehydrogenase activity
A616_RS07385	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A616_RS07390	COG0456	acetyltransferase
A616_RS07400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A616_RS07405	COG0475	glutathione-regulated potassium exporter activity
A616_RS07410	COG0490	domain, Protein
A616_RS07420	COG1301	dicarboxylic acid transport
A616_RS07430	COG0745	RESPONSE REGULATOR receiver
A616_RS07435	COG5002	protein histidine kinase activity
A616_RS07440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A616_RS07445	COG3290	protein histidine kinase activity
A616_RS07455	COG3829	transcription factor binding
A616_RS07460	COG1619	proteins homologs of microcin C7 resistance protein MccF
A616_RS07535	COG0783	Belongs to the Dps family
A616_RS07540	COG1072	(Pantothenic acid kinase))
A616_RS07545	COG1683	Conserved Protein
A616_RS07550	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A616_RS07555	COG0583	DNA-binding transcription factor activity
A616_RS07585	COG0596	Alpha beta hydrolase
A616_RS07590	COG0028	Belongs to the TPP enzyme family
A616_RS07600	COG1309	transcriptional regulator
A616_RS07605	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A616_RS07615	COG0180	Tryptophanyl-tRNA synthetase
A616_RS07680	COG0748	coenzyme F420 binding
A616_RS07685	COG1120	ATPase activity
A616_RS07690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A616_RS07710	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A616_RS07725	COG0402	S-adenosylhomocysteine deaminase activity
A616_RS07730	COG1737	Transcriptional regulator
A616_RS07735	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A616_RS07740	COG2182	Extracellular solute-binding protein
A616_RS07750	COG0395	ABC-type sugar transport system, permease component
A616_RS07755	COG2971	BadF BadG BcrA BcrD
A616_RS07760	COG4191	Histidine kinase
A616_RS07770	COG3706	GGDEF domain
A616_RS07775	COG1757	Na H antiporter
A616_RS07785	COG0492	ferredoxin-NADP+ reductase activity
A616_RS07795	COG0450	alkyl hydroperoxide reductase
A616_RS07800	COG0492	ferredoxin-NADP+ reductase activity
A616_RS07815	COG1215	transferase activity, transferring glycosyl groups
A616_RS07820	COG0745	RESPONSE REGULATOR receiver
A616_RS07830	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A616_RS07840	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A616_RS07870	COG0189	ligase activity
A616_RS07875	COG0189	ligase activity
A616_RS07880	COG0189	ligase activity
A616_RS07885	COG0189	ligase activity
A616_RS07890	COG4399	Belongs to the UPF0754 family
A616_RS07895	COG4109	DRTGG domain
A616_RS07905	COG2207	Transcriptional regulator
A616_RS07910	COG0640	Transcriptional regulator
A616_RS07920	COG0587	DNA-directed DNA polymerase activity
A616_RS07925	COG0281	malic enzyme
A616_RS07930	COG2186	Transcriptional regulator
A616_RS07940	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A616_RS07945	COG0825	malonyl-CoA metabolic process
A616_RS07950	COG0205	6-phosphofructokinase activity
A616_RS07965	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A616_RS07975	COG0824	Thioesterase
A616_RS07985	COG0628	permease
A616_RS07990	COG0372	Belongs to the citrate synthase family
A616_RS07995	COG0538	isocitrate dehydrogenase activity
A616_RS08000	COG0039	L-malate dehydrogenase activity
A616_RS08005	COG0745	RESPONSE REGULATOR receiver
A616_RS08010	COG5002	protein histidine kinase activity
A616_RS08015	COG0704	Plays a role in the regulation of phosphate uptake
A616_RS08030	COG2720	vancomycin resistance protein
A616_RS08035	COG1846	Transcriptional regulator
A616_RS08040	COG1566	PFAM secretion protein HlyD family protein
A616_RS08050	COG2814	Major facilitator Superfamily
A616_RS08060	COG0860	N-Acetylmuramoyl-L-alanine amidase
A616_RS08065	COG2861	carbohydrate metabolic process
A616_RS08070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A616_RS08070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A616_RS08075	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A616_RS08080	COG0237	dephospho-CoA kinase activity
A616_RS08090	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A616_RS08100	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A616_RS08110	COG1484	DNA-dependent DNA replication
A616_RS08120	COG4932	domain protein
A616_RS08120	COG5492	domain, Protein
A616_RS08135	COG3279	Response regulator of the LytR AlgR family
A616_RS08140	COG3275	phosphorelay sensor kinase activity
A616_RS08145	COG0477	Major facilitator Superfamily
A616_RS08215	COG2207	Transcriptional regulator
A616_RS08215	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A616_RS08220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A616_RS08225	COG2249	NAD(P)H dehydrogenase (quinone) activity
A616_RS08230	COG4753	response regulator
A616_RS08230	COG2207	Transcriptional regulator
A616_RS08250	COG1846	Transcriptional regulator
A616_RS08255	COG2814	Major facilitator Superfamily
A616_RS08260	COG2814	Major facilitator Superfamily
A616_RS08265	COG1902	pentaerythritol trinitrate reductase activity
A616_RS08270	COG1522	sequence-specific DNA binding
A616_RS08310	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A616_RS08330	COG2909	trisaccharide binding
A616_RS08355	COG1307	EDD domain protein, DegV family
A616_RS08375	COG2311	Membrane
A616_RS08380	COG1361	Conserved repeat domain
A616_RS08380	COG3266	domain, Protein
A616_RS08380	COG2911	Protein conserved in bacteria
A616_RS08390	COG0675	Transposase, IS605 OrfB family
A616_RS08410	COG0577	efflux transmembrane transporter activity
A616_RS08410	COG1136	(ABC) transporter
A616_RS08420	COG0745	RESPONSE REGULATOR receiver
A616_RS08425	COG3850	Histidine kinase
A616_RS08425	COG5002	protein histidine kinase activity
A616_RS08445	COG1129	ABC transporter
A616_RS08455	COG1063	alcohol dehydrogenase
A616_RS08465	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A616_RS08495	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A616_RS08510	COG0326	Molecular chaperone. Has ATPase activity
A616_RS08540	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A616_RS08550	COG1113	amino acid transport
A616_RS08555	COG1121	(ABC) transporter
A616_RS08560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A616_RS08565	COG0803	Belongs to the bacterial solute-binding protein 9 family
A616_RS08570	COG0217	transcriptional regulatory protein
A616_RS08575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A616_RS08580	COG1595	DNA-templated transcription, initiation
A616_RS08600	COG1695	Transcriptional regulator
A616_RS08605	COG0772	Belongs to the SEDS family
A616_RS08620	COG1132	(ABC) transporter
A616_RS08625	COG1132	(ABC) transporter
A616_RS08630	COG2226	methyltransferase
A616_RS08635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A616_RS08655	COG0330	HflC and HflK could
A616_RS08665	COG0450	alkyl hydroperoxide reductase
A616_RS08675	COG3428	Bacterial PH domain
A616_RS08680	COG0346	lactoylglutathione lyase activity
A616_RS08685	COG2323	membrane
A616_RS08690	COG4196	transglutaminase domain protein
A616_RS08700	COG1643	Atp-dependent helicase
A616_RS08715	COG0778	Nitroreductase
A616_RS08720	COG0745	RESPONSE REGULATOR receiver
A616_RS08725	COG5002	protein histidine kinase activity
A616_RS08740	COG1136	(ABC) transporter
A616_RS08745	COG1136	(ABC) transporter
A616_RS08745	COG0577	efflux transmembrane transporter activity
A616_RS08770	COG1970	mechanosensitive ion channel activity
A616_RS08795	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A616_RS08800	COG0747	negative chemotaxis
A616_RS08810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A616_RS08820	COG0444	Belongs to the ABC transporter superfamily
A616_RS08825	COG4608	Belongs to the ABC transporter superfamily
A616_RS08830	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A616_RS08835	COG0277	FAD linked oxidase domain protein
A616_RS08840	COG0247	lactate metabolic process
A616_RS08850	COG2310	stress, protein
A616_RS08875	COG2310	stress, protein
A616_RS08880	COG2310	stress, protein
A616_RS08885	COG2310	stress, protein
A616_RS08890	COG2310	stress, protein
A616_RS08895	COG0861	Integral membrane protein TerC family
A616_RS08905	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A616_RS08935	COG1051	belongs to the nudix hydrolase family
A616_RS08985	COG2814	Major facilitator Superfamily
A616_RS09015	COG1595	DNA-templated transcription, initiation
A616_RS09025	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A616_RS09025	COG2755	lipolytic protein G-D-S-L family
A616_RS09035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A616_RS09045	COG0673	inositol 2-dehydrogenase activity
A616_RS09050	COG1309	transcriptional regulator
A616_RS09060	COG0583	DNA-binding transcription factor activity
A616_RS09075	COG2267	carboxylic ester hydrolase activity
A616_RS09095	COG1012	belongs to the aldehyde dehydrogenase family
A616_RS09130	COG1175	transmembrane transport
A616_RS09135	COG0395	ABC-type sugar transport system, permease component
A616_RS09160	COG4565	transcriptional regulatory protein
A616_RS09165	COG2972	Histidine kinase
A616_RS09170	COG4608	Belongs to the ABC transporter superfamily
A616_RS09175	COG0444	Belongs to the ABC transporter superfamily
A616_RS09180	COG0601	transmembrane transport
A616_RS09185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A616_RS09190	COG0402	S-adenosylhomocysteine deaminase activity
A616_RS09195	COG0402	S-adenosylhomocysteine deaminase activity
A616_RS09200	COG0402	S-adenosylhomocysteine deaminase activity
A616_RS09205	COG1136	(ABC) transporter
A616_RS09210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A616_RS09220	COG1136	(ABC) transporter
A616_RS09225	COG0583	DNA-binding transcription factor activity
A616_RS09230	COG0477	Major facilitator Superfamily
A616_RS09235	COG0583	DNA-binding transcription factor activity
A616_RS09240	COG2814	Major facilitator Superfamily
A616_RS09260	COG1280	lysine exporter protein (LysE YggA)
A616_RS09265	COG2808	Putative FMN-binding domain
A616_RS09270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A616_RS09275	COG0402	S-adenosylhomocysteine deaminase activity
A616_RS09280	COG0402	S-adenosylhomocysteine deaminase activity
A616_RS09285	COG1028	Short-chain dehydrogenase reductase Sdr
A616_RS09290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A616_RS09295	COG2186	Transcriptional regulator
A616_RS09305	COG0747	negative chemotaxis
A616_RS09320	COG0747	negative chemotaxis
A616_RS09325	COG0402	S-adenosylhomocysteine deaminase activity
A616_RS09330	COG0747	negative chemotaxis
A616_RS09335	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A616_RS09340	COG0477	Major facilitator Superfamily
A616_RS09370	COG3773	Cell wall hydrolase
A616_RS09380	COG0318	PFAM AMP-dependent synthetase and ligase
A616_RS09385	COG1960	acyl-CoA dehydrogenase activity
A616_RS09405	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A616_RS09415	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A616_RS09420	COG0840	transmembrane signaling receptor activity
A616_RS09425	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A616_RS09430	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A616_RS09435	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A616_RS09440	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A616_RS09450	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A616_RS09465	COG0175	sulfate reduction
A616_RS09470	COG2046	Belongs to the sulfate adenylyltransferase family
A616_RS09475	COG0028	Belongs to the TPP enzyme family
A616_RS09480	COG0440	acetolactate synthase activity
A616_RS09485	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A616_RS09490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A616_RS09495	COG0473	3-isopropylmalate dehydrogenase activity
A616_RS09500	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A616_RS09505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A616_RS09525	COG0586	Pfam SNARE associated Golgi protein
A616_RS09535	COG3844	kynureninase activity
A616_RS09540	COG0697	spore germination
A616_RS09545	COG0814	amino acid
A616_RS09555	COG0814	amino acid
A616_RS09565	COG0569	domain protein
A616_RS09570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A616_RS09580	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A616_RS09590	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
A616_RS09600	COG1193	negative regulation of DNA recombination
A616_RS09605	COG3766	membrane
A616_RS09610	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A616_RS09615	COG1595	DNA-templated transcription, initiation
A616_RS09625	COG1278	Cold shock
A616_RS09630	COG2362	D-Aminopeptidase
A616_RS09635	COG0438	transferase activity, transferring glycosyl groups
A616_RS09670	COG2244	polysaccharide biosynthetic process
A616_RS09685	COG2264	protein methyltransferase activity
A616_RS09690	COG0183	Belongs to the thiolase family
A616_RS09695	COG1316	TRANSCRIPTIONal
A616_RS09700	COG0318	PFAM AMP-dependent synthetase and ligase
A616_RS09705	COG1309	transcriptional regulator
A616_RS09710	COG1024	Enoyl-CoA hydratase
A616_RS09715	COG2086	electron transfer activity
A616_RS09720	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A616_RS09730	COG3118	belongs to the thioredoxin family
A616_RS09735	COG0683	leucine binding
A616_RS09765	COG0322	excinuclease ABC activity
A616_RS09780	COG2009	succinate dehydrogenase
A616_RS09785	COG1053	succinate dehydrogenase
A616_RS09790	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A616_RS09795	COG1846	Transcriptional regulator
A616_RS09820	COG1132	(ABC) transporter
A616_RS09830	COG0601	transmembrane transport
A616_RS09835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A616_RS09845	COG2197	response regulator
A616_RS09855	COG4942	peptidase
A616_RS09915	COG1175	transmembrane transport
A616_RS09920	COG0395	ABC-type sugar transport system, permease component
A616_RS09925	COG0673	inositol 2-dehydrogenase activity
A616_RS09935	COG0673	inositol 2-dehydrogenase activity
A616_RS09945	COG1940	carbohydrate kinase activity
A616_RS09960	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A616_RS09970	COG1473	amidohydrolase
A616_RS09975	COG3290	protein histidine kinase activity
A616_RS09980	COG2814	Major facilitator Superfamily
A616_RS09985	COG1378	Sugar-specific transcriptional regulator TrmB
A616_RS10000	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A616_RS10035	COG0463	Glycosyl transferase, family 2
A616_RS10045	COG2340	Cysteine-rich secretory protein family
A616_RS10055	COG1216	Glycosyl transferase, family 2
A616_RS10060	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A616_RS10070	COG0662	Cupin 2, conserved barrel domain protein
A616_RS10070	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
A616_RS10080	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A616_RS10105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A616_RS10110	COG1442	glycosyl transferase family 8
A616_RS10110	COG1216	Glycosyl transferase, family 2
A616_RS10130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A616_RS10135	COG0562	UDP-galactopyranose mutase
A616_RS10140	COG0463	Glycosyl transferase, family 2
A616_RS10140	COG1216	Glycosyl transferase, family 2
A616_RS10165	COG4166	transmembrane transport
A616_RS10170	COG3829	transcription factor binding
A616_RS10170	COG3290	protein histidine kinase activity
A616_RS10175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A616_RS10180	COG0601	transmembrane transport
A616_RS10185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A616_RS10190	COG0444	Belongs to the ABC transporter superfamily
A616_RS10195	COG4608	Belongs to the ABC transporter superfamily
A616_RS10205	COG0583	DNA-binding transcription factor activity
A616_RS10210	COG0384	phenazine biosynthesis protein PhzF
A616_RS10230	COG0456	acetyltransferase
A616_RS10240	COG1595	DNA-templated transcription, initiation
A616_RS10255	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A616_RS10260	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A616_RS10275	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A616_RS10280	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A616_RS10285	COG0622	Phosphoesterase
A616_RS10290	COG0544	peptidyl-prolyl cis-trans isomerase activity
A616_RS10295	COG0740	serine-type endopeptidase activity
A616_RS10300	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A616_RS10305	COG0470	DNA polymerase III
A616_RS10305	COG1067	ATP-dependent peptidase activity
A616_RS10315	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A616_RS10320	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A616_RS10330	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A616_RS10335	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A616_RS10340	COG0181	hydroxymethylbilane synthase activity
A616_RS10350	COG0113	porphobilinogen synthase activity
A616_RS10355	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A616_RS10370	COG2267	carboxylic ester hydrolase activity
A616_RS10375	COG0737	Belongs to the 5'-nucleotidase family
A616_RS10380	COG1695	Transcriptional regulator
A616_RS10395	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A616_RS10400	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A616_RS10405	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A616_RS10410	COG1388	LysM domain
A616_RS10445	COG0525	valine-tRNA ligase activity
A616_RS10450	COG0285	dihydrofolate synthase activity
A616_RS10455	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A616_RS10485	COG0424	maF-like protein
A616_RS10490	COG2003	Belongs to the UPF0758 family
A616_RS10495	COG1077	Cell shape determining protein MreB Mrl
A616_RS10500	COG1792	Involved in formation and maintenance of cell shape
A616_RS10505	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A616_RS10510	COG0768	penicillin binding
A616_RS10515	COG0850	regulation of cytokinetic process
A616_RS10520	COG2894	cell division
A616_RS10525	COG0772	Belongs to the SEDS family
A616_RS10530	COG1278	Cold shock
A616_RS10540	COG1994	Peptidase M50
A616_RS10550	COG1530	ribonuclease E activity
A616_RS10555	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A616_RS10565	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A616_RS10575	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A616_RS10590	COG1252	NADH dehydrogenase
A616_RS10595	COG4492	Belongs to the UPF0735 family
A616_RS10600	COG0460	homoserine dehydrogenase
A616_RS10605	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A616_RS10615	COG0077	Prephenate dehydratase
A616_RS10620	COG1388	LysM domain
A616_RS10630	COG0737	Belongs to the 5'-nucleotidase family
A616_RS10650	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A616_RS10655	COG0632	four-way junction helicase activity
A616_RS10660	COG2255	four-way junction helicase activity
A616_RS10670	COG2385	sporulation resulting in formation of a cellular spore
A616_RS10675	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A616_RS10685	COG1862	Preprotein translocase
A616_RS10695	COG0598	Magnesium transport protein CorA
A616_RS10700	COG2323	membrane
A616_RS10705	COG2244	polysaccharide biosynthetic process
A616_RS10715	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A616_RS10715	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A616_RS10720	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A616_RS10720	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A616_RS10725	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A616_RS10725	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A616_RS10730	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A616_RS10735	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A616_RS10740	COG1490	D-aminoacyl-tRNA deacylase activity
A616_RS10750	COG2318	DinB family
A616_RS10755	COG3103	Sh3 type 3 domain protein
A616_RS10755	COG0860	N-Acetylmuramoyl-L-alanine amidase
A616_RS10755	COG4991	sh3 domain protein
A616_RS10760	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A616_RS10765	COG0124	histidyl-tRNA synthetase
A616_RS10770	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A616_RS10780	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A616_RS10790	COG1959	2 iron, 2 sulfur cluster binding
A616_RS10795	COG1104	cysteine desulfurase activity
A616_RS10800	COG0840	transmembrane signaling receptor activity
A616_RS10805	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A616_RS10825	COG0861	Integral membrane protein TerC family
A616_RS10830	COG0628	permease
A616_RS10835	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A616_RS10840	COG4472	Bacterial protein of unknown function (DUF965)
A616_RS10850	COG3906	Belongs to the UPF0473 family
A616_RS10855	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A616_RS10860	COG4122	O-methyltransferase activity
A616_RS10865	COG0572	uridine kinase
A616_RS10870	COG0768	penicillin binding
A616_RS10890	COG1280	lysine exporter protein (LysE YggA)
A616_RS10905	COG0443	Heat shock 70 kDa protein
A616_RS10960	COG2801	Transposase and inactivated derivatives
A616_RS10965	COG2801	Transposase and inactivated derivatives
A616_RS10970	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A616_RS10995	COG1595	DNA-templated transcription, initiation
A616_RS11005	COG0456	acetyltransferase
A616_RS11050	COG1329	Transcriptional regulator
A616_RS11065	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A616_RS11085	COG3336	cytochrome c oxidase
A616_RS11090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A616_RS11100	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A616_RS11110	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A616_RS11115	COG0488	(ABC) transporter
A616_RS11125	COG1376	ErfK ybiS ycfS ynhG family protein
A616_RS11145	COG1413	lyase activity
A616_RS11150	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
A616_RS11160	COG4166	transmembrane transport
A616_RS11165	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A616_RS11175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A616_RS11180	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A616_RS11205	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A616_RS11210	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A616_RS11215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A616_RS11220	COG1534	Rna-binding protein
A616_RS11225	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A616_RS11230	COG1713	HD superfamily hydrolase involved in NAD metabolism
A616_RS11235	COG0799	negative regulation of ribosome biogenesis
A616_RS11240	COG2226	methyltransferase
A616_RS11245	COG0495	leucyl-tRNA aminoacylation
A616_RS11250	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A616_RS11260	COG0367	asparagine synthase
A616_RS11265	COG2333	competence protein COMEC
A616_RS11265	COG0658	competence protein
A616_RS11280	COG1466	dna polymerase III delta subunit
A616_RS11285	COG0268	Binds directly to 16S ribosomal RNA
A616_RS11295	COG0860	N-Acetylmuramoyl-L-alanine amidase
A616_RS11305	COG0444	Belongs to the ABC transporter superfamily
A616_RS11310	COG4608	Belongs to the ABC transporter superfamily
A616_RS11315	COG0747	negative chemotaxis
A616_RS11320	COG0601	transmembrane transport
A616_RS11325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A616_RS11335	COG0006	proline dipeptidase activity
A616_RS11340	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A616_RS11345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A616_RS11350	COG1120	ATPase activity
A616_RS11360	COG2964	Protein conserved in bacteria
A616_RS11375	COG2226	methyltransferase
A616_RS11380	COG1595	DNA-templated transcription, initiation
A616_RS11395	COG0481	GTPase activity
A616_RS11410	COG1196	nuclear chromosome segregation
A616_RS11410	COG0741	lytic transglycosylase activity
A616_RS11410	COG0739	heme binding
A616_RS11455	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A616_RS11460	COG1420	regulation of RNA biosynthetic process
A616_RS11470	COG0443	Heat shock 70 kDa protein
A616_RS11475	COG0484	heat shock protein binding
A616_RS11480	COG2264	protein methyltransferase activity
A616_RS11485	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A616_RS11490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A616_RS11500	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A616_RS11510	COG1346	cytolysis
A616_RS11515	COG1283	sodium-dependent phosphate transmembrane transporter activity
A616_RS11535	COG1181	Belongs to the D-alanine--D-alanine ligase family
A616_RS11560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A616_RS11570	COG1082	Xylose isomerase domain protein TIM barrel
A616_RS11580	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A616_RS11585	COG0537	adenosine 5'-monophosphoramidase activity
A616_RS11590	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A616_RS11595	COG1610	YqeY-like protein
A616_RS11600	COG1030	water channel activity
A616_RS11605	COG4864	UPF0365 protein
A616_RS11630	COG1702	phosphate starvation-inducible protein PhoH
A616_RS11635	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A616_RS11640	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A616_RS11645	COG0295	cytidine deaminase activity
A616_RS11650	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A616_RS11660	COG1381	Involved in DNA repair and RecF pathway recombination
A616_RS11665	COG0752	glycyl-tRNA synthetase alpha subunit
A616_RS11670	COG0751	glycine-tRNA ligase activity
A616_RS11675	COG0517	IMP dehydrogenase activity
A616_RS11680	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A616_RS11685	COG0358	DNA primase activity
A616_RS11690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A616_RS11700	COG1960	acyl-CoA dehydrogenase activity
A616_RS11710	COG2384	SAM-dependent methyltransferase
A616_RS11715	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A616_RS11725	COG3409	Peptidoglycan-binding domain 1 protein
A616_RS11725	COG0793	Belongs to the peptidase S41A family
A616_RS11790	COG1242	4 iron, 4 sulfur cluster binding
A616_RS11795	COG0584	glycerophosphoryl diester phosphodiesterase
A616_RS11800	COG0456	acetyltransferase
A616_RS11810	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A616_RS11815	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A616_RS11820	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A616_RS11825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A616_RS11830	COG1012	belongs to the aldehyde dehydrogenase family
A616_RS11840	COG0318	PFAM AMP-dependent synthetase and ligase
A616_RS11845	COG3876	Protein conserved in bacteria
A616_RS11865	COG1309	transcriptional regulator
A616_RS11905	COG0745	RESPONSE REGULATOR receiver
A616_RS11915	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A616_RS11920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A616_RS11935	COG0561	phosphatase activity
A616_RS11940	COG3842	ATPase activity
A616_RS11945	COG3835	regulator
A616_RS11950	COG1408	metallophosphoesterase
A616_RS11955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A616_RS11965	COG2072	flavoprotein involved in K transport
A616_RS11975	COG0701	Predicted permease
A616_RS11995	COG2197	response regulator
A616_RS12000	COG3850	Histidine kinase
A616_RS12005	COG0351	phosphomethylpyrimidine kinase
A616_RS12015	COG1595	DNA-templated transcription, initiation
A616_RS12030	COG1428	Deoxynucleoside kinase
A616_RS12035	COG1428	Deoxynucleoside kinase
A616_RS12055	COG2154	pterin-4-alpha-carbinolamine dehydratase
A616_RS12070	COG1607	acyl-coa hydrolase
A616_RS12075	COG0667	Aldo Keto reductase
A616_RS12085	COG3011	Protein conserved in bacteria
A616_RS12090	COG2986	histidine ammonia-lyase
A616_RS12110	COG4294	response to UV
A616_RS12115	COG3300	MHYT domain
A616_RS12115	COG5001	Diguanylate cyclase
A616_RS12145	COG1119	ATPase activity
A616_RS12175	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A616_RS12190	COG0477	Major facilitator Superfamily
A616_RS12200	COG0535	radical SAM domain protein
A616_RS12215	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A616_RS12230	COG2373	Large extracellular alpha-helical protein
A616_RS12235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A616_RS12240	COG1846	Transcriptional regulator
A616_RS12260	COG0243	molybdopterin cofactor binding
A616_RS12270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A616_RS12280	COG0367	asparagine synthase
A616_RS12285	COG3275	phosphorelay sensor kinase activity
A616_RS12290	COG3279	Response regulator of the LytR AlgR family
A616_RS12295	COG3162	membrane
A616_RS12300	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A616_RS12305	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A616_RS12315	COG4667	esterase of the alpha-beta hydrolase superfamily
A616_RS12345	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A616_RS12360	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A616_RS12365	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A616_RS12370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A616_RS12375	COG0765	amino acid transport
A616_RS12380	COG1126	abc transporter atp-binding protein
A616_RS12385	COG0183	Belongs to the thiolase family
A616_RS12395	COG0018	arginyl-trna synthetase
A616_RS12410	COG1595	DNA-templated transcription, initiation
A616_RS12425	COG1410	methionine synthase
A616_RS12425	COG0646	methionine synthase
A616_RS12430	COG0646	methionine synthase
A616_RS12430	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A616_RS12445	COG0300	oxidoreductase activity
A616_RS12450	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A616_RS12455	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A616_RS12480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A616_RS12485	COG0006	proline dipeptidase activity
A616_RS12490	COG1396	sequence-specific DNA binding
A616_RS12505	COG3739	integral membrane protein
A616_RS12520	COG4977	sequence-specific DNA binding
A616_RS12555	COG0346	lactoylglutathione lyase activity
A616_RS12560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A616_RS12565	COG1116	anion transmembrane transporter activity
A616_RS12570	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A616_RS12575	COG1234	tRNA 3'-trailer cleavage
A616_RS12600	COG1404	Belongs to the peptidase S8 family
A616_RS12610	COG1671	Belongs to the UPF0178 family
A616_RS12615	COG0671	phosphoesterase, PA-phosphatase related
A616_RS12620	COG0583	DNA-binding transcription factor activity
A616_RS12625	COG0477	Major facilitator Superfamily
A616_RS12630	COG0833	amino acid
A616_RS12640	COG3829	transcription factor binding
A616_RS12645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A616_RS12655	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A616_RS12660	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A616_RS12665	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A616_RS12675	COG4838	Belongs to the UPF0358 family
A616_RS12680	COG0733	neurotransmitter:sodium symporter activity
A616_RS12690	COG0387	Pfam Sodium calcium exchanger
A616_RS12705	COG0028	Belongs to the TPP enzyme family
A616_RS12715	COG0772	Belongs to the SEDS family
A616_RS12725	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
A616_RS12730	COG2226	methyltransferase
A616_RS12735	COG1525	nuclease
A616_RS12740	COG0840	transmembrane signaling receptor activity
A616_RS12740	COG5278	phosphoserine phosphatase activity
A616_RS12750	COG3300	MHYT domain
A616_RS12750	COG5001	Diguanylate cyclase
A616_RS12770	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A616_RS12780	COG0601	transmembrane transport
A616_RS12785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A616_RS12790	COG0444	Belongs to the ABC transporter superfamily
A616_RS12825	COG3546	catalase activity
A616_RS12830	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A616_RS12850	COG3679	Belongs to the UPF0342 family
A616_RS12865	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A616_RS12870	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A616_RS12875	COG4149	molybdate abc transporter
A616_RS12880	COG0725	ABC transporter, periplasmic molybdate-binding protein
A616_RS12885	COG1910	domain protein
A616_RS12895	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A616_RS12920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A616_RS12930	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A616_RS12935	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A616_RS12940	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A616_RS12945	COG0095	Lipoate-protein ligase
A616_RS12955	COG2234	aminopeptidase activity
A616_RS12965	COG0431	NADPH-dependent FMN reductase
A616_RS12970	COG1321	iron dependent repressor
A616_RS12975	COG1752	Esterase of the alpha-beta hydrolase superfamily
A616_RS12985	COG3872	metal-dependent enzyme
A616_RS12995	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A616_RS13000	COG0006	proline dipeptidase activity
A616_RS13005	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A616_RS13015	COG1595	DNA-templated transcription, initiation
A616_RS13025	COG2707	UPF0756 membrane protein
A616_RS13035	COG1809	phosphosulfolactate synthase activity
A616_RS13050	COG3854	ATPases associated with a variety of cellular activities
A616_RS13090	COG0511	ligase activity, forming carbon-carbon bonds
A616_RS13095	COG0439	Biotin carboxylase
A616_RS13100	COG1302	Protein conserved in bacteria
A616_RS13115	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A616_RS13120	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A616_RS13125	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A616_RS13130	COG1570	exodeoxyribonuclease VII activity
A616_RS13140	COG0142	geranyltranstransferase activity
A616_RS13150	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A616_RS13155	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A616_RS13160	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A616_RS13165	COG1438	arginine binding
A616_RS13170	COG0497	DNA recombination
A616_RS13175	COG0750	zinc metalloprotease
A616_RS13200	COG0288	reversible hydration of carbon dioxide
A616_RS13205	COG1408	metallophosphoesterase
A616_RS13210	COG0583	DNA-binding transcription factor activity
A616_RS13215	COG2226	methyltransferase
A616_RS13225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A616_RS13260	COG3829	transcription factor binding
A616_RS13260	COG3290	protein histidine kinase activity
A616_RS13265	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A616_RS13270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A616_RS13275	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A616_RS13280	COG0022	dehydrogenase e1 component
A616_RS13285	COG0508	dehydrogenase complex catalyzes the overall conversion of
A616_RS13295	COG0346	lactoylglutathione lyase activity
A616_RS13300	COG2195	Cleaves the N-terminal amino acid of tripeptides
A616_RS13315	COG0494	nUDIX hydrolase
A616_RS13320	COG1379	DNA repair
A616_RS13325	COG1300	Membrane
A616_RS13330	COG0735	belongs to the Fur family
A616_RS13340	COG4974	Belongs to the 'phage' integrase family
A616_RS13345	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A616_RS13355	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A616_RS13360	COG1522	sequence-specific DNA binding
A616_RS13365	COG4166	transmembrane transport
A616_RS13370	COG0601	transmembrane transport
A616_RS13375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A616_RS13380	COG0444	Belongs to the ABC transporter superfamily
A616_RS13385	COG4608	Belongs to the ABC transporter superfamily
A616_RS13390	COG0840	transmembrane signaling receptor activity
A616_RS13395	COG1686	Belongs to the peptidase S11 family
A616_RS13405	COG2172	sigma factor antagonist activity
A616_RS13430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A616_RS13445	COG0697	spore germination
A616_RS13455	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A616_RS13460	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A616_RS13465	COG1994	Peptidase M50
A616_RS13470	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A616_RS13475	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A616_RS13480	COG1686	Belongs to the peptidase S11 family
A616_RS13485	COG2715	membrane protein required for spore maturation
A616_RS13490	COG0700	Nucleoside recognition
A616_RS13495	COG1187	pseudouridine synthase activity
A616_RS13500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A616_RS13505	COG1333	cytochrome c biogenesis protein
A616_RS13510	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A616_RS13515	COG0745	RESPONSE REGULATOR receiver
A616_RS13520	COG5002	protein histidine kinase activity
A616_RS13535	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A616_RS13540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A616_RS13550	COG1141	Ferredoxin
A616_RS13565	COG0514	ATP-dependent DNA helicase (RecQ)
A616_RS13585	COG4862	establishment of competence for transformation
A616_RS13590	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A616_RS13595	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A616_RS13605	COG0252	asparaginase activity
A616_RS13610	COG2339	peptidase activity
A616_RS13615	COG3409	Peptidoglycan-binding domain 1 protein
A616_RS13615	COG3773	Cell wall hydrolase
A616_RS13620	COG2959	enzyme of heme biosynthesis
A616_RS13635	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A616_RS13645	COG0539	negative regulation of cytoplasmic translation
A616_RS13650	COG1304	FMN binding
A616_RS13670	COG1160	GTP binding
A616_RS13675	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A616_RS13715	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A616_RS13720	COG0776	regulation of translation
A616_RS13725	COG0302	gtp cyclohydrolase
A616_RS13735	COG0741	lytic transglycosylase activity
A616_RS13750	COG0142	geranyltranstransferase activity
A616_RS13760	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A616_RS13765	COG0163	prenyltransferase activity
A616_RS13770	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
A616_RS13780	COG0105	UTP biosynthetic process
A616_RS13785	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A616_RS13790	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A616_RS13795	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A616_RS13810	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A616_RS13815	COG0134	indole-3-glycerol-phosphate synthase activity
A616_RS13820	COG0135	phosphoribosylanthranilate isomerase activity
A616_RS13825	COG0133	tryptophan synthase activity
A616_RS13830	COG0159	tryptophan synthase activity
A616_RS13835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A616_RS13840	COG0287	Prephenate dehydrogenase
A616_RS13845	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A616_RS13855	COG1595	DNA-templated transcription, initiation
A616_RS13890	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A616_RS13910	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A616_RS13915	COG1694	Mazg nucleotide pyrophosphohydrolase
A616_RS13920	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A616_RS13925	COG1803	Methylglyoxal synthase
A616_RS13930	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A616_RS13935	COG0438	transferase activity, transferring glycosyl groups
A616_RS13940	COG0617	tRNA 3'-terminal CCA addition
A616_RS13950	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A616_RS13955	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A616_RS13960	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A616_RS13970	COG1199	ATP-dependent helicase activity
A616_RS13970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A616_RS13980	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A616_RS13985	COG0402	S-adenosylhomocysteine deaminase activity
A616_RS14005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A616_RS14015	COG0017	Asparaginyl-tRNA synthetase
A616_RS14020	COG3935	DnaD domain protein
A616_RS14040	COG0463	Glycosyl transferase, family 2
A616_RS14045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A616_RS14050	COG0438	transferase activity, transferring glycosyl groups
A616_RS14055	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A616_RS14060	COG1164	Oligoendopeptidase f
A616_RS14065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A616_RS14080	COG1666	GTP binding
A616_RS14095	COG0318	PFAM AMP-dependent synthetase and ligase
A616_RS14105	COG0066	3-isopropylmalate dehydratase activity
A616_RS14110	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A616_RS14115	COG0583	DNA-binding transcription factor activity
A616_RS14130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A616_RS14135	COG0564	pseudouridine synthase activity
A616_RS14150	COG0456	acetyltransferase
A616_RS14165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A616_RS14180	COG0154	amidase activity
A616_RS14185	COG1054	Belongs to the UPF0176 family
A616_RS14190	COG0756	dUTP diphosphatase activity
A616_RS14200	COG2072	flavoprotein involved in K transport
A616_RS14205	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A616_RS14210	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A616_RS14215	COG4208	sulfate ABC transporter
A616_RS14225	COG0488	(ABC) transporter
A616_RS14235	COG2508	Transcriptional regulator
A616_RS14245	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A616_RS14260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A616_RS14260	COG3153	acetyltransferase
A616_RS14265	COG0456	acetyltransferase
A616_RS14285	COG3829	transcription factor binding
A616_RS14285	COG3290	protein histidine kinase activity
A616_RS14290	COG1122	ATPase activity
A616_RS14300	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A616_RS14305	COG4684	Psort location CytoplasmicMembrane, score
A616_RS14310	COG3191	aminopeptidase activity
A616_RS14315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A616_RS14330	COG3103	Sh3 type 3 domain protein
A616_RS14330	COG0791	NLP P60 protein
A616_RS14330	COG1388	LysM domain
A616_RS14360	COG2720	vancomycin resistance protein
A616_RS14375	COG0791	NLP P60 protein
A616_RS14380	COG1309	transcriptional regulator
A616_RS14385	COG0318	PFAM AMP-dependent synthetase and ligase
A616_RS14390	COG2030	dehydratase
A616_RS14395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A616_RS14425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A616_RS14430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A616_RS14440	COG3546	catalase activity
A616_RS14460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A616_RS14475	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A616_RS14480	COG1388	LysM domain
A616_RS14480	COG3858	chitin binding
A616_RS14485	COG0492	ferredoxin-NADP+ reductase activity
A616_RS14490	COG0537	adenosine 5'-monophosphoramidase activity
A616_RS14500	COG1959	2 iron, 2 sulfur cluster binding
A616_RS14510	COG2169	Transcriptional regulator
A616_RS14510	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A616_RS14525	COG4302	ethanolamine ammonia-lyase activity
A616_RS14540	COG2378	regulation of single-species biofilm formation
A616_RS14545	COG3708	Transcriptional regulator
A616_RS14555	COG0745	RESPONSE REGULATOR receiver
A616_RS14560	COG5002	protein histidine kinase activity
A616_RS14565	COG1280	lysine exporter protein (LysE YggA)
A616_RS14570	COG2814	Major facilitator Superfamily
A616_RS14580	COG1733	regulation of RNA biosynthetic process
A616_RS14595	COG3191	aminopeptidase activity
A616_RS14600	COG1132	(ABC) transporter
A616_RS14610	COG5002	protein histidine kinase activity
A616_RS14615	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A616_RS14630	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A616_RS14635	COG1414	Transcriptional regulator
A616_RS14640	COG0444	Belongs to the ABC transporter superfamily
A616_RS14645	COG4608	Belongs to the ABC transporter superfamily
A616_RS14660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A616_RS14670	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
A616_RS14675	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A616_RS14680	COG1984	allophanate hydrolase subunit 2
A616_RS14685	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A616_RS14710	COG2309	aminopeptidase activity
A616_RS14715	COG1164	Oligoendopeptidase f
A616_RS14720	COG3695	enzyme binding
A616_RS14730	COG1199	ATP-dependent helicase activity
A616_RS14735	COG2132	Multicopper oxidase
A616_RS14750	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A616_RS14750	COG2755	lipolytic protein G-D-S-L family
A616_RS14755	COG0697	spore germination
A616_RS14775	COG0601	transmembrane transport
A616_RS14780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A616_RS14785	COG0444	Belongs to the ABC transporter superfamily
A616_RS14790	COG4608	Belongs to the ABC transporter superfamily
A616_RS14795	COG4166	transmembrane transport
A616_RS14805	COG0823	Involved in the tonB-independent uptake of proteins
A616_RS14805	COG4946	Tricorn protease homolog
A616_RS14805	COG1506	peptidase
A616_RS14810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A616_RS14815	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A616_RS14815	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A616_RS14825	COG1876	peptidase activity
A616_RS14830	COG1309	transcriptional regulator
A616_RS14835	COG0511	ligase activity, forming carbon-carbon bonds
A616_RS14845	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A616_RS14845	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A616_RS14855	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A616_RS14860	COG0511	ligase activity, forming carbon-carbon bonds
A616_RS14865	COG0439	Biotin carboxylase
A616_RS14895	COG0109	protoheme IX farnesyltransferase activity
A616_RS14920	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A616_RS14935	COG0586	Pfam SNARE associated Golgi protein
A616_RS14940	COG0402	S-adenosylhomocysteine deaminase activity
A616_RS14960	COG3483	tryptophan 2,3-dioxygenase activity
A616_RS14965	COG0714	Associated with various cellular activities
A616_RS14975	COG3552	Protein containing von Willebrand factor type A (VWA) domain
A616_RS15000	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A616_RS15025	COG1028	Short-chain dehydrogenase reductase Sdr
A616_RS15030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A616_RS15035	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A616_RS15040	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A616_RS15045	COG2011	ABC-type metal ion transport system permease component
A616_RS15050	COG1464	Belongs to the NlpA lipoprotein family
A616_RS15055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A616_RS15060	COG1473	amidohydrolase
A616_RS15065	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A616_RS15070	COG2011	ABC-type metal ion transport system permease component
A616_RS15075	COG1464	Belongs to the NlpA lipoprotein family
A616_RS15090	COG0583	DNA-binding transcription factor activity
A616_RS15095	COG0067	glutamate synthase
A616_RS15095	COG0070	glutamate synthase
A616_RS15095	COG0069	glutamate synthase activity
A616_RS15115	COG0346	lactoylglutathione lyase activity
A616_RS15125	COG1070	Carbohydrate kinase
A616_RS15130	COG1737	Transcriptional regulator
A616_RS15135	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A616_RS15160	COG1115	amino acid carrier protein
A616_RS15165	COG2066	Belongs to the glutaminase family
A616_RS15170	COG4191	Histidine kinase
A616_RS15175	COG0784	Response regulator, receiver
A616_RS15180	COG2267	carboxylic ester hydrolase activity
A616_RS15185	COG1309	transcriptional regulator
A616_RS15190	COG1802	Transcriptional regulator
A616_RS15215	COG1082	Xylose isomerase domain protein TIM barrel
A616_RS15225	COG1653	transport
A616_RS15270	COG0346	lactoylglutathione lyase activity
A616_RS15280	COG2249	NAD(P)H dehydrogenase (quinone) activity
A616_RS15290	COG1733	regulation of RNA biosynthetic process
A616_RS15300	COG1388	LysM domain
A616_RS15305	COG1510	regulation of RNA biosynthetic process
A616_RS15320	COG3829	transcription factor binding
A616_RS15320	COG3290	protein histidine kinase activity
A616_RS15330	COG1024	Enoyl-CoA hydratase
A616_RS15340	COG2086	electron transfer activity
A616_RS15345	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A616_RS15350	COG1012	belongs to the aldehyde dehydrogenase family
A616_RS15355	COG0318	PFAM AMP-dependent synthetase and ligase
A616_RS15365	COG2015	COG2015, Alkyl sulfatase and related hydrolases
A616_RS15375	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A616_RS15380	COG0183	Belongs to the thiolase family
A616_RS15385	COG1960	acyl-CoA dehydrogenase activity
A616_RS15390	COG0318	PFAM AMP-dependent synthetase and ligase
A616_RS15405	COG1960	acyl-CoA dehydrogenase activity
A616_RS15410	COG1028	Short-chain dehydrogenase reductase Sdr
A616_RS15415	COG2030	dehydratase
A616_RS15415	COG1012	belongs to the aldehyde dehydrogenase family
A616_RS15420	COG1960	acyl-CoA dehydrogenase activity
A616_RS15425	COG1028	Short-chain dehydrogenase reductase Sdr
A616_RS15430	COG0247	lactate metabolic process
A616_RS15430	COG2181	nitrate reductase activity
A616_RS15435	COG2514	catechol 2,3-dioxygenase activity
A616_RS15445	COG0488	(ABC) transporter
A616_RS15455	COG2404	hydrolase activity, acting on ester bonds
A616_RS15475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A616_RS15480	COG0444	Belongs to the ABC transporter superfamily
A616_RS15485	COG4608	Belongs to the ABC transporter superfamily
A616_RS15490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A616_RS15505	COG3832	glyoxalase III activity
A616_RS15510	COG0583	DNA-binding transcription factor activity
A616_RS15515	COG1024	Enoyl-CoA hydratase
A616_RS15525	COG0318	PFAM AMP-dependent synthetase and ligase
A616_RS15530	COG0183	Belongs to the thiolase family
A616_RS15535	COG1028	Short-chain dehydrogenase reductase Sdr
A616_RS15540	COG2030	dehydratase
A616_RS15550	COG1960	acyl-CoA dehydrogenase activity
A616_RS15575	COG2072	flavoprotein involved in K transport
A616_RS15580	COG1012	belongs to the aldehyde dehydrogenase family
A616_RS15590	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A616_RS15620	COG0488	(ABC) transporter
A616_RS15630	COG2814	Major facilitator Superfamily
A616_RS15650	COG2814	Major facilitator Superfamily
A616_RS15655	COG0628	permease
A616_RS15675	COG1132	(ABC) transporter
A616_RS15680	COG1132	(ABC) transporter
A616_RS15720	COG2207	Transcriptional regulator
A616_RS15740	COG1960	acyl-CoA dehydrogenase activity
A616_RS15750	COG2362	D-Aminopeptidase
A616_RS15765	COG0791	NLP P60 protein
A616_RS15770	COG0745	RESPONSE REGULATOR receiver
A616_RS15775	COG5002	protein histidine kinase activity
A616_RS15795	COG2258	MOSC domain
A616_RS15800	COG0662	Cupin 2, conserved barrel domain protein
A616_RS15805	COG4191	Histidine kinase
A616_RS15810	COG2364	Membrane
A616_RS15815	COG2814	Major facilitator Superfamily
A616_RS15820	COG4585	Histidine kinase
A616_RS15825	COG2197	response regulator
A616_RS15840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A616_RS15845	COG0730	response to heat
A616_RS15850	COG0601	transmembrane transport
A616_RS15855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A616_RS15860	COG0444	Belongs to the ABC transporter superfamily
A616_RS15865	COG4608	Belongs to the ABC transporter superfamily
A616_RS15870	COG4166	transmembrane transport
A616_RS15875	COG0006	proline dipeptidase activity
A616_RS15890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A616_RS15900	COG1396	sequence-specific DNA binding
A616_RS15915	COG0747	negative chemotaxis
A616_RS15920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A616_RS15925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A616_RS15950	COG3383	formate dehydrogenase (NAD+) activity
A616_RS15955	COG2427	Protein of unknown function (DUF1641)
A616_RS15965	COG5609	conserved protein (DUF2294)
A616_RS15970	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A616_RS15980	COG0303	'Molybdopterin
A616_RS15990	COG1309	transcriptional regulator
A616_RS16000	COG1024	Enoyl-CoA hydratase
A616_RS16010	COG1363	Peptidase, m42
A616_RS16015	COG0747	negative chemotaxis
A616_RS16020	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A616_RS16025	COG0601	transmembrane transport
A616_RS16030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A616_RS16035	COG0444	Belongs to the ABC transporter superfamily
A616_RS16040	COG4608	Belongs to the ABC transporter superfamily
A616_RS16045	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A616_RS16050	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A616_RS16055	COG2195	Cleaves the N-terminal amino acid of tripeptides
A616_RS16065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A616_RS16085	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A616_RS16100	COG0745	RESPONSE REGULATOR receiver
A616_RS16105	COG5002	protein histidine kinase activity
A616_RS16105	COG3850	Histidine kinase
A616_RS16115	COG2205	protein histidine kinase activity
A616_RS16135	COG0393	Putative heavy-metal-binding
A616_RS16155	COG0745	RESPONSE REGULATOR receiver
A616_RS16160	COG5002	protein histidine kinase activity
A616_RS16200	COG2368	4-hydroxyphenylacetate
A616_RS16205	COG0431	NADPH-dependent FMN reductase
A616_RS16230	COG3971	2-oxopent-4-enoate hydratase activity
A616_RS16235	COG4569	acetaldehyde dehydrogenase (acetylating) activity
A616_RS16240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A616_RS16250	COG1309	transcriptional regulator
A616_RS16265	COG0384	phenazine biosynthesis protein PhzF
A616_RS16275	COG2076	Multidrug Resistance protein
A616_RS16280	COG2076	Multidrug Resistance protein
A616_RS16285	COG1733	regulation of RNA biosynthetic process
A616_RS16290	COG0778	Nitroreductase
A616_RS16295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A616_RS16300	COG4224	UPF0291 protein
A616_RS16305	COG1959	2 iron, 2 sulfur cluster binding
A616_RS16335	COG0813	purine-nucleoside phosphorylase activity
A616_RS16350	COG1686	Belongs to the peptidase S11 family
A616_RS16355	COG2357	RelA SpoT domain protein
A616_RS16390	COG0714	Associated with various cellular activities
A616_RS16435	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A616_RS16490	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A616_RS16545	COG4112	unkown
A616_RS16555	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A616_RS16560	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A616_RS16565	COG1780	Probably involved in ribonucleotide reductase function
A616_RS16840	COG4474	Belongs to the UPF0398 family
A616_RS16965	COG4974	Belongs to the 'phage' integrase family
A616_RS17005	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A616_RS17045	COG2333	competence protein COMEC
A616_RS17045	COG0658	competence protein
A616_RS17140	COG2337	Toxic component of a toxin-antitoxin (TA) module
A616_RS17430	COG0582	viral genome integration into host DNA
A616_RS17435	COG0741	lytic transglycosylase activity
A616_RS17435	COG1196	nuclear chromosome segregation
A616_RS17435	COG0739	heme binding
A616_RS17435	COG0739	heme binding
A616_RS17435	COG0741	lytic transglycosylase activity
A616_RS17435	COG1196	nuclear chromosome segregation
A616_RS17455	COG2433	Pfam Transposase IS66
A616_RS17475	COG1396	sequence-specific DNA binding
A616_RS17560	COG3279	Response regulator of the LytR AlgR family
A616_RS17590	COG3949	Membrane
A616_RS17640	COG2814	Major facilitator Superfamily
A616_RS17670	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A616_RS17675	COG5001	Diguanylate cyclase
A616_RS17680	COG2249	NAD(P)H dehydrogenase (quinone) activity
A616_RS17740	COG0753	catalase activity
A616_RS17760	COG1278	Cold shock
A616_RS17770	COG2340	Cysteine-rich secretory protein family
A616_RS17780	COG0242	peptide deformylase activity
A616_RS17795	COG1024	Enoyl-CoA hydratase
A616_RS17805	COG2814	Major facilitator Superfamily
A616_RS17810	COG0640	Transcriptional regulator
A616_RS17815	COG1024	Enoyl-CoA hydratase
A616_RS17845	COG4978	Transcriptional regulator
A616_RS17845	COG0789	Transcriptional regulator
A616_RS17850	COG0596	Alpha beta hydrolase
A616_RS17855	COG2814	Major facilitator Superfamily
A616_RS17860	COG1309	transcriptional regulator
A616_RS17880	COG2249	NAD(P)H dehydrogenase (quinone) activity
A616_RS17895	COG0697	spore germination
A616_RS17905	COG3361	conserved protein (COG2071)
A616_RS17910	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A616_RS17910	COG0069	glutamate synthase activity
A616_RS17915	COG2311	Membrane
A616_RS17920	COG1114	Component of the transport system for branched-chain amino acids
A616_RS17930	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A616_RS17935	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A616_RS17940	COG2027	D-alanyl-D-alanine carboxypeptidase
A616_RS17965	COG0745	RESPONSE REGULATOR receiver
A616_RS17970	COG2205	protein histidine kinase activity
A616_RS17975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A616_RS17980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A616_RS17985	COG1116	anion transmembrane transporter activity
A616_RS17990	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A616_RS17995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A616_RS18000	COG2022	thiamine diphosphate biosynthetic process
A616_RS18005	COG2104	thiamine diphosphate biosynthetic process
A616_RS18015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A616_RS18025	COG3858	chitin binding
A616_RS18025	COG1388	LysM domain
A616_RS18030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A616_RS18035	COG0515	serine threonine protein kinase
A616_RS18080	COG2814	Major facilitator Superfamily
A616_RS18085	COG1733	regulation of RNA biosynthetic process
A616_RS18090	COG2249	NAD(P)H dehydrogenase (quinone) activity
A616_RS18095	COG0456	acetyltransferase
A616_RS18100	COG0318	PFAM AMP-dependent synthetase and ligase
A616_RS18110	COG2843	Capsule synthesis protein
A616_RS18155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A616_RS18175	COG1607	acyl-coa hydrolase
A616_RS18180	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A616_RS18185	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A616_RS18190	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A616_RS18195	COG1780	Probably involved in ribonucleotide reductase function
A616_RS18200	COG2819	hydrolase of the alpha beta superfamily
A616_RS18215	COG0482	sulfurtransferase activity
A616_RS18240	COG0584	glycerophosphoryl diester phosphodiesterase
A616_RS18255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A616_RS18270	COG0385	Bile acid
A616_RS18285	COG4122	O-methyltransferase activity
A616_RS18315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A616_RS18355	COG3964	amidohydrolase
A616_RS18365	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A616_RS18370	COG1011	Hydrolase
A616_RS18395	COG0840	transmembrane signaling receptor activity
A616_RS18400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A616_RS18410	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A616_RS18415	COG3835	regulator
A616_RS18475	COG1475	DNA binding
A616_RS18575	COG3093	addiction module antidote protein HigA
A616_RS18590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A616_RS18595	COG0785	Cytochrome C biogenesis protein
A616_RS18605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A616_RS18605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A616_RS18620	COG4585	Histidine kinase
A616_RS18625	COG2197	response regulator
A616_RS18635	COG3852	Histidine kinase
A616_RS18650	COG0352	thiamine-phosphate diphosphorylase activity
A616_RS18655	COG0352	thiamine-phosphate diphosphorylase activity
A616_RS18690	COG4565	transcriptional regulatory protein
A616_RS18695	COG3290	protein histidine kinase activity
A616_RS18700	COG1953	Uracil, thiamine, allantoin
A616_RS18705	COG0840	transmembrane signaling receptor activity
A616_RS18705	COG3290	protein histidine kinase activity
A616_RS18725	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A616_RS18725	COG0167	dihydroorotate dehydrogenase activity
A616_RS18730	COG0493	'glutamate synthase
A616_RS18755	COG1611	Belongs to the LOG family
A616_RS18760	COG1694	Mazg nucleotide pyrophosphohydrolase
A616_RS18765	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A616_RS18770	COG1012	belongs to the aldehyde dehydrogenase family
A616_RS18785	COG0464	growth
A616_RS18790	COG2814	Major facilitator Superfamily
A616_RS18795	COG1846	Transcriptional regulator
A616_RS18815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A616_RS18840	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A616_RS18845	COG0778	Nitroreductase
A616_RS18855	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A616_RS18860	COG0187	DNA topoisomerase II activity
A616_RS18885	COG1131	(ABC) transporter
A616_RS18900	COG1595	DNA-templated transcription, initiation
A616_RS18905	COG0626	cystathionine gamma-synthase activity
A616_RS18910	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A616_RS18920	COG1028	Short-chain dehydrogenase reductase Sdr
A616_RS18930	COG2707	UPF0756 membrane protein
A616_RS18955	COG4848	Belongs to the UPF0354 family
A616_RS18985	COG0488	(ABC) transporter
A616_RS19015	COG0508	dehydrogenase complex catalyzes the overall conversion of
A616_RS19020	COG0022	dehydrogenase e1 component
A616_RS19040	COG4166	transmembrane transport
A616_RS19055	COG3973	AAA domain
A616_RS19060	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A616_RS19065	COG4224	UPF0291 protein
A616_RS19070	COG3942	CHAP domain
A616_RS19070	COG1388	LysM domain
A616_RS19075	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A616_RS19100	COG3858	chitin binding
A616_RS19110	COG5566	PFAM Mor transcription activator
A616_RS19125	COG0640	Transcriptional regulator
A616_RS19135	COG1309	transcriptional regulator
A616_RS19180	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A616_RS19185	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A616_RS19220	COG3209	COG3209 Rhs family protein
A616_RS19225	COG2135	peptidase activity
A616_RS19240	COG2890	protein-(glutamine-N5) methyltransferase activity
A616_RS19245	COG2814	Major facilitator Superfamily
A616_RS19250	COG1309	transcriptional regulator
A616_RS19410	COG0582	viral genome integration into host DNA
A616_RS19420	COG0174	glutamine synthetase
A616_RS19425	COG0789	Transcriptional regulator
A616_RS19430	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
A616_RS19435	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A616_RS19460	COG0464	growth
A616_RS19470	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A616_RS19475	COG1846	Transcriptional regulator
A616_RS19480	COG2814	Major facilitator Superfamily
A616_RS19485	COG2764	glyoxalase bleomycin resistance protein dioxygenase
A616_RS19490	COG1923	regulation of RNA biosynthetic process
A616_RS19495	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A616_RS19500	COG2136	Putative SAM-dependent methyltransferase
A616_RS19500	COG2521	methyltransferase
A616_RS19515	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A616_RS19520	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A616_RS19535	COG4550	Control of competence regulator ComK, YlbF/YmcA
A616_RS19545	COG3693	PFAM glycoside hydrolase, family 10
A616_RS19550	COG0095	Lipoate-protein ligase
A616_RS19560	COG0517	IMP dehydrogenase activity
A616_RS19570	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A616_RS19575	COG1234	tRNA 3'-trailer cleavage
A616_RS19580	COG3949	Membrane
A616_RS19585	COG1013	pyruvate-flavodoxin oxidoreductase activity
A616_RS19590	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A616_RS19590	COG0674	pyruvate-flavodoxin oxidoreductase activity
A616_RS19600	COG2359	stage V sporulation protein S
A616_RS19605	COG1692	metallophosphoesterase
A616_RS19615	COG2137	regulation of response to DNA damage stimulus
A616_RS19620	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A616_RS19625	COG0513	Belongs to the DEAD box helicase family
A616_RS19630	COG1058	Belongs to the CinA family
A616_RS19630	COG1546	Belongs to the CinA family
A616_RS19635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A616_RS19640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A616_RS19645	COG1426	Protein conserved in bacteria
A616_RS19660	COG0300	oxidoreductase activity
A616_RS19665	COG0612	Peptidase, M16
A616_RS19670	COG0612	Peptidase, M16
A616_RS19680	COG1079	Belongs to the binding-protein-dependent transport system permease family
A616_RS19685	COG4603	Belongs to the binding-protein-dependent transport system permease family
A616_RS19690	COG3845	ABC transporter
A616_RS19695	COG1744	ABC transporter substrate-binding protein PnrA-like
A616_RS19700	COG2188	Transcriptional regulator
A616_RS19705	COG1674	ftsk spoiiie
A616_RS19705	COG4980	gas vesicle protein
A616_RS19715	COG0740	serine-type endopeptidase activity
A616_RS19720	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A616_RS19725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A616_RS19730	COG0527	aspartate kinase activity
A616_RS19735	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A616_RS19740	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A616_RS19745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A616_RS19750	COG1873	PFAM PRC-barrel domain
A616_RS19755	COG0612	Peptidase, M16
A616_RS19760	COG0726	polysaccharide deacetylase
A616_RS19765	COG1185	polyribonucleotide nucleotidyltransferase activity
A616_RS19770	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A616_RS19775	COG0196	riboflavin kinase activity
A616_RS19780	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A616_RS19785	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A616_RS19790	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A616_RS19800	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A616_RS19800	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A616_RS19805	COG1358	cellular component organization or biogenesis
A616_RS19815	COG0195	Participates in both transcription termination and antitermination
A616_RS19820	COG0779	Required for maturation of 30S ribosomal subunits
A616_RS19825	COG2176	DNA-directed DNA polymerase activity
A616_RS19830	COG0442	prolyl-tRNA aminoacylation
A616_RS19835	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A616_RS19840	COG0750	zinc metalloprotease
A616_RS19845	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A616_RS19850	COG4589	Belongs to the CDS family
A616_RS19855	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A616_RS19860	COG0233	cytoplasmic translational termination
A616_RS19865	COG0528	UMP kinase activity
A616_RS19870	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A616_RS19875	COG0052	Belongs to the universal ribosomal protein uS2 family
A616_RS19900	COG1191	sigma factor activity
A616_RS19910	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A616_RS19915	COG1776	CheC inhibitor of MCP methylation
A616_RS19920	COG0835	chemotaxis
A616_RS19925	COG2198	Histidine kinase
A616_RS19925	COG0643	Histidine kinase
A616_RS19930	COG2201	protein-glutamate methylesterase activity
A616_RS19935	COG0455	bacterial-type flagellum organization
A616_RS19940	COG1419	protein localization to endoplasmic reticulum
A616_RS19945	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A616_RS19950	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A616_RS19955	COG1684	flagellar biosynthetic protein fliR
A616_RS19960	COG1987	bacterial-type flagellum assembly
A616_RS19965	COG1338	Plays a role in the flagellum-specific transport system
A616_RS19970	COG3190	flagellar
A616_RS19975	COG2201	protein-glutamate methylesterase activity
A616_RS19980	COG1776	CheC inhibitor of MCP methylation
A616_RS19980	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A616_RS19985	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A616_RS20000	COG4786	Flagellar basal body rod
A616_RS20025	COG1157	protein secretion by the type III secretion system
A616_RS20035	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A616_RS20040	COG1766	The M ring may be actively involved in energy transduction
A616_RS20045	COG1677	Flagellar hook-basal body complex protein FliE
A616_RS20050	COG1558	bacterial-type flagellum-dependent cell motility
A616_RS20055	COG1815	bacterial-type flagellum-dependent cell motility
A616_RS20060	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A616_RS20065	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A616_RS20070	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A616_RS20075	COG4974	Belongs to the 'phage' integrase family
A616_RS20080	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A616_RS20085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A616_RS20090	COG0758	DNA mediated transformation
A616_RS20095	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A616_RS20100	COG0045	succinate-CoA ligase (ADP-forming) activity
A616_RS20120	COG0393	Putative heavy-metal-binding
A616_RS20125	COG5001	Diguanylate cyclase
A616_RS20135	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A616_RS20150	COG0606	chelatase, subunit chli
A616_RS20160	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
A616_RS20180	COG3541	Predicted nucleotidyltransferase
A616_RS20195	COG2257	FlhB HrpN YscU SpaS Family
A616_RS20205	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A616_RS20215	COG0681	Belongs to the peptidase S26 family
A616_RS20220	COG0335	large ribosomal subunit rRNA binding
A616_RS20225	COG0336	Belongs to the RNA methyltransferase TrmD family
A616_RS20230	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A616_RS20240	COG1837	Belongs to the UPF0109 family
A616_RS20245	COG0228	four-way junction DNA binding
A616_RS20250	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A616_RS20255	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
A616_RS20260	COG0552	protein localization to endoplasmic reticulum
A616_RS20265	COG1196	nuclear chromosome segregation
A616_RS20270	COG0571	ribonuclease III activity
A616_RS20275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A616_RS20280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A616_RS20285	COG1028	Short-chain dehydrogenase reductase Sdr
A616_RS20290	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A616_RS20295	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A616_RS20300	COG0416	fatty acid biosynthetic process
A616_RS20305	COG1349	DNA-binding transcription factor activity
A616_RS20305	COG2050	protein possibly involved in aromatic compounds catabolism
A616_RS20310	COG4555	ABC transporter
A616_RS20325	COG1349	DNA-binding transcription factor activity
A616_RS20330	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A616_RS20340	COG3480	Lon protease (S16) C-terminal proteolytic domain
A616_RS20345	COG1752	Esterase of the alpha-beta hydrolase superfamily
A616_RS20350	COG3314	Sporulation integral membrane protein YlbJ
A616_RS20355	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A616_RS20360	COG0742	ribosomal rna small subunit methyltransferase
A616_RS20370	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A616_RS20375	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A616_RS20380	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A616_RS20390	COG1793	dna ligase
A616_RS20410	COG0697	spore germination
A616_RS20415	COG1793	dna ligase
A616_RS20415	COG3285	dna ligase
A616_RS20420	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A616_RS20430	COG0306	phosphate transporter
A616_RS20440	COG2199	diguanylate cyclase activity
A616_RS20440	COG2203	Gaf domain
A616_RS20445	COG3424	synthase
A616_RS20450	COG1755	Isoprenylcysteine carboxyl methyltransferase
A616_RS20475	COG1846	Transcriptional regulator
A616_RS20480	COG0681	Belongs to the peptidase S26 family
A616_RS20485	COG1876	peptidase activity
A616_RS20495	COG0405	Gamma-glutamyltransferase
A616_RS20500	COG5434	Belongs to the glycosyl hydrolase 28 family
A616_RS20500	COG4632	Exopolysaccharide biosynthesis protein
A616_RS20525	COG0714	Associated with various cellular activities
A616_RS20550	COG0438	transferase activity, transferring glycosyl groups
A616_RS20555	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A616_RS20560	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A616_RS20575	COG1027	Aspartate ammonia-lyase
A616_RS20585	COG5522	Integral membrane protein (intg_mem_TP0381)
A616_RS20590	COG0583	DNA-binding transcription factor activity
A616_RS20605	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A616_RS20610	COG0477	Major facilitator Superfamily
A616_RS20615	COG1132	(ABC) transporter
A616_RS20635	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A616_RS20650	COG3708	Transcriptional regulator
A616_RS20650	COG2207	Transcriptional regulator
A616_RS20670	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A616_RS20675	COG1760	l-serine dehydratase
A616_RS20680	COG1760	l-serine dehydratase
A616_RS20690	COG1307	EDD domain protein, DegV family
A616_RS20695	COG1461	Dihydroxyacetone kinase
A616_RS20700	COG1302	Protein conserved in bacteria
A616_RS20705	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A616_RS20715	COG3859	Proton-coupled thiamine transporter YuaJ
A616_RS20720	COG1126	abc transporter atp-binding protein
A616_RS20725	COG0765	amino acid transport
A616_RS20730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A616_RS20740	COG1714	RDD family
A616_RS20750	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A616_RS20755	COG1162	GTPase activity
A616_RS20760	COG2815	serine threonine protein kinase
A616_RS20760	COG0515	serine threonine protein kinase
A616_RS20765	COG0631	protein serine/threonine phosphatase activity
A616_RS20770	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A616_RS20775	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A616_RS20775	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A616_RS20780	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A616_RS20785	COG0242	peptide deformylase activity
A616_RS20790	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A616_RS20795	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A616_RS20800	COG1758	RNA polymerase activity
A616_RS20805	COG0194	GDP metabolic process
A616_RS20810	COG2052	Domain of unknown function (DUF370)
A616_RS20815	COG1561	YicC-like family, N-terminal region
A616_RS20820	COG1293	RNA-binding protein homologous to eukaryotic snRNP
A616_RS20845	COG1024	Enoyl-CoA hydratase
A616_RS20850	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A616_RS20880	COG1547	Domain of unknown function (DUF309)
A616_RS20900	COG4846	Membrane protein involved in cytochrome C biogenesis
A616_RS20915	COG0460	homoserine dehydrogenase
A616_RS20920	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A616_RS20930	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A616_RS20935	COG0673	inositol 2-dehydrogenase activity
A616_RS20940	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A616_RS20945	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A616_RS20950	COG1222	aaa ATPase
A616_RS20980	COG0640	Transcriptional regulator
A616_RS21000	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A616_RS21010	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A616_RS21015	COG0540	Belongs to the ATCase OTCase family
A616_RS21025	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A616_RS21040	COG0564	pseudouridine synthase activity
A616_RS21045	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A616_RS21050	COG2112	serine threonine protein kinase
A616_RS21060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A616_RS21070	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A616_RS21105	COG1842	Phage shock protein A
A616_RS21110	COG0551	DNA topoisomerase type I activity
A616_RS21110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A616_RS21120	COG1657	PFAM Prenyltransferase squalene oxidase
A616_RS21160	COG3848	Pyruvate phosphate dikinase
A616_RS21160	COG0574	Belongs to the PEP-utilizing enzyme family
A616_RS21170	COG1316	TRANSCRIPTIONal
A616_RS21175	COG0492	ferredoxin-NADP+ reductase activity
A616_RS21180	COG0494	nUDIX hydrolase
A616_RS21185	COG2814	Major facilitator Superfamily
A616_RS21190	COG4948	Mandelate Racemase Muconate Lactonizing
A616_RS21195	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A616_RS21200	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A616_RS21205	COG3599	regulation of cell shape
A616_RS21210	COG2302	S4 RNA-binding domain
A616_RS21215	COG0762	integral membrane protein
A616_RS21220	COG1799	cell septum assembly
A616_RS21225	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A616_RS21230	COG1496	oxidoreductase activity
A616_RS21235	COG1873	PFAM PRC-barrel domain
A616_RS21240	COG1191	sigma factor activity
A616_RS21245	COG1191	sigma factor activity
A616_RS21255	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A616_RS21260	COG0849	cell division
A616_RS21265	COG3856	small basic protein
A616_RS21280	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A616_RS21285	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A616_RS21290	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A616_RS21295	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A616_RS21300	COG0772	Belongs to the SEDS family
A616_RS21305	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A616_RS21310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A616_RS21320	COG0768	penicillin binding
A616_RS21325	COG0768	penicillin binding
A616_RS21335	COG0275	rRNA processing
A616_RS21340	COG2001	Belongs to the MraZ family
A616_RS21345	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A616_RS21350	COG0583	DNA-binding transcription factor activity
A616_RS21355	COG0531	amino acid
A616_RS21360	COG3266	domain, Protein
A616_RS21360	COG2911	Protein conserved in bacteria
A616_RS21360	COG1361	Conserved repeat domain
A616_RS21365	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
A616_RS21380	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A616_RS21385	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A616_RS21390	COG1024	Enoyl-CoA hydratase
A616_RS21395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A616_RS21400	COG0511	ligase activity, forming carbon-carbon bonds
A616_RS21405	COG0439	Biotin carboxylase
A616_RS21410	COG0454	-acetyltransferase
A616_RS21420	COG1024	Enoyl-CoA hydratase
A616_RS21425	COG1393	Belongs to the ArsC family
A616_RS21450	COG2843	Capsule synthesis protein
A616_RS21455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A616_RS21480	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A616_RS21490	COG0626	cystathionine gamma-synthase activity
A616_RS21495	COG0626	cystathionine gamma-synthase activity
A616_RS21525	COG0386	Belongs to the glutathione peroxidase family
A616_RS21530	COG1217	gtp-binding protein TYPA
A616_RS21540	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A616_RS21570	COG4493	Belongs to the UPF0637 family
A616_RS21580	COG1982	Orn Lys Arg decarboxylase major
A616_RS21585	COG0167	dihydroorotate dehydrogenase activity
A616_RS21600	COG2267	carboxylic ester hydrolase activity
A616_RS21620	COG1705	Flagellar rod assembly protein muramidase FlgJ
A616_RS21635	COG1473	amidohydrolase
A616_RS21640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A616_RS21645	COG2171	N-acyltransferase activity
A616_RS21650	COG0716	FMN binding
A616_RS21660	COG2217	Heavy metal translocating P-type atpase
A616_RS21675	COG2226	methyltransferase
A616_RS21690	COG0577	efflux transmembrane transporter activity
A616_RS21695	COG0577	efflux transmembrane transporter activity
A616_RS21695	COG1136	(ABC) transporter
A616_RS21700	COG0351	phosphomethylpyrimidine kinase
A616_RS21705	COG2962	Rard protein
A616_RS21760	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A616_RS21785	COG4991	sh3 domain protein
A616_RS21785	COG0860	N-Acetylmuramoyl-L-alanine amidase
A616_RS21785	COG3103	Sh3 type 3 domain protein
A616_RS21805	COG1120	ATPase activity
A616_RS21810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A616_RS21820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A616_RS21830	COG0789	Transcriptional regulator
A616_RS21835	COG1227	inorganic diphosphatase activity
A616_RS21855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A616_RS21860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A616_RS21865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A616_RS21870	COG0778	Nitroreductase
A616_RS21880	COG1028	Short-chain dehydrogenase reductase Sdr
A616_RS21910	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A616_RS21915	COG0316	Belongs to the HesB IscA family
A616_RS21920	COG2814	Major facilitator Superfamily
A616_RS21925	COG1193	negative regulation of DNA recombination
A616_RS21940	COG1695	Transcriptional regulator
A616_RS21955	COG1231	oxidoreductase activity
A616_RS21960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A616_RS21985	COG0786	glutamate:sodium symporter activity
A616_RS21995	COG0583	DNA-binding transcription factor activity
A616_RS22020	COG0367	asparagine synthase
A616_RS22030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A616_RS22030	COG1028	Short-chain dehydrogenase reductase Sdr
A616_RS22030	COG3321	synthase
A616_RS22030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A616_RS22030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A616_RS22035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A616_RS22035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A616_RS22035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A616_RS22035	COG1028	Short-chain dehydrogenase reductase Sdr
A616_RS22035	COG3321	synthase
A616_RS22040	COG1028	Short-chain dehydrogenase reductase Sdr
A616_RS22040	COG4221	oxidoreductase activity
A616_RS22040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A616_RS22040	COG3321	synthase
A616_RS22045	COG3321	synthase
A616_RS22045	COG4221	oxidoreductase activity
A616_RS22045	COG1028	Short-chain dehydrogenase reductase Sdr
A616_RS22045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A616_RS22050	COG1028	Short-chain dehydrogenase reductase Sdr
A616_RS22050	COG3321	synthase
A616_RS22050	COG4221	oxidoreductase activity
A616_RS22050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A616_RS22060	COG2267	carboxylic ester hydrolase activity
A616_RS22065	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A616_RS22065	COG2070	2-Nitropropane dioxygenase
A616_RS22075	COG0250	Participates in transcription elongation, termination and antitermination
A616_RS22165	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A616_RS22175	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A616_RS22210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A616_RS22220	COG1253	flavin adenine dinucleotide binding
A616_RS22225	COG0210	DNA helicase
A616_RS22250	COG0861	Integral membrane protein TerC family
A616_RS22275	COG0835	chemotaxis
A616_RS22285	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A616_RS22300	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A616_RS22310	COG4533	DNA binding
A616_RS22315	COG0477	Major facilitator Superfamily
A616_RS22315	COG2814	Major facilitator Superfamily
A616_RS22320	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A616_RS22320	COG1116	anion transmembrane transporter activity
A616_RS22325	COG4120	Belongs to the binding-protein-dependent transport system permease family
A616_RS22340	COG1253	flavin adenine dinucleotide binding
A616_RS22350	COG1595	DNA-templated transcription, initiation
A616_RS22380	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A616_RS22385	COG1131	(ABC) transporter
A616_RS22395	COG2211	Major facilitator Superfamily
A616_RS22400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A616_RS22410	COG1902	pentaerythritol trinitrate reductase activity
A616_RS22410	COG0446	pyridine nucleotide-disulphide oxidoreductase
A616_RS22425	COG1316	TRANSCRIPTIONal
A616_RS22435	COG2223	nitrite transmembrane transporter activity
A616_RS22440	COG0653	protein targeting
A616_RS22460	COG3481	metal-dependent phosphohydrolase, HD sub domain
A616_RS22470	COG0586	Pfam SNARE associated Golgi protein
A616_RS22490	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A616_RS22495	COG0024	Methionine aminopeptidase
A616_RS22500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A616_RS22505	COG1309	transcriptional regulator
A616_RS22520	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A616_RS22525	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
A616_RS22530	COG0179	Fumarylacetoacetate (FAA) hydrolase
A616_RS22535	COG0564	pseudouridine synthase activity
A616_RS22545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A616_RS22555	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A616_RS22570	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A616_RS22580	COG3874	Sporulation protein YtfJ
A616_RS22590	COG1388	LysM domain
A616_RS22590	COG3584	3D domain protein
A616_RS22605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A616_RS22615	COG2323	membrane
A616_RS22630	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A616_RS22635	COG0726	polysaccharide deacetylase
A616_RS22640	COG0861	Integral membrane protein TerC family
A616_RS22645	COG4191	Histidine kinase
A616_RS22745	COG0179	Fumarylacetoacetate (FAA) hydrolase
A616_RS22750	COG0301	tRNA thio-modification
A616_RS22755	COG1104	cysteine desulfurase activity
A616_RS22760	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A616_RS22775	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
A616_RS22785	COG4221	oxidoreductase activity
A616_RS22815	COG4948	Mandelate Racemase Muconate Lactonizing
A616_RS22820	COG4608	Belongs to the ABC transporter superfamily
A616_RS22825	COG0444	Belongs to the ABC transporter superfamily
A616_RS22830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A616_RS22840	COG0747	negative chemotaxis
A616_RS22855	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A616_RS22865	COG4326	sporulation control protein
A616_RS22895	COG1363	Peptidase, m42
A616_RS22905	COG2081	HI0933 family
A616_RS22915	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
A616_RS22930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A616_RS22935	COG2203	Gaf domain
A616_RS22935	COG2199	diguanylate cyclase activity
A616_RS22950	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A616_RS22960	COG0454	-acetyltransferase
A616_RS22965	COG0517	IMP dehydrogenase activity
A616_RS22970	COG0123	including yeast histone deacetylase and acetoin utilization protein
A616_RS22975	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A616_RS22990	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A616_RS22990	COG1605	Chorismate mutase
A616_RS23000	COG3118	belongs to the thioredoxin family
A616_RS23020	COG2309	aminopeptidase activity
A616_RS23025	COG1695	Transcriptional regulator
A616_RS23040	COG1733	regulation of RNA biosynthetic process
A616_RS23050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A616_RS23070	COG2267	carboxylic ester hydrolase activity
A616_RS23075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A616_RS23085	COG0436	Aminotransferase
A616_RS23090	COG2814	Major facilitator Superfamily
A616_RS23095	COG0315	cyclic pyranopterin monophosphate synthase activity
A616_RS23100	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A616_RS23115	COG0314	molybdopterin synthase activity
A616_RS23120	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A616_RS23125	COG5002	protein histidine kinase activity
A616_RS23130	COG0745	RESPONSE REGULATOR receiver
A616_RS23135	COG1132	(ABC) transporter
A616_RS23145	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A616_RS23165	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A616_RS23180	COG0604	alcohol dehydrogenase
A616_RS23185	COG1414	Transcriptional regulator
A616_RS23190	COG0656	L-ascorbic acid biosynthetic process
A616_RS23275	COG0464	growth
A616_RS23305	COG1228	amidohydrolase
A616_RS23310	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A616_RS23315	COG2207	Transcriptional regulator
A616_RS23325	COG3829	transcription factor binding
A616_RS23330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A616_RS23335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A616_RS23370	COG1181	Belongs to the D-alanine--D-alanine ligase family
A616_RS23380	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A616_RS23390	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A616_RS23410	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A616_RS23425	COG0489	protein tyrosine kinase activity
A616_RS23435	COG1316	TRANSCRIPTIONal
A616_RS23465	COG1674	ftsk spoiiie
A616_RS23475	COG0529	Catalyzes the synthesis of activated sulfate
A616_RS23480	COG2046	Belongs to the sulfate adenylyltransferase family
A616_RS23485	COG0175	sulfate reduction
A616_RS23490	COG1587	Uroporphyrinogen-III synthase
A616_RS23490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A616_RS23500	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A616_RS23515	COG2162	N-hydroxyarylamine O-acetyltransferase activity
A616_RS23520	COG0583	DNA-binding transcription factor activity
A616_RS23525	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A616_RS23550	COG0483	inositol monophosphate 1-phosphatase activity
A616_RS23565	COG0129	dihydroxy-acid dehydratase activity
A616_RS23580	COG0791	NLP P60 protein
A616_RS23590	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A616_RS23600	COG4565	transcriptional regulatory protein
A616_RS23605	COG3290	protein histidine kinase activity
A616_RS23610	COG2851	Citrate transporter
A616_RS23635	COG0667	Aldo Keto reductase
A616_RS23660	COG1131	(ABC) transporter
A616_RS23695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A616_RS23710	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A616_RS23715	COG0531	amino acid
A616_RS23720	COG1349	DNA-binding transcription factor activity
A616_RS23730	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A616_RS23730	COG0446	pyridine nucleotide-disulphide oxidoreductase
A616_RS23740	COG0840	transmembrane signaling receptor activity
A616_RS23780	COG0488	(ABC) transporter
A616_RS23800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A616_RS23805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A616_RS23810	COG0765	amino acid transport
A616_RS23815	COG1126	abc transporter atp-binding protein
A616_RS23845	COG0778	Nitroreductase
A616_RS23850	COG2755	lipolytic protein G-D-S-L family
A616_RS23860	COG0583	DNA-binding transcription factor activity
A616_RS23865	COG0456	acetyltransferase
A616_RS23870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A616_RS23875	COG0697	spore germination
A616_RS23890	COG3387	PFAM Glycoside hydrolase 15-related
A616_RS23895	COG0483	inositol monophosphate 1-phosphatase activity
A616_RS23905	COG1966	Carbon starvation protein
A616_RS23920	COG3275	phosphorelay sensor kinase activity
A616_RS23935	COG3185	4-Hydroxyphenylpyruvate dioxygenase
A616_RS23940	COG3118	belongs to the thioredoxin family
A616_RS23945	COG1959	2 iron, 2 sulfur cluster binding
A616_RS23950	COG2226	methyltransferase
A616_RS23975	COG0745	RESPONSE REGULATOR receiver
A616_RS24000	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A616_RS24000	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A616_RS24010	COG1280	lysine exporter protein (LysE YggA)
A616_RS24015	COG1522	sequence-specific DNA binding
A616_RS24025	COG1363	Peptidase, m42
A616_RS24030	COG2814	Major facilitator Superfamily
A616_RS24040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A616_RS24045	COG2357	RelA SpoT domain protein
A616_RS24050	COG3290	protein histidine kinase activity
A616_RS24050	COG0840	transmembrane signaling receptor activity
A616_RS24065	COG4166	transmembrane transport
A616_RS24070	COG2205	protein histidine kinase activity
A616_RS24075	COG0826	peptidase U32
A616_RS24090	COG1595	DNA-templated transcription, initiation
A616_RS24095	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A616_RS24115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A616_RS24125	COG0189	ligase activity
A616_RS24130	COG1473	amidohydrolase
A616_RS24145	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A616_RS24150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A616_RS24170	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A616_RS24200	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A616_RS24205	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A616_RS24210	COG0697	spore germination
A616_RS24215	COG0531	amino acid
A616_RS24230	COG0745	RESPONSE REGULATOR receiver
A616_RS24230	COG2972	Histidine kinase
A616_RS24235	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A616_RS24240	COG3279	Response regulator of the LytR AlgR family
A616_RS24265	COG0346	lactoylglutathione lyase activity
A616_RS24270	COG0840	transmembrane signaling receptor activity
A616_RS24300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A616_RS24325	COG4549	nuclear export factor GLE1
A616_RS24355	COG1177	transmembrane transport
A616_RS24360	COG1176	ABC-type spermidine putrescine transport system, permease component I
A616_RS24370	COG0697	spore germination
A616_RS24375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A616_RS24385	COG0542	response to heat
A616_RS24390	COG2814	Major facilitator Superfamily
A616_RS24395	COG1309	transcriptional regulator
A616_RS24400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A616_RS24405	COG1515	deoxyribonuclease V activity
A616_RS24420	COG3433	isochorismatase activity
A616_RS24420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A616_RS24420	COG2226	methyltransferase
A616_RS24425	COG1028	Short-chain dehydrogenase reductase Sdr
A616_RS24425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A616_RS24425	COG3321	synthase
A616_RS24425	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A616_RS24425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A616_RS24435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A616_RS24435	COG2226	methyltransferase
A616_RS24435	COG3433	isochorismatase activity
A616_RS24440	COG1021	2,3-dihydroxybenzoate-AMP ligase
A616_RS24445	COG2091	lysine biosynthetic process via aminoadipic acid
A616_RS24575	COG0631	protein serine/threonine phosphatase activity
A616_RS24610	COG2815	serine threonine protein kinase
A616_RS24610	COG0515	serine threonine protein kinase
A616_RS24620	COG2211	Major facilitator Superfamily
A616_RS24630	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A616_RS24635	COG2070	2-Nitropropane dioxygenase
A616_RS24645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A616_RS24650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A616_RS24655	COG2207	Transcriptional regulator
A616_RS24675	COG1349	DNA-binding transcription factor activity
A616_RS24685	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A616_RS24690	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A616_RS24690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A616_RS24700	COG3842	ATPase activity
A616_RS24705	COG1840	ABC-type Fe3 transport system, periplasmic component
A616_RS24715	COG1794	racemase activity, acting on amino acids and derivatives
A616_RS24725	COG0655	NAD(P)H dehydrogenase (quinone) activity
A616_RS24730	COG0346	lactoylglutathione lyase activity
A616_RS24740	COG0583	DNA-binding transcription factor activity
A616_RS24745	COG2388	GCN5-related N-acetyl-transferase
A616_RS24755	COG0400	carboxylic ester hydrolase activity
A616_RS24760	COG0346	lactoylglutathione lyase activity
A616_RS24775	COG2814	Major facilitator Superfamily
A616_RS24800	COG1335	isochorismatase
A616_RS24805	COG0783	Belongs to the Dps family
A616_RS24815	COG1335	isochorismatase
A616_RS24820	COG2267	carboxylic ester hydrolase activity
A616_RS24825	COG4753	response regulator
A616_RS24825	COG2207	Transcriptional regulator
A616_RS24830	COG3275	phosphorelay sensor kinase activity
A616_RS24840	COG0583	DNA-binding transcription factor activity
A616_RS24845	COG0583	DNA-binding transcription factor activity
A616_RS24850	COG4474	Belongs to the UPF0398 family
A616_RS24865	COG0590	tRNA wobble adenosine to inosine editing
A616_RS24870	COG0549	Belongs to the carbamate kinase family
A616_RS24875	COG1953	Uracil, thiamine, allantoin
A616_RS24880	COG1304	FMN binding
A616_RS24885	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A616_RS24895	COG0666	response to abiotic stimulus
A616_RS24900	COG2508	Transcriptional regulator
A616_RS24900	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A616_RS24940	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A616_RS24945	COG2971	BadF BadG BcrA BcrD
A616_RS24950	COG0165	Argininosuccinate lyase
A616_RS24970	COG3842	ATPase activity
A616_RS24975	COG1840	ABC-type Fe3 transport system, periplasmic component
A616_RS24995	COG0583	DNA-binding transcription factor activity
A616_RS25010	COG1414	Transcriptional regulator
A616_RS25015	COG0765	amino acid transport
A616_RS25020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A616_RS25055	COG0003	Pfam Anion-transporting ATPase
A616_RS25075	COG1215	transferase activity, transferring glycosyl groups
A616_RS25095	COG4129	membrane
A616_RS25105	COG3253	May function as heme-dependent peroxidase
A616_RS25110	COG0363	glucosamine-6-phosphate deaminase activity
A616_RS25115	COG1737	Transcriptional regulator
A616_RS25135	COG1012	belongs to the aldehyde dehydrogenase family
A616_RS25140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A616_RS25145	COG3938	Belongs to the proline racemase family
A616_RS25150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A616_RS25155	COG2204	response regulator
A616_RS25195	COG0776	regulation of translation
A616_RS25230	COG4166	transmembrane transport
A616_RS25235	COG0006	proline dipeptidase activity
A616_RS25280	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A616_RS25290	COG0656	L-ascorbic acid biosynthetic process
A616_RS25295	COG1733	regulation of RNA biosynthetic process
A616_RS25300	COG0667	Aldo Keto reductase
A616_RS25330	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A616_RS25335	COG0720	synthase
A616_RS25345	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A616_RS25380	COG0456	acetyltransferase
A616_RS25390	COG0681	Belongs to the peptidase S26 family
A616_RS25400	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A616_RS25405	COG4988	ABC transporter
A616_RS25410	COG1294	oxidase, subunit
A616_RS25415	COG1271	oxidase subunit
A616_RS25425	COG1191	sigma factor activity
A616_RS25435	COG1357	PFAM Pentapeptide repeats (8 copies)
A616_RS25440	COG0860	N-Acetylmuramoyl-L-alanine amidase
A616_RS25445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A616_RS25455	COG1607	acyl-coa hydrolase
A616_RS25475	COG0628	permease
A616_RS25480	COG2084	Dehydrogenase
A616_RS25485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A616_RS25495	COG2309	aminopeptidase activity
A616_RS25500	COG0745	RESPONSE REGULATOR receiver
A616_RS25505	COG5002	protein histidine kinase activity
A616_RS25510	COG1285	pathogenesis
A616_RS25520	COG0445	tRNA wobble uridine modification
A616_RS25525	COG0395	ABC-type sugar transport system, permease component
A616_RS25530	COG1175	transmembrane transport
A616_RS25545	COG2207	Transcriptional regulator
A616_RS25545	COG4753	response regulator
A616_RS25550	COG2972	Histidine kinase
A616_RS25570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A616_RS25575	COG0456	acetyltransferase
A616_RS25575	COG0454	-acetyltransferase
A616_RS25585	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A616_RS25595	COG4166	transmembrane transport
A616_RS25605	COG5583	Uncharacterized small protein (DUF2292)
A616_RS25610	COG4608	Belongs to the ABC transporter superfamily
A616_RS25615	COG0444	Belongs to the ABC transporter superfamily
A616_RS25625	COG0601	transmembrane transport
A616_RS25630	COG0747	negative chemotaxis
A616_RS25640	COG1309	transcriptional regulator
A616_RS25655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A616_RS25670	COG2909	trisaccharide binding
A616_RS25685	COG1846	Transcriptional regulator
A616_RS25695	COG2311	Membrane
A616_RS25760	COG2204	response regulator
A616_RS25765	COG3135	benzoate transporter
A616_RS25770	COG1028	Short-chain dehydrogenase reductase Sdr
A616_RS25780	COG0477	Major facilitator Superfamily
A616_RS25785	COG2207	Transcriptional regulator
A616_RS25795	COG0697	spore germination
A616_RS25810	COG0095	Lipoate-protein ligase
A616_RS25820	COG2205	protein histidine kinase activity
A616_RS25825	COG0745	RESPONSE REGULATOR receiver
A616_RS25830	COG0739	heme binding
A616_RS25840	COG0640	Transcriptional regulator
A616_RS25845	COG0697	spore germination
A616_RS25860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A616_RS25865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A616_RS25870	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A616_RS25875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A616_RS25880	COG0745	RESPONSE REGULATOR receiver
A616_RS25885	COG5002	protein histidine kinase activity
A616_RS25895	COG0596	Alpha beta hydrolase
A616_RS25900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A616_RS25905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A616_RS25910	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A616_RS25915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A616_RS25915	COG2207	Transcriptional regulator
A616_RS25920	COG0768	penicillin binding
A616_RS25925	COG0768	penicillin binding
A616_RS25935	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
A616_RS25980	COG1473	amidohydrolase
A616_RS25985	COG2271	Major facilitator Superfamily
A616_RS26005	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A616_RS26040	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A616_RS26045	COG1472	Belongs to the glycosyl hydrolase 3 family
A616_RS26055	COG0395	ABC-type sugar transport system, permease component
A616_RS26060	COG1175	transmembrane transport
A616_RS26070	COG1737	Transcriptional regulator
A616_RS26085	COG1028	Short-chain dehydrogenase reductase Sdr
A616_RS26125	COG0243	molybdopterin cofactor binding
A616_RS26135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A616_RS26140	COG2223	nitrite transmembrane transporter activity
A616_RS26145	COG1151	hydroxylamine reductase activity
A616_RS26160	COG1595	DNA-templated transcription, initiation
A616_RS26170	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
A616_RS26180	COG0531	amino acid
A616_RS26200	COG0840	transmembrane signaling receptor activity
A616_RS26220	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A616_RS26225	COG1832	CoA-binding protein
A616_RS26230	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A616_RS26240	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
A616_RS26250	COG3584	3D domain protein
A616_RS26270	COG1252	NADH dehydrogenase
A616_RS26325	COG0316	Belongs to the HesB IscA family
A616_RS26335	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A616_RS26345	COG1252	NADH dehydrogenase
A616_RS26350	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A616_RS26390	COG4837	Protein of unknown function (DUF1462)
A616_RS26395	COG0626	cystathionine gamma-synthase activity
A616_RS26400	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A616_RS26405	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A616_RS26415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A616_RS26425	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A616_RS26430	COG0647	UMP catabolic process
A616_RS26445	COG2445	Protein of unknown function DUF86
A616_RS26455	COG1494	fructose-1,6-bisphosphatase
A616_RS26470	COG4470	Protein conserved in bacteria
A616_RS26480	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A616_RS26490	COG0420	3'-5' exonuclease activity
A616_RS26495	COG0693	protein deglycase activity
A616_RS26500	COG0739	heme binding
A616_RS26530	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A616_RS26535	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A616_RS26535	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A616_RS26545	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A616_RS26545	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A616_RS26550	COG1011	Hydrolase
A616_RS26555	COG2329	Antibiotic biosynthesis monooxygenase
A616_RS26570	COG3258	Cytochrome c
A616_RS26575	COG2204	response regulator
A616_RS26580	COG3852	Histidine kinase
A616_RS26605	COG0840	transmembrane signaling receptor activity
A616_RS26615	COG0702	epimerase
A616_RS26620	COG0598	Magnesium transport protein CorA
A616_RS26635	COG3377	Domain of unknown function (DUF1805)
A616_RS26645	COG0737	Belongs to the 5'-nucleotidase family
A616_RS26650	COG0730	response to heat
A616_RS26655	COG1801	Protein of unknown function DUF72
A616_RS26665	COG0527	aspartate kinase activity
A616_RS26675	COG2268	Band 7 protein
A616_RS26685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A616_RS26760	COG0719	Fe-S assembly protein
A616_RS26765	COG0822	iron-sulfur transferase activity
A616_RS26770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A616_RS26775	COG0719	Fe-S assembly protein
A616_RS26780	COG0396	ATPase activity
A616_RS26785	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A616_RS26790	COG1473	amidohydrolase
A616_RS26810	COG0840	transmembrane signaling receptor activity
A616_RS26815	COG0509	glycine decarboxylation via glycine cleavage system
A616_RS26820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A616_RS26825	COG0436	Aminotransferase
A616_RS26830	COG1393	Belongs to the ArsC family
A616_RS26845	COG1126	abc transporter atp-binding protein
A616_RS26850	COG0616	signal peptide processing
A616_RS26860	COG2340	Cysteine-rich secretory protein family
A616_RS26865	COG0477	Major facilitator Superfamily
A616_RS26870	COG1132	(ABC) transporter
A616_RS26875	COG1132	(ABC) transporter
A616_RS26880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A616_RS26885	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A616_RS26890	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
A616_RS26905	COG1850	ribulose-bisphosphate carboxylase activity
A616_RS26910	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
A616_RS26915	COG0235	Class ii aldolase
A616_RS26920	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
A616_RS26935	COG0697	spore germination
A616_RS26955	COG1960	acyl-CoA dehydrogenase activity
A616_RS26960	COG0183	Belongs to the thiolase family
A616_RS26965	COG1250	3-hydroxyacyl-CoA dehydrogenase
A616_RS26965	COG1024	Enoyl-CoA hydratase
A616_RS26980	COG1131	(ABC) transporter
A616_RS27010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A616_RS27025	COG5577	PFAM Coat F domain
A616_RS27030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A616_RS27035	COG1279	arginine transmembrane transporter activity
A616_RS27040	COG1392	Phosphate transport regulator
A616_RS27045	COG0306	phosphate transporter
A616_RS27100	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A616_RS27105	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A616_RS27115	COG1376	ErfK ybiS ycfS ynhG family protein
A616_RS27145	COG1122	ATPase activity
A616_RS27155	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
A616_RS27160	COG0310	cobalt ion transport
A616_RS27165	COG0167	dihydroorotate dehydrogenase activity
A616_RS27185	COG0686	Belongs to the AlaDH PNT family
A616_RS27190	COG2508	Transcriptional regulator
A616_RS27190	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A616_RS27200	COG0477	Major facilitator Superfamily
A616_RS27210	COG2201	protein-glutamate methylesterase activity
A616_RS27220	COG1744	ABC transporter substrate-binding protein PnrA-like
A616_RS27225	COG3852	Histidine kinase
A616_RS27230	COG1506	peptidase
A616_RS27235	COG0583	DNA-binding transcription factor activity
A616_RS27245	COG1098	S1 RNA binding domain
A616_RS27270	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A616_RS27295	COG0788	formyltetrahydrofolate deformylase activity
A616_RS27300	COG1309	transcriptional regulator
A616_RS27305	COG0842	Transport permease protein
A616_RS27310	COG1131	(ABC) transporter
A616_RS27315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A616_RS27320	COG0346	lactoylglutathione lyase activity
A616_RS27325	COG0551	DNA topoisomerase type I activity
A616_RS27325	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A616_RS27330	COG0789	Transcriptional regulator
A616_RS27340	COG0477	Major facilitator Superfamily
A616_RS27355	COG0531	amino acid
A616_RS27360	COG2318	DinB family
A616_RS27370	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A616_RS27375	COG0419	ATPase involved in DNA repair
A616_RS27380	COG0420	3'-5' exonuclease activity
A616_RS27395	COG1612	heme a metabolic process
A616_RS27400	COG0109	protoheme IX farnesyltransferase activity
A616_RS27410	COG3336	cytochrome c oxidase
A616_RS27420	COG1012	belongs to the aldehyde dehydrogenase family
A616_RS27425	COG2151	metal-sulfur cluster biosynthetic enzyme
A616_RS27440	COG3396	Phenylacetate-CoA oxygenase
A616_RS27445	COG0840	transmembrane signaling receptor activity
A616_RS27455	COG0410	ABC transporter
A616_RS27485	COG0183	Belongs to the thiolase family
A616_RS27490	COG0183	Belongs to the thiolase family
A616_RS27495	COG1250	3-hydroxyacyl-CoA dehydrogenase
A616_RS27500	COG1250	3-hydroxyacyl-CoA dehydrogenase
A616_RS27505	COG1024	Enoyl-CoA hydratase
A616_RS27515	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A616_RS27520	COG1024	Enoyl-CoA hydratase
A616_RS27525	COG2050	protein possibly involved in aromatic compounds catabolism
A616_RS27530	COG2050	protein possibly involved in aromatic compounds catabolism
A616_RS27550	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A616_RS27565	COG2010	Cytochrome c
A616_RS27565	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A616_RS27570	COG1028	Short-chain dehydrogenase reductase Sdr
A616_RS27590	COG0697	spore germination
A616_RS27595	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A616_RS27605	COG1131	(ABC) transporter
A616_RS27615	COG0840	transmembrane signaling receptor activity
A616_RS27645	COG0714	Associated with various cellular activities
A616_RS27660	COG1131	(ABC) transporter
A616_RS27675	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
A616_RS27680	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A616_RS27685	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A616_RS27690	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A616_RS27700	COG2076	Multidrug Resistance protein
A616_RS27710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A616_RS27730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A616_RS27765	COG3359	exonuclease
A616_RS27770	COG1111	helicase
A616_RS27770	COG1205	dead DEAH box helicase
A616_RS27800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A616_RS27815	COG1175	transmembrane transport
A616_RS27825	COG3842	ATPase activity
A616_RS27830	COG3226	Transcriptional regulator
A616_RS27845	COG2140	Oxalate decarboxylase
A616_RS27850	COG0584	glycerophosphoryl diester phosphodiesterase
A616_RS27855	COG2814	Major facilitator Superfamily
A616_RS27875	COG2255	four-way junction helicase activity
A616_RS27890	COG2304	oxidoreductase activity
A616_RS27895	COG0586	Pfam SNARE associated Golgi protein
A616_RS27900	COG2207	Transcriptional regulator
A616_RS27905	COG0154	amidase activity
A616_RS27925	COG4175	Glycine betaine
A616_RS27925	COG0517	IMP dehydrogenase activity
A616_RS27935	COG1510	regulation of RNA biosynthetic process
A616_RS27950	COG4895	conserved protein (DUF2196)
A616_RS27965	COG0745	RESPONSE REGULATOR receiver
A616_RS27970	COG5002	protein histidine kinase activity
A616_RS27990	COG4191	Histidine kinase
A616_RS28000	COG0457	Tetratricopeptide repeat
A616_RS28000	COG0463	Glycosyl transferase, family 2
A616_RS28005	COG0463	Glycosyl transferase, family 2
A616_RS28020	COG3409	Peptidoglycan-binding domain 1 protein
A616_RS28020	COG5632	N-Acetylmuramoyl-L-alanine amidase
A616_RS28115	COG3677	Transposase
A616_RS28140	COG0519	Catalyzes the synthesis of GMP from XMP
A616_RS28145	COG0024	Methionine aminopeptidase
A616_RS28170	COG5002	protein histidine kinase activity
A616_RS28170	COG3850	Histidine kinase
A616_RS28175	COG0745	RESPONSE REGULATOR receiver
A616_RS28180	COG0471	metal ion transport
A616_RS28185	COG1929	Belongs to the glycerate kinase type-1 family
A616_RS28190	COG4214	carbohydrate transport
A616_RS28195	COG1129	ABC transporter
A616_RS28205	COG4191	Histidine kinase
A616_RS28220	COG1595	DNA-templated transcription, initiation
A616_RS28235	COG1414	Transcriptional regulator
A616_RS28245	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A616_RS28245	COG1918	ferrous iron import across plasma membrane
A616_RS28250	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A616_RS28255	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A616_RS28265	COG1595	DNA-templated transcription, initiation
A616_RS28305	COG4166	transmembrane transport
A616_RS28345	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A616_RS28350	COG0747	negative chemotaxis
A616_RS28370	COG4608	Belongs to the ABC transporter superfamily
A616_RS28375	COG0444	Belongs to the ABC transporter superfamily
A616_RS28380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A616_RS28385	COG0601	transmembrane transport
A616_RS28390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A616_RS28445	COG1595	DNA-templated transcription, initiation
A616_RS28455	COG1733	regulation of RNA biosynthetic process
A616_RS28460	COG0778	Nitroreductase
A616_RS28495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A616_RS28510	COG1999	signal sequence binding
A616_RS28520	COG0109	protoheme IX farnesyltransferase activity
A616_RS28525	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A616_RS28535	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A616_RS28540	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A616_RS28545	COG0697	spore germination
A616_RS28560	COG2313	pseudouridylate synthase activity
A616_RS28565	COG1982	Orn Lys Arg decarboxylase major
A616_RS28570	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A616_RS28575	COG0477	Major facilitator Superfamily
A616_RS28605	COG4608	Belongs to the ABC transporter superfamily
A616_RS28610	COG0444	Belongs to the ABC transporter superfamily
A616_RS28615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A616_RS28620	COG0601	transmembrane transport
A616_RS28640	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A616_RS28645	COG0165	Argininosuccinate lyase
A616_RS28665	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A616_RS28680	COG0544	peptidyl-prolyl cis-trans isomerase activity
A616_RS28690	COG5002	protein histidine kinase activity
A616_RS28695	COG0745	RESPONSE REGULATOR receiver
A616_RS28720	COG3706	GGDEF domain
A616_RS28730	COG1114	Component of the transport system for branched-chain amino acids
A616_RS28795	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A616_RS28840	COG2801	Transposase and inactivated derivatives
A616_RS28860	COG0017	Asparaginyl-tRNA synthetase
A616_RS28880	COG0318	PFAM AMP-dependent synthetase and ligase
A616_RS28910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A616_RS28935	COG1131	(ABC) transporter
A616_RS28965	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A616_RS28970	COG0557	exoribonuclease II activity
A616_RS28975	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A616_RS28985	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A616_RS28990	COG0390	transport system, permease component
A616_RS29005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A616_RS29010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A616_RS29015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A616_RS29020	COG1120	ATPase activity
A616_RS29025	COG0148	phosphopyruvate hydratase activity
A616_RS29030	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A616_RS29035	COG0149	triose-phosphate isomerase activity
A616_RS29040	COG0126	phosphoglycerate kinase activity
A616_RS29045	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A616_RS29050	COG1757	Na H antiporter
A616_RS29065	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A616_RS29075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A616_RS29080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A616_RS29085	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A616_RS29090	COG4191	Histidine kinase
A616_RS29130	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A616_RS29135	COG1481	regulation of sporulation
A616_RS29140	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A616_RS29145	COG1660	Displays ATPase and GTPase activities
A616_RS29150	COG0492	ferredoxin-NADP+ reductase activity
A616_RS29195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A616_RS29200	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A616_RS29200	COG0140	phosphoribosyl-ATP diphosphatase activity
A616_RS29205	COG0107	imidazoleglycerol-phosphate synthase activity
A616_RS29210	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A616_RS29215	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A616_RS29220	COG0131	Imidazoleglycerol-phosphate dehydratase
A616_RS29225	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A616_RS29230	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A616_RS29235	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A616_RS29240	COG0110	maltose O-acetyltransferase activity
A616_RS29245	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A616_RS29250	COG1950	PFAM Membrane protein of
A616_RS29255	COG1418	mRNA catabolic process
A616_RS29260	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A616_RS29265	COG0556	nucleotide-excision repair
A616_RS29285	COG3409	Peptidoglycan-binding domain 1 protein
A616_RS29285	COG0793	Belongs to the peptidase S41A family
A616_RS29290	COG0739	heme binding
A616_RS29295	COG2177	Part of the ABC transporter FtsEX involved in
A616_RS29300	COG2884	Cell division ATP-binding protein ftsE
A616_RS29305	COG1979	alcohol dehydrogenase
A616_RS29310	COG0531	amino acid
A616_RS29320	COG0165	Argininosuccinate lyase
A616_RS29325	COG0137	argininosuccinate synthase activity
A616_RS29335	COG2199	diguanylate cyclase activity
A616_RS29335	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A616_RS29345	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A616_RS29355	COG0505	Belongs to the CarA family
A616_RS29360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A616_RS29365	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A616_RS29370	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A616_RS29385	COG5002	protein histidine kinase activity
A616_RS29400	COG0653	protein targeting
A616_RS29405	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A616_RS29415	COG1278	Cold shock
A616_RS29420	COG0765	amino acid transport
A616_RS29450	COG1516	flagellar protein fliS
A616_RS29455	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A616_RS29460	COG1334	flagellar protein FlaG
A616_RS29465	COG1083	cytidylyl-transferase
A616_RS29490	COG2089	acid synthase
A616_RS29495	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A616_RS29500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A616_RS29500	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A616_RS29505	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A616_RS29510	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A616_RS29515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A616_RS29530	COG1045	serine acetyltransferase
A616_RS29540	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A616_RS29545	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A616_RS29550	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A616_RS29555	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A616_RS29560	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
A616_RS29570	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A616_RS29575	COG4786	Flagellar basal body rod
A616_RS29575	COG1256	bacterial-type flagellum assembly
A616_RS29600	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A616_RS29610	COG2197	response regulator
A616_RS29620	COG0726	polysaccharide deacetylase
A616_RS29620	COG1649	PFAM Uncharacterised BCR, COG1649
A616_RS29625	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A616_RS29630	COG1404	Belongs to the peptidase S8 family
A616_RS29650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A616_RS29655	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A616_RS29665	COG0438	transferase activity, transferring glycosyl groups
A616_RS29675	COG0367	asparagine synthase
A616_RS29680	COG0367	asparagine synthase
A616_RS29695	COG0438	transferase activity, transferring glycosyl groups
A616_RS29740	COG0544	peptidyl-prolyl cis-trans isomerase activity
A616_RS29745	COG2373	Large extracellular alpha-helical protein
A616_RS29755	COG1739	Uncharacterized protein family UPF0029
A616_RS29765	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A616_RS29770	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A616_RS29775	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A616_RS29795	COG4786	Flagellar basal body rod
A616_RS29805	COG1609	Transcriptional regulator
A616_RS29810	COG0739	heme binding
A616_RS29815	COG2385	sporulation resulting in formation of a cellular spore
A616_RS29820	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A616_RS29835	COG1007	ATP synthesis coupled electron transport
A616_RS29840	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A616_RS29845	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A616_RS29850	COG0713	ATP synthesis coupled electron transport
A616_RS29860	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A616_RS29865	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A616_RS29870	COG0649	NAD binding
A616_RS29875	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A616_RS29880	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A616_RS29885	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A616_RS29895	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A616_RS29900	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A616_RS29905	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A616_RS29910	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A616_RS29915	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A616_RS29920	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A616_RS29930	COG0356	it plays a direct role in the translocation of protons across the membrane
A616_RS29945	COG0183	Belongs to the thiolase family
A616_RS29950	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A616_RS29950	COG2207	Transcriptional regulator
A616_RS29955	COG4106	trans-aconitate 2-methyltransferase activity
A616_RS29960	COG0596	Alpha beta hydrolase
A616_RS29965	COG0156	8-amino-7-oxononanoate synthase activity
A616_RS29970	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A616_RS29980	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A616_RS29985	COG1361	Conserved repeat domain
A616_RS29990	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A616_RS29995	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A616_RS30005	COG4475	Protein of unknown function (DUF436)
A616_RS30010	COG0698	ribose 5-phosphate isomerase
A616_RS30025	COG0009	L-threonylcarbamoyladenylate synthase
A616_RS30040	COG2890	protein-(glutamine-N5) methyltransferase activity
A616_RS30045	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A616_RS30055	COG1435	thymidine kinase activity
A616_RS30060	COG0415	Belongs to the DNA photolyase family
A616_RS30065	COG0254	rRNA binding
A616_RS30075	COG0739	heme binding
A616_RS30080	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A616_RS30085	COG1494	fructose-1,6-bisphosphatase
A616_RS30090	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A616_RS30095	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A616_RS30100	COG0191	fructose-bisphosphate aldolase activity
A616_RS30105	COG2204	response regulator
A616_RS30115	COG0504	CTP synthase activity
A616_RS30120	COG3343	RNA polymerase activity
A616_RS30145	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A616_RS30145	COG1703	isobutyryl-CoA mutase activity
A616_RS30145	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A616_RS30150	COG1309	transcriptional regulator
A616_RS30155	COG1960	acyl-CoA dehydrogenase activity
A616_RS30160	COG1960	acyl-CoA dehydrogenase activity
A616_RS30165	COG1250	3-hydroxyacyl-CoA dehydrogenase
A616_RS30170	COG0183	Belongs to the thiolase family
A616_RS30180	COG1595	DNA-templated transcription, initiation
A616_RS30185	COG2181	nitrate reductase activity
A616_RS30185	COG0247	lactate metabolic process
A616_RS30190	COG1509	lysine 2,3-aminomutase activity
A616_RS30195	COG3829	transcription factor binding
A616_RS30215	COG0010	Belongs to the arginase family
A616_RS30220	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A616_RS30225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A616_RS30265	COG3465	dGTPase activity
A616_RS30270	COG1078	dGTPase activity
A616_RS30290	COG1309	transcriptional regulator
A616_RS30295	COG1664	Polymer-forming cytoskeletal
A616_RS30300	COG0789	Transcriptional regulator
A616_RS30310	COG0564	pseudouridine synthase activity
A616_RS30340	COG0116	Belongs to the methyltransferase superfamily
A616_RS30345	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A616_RS30365	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A616_RS30380	COG2329	Antibiotic biosynthesis monooxygenase
A616_RS30385	COG2204	response regulator
A616_RS30390	COG0626	cystathionine gamma-synthase activity
A616_RS30410	COG2267	carboxylic ester hydrolase activity
A616_RS30420	COG1122	ATPase activity
A616_RS30425	COG1122	ATPase activity
A616_RS30445	COG0531	amino acid
A616_RS30450	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A616_RS30460	COG0405	Gamma-glutamyltransferase
A616_RS30470	COG0584	glycerophosphoryl diester phosphodiesterase
A616_RS30475	COG1653	transport
A616_RS30480	COG0395	ABC-type sugar transport system, permease component
A616_RS30485	COG1175	transmembrane transport
A616_RS30490	COG3842	ATPase activity
A616_RS30495	COG0546	phosphoglycolate phosphatase activity
A616_RS30505	COG0659	secondary active sulfate transmembrane transporter activity
A616_RS30520	COG0813	purine-nucleoside phosphorylase activity
A616_RS30525	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A616_RS30530	COG1079	Belongs to the binding-protein-dependent transport system permease family
A616_RS30535	COG4603	Belongs to the binding-protein-dependent transport system permease family
A616_RS30540	COG3845	ABC transporter
A616_RS30550	COG0840	transmembrane signaling receptor activity
A616_RS30565	COG1846	Transcriptional regulator
A616_RS30595	COG0833	amino acid
A616_RS30605	COG1414	Transcriptional regulator
A616_RS30610	COG4187	Peptidase family M20/M25/M40
A616_RS30615	COG1765	OsmC-like protein
A616_RS30620	COG2207	Transcriptional regulator
A616_RS30625	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A616_RS30630	COG2233	PERMEase
A616_RS30640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A616_RS30645	COG2309	aminopeptidase activity
A616_RS30700	COG0039	L-malate dehydrogenase activity
A616_RS30705	COG4302	ethanolamine ammonia-lyase activity
A616_RS30710	COG4303	Ethanolamine ammonia lyase large subunit
A616_RS30730	COG1160	GTP binding
A616_RS30740	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
A616_RS30750	COG4869	propanediol catabolic process
A616_RS30760	COG1012	belongs to the aldehyde dehydrogenase family
A616_RS30760	COG1454	alcohol dehydrogenase
A616_RS30765	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
A616_RS30780	COG0745	RESPONSE REGULATOR receiver
A616_RS30785	COG5002	protein histidine kinase activity
A616_RS30800	COG3119	arylsulfatase activity
A616_RS30805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A616_RS30815	COG0246	Mannitol dehydrogenase
A616_RS30820	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A616_RS30825	COG3711	transcriptional antiterminator
A616_RS30840	COG0513	Belongs to the DEAD box helicase family
A616_RS30850	COG0840	transmembrane signaling receptor activity
A616_RS30855	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A616_RS30885	COG0860	N-Acetylmuramoyl-L-alanine amidase
A616_RS30900	COG0860	N-Acetylmuramoyl-L-alanine amidase
A616_RS30915	COG0277	FAD linked oxidase domain protein
A616_RS30920	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A616_RS30920	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A616_RS30925	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A616_RS30930	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A616_RS30935	COG1028	Short-chain dehydrogenase reductase Sdr
A616_RS30940	COG1012	belongs to the aldehyde dehydrogenase family
A616_RS30945	COG0473	3-isopropylmalate dehydrogenase activity
A616_RS30950	COG3284	Transcriptional regulator
A616_RS30955	COG1012	belongs to the aldehyde dehydrogenase family
A616_RS30970	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A616_RS30980	COG2205	protein histidine kinase activity
A616_RS30985	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A616_RS30990	COG0561	phosphatase activity
A616_RS30995	COG1486	melibiose metabolic process
A616_RS31000	COG1447	Phosphotransferase system cellobiose-specific component IIA
A616_RS31005	COG3394	polysaccharide catabolic process
A616_RS31020	COG3933	PFAM sigma-54 factor interaction domain-containing protein
A616_RS31020	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A616_RS31025	COG0745	RESPONSE REGULATOR receiver
A616_RS31025	COG4191	Histidine kinase
A616_RS31025	COG2205	protein histidine kinase activity
A616_RS31050	COG0514	ATP-dependent DNA helicase (RecQ)
A616_RS31095	COG1285	pathogenesis
A616_RS31100	COG0534	Mate efflux family protein
A616_RS31105	COG3397	chitin binding
A616_RS31110	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A616_RS31115	COG3842	ATPase activity
A616_RS31120	COG1177	transmembrane transport
A616_RS31125	COG1176	ABC-type spermidine putrescine transport system, permease component I
A616_RS31155	COG2011	ABC-type metal ion transport system permease component
A616_RS31170	COG1120	ATPase activity
A616_RS31180	COG4607	ABC-type enterochelin transport system periplasmic component
A616_RS31185	COG4604	ABC transporter, ATP-binding protein
A616_RS31190	COG4605	iron ion homeostasis
A616_RS31195	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A616_RS31215	COG2201	protein-glutamate methylesterase activity
A616_RS31230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A616_RS31280	COG1280	lysine exporter protein (LysE YggA)
A616_RS31310	COG1649	PFAM Uncharacterised BCR, COG1649
A616_RS31315	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A616_RS31335	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
A616_RS31345	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
A616_RS31355	COG0395	ABC-type sugar transport system, permease component
A616_RS31360	COG1175	transmembrane transport
A616_RS31370	COG3842	ATPase activity
A616_RS31375	COG0584	glycerophosphoryl diester phosphodiesterase
A616_RS31385	COG2822	iron ion transport
A616_RS31390	COG2837	iron assimilation
A616_RS31395	COG0672	)-iron permease
A616_RS31400	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A616_RS31405	COG2076	Multidrug Resistance protein
A616_RS31425	COG1968	undecaprenyl-diphosphatase activity
A616_RS31455	COG0726	polysaccharide deacetylase
A616_RS31460	COG1012	belongs to the aldehyde dehydrogenase family
A616_RS31465	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A616_RS31470	COG2204	response regulator
A616_RS31480	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A616_RS31490	COG0739	heme binding
A616_RS31500	COG2162	N-hydroxyarylamine O-acetyltransferase activity
A616_RS31505	COG3829	transcription factor binding
A616_RS31510	COG1028	Short-chain dehydrogenase reductase Sdr
A616_RS31515	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A616_RS31520	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A616_RS31530	COG1846	Transcriptional regulator
A616_RS31570	COG2076	Multidrug Resistance protein
A616_RS31585	COG3842	ATPase activity
A616_RS31590	COG1840	ABC-type Fe3 transport system, periplasmic component
A616_RS31600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A616_RS31605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A616_RS31610	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A616_RS31615	COG0463	Glycosyl transferase, family 2
A616_RS31615	COG0457	Tetratricopeptide repeat
A616_RS31620	COG2226	methyltransferase
A616_RS31665	COG0457	Tetratricopeptide repeat
A616_RS31665	COG0463	Glycosyl transferase, family 2
A616_RS31675	COG2824	Alkylphosphonate utilization operon protein PhnA
A616_RS31680	COG2197	response regulator
A616_RS31695	COG0577	efflux transmembrane transporter activity
A616_RS31700	COG1136	(ABC) transporter
A616_RS31720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A616_RS31725	COG0765	amino acid transport
A616_RS31730	COG1126	abc transporter atp-binding protein
A616_RS31770	COG0395	ABC-type sugar transport system, permease component
A616_RS31775	COG1175	transmembrane transport
A616_RS31780	COG2182	Extracellular solute-binding protein
A616_RS31785	COG2207	Transcriptional regulator
A616_RS31785	COG4753	response regulator
A616_RS31790	COG2972	Histidine kinase
A616_RS31795	COG3250	beta-galactosidase activity
A616_RS31800	COG1940	carbohydrate kinase activity
A616_RS31810	COG2222	sugar isomerase
A616_RS31825	COG0583	DNA-binding transcription factor activity
A616_RS31830	COG0693	protein deglycase activity
A616_RS31840	COG2197	response regulator
A616_RS31855	COG2814	Major facilitator Superfamily
A616_RS31875	COG0346	lactoylglutathione lyase activity
A616_RS31885	COG0431	NADPH-dependent FMN reductase
A616_RS31895	COG2214	Heat shock protein DnaJ domain protein
A616_RS31905	COG1309	transcriptional regulator
A616_RS31920	COG1090	epimerase
A616_RS31965	COG1404	Belongs to the peptidase S8 family
A616_RS31970	COG0579	oxidoreductase
A616_RS31990	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A616_RS31995	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A616_RS32000	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A616_RS32005	COG0277	FAD linked oxidase domain protein
A616_RS32045	COG0662	Cupin 2, conserved barrel domain protein
A616_RS32050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A616_RS32055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A616_RS32055	COG2207	Transcriptional regulator
A616_RS32060	COG1733	regulation of RNA biosynthetic process
A616_RS32065	COG0604	alcohol dehydrogenase
A616_RS32080	COG2378	regulation of single-species biofilm formation
A616_RS32085	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A616_RS32095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A616_RS32105	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A616_RS32110	COG4853	Protein conserved in bacteria
A616_RS32120	COG5002	protein histidine kinase activity
A616_RS32125	COG0745	RESPONSE REGULATOR receiver
A616_RS32135	COG0741	lytic transglycosylase activity
A616_RS32135	COG1196	nuclear chromosome segregation
A616_RS32135	COG0739	heme binding
A616_RS32150	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A616_RS32155	COG0305	Participates in initiation and elongation during chromosome replication
A616_RS32160	COG0359	binds to the 23S rRNA
A616_RS32165	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
A616_RS32175	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A616_RS32180	COG0629	single-stranded DNA binding
A616_RS32185	COG0360	Binds together with S18 to 16S ribosomal RNA
A616_RS32190	COG0012	GTP binding
A616_RS32195	COG0702	epimerase
A616_RS32200	COG1164	Oligoendopeptidase f
A616_RS32215	COG4481	Protein conserved in bacteria
A616_RS32220	COG0668	transmembrane transport
A616_RS32235	COG1597	lipid kinase activity
A616_RS32250	COG1475	DNA binding
A616_RS32255	COG1192	Involved in chromosome partitioning
A616_RS32260	COG1475	DNA binding
A616_RS32270	COG1285	pathogenesis
A616_RS32275	COG0357	Ribosomal RNA small subunit methyltransferase G
A616_RS32285	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A616_RS32290	COG1847	R3H domain protein
A616_RS32295	COG0706	membrane insertase activity
A616_RS32300	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A616_RS32305	COG0594	ribonuclease P activity
A616_RS32315	COG0230	Belongs to the bacterial ribosomal protein bL34 family