locus-tag	class	description
C628_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C628_RS00010	COG0592	DNA-directed DNA polymerase activity
C628_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C628_RS00025	COG0187	DNA topoisomerase II activity
C628_RS00085	COG2855	membrane
C628_RS00090	COG0583	DNA-binding transcription factor activity
C628_RS00105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C628_RS00105	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C628_RS00120	COG0656	L-ascorbic acid biosynthetic process
C628_RS00150	COG0604	alcohol dehydrogenase
C628_RS00150	COG1028	Short-chain dehydrogenase reductase Sdr
C628_RS00150	COG3321	synthase
C628_RS00190	COG0297	glycogen (starch) synthase activity
C628_RS00195	COG0438	transferase activity, transferring glycosyl groups
C628_RS00200	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C628_RS00205	COG0438	transferase activity, transferring glycosyl groups
C628_RS00225	COG1764	response to oxidative stress
C628_RS00240	COG0803	Belongs to the bacterial solute-binding protein 9 family
C628_RS00245	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C628_RS00250	COG1121	(ABC) transporter
C628_RS00260	COG1172	Belongs to the binding-protein-dependent transport system permease family
C628_RS00265	COG1129	ABC transporter
C628_RS00285	COG2207	Transcriptional regulator
C628_RS00290	COG4592	Periplasmic binding protein
C628_RS00295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C628_RS00300	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C628_RS00305	COG1120	ATPase activity
C628_RS00325	COG0515	serine threonine protein kinase
C628_RS00325	COG2815	serine threonine protein kinase
C628_RS00330	COG0515	serine threonine protein kinase
C628_RS00335	COG0768	penicillin binding
C628_RS00355	COG1716	ATPase activity
C628_RS00365	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C628_RS00415	COG0730	response to heat
C628_RS00420	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C628_RS00425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C628_RS00430	COG1937	Protein conserved in bacteria
C628_RS00435	COG2826	transposase and inactivated derivatives, IS30 family
C628_RS00485	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C628_RS00495	COG2851	Citrate transporter
C628_RS00500	COG3290	protein histidine kinase activity
C628_RS00505	COG4565	transcriptional regulatory protein
C628_RS00510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C628_RS00520	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C628_RS00560	COG0402	S-adenosylhomocysteine deaminase activity
C628_RS00575	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C628_RS00610	COG0804	urea catabolic process
C628_RS00615	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C628_RS00620	COG0830	nickel cation binding
C628_RS00625	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C628_RS00630	COG0829	nickel cation binding
C628_RS00635	COG2814	Major facilitator Superfamily
C628_RS00645	COG0326	Molecular chaperone. Has ATPase activity
C628_RS00650	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C628_RS00670	COG1012	belongs to the aldehyde dehydrogenase family
C628_RS00675	COG0667	Aldo Keto reductase
C628_RS00680	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C628_RS00690	COG2149	membrane
C628_RS00710	COG0346	lactoylglutathione lyase activity
C628_RS00725	COG2814	Major facilitator Superfamily
C628_RS00735	COG1070	Carbohydrate kinase
C628_RS00770	COG3311	Transcriptional regulator
C628_RS00785	COG0657	acetylesterase activity
C628_RS00795	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C628_RS00830	COG2860	membrane
C628_RS00850	COG3180	Ammonia monooxygenase
C628_RS00860	COG0730	response to heat
C628_RS00870	COG1643	Atp-dependent helicase
C628_RS00875	COG0110	maltose O-acetyltransferase activity
C628_RS00885	COG2818	Glycosylase
C628_RS00890	COG1280	lysine exporter protein (LysE YggA)
C628_RS00920	COG0251	oxidation-reduction process
C628_RS00935	COG3590	peptidase
C628_RS00950	COG2188	Transcriptional regulator
C628_RS00955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C628_RS00970	COG3718	enzyme involved in inositol metabolism
C628_RS00975	COG3962	Belongs to the TPP enzyme family
C628_RS00990	COG1082	Xylose isomerase domain protein TIM barrel
C628_RS01000	COG0673	inositol 2-dehydrogenase activity
C628_RS01020	COG0673	inositol 2-dehydrogenase activity
C628_RS01030	COG1278	Cold shock
C628_RS01050	COG3842	ATPase activity
C628_RS01060	COG1609	Transcriptional regulator
C628_RS01085	COG2814	Major facilitator Superfamily
C628_RS01095	COG0069	glutamate synthase activity
C628_RS01095	COG0067	glutamate synthase
C628_RS01095	COG0070	glutamate synthase
C628_RS01110	COG2197	response regulator
C628_RS01120	COG2801	Transposase and inactivated derivatives
C628_RS01145	COG1028	Short-chain dehydrogenase reductase Sdr
C628_RS01150	COG1396	sequence-specific DNA binding
C628_RS01165	COG1028	Short-chain dehydrogenase reductase Sdr
C628_RS01170	COG0277	FAD linked oxidase domain protein
C628_RS01210	COG1216	Glycosyl transferase, family 2
C628_RS01255	COG1115	amino acid carrier protein
C628_RS01280	COG0315	cyclic pyranopterin monophosphate synthase activity
C628_RS01280	COG0521	Mo-molybdopterin cofactor biosynthetic process
C628_RS01300	COG0725	ABC transporter, periplasmic molybdate-binding protein
C628_RS01310	COG3842	ATPase activity
C628_RS01315	COG1950	PFAM Membrane protein of
C628_RS01320	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C628_RS01335	COG2239	Acts as a magnesium transporter
C628_RS01340	COG0471	metal ion transport
C628_RS01350	COG0287	Prephenate dehydrogenase
C628_RS01365	COG3237	CsbD-like
C628_RS01380	COG2409	Drug exporters of the RND superfamily
C628_RS01385	COG0343	queuine tRNA-ribosyltransferase activity
C628_RS01405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C628_RS01430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C628_RS01455	COG3442	glutamine amidotransferase
C628_RS01460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C628_RS01495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C628_RS01500	COG0697	spore germination
C628_RS01505	COG0527	aspartate kinase activity
C628_RS01540	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C628_RS01560	COG0798	PFAM Bile acid sodium symporter
C628_RS01565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C628_RS01585	COG0651	ATP synthesis coupled electron transport
C628_RS01590	COG1006	Multisubunit Na H antiporter MnhC subunit
C628_RS01595	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C628_RS01595	COG2111	Na H antiporter
C628_RS01610	COG0745	RESPONSE REGULATOR receiver
C628_RS01625	COG2801	Transposase and inactivated derivatives
C628_RS01660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C628_RS01675	COG0251	oxidation-reduction process
C628_RS01680	COG0477	Major facilitator Superfamily
C628_RS01690	COG1846	Transcriptional regulator
C628_RS01695	COG1028	Short-chain dehydrogenase reductase Sdr
C628_RS01705	COG1960	acyl-CoA dehydrogenase activity
C628_RS01715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C628_RS01720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C628_RS01735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C628_RS01805	COG1111	helicase
C628_RS01805	COG1205	dead DEAH box helicase
C628_RS01810	COG1278	Cold shock
C628_RS01815	COG1754	DNA topoisomerase type I activity
C628_RS01815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C628_RS01855	COG0564	pseudouridine synthase activity
C628_RS01875	COG1028	Short-chain dehydrogenase reductase Sdr
C628_RS01880	COG2814	Major facilitator Superfamily
C628_RS01890	COG2826	transposase and inactivated derivatives, IS30 family
C628_RS01915	COG0737	Belongs to the 5'-nucleotidase family
C628_RS01920	COG1064	alcohol dehydrogenase
C628_RS01945	COG1088	dTDP-glucose 4,6-dehydratase activity
C628_RS01950	COG0778	Nitroreductase
C628_RS01955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C628_RS01975	COG1505	serine-type exopeptidase activity
C628_RS02035	COG1088	dTDP-glucose 4,6-dehydratase activity
C628_RS02045	COG0443	Heat shock 70 kDa protein
C628_RS02100	COG1505	serine-type exopeptidase activity
C628_RS02115	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C628_RS02140	COG3328	transposase activity
C628_RS02145	COG2801	Transposase and inactivated derivatives
C628_RS02200	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C628_RS02205	COG2801	Transposase and inactivated derivatives
C628_RS02215	COG2963	transposase activity
C628_RS02265	COG3547	Transposase (IS116 IS110 IS902 family)
C628_RS02275	COG2801	Transposase and inactivated derivatives
C628_RS02280	COG2801	Transposase and inactivated derivatives
C628_RS02285	COG2963	transposase activity
C628_RS02300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C628_RS02305	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C628_RS02310	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C628_RS02315	COG3800	Transcriptional regulator
C628_RS02315	COG1396	sequence-specific DNA binding
C628_RS02325	COG1053	succinate dehydrogenase
C628_RS02330	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C628_RS02350	COG2733	membrane
C628_RS02380	COG0788	formyltetrahydrofolate deformylase activity
C628_RS02385	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C628_RS02395	COG1937	Protein conserved in bacteria
C628_RS02415	COG4558	Periplasmic binding protein
C628_RS02420	COG4139	cobalamin transport
C628_RS02425	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C628_RS02455	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C628_RS02465	COG0318	PFAM AMP-dependent synthetase and ligase
C628_RS02480	COG5002	protein histidine kinase activity
C628_RS02485	COG0745	RESPONSE REGULATOR receiver
C628_RS02495	COG0577	efflux transmembrane transporter activity
C628_RS02515	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C628_RS02535	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C628_RS02540	COG0181	hydroxymethylbilane synthase activity
C628_RS02555	COG0477	Major facilitator Superfamily
C628_RS02560	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C628_RS02560	COG1082	Xylose isomerase domain protein TIM barrel
C628_RS02565	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C628_RS02575	COG0222	ribosome binding
C628_RS02590	COG3842	ATPase activity
C628_RS02605	COG1648	precorrin-2 dehydrogenase activity
C628_RS02605	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C628_RS02615	COG0113	porphobilinogen synthase activity
C628_RS02630	COG2217	Heavy metal translocating P-type atpase
C628_RS02635	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C628_RS02645	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C628_RS02650	COG0406	alpha-ribazole phosphatase activity
C628_RS02660	COG0785	Cytochrome C biogenesis protein
C628_RS02670	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C628_RS02725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C628_RS02730	COG0583	DNA-binding transcription factor activity
C628_RS02795	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C628_RS02800	COG2154	pterin-4-alpha-carbinolamine dehydratase
C628_RS02805	COG3340	Belongs to the peptidase S51 family
C628_RS02810	COG4948	Mandelate Racemase Muconate Lactonizing
C628_RS02825	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C628_RS02825	COG0438	transferase activity, transferring glycosyl groups
C628_RS02830	COG1113	amino acid transport
C628_RS02845	COG0142	geranyltranstransferase activity
C628_RS02875	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C628_RS02885	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C628_RS02950	COG0085	RNA polymerase activity
C628_RS02975	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C628_RS02985	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C628_RS03015	COG1120	ATPase activity
C628_RS03025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C628_RS03035	COG0427	acetyl-CoA hydrolase
C628_RS03055	COG2409	Drug exporters of the RND superfamily
C628_RS03060	COG3415	Transposase
C628_RS03060	COG2801	Transposase and inactivated derivatives
C628_RS03075	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C628_RS03165	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C628_RS03190	COG3845	ABC transporter
C628_RS03225	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C628_RS03235	COG1841	ribosomal large subunit assembly
C628_RS03280	COG0574	Belongs to the PEP-utilizing enzyme family
C628_RS03280	COG3848	Pyruvate phosphate dikinase
C628_RS03295	COG1414	Transcriptional regulator
C628_RS03300	COG0201	protein transport
C628_RS03345	COG0203	ribosomal protein L17
C628_RS03350	COG0101	tRNA pseudouridine synthase activity
C628_RS03375	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C628_RS03385	COG1404	Belongs to the peptidase S8 family
C628_RS03395	COG1674	ftsk spoiiie
C628_RS03460	COG2985	domain, Protein
C628_RS03460	COG0569	domain protein
C628_RS03485	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C628_RS03485	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C628_RS03500	COG0459	protein refolding
C628_RS03530	COG0516	GMP reductase activity
C628_RS03540	COG0583	DNA-binding transcription factor activity
C628_RS03545	COG0519	Catalyzes the synthesis of GMP from XMP
C628_RS03545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C628_RS03565	COG2197	response regulator
C628_RS03590	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C628_RS03630	COG2409	Drug exporters of the RND superfamily
C628_RS03645	COG2801	Transposase and inactivated derivatives
C628_RS03660	COG0702	epimerase
C628_RS03665	COG0415	Belongs to the DNA photolyase family
C628_RS03675	COG2801	Transposase and inactivated derivatives
C628_RS03695	COG0577	efflux transmembrane transporter activity
C628_RS03695	COG1136	(ABC) transporter
C628_RS03700	COG2011	ABC-type metal ion transport system permease component
C628_RS03705	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C628_RS03710	COG1464	Belongs to the NlpA lipoprotein family
C628_RS03715	COG0587	DNA-directed DNA polymerase activity
C628_RS03740	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C628_RS03755	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C628_RS03785	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C628_RS03790	COG2873	o-acetylhomoserine
C628_RS03795	COG1966	Carbon starvation protein
C628_RS03805	COG2079	MmgE PrpD family protein
C628_RS03810	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C628_RS03815	COG0372	Belongs to the citrate synthase family
C628_RS03825	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C628_RS03840	COG2838	Isocitrate dehydrogenase
C628_RS03850	COG1120	ATPase activity
C628_RS03855	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C628_RS03860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C628_RS03870	COG2814	Major facilitator Superfamily
C628_RS03880	COG2860	membrane
C628_RS03895	COG1120	ATPase activity
C628_RS03900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C628_RS03905	COG0180	Tryptophanyl-tRNA synthetase
C628_RS03910	COG1295	ribonuclease BN
C628_RS03920	COG1686	Belongs to the peptidase S11 family
C628_RS03930	COG0791	NLP P60 protein
C628_RS03930	COG0741	lytic transglycosylase activity
C628_RS03950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C628_RS03955	COG1473	amidohydrolase
C628_RS03955	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C628_RS03965	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C628_RS03980	COG0523	cobalamin synthesis protein
C628_RS03985	COG0492	ferredoxin-NADP+ reductase activity
C628_RS03990	COG2079	MmgE PrpD family protein
C628_RS03995	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C628_RS04000	COG0372	Belongs to the citrate synthase family
C628_RS04010	COG1396	sequence-specific DNA binding
C628_RS04010	COG3800	Transcriptional regulator
C628_RS04020	COG4770	biotin carboxylase activity
C628_RS04025	COG2897	thiosulfate sulfurtransferase activity
C628_RS04030	COG0189	ligase activity
C628_RS04055	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C628_RS04060	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C628_RS04105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C628_RS04155	COG3842	ATPase activity
C628_RS04160	COG2801	Transposase and inactivated derivatives
C628_RS04190	COG0210	DNA helicase
C628_RS04195	COG1201	RNA secondary structure unwinding
C628_RS04205	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C628_RS04210	COG1316	TRANSCRIPTIONal
C628_RS04250	COG1482	cell wall glycoprotein biosynthetic process
C628_RS04275	COG0745	RESPONSE REGULATOR receiver
C628_RS04280	COG5002	protein histidine kinase activity
C628_RS04295	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C628_RS04310	COG1011	Hydrolase
C628_RS04320	COG1162	GTPase activity
C628_RS04325	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C628_RS04360	COG0513	Belongs to the DEAD box helicase family
C628_RS04385	COG0210	DNA helicase
C628_RS04390	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C628_RS04395	COG2816	NAD+ diphosphatase activity
C628_RS04420	COG3480	Lon protease (S16) C-terminal proteolytic domain
C628_RS04435	COG1615	UPF0182 protein
C628_RS04445	COG1615	UPF0182 protein
C628_RS04450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C628_RS04455	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C628_RS04460	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C628_RS04535	COG0483	inositol monophosphate 1-phosphatase activity
C628_RS04540	COG0483	inositol monophosphate 1-phosphatase activity
C628_RS04550	COG2884	Cell division ATP-binding protein ftsE
C628_RS04555	COG2177	Part of the ABC transporter FtsEX involved in
C628_RS04565	COG3189	MarR family transcriptional regulator
C628_RS04580	COG1132	(ABC) transporter
C628_RS04580	COG2375	cellular response to nickel ion
C628_RS04585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C628_RS04645	COG1061	Type III restriction enzyme res subunit
C628_RS04660	COG1652	LysM domain
C628_RS04685	COG2252	PERMEase
C628_RS04690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C628_RS04710	COG0372	Belongs to the citrate synthase family
C628_RS04715	COG0545	Peptidyl-prolyl cis-trans isomerase
C628_RS04730	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C628_RS04740	COG3757	hydrolase, family 25
C628_RS04745	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C628_RS04760	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C628_RS04780	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C628_RS04795	COG1218	3'(2'),5'-bisphosphate nucleotidase
C628_RS04800	COG1201	RNA secondary structure unwinding
C628_RS04805	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C628_RS04810	COG3304	Inner membrane component domain
C628_RS04815	COG0586	Pfam SNARE associated Golgi protein
C628_RS04825	COG0166	Belongs to the GPI family
C628_RS04845	COG1605	Chorismate mutase
C628_RS04870	COG0739	heme binding
C628_RS04890	COG0138	bifunctional purine biosynthesis protein purh
C628_RS04900	COG1309	transcriptional regulator
C628_RS04930	COG0659	secondary active sulfate transmembrane transporter activity
C628_RS04950	COG0745	RESPONSE REGULATOR receiver
C628_RS04960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C628_RS04980	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C628_RS04985	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C628_RS05005	COG2807	transmembrane transport
C628_RS05025	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
C628_RS05035	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C628_RS05050	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C628_RS05060	COG0657	acetylesterase activity
C628_RS05070	COG2801	Transposase and inactivated derivatives
C628_RS05080	COG0277	FAD linked oxidase domain protein
C628_RS05095	COG2801	Transposase and inactivated derivatives
C628_RS05110	COG0084	hydrolase, TatD family'
C628_RS05115	COG3583	domain protein
C628_RS05130	COG0488	(ABC) transporter
C628_RS05155	COG2326	polyphosphate kinase activity
C628_RS05160	COG0561	phosphatase activity
C628_RS05190	COG2409	Drug exporters of the RND superfamily
C628_RS05195	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C628_RS05235	COG0411	ABC transporter
C628_RS05245	COG0193	aminoacyl-tRNA hydrolase activity
C628_RS05260	COG0193	aminoacyl-tRNA hydrolase activity
C628_RS05265	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C628_RS05290	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C628_RS05295	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C628_RS05305	COG2132	Multicopper oxidase
C628_RS05310	COG1131	(ABC) transporter
C628_RS05320	COG4585	Histidine kinase
C628_RS05325	COG2909	trisaccharide binding
C628_RS05335	COG1132	(ABC) transporter
C628_RS05340	COG1132	(ABC) transporter
C628_RS05345	COG0405	Gamma-glutamyltransferase
C628_RS05380	COG1309	transcriptional regulator
C628_RS05400	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C628_RS05405	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C628_RS05410	COG0531	amino acid
C628_RS05415	COG2963	transposase activity
C628_RS05420	COG2801	Transposase and inactivated derivatives
C628_RS05425	COG0531	amino acid
C628_RS05435	COG3956	TIGRFAM MazG family protein
C628_RS05485	COG2207	Transcriptional regulator
C628_RS05500	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C628_RS05510	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C628_RS05520	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C628_RS05525	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C628_RS05585	COG1914	H( )-stimulated, divalent metal cation uptake system
C628_RS05590	COG2188	Transcriptional regulator
C628_RS05600	COG0114	fumarate hydratase activity
C628_RS05640	COG1494	fructose-1,6-bisphosphatase
C628_RS05655	COG2814	Major facilitator Superfamily
C628_RS05665	COG1570	exodeoxyribonuclease VII activity
C628_RS05680	COG0628	permease
C628_RS05690	COG0733	neurotransmitter:sodium symporter activity
C628_RS05700	COG0012	GTP binding
C628_RS05715	COG3609	addiction module antidote protein, CC2985 family
C628_RS05720	COG1733	regulation of RNA biosynthetic process
C628_RS05735	COG0494	nUDIX hydrolase
C628_RS05750	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C628_RS05760	COG2801	Transposase and inactivated derivatives
C628_RS05785	COG2814	Major facilitator Superfamily
C628_RS05805	COG0702	epimerase
C628_RS05850	COG0488	(ABC) transporter
C628_RS05860	COG2824	Alkylphosphonate utilization operon protein PhnA
C628_RS05870	COG2814	Major facilitator Superfamily
C628_RS05875	COG1104	cysteine desulfurase activity
C628_RS05885	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C628_RS05900	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C628_RS05905	COG2315	Protein conserved in bacteria
C628_RS05910	COG0095	Lipoate-protein ligase
C628_RS05920	COG2814	Major facilitator Superfamily
C628_RS05930	COG4721	ABC-type cobalt transport system, permease component
C628_RS05935	COG1122	ATPase activity
C628_RS05955	COG0387	Pfam Sodium calcium exchanger
C628_RS05970	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C628_RS05975	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C628_RS05985	COG2354	Protein conserved in bacteria
C628_RS05990	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C628_RS06000	COG0494	nUDIX hydrolase
C628_RS06020	COG3949	Membrane
C628_RS06035	COG1217	gtp-binding protein TYPA
C628_RS06040	COG0747	negative chemotaxis
C628_RS06075	COG2171	N-acyltransferase activity
C628_RS06080	COG1113	amino acid transport
C628_RS06090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C628_RS06100	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C628_RS06105	COG0463	Glycosyl transferase, family 2
C628_RS06130	COG0297	glycogen (starch) synthase activity
C628_RS06140	COG4122	O-methyltransferase activity
C628_RS06145	COG1595	DNA-templated transcription, initiation
C628_RS06190	COG0508	dehydrogenase complex catalyzes the overall conversion of
C628_RS06190	COG0567	Dehydrogenase, E1 component
C628_RS06195	COG1132	(ABC) transporter
C628_RS06205	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C628_RS06210	COG2272	Belongs to the type-B carboxylesterase lipase family
C628_RS06230	COG2814	Major facilitator Superfamily
C628_RS06275	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C628_RS06280	COG4988	ABC transporter
C628_RS06285	COG1294	oxidase, subunit
C628_RS06290	COG1271	oxidase subunit
C628_RS06305	COG2963	transposase activity
C628_RS06345	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C628_RS06350	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C628_RS06375	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C628_RS06390	COG2353	YceI-like domain
C628_RS06395	COG1846	Transcriptional regulator
C628_RS06410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C628_RS06415	COG2217	Heavy metal translocating P-type atpase
C628_RS06425	COG2357	RelA SpoT domain protein
C628_RS06450	COG0019	diaminopimelate decarboxylase activity
C628_RS06465	COG0460	homoserine dehydrogenase
C628_RS06490	COG1140	nitrate reductase beta subunit
C628_RS06505	COG2826	transposase and inactivated derivatives, IS30 family
C628_RS06510	COG0521	Mo-molybdopterin cofactor biosynthetic process
C628_RS06510	COG0315	cyclic pyranopterin monophosphate synthase activity
C628_RS06530	COG1253	flavin adenine dinucleotide binding
C628_RS06540	COG0746	molybdenum cofactor guanylyltransferase activity
C628_RS06550	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C628_RS06595	COG0356	it plays a direct role in the translocation of protons across the membrane
C628_RS06600	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C628_RS06605	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C628_RS06615	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C628_RS06620	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C628_RS06630	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C628_RS06650	COG0346	lactoylglutathione lyase activity
C628_RS06665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C628_RS06670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C628_RS06675	COG1116	anion transmembrane transporter activity
C628_RS06680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C628_RS06685	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C628_RS06690	COG0366	Alpha amylase catalytic
C628_RS06695	COG1119	ATPase activity
C628_RS06720	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C628_RS06725	COG1104	cysteine desulfurase activity
C628_RS06740	COG1396	sequence-specific DNA binding
C628_RS06815	COG0205	6-phosphofructokinase activity
C628_RS06820	COG1609	Transcriptional regulator
C628_RS06825	COG1129	ABC transporter
C628_RS06830	COG1869	D-ribose catabolic process
C628_RS06845	COG0385	Bile acid
C628_RS06860	COG0667	Aldo Keto reductase
C628_RS06865	COG1279	arginine transmembrane transporter activity
C628_RS06870	COG0583	DNA-binding transcription factor activity
C628_RS06875	COG0435	Glutathione S-transferase
C628_RS06890	COG0129	dihydroxy-acid dehydratase activity
C628_RS06900	COG0668	transmembrane transport
C628_RS06905	COG0028	Belongs to the TPP enzyme family
C628_RS06910	COG0440	acetolactate synthase activity
C628_RS06920	COG1116	anion transmembrane transporter activity
C628_RS06925	COG1116	anion transmembrane transporter activity
C628_RS06955	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C628_RS06995	COG0473	3-isopropylmalate dehydrogenase activity
C628_RS07015	COG0179	Fumarylacetoacetate (FAA) hydrolase
C628_RS07035	COG3655	Transcriptional regulator
C628_RS07105	COG2189	Belongs to the N(4) N(6)-methyltransferase family
C628_RS07145	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C628_RS07155	COG0419	ATPase involved in DNA repair
C628_RS07160	COG1074	ATP-dependent DNA helicase activity
C628_RS07185	COG3586	endonuclease activity
C628_RS07195	COG4969	Belongs to the N-Me-Phe pilin family
C628_RS07220	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C628_RS07245	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C628_RS07260	COG0058	SHG alpha-glucan phosphorylase activity
C628_RS07270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C628_RS07285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C628_RS07300	COG0066	3-isopropylmalate dehydratase activity
C628_RS07305	COG0406	alpha-ribazole phosphatase activity
C628_RS07305	COG0494	nUDIX hydrolase
C628_RS07330	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C628_RS07335	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C628_RS07340	COG1461	Dihydroxyacetone kinase
C628_RS07345	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C628_RS07355	COG0742	ribosomal rna small subunit methyltransferase
C628_RS07365	COG1126	abc transporter atp-binding protein
C628_RS07375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C628_RS07410	COG2801	Transposase and inactivated derivatives
C628_RS07415	COG2963	transposase activity
C628_RS07460	COG2801	Transposase and inactivated derivatives
C628_RS07520	COG0656	L-ascorbic acid biosynthetic process
C628_RS07525	COG2226	methyltransferase
C628_RS07530	COG0539	negative regulation of cytoplasmic translation
C628_RS07550	COG2801	Transposase and inactivated derivatives
C628_RS07580	COG0477	Major facilitator Superfamily
C628_RS07585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C628_RS07590	COG1609	Transcriptional regulator
C628_RS07610	COG0577	efflux transmembrane transporter activity
C628_RS07610	COG1136	(ABC) transporter
C628_RS07630	COG1733	regulation of RNA biosynthetic process
C628_RS07635	COG2801	Transposase and inactivated derivatives
C628_RS07645	COG0702	epimerase
C628_RS07650	COG3973	AAA domain
C628_RS07675	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C628_RS07695	COG1175	transmembrane transport
C628_RS07710	COG2801	Transposase and inactivated derivatives
C628_RS07730	COG3842	ATPase activity
C628_RS07740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C628_RS07745	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C628_RS07750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C628_RS07750	COG0072	phenylalanine-tRNA ligase activity
C628_RS07770	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C628_RS07785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C628_RS07790	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C628_RS07800	COG0137	argininosuccinate synthase activity
C628_RS07825	COG2835	tetraacyldisaccharide 4'-kinase activity
C628_RS07830	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C628_RS07865	COG0647	UMP catabolic process
C628_RS07880	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C628_RS07905	COG0494	nUDIX hydrolase
C628_RS07910	COG4974	Belongs to the 'phage' integrase family
C628_RS07915	COG0488	(ABC) transporter
C628_RS07935	COG2897	thiosulfate sulfurtransferase activity
C628_RS07940	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C628_RS07950	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C628_RS07955	COG1160	GTP binding
C628_RS07975	COG1132	(ABC) transporter
C628_RS07980	COG1132	(ABC) transporter
C628_RS07985	COG0428	transporter
C628_RS07990	COG0025	NhaP-type Na H and K H
C628_RS08005	COG3012	SEC-C Motif Domain Protein
C628_RS08015	COG0653	protein targeting
C628_RS08020	COG1716	ATPase activity
C628_RS08055	COG1253	flavin adenine dinucleotide binding
C628_RS08060	COG1253	flavin adenine dinucleotide binding
C628_RS08065	COG0513	Belongs to the DEAD box helicase family
C628_RS08075	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C628_RS08095	COG0842	Transport permease protein
C628_RS08105	COG3639	organic phosphonate transmembrane transporter activity
C628_RS08110	COG3639	organic phosphonate transmembrane transporter activity
C628_RS08115	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C628_RS08130	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C628_RS08130	COG0351	phosphomethylpyrimidine kinase
C628_RS08130	COG0352	thiamine-phosphate diphosphorylase activity
C628_RS08135	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C628_RS08140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C628_RS08150	COG0477	Major facilitator Superfamily
C628_RS08155	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C628_RS08180	COG0659	secondary active sulfate transmembrane transporter activity
C628_RS08210	COG0463	Glycosyl transferase, family 2
C628_RS08260	COG0805	protein transport
C628_RS08265	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C628_RS08290	COG4122	O-methyltransferase activity
C628_RS08305	COG1362	aminopeptidase activity
C628_RS08320	COG2814	Major facilitator Superfamily
C628_RS08325	COG1027	Aspartate ammonia-lyase
C628_RS08340	COG0546	phosphoglycolate phosphatase activity
C628_RS08345	COG1410	methionine synthase
C628_RS08345	COG0646	methionine synthase
C628_RS08355	COG2072	flavoprotein involved in K transport
C628_RS08360	COG0798	PFAM Bile acid sodium symporter
C628_RS08365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C628_RS08370	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C628_RS08385	COG1968	undecaprenyl-diphosphatase activity
C628_RS08390	COG0667	Aldo Keto reductase
C628_RS08415	COG1881	PFAM PEBP family protein
C628_RS08420	COG1132	(ABC) transporter
C628_RS08425	COG1132	(ABC) transporter
C628_RS08495	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C628_RS08500	COG3883	PFAM NLP P60 protein
C628_RS08500	COG0791	NLP P60 protein
C628_RS08510	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C628_RS08515	COG1309	transcriptional regulator
C628_RS08535	COG3830	Belongs to the UPF0237 family
C628_RS08540	COG2848	UPF0210 protein
C628_RS08545	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C628_RS08585	COG0582	viral genome integration into host DNA
C628_RS08595	COG0488	(ABC) transporter
C628_RS08620	COG0822	iron-sulfur transferase activity
C628_RS08630	COG0396	ATPase activity
C628_RS08685	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C628_RS08690	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C628_RS08715	COG2423	ornithine cyclodeaminase activity
C628_RS08720	COG0004	ammonium transporteR
C628_RS08725	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C628_RS08730	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C628_RS08735	COG0149	triose-phosphate isomerase activity
C628_RS08740	COG0126	phosphoglycerate kinase activity
C628_RS08745	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C628_RS08755	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C628_RS08765	COG0322	excinuclease ABC activity
C628_RS08810	COG0242	peptide deformylase activity
C628_RS08820	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C628_RS08830	COG1758	RNA polymerase activity
C628_RS08835	COG0194	GDP metabolic process
C628_RS08855	COG0505	Belongs to the CarA family
C628_RS08860	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C628_RS08865	COG0540	Belongs to the ATCase OTCase family
C628_RS08870	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C628_RS08895	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C628_RS08905	COG0006	proline dipeptidase activity
C628_RS08910	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C628_RS08915	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C628_RS08920	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C628_RS08935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C628_RS08945	COG1120	ATPase activity
C628_RS08950	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C628_RS08955	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C628_RS08960	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C628_RS08990	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C628_RS09015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C628_RS09025	COG1760	l-serine dehydratase
C628_RS09030	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C628_RS09035	COG0124	histidyl-tRNA synthetase
C628_RS09045	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C628_RS09060	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C628_RS09065	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C628_RS09070	COG0747	negative chemotaxis
C628_RS09075	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C628_RS09080	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C628_RS09095	COG0632	four-way junction helicase activity
C628_RS09100	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C628_RS09105	COG0217	transcriptional regulatory protein
C628_RS09110	COG1946	Acyl-CoA thioesterase
C628_RS09125	COG0438	transferase activity, transferring glycosyl groups
C628_RS09130	COG1560	Kdo2-lipid A biosynthetic process
C628_RS09135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C628_RS09145	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C628_RS09150	COG2837	iron assimilation
C628_RS09155	COG2847	Copper chaperone PCu(A)C
C628_RS09165	COG2801	Transposase and inactivated derivatives
C628_RS09215	COG1929	Belongs to the glycerate kinase type-1 family
C628_RS09235	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C628_RS09240	COG3253	May function as heme-dependent peroxidase
C628_RS09250	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C628_RS09260	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C628_RS09270	COG0756	dUTP diphosphatase activity
C628_RS09290	COG0483	inositol monophosphate 1-phosphatase activity
C628_RS09305	COG2311	Membrane
C628_RS09315	COG1061	Type III restriction enzyme res subunit
C628_RS09345	COG1321	iron dependent repressor
C628_RS09350	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C628_RS09370	COG0583	DNA-binding transcription factor activity
C628_RS09380	COG1643	Atp-dependent helicase
C628_RS09400	COG1349	DNA-binding transcription factor activity
C628_RS09410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C628_RS09420	COG1105	Belongs to the carbohydrate kinase PfkB family
C628_RS09425	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C628_RS09425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C628_RS09425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C628_RS09440	COG2233	PERMEase
C628_RS09445	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C628_RS09460	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C628_RS09465	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C628_RS09475	COG1196	nuclear chromosome segregation
C628_RS09495	COG1126	abc transporter atp-binding protein
C628_RS09500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C628_RS09505	COG0765	amino acid transport
C628_RS09510	COG0765	amino acid transport
C628_RS09515	COG2137	regulation of response to DNA damage stimulus
C628_RS09535	COG1268	BioY protein
C628_RS09540	COG1122	ATPase activity
C628_RS09550	COG1842	Phage shock protein A
C628_RS09555	COG1396	sequence-specific DNA binding
C628_RS09585	COG1674	ftsk spoiiie
C628_RS09595	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C628_RS09600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C628_RS09605	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
C628_RS09620	COG1185	polyribonucleotide nucleotidyltransferase activity
C628_RS09640	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C628_RS09650	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C628_RS09660	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C628_RS09665	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C628_RS09670	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C628_RS09695	COG4166	transmembrane transport
C628_RS09700	COG0601	transmembrane transport
C628_RS09705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C628_RS09710	COG4172	Belongs to the ABC transporter superfamily
C628_RS09720	COG2801	Transposase and inactivated derivatives
C628_RS09730	COG0442	prolyl-tRNA aminoacylation
C628_RS09735	COG3022	response to hydroperoxide
C628_RS09795	COG2197	response regulator
C628_RS09800	COG3850	Histidine kinase
C628_RS09805	COG0577	efflux transmembrane transporter activity
C628_RS09810	COG1136	(ABC) transporter
C628_RS09810	COG0577	efflux transmembrane transporter activity
C628_RS09815	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C628_RS09820	COG0750	zinc metalloprotease
C628_RS09845	COG1131	(ABC) transporter
C628_RS09850	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C628_RS09865	COG0233	cytoplasmic translational termination
C628_RS09875	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C628_RS09890	COG4974	Belongs to the 'phage' integrase family
C628_RS09905	COG0792	nuclease activity
C628_RS09915	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C628_RS09920	COG0681	Belongs to the peptidase S26 family
C628_RS09935	COG0352	thiamine-phosphate diphosphorylase activity
C628_RS09940	COG2022	thiamine diphosphate biosynthetic process
C628_RS09940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C628_RS09955	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C628_RS09965	COG1609	Transcriptional regulator
C628_RS09970	COG0471	metal ion transport
C628_RS09975	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C628_RS09990	COG0336	Belongs to the RNA methyltransferase TrmD family
C628_RS10000	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C628_RS10035	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C628_RS10065	COG1254	Belongs to the acylphosphatase family
C628_RS10095	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C628_RS10100	COG0571	ribonuclease III activity
C628_RS10115	COG1132	(ABC) transporter
C628_RS10120	COG1132	(ABC) transporter
C628_RS10125	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C628_RS10130	COG1929	Belongs to the glycerate kinase type-1 family
C628_RS10165	COG2514	catechol 2,3-dioxygenase activity
C628_RS10170	COG0469	pyruvate kinase activity
C628_RS10180	COG0134	indole-3-glycerol-phosphate synthase activity
C628_RS10190	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C628_RS10200	COG0483	inositol monophosphate 1-phosphatase activity
C628_RS10205	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C628_RS10210	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C628_RS10235	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C628_RS10265	COG2226	methyltransferase
C628_RS10275	COG0673	inositol 2-dehydrogenase activity
C628_RS10280	COG1609	Transcriptional regulator
C628_RS10295	COG1120	ATPase activity
C628_RS10300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C628_RS10350	COG1739	Uncharacterized protein family UPF0029
C628_RS10360	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C628_RS10395	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C628_RS10405	COG0488	(ABC) transporter
C628_RS10415	COG0252	asparaginase activity
C628_RS10445	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C628_RS10455	COG3599	regulation of cell shape
C628_RS10465	COG1799	cell septum assembly
C628_RS10470	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C628_RS10475	COG1496	oxidoreductase activity
C628_RS10480	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C628_RS10485	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C628_RS10495	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C628_RS10505	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C628_RS10520	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C628_RS10525	COG0768	penicillin binding
C628_RS10535	COG0275	rRNA processing
C628_RS10555	COG0456	acetyltransferase
C628_RS10565	COG0142	geranyltranstransferase activity
C628_RS10580	COG0515	serine threonine protein kinase
C628_RS10580	COG2815	serine threonine protein kinase
C628_RS10595	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C628_RS10630	COG1940	carbohydrate kinase activity
C628_RS10635	COG0438	transferase activity, transferring glycosyl groups
C628_RS10650	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C628_RS10655	COG0723	plastoquinol--plastocyanin reductase activity
C628_RS10660	COG2010	Cytochrome c
C628_RS10665	COG1845	cytochrome c oxidase, subunit III
C628_RS10680	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C628_RS10705	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C628_RS10720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C628_RS10725	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C628_RS10735	COG0508	dehydrogenase complex catalyzes the overall conversion of
C628_RS10765	COG0174	glutamine synthetase
C628_RS10785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C628_RS10795	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C628_RS10825	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C628_RS10830	COG0174	glutamine synthetase
C628_RS10845	COG2801	Transposase and inactivated derivatives
C628_RS10870	COG0557	exoribonuclease II activity
C628_RS10895	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C628_RS10895	COG3323	Protein of unknown function (DUF1653)
C628_RS10940	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C628_RS10970	COG0596	Alpha beta hydrolase
C628_RS10975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C628_RS11030	COG2826	transposase and inactivated derivatives, IS30 family
C628_RS11050	COG3387	PFAM Glycoside hydrolase 15-related
C628_RS11060	COG0358	DNA primase activity
C628_RS11075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C628_RS11085	COG2801	Transposase and inactivated derivatives
C628_RS11100	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C628_RS11125	COG0423	glycine-tRNA ligase activity
C628_RS11150	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C628_RS11155	COG1381	Involved in DNA repair and RecF pathway recombination
C628_RS11160	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C628_RS11185	COG0484	heat shock protein binding
C628_RS11225	COG1132	(ABC) transporter
C628_RS11245	COG0366	Alpha amylase catalytic
C628_RS11280	COG1114	Component of the transport system for branched-chain amino acids
C628_RS11285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C628_RS11295	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C628_RS11310	COG0247	lactate metabolic process
C628_RS11310	COG0277	FAD linked oxidase domain protein
C628_RS11335	COG0747	negative chemotaxis
C628_RS11340	COG0601	transmembrane transport
C628_RS11345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C628_RS11360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C628_RS11370	COG0385	Bile acid
C628_RS11375	COG0676	glucose-6-phosphate 1-epimerase activity
C628_RS11380	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C628_RS11385	COG2224	Isocitrate lyase
C628_RS11400	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C628_RS11430	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C628_RS11430	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C628_RS11440	COG0481	GTPase activity
C628_RS11455	COG1280	lysine exporter protein (LysE YggA)
C628_RS11480	COG1307	EDD domain protein, DegV family
C628_RS11485	COG0406	alpha-ribazole phosphatase activity
C628_RS11495	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C628_RS11510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C628_RS11515	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C628_RS11520	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C628_RS11555	COG1530	ribonuclease E activity
C628_RS11600	COG0285	dihydrofolate synthase activity
C628_RS11605	COG0525	valine-tRNA ligase activity
C628_RS11615	COG0443	Heat shock 70 kDa protein
C628_RS11625	COG0039	L-malate dehydrogenase activity
C628_RS11680	COG1414	Transcriptional regulator
C628_RS11685	COG0183	Belongs to the thiolase family
C628_RS11705	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C628_RS11710	COG3485	protocatechuate 3,4-dioxygenase
C628_RS11715	COG3485	protocatechuate 3,4-dioxygenase
C628_RS11725	COG4829	muconolactone delta-isomerase
C628_RS11730	COG4948	Mandelate Racemase Muconate Lactonizing
C628_RS11735	COG3485	protocatechuate 3,4-dioxygenase
C628_RS11740	COG4638	Rieske (2fe-2S)
C628_RS11755	COG1028	Short-chain dehydrogenase reductase Sdr
C628_RS11765	COG2814	Major facilitator Superfamily
C628_RS11775	COG0740	serine-type endopeptidase activity
C628_RS11780	COG0740	serine-type endopeptidase activity
C628_RS11845	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C628_RS11875	COG4172	Belongs to the ABC transporter superfamily
C628_RS11880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C628_RS11885	COG0601	transmembrane transport
C628_RS11890	COG0747	negative chemotaxis
C628_RS11900	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C628_RS11915	COG4221	oxidoreductase activity
C628_RS11930	COG1119	ATPase activity
C628_RS11935	COG0668	transmembrane transport
C628_RS12020	COG3842	ATPase activity
C628_RS12025	COG0463	Glycosyl transferase, family 2
C628_RS12045	COG1012	belongs to the aldehyde dehydrogenase family
C628_RS12070	COG1335	isochorismatase
C628_RS12075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C628_RS12080	COG1606	tRNA processing
C628_RS12085	COG1691	(AIR) carboxylase
C628_RS12095	COG3622	Belongs to the hyi family
C628_RS12100	COG4221	oxidoreductase activity
C628_RS12115	COG1376	ErfK ybiS ycfS ynhG family protein
C628_RS12155	COG2066	Belongs to the glutaminase family
C628_RS12165	COG1609	Transcriptional regulator
C628_RS12170	COG1102	Psort location Cytoplasmic, score
C628_RS12170	COG1904	glucuronate isomerase
C628_RS12175	COG3265	gluconokinase activity
C628_RS12185	COG1335	isochorismatase
C628_RS12210	COG2814	Major facilitator Superfamily
C628_RS12235	COG1028	Short-chain dehydrogenase reductase Sdr
C628_RS12240	COG3835	regulator
C628_RS12250	COG3311	Transcriptional regulator
C628_RS12255	COG1569	PIN domain
C628_RS12300	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C628_RS12305	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C628_RS12325	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C628_RS12340	COG0739	heme binding
C628_RS12395	COG0739	heme binding
C628_RS12425	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C628_RS12470	COG1234	tRNA 3'-trailer cleavage
C628_RS12475	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C628_RS12495	COG3191	aminopeptidase activity
C628_RS12515	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C628_RS12540	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C628_RS12570	COG2186	Transcriptional regulator
C628_RS12585	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C628_RS12605	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C628_RS12620	COG0604	alcohol dehydrogenase
C628_RS12625	COG2079	MmgE PrpD family protein
C628_RS12650	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C628_RS12655	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C628_RS12680	COG1136	(ABC) transporter
C628_RS12740	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C628_RS12750	COG2197	response regulator
C628_RS12765	COG1045	serine acetyltransferase
C628_RS12790	COG0045	succinate-CoA ligase (ADP-forming) activity
C628_RS12805	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C628_RS12835	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C628_RS12855	COG0456	acetyltransferase
C628_RS12865	COG1597	lipid kinase activity
C628_RS12895	COG2801	Transposase and inactivated derivatives
C628_RS12900	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C628_RS12930	COG0047	phosphoribosylformylglycinamidine synthase activity
C628_RS12935	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C628_RS12940	COG0386	Belongs to the glutathione peroxidase family
C628_RS12965	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C628_RS12970	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C628_RS12975	COG0436	Aminotransferase
C628_RS12980	COG0151	Belongs to the GarS family
C628_RS12985	COG0537	adenosine 5'-monophosphoramidase activity
C628_RS12990	COG2267	carboxylic ester hydrolase activity
C628_RS12990	COG2226	methyltransferase
C628_RS12995	COG3104	oligopeptide transport
C628_RS13005	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C628_RS13010	COG2205	protein histidine kinase activity
C628_RS13015	COG0745	RESPONSE REGULATOR receiver
C628_RS13020	COG0789	Transcriptional regulator
C628_RS13030	COG0028	Belongs to the TPP enzyme family
C628_RS13040	COG1309	transcriptional regulator
C628_RS13055	COG1053	succinate dehydrogenase
C628_RS13060	COG1053	succinate dehydrogenase
C628_RS13065	COG1063	alcohol dehydrogenase
C628_RS13075	COG0477	Major facilitator Superfamily
C628_RS13080	COG0583	DNA-binding transcription factor activity
C628_RS13085	COG1748	Saccharopine dehydrogenase
C628_RS13125	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C628_RS13140	COG1609	Transcriptional regulator
C628_RS13150	COG1121	(ABC) transporter
C628_RS13155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C628_RS13175	COG0673	inositol 2-dehydrogenase activity
C628_RS13180	COG0477	Major facilitator Superfamily
C628_RS13190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C628_RS13205	COG1621	beta-fructofuranosidase activity
C628_RS13215	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C628_RS13220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C628_RS13265	COG4608	Belongs to the ABC transporter superfamily
C628_RS13270	COG1280	lysine exporter protein (LysE YggA)
C628_RS13275	COG1522	sequence-specific DNA binding
C628_RS13285	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C628_RS13290	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C628_RS13305	COG2205	protein histidine kinase activity
C628_RS13310	COG2847	Copper chaperone PCu(A)C
C628_RS13315	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C628_RS13320	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C628_RS13365	COG0542	response to heat
C628_RS13380	COG2207	Transcriptional regulator
C628_RS13400	COG2814	Major facilitator Superfamily
C628_RS13410	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C628_RS13415	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C628_RS13435	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C628_RS13450	COG0302	gtp cyclohydrolase
C628_RS13455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C628_RS13465	COG0037	tRNA processing
C628_RS13475	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C628_RS13480	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C628_RS13485	COG3766	membrane
C628_RS13505	COG1263	PTS System
C628_RS13505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C628_RS13505	COG2190	(PTS) system
C628_RS13510	COG2190	(PTS) system
C628_RS13510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C628_RS13510	COG1263	PTS System
C628_RS13515	COG1263	PTS System
C628_RS13515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C628_RS13515	COG2190	(PTS) system
C628_RS13525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C628_RS13540	COG1012	belongs to the aldehyde dehydrogenase family
C628_RS13545	COG2326	polyphosphate kinase activity
C628_RS13555	COG0459	protein refolding
C628_RS13565	COG1100	Small GTP-binding protein
C628_RS13615	COG2111	Na H antiporter
C628_RS13615	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C628_RS13620	COG1006	Multisubunit Na H antiporter MnhC subunit
C628_RS13625	COG0651	ATP synthesis coupled electron transport
C628_RS13635	COG2212	antiporter activity
C628_RS13640	COG1320	monovalent cation:proton antiporter activity
C628_RS13665	COG0242	peptide deformylase activity
C628_RS13685	COG2814	Major facilitator Superfamily
C628_RS13705	COG1131	(ABC) transporter
C628_RS13725	COG2801	Transposase and inactivated derivatives
C628_RS13745	COG2826	transposase and inactivated derivatives, IS30 family
C628_RS13750	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C628_RS13755	COG0280	phosphate acetyltransferase
C628_RS13800	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C628_RS13805	COG4129	membrane
C628_RS13810	COG0191	fructose-bisphosphate aldolase activity
C628_RS13830	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C628_RS13840	COG2897	thiosulfate sulfurtransferase activity
C628_RS13865	COG0542	response to heat
C628_RS13875	COG0640	Transcriptional regulator
C628_RS13935	COG1012	belongs to the aldehyde dehydrogenase family
C628_RS13940	COG0789	Transcriptional regulator
C628_RS13945	COG0484	heat shock protein binding
C628_RS13950	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C628_RS13955	COG0443	Heat shock 70 kDa protein
C628_RS14010	COG0730	response to heat
C628_RS14035	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C628_RS14080	COG1162	GTPase activity
C628_RS14090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C628_RS14100	COG2801	Transposase and inactivated derivatives
C628_RS14110	COG1122	ATPase activity
C628_RS14180	COG2818	Glycosylase
C628_RS14185	COG1017	nitric oxide dioxygenase activity
C628_RS14185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C628_RS14195	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C628_RS14200	COG3711	transcriptional antiterminator
C628_RS14230	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C628_RS14255	COG1472	Belongs to the glycosyl hydrolase 3 family
C628_RS14270	COG4981	capsule polysaccharide biosynthetic process
C628_RS14295	COG0438	transferase activity, transferring glycosyl groups
C628_RS14305	COG0500	methyltransferase
C628_RS14310	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C628_RS14345	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C628_RS14350	COG3321	synthase
C628_RS14350	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C628_RS14350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C628_RS14355	COG0318	PFAM AMP-dependent synthetase and ligase
C628_RS14360	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
C628_RS14370	COG5479	isomerase activity
C628_RS14370	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C628_RS14385	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C628_RS14390	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C628_RS14395	COG0671	phosphoesterase, PA-phosphatase related
C628_RS14400	COG1216	Glycosyl transferase, family 2
C628_RS14410	COG0671	phosphoesterase, PA-phosphatase related
C628_RS14440	COG0561	phosphatase activity
C628_RS14450	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C628_RS14455	COG2188	Transcriptional regulator
C628_RS14475	COG0077	Prephenate dehydratase
C628_RS14495	COG1316	TRANSCRIPTIONal
C628_RS14525	COG2610	gluconate transmembrane transporter activity
C628_RS14530	COG0469	pyruvate kinase activity
C628_RS14535	COG0039	L-malate dehydrogenase activity
C628_RS14555	COG2188	Transcriptional regulator
C628_RS14560	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C628_RS14570	COG0477	Major facilitator Superfamily
C628_RS14585	COG1115	amino acid carrier protein
C628_RS14590	COG2186	Transcriptional regulator
C628_RS14605	COG1012	belongs to the aldehyde dehydrogenase family
C628_RS14610	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C628_RS14645	COG2814	Major facilitator Superfamily
C628_RS14675	COG2197	response regulator
C628_RS14695	COG3764	Sortase (surface protein transpeptidase)
C628_RS14700	COG0706	membrane insertase activity
C628_RS14720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C628_RS14730	COG0564	pseudouridine synthase activity
C628_RS14765	COG1842	Phage shock protein A
C628_RS14795	COG1063	alcohol dehydrogenase
C628_RS14800	COG0662	Cupin 2, conserved barrel domain protein
C628_RS14810	COG2608	mercury ion transmembrane transporter activity
C628_RS14875	COG2217	Heavy metal translocating P-type atpase
C628_RS14885	COG2205	protein histidine kinase activity
C628_RS14890	COG0745	RESPONSE REGULATOR receiver
C628_RS14900	COG2132	Multicopper oxidase
C628_RS14965	COG0789	Transcriptional regulator
C628_RS14990	COG0531	amino acid
C628_RS14995	COG2132	Multicopper oxidase
C628_RS15015	COG2608	mercury ion transmembrane transporter activity
C628_RS15040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C628_RS15050	COG0477	Major facilitator Superfamily
C628_RS15060	COG1695	Transcriptional regulator
C628_RS15070	COG0305	Participates in initiation and elongation during chromosome replication
C628_RS15080	COG0629	single-stranded DNA binding
C628_RS15085	COG0360	Binds together with S18 to 16S ribosomal RNA
C628_RS15100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C628_RS15110	COG1846	Transcriptional regulator
C628_RS15140	COG1136	(ABC) transporter
C628_RS15150	COG1260	myo-inositol-1-phosphate synthase
C628_RS15160	COG4868	Belongs to the UPF0371 family
C628_RS15170	COG2801	Transposase and inactivated derivatives
C628_RS15175	COG2826	transposase and inactivated derivatives, IS30 family
C628_RS15180	COG0783	Belongs to the Dps family
C628_RS15185	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C628_RS15190	COG1690	Belongs to the RtcB family
C628_RS15195	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C628_RS15210	COG2801	Transposase and inactivated derivatives
C628_RS15260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C628_RS15265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C628_RS15280	COG0778	Nitroreductase
C628_RS15295	COG2832	Protein of unknown function (DUF454)
C628_RS15310	COG0179	Fumarylacetoacetate (FAA) hydrolase
C628_RS15325	COG2814	Major facilitator Superfamily
C628_RS15330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C628_RS15355	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C628_RS15360	COG0512	Glutamine amidotransferase of anthranilate synthase
C628_RS15370	COG0134	indole-3-glycerol-phosphate synthase activity
C628_RS15370	COG0135	phosphoribosylanthranilate isomerase activity
C628_RS15375	COG0133	tryptophan synthase activity
C628_RS15380	COG0159	tryptophan synthase activity
C628_RS15390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C628_RS15395	COG1131	(ABC) transporter
C628_RS15425	COG0640	Transcriptional regulator
C628_RS15430	COG1902	pentaerythritol trinitrate reductase activity
C628_RS15435	COG0702	epimerase
C628_RS15465	COG3104	oligopeptide transport
C628_RS15470	COG1309	transcriptional regulator
C628_RS15480	COG1454	alcohol dehydrogenase
C628_RS15485	COG2814	Major facilitator Superfamily
C628_RS15490	COG1414	Transcriptional regulator
C628_RS15495	COG0673	inositol 2-dehydrogenase activity
C628_RS15505	COG0673	inositol 2-dehydrogenase activity
C628_RS15510	COG0673	inositol 2-dehydrogenase activity
C628_RS15520	COG0477	Major facilitator Superfamily
C628_RS15545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C628_RS15570	COG0351	phosphomethylpyrimidine kinase
C628_RS15580	COG2608	mercury ion transmembrane transporter activity
C628_RS15585	COG1687	branched-chain amino acid
C628_RS15590	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C628_RS15595	COG1678	Uncharacterized ACR, COG1678
C628_RS15600	COG0617	tRNA 3'-terminal CCA addition
C628_RS15620	COG1595	DNA-templated transcription, initiation
C628_RS15630	COG3118	belongs to the thioredoxin family
C628_RS15635	COG3409	Peptidoglycan-binding domain 1 protein
C628_RS15635	COG0860	N-Acetylmuramoyl-L-alanine amidase
C628_RS15650	COG1192	Involved in chromosome partitioning
C628_RS15665	COG0594	ribonuclease P activity