locus-tag class description GOP56_RS00005 ENOG41068P3 sporulation protein YqfC GOP56_RS00015 ENOG4105C9A Phoh family GOP56_RS00020 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GOP56_RS00025 ENOG4107YR5 Diacylglycerol kinase GOP56_RS00030 ENOG4105KG3 cytidine deaminase GOP56_RS00035 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GOP56_RS00045 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) GOP56_RS00055 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) GOP56_RS00060 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GOP56_RS00065 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GOP56_RS00075 ENOG4105C1G acyl-Coa dehydrogenase GOP56_RS00085 ENOG4105EGD dinuclear metal center protein, YbgI family GOP56_RS00160 ENOG4105N5T Radical SAM Protein GOP56_RS00170 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GOP56_RS00175 ENOG4108TSC N-acetyltransferase GOP56_RS00185 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GOP56_RS00200 ENOG4107S4Y M20 DapE family protein YgeY GOP56_RS00220 ENOG4108XG4 DNA-binding transcriptional regulator GOP56_RS00225 ENOG4107KET secretion protein, HlyD family GOP56_RS00240 ENOG4105DYS nad(p)h dehydrogenase (quinone) GOP56_RS00270 ENOG4105DWF phosphomethylpyrimidine kinase GOP56_RS00295 ENOG4105ZMH deoxynucleoside kinase GOP56_RS00315 ENOG4108S4H thioesterase Superfamily protein GOP56_RS00330 ENOG4105C84 Histidine ammonia-lyase GOP56_RS00340 ENOG4105E5J UV damage endonuclease GOP56_RS00370 ENOG4106678 morphogenetic protein associated with SpoVID GOP56_RS00375 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GOP56_RS00400 ENOG4108Z0R Transferase GOP56_RS00405 ENOG4105D9U N-acetyltransferase GOP56_RS00415 ENOG4105CAQ asparagine synthetase GOP56_RS00420 ENOG4105BZU Histidine kinase GOP56_RS00425 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GOP56_RS00435 ENOG4105C75 arginyL-tRNA synthetase GOP56_RS00475 ENOG4108QTI )-transporter GOP56_RS00480 ENOG4108PCN EamA-like transporter family GOP56_RS00485 ENOG4105CTD carboxy-peptidase GOP56_RS00495 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) GOP56_RS00515 ENOG4108JJB ABC transporter GOP56_RS00520 ENOG4108JJB ABC transporter GOP56_RS00540 ENOG4105KHC sulfurtransferase GOP56_RS00545 ENOG4107YBY Hydrolase GOP56_RS00575 ENOG4108INS Transcriptional regulator GOP56_RS00585 ENOG4107SDU Methyl-accepting chemotaxis GOP56_RS00590 ENOG4105F27 Major Facilitator GOP56_RS00595 ENOG4105WAB arsR family transcriptional regulator GOP56_RS00600 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component GOP56_RS00610 ENOG4105D2X ABC transporter substrate-binding protein GOP56_RS00615 ENOG4108C33 Resolvase GOP56_RS00635 ENOG41082YX Transcriptional regulator, arsr family GOP56_RS00640 ENOG4105D6J arsenicaL-resistance protein GOP56_RS00660 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GOP56_RS00670 ENOG4107RT3 EamA-like transporter family GOP56_RS00675 ENOG4105GZI Transcriptional regulator GOP56_RS00705 ENOG4107XJU UPF0178 protein GOP56_RS00710 ENOG410841Q phosphoesterase PA-phosphatase related protein GOP56_RS00780 ENOG4105ZPI UPF0358 protein GOP56_RS00785 ENOG4105UPD Calcium Proton GOP56_RS00800 ENOG4108ZSR alkaline shock protein GOP56_RS00805 ENOG4105CNI cell division protein FtsW GOP56_RS00815 ENOG41080XQ Signal transduction protein with cbs domains GOP56_RS00855 ENOG4105E7W lamb ycsf family protein GOP56_RS00870 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GOP56_RS00895 ENOG4105C0D helicase GOP56_RS00900 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GOP56_RS00905 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GOP56_RS00910 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GOP56_RS00915 ENOG4105C8Q Methyl-accepting chemotaxis GOP56_RS00920 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) GOP56_RS00960 ENOG4108QY0 Membrane GOP56_RS00970 ENOG4105DQ5 transport system permease protein GOP56_RS00975 ENOG4105EHG Permease protein GOP56_RS00980 ENOG410874W AraC family transcriptional regulator GOP56_RS00990 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GOP56_RS01015 ENOG4105DM4 PTS System GOP56_RS01020 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GOP56_RS01025 ENOG4105BZU Histidine kinase GOP56_RS01050 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GOP56_RS01055 ENOG4106F5Q Membrane GOP56_RS01060 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein GOP56_RS01075 ENOG4105C59 p-type ATPase GOP56_RS01080 ENOG4105C4M (Ubiquinol oxidase) subunit I GOP56_RS01085 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GOP56_RS01090 ENOG4108JJ9 ABC, transporter GOP56_RS01095 ENOG4108JJ8 (ABC) transporter GOP56_RS01100 ENOG4108Q5U germination protein, ger(x)c family GOP56_RS01115 ENOG4105PGM cation diffusion facilitator family transporter GOP56_RS01145 ENOG4107RHR regulatoR GOP56_RS01155 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GOP56_RS01165 ENOG4107YFT Nadph-dependent fmn reductase GOP56_RS01170 ENOG4105KST dependent repressor GOP56_RS01185 ENOG4105CBJ Metal-dependent enzyme GOP56_RS01195 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GOP56_RS01200 ENOG4105DC7 peptidase M24 GOP56_RS01205 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GOP56_RS01215 ENOG4105EMN RNA polymerase sigma factor GOP56_RS01225 ENOG4108VMM UPF0756 membrane protein GOP56_RS01230 ENOG4108N5B 2-phosphosulfolactate phosphatase GOP56_RS01235 ENOG41061P3 phosphosulfolactate synthase GOP56_RS01250 ENOG4105CD2 stage iii sporulation protein aa GOP56_RS01255 ENOG4105KR5 Stage iii sporulation protein GOP56_RS01260 ENOG4108CQH stage III sporulation protein AC GOP56_RS01265 ENOG4105KQ4 Stage iii sporulation protein ad GOP56_RS01275 ENOG410644B Stage III sporulation protein af GOP56_RS01295 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GOP56_RS01300 ENOG4108ZSR alkaline shock protein GOP56_RS01315 ENOG4105M7K Involved in the transcription termination process (By similarity) GOP56_RS01320 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GOP56_RS01325 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GOP56_RS01330 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GOP56_RS01335 ENOG41084DP Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GOP56_RS01345 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GOP56_RS01350 ENOG4105DX0 Hemolysin A GOP56_RS01360 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GOP56_RS01365 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) GOP56_RS01370 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GOP56_RS01455 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GOP56_RS01475 ENOG4108151 Beta-lactamase domain protein GOP56_RS01480 ENOG4107QKG PfaD family GOP56_RS01485 ENOG41062T2 Acyl carrier protein GOP56_RS01490 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase GOP56_RS01495 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase GOP56_RS01500 ENOG4108MGH Enoyl-CoA hydratase GOP56_RS01510 ENOG4105DDN Pentapeptide repeat-containing protein GOP56_RS01515 ENOG4107SQU synthase GOP56_RS01520 ENOG4105C0W non-ribosomal peptide synthetase GOP56_RS01525 ENOG4105C0W non-ribosomal peptide synthetase GOP56_RS01535 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase GOP56_RS01570 ENOG4105S1Z Stage IV sporulation protein B GOP56_RS01575 ENOG4107QQR Sporulation GOP56_RS01585 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GOP56_RS01590 ENOG4105KXX peptidase s58 dmpa GOP56_RS01605 ENOG4105KT7 mgtC SapB transporter GOP56_RS01610 ENOG4105C31 Tryptophanyl-tRNA synthetase GOP56_RS01625 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GOP56_RS01640 ENOG4105EXC Acyl-transferase GOP56_RS01645 ENOG4105CW7 secretion protein, HlyD family GOP56_RS01650 ENOG4105C19 ABC transporter GOP56_RS01655 ENOG4107RBB ABC transporter, permease GOP56_RS01665 ENOG4105JVQ RNA Polymerase GOP56_RS01690 ENOG4105CKK Glycosyl transferase, family 2 GOP56_RS01705 ENOG4108JUB Transcriptional regulator GOP56_RS01725 ENOG4105CPP Dehydrogenase, E1 component GOP56_RS01730 ENOG4105C7S Dehydrogenase GOP56_RS01745 ENOG4108ZVT methylmalonyl-coA epimerase GOP56_RS01750 ENOG4108HNZ carboxyl transferase GOP56_RS01755 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GOP56_RS01770 ENOG4108YZ4 nudix hydrolase GOP56_RS01780 ENOG4105MZ9 stage II sporulation protein m GOP56_RS01785 ENOG4105I3K Ferric uptake regulator, Fur family GOP56_RS01795 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GOP56_RS01800 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) GOP56_RS01820 ENOG4108HM4 ABC transporter GOP56_RS01830 ENOG4105F38 ABC transporter, permease GOP56_RS01835 ENOG4105D38 putrescine abc transporter GOP56_RS01840 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GOP56_RS01850 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GOP56_RS01855 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GOP56_RS01865 ENOG4108JQ7 (ABC) transporter GOP56_RS01870 ENOG4105C8Q Methyl-accepting chemotaxis GOP56_RS01875 ENOG4105DZ1 carboxypeptidase GOP56_RS01880 ENOG41082AN stage II sporulation protein GOP56_RS01885 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) GOP56_RS01890 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GOP56_RS01905 ENOG41090VF Stage v sporulation protein ac GOP56_RS01910 ENOG4105CZ3 stage V sporulation protein ad GOP56_RS01920 ENOG4105G6R Stage v sporulation protein ae GOP56_RS01930 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GOP56_RS01935 ENOG4107ZE5 PPIases accelerate the folding of proteins GOP56_RS02020 ENOG4105FQP Beta-lactamase GOP56_RS02025 ENOG41067TZ transcriptional regulator, MarR family GOP56_RS02060 ENOG4105IBP Cyclic peptide transporter GOP56_RS02070 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GOP56_RS02075 ENOG4108Z4T Peptidase M50 GOP56_RS02080 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) GOP56_RS02085 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) GOP56_RS02090 ENOG4105DZ1 carboxypeptidase GOP56_RS02095 ENOG4108JIC nucleoside recognition domain protein GOP56_RS02105 ENOG4105FE9 pseudouridine synthase GOP56_RS02110 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GOP56_RS02115 ENOG4107TWT Cytochrome c biogenesis protein GOP56_RS02120 ENOG4105CRE cytochrome C GOP56_RS02125 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GOP56_RS02130 ENOG4105BZU Histidine kinase GOP56_RS02155 ENOG4108JQ1 Dehydrogenase GOP56_RS02180 ENOG4105C9U ATP-dependent DNA helicase RecQ GOP56_RS02185 ENOG4105I7S Abortive infection protein GOP56_RS02195 ENOG4105CAY ferredoxin--nadp reductase GOP56_RS02200 ENOG4108S6Z Negative regulator of genetic competence GOP56_RS02205 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) GOP56_RS02215 ENOG4105HDK L-asparaginase GOP56_RS02230 ENOG4105MSI germination protein ypeb GOP56_RS02245 ENOG4105CAT Cytidine monophosphate kinase GOP56_RS02255 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GOP56_RS02265 ENOG4105S2F GOP56_RS02275 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GOP56_RS02280 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GOP56_RS02285 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GOP56_RS02320 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) GOP56_RS02330 ENOG4105EUJ GTP cyclohydrolase i GOP56_RS02355 ENOG4105E4C Lytic transglycosylase catalytic GOP56_RS02360 ENOG4105WP2 Tryptophan RNA-binding attenuator protein GOP56_RS02370 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) GOP56_RS02375 ENOG4105DT3 PTS system, galactitol-specific IIc component GOP56_RS02380 ENOG4105CTS PTS system mannitol-specific GOP56_RS02385 ENOG4107RUY (E1 component), alpha subunit GOP56_RS02390 ENOG4105CPP Dehydrogenase, E1 component GOP56_RS02405 ENOG4105DKT Transcriptional regulator GOP56_RS02420 ENOG4105XXQ heptaprenyl diphosphate synthase component I GOP56_RS02430 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GOP56_RS02435 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GOP56_RS02445 ENOG4105EAH synthase GOP56_RS02450 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GOP56_RS02455 ENOG4105BZU Histidine kinase GOP56_RS02460 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GOP56_RS02465 ENOG4105D49 3-dehydroquinate synthase GOP56_RS02470 ENOG4105KHN chorismate mutase GOP56_RS02480 ENOG4108I0Q anthranilate phosphoribosyltransferase GOP56_RS02485 ENOG4105DK0 Indole-3-glycerol phosphate synthase GOP56_RS02490 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase GOP56_RS02495 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GOP56_RS02500 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) GOP56_RS02505 ENOG4105CIH Imidazole acetol-phosphate transaminase GOP56_RS02515 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GOP56_RS02530 ENOG4105EMN RNA polymerase sigma factor GOP56_RS02560 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) GOP56_RS02565 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GOP56_RS02570 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit GOP56_RS02585 ENOG4108JYZ YitT family GOP56_RS02590 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase GOP56_RS02595 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GOP56_RS02600 ENOG4108Z5K methylglyoxal synthase GOP56_RS02605 ENOG4105FJR Lmbe family GOP56_RS02610 ENOG4105CPK Glycosyl transferase (Group 1 GOP56_RS02620 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase GOP56_RS02625 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GOP56_RS02630 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GOP56_RS02635 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) GOP56_RS02645 ENOG4105DVT helicase GOP56_RS02655 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) GOP56_RS02660 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GOP56_RS02700 ENOG4105CHM Aminotransferase GOP56_RS02705 ENOG4105C5S asparaginyl-tRNA synthetase GOP56_RS02710 ENOG4105DHS permease protein GOP56_RS02715 ENOG4105CM4 permease protein GOP56_RS02720 ENOG4108IPW abc transporter atp-binding protein GOP56_RS02740 ENOG4107SBE Glycosyl transferase (Group 1 GOP56_RS02755 ENOG4108IAJ Nad-dependent epimerase dehydratase GOP56_RS02760 ENOG4107T8Q Glycosyl transferase (Group 1 GOP56_RS02765 ENOG4105C6Y Udp-glucose 6-dehydrogenase GOP56_RS02770 ENOG4105DPN Oligoendopeptidase f GOP56_RS02775 ENOG4105CE4 GlcNAc 6-P deacetylase GOP56_RS02785 ENOG4105ENT Efflux transporter rnd family, mfp subunit GOP56_RS02795 ENOG4105W8Z 4'-phosphopantetheinyl transferase GOP56_RS02800 ENOG4105CB2 alcohol dehydrogenase GOP56_RS02810 ENOG4105CEY Amp-dependent synthetase and ligase GOP56_RS02815 ENOG4108Z40 Transcriptional regulator GOP56_RS02820 ENOG4107ZXU DSBA oxidoreductase GOP56_RS02840 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GOP56_RS02845 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GOP56_RS02850 ENOG4105C5Q Transcriptional regulator GOP56_RS02855 ENOG4105SZ6 Thioredoxin GOP56_RS02860 ENOG4107VXM glycerophosphoryl diester phosphodiesterase GOP56_RS02865 ENOG4108YBP pseudouridine synthase GOP56_RS02875 ENOG4108IPJ Membrane GOP56_RS02945 ENOG4105CHH sulfate transporter GOP56_RS02985 ENOG4107QJT sodium dicarboxylate symporter GOP56_RS03015 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GOP56_RS03020 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GOP56_RS03025 ENOG4108MRH transcriptional regulatory protein GOP56_RS03050 ENOG4105CEY Amp-dependent synthetase and ligase GOP56_RS03055 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GOP56_RS03060 ENOG4105CAQ asparagine synthetase GOP56_RS03065 ENOG4107QKG PfaD family GOP56_RS03070 ENOG4105C0W non-ribosomal peptide synthetase GOP56_RS03075 ENOG4105C0W non-ribosomal peptide synthetase GOP56_RS03075 ENOG4105C0W non-ribosomal peptide synthetase GOP56_RS03080 ENOG4105C0W non-ribosomal peptide synthetase GOP56_RS03085 ENOG4105C0W non-ribosomal peptide synthetase GOP56_RS03095 ENOG4105C84 Histidine ammonia-lyase GOP56_RS03100 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily GOP56_RS03110 ENOG410787A Pts system, glucitol sorbitol-specific GOP56_RS03115 ENOG4105DZY Pts system, glucitol sorbitol-specific GOP56_RS03155 ENOG4105KNA -acetyltransferase GOP56_RS03160 ENOG4105E0Y RtcB Protein GOP56_RS03165 ENOG4108DBC nitroreductase GOP56_RS03170 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GOP56_RS03175 ENOG4105ERH Fumarylacetoacetate hydrolase GOP56_RS03195 ENOG4105I03 Flagellin GOP56_RS03200 ENOG4105I03 Flagellin GOP56_RS03205 ENOG4105I03 Flagellin GOP56_RS03215 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GOP56_RS03255 ENOG41069ER domain protein GOP56_RS03390 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GOP56_RS03450 ENOG4105XRQ Xanthine dehydrogenase accessory factor GOP56_RS03470 ENOG41087PP glycosyltransferase MGT family GOP56_RS03480 ENOG4108S3Y transcriptional regulator GOP56_RS03485 ENOG4105CS2 ec 3.2.1.21 GOP56_RS03505 ENOG41088SP formiminoglutamate hydrolase GOP56_RS03510 ENOG4105D6U Sodium Glutamate Symporter GOP56_RS03540 ENOG4108V5C ABC transporter GOP56_RS03550 ENOG410756H nucleotidyltransferase GOP56_RS03555 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GOP56_RS03575 ENOG4105U6W MutT NUDIX family protein GOP56_RS03585 ENOG4105C4X radical SAM domain protein GOP56_RS03595 ENOG4108VW9 Membrane GOP56_RS03605 ENOG4105CK1 PTS System GOP56_RS03615 ENOG4105CS2 ec 3.2.1.21 GOP56_RS03620 ENOG4105CS2 ec 3.2.1.21 GOP56_RS03625 ENOG4105CNG UPF0061 protein GOP56_RS03635 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) GOP56_RS03670 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) GOP56_RS03675 ENOG4105CIH Imidazole acetol-phosphate transaminase GOP56_RS03680 ENOG4108YZT Adenosylcobinamide kinase GOP56_RS03685 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) GOP56_RS03700 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) GOP56_RS03710 ENOG4108IJ0 Aspartate ammonia-lyase GOP56_RS03715 ENOG4105DZ1 carboxypeptidase GOP56_RS03725 ENOG4108RE9 Phosphodiesterase GOP56_RS03730 ENOG4105WAB arsR family transcriptional regulator GOP56_RS03735 ENOG4105DEN Luciferase family GOP56_RS03740 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GOP56_RS03750 ENOG4108UZ3 Transporter GOP56_RS03755 ENOG4105D03 DNA-3-methyladenine glycosylase II GOP56_RS03765 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GOP56_RS03785 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GOP56_RS03810 ENOG4105PFC Transcriptional regulator GOP56_RS03855 ENOG4107RA1 nh(3)-dependent nad( ) synthetase GOP56_RS03860 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GOP56_RS03865 ENOG4105DAP Nicotinate phosphoribosyltransferase GOP56_RS03880 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase GOP56_RS03885 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GOP56_RS03890 ENOG4108R6K riboflavin synthase, subunit alpha GOP56_RS03895 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GOP56_RS03900 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GOP56_RS03910 ENOG4108151 Beta-lactamase domain protein GOP56_RS03915 ENOG4107QKG PfaD family GOP56_RS03920 ENOG4105C0W non-ribosomal peptide synthetase GOP56_RS03925 ENOG4105C0W non-ribosomal peptide synthetase GOP56_RS03930 ENOG4107SQU synthase GOP56_RS03990 ENOG4107SQU synthase GOP56_RS03995 ENOG4105C0W non-ribosomal peptide synthetase GOP56_RS04000 ENOG4105C0W non-ribosomal peptide synthetase GOP56_RS04005 ENOG41062T2 Acyl carrier protein GOP56_RS04010 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase GOP56_RS04015 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase GOP56_RS04020 ENOG4108MGH Enoyl-CoA hydratase GOP56_RS04025 ENOG4108KQ6 Enoyl-CoA hydratase GOP56_RS04055 ENOG4108JCI Transcriptional regulator GOP56_RS04065 ENOG4108S3A nucleotidyltransferase GOP56_RS04070 ENOG4105ID8 Transcriptional regulator, ARAC family GOP56_RS04080 ENOG4105CMT Dihydroxyacetone kinase GOP56_RS04095 ENOG410874W AraC family transcriptional regulator GOP56_RS04120 ENOG4105CE7 Amidase, hydantoinase carbamoylase family GOP56_RS04125 ENOG4105DJB Major Facilitator Superfamily GOP56_RS04130 ENOG4105S0E allantoin catabolism protein GOP56_RS04135 ENOG4105DG4 malate L-lactate dehydrogenase GOP56_RS04140 ENOG4105DG4 malate L-lactate dehydrogenase GOP56_RS04145 ENOG4107R1Q Membrane protein FdrA GOP56_RS04150 ENOG4107REC cytoplasmic protein GOP56_RS04160 ENOG4105C5B carbamate kinase GOP56_RS04165 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GOP56_RS04170 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) GOP56_RS04245 ENOG4105D4D transcriptional regulator GOP56_RS04250 ENOG4107Y2X deaminase GOP56_RS04265 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GOP56_RS04275 ENOG4107SNB ankyrin repeat protein YahD GOP56_RS04290 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GOP56_RS04295 ENOG4105BZU Histidine kinase GOP56_RS04305 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GOP56_RS04310 ENOG4107RBB ABC transporter, permease GOP56_RS04330 ENOG4105DRR Transcriptional regulator, GntR family GOP56_RS04340 ENOG4107S9D Alpha beta hydrolase GOP56_RS04395 ENOG4108RCF TRANSCRIPTIONal GOP56_RS04400 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein GOP56_RS04415 ENOG4105EMN RNA polymerase sigma factor GOP56_RS04425 ENOG4107STQ Multicopper oxidase GOP56_RS04450 ENOG4108UMN azlc family GOP56_RS04455 ENOG4108NGU Transcriptional regulator GOP56_RS04470 ENOG4105EWU Squalene--hopene cyclase GOP56_RS04485 ENOG4105IJJ transcriptional regulator, crp fnr family GOP56_RS04490 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) GOP56_RS04500 ENOG4105CEY Amp-dependent synthetase and ligase GOP56_RS04540 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein GOP56_RS04545 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GOP56_RS04570 ENOG41089UC methyltransferase, type 11 GOP56_RS04575 ENOG4108UXE Protein tyrosine phosphatase GOP56_RS04580 ENOG4105D6J arsenicaL-resistance protein GOP56_RS04615 ENOG4105E8G Major facilitator Superfamily GOP56_RS04660 ENOG41082F9 transcriptional regulator GOP56_RS04670 ENOG4105VMP Transcriptional regulator GOP56_RS04680 ENOG4105BZ1 (ABC) transporter GOP56_RS04685 ENOG4105BZ1 (ABC) transporter GOP56_RS04705 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GOP56_RS04710 ENOG4105KBX Transcriptional regulator, TetR family GOP56_RS04715 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GOP56_RS04720 ENOG4105RJZ Transcriptional regulator GOP56_RS04725 ENOG4105MHT Transcriptional regulator, ARSR family GOP56_RS04750 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GOP56_RS04790 ENOG4105EHG Permease protein GOP56_RS04795 ENOG4105DQ5 transport system permease protein GOP56_RS04800 ENOG4105BZ1 (ABC) transporter GOP56_RS04805 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GOP56_RS04820 ENOG4105WEF catalase GOP56_RS04825 ENOG4105DEF Extracellular solute-binding protein, family 5 GOP56_RS04835 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GOP56_RS04840 ENOG4105C3U ABC transporter GOP56_RS04845 ENOG4108JQ7 (ABC) transporter GOP56_RS04850 ENOG4105IBP Cyclic peptide transporter GOP56_RS04895 ENOG4105K63 Thioredoxin GOP56_RS04910 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family GOP56_RS04915 ENOG4105C5X domain protein GOP56_RS04925 ENOG4105E4C Lytic transglycosylase catalytic GOP56_RS04945 ENOG4105E1K spore germination protein GOP56_RS04955 ENOG4108KPJ rna polymerase sigma factor GOP56_RS04960 ENOG4105C09 Bile acid GOP56_RS04965 ENOG4105DRR Transcriptional regulator, GntR family GOP56_RS04970 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GOP56_RS04975 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GOP56_RS04980 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) GOP56_RS04985 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) GOP56_RS04990 ENOG4105C5H ABC transporter GOP56_RS04995 ENOG4105EU9 GOP56_RS05015 ENOG410605W Major Facilitator GOP56_RS05020 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) GOP56_RS05070 ENOG4105BZU Histidine kinase GOP56_RS05075 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GOP56_RS05080 ENOG4107R16 Multicopper oxidase GOP56_RS05085 ENOG4105CUB amino acid GOP56_RS05115 ENOG4105CEY Amp-dependent synthetase and ligase GOP56_RS05195 ENOG4105NDK ethanolamine utilization protein GOP56_RS05200 ENOG4105ENY Ethanolamine utilization protein eutH GOP56_RS05220 ENOG4105KNY Microcompartments protein GOP56_RS05225 ENOG4105C0A alcohol dehydrogenase GOP56_RS05230 ENOG4105KNY Microcompartments protein GOP56_RS05235 ENOG4106D67 ethanolamine utilization protein GOP56_RS05240 ENOG4107FQ9 ethanolamine ammonia-lyase GOP56_RS05245 ENOG4105CPD ethanolamine ammonia-lyase GOP56_RS05250 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase GOP56_RS05255 ENOG4105KTW ethanolamine utilization protein GOP56_RS05260 ENOG4105M3W utilization protein GOP56_RS05270 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GOP56_RS05350 ENOG4108JB9 formate dehydrogenase GOP56_RS05375 ENOG4105BZ1 (ABC) transporter GOP56_RS05380 ENOG4105BZ1 (ABC) transporter GOP56_RS05390 ENOG4107X2U Inherit from COG: Exonuclease-like protein GOP56_RS05395 ENOG4108I5C dEAD DEAH box helicase GOP56_RS05400 ENOG4108Z40 Transcriptional regulator GOP56_RS05405 ENOG4105CJ3 phosphate transporter GOP56_RS05410 ENOG4107GRR phosphate transport regulator GOP56_RS05415 ENOG4105MKU Transcriptional regulator GOP56_RS05425 ENOG4107VFM Dehydrogenase GOP56_RS05440 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GOP56_RS05445 ENOG41061AI Protein of unknown function (DUF2905) GOP56_RS05450 ENOG4106YBV Methyl-accepting chemotaxis GOP56_RS05475 ENOG41061ZR Transcriptional regulator GOP56_RS05490 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) GOP56_RS05500 ENOG4105C37 (CBS) domain GOP56_RS05510 ENOG4107AYK membrAne GOP56_RS05515 ENOG4105DVH amino acid GOP56_RS05520 ENOG4107V2S Transcriptional regulator GOP56_RS05530 ENOG4108VXD carboxy-peptidase GOP56_RS05535 ENOG4105D82 Glutamate dehydrogenase GOP56_RS05540 ENOG4107YU2 histidine triad (hIT) protein GOP56_RS05560 ENOG4105E98 transcriptional regulator DeoR family GOP56_RS05590 ENOG4105E0A ABC, transporter GOP56_RS05595 ENOG4105EHG Permease protein GOP56_RS05600 ENOG4108QY0 Membrane GOP56_RS05605 ENOG41090VF Stage v sporulation protein ac GOP56_RS05610 ENOG4105CZ3 stage V sporulation protein ad GOP56_RS05635 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein GOP56_RS05655 ENOG4105C0D helicase GOP56_RS05660 ENOG4105QEK Transcriptional regulator GOP56_RS05665 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) GOP56_RS05675 ENOG4105D2M Aldolase GOP56_RS05680 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GOP56_RS05690 ENOG4107ZXU DSBA oxidoreductase GOP56_RS05695 ENOG4105CEY Amp-dependent synthetase and ligase GOP56_RS05715 ENOG4108B31 Spore germination protein GOP56_RS05720 ENOG4105E1K spore germination protein GOP56_RS05765 ENOG4108JPW Aminotransferase GOP56_RS05770 ENOG4105C0W non-ribosomal peptide synthetase GOP56_RS05790 ENOG4105CHR reductase GOP56_RS05800 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GOP56_RS05805 ENOG4108Z7G MaoC domain protein dehydratase GOP56_RS05810 ENOG4105CEY Amp-dependent synthetase and ligase GOP56_RS05840 ENOG4108IMY Transcriptional regulator GOP56_RS05845 ENOG4105DC7 peptidase M24 GOP56_RS05850 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GOP56_RS05855 ENOG4105CMV Succinyl-CoA synthetase subunit beta GOP56_RS05860 ENOG4105C7S Dehydrogenase GOP56_RS05865 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GOP56_RS05870 ENOG4107QPK )-transporter GOP56_RS05875 ENOG4105NDK ethanolamine utilization protein GOP56_RS05880 ENOG4105ENY Ethanolamine utilization protein eutH GOP56_RS05890 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml GOP56_RS05900 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) GOP56_RS05910 ENOG4105KNY Microcompartments protein GOP56_RS05915 ENOG4105C0A alcohol dehydrogenase GOP56_RS05920 ENOG4105KNY Microcompartments protein GOP56_RS05925 ENOG4106D67 ethanolamine utilization protein GOP56_RS05935 ENOG4105CPD ethanolamine ammonia-lyase GOP56_RS05940 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase GOP56_RS05960 ENOG4105M3W utilization protein GOP56_RS05980 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase GOP56_RS05985 ENOG4105DKW ABC transporter GOP56_RS06050 ENOG41069H0 dihydroorotase EC 3.5.2.3 GOP56_RS06055 ENOG4105ETD TRANSCRIPTIONal GOP56_RS06065 ENOG4105EEM helicase GOP56_RS06085 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GOP56_RS06095 ENOG4107V6Q Cyclic nucleotide-binding domain GOP56_RS06100 ENOG4105DQQ Major facilitator superfamily MFS_1 GOP56_RS06115 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GOP56_RS06120 ENOG4105C0R drug resistance transporter emrb qaca subfamily GOP56_RS06125 ENOG4105VRS hydrolase family 18 GOP56_RS06140 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GOP56_RS06145 ENOG4105GR3 Histidine kinase GOP56_RS06155 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GOP56_RS06165 ENOG4105PXI polysaccharide deacetylase GOP56_RS06170 ENOG4105D17 glycoside hydrolase, family 3 domain protein GOP56_RS06175 ENOG4105EHZ conserved protein UCP016719 GOP56_RS06180 ENOG4108J8C transporter major facilitator family protein GOP56_RS06185 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase GOP56_RS06200 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase GOP56_RS06220 ENOG4105D3A purine nucleoside phosphorylase DeoD-type GOP56_RS06225 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GOP56_RS06230 ENOG4105BZU Histidine kinase GOP56_RS06255 ENOG4107RMD Basic membrane lipoprotein GOP56_RS06260 ENOG4105BZU Histidine kinase GOP56_RS06265 ENOG4105DAP Nicotinate phosphoribosyltransferase GOP56_RS06290 ENOG4105E8R UPF0173 metal-dependent hydrolase GOP56_RS06295 ENOG4105E0M Sulfatase GOP56_RS06310 ENOG4107Y7Q pfkb domain protein GOP56_RS06320 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GOP56_RS06335 ENOG4107SN7 NLP P60 protein GOP56_RS06340 ENOG4105DTQ mandelate racemase muconate lactonizing GOP56_RS06345 ENOG4105CNN ABC, transporter GOP56_RS06350 ENOG4105C2J ABC transporter GOP56_RS06365 ENOG4108JJB ABC transporter GOP56_RS06370 ENOG4105C7J ABC transporter, permease GOP56_RS06400 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GOP56_RS06405 ENOG4105D5Q Arginine ornithine antiporter GOP56_RS06415 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GOP56_RS06420 ENOG41069B3 Small, acid-soluble spore protein Tlp GOP56_RS06430 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GOP56_RS06435 ENOG4105KME endoribonuclease L-psp GOP56_RS06440 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase GOP56_RS06450 ENOG4105CEM UPF0597 protein GOP56_RS06465 ENOG4108K2B transcriptional regulator GOP56_RS06470 ENOG4105CAY ferredoxin--nadp reductase GOP56_RS06475 ENOG4105BZ1 (ABC) transporter GOP56_RS06480 ENOG4105EHG Permease protein GOP56_RS06485 ENOG4105DQ5 transport system permease protein GOP56_RS06495 ENOG4105C26 Dehydrogenase GOP56_RS06500 ENOG4105W8Z 4'-phosphopantetheinyl transferase GOP56_RS06510 ENOG4105C0D helicase GOP56_RS06515 ENOG4105C5H ABC transporter GOP56_RS06520 ENOG4107RQ2 Cytochrome c oxidase, subunit I GOP56_RS06525 ENOG4105NAA Cytochrome C oxidase, subunit II GOP56_RS06575 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GOP56_RS06580 ENOG4107TVC Glycosyl transferase, family 2 GOP56_RS06590 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GOP56_RS06595 ENOG4107QIV Cytochrome c biogenesis protein GOP56_RS06600 ENOG4105MIR Phenylalanine 4-monooxygenase GOP56_RS06620 ENOG4105ETU transcriptional activator (TenA GOP56_RS06625 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GOP56_RS06630 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GOP56_RS06635 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GOP56_RS06640 ENOG4108VEU Thiamine monophosphate synthase GOP56_RS06655 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GOP56_RS06660 ENOG4107RA1 nh(3)-dependent nad( ) synthetase GOP56_RS06665 ENOG4105DF9 Lipoate-protein, ligase GOP56_RS06670 ENOG4105DUM transcriptional regulator, lysR family GOP56_RS06715 ENOG4105D3Y Na H antiporter GOP56_RS06730 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GOP56_RS06745 ENOG41065KQ synthase GOP56_RS06755 ENOG4106F1P AAA ATPase, central domain protein GOP56_RS06775 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GOP56_RS06780 ENOG4105CDY transcriptional regulatory protein GOP56_RS06805 ENOG4105CJ1 ABC, transporter GOP56_RS06825 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) GOP56_RS06830 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) GOP56_RS06835 ENOG4108JQ7 (ABC) transporter GOP56_RS06840 ENOG4105C3U ABC transporter GOP56_RS06845 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GOP56_RS06850 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GOP56_RS06855 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein GOP56_RS06860 ENOG4108TVJ Nitroreductase GOP56_RS06865 ENOG4108VGI doxx family GOP56_RS06870 ENOG41090MY MarR family Transcriptional regulator GOP56_RS06875 ENOG4105I03 Flagellin GOP56_RS06880 ENOG4105I03 Flagellin GOP56_RS06885 ENOG4105I03 Flagellin GOP56_RS06890 ENOG4105I03 Flagellin GOP56_RS06910 ENOG4105I03 Flagellin GOP56_RS06925 ENOG4105I03 Flagellin GOP56_RS06975 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) GOP56_RS06990 ENOG4108VMM UPF0756 membrane protein GOP56_RS07000 ENOG4108NKM UPF0354 protein GOP56_RS07005 ENOG4108R1P GOP56_RS07020 ENOG4105KJF protein tyrosine phosphatase GOP56_RS07040 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) GOP56_RS07050 ENOG4105C7S Dehydrogenase GOP56_RS07055 ENOG4105CPP Dehydrogenase, E1 component GOP56_RS07085 ENOG4108YX9 iron--sulfur cluster insertion protein erpA GOP56_RS07095 ENOG4105EEM helicase GOP56_RS07130 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GOP56_RS07210 ENOG4108BME Bacterial protein of unknown function (DUF896) GOP56_RS07220 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GOP56_RS07225 ENOG4105SXS Protein of unknown function (DUF456) GOP56_RS07245 ENOG4105DQ4 alcohol dehydrogenase GOP56_RS07270 ENOG4105CFF transcriptional regulator GOP56_RS07320 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein GOP56_RS07330 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GOP56_RS07335 ENOG4105BZU Histidine kinase GOP56_RS07340 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GOP56_RS07395 ENOG4108W0I acetyltransferase GOP56_RS07425 ENOG4105DIN metallophosphoesterase GOP56_RS07455 ENOG4105US7 Histidine kinase GOP56_RS07460 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GOP56_RS07475 ENOG4105E0A ABC, transporter GOP56_RS07480 ENOG4105EHG Permease protein GOP56_RS07505 ENOG4105FEA Spore maturation protein GOP56_RS07525 ENOG4106UW1 Major Facilitator superfamily GOP56_RS07535 ENOG4108UW5 maltose o-acetyltransferase GOP56_RS07540 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) GOP56_RS07550 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) GOP56_RS07555 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GOP56_RS07570 ENOG4105DEF Extracellular solute-binding protein, family 5 GOP56_RS07580 ENOG4105C5H ABC transporter GOP56_RS07645 ENOG4105JAB phenazine biosynthesis protein, phzf family GOP56_RS07650 ENOG4107U9B transcriptional regulator GOP56_RS07665 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GOP56_RS07675 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily GOP56_RS07690 ENOG4105BZ1 (ABC) transporter GOP56_RS07695 ENOG4105C2J ABC transporter GOP56_RS07730 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GOP56_RS07825 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) GOP56_RS07830 ENOG4105C5F glutamine synthetase GOP56_RS07835 ENOG4105KV4 Transcriptional regulator GOP56_RS07840 ENOG4107RF6 penicillin-binding protein GOP56_RS07845 ENOG4105CXI aluminum resistance protein GOP56_RS07850 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GOP56_RS07855 ENOG4106F1P AAA ATPase, central domain protein GOP56_RS07865 ENOG4108AEY RNA polymerase sigma factor GOP56_RS07870 ENOG4105W4W Transcriptional regulator GOP56_RS07880 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GOP56_RS07885 ENOG4105E98 transcriptional regulator DeoR family GOP56_RS07890 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GOP56_RS07895 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GOP56_RS07900 ENOG4107YX5 Pfam:DUF548 GOP56_RS07960 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GOP56_RS08010 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) GOP56_RS08015 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) GOP56_RS08035 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GOP56_RS08045 ENOG41067QW Transcriptional regulator GOP56_RS08065 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GOP56_RS08080 ENOG41080TC multidrug resistance protein GOP56_RS08085 ENOG4105F8D glycoside hydrolase family 4 GOP56_RS08090 ENOG4105VCP PTS System GOP56_RS08110 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GOP56_RS08115 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) GOP56_RS08135 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) GOP56_RS08155 ENOG4108RQ5 Beta-lactamase domain-containing protein GOP56_RS08160 ENOG4108K88 Membrane GOP56_RS08165 ENOG4105DQU oxidoreductase, subunit beta GOP56_RS08170 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein GOP56_RS08175 ENOG4105MCT stage V sporulation protein S GOP56_RS08180 ENOG4105D48 metallophosphoesterase GOP56_RS08195 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) GOP56_RS08200 ENOG4105C1J atp-dependent rna helicase GOP56_RS08210 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase GOP56_RS08215 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) GOP56_RS08230 ENOG4105XZV Protein of unknown function (DUF3243) GOP56_RS08235 ENOG4108RKS Short-chain dehydrogenase reductase Sdr GOP56_RS08260 ENOG4105UIB (ABC) transporter GOP56_RS08265 ENOG4108JQ9 ABC transporter GOP56_RS08270 ENOG4105DIH basic membrane GOP56_RS08275 ENOG4105CNU cell division protein FtsK GOP56_RS08285 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit GOP56_RS08300 ENOG41087PP glycosyltransferase MGT family GOP56_RS08315 ENOG4105CN5 Metallo-Beta-Lactamase GOP56_RS08320 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GOP56_RS08330 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GOP56_RS08335 ENOG4108S0H Dipicolinic acid synthetase, b subunit GOP56_RS08340 ENOG4105E35 Dipicolinate synthase subunit A GOP56_RS08355 ENOG4105C1V Peptidase, M16 GOP56_RS08365 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GOP56_RS08370 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GOP56_RS08375 ENOG4105DTN riboflavin biosynthesis protein ribF GOP56_RS08380 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GOP56_RS08385 ENOG4105SFS phosphoesterase RecJ domain protein GOP56_RS08390 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GOP56_RS08395 ENOG4105W7A Protein of unknown function (DUF503) GOP56_RS08410 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination GOP56_RS08415 ENOG4105CHV Transcription elongation factor NusA GOP56_RS08420 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) GOP56_RS08430 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GOP56_RS08435 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GOP56_RS08440 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GOP56_RS08445 ENOG4105DZP Membrane-associated zinc metalloprotease GOP56_RS08450 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GOP56_RS08455 ENOG4105KNE Phosphatidate cytidylyltransferase GOP56_RS08460 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GOP56_RS08465 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GOP56_RS08470 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GOP56_RS08475 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GOP56_RS08480 ENOG4105CE9 30S ribosomal protein S2 GOP56_RS08505 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GOP56_RS08515 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) GOP56_RS08525 ENOG4108V3W Chemotaxis protein, CheW GOP56_RS08530 ENOG4105CBS Chea signal transduction histidine kinase GOP56_RS08535 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) GOP56_RS08545 ENOG4105FZW flagellar biosynthesis regulator FlhF GOP56_RS08550 ENOG4105D7B Flagellar biosynthesis protein flha GOP56_RS08555 ENOG4105D00 flagellar biosynthetic protein flhB GOP56_RS08560 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GOP56_RS08565 ENOG4105VS8 Flagellar biosynthetic protein fliq GOP56_RS08570 ENOG4105CN7 Flagellar biosynthetic protein FliP GOP56_RS08580 ENOG4107YTP response regulator receiver protein GOP56_RS08585 ENOG4105DD5 Flagellar motor switch protein GOP56_RS08590 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GOP56_RS08600 ENOG41068WV flagellar FlbD family protein GOP56_RS08605 ENOG4108JQA flagellar GOP56_RS08640 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GOP56_RS08645 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) GOP56_RS08650 ENOG4105VQ0 flagellar hook-basal body complex protein fliE GOP56_RS08655 ENOG4108ZC9 flagellar basal-body rod protein flgc GOP56_RS08660 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GOP56_RS08665 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) GOP56_RS08675 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) GOP56_RS08680 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GOP56_RS08685 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) GOP56_RS08690 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GOP56_RS08695 ENOG4105C79 DNA protecting protein DprA GOP56_RS08700 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GOP56_RS08705 ENOG4105CMV Succinyl-CoA synthetase subunit beta GOP56_RS08725 ENOG4105C5H ABC transporter GOP56_RS08730 ENOG4105C0P Mg chelatase subunit ChlI GOP56_RS08735 ENOG4105KRN Transcriptional regulator, abrb family GOP56_RS08740 ENOG41080R2 UPF0102 protein GOP56_RS08745 ENOG4105VM1 flagellar GOP56_RS08755 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GOP56_RS08760 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) GOP56_RS08765 ENOG4105C3F Signal peptidase i GOP56_RS08770 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GOP56_RS08775 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GOP56_RS08780 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GOP56_RS08790 ENOG4105VB6 UPF0109 protein GOP56_RS08795 ENOG4105K5M 30s ribosomal protein S16 GOP56_RS08805 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) GOP56_RS08810 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GOP56_RS08815 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) GOP56_RS08820 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GOP56_RS08825 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GOP56_RS08830 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GOP56_RS08835 ENOG4105CHR reductase GOP56_RS08840 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GOP56_RS08850 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) GOP56_RS08855 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) GOP56_RS08860 ENOG41067VY 50S ribosomal protein L32 GOP56_RS08870 ENOG4105CDE UPF0348 protein GOP56_RS08875 ENOG41063PX domain protein GOP56_RS08880 ENOG4105D78 K07001 NTE family protein GOP56_RS08885 ENOG4105H20 Sporulation integral membrane protein YlbJ GOP56_RS08890 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GOP56_RS08895 ENOG4106H78 methyltransferase GOP56_RS08900 ENOG4105FDF Could be involved in DNA repair (By similarity) GOP56_RS08905 ENOG4108V06 Glutathione peroxidase GOP56_RS08925 ENOG4105DQE DNA ligase GOP56_RS08940 ENOG4105CJ3 phosphate transporter GOP56_RS08950 ENOG4105BZU Histidine kinase GOP56_RS08955 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) GOP56_RS08960 ENOG41082F9 transcriptional regulator GOP56_RS09025 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GOP56_RS09040 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GOP56_RS09050 ENOG4105CB5 ATP-dependent DNA helicase recG GOP56_RS09055 ENOG4105EJQ L-serine dehydratase GOP56_RS09075 ENOG4105E1K spore germination protein GOP56_RS09100 ENOG4105EPR degv family GOP56_RS09105 ENOG4105DP4 dak2 domain fusion protein ylov GOP56_RS09110 ENOG4108ZAA Alkaline-shock protein GOP56_RS09115 ENOG4105VB9 50S ribosomal protein l28 GOP56_RS09125 ENOG4105FJ0 thiamine GOP56_RS09130 ENOG4105CDA abc transporter atp-binding protein GOP56_RS09135 ENOG4105E5Q amino acid AbC transporter GOP56_RS09140 ENOG4108HW3 (ABC) transporter GOP56_RS09145 ENOG4105DJV ribulose-phosphate 3-epimerase GOP56_RS09150 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GOP56_RS09155 ENOG4105D9P serine threonine protein kinase GOP56_RS09160 ENOG4108ZF3 Phosphatase GOP56_RS09165 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GOP56_RS09170 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GOP56_RS09175 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GOP56_RS09180 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GOP56_RS09185 ENOG4105C25 Primosomal protein n' GOP56_RS09190 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GOP56_RS09210 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GOP56_RS09215 ENOG4105KC4 UPF0296 protein GOP56_RS09220 ENOG4105DSJ YicC domain protein GOP56_RS09270 ENOG4106YN8 Prenyltransferase GOP56_RS09275 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) GOP56_RS09300 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GOP56_RS09305 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GOP56_RS09310 ENOG4105CD3 dihydroorotase GOP56_RS09315 ENOG4105CXT aspartate transcarbamylase GOP56_RS09325 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) GOP56_RS09330 ENOG4105C34 Pseudouridine synthase GOP56_RS09335 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GOP56_RS09355 ENOG4108IQI permease GOP56_RS09370 ENOG4105CAY ferredoxin--nadp reductase GOP56_RS09385 ENOG4105CI2 imidazolone-5-propionate hydrolase GOP56_RS09400 ENOG4108JQ7 (ABC) transporter GOP56_RS09410 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GOP56_RS09415 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GOP56_RS09420 ENOG4107RCC Major Facilitator Superfamily GOP56_RS09425 ENOG4105DIA mandelate racemase muconate lactonizing GOP56_RS09435 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GOP56_RS09445 ENOG4105DBK s4 domain protein GOP56_RS09450 ENOG41067XK integral membrane protein GOP56_RS09455 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) GOP56_RS09460 ENOG4105DFA alanine racemase domain protein GOP56_RS09465 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GOP56_RS09470 ENOG4105WR5 sporulation protein, YlmC YmxH family GOP56_RS09480 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GOP56_RS09485 ENOG4108AWX Sporulation factor SpoIIGA GOP56_RS09490 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GOP56_RS09495 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GOP56_RS09500 ENOG4105K67 small basic protein GOP56_RS09515 ENOG41087KY Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) GOP56_RS09520 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GOP56_RS09525 ENOG4105D4A Cell wall formation (By similarity) GOP56_RS09530 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GOP56_RS09535 ENOG4105CNI cell division protein FtsW GOP56_RS09540 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GOP56_RS09545 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GOP56_RS09550 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GOP56_RS09555 ENOG4105CJN penicillin-binding protein GOP56_RS09560 ENOG4105CJN penicillin-binding protein GOP56_RS09570 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GOP56_RS09575 ENOG4108V6E Cell division protein mraZ GOP56_RS09580 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) GOP56_RS09595 ENOG41074B2 UPF0747 protein GOP56_RS09610 ENOG4107S3C Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GOP56_RS09620 ENOG4107QX3 carboxylase GOP56_RS09625 ENOG4105E39 Enoyl-CoA hydratase GOP56_RS09630 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GOP56_RS09635 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit GOP56_RS09640 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GOP56_RS09645 ENOG4108YG3 N-acetyltransferase GOP56_RS09650 ENOG4108VCI transcription factor, rsfa family GOP56_RS09690 ENOG4105C5X domain protein GOP56_RS09710 ENOG4108IAB Phoh family GOP56_RS09720 ENOG4105CPC Aldo Keto reductase GOP56_RS09765 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GOP56_RS09770 ENOG4105CI3 gtp-binding protein typa GOP56_RS09790 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) GOP56_RS09815 ENOG4105EA8 2-Nitropropane dioxygenase GOP56_RS09820 ENOG4105CXN decarboxylase GOP56_RS09860 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GOP56_RS09875 ENOG4105CH2 amidohydrolase GOP56_RS09880 ENOG4105C8Y Acetylornithine aminotransferase GOP56_RS09885 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) GOP56_RS09905 ENOG4105CDA abc transporter atp-binding protein GOP56_RS09910 ENOG4105DRP amino acid AbC transporter GOP56_RS09925 ENOG4105K8R UPF0145 protein GOP56_RS09950 ENOG4107TVC Glycosyl transferase, family 2 GOP56_RS09960 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase GOP56_RS09970 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase GOP56_RS09975 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) GOP56_RS10055 ENOG4105C7N Xanthine uracil vitamin C permease GOP56_RS10060 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase GOP56_RS10100 ENOG4108N2V aldose 1-epimerase GOP56_RS10130 ENOG4108R1E Serine threonine protein phosphatase 1 GOP56_RS10140 ENOG4105RD7 BadF BadG BcrA BcrD GOP56_RS10145 ENOG4106IQC argininosuccinate lyase GOP56_RS10150 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) GOP56_RS10155 ENOG4108I5D sulfate abc transporter GOP56_RS10170 ENOG4108W3Q Transcriptional regulator GOP56_RS10190 ENOG4105D29 Helix-turn-helix type 11 domain protein GOP56_RS10205 ENOG4108NGU Transcriptional regulator GOP56_RS10210 ENOG4105EXC Acyl-transferase GOP56_RS10360 ENOG41087BU transcriptional repressor DicA GOP56_RS10410 ENOG4105D0S secretion protein (HlyD GOP56_RS10420 ENOG41067TZ transcriptional regulator, MarR family GOP56_RS10425 ENOG4105BZU Histidine kinase GOP56_RS10430 ENOG4105WH1 Two component transcriptional regulator luxr family GOP56_RS10435 ENOG4105D94 Major Facilitator Superfamily GOP56_RS10440 ENOG4107RSM transcriptional regulator GOP56_RS10445 ENOG4105EMU Dehydrogenase GOP56_RS10490 ENOG4105CHM Aminotransferase GOP56_RS10500 ENOG4105CHR reductase GOP56_RS10530 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase GOP56_RS10540 ENOG4107QNK )-transporter GOP56_RS10555 ENOG41060D1 Quinol oxidase GOP56_RS10565 ENOG4105BZ9 Cytochrome C oxidase, subunit I GOP56_RS10575 ENOG4105CV8 reductase GOP56_RS10585 ENOG4105JAB phenazine biosynthesis protein, phzf family GOP56_RS10595 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GOP56_RS10600 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GOP56_RS10610 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator GOP56_RS10645 ENOG4105C5H ABC transporter GOP56_RS10660 ENOG4105NIV Esterase GOP56_RS10665 ENOG410874W AraC family transcriptional regulator GOP56_RS10690 ENOG4105DEG Vwa containing coxe family protein GOP56_RS10700 ENOG4105KKX ATPase associated with various cellular activities aaa_5 GOP56_RS10725 ENOG4105C0W non-ribosomal peptide synthetase GOP56_RS10740 ENOG4105C0W non-ribosomal peptide synthetase GOP56_RS10745 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase GOP56_RS10765 ENOG4108JJB ABC transporter GOP56_RS10775 ENOG4105BZ1 (ABC) transporter GOP56_RS10780 ENOG4105C8Q Methyl-accepting chemotaxis GOP56_RS10795 ENOG4105FR1 rard protein GOP56_RS10800 ENOG4105F0F Oxalate decarboxylase GOP56_RS10805 ENOG4105MIR Phenylalanine 4-monooxygenase GOP56_RS10815 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 GOP56_RS10850 ENOG4105EMN RNA polymerase sigma factor GOP56_RS10885 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GOP56_RS10895 ENOG4105NAE bifunctional deaminase-reductase domain protein GOP56_RS10900 ENOG4105D29 Helix-turn-helix type 11 domain protein GOP56_RS10955 ENOG4105KEG ribosomal-protein-alanine acetyltransferase GOP56_RS10960 ENOG41090UD (LipO)protein GOP56_RS10975 ENOG4105VTR Integrase GOP56_RS11000 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GOP56_RS11040 ENOG41066EA baseplate J family protein GOP56_RS11045 ENOG4105MFU Protein of unknown function (DUF2634) GOP56_RS11190 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) GOP56_RS11195 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) GOP56_RS11210 ENOG4107UBA reductase GOP56_RS11230 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) GOP56_RS11260 ENOG4105C2M dna polymerase I GOP56_RS11410 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GOP56_RS11425 ENOG4105C8Q Methyl-accepting chemotaxis GOP56_RS11440 ENOG4108W5N phosphatidylglycerophosphatase a GOP56_RS11450 ENOG4108ZMI UPF0477 protein GOP56_RS11455 ENOG4108HPG -acetyltransferase GOP56_RS11470 ENOG4105C37 (CBS) domain GOP56_RS11475 ENOG4105ENA helicase GOP56_RS11500 ENOG4108ZCF integral membrane protein GOP56_RS11515 ENOG4105YFD chemotaxis, protein GOP56_RS11525 ENOG41081HM 2'-5' rna ligase GOP56_RS11540 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) GOP56_RS11545 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) GOP56_RS11550 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GOP56_RS11555 ENOG4105C37 (CBS) domain GOP56_RS11580 ENOG4108TU7 Inherit from COG: (ABC) transporter GOP56_RS11585 ENOG4105CJ1 ABC, transporter GOP56_RS11590 ENOG41090WU lipolytic protein G-D-S-L family GOP56_RS11595 ENOG4105E5W Transporter GOP56_RS11600 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GOP56_RS11610 ENOG4105C8F Beta-lactamase domain protein GOP56_RS11620 ENOG4105KT7 mgtC SapB transporter GOP56_RS11630 ENOG4105RD7 BadF BadG BcrA BcrD GOP56_RS11640 ENOG4105VCP PTS System GOP56_RS11650 ENOG4105F8D glycoside hydrolase family 4 GOP56_RS11660 ENOG4105CK1 PTS System GOP56_RS11670 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GOP56_RS11685 ENOG4105DR5 peptidase GOP56_RS11690 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GOP56_RS11700 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GOP56_RS11705 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GOP56_RS11740 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GOP56_RS11745 ENOG4105BZW Glycerate kinase GOP56_RS11750 ENOG4107QQ0 gntp family GOP56_RS11755 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR GOP56_RS11765 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family GOP56_RS11770 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GOP56_RS11775 ENOG4105E0C molybdate abc transporter GOP56_RS11785 ENOG4105EQI Metal Dependent Phosphohydrolase GOP56_RS11795 ENOG4105DQR SNARE associated Golgi GOP56_RS11805 ENOG41067S9 phage shock protein C, PspC GOP56_RS11815 ENOG4105TRT Transcriptional regulator GOP56_RS11820 ENOG4108IJ7 Glycine betaine GOP56_RS11830 ENOG4107XWI flavin reductase domain protein, FMN-binding GOP56_RS11840 ENOG4105ERH Fumarylacetoacetate hydrolase GOP56_RS11850 ENOG4105EMS pseudouridine synthase GOP56_RS11860 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GOP56_RS11870 ENOG4108JQ7 (ABC) transporter GOP56_RS11875 ENOG4105C3U ABC transporter GOP56_RS11880 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) GOP56_RS11895 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) GOP56_RS11900 ENOG4105KBJ sporulation protein ytfj GOP56_RS11910 ENOG41069ER domain protein GOP56_RS11925 ENOG4108ZCF integral membrane protein GOP56_RS11930 ENOG4105BZU Histidine kinase GOP56_RS12025 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) GOP56_RS12035 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) GOP56_RS12040 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GOP56_RS12045 ENOG41063Y9 GOP56_RS12050 ENOG4108U5J '-nucleotidase GOP56_RS12080 ENOG4105EMU Dehydrogenase GOP56_RS12090 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) GOP56_RS12100 ENOG4108N23 SpoOM-related protein GOP56_RS12110 ENOG4105VV2 GOP56_RS12130 ENOG4105CBX hi0933 family GOP56_RS12140 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) GOP56_RS12145 ENOG4105U5Y Transcriptional regulator GOP56_RS12150 ENOG4105C5X domain protein GOP56_RS12155 ENOG4105BZU Histidine kinase GOP56_RS12160 ENOG4105CVJ phosphoglycerate mutase GOP56_RS12170 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GOP56_RS12175 ENOG4105BZ4 penicillin-binding protein GOP56_RS12180 ENOG4105F1V Acetoin utilization protein GOP56_RS12185 ENOG4105W87 Cbs domain GOP56_RS12190 ENOG4105DGU Histone deacetylase GOP56_RS12195 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase GOP56_RS12205 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) GOP56_RS12210 ENOG4105ETE Transcriptional regulator (LacI family GOP56_RS12215 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase GOP56_RS12220 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GOP56_RS12240 ENOG4105C88 aminopeptidase GOP56_RS12255 ENOG4105FGV Chromate GOP56_RS12260 ENOG4105CAH Chromate GOP56_RS12320 ENOG4105DU6 RNA polymerase GOP56_RS12330 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GOP56_RS12335 ENOG4108ZAF Molybdopterin GOP56_RS12340 ENOG4105D06 uba thif-type nad fad binding protein GOP56_RS12345 ENOG4107QM5 aconitate hydratase GOP56_RS12355 ENOG41069M3 Transcriptional regulator GOP56_RS12380 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GOP56_RS12385 ENOG4105ECY inositol monophosphatase GOP56_RS12395 ENOG4108IPJ Membrane GOP56_RS12405 ENOG4105C01 Dihydroxy-acid dehydratase GOP56_RS12410 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GOP56_RS12425 ENOG4105BZ4 penicillin-binding protein GOP56_RS12475 ENOG4105E0A ABC, transporter GOP56_RS12480 ENOG4108JYZ YitT family GOP56_RS12500 ENOG4105ECY inositol monophosphatase GOP56_RS12515 ENOG4105D22 carbon starvation protein GOP56_RS12520 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase GOP56_RS12525 ENOG4108D32 Methyltransferase GOP56_RS12535 ENOG4105C0R drug resistance transporter emrb qaca subfamily GOP56_RS12545 ENOG4105CW7 secretion protein, HlyD family GOP56_RS12550 ENOG41067TZ transcriptional regulator, MarR family GOP56_RS12565 ENOG4107QSE Dipeptidase GOP56_RS12575 ENOG4108EKC n-acetylglutamate synthase GOP56_RS12585 ENOG4105CPN adenine deaminase GOP56_RS12590 ENOG4105CFP Peptidase U32 GOP56_RS12600 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein GOP56_RS12605 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GOP56_RS12620 ENOG4105VEQ Cold shock protein GOP56_RS12625 ENOG410890F Dynamin family GOP56_RS12630 ENOG410890F Dynamin family GOP56_RS12670 ENOG4107Z3H Transcriptional regulator, TetR family GOP56_RS12675 ENOG4105CEY Amp-dependent synthetase and ligase GOP56_RS12690 ENOG4105BZU Histidine kinase GOP56_RS12695 ENOG4105BZU Histidine kinase GOP56_RS12715 ENOG4107BJW polysaccharide deacetylase GOP56_RS12720 ENOG4108QEG Membrane GOP56_RS12735 ENOG4108X4Q Hydrolase GOP56_RS12745 ENOG4105E98 transcriptional regulator DeoR family GOP56_RS12755 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) GOP56_RS12770 ENOG4106N3A copper homeostasis protein cutc GOP56_RS12780 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GOP56_RS12805 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GOP56_RS12810 ENOG4105CNN ABC, transporter GOP56_RS12815 ENOG4105C2J ABC transporter GOP56_RS12825 ENOG4108RVA ribokinase GOP56_RS12830 ENOG4105ETE Transcriptional regulator (LacI family GOP56_RS12840 ENOG4105CI2 imidazolone-5-propionate hydrolase GOP56_RS12845 ENOG4105CGP Urocanate hydratase GOP56_RS12850 ENOG4106R3P AraC family transcriptional regulator GOP56_RS12855 ENOG4108IJ0 Aspartate ammonia-lyase GOP56_RS12860 ENOG4107JTW chlorite dismutase GOP56_RS12865 ENOG4105CS9 pantothenic acid kinase GOP56_RS12875 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) GOP56_RS12880 ENOG4106K7D Major facilitator family transporter GOP56_RS12885 ENOG4105VCH membrane GOP56_RS12890 ENOG4105PNM synthesis protein GOP56_RS12925 ENOG41067QW Transcriptional regulator GOP56_RS12960 ENOG4105K4P CoA-binding domain protein GOP56_RS12965 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GOP56_RS12985 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GOP56_RS12990 ENOG41069ER domain protein GOP56_RS13005 ENOG41062IR nudix hydrolase GOP56_RS13015 ENOG4105CEP NADH dehydrogenase GOP56_RS13055 ENOG4108YX9 iron--sulfur cluster insertion protein erpA GOP56_RS13065 ENOG4105DVY radical SAM domain protein GOP56_RS13080 ENOG4105BZU Histidine kinase GOP56_RS13100 ENOG4105C28 cystathionine GOP56_RS13110 ENOG41083MR nifu domain-containing protein GOP56_RS13120 ENOG4105C5I Dehydrogenase GOP56_RS13130 ENOG4108W5N phosphatidylglycerophosphatase a GOP56_RS13135 ENOG4105D4U had-superfamily hydrolase, subfamily iia GOP56_RS13150 ENOG4105CBT Fructose-1,6-bisphosphatase GOP56_RS13165 ENOG4105MMD transcriptional regulator GOP56_RS13170 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) GOP56_RS13175 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) GOP56_RS13185 ENOG4107VRP DNA repair exonuclease GOP56_RS13195 ENOG4105FAA peptidase M23 GOP56_RS13200 ENOG4105D7N magnesium and cobalt transport protein CorA GOP56_RS13210 ENOG41082J7 Rhodanese domain protein GOP56_RS13215 ENOG4105CPI Metal Dependent Phosphohydrolase GOP56_RS13220 ENOG4105KZD Domain of unknown function (DUF1805) GOP56_RS13230 ENOG4105I3N Conserved Protein GOP56_RS13240 ENOG4105DIH basic membrane GOP56_RS13245 ENOG4105DIH basic membrane GOP56_RS13255 ENOG410681U heavy metal transport detoxification protein GOP56_RS13260 ENOG4105DZ6 Band 7 protein GOP56_RS13325 ENOG4105DIW FeS assembly protein SUFB GOP56_RS13330 ENOG4108UNV SUF system FeS assembly protein, NifU family GOP56_RS13335 ENOG4105C9B Cysteine desulfurase GOP56_RS13340 ENOG4105JRK feS assembly protein SufD GOP56_RS13345 ENOG4105C3K feS assembly ATPase SufC GOP56_RS13355 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase GOP56_RS13375 ENOG4105BZU Histidine kinase GOP56_RS13380 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GOP56_RS13390 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GOP56_RS13395 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GOP56_RS13400 ENOG4105D3R alkyl hydroperoxide reductase GOP56_RS13405 ENOG41080E8 Transcriptional regulator, Spx MgsR family GOP56_RS13440 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GOP56_RS13460 ENOG4108ISG Major Facilitator GOP56_RS13465 ENOG4105BZ1 (ABC) transporter GOP56_RS13475 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) GOP56_RS13485 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate GOP56_RS13490 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) GOP56_RS13495 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) GOP56_RS13500 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) GOP56_RS13515 ENOG4105CI1 PTS System GOP56_RS13525 ENOG4105FKQ transcriptional regulator GOP56_RS13530 ENOG4105C1G acyl-Coa dehydrogenase GOP56_RS13535 ENOG4105CHU acetyl-coa acetyltransferase GOP56_RS13555 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GOP56_RS13560 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) GOP56_RS13595 ENOG41082JN Transcriptional regulator GOP56_RS13605 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GOP56_RS13610 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GOP56_RS13615 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) GOP56_RS13620 ENOG4105DCF alanine dehydrogenase GOP56_RS13625 ENOG4108K8K Transcriptional regulator GOP56_RS13640 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E GOP56_RS13655 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GOP56_RS13665 ENOG4105J7I hydrolase GOP56_RS13670 ENOG4105D6N CoA-transferase, subunit a GOP56_RS13675 ENOG4108IIH CoA-transferase subunit B GOP56_RS13685 ENOG4105CIY formyltetrahydrofolate deformylase GOP56_RS13700 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation GOP56_RS13705 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination GOP56_RS13710 ENOG4105EYH Exonuclease GOP56_RS13725 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) GOP56_RS13730 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GOP56_RS13735 ENOG4107TSN permease GOP56_RS13770 ENOG4105C0A alcohol dehydrogenase GOP56_RS13780 ENOG4105DTD Dehydrogenase GOP56_RS13785 ENOG4105CY2 Citrate transporter GOP56_RS13790 ENOG4108JUB Transcriptional regulator GOP56_RS13795 ENOG4105K4I Scp-like extracellular GOP56_RS13810 ENOG4105EVU fructokinase GOP56_RS13815 ENOG410814C multidrug resistance protein GOP56_RS13830 ENOG4108R9S DSBA oxidoreductase GOP56_RS13840 ENOG4105NQC Flavodoxin GOP56_RS13850 ENOG4105C0R drug resistance transporter emrb qaca subfamily GOP56_RS13855 ENOG4105CW7 secretion protein, HlyD family GOP56_RS13890 ENOG4105EHG Permease protein GOP56_RS13895 ENOG4105DQ5 transport system permease protein GOP56_RS13900 ENOG4105F3H Histidine kinase GOP56_RS13905 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GOP56_RS13910 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GOP56_RS13915 ENOG4105C5E polysaccharide biosynthesis protein GOP56_RS13925 ENOG4108JQ7 (ABC) transporter GOP56_RS13935 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GOP56_RS13955 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GOP56_RS13985 ENOG4107TIF Phenazine biosynthesis protein, PhzF family GOP56_RS13995 ENOG4105X5K response regulator receiver protein GOP56_RS14040 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) GOP56_RS14045 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GOP56_RS14050 ENOG4105XZU Preprotein translocase, subunit SecG GOP56_RS14060 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GOP56_RS14070 ENOG4105CP7 Triose-phosphate isomerase GOP56_RS14075 ENOG4105BZA Phosphoglycerate kinase GOP56_RS14080 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GOP56_RS14095 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GOP56_RS14120 ENOG4105DU6 RNA polymerase GOP56_RS14135 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GOP56_RS14145 ENOG4105KRI phosphocarrier protein (HPr GOP56_RS14150 ENOG4105CIE May be required for sporulation (By similarity) GOP56_RS14155 ENOG4105CHW UPF0052 protein GOP56_RS14160 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GOP56_RS14165 ENOG4105C3M thioredoxin reductase GOP56_RS14215 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GOP56_RS14220 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GOP56_RS14225 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GOP56_RS14230 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GOP56_RS14235 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GOP56_RS14240 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GOP56_RS14245 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) GOP56_RS14250 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) GOP56_RS14255 ENOG4108S4C acetyltransferase GOP56_RS14260 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) GOP56_RS14265 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GOP56_RS14270 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GOP56_RS14275 ENOG410822I Flagellar hook capping protein GOP56_RS14285 ENOG4105CN1 protease GOP56_RS14290 ENOG4105DR5 peptidase GOP56_RS14295 ENOG4105CRP Part of the ABC transporter FtsEX involved in GOP56_RS14300 ENOG4105CAK Cell division ATP-binding protein ftsE GOP56_RS14305 ENOG4105CH7 arginosuccinase GOP56_RS14310 ENOG4105CDH Citrulline--aspartate ligase GOP56_RS14315 ENOG4105DBV ornithine carbamoyltransferase GOP56_RS14320 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GOP56_RS14325 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GOP56_RS14330 ENOG4105C8Y Acetylornithine aminotransferase GOP56_RS14335 ENOG4105CAS nag kinase GOP56_RS14340 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GOP56_RS14375 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GOP56_RS14380 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GOP56_RS14385 ENOG4105MS2 ribosomal subunit Interface protein GOP56_RS14390 ENOG4105VEQ Cold shock protein GOP56_RS14395 ENOG4106VK6 Flagellar motor protein GOP56_RS14400 ENOG4107R0U MotA TolQ exbB proton channel GOP56_RS14420 ENOG4105MQ3 flagellar protein FliS GOP56_RS14425 ENOG4107RT6 flagellar hook-associated GOP56_RS14430 ENOG41083S7 flagellar protein FlaG GOP56_RS14445 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) GOP56_RS14450 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) GOP56_RS14460 ENOG4105DTJ flagellar hook-associated protein GOP56_RS14465 ENOG4105E1Q flagellar hook-associated protein GOP56_RS14480 ENOG4105RU3 GOP56_RS14485 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GOP56_RS14515 ENOG4107BJW polysaccharide deacetylase GOP56_RS14520 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GOP56_RS14550 ENOG4107XI7 Tetr family transcriptional regulator GOP56_RS14555 ENOG4107QMU Mate efflux family protein GOP56_RS14565 ENOG4105T09 s-layer domain-containing protein GOP56_RS14575 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GOP56_RS14580 ENOG4105ESV Glycosyl transferase, family 4 GOP56_RS14595 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase GOP56_RS14605 ENOG4105CGA flagellar basal-body rod protein FlgG GOP56_RS14620 ENOG4105MT0 Sporulation transcriptional regulator spoiiid GOP56_RS14625 ENOG4105FRN stage II sporulation protein GOP56_RS14635 ENOG4105CHM Aminotransferase GOP56_RS14640 ENOG4108ZB6 transcriptional regulator AsnC family GOP56_RS14645 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GOP56_RS14655 ENOG4106778 Protein of unknown function (DUF1146) GOP56_RS14660 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GOP56_RS14665 ENOG4105C8S subunit m GOP56_RS14670 ENOG4105D65 subunit l GOP56_RS14675 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GOP56_RS14685 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GOP56_RS14690 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) GOP56_RS14695 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GOP56_RS14700 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GOP56_RS14705 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GOP56_RS14715 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin GOP56_RS14725 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GOP56_RS14730 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GOP56_RS14735 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GOP56_RS14740 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GOP56_RS14745 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GOP56_RS14760 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) GOP56_RS14775 ENOG4105CHU acetyl-coa acetyltransferase GOP56_RS14785 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GOP56_RS14790 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GOP56_RS14800 ENOG4108UIC UPF0340 protein GOP56_RS14805 ENOG4108YZG isomerase GOP56_RS14815 ENOG410815N Probably functions as a manganese efflux pump (By similarity) GOP56_RS14820 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GOP56_RS14825 ENOG4108ZXQ stage ii sporulation protein r GOP56_RS14830 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GOP56_RS14835 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GOP56_RS14850 ENOG41082DI 50s ribosomal protein l31 GOP56_RS14860 ENOG41069ER domain protein GOP56_RS14865 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) GOP56_RS14870 ENOG4105CBT Fructose-1,6-bisphosphatase GOP56_RS14875 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GOP56_RS14880 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GOP56_RS14885 ENOG4105D2N Aldolase GOP56_RS14890 ENOG410812K response regulator receiver protein GOP56_RS14895 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GOP56_RS14900 ENOG4108Z1Y Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity) GOP56_RS14905 ENOG4105D5P Methylmalonyl-coA mutase GOP56_RS14920 ENOG4105C1G acyl-Coa dehydrogenase GOP56_RS14925 ENOG4105C1G acyl-Coa dehydrogenase GOP56_RS14930 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GOP56_RS14940 ENOG4105DF6 Fe-S oxidoreductase GOP56_RS14945 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein GOP56_RS14950 ENOG4108JUB Transcriptional regulator GOP56_RS14965 ENOG4105CYW agmatinase GOP56_RS14970 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GOP56_RS14975 ENOG4105BZ4 penicillin-binding protein GOP56_RS14985 ENOG4108XFG YwhD family GOP56_RS14995 ENOG4105DCI Phosphohydrolase GOP56_RS15000 ENOG4108YBP pseudouridine synthase GOP56_RS15005 ENOG4105C88 aminopeptidase GOP56_RS15010 ENOG4108606 TspO/MBR family GOP56_RS15020 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) GOP56_RS15025 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GOP56_RS15030 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GOP56_RS15035 ENOG4108MES Periplasmic binding protein GOP56_RS15040 ENOG4105DQ5 transport system permease protein GOP56_RS15045 ENOG4108IHU transport system permease protein GOP56_RS15050 ENOG4105E0A ABC, transporter GOP56_RS15065 ENOG4105D38 putrescine abc transporter GOP56_RS15070 ENOG4107RUE extracellular solute-binding protein family 1 GOP56_RS15085 ENOG4105CFH Aspartokinase GOP56_RS15090 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GOP56_RS15100 ENOG4105CH6 catalase GOP56_RS15115 ENOG4105BZ1 (ABC) transporter GOP56_RS15120 ENOG4105BZ1 (ABC) transporter GOP56_RS15125 ENOG4105C26 Dehydrogenase GOP56_RS15135 ENOG4105EPD Oligopeptide transporter, Opt family GOP56_RS15140 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GOP56_RS15145 ENOG4105CVM Molybdenum cofactor synthesis domain protein GOP56_RS15150 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GOP56_RS15160 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GOP56_RS15185 ENOG4105CJ1 ABC, transporter GOP56_RS15200 ENOG4108RE7 deoxyribonuclease GOP56_RS15220 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase GOP56_RS15235 ENOG4105E5D amino acid GOP56_RS15240 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GOP56_RS15245 ENOG4108IJG ABC transporter substrate-binding protein GOP56_RS15250 ENOG4105DRS transport system, permease GOP56_RS15260 ENOG4108IJ9 (ABC) transporter GOP56_RS15275 ENOG4105C8Q Methyl-accepting chemotaxis GOP56_RS15310 ENOG4105C5H ABC transporter GOP56_RS15315 ENOG4105DNP FAD linked oxidase domain protein GOP56_RS15320 ENOG4105JVQ RNA Polymerase GOP56_RS15335 ENOG4105CGH 5'-nucleotidase GOP56_RS15340 ENOG4105C9U ATP-dependent DNA helicase RecQ GOP56_RS15345 ENOG4108MJI response regulator GOP56_RS15355 ENOG4105BZU Histidine kinase GOP56_RS15360 ENOG4105BZU Histidine kinase GOP56_RS15365 ENOG4107TVC Glycosyl transferase, family 2 GOP56_RS15370 ENOG4105FE9 pseudouridine synthase GOP56_RS15375 ENOG4107TS3 membrane protein, TerC GOP56_RS15380 ENOG4105C2C drug resistance transporter, Bcr CflA GOP56_RS15385 ENOG4105C1J atp-dependent rna helicase GOP56_RS15430 ENOG41060D1 Quinol oxidase GOP56_RS15435 ENOG4105DG6 mannose-6-phosphate isomerase GOP56_RS15440 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GOP56_RS15455 ENOG4105CY5 solute-binding protein GOP56_RS15460 ENOG4105CXY transporter GOP56_RS15475 ENOG4105DRP amino acid AbC transporter GOP56_RS15480 ENOG4105EAD ABC transporter GOP56_RS15495 ENOG4105F32 YngK protein GOP56_RS15505 ENOG4105C8Q Methyl-accepting chemotaxis GOP56_RS15510 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) GOP56_RS15515 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GOP56_RS15520 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GOP56_RS15525 ENOG4105ECK Fatty Acid Desaturase GOP56_RS15530 ENOG4108SA1 esterase GOP56_RS15580 ENOG4105C8Q Methyl-accepting chemotaxis GOP56_RS15595 ENOG4105JVQ RNA Polymerase GOP56_RS15600 ENOG410667J hydrolase GOP56_RS15610 ENOG4105IJJ transcriptional regulator, crp fnr family GOP56_RS15635 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GOP56_RS15645 ENOG4105KVH Transcriptional regulator GOP56_RS15650 ENOG4105F27 Major Facilitator GOP56_RS15655 ENOG4105CV8 reductase GOP56_RS15680 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) GOP56_RS15685 ENOG4105DWT malate dehydrogenase (quinone) GOP56_RS15705 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) GOP56_RS15725 ENOG4105C0H protease GOP56_RS15735 ENOG4105Q2H domain protein GOP56_RS15750 ENOG4105BZU Histidine kinase GOP56_RS15760 ENOG4105DR5 peptidase GOP56_RS15775 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GOP56_RS15780 ENOG4105CDU Replicative dna helicase GOP56_RS15785 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GOP56_RS15790 ENOG4105BZR domain protein GOP56_RS15800 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GOP56_RS15805 ENOG4108UUM single-stranded DNA-binding protein GOP56_RS15810 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) GOP56_RS15815 ENOG4105C3G gtp-binding protein GOP56_RS15830 ENOG4105DPN Oligoendopeptidase f GOP56_RS15835 ENOG4105VDK protein, conserved in bacteria GOP56_RS15840 ENOG4105D8X mechanosensitive ion channel GOP56_RS15850 ENOG4108ZDA Sporulation protein YyaC GOP56_RS15855 ENOG4105C9B Cysteine desulfurase GOP56_RS15860 ENOG4105FA0 parb-like partition protein GOP56_RS15865 ENOG4107QJE Chromosome Partitioning Protein GOP56_RS15875 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GOP56_RS15880 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GOP56_RS15885 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) GOP56_RS15890 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein GOP56_RS15895 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GOP56_RS15900 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GOP56_RS15905 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) GOP56_RS15910 ENOG4105VG0 50S ribosomal protein l34 GOP56_RS15915 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GOP56_RS15920 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GOP56_RS15925 ENOG410848D S4 domain protein YaaA GOP56_RS15930 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GOP56_RS15940 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GOP56_RS15955 ENOG4105C31 Tryptophanyl-tRNA synthetase GOP56_RS15965 ENOG4105C19 ABC transporter GOP56_RS15975 ENOG41082K6 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GOP56_RS15980 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GOP56_RS15985 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GOP56_RS15990 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) GOP56_RS15995 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GOP56_RS16000 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GOP56_RS16010 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GOP56_RS16015 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GOP56_RS16020 ENOG4105CPI Metal Dependent Phosphohydrolase GOP56_RS16045 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GOP56_RS16055 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) GOP56_RS16060 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) GOP56_RS16065 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GOP56_RS16070 ENOG4107QP3 malate synthase g GOP56_RS16080 ENOG41082AN stage II sporulation protein GOP56_RS16085 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) GOP56_RS16100 ENOG4108Z6B deaminase GOP56_RS16115 ENOG4105BZU Histidine kinase GOP56_RS16120 ENOG4105C6E dna polymerase iii GOP56_RS16125 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) GOP56_RS16130 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GOP56_RS16145 ENOG41067KS pro-sigma K processing GOP56_RS16170 ENOG4105CXN decarboxylase GOP56_RS16175 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GOP56_RS16180 ENOG4105X0R protein from nitrogen regulatory protein P-II GOP56_RS16185 ENOG4105XVJ Protein of unknown function (DUF327) GOP56_RS16190 ENOG4105FA2 dna polymerase iii GOP56_RS16195 ENOG4105MA4 psp1 domain protein GOP56_RS16200 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) GOP56_RS16205 ENOG41060K3 Methyltransferase GOP56_RS16210 ENOG4105VC4 domain protein GOP56_RS16215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GOP56_RS16220 ENOG4105KRN Transcriptional regulator, abrb family GOP56_RS16225 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GOP56_RS16230 ENOG4105F8V Hydrolase, tatD family GOP56_RS16235 ENOG41069ER domain protein GOP56_RS16240 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) GOP56_RS16245 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GOP56_RS16250 ENOG4105W42 Veg protein GOP56_RS16255 ENOG4105XEW small acid-soluble spore protein GOP56_RS16260 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GOP56_RS16265 ENOG4105DFT pur operon repressor GOP56_RS16270 ENOG4105K4W Could be involved in septation (By similarity) GOP56_RS16280 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GOP56_RS16285 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GOP56_RS16290 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GOP56_RS16295 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GOP56_RS16305 ENOG4108JA2 transcriptioN-repair coupling factor GOP56_RS16310 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GOP56_RS16315 ENOG4108M14 stage v sporulation protein t GOP56_RS16325 ENOG4108IY2 MazG family GOP56_RS16330 ENOG41082I2 s4 domain protein GOP56_RS16335 ENOG4105VYY sporulation protein yabp GOP56_RS16380 ENOG4108UGV hypoxanthine phosphoribosyltransferase GOP56_RS16385 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GOP56_RS16390 ENOG410667J hydrolase GOP56_RS16395 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GOP56_RS16405 ENOG4105DSE periplasmic solute binding protein GOP56_RS16415 ENOG4105FDK ABC transporter GOP56_RS16420 ENOG4105FAV ABC, transporter GOP56_RS16425 ENOG4105N80 Ferric uptake regulator, Fur family GOP56_RS16435 ENOG4108IYU L-aspartate oxidase GOP56_RS16440 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GOP56_RS16445 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) GOP56_RS16465 ENOG4107U53 septum site-determining protein minD GOP56_RS16530 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GOP56_RS16540 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) GOP56_RS16545 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase GOP56_RS16550 ENOG4105C6T cysteine synthase GOP56_RS16555 ENOG4105DDQ anthranilate synthase GOP56_RS16560 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 GOP56_RS16565 ENOG4105EEI dihydropteroate synthase GOP56_RS16570 ENOG4105KRF dihydroneopterin aldolase GOP56_RS16575 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GOP56_RS16585 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GOP56_RS16630 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 GOP56_RS16640 ENOG4108Z0C Uvrb UvrC protein GOP56_RS16645 ENOG41066A3 ATP guanido phosphotransferase GOP56_RS16655 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GOP56_RS16660 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) GOP56_RS16665 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase GOP56_RS16675 ENOG4105CTP PilT protein domain protein GOP56_RS16680 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GOP56_RS16685 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GOP56_RS16690 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GOP56_RS16695 ENOG4105D7W serine acetyltransferase GOP56_RS16700 ENOG4105C8N cysteinyl-tRNA synthetase GOP56_RS16705 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) GOP56_RS16710 ENOG4105C2N RNA methyltransferase TrmH family group 3 GOP56_RS16715 ENOG4105M0M Tetracycline resistance protein GOP56_RS16720 ENOG4105QIV RNA polymerase GOP56_RS16725 ENOG4105WDJ 50S ribosomal protein L33 GOP56_RS16735 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GOP56_RS16740 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GOP56_RS16745 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) GOP56_RS16750 ENOG4108VZM 50s ribosomal protein L10 GOP56_RS16755 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GOP56_RS16760 ENOG4107Y49 methyltransferase GOP56_RS16765 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GOP56_RS16770 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GOP56_RS16775 ENOG4105XPM ribosomal protein GOP56_RS16780 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GOP56_RS16785 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GOP56_RS16790 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GOP56_RS16795 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GOP56_RS16805 ENOG4108Z18 K06886 hemoglobin GOP56_RS16810 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) GOP56_RS16815 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GOP56_RS16820 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GOP56_RS16825 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) GOP56_RS16830 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity GOP56_RS16835 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GOP56_RS16840 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GOP56_RS16845 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GOP56_RS16850 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GOP56_RS16855 ENOG41082SA 50s ribosomal protein l29 GOP56_RS16860 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GOP56_RS16865 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GOP56_RS16870 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) GOP56_RS16875 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GOP56_RS16880 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GOP56_RS16885 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GOP56_RS16890 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GOP56_RS16895 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) GOP56_RS16900 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GOP56_RS16905 ENOG4105VPB 50S ribosomal protein L30 GOP56_RS16910 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GOP56_RS16915 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GOP56_RS16920 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GOP56_RS16925 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GOP56_RS16930 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GOP56_RS16935 ENOG41067V7 50S ribosomal protein L36 GOP56_RS16940 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GOP56_RS16945 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GOP56_RS16950 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GOP56_RS16955 ENOG4108ZT0 50S ribosomal protein l17 GOP56_RS16960 ENOG4108JJB ABC transporter GOP56_RS16965 ENOG4105BZ1 (ABC) transporter GOP56_RS16970 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) GOP56_RS16975 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GOP56_RS16980 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GOP56_RS16985 ENOG4108UJD 30S ribosomal protein S9 GOP56_RS17000 ENOG4105D1F ATP-binding protein GOP56_RS17015 ENOG4108NMV polysaccharide deacetylase GOP56_RS17105 ENOG4105CYW agmatinase GOP56_RS17110 ENOG4105EMN RNA polymerase sigma factor GOP56_RS17120 ENOG4105C8B TIGR00159 family GOP56_RS17125 ENOG4107U5W ybbr family GOP56_RS17130 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GOP56_RS17135 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GOP56_RS17175 ENOG4105C4R Atp-dependent dna helicase GOP56_RS17245 ENOG4105DZR Type I site-specific deoxyribonuclease GOP56_RS17290 ENOG4105HIR S-layer domain protein GOP56_RS17295 ENOG41080UQ Transcriptional regulator GOP56_RS17305 ENOG4108Z66 YbaK ebsC protein GOP56_RS17310 ENOG4105CKI cobalamin synthesis protein GOP56_RS17315 ENOG410861F 50S ribosomal protein L33 GOP56_RS17335 ENOG4105DXD 2-methylcitrate dehydratase GOP56_RS17340 ENOG4105CR4 methylisocitrate lyase GOP56_RS17350 ENOG4105C1G acyl-Coa dehydrogenase GOP56_RS17360 ENOG4105C26 Dehydrogenase GOP56_RS17385 ENOG41067SE Tetr family transcriptional regulator GOP56_RS17410 ENOG4107RWR Sodium hydrogen exchanger GOP56_RS17420 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) GOP56_RS17425 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase GOP56_RS17435 ENOG4108J2R molybdopterin oxidoreductase GOP56_RS17445 ENOG410874W AraC family transcriptional regulator GOP56_RS17475 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GOP56_RS17480 ENOG4105BZU Histidine kinase GOP56_RS17500 ENOG4105FAW cDP-glucose 4,6-dehydratase GOP56_RS17505 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase GOP56_RS17515 ENOG4107ZTW SNARE associated Golgi GOP56_RS17525 ENOG4105BZ1 (ABC) transporter GOP56_RS17530 ENOG4105BZ1 (ABC) transporter GOP56_RS17535 ENOG4105DHF Membrane GOP56_RS17550 ENOG4108HWY Beta-lactamase GOP56_RS17560 ENOG4107RVG penicillin-binding protein GOP56_RS17570 ENOG4107258 Transcriptional regulator GOP56_RS17575 ENOG4105E7W lamb ycsf family protein GOP56_RS17595 ENOG4105P4J Allophanate hydrolase, subunit 1 GOP56_RS17610 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein GOP56_RS17615 ENOG4108I5D sulfate abc transporter GOP56_RS17620 ENOG4105ECW sulfate abc transporter GOP56_RS17625 ENOG4108IJ6 ABC transporter GOP56_RS17630 ENOG4108XBJ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) GOP56_RS17635 ENOG4105D9R oxidoreductase GOP56_RS17640 ENOG4107YZX Universal stress protein GOP56_RS17645 ENOG4105DHI Methyltransferase GOP56_RS17650 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase GOP56_RS17655 ENOG4105XTG Pfam:DUF156 GOP56_RS17660 ENOG4105C8J )-transporter GOP56_RS17665 ENOG4108RMU ferritin dps family protein GOP56_RS17695 ENOG4108RPX mosc domain containing protein GOP56_RS17710 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) GOP56_RS17715 ENOG4108V2W Carbonate dehydratase GOP56_RS17720 ENOG4108J59 Extracellular solute-binding protein, family 5 GOP56_RS17725 ENOG4107V6Q Cyclic nucleotide-binding domain GOP56_RS17730 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GOP56_RS17735 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b GOP56_RS17745 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GOP56_RS17750 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GOP56_RS17770 ENOG4105GPN Uncharacterized conserved protein (DUF2294) GOP56_RS17860 ENOG4105ENE Histidine kinase GOP56_RS17865 ENOG4105WH1 Two component transcriptional regulator luxr family GOP56_RS17885 ENOG4105EA8 2-Nitropropane dioxygenase GOP56_RS17895 ENOG4105BZN citrate synthase GOP56_RS17900 ENOG4105ENE Histidine kinase GOP56_RS17905 ENOG4105WH1 Two component transcriptional regulator luxr family GOP56_RS17910 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GOP56_RS17945 ENOG41082J7 Rhodanese domain protein GOP56_RS17960 ENOG4105CVA phosphate GOP56_RS17965 ENOG4105C8U phosphate abc transporter GOP56_RS17970 ENOG4105E2Z phosphate ABC transporter (Permease GOP56_RS17980 ENOG4105CN5 Metallo-Beta-Lactamase GOP56_RS17985 ENOG4108Y6J UPF0403 protein GOP56_RS18005 ENOG4108KGH TRANSCRIPTIONal GOP56_RS18010 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GOP56_RS18015 ENOG4108UMI ABC transporter, permease GOP56_RS18020 ENOG4105D01 (LipO)protein GOP56_RS18030 ENOG4105D06 uba thif-type nad fad binding protein GOP56_RS18035 ENOG4108J59 Extracellular solute-binding protein, family 5 GOP56_RS18040 ENOG4108J59 Extracellular solute-binding protein, family 5 GOP56_RS18065 ENOG4105WG9 Conserved Protein GOP56_RS18070 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GOP56_RS18075 ENOG41080HT Transcriptional regulator, arsr family GOP56_RS18085 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein GOP56_RS18095 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GOP56_RS18105 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) GOP56_RS18125 ENOG410906U SprT-like GOP56_RS18130 ENOG4105K8N protein family UPF0079, ATPase GOP56_RS18135 ENOG41072GX Peptidase M22 Glycoprotease GOP56_RS18140 ENOG410801F ribosomal-protein-alanine acetyltransferase GOP56_RS18145 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GOP56_RS18155 ENOG4105C5H ABC transporter GOP56_RS18160 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GOP56_RS18165 ENOG4108RIR Molybdenum cofactor biosynthesis protein GOP56_RS18175 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GOP56_RS18180 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GOP56_RS18185 ENOG4106I4J membrane GOP56_RS18195 ENOG4106UY4 Inherit from COG: Scp-like extracellular GOP56_RS18200 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GOP56_RS18325 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GOP56_RS18345 ENOG4105C7N Xanthine uracil vitamin C permease GOP56_RS18350 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GOP56_RS18355 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit GOP56_RS18360 ENOG4105C83 adenylosuccinate lyase GOP56_RS18365 ENOG4105C88 aminopeptidase GOP56_RS18370 ENOG4107QW4 alcohol dehydrogenase GOP56_RS18375 ENOG4105C8V SAICAR synthetase GOP56_RS18380 ENOG4105VR9 phosphoribosylformylglycinamidine synthase GOP56_RS18385 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I GOP56_RS18400 ENOG4105CXB phosphoribosylaminoimidazole synthetase GOP56_RS18405 ENOG4108V3E phosphoribosylglycinamide formyltransferase GOP56_RS18415 ENOG4106YBV Methyl-accepting chemotaxis GOP56_RS18425 ENOG4105K4T epimerase GOP56_RS18435 ENOG4105C12 Phosphoribosylglycinamide synthetase GOP56_RS18455 ENOG4105C32 Amino acid ABC transporter (Permease) GOP56_RS18460 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GOP56_RS18465 ENOG4105C0Z ABC transporter GOP56_RS18470 ENOG4108IV0 ABC, transporter GOP56_RS18475 ENOG4105VRS hydrolase family 18 GOP56_RS18480 ENOG4105F3H Histidine kinase GOP56_RS18490 ENOG4108R5T secreted protein GOP56_RS18495 ENOG4105KGF protein, YerC YecD GOP56_RS18500 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) GOP56_RS18505 ENOG4105C4R Atp-dependent dna helicase GOP56_RS18510 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GOP56_RS18525 ENOG4105C26 Dehydrogenase GOP56_RS18535 ENOG4107SDU Methyl-accepting chemotaxis GOP56_RS18540 ENOG4105DJ4 phosphatidylserine decarboxylase GOP56_RS18565 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GOP56_RS18570 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GOP56_RS18580 ENOG4105C19 ABC transporter GOP56_RS18585 ENOG4107RBB ABC transporter, permease GOP56_RS18590 ENOG4105C42 Type I secretion membrane fusion protein (HlyD GOP56_RS18610 ENOG4108IUW ABC transporter GOP56_RS18625 ENOG4108IUW ABC transporter GOP56_RS18630 ENOG4108SDH ABC, transporter GOP56_RS18635 ENOG4105DKQ ROK family GOP56_RS18640 ENOG4105CBD Diacylglycerol kinase GOP56_RS18645 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GOP56_RS18680 ENOG41087PP glycosyltransferase MGT family GOP56_RS18705 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein GOP56_RS18715 ENOG4105CHR reductase GOP56_RS18735 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GOP56_RS18785 ENOG4105D9U N-acetyltransferase GOP56_RS18795 ENOG4105C8Q Methyl-accepting chemotaxis GOP56_RS18810 ENOG4108V5C ABC transporter GOP56_RS18815 ENOG4105UA4 acetyltransferase GOP56_RS18820 ENOG4105C8J )-transporter GOP56_RS18825 ENOG4107U9B transcriptional regulator GOP56_RS18845 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GOP56_RS18855 ENOG4105BZ1 (ABC) transporter GOP56_RS18875 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GOP56_RS18880 ENOG4105CJ1 ABC, transporter GOP56_RS18935 ENOG4105CEY Amp-dependent synthetase and ligase GOP56_RS18940 ENOG4108HYG acetyltransferase GOP56_RS18955 ENOG4107K5X Membrane-bound metal-dependent hydrolase GOP56_RS18960 ENOG4105E63 Pfam:DUF178 GOP56_RS18965 ENOG4108UIH futalosine nucleosidase GOP56_RS18970 ENOG4105CSV Glutaminase GOP56_RS18990 ENOG4108428 Inherit from COG: -acetyltransferase GOP56_RS18995 ENOG4105KK4 UPF0060 membrane protein GOP56_RS19005 ENOG4105C7B Threonine dehydratase GOP56_RS19010 ENOG4108IQI permease GOP56_RS19015 ENOG4108JUB Transcriptional regulator GOP56_RS19020 ENOG4105C8Y Acetylornithine aminotransferase GOP56_RS19025 ENOG4105CV8 reductase GOP56_RS19035 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) GOP56_RS19045 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase GOP56_RS19050 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GOP56_RS19055 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) GOP56_RS19060 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GOP56_RS19065 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GOP56_RS19080 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GOP56_RS19090 ENOG4105DWF phosphomethylpyrimidine kinase GOP56_RS19110 ENOG4105CIG ABC transporter GOP56_RS19120 ENOG4108URH decarboxylase GOP56_RS19125 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain GOP56_RS19145 ENOG4105CPI Metal Dependent Phosphohydrolase GOP56_RS19150 ENOG4105EHZ conserved protein UCP016719 GOP56_RS19155 ENOG4105E14 MotA TolQ exbB proton channel GOP56_RS19160 ENOG4105ER2 Ompa motb domain protein GOP56_RS19170 ENOG4108ZUB Lysine exporter protein (Lyse ygga) GOP56_RS19175 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GOP56_RS19215 ENOG4107RBB ABC transporter, permease GOP56_RS19220 ENOG4105C19 ABC transporter GOP56_RS19225 ENOG4105CW7 secretion protein, HlyD family GOP56_RS19240 ENOG4105MWK D-amino acid dehydrogenase, small subunit GOP56_RS19250 ENOG4105VRS hydrolase family 18 GOP56_RS19260 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GOP56_RS19290 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GOP56_RS19295 ENOG4105QNR S1 RNA binding domain protein GOP56_RS19300 ENOG4106A3M Cytochrome p-450 GOP56_RS19320 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GOP56_RS19325 ENOG4105DVE abc transporter atp-binding protein GOP56_RS19335 ENOG4108JUB Transcriptional regulator GOP56_RS19360 ENOG4108TGP Thioesterase superfamily protein GOP56_RS19375 ENOG4108PCN EamA-like transporter family GOP56_RS19405 ENOG4105C5H ABC transporter GOP56_RS19410 ENOG4108YBP pseudouridine synthase GOP56_RS19420 ENOG4105BZ4 penicillin-binding protein GOP56_RS19425 ENOG4105KPY Small multidrug resistance protein GOP56_RS19450 ENOG4105BZU Histidine kinase GOP56_RS19455 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GOP56_RS19460 ENOG4108QBX (LipO)protein GOP56_RS19470 ENOG41087YS Phage shock protein A GOP56_RS19485 ENOG4105ENE Histidine kinase GOP56_RS19490 ENOG4105WH1 Two component transcriptional regulator luxr family GOP56_RS19495 ENOG4107S1Q Phosphatase GOP56_RS19505 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GOP56_RS19515 ENOG4105EJ9 Membrane GOP56_RS19530 ENOG41067AE Membrane-bound metal-dependent hydrolase GOP56_RS19540 ENOG4105CAN Short-chain dehydrogenase reductase Sdr GOP56_RS19560 ENOG4105BZ1 (ABC) transporter GOP56_RS19565 ENOG4105C6X Major Facilitator GOP56_RS19590 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GOP56_RS19595 ENOG4108IUW ABC transporter GOP56_RS19615 ENOG4107XGZ Hydrolase GOP56_RS19625 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GOP56_RS19630 ENOG4105DER m42 family GOP56_RS19635 ENOG4108D32 Methyltransferase GOP56_RS19640 ENOG4108WBT adenosyltransferase GOP56_RS19645 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase GOP56_RS19650 ENOG4105CSM endonuclease III GOP56_RS19655 ENOG4105G5W regulator Fur family GOP56_RS19665 ENOG4105TUA UPF0295 protein GOP56_RS19760 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GOP56_RS19765 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GOP56_RS19770 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GOP56_RS19795 ENOG4105CYN Serine protein kinase GOP56_RS19835 ENOG4105BZU Histidine kinase GOP56_RS19845 ENOG4105BZU Histidine kinase GOP56_RS19860 ENOG4105CGH 5'-nucleotidase GOP56_RS19870 ENOG4107S9D Alpha beta hydrolase GOP56_RS19875 ENOG4105DWD nucleoside recognition domain protein GOP56_RS19885 ENOG4108Z0Z intracellular protease Pfpi family GOP56_RS19890 ENOG4108UZ3 Transporter GOP56_RS19910 ENOG4105CIF Ornithine Cyclodeaminase GOP56_RS19915 ENOG4105ED1 spovr family GOP56_RS19920 ENOG4107Y5K Resolvase GOP56_RS20035 ENOG4108PNI recT protein GOP56_RS20135 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GOP56_RS20150 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GOP56_RS20190 ENOG4108MRH transcriptional regulatory protein GOP56_RS20200 ENOG4105C5I Dehydrogenase GOP56_RS20215 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GOP56_RS20220 ENOG4105BZU Histidine kinase GOP56_RS20230 ENOG4105C19 ABC transporter GOP56_RS20235 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GOP56_RS20245 ENOG4105CPI Metal Dependent Phosphohydrolase GOP56_RS20250 ENOG4105CQB FAD linked oxidase domain protein GOP56_RS20270 ENOG4108MK9 spermidine N(1)-acetyltransferase GOP56_RS20275 ENOG41090KR LysR family transcriptional Regulator GOP56_RS20295 ENOG4106ETB IIa component GOP56_RS20310 ENOG4105E98 transcriptional regulator DeoR family GOP56_RS20315 ENOG4105DE4 1-phosphofructokinase GOP56_RS20320 ENOG4105DM4 PTS System GOP56_RS20325 ENOG4105KRI phosphocarrier protein (HPr GOP56_RS20330 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GOP56_RS20340 ENOG4105DUU IucA IucC family protein GOP56_RS20360 ENOG4108WBH protein TIM barrel GOP56_RS20365 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) GOP56_RS20370 ENOG4108A65 Transcriptional regulator GOP56_RS20380 ENOG4108UT2 hemolysin iii GOP56_RS20385 ENOG4105C1J atp-dependent rna helicase GOP56_RS20405 ENOG4105BZU Histidine kinase GOP56_RS20410 ENOG4105HMI Membrane GOP56_RS20450 ENOG410839P GOP56_RS20470 ENOG4105DFD Na H antiporter GOP56_RS20480 ENOG4105WZB UPF0342 protein GOP56_RS20500 ENOG4105C0B DNA polymerase III (alpha subunit) GOP56_RS20505 ENOG4105C6K Malic enzyme GOP56_RS20510 ENOG4105JXH GntR family transcriptional regulator GOP56_RS20520 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) GOP56_RS20525 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) GOP56_RS20530 ENOG4105CTQ phosphohexokinase GOP56_RS20550 ENOG4108REF Sporulation integral membrane protein ytvi GOP56_RS20555 ENOG4105BZN citrate synthase GOP56_RS20560 ENOG4108HMX isocitrate dehydrogenase (NADP) GOP56_RS20565 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GOP56_RS20570 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GOP56_RS20575 ENOG4105BZU Histidine kinase GOP56_RS20580 ENOG41073R8 VanW family GOP56_RS20585 ENOG4108JYZ YitT family GOP56_RS20595 ENOG4105C2M dna polymerase I GOP56_RS20600 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GOP56_RS20610 ENOG4105E4C Lytic transglycosylase catalytic GOP56_RS20620 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GOP56_RS20625 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) GOP56_RS20630 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GOP56_RS20635 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) GOP56_RS20650 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GOP56_RS20655 ENOG4105EXW epimerase dehydratase GOP56_RS20665 ENOG4105CF7 AraC family transcriptional regulator GOP56_RS20670 ENOG4108M1A Chitin-binding protein GOP56_RS20675 ENOG4108M1A Chitin-binding protein GOP56_RS20680 ENOG4107414 GntR family transcriptional regulator GOP56_RS20690 ENOG4105C5Y PTS System GOP56_RS20695 ENOG4105CG3 alpha amylase, catalytic region GOP56_RS20735 ENOG4105CJ1 ABC, transporter GOP56_RS20745 ENOG4108FN7 Aldo keto reductase GOP56_RS20750 ENOG4105C0W non-ribosomal peptide synthetase GOP56_RS20765 ENOG4106JUT Streptomycin 3''-adenylyltransferase GOP56_RS20795 ENOG4105KNA -acetyltransferase GOP56_RS20820 ENOG4108NVR Methyl-accepting chemotaxis GOP56_RS20830 ENOG4105C8Q Methyl-accepting chemotaxis GOP56_RS20835 ENOG4105NCW Trka-c domain protein GOP56_RS20840 ENOG4107S91 Sodium hydrogen exchanger GOP56_RS20855 ENOG4105DU6 RNA polymerase GOP56_RS20870 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GOP56_RS20910 ENOG4105C26 Dehydrogenase GOP56_RS20915 ENOG4105K56 Transcriptional regulator GOP56_RS20950 ENOG4105E5G Alpha beta hydrolase fold GOP56_RS20965 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GOP56_RS20980 ENOG4105WGB oxidoreductase, delta subunit GOP56_RS20985 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) GOP56_RS20990 ENOG4105VKD bioY protein GOP56_RS21000 ENOG4105DU0 nucleoside hydrolase GOP56_RS21055 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase GOP56_RS21065 ENOG4105DQ6 Transposase GOP56_RS21070 ENOG4108NHD germination protein GOP56_RS21085 ENOG4108MES Periplasmic binding protein GOP56_RS21090 ENOG4108IHU transport system permease protein GOP56_RS21095 ENOG4105DQ5 transport system permease protein GOP56_RS21105 ENOG4107EFR Flavocytochrome c GOP56_RS21115 ENOG4108YTE sporulation protein YunB GOP56_RS21120 ENOG4108X4Q Hydrolase GOP56_RS21125 ENOG4108IFG nitrite reductase, (NAD(P)H) GOP56_RS21130 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit GOP56_RS21140 ENOG4105F1A Pyruvate formate-lyase GOP56_RS21150 ENOG4105ETD TRANSCRIPTIONal GOP56_RS21160 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase GOP56_RS21165 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein GOP56_RS21175 ENOG4107Y80 Major Facilitator superfamily GOP56_RS21180 ENOG4105DPN Oligoendopeptidase f GOP56_RS21185 ENOG4105CIN aminoacyl-histidine dipeptidase GOP56_RS21190 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GOP56_RS21195 ENOG4108JPW Aminotransferase GOP56_RS21220 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) GOP56_RS21225 ENOG4105BZ9 Cytochrome C oxidase, subunit I GOP56_RS21255 ENOG4108VKI Cell wall hydrolase GOP56_RS21260 ENOG4105CUB amino acid GOP56_RS21280 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) GOP56_RS21300 ENOG4105EAH synthase GOP56_RS21335 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GOP56_RS21340 ENOG4105C8Y Acetylornithine aminotransferase GOP56_RS21345 ENOG4105CFP Peptidase U32 GOP56_RS21350 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) GOP56_RS21355 ENOG4108JJB ABC transporter GOP56_RS21360 ENOG4108JJB ABC transporter GOP56_RS21385 ENOG4105C22 threonyL-tRNA synthetase GOP56_RS21390 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GOP56_RS21395 ENOG4105VJV 50s ribosomal protein L35 GOP56_RS21400 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GOP56_RS21405 ENOG4105C28 cystathionine GOP56_RS21410 ENOG4105C28 cystathionine GOP56_RS21420 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) GOP56_RS21425 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GOP56_RS21430 ENOG4107RIQ Sulfate adenylate transferase GOP56_RS21435 ENOG4105C7K acetolactate synthase GOP56_RS21440 ENOG4108ZP8 Acetolactate synthase small subunit GOP56_RS21445 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GOP56_RS21450 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GOP56_RS21455 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GOP56_RS21460 ENOG4105CZN Potassium uptake protein GOP56_RS21470 ENOG4105C2I pirin domain protein GOP56_RS21475 ENOG4105EPU Molybdenum cofactor synthesis domain protein GOP56_RS21485 ENOG4107ZTW SNARE associated Golgi GOP56_RS21495 ENOG4105CN9 Peptidase m42 family protein GOP56_RS21500 ENOG41067MF small acid-soluble spore protein GOP56_RS21505 ENOG4107ZYR domain protein GOP56_RS21510 ENOG4108RWN rrna methyltransferase GOP56_RS21525 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) GOP56_RS21535 ENOG4105C98 muts2 protein GOP56_RS21545 ENOG4108IJ1 Dehydrogenase GOP56_RS21550 ENOG4108ME1 Peptidase M55 D-aminopeptidase GOP56_RS21555 ENOG4107TAE Glycosyl transferase (Group 1 GOP56_RS21580 ENOG4105CJR Integral membrane protein (MviN GOP56_RS21620 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GOP56_RS21625 ENOG4105EHG Permease protein GOP56_RS21630 ENOG4105E0A ABC, transporter GOP56_RS21635 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GOP56_RS21645 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GOP56_RS21650 ENOG4105CHU acetyl-coa acetyltransferase GOP56_RS21655 ENOG4108KGH TRANSCRIPTIONal GOP56_RS21660 ENOG4105CEY Amp-dependent synthetase and ligase GOP56_RS21665 ENOG4107Z3H Transcriptional regulator, TetR family GOP56_RS21670 ENOG41060WC Enoyl-CoA hydratase GOP56_RS21675 ENOG4105BZJ Electron transfer flavoprotein GOP56_RS21680 ENOG4105C10 Electron transfer flavoprotein GOP56_RS21690 ENOG4105K63 Thioredoxin GOP56_RS21695 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GOP56_RS21700 ENOG4105E1F short-chain dehydrogenase reductase GOP56_RS21715 ENOG4105DWV Homoserine O-trans-acetylase GOP56_RS21730 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit GOP56_RS21740 ENOG4105E33 succinate dehydrogenase GOP56_RS21755 ENOG410650H (LipO)protein GOP56_RS21760 ENOG4105DBE peroxidase GOP56_RS21765 ENOG4107SJW iron permease, FTR1 GOP56_RS21770 ENOG4105CID antiterminator GOP56_RS21775 ENOG4105C5Y PTS System GOP56_RS21780 ENOG4105CS2 ec 3.2.1.21 GOP56_RS21785 ENOG4105PFC Transcriptional regulator GOP56_RS21790 ENOG4105N67 Proton-coupled thiamine transporter YuaJ GOP56_RS21805 ENOG4107Y03 Nitroreductase GOP56_RS21810 ENOG4105E4R Precorrin-3B C17-methyltransferase GOP56_RS21815 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein GOP56_RS21820 ENOG4108JTQ reductase GOP56_RS21825 ENOG41081F0 Precorrin-8x methylmutase GOP56_RS21830 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) GOP56_RS21835 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase GOP56_RS21840 ENOG4105DVK Precorrin-2 c20-methyltransferase GOP56_RS21845 ENOG4105CIA precorrin-4 C(11)-methyltransferase GOP56_RS21850 ENOG4108P62 biosynthesis protein (CbiG) GOP56_RS21855 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GOP56_RS21860 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase GOP56_RS21865 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GOP56_RS21870 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) GOP56_RS21875 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) GOP56_RS21885 ENOG4108JJB ABC transporter GOP56_RS21890 ENOG4105K70 DNA-binding protein GOP56_RS21895 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GOP56_RS21900 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GOP56_RS21905 ENOG4107SWG transcriptional regulator MERR family GOP56_RS21910 ENOG4105DXB Major Facilitator superfamily GOP56_RS21915 ENOG4108XJQ germination protein GOP56_RS21920 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GOP56_RS21925 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GOP56_RS21930 ENOG4105M59 Phosphodiesterase, mj0936 family GOP56_RS21935 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GOP56_RS21940 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GOP56_RS21945 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GOP56_RS21950 ENOG4108IUQ atp-dependent protease GOP56_RS21960 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) GOP56_RS21965 ENOG4105CPE K01197 hyaluronoglucosaminidase EC 3.2.1.35 GOP56_RS21975 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GOP56_RS21985 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GOP56_RS21990 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GOP56_RS21995 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GOP56_RS22000 ENOG4105D52 delta-aminolevulinic acid dehydratase GOP56_RS22010 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GOP56_RS22025 ENOG41068KH stage VI sporulation protein D GOP56_RS22045 ENOG4108JYZ YitT family GOP56_RS22050 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GOP56_RS22055 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GOP56_RS22060 ENOG4105DFU Cell wall formation (By similarity) GOP56_RS22065 ENOG4106A3R peptidase GOP56_RS22080 ENOG4108Z03 MAF-like protein GOP56_RS22085 ENOG4105W5Q DNA repair protein (RadC GOP56_RS22090 ENOG4105DFF Rod shape-determining protein mreb GOP56_RS22095 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) GOP56_RS22105 ENOG4107RF6 penicillin-binding protein GOP56_RS22110 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) GOP56_RS22115 ENOG4107QMS site-determining protein GOP56_RS22120 ENOG4105CNI cell division protein FtsW GOP56_RS22125 ENOG4105VEQ Cold shock protein GOP56_RS22140 ENOG4105C03 ribonuclease GOP56_RS22145 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GOP56_RS22150 ENOG4105X36 (ribosomal) protein GOP56_RS22155 ENOG4105K46 50S ribosomal protein l27 GOP56_RS22165 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GOP56_RS22175 ENOG41090I5 UPF0735 ACT domain-containing protein GOP56_RS22180 ENOG4105D6E homoserine dehydrogenase GOP56_RS22185 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) GOP56_RS22190 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GOP56_RS22195 ENOG4105CQC Prephenate dehydratase GOP56_RS22200 ENOG4105CM2 brancheD-chain amino acid aminotransferase GOP56_RS22215 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GOP56_RS22220 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic GOP56_RS22230 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) GOP56_RS22250 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) GOP56_RS22255 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GOP56_RS22260 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GOP56_RS22265 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) GOP56_RS22275 ENOG4105VIE preprotein translocase, subunit YajC GOP56_RS22280 ENOG4105NAP GOP56_RS22285 ENOG4105D7N magnesium and cobalt transport protein CorA GOP56_RS22290 ENOG4108QG2 Membrane GOP56_RS22295 ENOG4105CKP Polysaccharide Biosynthesis Protein GOP56_RS22305 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GOP56_RS22310 ENOG4107SBW Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GOP56_RS22315 ENOG41076HS cation diffusion facilitator family transporter GOP56_RS22320 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GOP56_RS22325 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GOP56_RS22330 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GOP56_RS22335 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GOP56_RS22340 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GOP56_RS22345 ENOG4105D4P Coproporphyrinogen iii oxidase GOP56_RS22350 ENOG4105CUT histidyl-tRNA synthetase GOP56_RS22355 ENOG4105C9M aspartyl-trna synthetase GOP56_RS22360 ENOG4105CUZ uba thif-type nad fad binding protein GOP56_RS22375 ENOG4105C3J Cysteine desulfurase GOP56_RS22380 ENOG4105C7H Helicase, RecD TraA family GOP56_RS22390 ENOG41060CR GOP56_RS22400 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GOP56_RS22405 ENOG4105VBH UPF0297 protein GOP56_RS22415 ENOG4105VPH UPF0473 protein GOP56_RS22435 ENOG4105XYU peptidase (U32 family) GOP56_RS22440 ENOG4105CFP Peptidase U32 GOP56_RS22445 ENOG4105DBI uridine monophosphokinase GOP56_RS22450 ENOG4107XRG penicillin-binding protein GOP56_RS22460 ENOG4105C8Q Methyl-accepting chemotaxis GOP56_RS22465 ENOG4105C8J )-transporter GOP56_RS22470 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GOP56_RS22475 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA GOP56_RS22480 ENOG4107Y5K Resolvase GOP56_RS22510 ENOG4105RHY Pfam:UPF0157 GOP56_RS22520 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein GOP56_RS22525 ENOG4105DJ2 Major Facilitator Superfamily GOP56_RS22550 ENOG4108J59 Extracellular solute-binding protein, family 5 GOP56_RS22555 ENOG4108Z86 Glutamine amidotransferase GOP56_RS22560 ENOG4108RYK Nad-dependent epimerase dehydratase GOP56_RS22570 ENOG4105UQX Mate efflux family protein GOP56_RS22575 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GOP56_RS22585 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase GOP56_RS22590 ENOG4105CQW ribosome biogenesis GTPase YqeH GOP56_RS22595 ENOG4105E2X shikimate dehydrogenase GOP56_RS22600 ENOG410812S Rna-binding protein GOP56_RS22605 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GOP56_RS22610 ENOG4108WF2 Metal Dependent Phosphohydrolase GOP56_RS22620 ENOG4105DXX methyltransferase GOP56_RS22635 ENOG4105KQC Competence protein GOP56_RS22640 ENOG4105CAQ asparagine synthetase GOP56_RS22645 ENOG4108UK2 deaminase GOP56_RS22650 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 GOP56_RS22655 ENOG4105EMN RNA polymerase sigma factor GOP56_RS22665 ENOG4105TQK DNA polymerase iii, delta' subunit GOP56_RS22670 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) GOP56_RS22680 ENOG4108ZRV stage ii sporulation protein p GOP56_RS22690 ENOG4105C3U ABC transporter GOP56_RS22695 ENOG4108JQ7 (ABC) transporter GOP56_RS22700 ENOG4105DEF Extracellular solute-binding protein, family 5 GOP56_RS22705 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GOP56_RS22710 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GOP56_RS22720 ENOG4105DC7 peptidase M24 GOP56_RS22725 ENOG41081VB Hydrolase GOP56_RS22730 ENOG4108SUT Major Facilitator Superfamily GOP56_RS22735 ENOG4108NGU Transcriptional regulator GOP56_RS22740 ENOG4105CC5 ABC transporter GOP56_RS22745 ENOG4105CC5 ABC transporter GOP56_RS22750 ENOG4105DIK (ABC) transporter GOP56_RS22755 ENOG4105DSE periplasmic solute binding protein GOP56_RS22765 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GOP56_RS22770 ENOG4105VTR Integrase GOP56_RS22825 ENOG4105KRN Transcriptional regulator, abrb family GOP56_RS22945 ENOG4105EFC phage portal protein HK97 family GOP56_RS22950 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GOP56_RS22975 ENOG41060SN GOP56_RS23075 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GOP56_RS23120 ENOG4105CSA Coproporphyrinogen iii oxidase GOP56_RS23125 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) GOP56_RS23135 ENOG4105CFG Acts as a chaperone (By similarity) GOP56_RS23145 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GOP56_RS23150 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GOP56_RS23155 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GOP56_RS23165 ENOG4105VAW lrga family GOP56_RS23170 ENOG41067MG lrgb family GOP56_RS23195 ENOG4105CPF Cell wall formation (By similarity) GOP56_RS23205 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) GOP56_RS23210 ENOG4105VCC 30S ribosomal protein S21 GOP56_RS23215 ENOG4105KTH gatB Yqey GOP56_RS23220 ENOG4105F7J membrane-bound serine protease GOP56_RS23225 ENOG4105DI5 UPF0365 protein GOP56_RS23235 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)