locus-tag	class	description
CXR27_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CXR27_RS00010	COG0592	DNA-directed DNA polymerase activity
CXR27_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CXR27_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
CXR27_RS00025	COG0187	DNA topoisomerase II activity
CXR27_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CXR27_RS00055	COG2814	Major facilitator Superfamily
CXR27_RS00060	COG2814	Major facilitator Superfamily
CXR27_RS00080	COG1012	belongs to the aldehyde dehydrogenase family
CXR27_RS00095	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CXR27_RS00135	COG2837	iron assimilation
CXR27_RS00155	COG0318	PFAM AMP-dependent synthetase and ligase
CXR27_RS00160	COG1028	Short-chain dehydrogenase reductase Sdr
CXR27_RS00165	COG1960	acyl-CoA dehydrogenase activity
CXR27_RS00170	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CXR27_RS00180	COG0793	Belongs to the peptidase S41A family
CXR27_RS00180	COG4946	Tricorn protease homolog
CXR27_RS00185	COG0018	arginyl-trna synthetase
CXR27_RS00190	COG2807	transmembrane transport
CXR27_RS00200	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CXR27_RS00215	COG3764	Sortase (surface protein transpeptidase)
CXR27_RS00230	COG0515	serine threonine protein kinase
CXR27_RS00235	COG0515	serine threonine protein kinase
CXR27_RS00240	COG0768	penicillin binding
CXR27_RS00255	COG1716	ATPase activity
CXR27_RS00295	COG1064	alcohol dehydrogenase
CXR27_RS00325	COG0384	phenazine biosynthesis protein PhzF
CXR27_RS00330	COG1940	carbohydrate kinase activity
CXR27_RS00335	COG0673	inositol 2-dehydrogenase activity
CXR27_RS00345	COG1172	Belongs to the binding-protein-dependent transport system permease family
CXR27_RS00350	COG1172	Belongs to the binding-protein-dependent transport system permease family
CXR27_RS00370	COG1280	lysine exporter protein (LysE YggA)
CXR27_RS00380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CXR27_RS00390	COG2233	PERMEase
CXR27_RS00420	COG1115	amino acid carrier protein
CXR27_RS00440	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CXR27_RS00465	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CXR27_RS00470	COG1012	belongs to the aldehyde dehydrogenase family
CXR27_RS00475	COG0318	PFAM AMP-dependent synthetase and ligase
CXR27_RS00480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CXR27_RS00485	COG1960	acyl-CoA dehydrogenase activity
CXR27_RS00490	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CXR27_RS00500	COG3657	addiction module killer protein
CXR27_RS00505	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CXR27_RS00510	COG0488	(ABC) transporter
CXR27_RS00515	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXR27_RS00520	COG0022	dehydrogenase e1 component
CXR27_RS00575	COG1522	sequence-specific DNA binding
CXR27_RS00580	COG2086	electron transfer activity
CXR27_RS00585	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CXR27_RS00630	COG1982	Orn Lys Arg decarboxylase major
CXR27_RS00635	COG0583	DNA-binding transcription factor activity
CXR27_RS00640	COG1414	Transcriptional regulator
CXR27_RS00650	COG1119	ATPase activity
CXR27_RS00665	COG0477	Major facilitator Superfamily
CXR27_RS00670	COG2030	dehydratase
CXR27_RS00670	COG1012	belongs to the aldehyde dehydrogenase family
CXR27_RS00680	COG4974	Belongs to the 'phage' integrase family
CXR27_RS00730	COG1846	Transcriptional regulator
CXR27_RS00740	COG1132	(ABC) transporter
CXR27_RS00745	COG1132	(ABC) transporter
CXR27_RS00745	COG2375	cellular response to nickel ion
CXR27_RS00750	COG1120	ATPase activity
CXR27_RS00755	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXR27_RS00760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXR27_RS00765	COG4607	ABC-type enterochelin transport system periplasmic component
CXR27_RS00775	COG0738	Major facilitator superfamily
CXR27_RS00790	COG1309	transcriptional regulator
CXR27_RS00815	COG2801	Transposase and inactivated derivatives
CXR27_RS00825	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CXR27_RS00830	COG3386	PFAM SMP-30 Gluconolaconase
CXR27_RS00835	COG1309	transcriptional regulator
CXR27_RS00850	COG3396	Phenylacetate-CoA oxygenase
CXR27_RS00855	COG3460	Phenylacetate-CoA oxygenase
CXR27_RS00860	COG3396	Phenylacetate-CoA oxygenase
CXR27_RS00865	COG2151	metal-sulfur cluster biosynthetic enzyme
CXR27_RS00870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CXR27_RS00880	COG1024	Enoyl-CoA hydratase
CXR27_RS00885	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXR27_RS00890	COG1024	Enoyl-CoA hydratase
CXR27_RS00895	COG1388	LysM domain
CXR27_RS00920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CXR27_RS00935	COG1473	amidohydrolase
CXR27_RS00940	COG1063	alcohol dehydrogenase
CXR27_RS00970	COG0318	PFAM AMP-dependent synthetase and ligase
CXR27_RS00975	COG1028	Short-chain dehydrogenase reductase Sdr
CXR27_RS00980	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CXR27_RS00990	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CXR27_RS00990	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CXR27_RS00995	COG1028	Short-chain dehydrogenase reductase Sdr
CXR27_RS01035	COG3619	membrane
CXR27_RS01040	COG0405	Gamma-glutamyltransferase
CXR27_RS01050	COG0251	oxidation-reduction process
CXR27_RS01070	COG0531	amino acid
CXR27_RS01080	COG0179	Fumarylacetoacetate (FAA) hydrolase
CXR27_RS01090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXR27_RS01095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CXR27_RS01100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXR27_RS01125	COG0431	NADPH-dependent FMN reductase
CXR27_RS01155	COG0277	FAD linked oxidase domain protein
CXR27_RS01165	COG1063	alcohol dehydrogenase
CXR27_RS01175	COG3639	organic phosphonate transmembrane transporter activity
CXR27_RS01180	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CXR27_RS01185	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CXR27_RS01190	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CXR27_RS01195	COG2188	Transcriptional regulator
CXR27_RS01200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CXR27_RS01205	COG1028	Short-chain dehydrogenase reductase Sdr
CXR27_RS01215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CXR27_RS01260	COG2409	Drug exporters of the RND superfamily
CXR27_RS01300	COG0251	oxidation-reduction process
CXR27_RS01315	COG0657	acetylesterase activity
CXR27_RS01330	COG0667	Aldo Keto reductase
CXR27_RS01390	COG1802	Transcriptional regulator
CXR27_RS01395	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXR27_RS01400	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CXR27_RS01400	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CXR27_RS01405	COG1960	acyl-CoA dehydrogenase activity
CXR27_RS01410	COG1960	acyl-CoA dehydrogenase activity
CXR27_RS01415	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
CXR27_RS01420	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXR27_RS01465	COG3104	oligopeptide transport
CXR27_RS01470	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CXR27_RS01500	COG0531	amino acid
CXR27_RS01520	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CXR27_RS01525	COG1012	belongs to the aldehyde dehydrogenase family
CXR27_RS01545	COG0251	oxidation-reduction process
CXR27_RS01555	COG2072	flavoprotein involved in K transport
CXR27_RS01560	COG1027	Aspartate ammonia-lyase
CXR27_RS01610	COG2801	Transposase and inactivated derivatives
CXR27_RS01635	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CXR27_RS01670	COG0477	Major facilitator Superfamily
CXR27_RS01675	COG0251	oxidation-reduction process
CXR27_RS01680	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CXR27_RS01685	COG0702	epimerase
CXR27_RS01700	COG0436	Aminotransferase
CXR27_RS01705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXR27_RS01725	COG1012	belongs to the aldehyde dehydrogenase family
CXR27_RS01740	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CXR27_RS01745	COG0583	DNA-binding transcription factor activity
CXR27_RS01750	COG0477	Major facilitator Superfamily
CXR27_RS01755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CXR27_RS01760	COG0154	amidase activity
CXR27_RS01785	COG2610	gluconate transmembrane transporter activity
CXR27_RS01810	COG1349	DNA-binding transcription factor activity
CXR27_RS01815	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CXR27_RS01820	COG0667	Aldo Keto reductase
CXR27_RS01825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXR27_RS01845	COG1757	Na H antiporter
CXR27_RS01850	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CXR27_RS01855	COG1960	acyl-CoA dehydrogenase activity
CXR27_RS01885	COG4638	Rieske (2fe-2S)
CXR27_RS01890	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CXR27_RS01900	COG1028	Short-chain dehydrogenase reductase Sdr
CXR27_RS01910	COG3485	protocatechuate 3,4-dioxygenase
CXR27_RS01915	COG4948	Mandelate Racemase Muconate Lactonizing
CXR27_RS01920	COG0583	DNA-binding transcription factor activity
CXR27_RS01930	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CXR27_RS01955	COG0318	PFAM AMP-dependent synthetase and ligase
CXR27_RS01960	COG1228	amidohydrolase
CXR27_RS01965	COG2986	histidine ammonia-lyase
CXR27_RS01970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CXR27_RS01985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CXR27_RS02010	COG0180	Tryptophanyl-tRNA synthetase
CXR27_RS02015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CXR27_RS02075	COG1321	iron dependent repressor
CXR27_RS02105	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CXR27_RS02130	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CXR27_RS02145	COG1414	Transcriptional regulator
CXR27_RS02150	COG1414	Transcriptional regulator
CXR27_RS02160	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CXR27_RS02165	COG0833	amino acid
CXR27_RS02170	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CXR27_RS02175	COG0569	domain protein
CXR27_RS02210	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CXR27_RS02215	COG2318	DinB family
CXR27_RS02225	COG0589	response to stress
CXR27_RS02230	COG0247	lactate metabolic process
CXR27_RS02230	COG0277	FAD linked oxidase domain protein
CXR27_RS02240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CXR27_RS02280	COG1960	acyl-CoA dehydrogenase activity
CXR27_RS02285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXR27_RS02290	COG0583	DNA-binding transcription factor activity
CXR27_RS02300	COG1028	Short-chain dehydrogenase reductase Sdr
CXR27_RS02330	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CXR27_RS02330	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CXR27_RS02335	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CXR27_RS02340	COG0509	glycine decarboxylation via glycine cleavage system
CXR27_RS02350	COG0456	acetyltransferase
CXR27_RS02355	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CXR27_RS02360	COG1917	Cupin 2, conserved barrel domain protein
CXR27_RS02375	COG1115	amino acid carrier protein
CXR27_RS02380	COG0584	glycerophosphoryl diester phosphodiesterase
CXR27_RS02395	COG1331	Highly conserved protein containing a thioredoxin domain
CXR27_RS02410	COG3328	transposase activity
CXR27_RS02430	COG1362	aminopeptidase activity
CXR27_RS02440	COG3590	peptidase
CXR27_RS02445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CXR27_RS02465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CXR27_RS02475	COG0583	DNA-binding transcription factor activity
CXR27_RS02505	COG2814	Major facilitator Superfamily
CXR27_RS02510	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CXR27_RS02515	COG0277	FAD linked oxidase domain protein
CXR27_RS02530	COG1316	TRANSCRIPTIONal
CXR27_RS02550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CXR27_RS02550	COG0425	Belongs to the sulfur carrier protein TusA family
CXR27_RS02570	COG1388	LysM domain
CXR27_RS02570	COG1134	teichoic acid transport
CXR27_RS02595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CXR27_RS02600	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CXR27_RS02605	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CXR27_RS02610	COG1215	transferase activity, transferring glycosyl groups
CXR27_RS02615	COG1086	Polysaccharide biosynthesis protein
CXR27_RS02620	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CXR27_RS02625	COG0438	transferase activity, transferring glycosyl groups
CXR27_RS02635	COG1682	transport, permease protein
CXR27_RS02640	COG1134	teichoic acid transport
CXR27_RS02695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CXR27_RS02695	COG0189	ligase activity
CXR27_RS02745	COG2353	YceI-like domain
CXR27_RS02750	COG0477	Major facilitator Superfamily
CXR27_RS02760	COG1301	dicarboxylic acid transport
CXR27_RS02770	COG3290	protein histidine kinase activity
CXR27_RS02775	COG0745	RESPONSE REGULATOR receiver
CXR27_RS02840	COG0596	Alpha beta hydrolase
CXR27_RS02845	COG2130	NADP-dependent
CXR27_RS02895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXR27_RS02915	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CXR27_RS02920	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CXR27_RS02925	COG2249	NAD(P)H dehydrogenase (quinone) activity
CXR27_RS02965	COG2186	Transcriptional regulator
CXR27_RS02970	COG0363	glucosamine-6-phosphate deaminase activity
CXR27_RS02975	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CXR27_RS02980	COG1940	carbohydrate kinase activity
CXR27_RS02985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXR27_RS02990	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CXR27_RS03030	COG0640	Transcriptional regulator
CXR27_RS03035	COG1902	pentaerythritol trinitrate reductase activity
CXR27_RS03050	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CXR27_RS03065	COG1028	Short-chain dehydrogenase reductase Sdr
CXR27_RS03075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXR27_RS03085	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CXR27_RS03120	COG0640	Transcriptional regulator
CXR27_RS03125	COG0640	Transcriptional regulator
CXR27_RS03135	COG2207	Transcriptional regulator
CXR27_RS03175	COG0477	Major facilitator Superfamily
CXR27_RS03215	COG0596	Alpha beta hydrolase
CXR27_RS03240	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CXR27_RS03245	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CXR27_RS03250	COG3119	arylsulfatase activity
CXR27_RS03275	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CXR27_RS03280	COG1054	Belongs to the UPF0176 family
CXR27_RS03285	COG1090	epimerase
CXR27_RS03330	COG3328	transposase activity
CXR27_RS03340	COG0047	phosphoribosylformylglycinamidine synthase activity
CXR27_RS03345	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CXR27_RS03350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXR27_RS03355	COG1177	transmembrane transport
CXR27_RS03360	COG1176	ABC-type spermidine putrescine transport system, permease component I
CXR27_RS03370	COG3842	ATPase activity
CXR27_RS03385	COG0151	Belongs to the GarS family
CXR27_RS03425	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CXR27_RS03455	COG0697	spore germination
CXR27_RS03460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXR27_RS03475	COG0572	uridine kinase
CXR27_RS03510	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CXR27_RS03515	COG1012	belongs to the aldehyde dehydrogenase family
CXR27_RS03530	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CXR27_RS03535	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CXR27_RS03550	COG0300	oxidoreductase activity
CXR27_RS03570	COG0477	Major facilitator Superfamily
CXR27_RS03580	COG3226	Transcriptional regulator
CXR27_RS03595	COG1012	belongs to the aldehyde dehydrogenase family
CXR27_RS03610	COG0667	Aldo Keto reductase
CXR27_RS03615	COG2375	cellular response to nickel ion
CXR27_RS03615	COG1132	(ABC) transporter
CXR27_RS03620	COG2375	cellular response to nickel ion
CXR27_RS03620	COG1132	(ABC) transporter
CXR27_RS03625	COG1129	ABC transporter
CXR27_RS03640	COG0583	DNA-binding transcription factor activity
CXR27_RS03645	COG0477	Major facilitator Superfamily
CXR27_RS03650	COG1960	acyl-CoA dehydrogenase activity
CXR27_RS03655	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXR27_RS03685	COG1132	(ABC) transporter
CXR27_RS03690	COG2239	Acts as a magnesium transporter
CXR27_RS03710	COG0300	oxidoreductase activity
CXR27_RS03740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CXR27_RS03745	COG1739	Uncharacterized protein family UPF0029
CXR27_RS03770	COG3938	Belongs to the proline racemase family
CXR27_RS03775	COG0477	Major facilitator Superfamily
CXR27_RS03780	COG2814	Major facilitator Superfamily
CXR27_RS03785	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CXR27_RS03790	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CXR27_RS03795	COG3485	protocatechuate 3,4-dioxygenase
CXR27_RS03800	COG3485	protocatechuate 3,4-dioxygenase
CXR27_RS03830	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CXR27_RS03865	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CXR27_RS03895	COG2357	RelA SpoT domain protein
CXR27_RS03905	COG1414	Transcriptional regulator
CXR27_RS03915	COG2814	Major facilitator Superfamily
CXR27_RS03935	COG3842	ATPase activity
CXR27_RS03955	COG2188	Transcriptional regulator
CXR27_RS03960	COG1012	belongs to the aldehyde dehydrogenase family
CXR27_RS03995	COG0477	Major facilitator Superfamily
CXR27_RS04005	COG1802	Transcriptional regulator
CXR27_RS04010	COG1012	belongs to the aldehyde dehydrogenase family
CXR27_RS04020	COG3971	2-oxopent-4-enoate hydratase activity
CXR27_RS04065	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CXR27_RS04075	COG0590	tRNA wobble adenosine to inosine editing
CXR27_RS04085	COG2252	PERMEase
CXR27_RS04105	COG0402	S-adenosylhomocysteine deaminase activity
CXR27_RS04110	COG2233	PERMEase
CXR27_RS04115	COG3622	Belongs to the hyi family
CXR27_RS04120	COG2084	Dehydrogenase
CXR27_RS04125	COG3960	tartronate-semialdehyde synthase activity
CXR27_RS04130	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CXR27_RS04145	COG1929	Belongs to the glycerate kinase type-1 family
CXR27_RS04170	COG1414	Transcriptional regulator
CXR27_RS04190	COG0579	oxidoreductase
CXR27_RS04195	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CXR27_RS04200	COG0277	FAD linked oxidase domain protein
CXR27_RS04210	COG2040	homocysteine
CXR27_RS04215	COG0343	queuine tRNA-ribosyltransferase activity
CXR27_RS04225	COG0339	signal peptide processing
CXR27_RS04230	COG0628	permease
CXR27_RS04280	COG0492	ferredoxin-NADP+ reductase activity
CXR27_RS04285	COG2890	protein-(glutamine-N5) methyltransferase activity
CXR27_RS04295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CXR27_RS04305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXR27_RS04335	COG0542	response to heat
CXR27_RS04350	COG0740	serine-type endopeptidase activity
CXR27_RS04355	COG0740	serine-type endopeptidase activity
CXR27_RS04360	COG4585	Histidine kinase
CXR27_RS04365	COG2197	response regulator
CXR27_RS04380	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CXR27_RS04400	COG0577	efflux transmembrane transporter activity
CXR27_RS04400	COG1136	(ABC) transporter
CXR27_RS04425	COG0693	protein deglycase activity
CXR27_RS04450	COG1120	ATPase activity
CXR27_RS04455	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXR27_RS04460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXR27_RS04495	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CXR27_RS04510	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CXR27_RS04555	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CXR27_RS04565	COG3655	Transcriptional regulator
CXR27_RS04585	COG1121	(ABC) transporter
CXR27_RS04595	COG1408	metallophosphoesterase
CXR27_RS04600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CXR27_RS04615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CXR27_RS04630	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CXR27_RS04655	COG1309	transcriptional regulator
CXR27_RS04665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CXR27_RS04715	COG1111	helicase
CXR27_RS04715	COG1205	dead DEAH box helicase
CXR27_RS04725	COG1754	DNA topoisomerase type I activity
CXR27_RS04725	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CXR27_RS04735	COG0456	acetyltransferase
CXR27_RS04745	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CXR27_RS04775	COG1484	DNA-dependent DNA replication
CXR27_RS04780	COG4584	PFAM Integrase catalytic
CXR27_RS04810	COG3344	reverse transcriptase
CXR27_RS04845	COG0183	Belongs to the thiolase family
CXR27_RS04850	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXR27_RS04850	COG1024	Enoyl-CoA hydratase
CXR27_RS04855	COG0604	alcohol dehydrogenase
CXR27_RS04860	COG1309	transcriptional regulator
CXR27_RS04865	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CXR27_RS04875	COG1960	acyl-CoA dehydrogenase activity
CXR27_RS04880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXR27_RS04890	COG0640	Transcriptional regulator
CXR27_RS04900	COG2030	dehydratase
CXR27_RS04910	COG0242	peptide deformylase activity
CXR27_RS04920	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CXR27_RS04930	COG0477	Major facilitator Superfamily
CXR27_RS04935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CXR27_RS04960	COG2027	D-alanyl-D-alanine carboxypeptidase
CXR27_RS04970	COG0037	tRNA processing
CXR27_RS04975	COG0402	S-adenosylhomocysteine deaminase activity
CXR27_RS04980	COG2807	transmembrane transport
CXR27_RS04985	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CXR27_RS04990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CXR27_RS04995	COG0302	gtp cyclohydrolase
CXR27_RS05005	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CXR27_RS05030	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CXR27_RS05050	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CXR27_RS05055	COG1194	a g-specific adenine glycosylase
CXR27_RS05070	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CXR27_RS05090	COG1012	belongs to the aldehyde dehydrogenase family
CXR27_RS05100	COG0583	DNA-binding transcription factor activity
CXR27_RS05125	COG1122	ATPase activity
CXR27_RS05130	COG4721	ABC-type cobalt transport system, permease component
CXR27_RS05155	COG2079	MmgE PrpD family protein
CXR27_RS05160	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CXR27_RS05170	COG1024	Enoyl-CoA hydratase
CXR27_RS05175	COG0248	Ppx GppA phosphatase
CXR27_RS05180	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CXR27_RS05185	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CXR27_RS05190	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CXR27_RS05200	COG1082	Xylose isomerase domain protein TIM barrel
CXR27_RS05205	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CXR27_RS05210	COG2197	response regulator
CXR27_RS05220	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CXR27_RS05235	COG0569	domain protein
CXR27_RS05240	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CXR27_RS05245	COG0123	including yeast histone deacetylase and acetoin utilization protein
CXR27_RS05260	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CXR27_RS05265	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CXR27_RS05275	COG0113	porphobilinogen synthase activity
CXR27_RS05285	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CXR27_RS05290	COG0406	alpha-ribazole phosphatase activity
CXR27_RS05300	COG0785	Cytochrome C biogenesis protein
CXR27_RS05305	COG1333	cytochrome c biogenesis protein
CXR27_RS05310	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CXR27_RS05335	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CXR27_RS05340	COG4948	Mandelate Racemase Muconate Lactonizing
CXR27_RS05355	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CXR27_RS05365	COG1169	isochorismate synthase
CXR27_RS05370	COG2226	methyltransferase
CXR27_RS05380	COG0142	geranyltranstransferase activity
CXR27_RS05385	COG0701	Predicted permease
CXR27_RS05395	COG1131	(ABC) transporter
CXR27_RS05420	COG2357	RelA SpoT domain protein
CXR27_RS05430	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CXR27_RS05450	COG1473	amidohydrolase
CXR27_RS05460	COG0584	glycerophosphoryl diester phosphodiesterase
CXR27_RS05495	COG3328	transposase activity
CXR27_RS05510	COG4221	oxidoreductase activity
CXR27_RS05515	COG1309	transcriptional regulator
CXR27_RS05530	COG3547	Transposase (IS116 IS110 IS902 family)
CXR27_RS05550	COG2372	response to copper ion
CXR27_RS05550	COG1276	copper resistance
CXR27_RS05575	COG1129	ABC transporter
CXR27_RS05580	COG2801	Transposase and inactivated derivatives
CXR27_RS05585	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CXR27_RS05590	COG0431	NADPH-dependent FMN reductase
CXR27_RS05595	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CXR27_RS05600	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CXR27_RS05605	COG1780	Probably involved in ribonucleotide reductase function
CXR27_RS05615	COG1121	(ABC) transporter
CXR27_RS05620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CXR27_RS05630	COG1321	iron dependent repressor
CXR27_RS05680	COG3328	transposase activity
CXR27_RS05700	COG1484	DNA-dependent DNA replication
CXR27_RS05720	COG2801	Transposase and inactivated derivatives
CXR27_RS05725	COG4974	Belongs to the 'phage' integrase family
CXR27_RS05780	COG1136	(ABC) transporter
CXR27_RS05785	COG0577	efflux transmembrane transporter activity
CXR27_RS05785	COG1136	(ABC) transporter
CXR27_RS05865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CXR27_RS05875	COG2801	Transposase and inactivated derivatives
CXR27_RS05885	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
CXR27_RS05920	COG2801	Transposase and inactivated derivatives
CXR27_RS05960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CXR27_RS05965	COG0805	protein transport
CXR27_RS05980	COG0656	L-ascorbic acid biosynthetic process
CXR27_RS05990	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CXR27_RS05995	COG0175	sulfate reduction
CXR27_RS06005	COG0529	Catalyzes the synthesis of activated sulfate
CXR27_RS06005	COG2895	sulfate adenylyltransferase (ATP) activity
CXR27_RS06010	COG1648	precorrin-2 dehydrogenase activity
CXR27_RS06010	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CXR27_RS06025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXR27_RS06045	COG2030	dehydratase
CXR27_RS06055	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CXR27_RS06075	COG0250	Participates in transcription elongation, termination and antitermination
CXR27_RS06080	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CXR27_RS06085	COG0081	regulation of translation
CXR27_RS06105	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CXR27_RS06110	COG0222	ribosome binding
CXR27_RS06140	COG0085	RNA polymerase activity
CXR27_RS06145	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CXR27_RS06160	COG0463	Glycosyl transferase, family 2
CXR27_RS06165	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CXR27_RS06170	COG0745	RESPONSE REGULATOR receiver
CXR27_RS06175	COG2205	protein histidine kinase activity
CXR27_RS06185	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CXR27_RS06195	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CXR27_RS06200	COG0049	tRNA binding
CXR27_RS06205	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CXR27_RS06210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CXR27_RS06215	COG0051	transcription antitermination factor activity, RNA binding
CXR27_RS06220	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CXR27_RS06225	COG0088	Forms part of the polypeptide exit tunnel
CXR27_RS06230	COG0089	rRNA binding
CXR27_RS06235	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CXR27_RS06240	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CXR27_RS06245	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CXR27_RS06250	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CXR27_RS06255	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CXR27_RS06260	COG0255	Belongs to the universal ribosomal protein uL29 family
CXR27_RS06265	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CXR27_RS06270	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CXR27_RS06275	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CXR27_RS06280	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CXR27_RS06285	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CXR27_RS06290	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CXR27_RS06295	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CXR27_RS06300	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CXR27_RS06305	COG1841	ribosomal large subunit assembly
CXR27_RS06310	COG0200	Binds to the 23S rRNA
CXR27_RS06320	COG0563	adenylate kinase activity
CXR27_RS06350	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CXR27_RS06355	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CXR27_RS06360	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CXR27_RS06365	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CXR27_RS06370	COG0202	RNA polymerase activity
CXR27_RS06375	COG0203	ribosomal protein L17
CXR27_RS06380	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CXR27_RS06410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CXR27_RS06415	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CXR27_RS06430	COG0180	Tryptophanyl-tRNA synthetase
CXR27_RS06455	COG1960	acyl-CoA dehydrogenase activity
CXR27_RS06490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CXR27_RS06515	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CXR27_RS06530	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CXR27_RS06535	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CXR27_RS06540	COG0747	negative chemotaxis
CXR27_RS06550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXR27_RS06560	COG0154	amidase activity
CXR27_RS06585	COG0138	bifunctional purine biosynthesis protein purh
CXR27_RS06615	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CXR27_RS06620	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CXR27_RS06625	COG2267	carboxylic ester hydrolase activity
CXR27_RS06630	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CXR27_RS06635	COG0193	aminoacyl-tRNA hydrolase activity
CXR27_RS06670	COG0148	phosphopyruvate hydratase activity
CXR27_RS06700	COG1252	NADH dehydrogenase
CXR27_RS06710	COG1733	regulation of RNA biosynthetic process
CXR27_RS06740	COG2326	polyphosphate kinase activity
CXR27_RS06765	COG2149	membrane
CXR27_RS06770	COG1914	H( )-stimulated, divalent metal cation uptake system
CXR27_RS06780	COG1643	Atp-dependent helicase
CXR27_RS06790	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CXR27_RS06795	COG1260	myo-inositol-1-phosphate synthase
CXR27_RS06800	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CXR27_RS06810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXR27_RS06855	COG1757	Na H antiporter
CXR27_RS06860	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CXR27_RS06865	COG4608	Belongs to the ABC transporter superfamily
CXR27_RS06870	COG0444	Belongs to the ABC transporter superfamily
CXR27_RS06875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXR27_RS06880	COG0601	transmembrane transport
CXR27_RS06885	COG4166	transmembrane transport
CXR27_RS06895	COG0583	DNA-binding transcription factor activity
CXR27_RS06910	COG0318	PFAM AMP-dependent synthetase and ligase
CXR27_RS06950	COG3485	protocatechuate 3,4-dioxygenase
CXR27_RS06960	COG1349	DNA-binding transcription factor activity
CXR27_RS06965	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CXR27_RS06970	COG3395	kinase activity
CXR27_RS06975	COG2610	gluconate transmembrane transporter activity
CXR27_RS06980	COG2217	Heavy metal translocating P-type atpase
CXR27_RS06990	COG0028	Belongs to the TPP enzyme family
CXR27_RS07005	COG1063	alcohol dehydrogenase
CXR27_RS07015	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CXR27_RS07025	COG1301	dicarboxylic acid transport
CXR27_RS07030	COG5285	phytanoyl-CoA dioxygenase
CXR27_RS07060	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CXR27_RS07065	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CXR27_RS07100	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXR27_RS07105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CXR27_RS07110	COG1024	Enoyl-CoA hydratase
CXR27_RS07125	COG3327	negative regulation of DNA-templated transcription, initiation
CXR27_RS07135	COG1484	DNA-dependent DNA replication
CXR27_RS07165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXR27_RS07170	COG1126	abc transporter atp-binding protein
CXR27_RS07175	COG0765	amino acid transport
CXR27_RS07195	COG0019	diaminopimelate decarboxylase activity
CXR27_RS07200	COG1757	Na H antiporter
CXR27_RS07205	COG2197	response regulator
CXR27_RS07210	COG4585	Histidine kinase
CXR27_RS07230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CXR27_RS07235	COG3173	Aminoglycoside phosphotransferase
CXR27_RS07265	COG0783	Belongs to the Dps family
CXR27_RS07270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXR27_RS07290	COG0438	transferase activity, transferring glycosyl groups
CXR27_RS07305	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CXR27_RS07305	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CXR27_RS07335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CXR27_RS07350	COG4585	Histidine kinase
CXR27_RS07355	COG2197	response regulator
CXR27_RS07365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CXR27_RS07390	COG1285	pathogenesis
CXR27_RS07415	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CXR27_RS07430	COG2814	Major facilitator Superfamily
CXR27_RS07435	COG2814	Major facilitator Superfamily
CXR27_RS07440	COG1953	Uracil, thiamine, allantoin
CXR27_RS07450	COG1802	Transcriptional regulator
CXR27_RS07460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CXR27_RS07470	COG2814	Major facilitator Superfamily
CXR27_RS07495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CXR27_RS07510	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CXR27_RS07520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CXR27_RS07520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CXR27_RS07545	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CXR27_RS07560	COG0791	NLP P60 protein
CXR27_RS07565	COG1482	cell wall glycoprotein biosynthetic process
CXR27_RS07585	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
CXR27_RS07585	COG0778	Nitroreductase
CXR27_RS07615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CXR27_RS07620	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CXR27_RS07645	COG0714	Associated with various cellular activities
CXR27_RS07665	COG0745	RESPONSE REGULATOR receiver
CXR27_RS07670	COG5002	protein histidine kinase activity
CXR27_RS07670	COG5000	phosphorelay sensor kinase activity
CXR27_RS07675	COG5401	PFAM Sporulation and spore germination
CXR27_RS07685	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CXR27_RS07695	COG2197	response regulator
CXR27_RS07715	COG0653	protein targeting
CXR27_RS07760	COG2902	Dehydrogenase
CXR27_RS07790	COG4941	Belongs to the sigma-70 factor family
CXR27_RS07795	COG4770	biotin carboxylase activity
CXR27_RS07800	COG0424	maF-like protein
CXR27_RS07815	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CXR27_RS07825	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CXR27_RS07840	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CXR27_RS07845	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CXR27_RS07850	COG0114	fumarate hydratase activity
CXR27_RS07870	COG1722	exodeoxyribonuclease VII activity
CXR27_RS07875	COG1570	exodeoxyribonuclease VII activity
CXR27_RS07880	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CXR27_RS07885	COG1322	Protein conserved in bacteria
CXR27_RS07890	COG0012	GTP binding
CXR27_RS07900	COG0277	FAD linked oxidase domain protein
CXR27_RS07915	COG0582	viral genome integration into host DNA
CXR27_RS07925	COG4974	Belongs to the 'phage' integrase family
CXR27_RS07950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXR27_RS07955	COG1120	ATPase activity
CXR27_RS08035	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXR27_RS08050	COG4716	Myosin-crossreactive antigen
CXR27_RS08080	COG2824	Alkylphosphonate utilization operon protein PhnA
CXR27_RS08155	COG1966	Carbon starvation protein
CXR27_RS08195	COG0702	epimerase
CXR27_RS08220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CXR27_RS08245	COG1122	ATPase activity
CXR27_RS08275	COG1435	thymidine kinase activity
CXR27_RS08295	COG2022	thiamine diphosphate biosynthetic process
CXR27_RS08305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXR27_RS08305	COG2022	thiamine diphosphate biosynthetic process
CXR27_RS08310	COG0352	thiamine-phosphate diphosphorylase activity
CXR27_RS08315	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CXR27_RS08330	COG4585	Histidine kinase
CXR27_RS08335	COG2197	response regulator
CXR27_RS08340	COG3177	Filamentation induced by cAMP protein fic
CXR27_RS08350	COG0833	amino acid
CXR27_RS08360	COG0494	nUDIX hydrolase
CXR27_RS08370	COG0596	Alpha beta hydrolase
CXR27_RS08385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXR27_RS08390	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXR27_RS08395	COG1120	ATPase activity
CXR27_RS08400	COG2354	Protein conserved in bacteria
CXR27_RS08450	COG2318	DinB family
CXR27_RS08460	COG0737	Belongs to the 5'-nucleotidase family
CXR27_RS08465	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CXR27_RS08470	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CXR27_RS08480	COG0492	ferredoxin-NADP+ reductase activity
CXR27_RS08515	COG3012	SEC-C Motif Domain Protein
CXR27_RS08525	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CXR27_RS08540	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CXR27_RS08545	COG0433	COG0433 Predicted ATPase
CXR27_RS08550	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CXR27_RS08560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXR27_RS08575	COG5416	Lipopolysaccharide assembly protein A domain
CXR27_RS08580	COG2838	Isocitrate dehydrogenase
CXR27_RS08585	COG1435	thymidine kinase activity
CXR27_RS08595	COG0471	metal ion transport
CXR27_RS08600	COG1902	pentaerythritol trinitrate reductase activity
CXR27_RS08605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CXR27_RS08620	COG0601	transmembrane transport
CXR27_RS08625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXR27_RS08635	COG1217	gtp-binding protein TYPA
CXR27_RS08640	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CXR27_RS08645	COG2720	vancomycin resistance protein
CXR27_RS08680	COG1611	Belongs to the LOG family
CXR27_RS08710	COG2801	Transposase and inactivated derivatives
CXR27_RS08735	COG2239	Acts as a magnesium transporter
CXR27_RS08750	COG0006	proline dipeptidase activity
CXR27_RS08760	COG0513	Belongs to the DEAD box helicase family
CXR27_RS08775	COG1309	transcriptional regulator
CXR27_RS08825	COG3480	Lon protease (S16) C-terminal proteolytic domain
CXR27_RS08830	COG1615	UPF0182 protein
CXR27_RS08835	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CXR27_RS08855	COG2353	YceI-like domain
CXR27_RS08865	COG0483	inositol monophosphate 1-phosphatase activity
CXR27_RS08875	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CXR27_RS08885	COG1595	DNA-templated transcription, initiation
CXR27_RS08900	COG0567	Dehydrogenase, E1 component
CXR27_RS08900	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXR27_RS08970	COG1484	DNA-dependent DNA replication
CXR27_RS09015	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CXR27_RS09050	COG1396	sequence-specific DNA binding
CXR27_RS09075	COG0577	efflux transmembrane transporter activity
CXR27_RS09075	COG1136	(ABC) transporter
CXR27_RS09085	COG2807	transmembrane transport
CXR27_RS09090	COG0018	arginyl-trna synthetase
CXR27_RS09090	COG0018	arginyl-trna synthetase
CXR27_RS09095	COG0019	diaminopimelate decarboxylase activity
CXR27_RS09100	COG0460	homoserine dehydrogenase
CXR27_RS09105	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CXR27_RS09110	COG0083	homoserine kinase activity
CXR27_RS09120	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CXR27_RS09135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CXR27_RS09145	COG0356	it plays a direct role in the translocation of protons across the membrane
CXR27_RS09150	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CXR27_RS09155	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CXR27_RS09160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CXR27_RS09165	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CXR27_RS09170	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CXR27_RS09175	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CXR27_RS09180	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CXR27_RS09195	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
CXR27_RS09210	COG0183	Belongs to the thiolase family
CXR27_RS09260	COG1946	Acyl-CoA thioesterase
CXR27_RS09280	COG0668	transmembrane transport
CXR27_RS09290	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CXR27_RS09295	COG0698	ribose 5-phosphate isomerase
CXR27_RS09300	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CXR27_RS09305	COG2133	pyrroloquinoline quinone binding
CXR27_RS09325	COG0544	peptidyl-prolyl cis-trans isomerase activity
CXR27_RS09335	COG0740	serine-type endopeptidase activity
CXR27_RS09340	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CXR27_RS09355	COG0525	valine-tRNA ligase activity
CXR27_RS09375	COG0285	dihydrofolate synthase activity
CXR27_RS09395	COG1530	ribonuclease E activity
CXR27_RS09405	COG1115	amino acid carrier protein
CXR27_RS09410	COG1605	Chorismate mutase
CXR27_RS09410	COG0287	Prephenate dehydrogenase
CXR27_RS09415	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CXR27_RS09420	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CXR27_RS09425	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CXR27_RS09430	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CXR27_RS09435	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CXR27_RS09440	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CXR27_RS09450	COG0799	negative regulation of ribosome biogenesis
CXR27_RS09465	COG2111	Na H antiporter
CXR27_RS09465	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CXR27_RS09470	COG1006	Multisubunit Na H antiporter MnhC subunit
CXR27_RS09475	COG0651	ATP synthesis coupled electron transport
CXR27_RS09480	COG1863	multisubunit Na H antiporter MnhE subunit
CXR27_RS09520	COG2211	Major facilitator Superfamily
CXR27_RS09530	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXR27_RS09535	COG3246	L-lysine catabolic process to acetate
CXR27_RS09540	COG1309	transcriptional regulator
CXR27_RS09550	COG2364	Membrane
CXR27_RS09560	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CXR27_RS09635	COG1950	PFAM Membrane protein of
CXR27_RS09645	COG3104	oligopeptide transport
CXR27_RS09705	COG0318	PFAM AMP-dependent synthetase and ligase
CXR27_RS09710	COG1126	abc transporter atp-binding protein
CXR27_RS09715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXR27_RS09720	COG0765	amino acid transport
CXR27_RS09725	COG0765	amino acid transport
CXR27_RS09735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CXR27_RS09740	COG0438	transferase activity, transferring glycosyl groups
CXR27_RS09790	COG0789	Transcriptional regulator
CXR27_RS09860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CXR27_RS09865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CXR27_RS09880	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CXR27_RS09895	COG0537	adenosine 5'-monophosphoramidase activity
CXR27_RS09900	COG0789	Transcriptional regulator
CXR27_RS09905	COG0626	cystathionine gamma-synthase activity
CXR27_RS09935	COG1309	transcriptional regulator
CXR27_RS09960	COG1136	(ABC) transporter
CXR27_RS09960	COG0577	efflux transmembrane transporter activity
CXR27_RS09975	COG3328	transposase activity
CXR27_RS09980	COG3311	Transcriptional regulator
CXR27_RS09990	COG3328	transposase activity
CXR27_RS10000	COG2353	YceI-like domain
CXR27_RS10010	COG2233	PERMEase
CXR27_RS10015	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CXR27_RS10025	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CXR27_RS10035	COG3022	response to hydroperoxide
CXR27_RS10050	COG1940	carbohydrate kinase activity
CXR27_RS10060	COG1725	Transcriptional regulator
CXR27_RS10075	COG0174	glutamine synthetase
CXR27_RS10080	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CXR27_RS10105	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CXR27_RS10110	COG0321	lipoyl(octanoyl) transferase activity
CXR27_RS10120	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXR27_RS10125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CXR27_RS10130	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CXR27_RS10135	COG0167	dihydroorotate dehydrogenase activity
CXR27_RS10155	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CXR27_RS10160	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CXR27_RS10165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CXR27_RS10185	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CXR27_RS10190	COG0723	plastoquinol--plastocyanin reductase activity
CXR27_RS10195	COG2010	Cytochrome c
CXR27_RS10200	COG1845	cytochrome c oxidase, subunit III
CXR27_RS10205	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CXR27_RS10225	COG0204	Acyl-transferase
CXR27_RS10255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXR27_RS10275	COG1528	Iron-storage protein
CXR27_RS10280	COG2154	pterin-4-alpha-carbinolamine dehydratase
CXR27_RS10325	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CXR27_RS10360	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CXR27_RS10380	COG0463	Glycosyl transferase, family 2
CXR27_RS10390	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CXR27_RS10395	COG0653	protein targeting
CXR27_RS10405	COG0805	protein transport
CXR27_RS10410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CXR27_RS10420	COG2378	regulation of single-species biofilm formation
CXR27_RS10445	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CXR27_RS10450	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CXR27_RS10460	COG4122	O-methyltransferase activity
CXR27_RS10470	COG1222	aaa ATPase
CXR27_RS10500	COG0215	cysteine-tRNA ligase activity
CXR27_RS10520	COG0667	Aldo Keto reductase
CXR27_RS10525	COG1968	undecaprenyl-diphosphatase activity
CXR27_RS10545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CXR27_RS10560	COG2030	dehydratase
CXR27_RS10570	COG0183	Belongs to the thiolase family
CXR27_RS10580	COG1960	acyl-CoA dehydrogenase activity
CXR27_RS10585	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CXR27_RS10595	COG0587	DNA-directed DNA polymerase activity
CXR27_RS10610	COG2226	methyltransferase
CXR27_RS10615	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CXR27_RS10620	COG0351	phosphomethylpyrimidine kinase
CXR27_RS10625	COG0254	rRNA binding
CXR27_RS10665	COG1119	ATPase activity
CXR27_RS10675	COG0560	Phosphoserine phosphatase
CXR27_RS10710	COG0488	(ABC) transporter
CXR27_RS10715	COG0328	RNA-DNA hybrid ribonuclease activity
CXR27_RS10720	COG2151	metal-sulfur cluster biosynthetic enzyme
CXR27_RS10725	COG0822	iron-sulfur transferase activity
CXR27_RS10735	COG0396	ATPase activity
CXR27_RS10780	COG0109	protoheme IX farnesyltransferase activity
CXR27_RS10790	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CXR27_RS10795	COG0166	Belongs to the GPI family
CXR27_RS10800	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CXR27_RS10805	COG0149	triose-phosphate isomerase activity
CXR27_RS10810	COG0126	phosphoglycerate kinase activity
CXR27_RS10815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CXR27_RS10820	COG1481	regulation of sporulation
CXR27_RS10830	COG1660	Displays ATPase and GTPase activities
CXR27_RS10835	COG0322	excinuclease ABC activity
CXR27_RS10860	COG0556	nucleotide-excision repair
CXR27_RS10865	COG0237	dephospho-CoA kinase activity
CXR27_RS10865	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CXR27_RS10875	COG0539	negative regulation of cytoplasmic translation
CXR27_RS10890	COG2050	protein possibly involved in aromatic compounds catabolism
CXR27_RS10910	COG0469	pyruvate kinase activity
CXR27_RS10920	COG0067	glutamate synthase
CXR27_RS10920	COG0069	glutamate synthase activity
CXR27_RS10920	COG0070	glutamate synthase
CXR27_RS10930	COG0159	tryptophan synthase activity
CXR27_RS10935	COG0133	tryptophan synthase activity
CXR27_RS10940	COG0134	indole-3-glycerol-phosphate synthase activity
CXR27_RS10960	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CXR27_RS10965	COG0107	imidazoleglycerol-phosphate synthase activity
CXR27_RS10985	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CXR27_RS10990	COG0140	phosphoribosyl-ATP diphosphatase activity
CXR27_RS10995	COG3201	nicotinamide mononucleotide transporter
CXR27_RS11000	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CXR27_RS11010	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CXR27_RS11020	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CXR27_RS11030	COG1758	RNA polymerase activity
CXR27_RS11035	COG0194	GDP metabolic process
CXR27_RS11040	COG0194	GDP metabolic process
CXR27_RS11045	COG0284	orotidine-5'-phosphate decarboxylase activity
CXR27_RS11050	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CXR27_RS11055	COG0505	Belongs to the CarA family
CXR27_RS11065	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CXR27_RS11070	COG0540	Belongs to the ATCase OTCase family
CXR27_RS11075	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CXR27_RS11080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CXR27_RS11085	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CXR27_RS11090	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CXR27_RS11095	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CXR27_RS11100	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CXR27_RS11110	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CXR27_RS11115	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CXR27_RS11120	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CXR27_RS11125	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CXR27_RS11130	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CXR27_RS11145	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CXR27_RS11150	COG0640	Transcriptional regulator
CXR27_RS11155	COG0124	histidyl-tRNA synthetase
CXR27_RS11165	COG1196	nuclear chromosome segregation
CXR27_RS11175	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CXR27_RS11180	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CXR27_RS11185	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CXR27_RS11195	COG2255	four-way junction helicase activity
CXR27_RS11200	COG0632	four-way junction helicase activity
CXR27_RS11205	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CXR27_RS11210	COG0217	transcriptional regulatory protein
CXR27_RS11220	COG0823	Involved in the tonB-independent uptake of proteins
CXR27_RS11220	COG1506	peptidase
CXR27_RS11220	COG4946	Tricorn protease homolog
CXR27_RS11230	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CXR27_RS11270	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CXR27_RS11280	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CXR27_RS11290	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CXR27_RS11295	COG0484	heat shock protein binding
CXR27_RS11300	COG1420	regulation of RNA biosynthetic process
CXR27_RS11320	COG0481	GTPase activity
CXR27_RS11335	COG0268	Binds directly to 16S ribosomal RNA
CXR27_RS11355	COG1307	EDD domain protein, DegV family
CXR27_RS11360	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CXR27_RS11370	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CXR27_RS11375	COG0495	leucyl-tRNA aminoacylation
CXR27_RS11380	COG1022	Amp-dependent synthetase and ligase
CXR27_RS11385	COG0435	Glutathione S-transferase
CXR27_RS11390	COG0586	Pfam SNARE associated Golgi protein
CXR27_RS11395	COG1295	ribonuclease BN
CXR27_RS11425	COG0358	DNA primase activity
CXR27_RS11430	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CXR27_RS11440	COG0488	(ABC) transporter
CXR27_RS11455	COG0006	proline dipeptidase activity
CXR27_RS11465	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CXR27_RS11475	COG0423	glycine-tRNA ligase activity
CXR27_RS11485	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CXR27_RS11490	COG1381	Involved in DNA repair and RecF pathway recombination
CXR27_RS11495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CXR27_RS11520	COG3739	integral membrane protein
CXR27_RS11535	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CXR27_RS11540	COG2153	protein acetylation
CXR27_RS11545	COG1846	Transcriptional regulator
CXR27_RS11555	COG3253	May function as heme-dependent peroxidase
CXR27_RS11560	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CXR27_RS11565	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CXR27_RS11580	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CXR27_RS11585	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CXR27_RS11600	COG0531	amino acid
CXR27_RS11605	COG0569	domain protein
CXR27_RS11625	COG0756	dUTP diphosphatase activity
CXR27_RS11645	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CXR27_RS11655	COG4988	ABC transporter
CXR27_RS11660	COG1294	oxidase, subunit
CXR27_RS11665	COG1271	oxidase subunit
CXR27_RS11680	COG0187	DNA topoisomerase II activity
CXR27_RS11685	COG0860	N-Acetylmuramoyl-L-alanine amidase
CXR27_RS11690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CXR27_RS11710	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CXR27_RS11715	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CXR27_RS11730	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CXR27_RS11745	COG1799	cell septum assembly
CXR27_RS11755	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CXR27_RS11765	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CXR27_RS11770	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CXR27_RS11780	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CXR27_RS11785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CXR27_RS11790	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CXR27_RS11795	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CXR27_RS11800	COG0768	penicillin binding
CXR27_RS11810	COG0275	rRNA processing
CXR27_RS11815	COG2001	Belongs to the MraZ family
CXR27_RS11820	COG0714	Associated with various cellular activities
CXR27_RS11830	COG1305	Transglutaminase-like
CXR27_RS11850	COG0142	geranyltranstransferase activity
CXR27_RS11860	COG1705	Flagellar rod assembly protein muramidase FlgJ
CXR27_RS11860	COG1388	LysM domain
CXR27_RS11865	COG0515	serine threonine protein kinase
CXR27_RS11865	COG2815	serine threonine protein kinase
CXR27_RS11870	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CXR27_RS11880	COG1716	ATPase activity
CXR27_RS11940	COG0367	asparagine synthase
CXR27_RS11955	COG0156	8-amino-7-oxononanoate synthase activity
CXR27_RS11985	COG1535	isochorismatase
CXR27_RS11985	COG3433	isochorismatase activity
CXR27_RS11990	COG1028	Short-chain dehydrogenase reductase Sdr
CXR27_RS11995	COG1169	isochorismate synthase
CXR27_RS12005	COG1535	isochorismatase
CXR27_RS12005	COG3433	isochorismatase activity
CXR27_RS12020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR27_RS12025	COG2801	Transposase and inactivated derivatives
CXR27_RS12035	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CXR27_RS12045	COG1132	(ABC) transporter
CXR27_RS12055	COG3344	reverse transcriptase
CXR27_RS12070	COG0738	Major facilitator superfamily
CXR27_RS12080	COG0477	Major facilitator Superfamily
CXR27_RS12110	COG0534	Mate efflux family protein
CXR27_RS12125	COG0183	Belongs to the thiolase family
CXR27_RS12160	COG0009	L-threonylcarbamoyladenylate synthase
CXR27_RS12165	COG0628	permease
CXR27_RS12170	COG1160	GTP binding
CXR27_RS12175	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CXR27_RS12190	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CXR27_RS12210	COG0494	nUDIX hydrolase
CXR27_RS12215	COG0504	CTP synthase activity
CXR27_RS12225	COG0438	transferase activity, transferring glycosyl groups
CXR27_RS12250	COG0497	DNA recombination
CXR27_RS12255	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CXR27_RS12270	COG0647	UMP catabolic process
CXR27_RS12285	COG1012	belongs to the aldehyde dehydrogenase family
CXR27_RS12295	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CXR27_RS12320	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CXR27_RS12335	COG0165	Argininosuccinate lyase
CXR27_RS12340	COG1438	arginine binding
CXR27_RS12345	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CXR27_RS12350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CXR27_RS12355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CXR27_RS12360	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CXR27_RS12365	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CXR27_RS12380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CXR27_RS12405	COG1397	ADP-ribosylglycohydrolase
CXR27_RS12450	COG2271	Major facilitator Superfamily
CXR27_RS12455	COG4948	Mandelate Racemase Muconate Lactonizing
CXR27_RS12460	COG0800	Aldolase
CXR27_RS12465	COG3734	2-keto-3-deoxy-galactonokinase
CXR27_RS12470	COG1414	Transcriptional regulator
CXR27_RS12485	COG1484	DNA-dependent DNA replication
CXR27_RS12560	COG4279	zinc finger
CXR27_RS12565	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CXR27_RS12590	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CXR27_RS12595	COG1609	Transcriptional regulator
CXR27_RS12605	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CXR27_RS12630	COG1794	racemase activity, acting on amino acids and derivatives
CXR27_RS12715	COG0072	phenylalanine-tRNA ligase activity
CXR27_RS12715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CXR27_RS12720	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CXR27_RS12745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CXR27_RS12750	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CXR27_RS12755	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CXR27_RS12760	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CXR27_RS12770	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CXR27_RS12785	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CXR27_RS12800	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CXR27_RS12805	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CXR27_RS12815	COG0131	Imidazoleglycerol-phosphate dehydratase
CXR27_RS12820	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CXR27_RS12830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CXR27_RS12840	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CXR27_RS12850	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CXR27_RS12855	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CXR27_RS12865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CXR27_RS12870	COG2137	regulation of response to DNA damage stimulus
CXR27_RS12885	COG1396	sequence-specific DNA binding
CXR27_RS12890	COG1546	Belongs to the CinA family
CXR27_RS12890	COG1058	Belongs to the CinA family
CXR27_RS12900	COG1674	ftsk spoiiie
CXR27_RS12935	COG0745	RESPONSE REGULATOR receiver
CXR27_RS12940	COG3290	protein histidine kinase activity
CXR27_RS12945	COG2851	Citrate transporter
CXR27_RS12955	COG0247	lactate metabolic process
CXR27_RS12960	COG0277	FAD linked oxidase domain protein
CXR27_RS12965	COG0277	FAD linked oxidase domain protein
CXR27_RS12970	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CXR27_RS12980	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CXR27_RS12985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXR27_RS12995	COG1902	pentaerythritol trinitrate reductase activity
CXR27_RS12995	COG0446	pyridine nucleotide-disulphide oxidoreductase
CXR27_RS13015	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CXR27_RS13035	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CXR27_RS13045	COG0612	Peptidase, M16
CXR27_RS13050	COG1185	polyribonucleotide nucleotidyltransferase activity
CXR27_RS13070	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CXR27_RS13080	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CXR27_RS13085	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CXR27_RS13085	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CXR27_RS13100	COG0779	Required for maturation of 30S ribosomal subunits
CXR27_RS13120	COG0442	prolyl-tRNA aminoacylation
CXR27_RS13140	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CXR27_RS13150	COG0750	zinc metalloprotease
CXR27_RS13155	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CXR27_RS13160	COG1960	acyl-CoA dehydrogenase activity
CXR27_RS13165	COG2890	protein-(glutamine-N5) methyltransferase activity
CXR27_RS13180	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CXR27_RS13185	COG0575	Belongs to the CDS family
CXR27_RS13190	COG0233	cytoplasmic translational termination
CXR27_RS13195	COG0528	UMP kinase activity
CXR27_RS13200	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CXR27_RS13205	COG0052	Belongs to the universal ribosomal protein uS2 family
CXR27_RS13215	COG4974	Belongs to the 'phage' integrase family
CXR27_RS13230	COG0792	nuclease activity
CXR27_RS13240	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CXR27_RS13250	COG0681	Belongs to the peptidase S26 family
CXR27_RS13255	COG0335	large ribosomal subunit rRNA binding
CXR27_RS13260	COG0336	Belongs to the RNA methyltransferase TrmD family
CXR27_RS13265	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CXR27_RS13270	COG1837	Belongs to the UPF0109 family
CXR27_RS13275	COG0228	four-way junction DNA binding
CXR27_RS13325	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CXR27_RS13345	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CXR27_RS13350	COG0571	ribonuclease III activity
CXR27_RS13355	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CXR27_RS13380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXR27_RS13385	COG0765	amino acid transport
CXR27_RS13390	COG0765	amino acid transport
CXR27_RS13395	COG1126	abc transporter atp-binding protein
CXR27_RS13405	COG0742	ribosomal rna small subunit methyltransferase
CXR27_RS13415	COG1461	Dihydroxyacetone kinase
CXR27_RS13420	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CXR27_RS13430	COG1181	Belongs to the D-alanine--D-alanine ligase family
CXR27_RS13440	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CXR27_RS13450	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CXR27_RS13455	COG0066	3-isopropylmalate dehydratase activity
CXR27_RS13460	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CXR27_RS13465	COG1414	Transcriptional regulator
CXR27_RS13470	COG1349	DNA-binding transcription factor activity
CXR27_RS13485	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CXR27_RS13495	COG2017	converts alpha-aldose to the beta-anomer
CXR27_RS13520	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CXR27_RS13525	COG0179	Fumarylacetoacetate (FAA) hydrolase
CXR27_RS13530	COG1643	Atp-dependent helicase
CXR27_RS13545	COG0537	adenosine 5'-monophosphoramidase activity
CXR27_RS13560	COG3340	Belongs to the peptidase S51 family
CXR27_RS13575	COG1505	serine-type exopeptidase activity
CXR27_RS13590	COG0477	Major facilitator Superfamily
CXR27_RS13595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CXR27_RS13600	COG0473	3-isopropylmalate dehydrogenase activity
CXR27_RS13615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CXR27_RS13620	COG4552	Acetyltransferase involved in intracellular survival and related
CXR27_RS13625	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CXR27_RS13630	COG0440	acetolactate synthase activity
CXR27_RS13635	COG0028	Belongs to the TPP enzyme family
CXR27_RS13645	COG1132	(ABC) transporter
CXR27_RS13655	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CXR27_RS13705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CXR27_RS13735	COG0129	dihydroxy-acid dehydratase activity
CXR27_RS13740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CXR27_RS13760	COG1045	serine acetyltransferase
CXR27_RS13770	COG0242	peptide deformylase activity
CXR27_RS13780	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CXR27_RS13785	COG0154	amidase activity
CXR27_RS13790	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CXR27_RS13800	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CXR27_RS13815	COG0482	sulfurtransferase activity
CXR27_RS13850	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CXR27_RS13860	COG0659	secondary active sulfate transmembrane transporter activity
CXR27_RS13870	COG2186	Transcriptional regulator
CXR27_RS13875	COG0247	lactate metabolic process
CXR27_RS13880	COG1139	Iron-sulfur cluster binding protein
CXR27_RS13885	COG1556	Lactate utilization protein
CXR27_RS13895	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CXR27_RS13920	COG2066	Belongs to the glutaminase family
CXR27_RS13935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXR27_RS13940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CXR27_RS13945	COG1764	response to oxidative stress
CXR27_RS13990	COG1914	H( )-stimulated, divalent metal cation uptake system
CXR27_RS13995	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CXR27_RS14000	COG4336	lyase activity
CXR27_RS14005	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CXR27_RS14010	COG4770	biotin carboxylase activity
CXR27_RS14045	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CXR27_RS14050	COG0531	amino acid
CXR27_RS14075	COG1607	acyl-coa hydrolase
CXR27_RS14100	COG0477	Major facilitator Superfamily
CXR27_RS14110	COG0589	response to stress
CXR27_RS14115	COG1690	Belongs to the RtcB family
CXR27_RS14130	COG0045	succinate-CoA ligase (ADP-forming) activity
CXR27_RS14160	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CXR27_RS14170	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CXR27_RS14170	COG1473	amidohydrolase
CXR27_RS14180	COG2009	succinate dehydrogenase
CXR27_RS14195	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CXR27_RS14200	COG1686	Belongs to the peptidase S11 family
CXR27_RS14235	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CXR27_RS14240	COG1780	Probably involved in ribonucleotide reductase function
CXR27_RS14250	COG0714	Associated with various cellular activities
CXR27_RS14280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CXR27_RS14300	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CXR27_RS14315	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CXR27_RS14330	COG2884	Cell division ATP-binding protein ftsE
CXR27_RS14335	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CXR27_RS14400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CXR27_RS14405	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CXR27_RS14410	COG0156	8-amino-7-oxononanoate synthase activity
CXR27_RS14415	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CXR27_RS14420	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CXR27_RS14430	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CXR27_RS14445	COG1079	Belongs to the binding-protein-dependent transport system permease family
CXR27_RS14450	COG4603	Belongs to the binding-protein-dependent transport system permease family
CXR27_RS14460	COG1744	ABC transporter substrate-binding protein PnrA-like
CXR27_RS14480	COG0488	(ABC) transporter
CXR27_RS14585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXR27_RS14590	COG1120	ATPase activity
CXR27_RS14625	COG4977	sequence-specific DNA binding
CXR27_RS14625	COG1917	Cupin 2, conserved barrel domain protein
CXR27_RS14665	COG1196	nuclear chromosome segregation
CXR27_RS14665	COG0741	lytic transglycosylase activity
CXR27_RS14665	COG0739	heme binding
CXR27_RS14750	COG1410	methionine synthase
CXR27_RS14750	COG0646	methionine synthase
CXR27_RS14760	COG0477	Major facilitator Superfamily
CXR27_RS14765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CXR27_RS14770	COG3328	transposase activity
CXR27_RS14780	COG2508	Transcriptional regulator
CXR27_RS14780	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CXR27_RS14790	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CXR27_RS14795	COG3265	gluconokinase activity
CXR27_RS14800	COG2610	gluconate transmembrane transporter activity
CXR27_RS14810	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CXR27_RS14815	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CXR27_RS14830	COG0791	NLP P60 protein
CXR27_RS14830	COG1388	LysM domain
CXR27_RS14830	COG3103	Sh3 type 3 domain protein
CXR27_RS14835	COG1472	Belongs to the glycosyl hydrolase 3 family
CXR27_RS14845	COG0395	ABC-type sugar transport system, permease component
CXR27_RS14860	COG2390	Transcriptional regulator
CXR27_RS14865	COG1070	Carbohydrate kinase
CXR27_RS14870	COG3842	ATPase activity
CXR27_RS14875	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CXR27_RS14885	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CXR27_RS14895	COG0667	Aldo Keto reductase
CXR27_RS14905	COG1280	lysine exporter protein (LysE YggA)
CXR27_RS14920	COG0802	atpase or kinase
CXR27_RS14925	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CXR27_RS14940	COG0736	holo-[acyl-carrier-protein] synthase activity
CXR27_RS14945	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CXR27_RS14950	COG1072	(Pantothenic acid kinase))
CXR27_RS14955	COG1132	(ABC) transporter
CXR27_RS14960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CXR27_RS14965	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CXR27_RS14970	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CXR27_RS14985	COG1525	nuclease
CXR27_RS14985	COG4085	toxin activity
CXR27_RS14985	COG0737	Belongs to the 5'-nucleotidase family
CXR27_RS14990	COG2801	Transposase and inactivated derivatives
CXR27_RS14995	COG0101	tRNA pseudouridine synthase activity
CXR27_RS15005	COG0438	transferase activity, transferring glycosyl groups
CXR27_RS15020	COG1122	ATPase activity
CXR27_RS15025	COG1268	BioY protein
CXR27_RS15030	COG0519	Catalyzes the synthesis of GMP from XMP
CXR27_RS15030	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CXR27_RS15045	COG0516	GMP reductase activity
CXR27_RS15100	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CXR27_RS15105	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CXR27_RS15110	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CXR27_RS15115	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CXR27_RS15145	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CXR27_RS15145	COG0352	thiamine-phosphate diphosphorylase activity
CXR27_RS15145	COG0351	phosphomethylpyrimidine kinase
CXR27_RS15150	COG0351	phosphomethylpyrimidine kinase
CXR27_RS15155	COG0352	thiamine-phosphate diphosphorylase activity
CXR27_RS15165	COG4214	carbohydrate transport
CXR27_RS15170	COG1129	ABC transporter
CXR27_RS15175	COG4213	ABC transporter substrate-binding protein
CXR27_RS15190	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CXR27_RS15210	COG0564	pseudouridine synthase activity
CXR27_RS15235	COG0574	Belongs to the PEP-utilizing enzyme family
CXR27_RS15235	COG3848	Pyruvate phosphate dikinase
CXR27_RS15250	COG0577	efflux transmembrane transporter activity
CXR27_RS15255	COG1136	(ABC) transporter
CXR27_RS15260	COG0459	protein refolding
CXR27_RS15265	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CXR27_RS15270	COG3583	domain protein
CXR27_RS15275	COG0084	hydrolase, TatD family'
CXR27_RS15310	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
CXR27_RS15320	COG2089	acid synthase
CXR27_RS15350	COG1216	Glycosyl transferase, family 2
CXR27_RS15380	COG0789	Transcriptional regulator
CXR27_RS15400	COG0494	nUDIX hydrolase
CXR27_RS15540	COG2011	ABC-type metal ion transport system permease component
CXR27_RS15560	COG2367	Beta-lactamase
CXR27_RS15585	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CXR27_RS15590	COG0657	acetylesterase activity
CXR27_RS15605	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CXR27_RS15665	COG4172	Belongs to the ABC transporter superfamily
CXR27_RS15670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXR27_RS15675	COG0601	transmembrane transport
CXR27_RS15690	COG0438	transferase activity, transferring glycosyl groups
CXR27_RS15695	COG0438	transferase activity, transferring glycosyl groups
CXR27_RS15750	COG0601	transmembrane transport
CXR27_RS15765	COG0438	transferase activity, transferring glycosyl groups
CXR27_RS15770	COG0438	transferase activity, transferring glycosyl groups
CXR27_RS15780	COG0438	transferase activity, transferring glycosyl groups
CXR27_RS15800	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CXR27_RS15810	COG0598	Magnesium transport protein CorA
CXR27_RS15830	COG0039	L-malate dehydrogenase activity
CXR27_RS15850	COG1028	Short-chain dehydrogenase reductase Sdr
CXR27_RS15860	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CXR27_RS15880	COG0142	geranyltranstransferase activity
CXR27_RS15900	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CXR27_RS15910	COG0415	Belongs to the DNA photolyase family
CXR27_RS15930	COG0702	epimerase
CXR27_RS15940	COG0702	epimerase
CXR27_RS15960	COG2271	Major facilitator Superfamily
CXR27_RS15970	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CXR27_RS15975	COG0521	Mo-molybdopterin cofactor biosynthetic process
CXR27_RS15990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CXR27_RS16015	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CXR27_RS16025	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CXR27_RS16030	COG0798	PFAM Bile acid sodium symporter
CXR27_RS16050	COG0387	Pfam Sodium calcium exchanger
CXR27_RS16095	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXR27_RS16095	COG1024	Enoyl-CoA hydratase
CXR27_RS16105	COG0697	spore germination
CXR27_RS16125	COG0667	Aldo Keto reductase
CXR27_RS16140	COG2814	Major facilitator Superfamily
CXR27_RS16155	COG1295	ribonuclease BN
CXR27_RS16180	COG0494	nUDIX hydrolase
CXR27_RS16185	COG2818	Glycosylase
CXR27_RS16190	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CXR27_RS16195	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CXR27_RS16200	COG2031	fatty acid transporter
CXR27_RS16205	COG1012	belongs to the aldehyde dehydrogenase family
CXR27_RS16215	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXR27_RS16240	COG0318	PFAM AMP-dependent synthetase and ligase
CXR27_RS16245	COG1024	Enoyl-CoA hydratase
CXR27_RS16265	COG2855	membrane
CXR27_RS16305	COG1063	alcohol dehydrogenase
CXR27_RS16310	COG0477	Major facilitator Superfamily
CXR27_RS16315	COG1414	Transcriptional regulator
CXR27_RS16395	COG0791	NLP P60 protein
CXR27_RS16395	COG1388	LysM domain
CXR27_RS16395	COG3103	Sh3 type 3 domain protein
CXR27_RS16410	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CXR27_RS16420	COG2814	Major facilitator Superfamily
CXR27_RS16430	COG1278	Cold shock
CXR27_RS16445	COG1061	Type III restriction enzyme res subunit
CXR27_RS16460	COG0745	RESPONSE REGULATOR receiver
CXR27_RS16465	COG2205	protein histidine kinase activity
CXR27_RS16495	COG0501	Belongs to the peptidase M48B family
CXR27_RS16505	COG2501	S4 domain
CXR27_RS16530	COG0459	protein refolding
CXR27_RS16535	COG1278	Cold shock
CXR27_RS16555	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CXR27_RS16565	COG1228	amidohydrolase
CXR27_RS16610	COG0745	RESPONSE REGULATOR receiver
CXR27_RS16615	COG5002	protein histidine kinase activity
CXR27_RS16615	COG3850	Histidine kinase
CXR27_RS16655	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CXR27_RS16660	COG0561	phosphatase activity
CXR27_RS16660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CXR27_RS16665	COG1609	Transcriptional regulator
CXR27_RS16675	COG3842	ATPase activity
CXR27_RS16685	COG1028	Short-chain dehydrogenase reductase Sdr
CXR27_RS16690	COG0531	amino acid
CXR27_RS16700	COG0215	cysteine-tRNA ligase activity
CXR27_RS16710	COG0733	neurotransmitter:sodium symporter activity
CXR27_RS16725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CXR27_RS16730	COG1113	amino acid transport
CXR27_RS16740	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CXR27_RS16745	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CXR27_RS16760	COG0745	RESPONSE REGULATOR receiver
CXR27_RS16765	COG5002	protein histidine kinase activity
CXR27_RS16775	COG0697	spore germination
CXR27_RS16785	COG0588	phosphoglycerate mutase activity
CXR27_RS16790	COG0385	Bile acid
CXR27_RS16810	COG0438	transferase activity, transferring glycosyl groups
CXR27_RS16855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CXR27_RS16870	COG0589	response to stress
CXR27_RS16875	COG0531	amino acid
CXR27_RS16880	COG0519	Catalyzes the synthesis of GMP from XMP
CXR27_RS16880	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CXR27_RS16905	COG1619	proteins homologs of microcin C7 resistance protein MccF
CXR27_RS16910	COG4172	Belongs to the ABC transporter superfamily
CXR27_RS16915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXR27_RS16920	COG0601	transmembrane transport
CXR27_RS16935	COG2358	TRAP transporter, solute receptor (TAXI family
CXR27_RS16945	COG3835	regulator
CXR27_RS16960	COG3485	protocatechuate 3,4-dioxygenase
CXR27_RS16975	COG0745	RESPONSE REGULATOR receiver
CXR27_RS16980	COG0454	-acetyltransferase
CXR27_RS16980	COG0456	acetyltransferase
CXR27_RS16985	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CXR27_RS17010	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CXR27_RS17025	COG1695	Transcriptional regulator
CXR27_RS17030	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CXR27_RS17070	COG0667	Aldo Keto reductase
CXR27_RS17085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CXR27_RS17100	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CXR27_RS17105	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CXR27_RS17110	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CXR27_RS17115	COG2188	Transcriptional regulator
CXR27_RS17120	COG0667	Aldo Keto reductase
CXR27_RS17130	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CXR27_RS17135	COG1132	(ABC) transporter
CXR27_RS17140	COG0438	transferase activity, transferring glycosyl groups
CXR27_RS17145	COG0438	transferase activity, transferring glycosyl groups
CXR27_RS17160	COG2205	protein histidine kinase activity
CXR27_RS17175	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CXR27_RS17180	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CXR27_RS17185	COG1414	Transcriptional regulator
CXR27_RS17190	COG0477	Major facilitator Superfamily
CXR27_RS17195	COG1082	Xylose isomerase domain protein TIM barrel
CXR27_RS17195	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CXR27_RS17230	COG2197	response regulator
CXR27_RS17235	COG4585	Histidine kinase
CXR27_RS17240	COG2409	Drug exporters of the RND superfamily
CXR27_RS17245	COG1335	isochorismatase
CXR27_RS17250	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CXR27_RS17265	COG0531	amino acid
CXR27_RS17270	COG0137	argininosuccinate synthase activity
CXR27_RS17295	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CXR27_RS17325	COG0765	amino acid transport
CXR27_RS17330	COG1126	abc transporter atp-binding protein
CXR27_RS17335	COG1028	Short-chain dehydrogenase reductase Sdr
CXR27_RS17340	COG1028	Short-chain dehydrogenase reductase Sdr
CXR27_RS17345	COG3938	Belongs to the proline racemase family
CXR27_RS17350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXR27_RS17355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXR27_RS17375	COG1316	TRANSCRIPTIONal
CXR27_RS17390	COG2409	Drug exporters of the RND superfamily
CXR27_RS17395	COG1309	transcriptional regulator
CXR27_RS17415	COG0531	amino acid
CXR27_RS17435	COG0604	alcohol dehydrogenase
CXR27_RS17450	COG0561	phosphatase activity
CXR27_RS17455	COG0561	phosphatase activity
CXR27_RS17460	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CXR27_RS17465	COG1597	lipid kinase activity
CXR27_RS17485	COG0789	Transcriptional regulator
CXR27_RS17490	COG0484	heat shock protein binding
CXR27_RS17495	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CXR27_RS17500	COG0443	Heat shock 70 kDa protein
CXR27_RS17520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CXR27_RS17530	COG1620	l-lactate permease
CXR27_RS17535	COG2186	Transcriptional regulator
CXR27_RS17545	COG0803	Belongs to the bacterial solute-binding protein 9 family
CXR27_RS17555	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CXR27_RS17560	COG1121	(ABC) transporter
CXR27_RS17565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CXR27_RS17570	COG0523	cobalamin synthesis protein
CXR27_RS17605	COG0145	ligase activity
CXR27_RS17610	COG4647	ligase activity
CXR27_RS17615	COG0145	ligase activity
CXR27_RS17635	COG0154	amidase activity
CXR27_RS17655	COG0514	ATP-dependent DNA helicase (RecQ)
CXR27_RS17670	COG0583	DNA-binding transcription factor activity
CXR27_RS17680	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CXR27_RS17685	COG1511	domain protein
CXR27_RS17690	COG1116	anion transmembrane transporter activity
CXR27_RS17705	COG2814	Major facilitator Superfamily
CXR27_RS17725	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CXR27_RS17725	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CXR27_RS17730	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CXR27_RS17740	COG0028	Belongs to the TPP enzyme family
CXR27_RS17750	COG0500	methyltransferase
CXR27_RS17785	COG2315	Protein conserved in bacteria
CXR27_RS17790	COG0252	asparaginase activity
CXR27_RS17795	COG2130	NADP-dependent
CXR27_RS17825	COG2197	response regulator
CXR27_RS17830	COG4585	Histidine kinase
CXR27_RS17855	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CXR27_RS17905	COG2197	response regulator
CXR27_RS17915	COG4585	Histidine kinase
CXR27_RS17925	COG4585	Histidine kinase
CXR27_RS17930	COG2197	response regulator
CXR27_RS17940	COG0431	NADPH-dependent FMN reductase
CXR27_RS17955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXR27_RS17960	COG0601	transmembrane transport
CXR27_RS17970	COG1115	amino acid carrier protein
CXR27_RS17975	COG0191	fructose-bisphosphate aldolase activity
CXR27_RS18000	COG1309	transcriptional regulator
CXR27_RS18005	COG1131	(ABC) transporter
CXR27_RS18010	COG3559	Exporter of polyketide antibiotics
CXR27_RS18025	COG1960	acyl-CoA dehydrogenase activity
CXR27_RS18030	COG1960	acyl-CoA dehydrogenase activity
CXR27_RS18045	COG4152	abc transporter atp-binding protein
CXR27_RS18050	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CXR27_RS18070	COG1595	DNA-templated transcription, initiation
CXR27_RS18075	COG1302	Protein conserved in bacteria
CXR27_RS18080	COG0300	oxidoreductase activity
CXR27_RS18110	COG1215	transferase activity, transferring glycosyl groups
CXR27_RS18130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CXR27_RS18135	COG1024	Enoyl-CoA hydratase
CXR27_RS18145	COG0542	response to heat
CXR27_RS18165	COG2957	Belongs to the agmatine deiminase family
CXR27_RS18185	COG1024	Enoyl-CoA hydratase
CXR27_RS18190	COG2814	Major facilitator Superfamily
CXR27_RS18200	COG0069	glutamate synthase activity
CXR27_RS18215	COG1028	Short-chain dehydrogenase reductase Sdr
CXR27_RS18225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CXR27_RS18230	COG0318	PFAM AMP-dependent synthetase and ligase
CXR27_RS18235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CXR27_RS18300	COG0436	Aminotransferase
CXR27_RS18330	COG4948	Mandelate Racemase Muconate Lactonizing
CXR27_RS18375	COG0710	3-dehydroquinate dehydratase activity
CXR27_RS18380	COG2267	carboxylic ester hydrolase activity
CXR27_RS18425	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CXR27_RS18430	COG1506	peptidase
CXR27_RS18430	COG0823	Involved in the tonB-independent uptake of proteins
CXR27_RS18450	COG1320	monovalent cation:proton antiporter activity
CXR27_RS18465	COG0651	ATP synthesis coupled electron transport
CXR27_RS18470	COG1006	Multisubunit Na H antiporter MnhC subunit
CXR27_RS18475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CXR27_RS18475	COG2111	Na H antiporter
CXR27_RS18485	COG0717	Belongs to the dCTP deaminase family
CXR27_RS18510	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CXR27_RS18525	COG1028	Short-chain dehydrogenase reductase Sdr
CXR27_RS18540	COG0776	regulation of translation
CXR27_RS18545	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CXR27_RS18550	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CXR27_RS18555	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CXR27_RS18565	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXR27_RS18570	COG0022	dehydrogenase e1 component
CXR27_RS18595	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CXR27_RS18600	COG2267	carboxylic ester hydrolase activity
CXR27_RS18620	COG1012	belongs to the aldehyde dehydrogenase family
CXR27_RS18635	COG0183	Belongs to the thiolase family
CXR27_RS18640	COG3290	protein histidine kinase activity
CXR27_RS18645	COG1017	nitric oxide dioxygenase activity
CXR27_RS18645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CXR27_RS18650	COG1937	Protein conserved in bacteria
CXR27_RS18665	COG0318	PFAM AMP-dependent synthetase and ligase
CXR27_RS18680	COG0745	RESPONSE REGULATOR receiver
CXR27_RS18685	COG2205	protein histidine kinase activity
CXR27_RS18700	COG3387	PFAM Glycoside hydrolase 15-related
CXR27_RS18730	COG1484	DNA-dependent DNA replication
CXR27_RS18830	COG0514	ATP-dependent DNA helicase (RecQ)
CXR27_RS18850	COG1522	sequence-specific DNA binding
CXR27_RS18860	COG2814	Major facilitator Superfamily
CXR27_RS18875	COG2326	polyphosphate kinase activity
CXR27_RS18880	COG2860	membrane
CXR27_RS18910	COG4585	Histidine kinase
CXR27_RS18915	COG2197	response regulator
CXR27_RS18965	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CXR27_RS18970	COG0477	Major facilitator Superfamily
CXR27_RS19000	COG4152	abc transporter atp-binding protein
CXR27_RS19010	COG2197	response regulator
CXR27_RS19015	COG4585	Histidine kinase
CXR27_RS19025	COG1131	(ABC) transporter
CXR27_RS19100	COG0730	response to heat
CXR27_RS19105	COG1959	2 iron, 2 sulfur cluster binding
CXR27_RS19110	COG0583	DNA-binding transcription factor activity
CXR27_RS19115	COG1982	Orn Lys Arg decarboxylase major
CXR27_RS19125	COG0477	Major facilitator Superfamily
CXR27_RS19135	COG1902	pentaerythritol trinitrate reductase activity
CXR27_RS19135	COG0446	pyridine nucleotide-disulphide oxidoreductase
CXR27_RS19145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXR27_RS19155	COG4608	Belongs to the ABC transporter superfamily
CXR27_RS19175	COG2871	sodium ion transport
CXR27_RS19180	COG4638	Rieske (2fe-2S)
CXR27_RS19185	COG0583	DNA-binding transcription factor activity
CXR27_RS19215	COG3048	D-serine ammonia-lyase activity
CXR27_RS19245	COG0277	FAD linked oxidase domain protein
CXR27_RS19260	COG0659	secondary active sulfate transmembrane transporter activity
CXR27_RS19265	COG0789	Transcriptional regulator
CXR27_RS19275	COG0477	Major facilitator Superfamily
CXR27_RS19285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CXR27_RS19315	COG1921	L-seryl-tRNASec selenium transferase activity
CXR27_RS19325	COG2801	Transposase and inactivated derivatives
CXR27_RS19335	COG4106	trans-aconitate 2-methyltransferase activity
CXR27_RS19345	COG0709	Synthesizes selenophosphate from selenide and ATP
CXR27_RS19360	COG0437	4 iron, 4 sulfur cluster binding
CXR27_RS19365	COG0243	molybdopterin cofactor binding
CXR27_RS19365	COG3383	formate dehydrogenase (NAD+) activity
CXR27_RS19370	COG3383	formate dehydrogenase (NAD+) activity
CXR27_RS19370	COG0243	molybdopterin cofactor binding
CXR27_RS19375	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CXR27_RS19380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CXR27_RS19390	COG1278	Cold shock
CXR27_RS19405	COG3226	Transcriptional regulator
CXR27_RS19420	COG0110	maltose O-acetyltransferase activity
CXR27_RS19440	COG0583	DNA-binding transcription factor activity
CXR27_RS19450	COG0305	Participates in initiation and elongation during chromosome replication
CXR27_RS19465	COG1136	(ABC) transporter
CXR27_RS19470	COG0346	lactoylglutathione lyase activity
CXR27_RS19475	COG2733	membrane
CXR27_RS19495	COG0477	Major facilitator Superfamily
CXR27_RS19505	COG0359	binds to the 23S rRNA
CXR27_RS19510	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CXR27_RS19520	COG0360	Binds together with S18 to 16S ribosomal RNA
CXR27_RS19535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CXR27_RS19540	COG0617	tRNA 3'-terminal CCA addition
CXR27_RS19565	COG0492	ferredoxin-NADP+ reductase activity
CXR27_RS19570	COG3118	belongs to the thioredoxin family
CXR27_RS19575	COG3409	Peptidoglycan-binding domain 1 protein
CXR27_RS19575	COG0860	N-Acetylmuramoyl-L-alanine amidase
CXR27_RS19585	COG1192	Involved in chromosome partitioning
CXR27_RS19590	COG0357	Ribosomal RNA small subunit methyltransferase G
CXR27_RS19605	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CXR27_RS19610	COG0594	ribonuclease P activity
CXR27_RS19615	COG0230	Belongs to the bacterial ribosomal protein bL34 family