locus-tag	class	description
CXR29_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CXR29_RS00010	COG0592	DNA-directed DNA polymerase activity
CXR29_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CXR29_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
CXR29_RS00025	COG0187	DNA topoisomerase II activity
CXR29_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CXR29_RS00050	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CXR29_RS00055	COG2814	Major facilitator Superfamily
CXR29_RS00070	COG1321	iron dependent repressor
CXR29_RS00075	COG1012	belongs to the aldehyde dehydrogenase family
CXR29_RS00095	COG2837	iron assimilation
CXR29_RS00115	COG0793	Belongs to the peptidase S41A family
CXR29_RS00115	COG4946	Tricorn protease homolog
CXR29_RS00120	COG0018	arginyl-trna synthetase
CXR29_RS00125	COG2807	transmembrane transport
CXR29_RS00135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CXR29_RS00150	COG3764	Sortase (surface protein transpeptidase)
CXR29_RS00170	COG0515	serine threonine protein kinase
CXR29_RS00175	COG0515	serine threonine protein kinase
CXR29_RS00180	COG0768	penicillin binding
CXR29_RS00210	COG3425	synthase
CXR29_RS00250	COG0277	FAD linked oxidase domain protein
CXR29_RS00260	COG1064	alcohol dehydrogenase
CXR29_RS00300	COG0673	inositol 2-dehydrogenase activity
CXR29_RS00310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CXR29_RS00320	COG2233	PERMEase
CXR29_RS00340	COG1115	amino acid carrier protein
CXR29_RS00380	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CXR29_RS00390	COG1012	belongs to the aldehyde dehydrogenase family
CXR29_RS00415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CXR29_RS00420	COG1960	acyl-CoA dehydrogenase activity
CXR29_RS00425	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXR29_RS00445	COG1522	sequence-specific DNA binding
CXR29_RS00450	COG2086	electron transfer activity
CXR29_RS00455	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CXR29_RS00475	COG1414	Transcriptional regulator
CXR29_RS00480	COG1802	Transcriptional regulator
CXR29_RS00485	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CXR29_RS00510	COG1760	l-serine dehydratase
CXR29_RS00540	COG1414	Transcriptional regulator
CXR29_RS00560	COG0640	Transcriptional regulator
CXR29_RS00585	COG2197	response regulator
CXR29_RS00590	COG4585	Histidine kinase
CXR29_RS00595	COG0515	serine threonine protein kinase
CXR29_RS00600	COG1136	(ABC) transporter
CXR29_RS00600	COG0577	efflux transmembrane transporter activity
CXR29_RS00620	COG0477	Major facilitator Superfamily
CXR29_RS00635	COG2226	methyltransferase
CXR29_RS00650	COG0351	phosphomethylpyrimidine kinase
CXR29_RS00685	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CXR29_RS00690	COG0477	Major facilitator Superfamily
CXR29_RS00695	COG1012	belongs to the aldehyde dehydrogenase family
CXR29_RS00695	COG2030	dehydratase
CXR29_RS00700	COG1597	lipid kinase activity
CXR29_RS00710	COG0277	FAD linked oxidase domain protein
CXR29_RS00710	COG0277	FAD linked oxidase domain protein
CXR29_RS00740	COG3396	Phenylacetate-CoA oxygenase
CXR29_RS00745	COG3460	Phenylacetate-CoA oxygenase
CXR29_RS00750	COG3396	Phenylacetate-CoA oxygenase
CXR29_RS00755	COG2151	metal-sulfur cluster biosynthetic enzyme
CXR29_RS00760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CXR29_RS00770	COG1024	Enoyl-CoA hydratase
CXR29_RS00775	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXR29_RS00780	COG1024	Enoyl-CoA hydratase
CXR29_RS00785	COG0398	Pfam SNARE associated Golgi protein
CXR29_RS00790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CXR29_RS00810	COG1473	amidohydrolase
CXR29_RS00825	COG4638	Rieske (2fe-2S)
CXR29_RS00845	COG0318	PFAM AMP-dependent synthetase and ligase
CXR29_RS00850	COG1028	Short-chain dehydrogenase reductase Sdr
CXR29_RS00855	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CXR29_RS00865	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CXR29_RS00865	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CXR29_RS00870	COG1028	Short-chain dehydrogenase reductase Sdr
CXR29_RS00880	COG3619	membrane
CXR29_RS00885	COG0405	Gamma-glutamyltransferase
CXR29_RS00890	COG2188	Transcriptional regulator
CXR29_RS00910	COG0531	amino acid
CXR29_RS00920	COG0179	Fumarylacetoacetate (FAA) hydrolase
CXR29_RS00930	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXR29_RS00940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CXR29_RS00945	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXR29_RS00975	COG0431	NADPH-dependent FMN reductase
CXR29_RS01005	COG3836	Belongs to the HpcH HpaI aldolase family
CXR29_RS01010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CXR29_RS01015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CXR29_RS01030	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CXR29_RS01055	COG2409	Drug exporters of the RND superfamily
CXR29_RS01060	COG1846	Transcriptional regulator
CXR29_RS01090	COG0657	acetylesterase activity
CXR29_RS01105	COG0656	L-ascorbic acid biosynthetic process
CXR29_RS01110	COG2801	Transposase and inactivated derivatives
CXR29_RS01120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXR29_RS01155	COG1074	ATP-dependent DNA helicase activity
CXR29_RS01215	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CXR29_RS01240	COG1966	Carbon starvation protein
CXR29_RS01250	COG0003	Pfam Anion-transporting ATPase
CXR29_RS01280	COG0436	Aminotransferase
CXR29_RS01315	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CXR29_RS01325	COG0583	DNA-binding transcription factor activity
CXR29_RS01330	COG0477	Major facilitator Superfamily
CXR29_RS01335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CXR29_RS01340	COG0154	amidase activity
CXR29_RS01345	COG0477	Major facilitator Superfamily
CXR29_RS01350	COG0154	amidase activity
CXR29_RS01360	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CXR29_RS01365	COG1960	acyl-CoA dehydrogenase activity
CXR29_RS01375	COG0183	Belongs to the thiolase family
CXR29_RS01380	COG0583	DNA-binding transcription factor activity
CXR29_RS01385	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CXR29_RS01390	COG1228	amidohydrolase
CXR29_RS01395	COG2986	histidine ammonia-lyase
CXR29_RS01405	COG0402	S-adenosylhomocysteine deaminase activity
CXR29_RS01415	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CXR29_RS01435	COG1309	transcriptional regulator
CXR29_RS01460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CXR29_RS01495	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CXR29_RS01510	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CXR29_RS01540	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CXR29_RS01570	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CXR29_RS01585	COG1414	Transcriptional regulator
CXR29_RS01590	COG1414	Transcriptional regulator
CXR29_RS01600	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CXR29_RS01605	COG0531	amino acid
CXR29_RS01610	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CXR29_RS01615	COG0569	domain protein
CXR29_RS01630	COG0579	oxidoreductase
CXR29_RS01650	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CXR29_RS01655	COG0589	response to stress
CXR29_RS01660	COG0277	FAD linked oxidase domain protein
CXR29_RS01660	COG0247	lactate metabolic process
CXR29_RS01720	COG1960	acyl-CoA dehydrogenase activity
CXR29_RS01735	COG1028	Short-chain dehydrogenase reductase Sdr
CXR29_RS01740	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CXR29_RS01740	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CXR29_RS01745	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CXR29_RS01750	COG0509	glycine decarboxylation via glycine cleavage system
CXR29_RS01760	COG0456	acetyltransferase
CXR29_RS01770	COG1917	Cupin 2, conserved barrel domain protein
CXR29_RS01780	COG5285	phytanoyl-CoA dioxygenase
CXR29_RS01785	COG1115	amino acid carrier protein
CXR29_RS01790	COG0584	glycerophosphoryl diester phosphodiesterase
CXR29_RS01800	COG1331	Highly conserved protein containing a thioredoxin domain
CXR29_RS01820	COG1362	aminopeptidase activity
CXR29_RS01830	COG3590	peptidase
CXR29_RS01835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CXR29_RS01850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CXR29_RS01855	COG0583	DNA-binding transcription factor activity
CXR29_RS01880	COG0277	FAD linked oxidase domain protein
CXR29_RS01890	COG1476	TRANSCRIPTIONal
CXR29_RS01900	COG1316	TRANSCRIPTIONal
CXR29_RS01920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CXR29_RS01920	COG0425	Belongs to the sulfur carrier protein TusA family
CXR29_RS01945	COG1134	teichoic acid transport
CXR29_RS01945	COG1388	LysM domain
CXR29_RS01960	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CXR29_RS01970	COG0730	response to heat
CXR29_RS01975	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CXR29_RS01980	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CXR29_RS01995	COG0529	Catalyzes the synthesis of activated sulfate
CXR29_RS01995	COG2895	sulfate adenylyltransferase (ATP) activity
CXR29_RS02000	COG1648	precorrin-2 dehydrogenase activity
CXR29_RS02000	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CXR29_RS02015	COG3311	Transcriptional regulator
CXR29_RS02030	COG0531	amino acid
CXR29_RS02050	COG0589	response to stress
CXR29_RS02065	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CXR29_RS02070	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CXR29_RS02085	COG1215	transferase activity, transferring glycosyl groups
CXR29_RS02090	COG1086	Polysaccharide biosynthesis protein
CXR29_RS02095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CXR29_RS02110	COG1682	transport, permease protein
CXR29_RS02115	COG1134	teichoic acid transport
CXR29_RS02125	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CXR29_RS02130	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CXR29_RS02130	COG0463	Glycosyl transferase, family 2
CXR29_RS02150	COG0477	Major facilitator Superfamily
CXR29_RS02155	COG2353	YceI-like domain
CXR29_RS02160	COG0477	Major facilitator Superfamily
CXR29_RS02180	COG4166	transmembrane transport
CXR29_RS02190	COG1120	ATPase activity
CXR29_RS02205	COG1132	(ABC) transporter
CXR29_RS02205	COG2375	cellular response to nickel ion
CXR29_RS02220	COG3547	Transposase (IS116 IS110 IS902 family)
CXR29_RS02245	COG1301	dicarboxylic acid transport
CXR29_RS02275	COG3290	protein histidine kinase activity
CXR29_RS02280	COG2197	response regulator
CXR29_RS02300	COG0640	Transcriptional regulator
CXR29_RS02305	COG0798	PFAM Bile acid sodium symporter
CXR29_RS02310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CXR29_RS02335	COG1764	response to oxidative stress
CXR29_RS02340	COG1846	Transcriptional regulator
CXR29_RS02355	COG0363	glucosamine-6-phosphate deaminase activity
CXR29_RS02360	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CXR29_RS02370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXR29_RS02375	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CXR29_RS02390	COG1960	acyl-CoA dehydrogenase activity
CXR29_RS02420	COG0477	Major facilitator Superfamily
CXR29_RS02430	COG0640	Transcriptional regulator
CXR29_RS02435	COG1902	pentaerythritol trinitrate reductase activity
CXR29_RS02440	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CXR29_RS02445	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CXR29_RS02455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXR29_RS02460	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CXR29_RS02520	COG0477	Major facilitator Superfamily
CXR29_RS02560	COG1309	transcriptional regulator
CXR29_RS02565	COG2076	Multidrug Resistance protein
CXR29_RS02575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CXR29_RS02580	COG3119	arylsulfatase activity
CXR29_RS02610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CXR29_RS02615	COG1054	Belongs to the UPF0176 family
CXR29_RS02620	COG1090	epimerase
CXR29_RS02695	COG0047	phosphoribosylformylglycinamidine synthase activity
CXR29_RS02700	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CXR29_RS02705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXR29_RS02710	COG1177	transmembrane transport
CXR29_RS02725	COG3842	ATPase activity
CXR29_RS02735	COG0151	Belongs to the GarS family
CXR29_RS02750	COG1012	belongs to the aldehyde dehydrogenase family
CXR29_RS02775	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CXR29_RS02805	COG0697	spore germination
CXR29_RS02835	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CXR29_RS02870	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CXR29_RS02875	COG2801	Transposase and inactivated derivatives
CXR29_RS02895	COG2813	Specifically methylates the guanine in position
CXR29_RS02895	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CXR29_RS02900	COG0583	DNA-binding transcription factor activity
CXR29_RS02910	COG1228	amidohydrolase
CXR29_RS02920	COG1132	(ABC) transporter
CXR29_RS02930	COG2239	Acts as a magnesium transporter
CXR29_RS02940	COG0589	response to stress
CXR29_RS02945	COG2814	Major facilitator Superfamily
CXR29_RS02960	COG0300	oxidoreductase activity
CXR29_RS02965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CXR29_RS02990	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CXR29_RS02995	COG1739	Uncharacterized protein family UPF0029
CXR29_RS03005	COG2801	Transposase and inactivated derivatives
CXR29_RS03025	COG0028	Belongs to the TPP enzyme family
CXR29_RS03035	COG3938	Belongs to the proline racemase family
CXR29_RS03055	COG0765	amino acid transport
CXR29_RS03065	COG0477	Major facilitator Superfamily
CXR29_RS03070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CXR29_RS03075	COG2814	Major facilitator Superfamily
CXR29_RS03080	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CXR29_RS03085	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CXR29_RS03090	COG3485	protocatechuate 3,4-dioxygenase
CXR29_RS03095	COG3485	protocatechuate 3,4-dioxygenase
CXR29_RS03110	COG2079	MmgE PrpD family protein
CXR29_RS03115	COG2391	methyltransferase activity
CXR29_RS03120	COG0425	Belongs to the sulfur carrier protein TusA family
CXR29_RS03140	COG2197	response regulator
CXR29_RS03145	COG4585	Histidine kinase
CXR29_RS03155	COG2132	Multicopper oxidase
CXR29_RS03170	COG2357	RelA SpoT domain protein
CXR29_RS03180	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CXR29_RS03200	COG1715	Restriction endonuclease
CXR29_RS03240	COG2814	Major facilitator Superfamily
CXR29_RS03260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CXR29_RS03265	COG3842	ATPase activity
CXR29_RS03285	COG2188	Transcriptional regulator
CXR29_RS03300	COG0572	uridine kinase
CXR29_RS03330	COG0477	Major facilitator Superfamily
CXR29_RS03345	COG1012	belongs to the aldehyde dehydrogenase family
CXR29_RS03355	COG3971	2-oxopent-4-enoate hydratase activity
CXR29_RS03390	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CXR29_RS03400	COG0590	tRNA wobble adenosine to inosine editing
CXR29_RS03410	COG2252	PERMEase
CXR29_RS03430	COG0402	S-adenosylhomocysteine deaminase activity
CXR29_RS03440	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CXR29_RS03455	COG1929	Belongs to the glycerate kinase type-1 family
CXR29_RS03480	COG1414	Transcriptional regulator
CXR29_RS03500	COG0579	oxidoreductase
CXR29_RS03505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CXR29_RS03510	COG0277	FAD linked oxidase domain protein
CXR29_RS03525	COG2040	homocysteine
CXR29_RS03530	COG0343	queuine tRNA-ribosyltransferase activity
CXR29_RS03545	COG0628	permease
CXR29_RS03570	COG1012	belongs to the aldehyde dehydrogenase family
CXR29_RS03585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CXR29_RS03595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXR29_RS03625	COG0542	response to heat
CXR29_RS03645	COG0740	serine-type endopeptidase activity
CXR29_RS03650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CXR29_RS03675	COG2385	sporulation resulting in formation of a cellular spore
CXR29_RS03680	COG0693	protein deglycase activity
CXR29_RS03695	COG4941	Belongs to the sigma-70 factor family
CXR29_RS03700	COG1289	transmembrane transporter activity
CXR29_RS03740	COG0010	Belongs to the arginase family
CXR29_RS03760	COG0656	L-ascorbic acid biosynthetic process
CXR29_RS03835	COG1917	Cupin 2, conserved barrel domain protein
CXR29_RS03840	COG0456	acetyltransferase
CXR29_RS03870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CXR29_RS03895	COG1192	Involved in chromosome partitioning
CXR29_RS03920	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CXR29_RS03965	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CXR29_RS03985	COG1121	(ABC) transporter
CXR29_RS03995	COG1408	metallophosphoesterase
CXR29_RS04000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CXR29_RS04025	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CXR29_RS04055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CXR29_RS04105	COG1205	dead DEAH box helicase
CXR29_RS04105	COG1111	helicase
CXR29_RS04115	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CXR29_RS04115	COG1754	DNA topoisomerase type I activity
CXR29_RS04130	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CXR29_RS04195	COG3344	reverse transcriptase
CXR29_RS04220	COG0183	Belongs to the thiolase family
CXR29_RS04225	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXR29_RS04225	COG1024	Enoyl-CoA hydratase
CXR29_RS04230	COG0604	alcohol dehydrogenase
CXR29_RS04235	COG1309	transcriptional regulator
CXR29_RS04240	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CXR29_RS04250	COG1960	acyl-CoA dehydrogenase activity
CXR29_RS04255	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXR29_RS04270	COG0640	Transcriptional regulator
CXR29_RS04280	COG2030	dehydratase
CXR29_RS04290	COG0242	peptide deformylase activity
CXR29_RS04300	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CXR29_RS04310	COG0477	Major facilitator Superfamily
CXR29_RS04315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CXR29_RS04340	COG2027	D-alanyl-D-alanine carboxypeptidase
CXR29_RS04350	COG0037	tRNA processing
CXR29_RS04360	COG2807	transmembrane transport
CXR29_RS04365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CXR29_RS04370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CXR29_RS04375	COG0302	gtp cyclohydrolase
CXR29_RS04385	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CXR29_RS04385	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CXR29_RS04410	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CXR29_RS04425	COG0542	response to heat
CXR29_RS04430	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CXR29_RS04435	COG1194	a g-specific adenine glycosylase
CXR29_RS04465	COG1012	belongs to the aldehyde dehydrogenase family
CXR29_RS04475	COG0583	DNA-binding transcription factor activity
CXR29_RS04485	COG2226	methyltransferase
CXR29_RS04505	COG1122	ATPase activity
CXR29_RS04510	COG4721	ABC-type cobalt transport system, permease component
CXR29_RS04530	COG2079	MmgE PrpD family protein
CXR29_RS04535	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CXR29_RS04545	COG1024	Enoyl-CoA hydratase
CXR29_RS04550	COG0248	Ppx GppA phosphatase
CXR29_RS04555	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CXR29_RS04560	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CXR29_RS04565	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CXR29_RS04575	COG1082	Xylose isomerase domain protein TIM barrel
CXR29_RS04580	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CXR29_RS04585	COG2197	response regulator
CXR29_RS04595	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CXR29_RS04610	COG0569	domain protein
CXR29_RS04615	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CXR29_RS04620	COG0123	including yeast histone deacetylase and acetoin utilization protein
CXR29_RS04635	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CXR29_RS04640	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CXR29_RS04650	COG0113	porphobilinogen synthase activity
CXR29_RS04660	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CXR29_RS04665	COG0406	alpha-ribazole phosphatase activity
CXR29_RS04675	COG0785	Cytochrome C biogenesis protein
CXR29_RS04680	COG1333	cytochrome c biogenesis protein
CXR29_RS04685	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CXR29_RS04710	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CXR29_RS04715	COG4948	Mandelate Racemase Muconate Lactonizing
CXR29_RS04730	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CXR29_RS04735	COG2161	toxin-antitoxin pair type II binding
CXR29_RS04740	COG4115	mRNA cleavage
CXR29_RS04745	COG1169	isochorismate synthase
CXR29_RS04750	COG2226	methyltransferase
CXR29_RS04760	COG0142	geranyltranstransferase activity
CXR29_RS04765	COG0701	Predicted permease
CXR29_RS04805	COG0584	glycerophosphoryl diester phosphodiesterase
CXR29_RS04840	COG2801	Transposase and inactivated derivatives
CXR29_RS04880	COG2801	Transposase and inactivated derivatives
CXR29_RS04895	COG0582	viral genome integration into host DNA
CXR29_RS04920	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CXR29_RS04965	COG2372	response to copper ion
CXR29_RS04965	COG1276	copper resistance
CXR29_RS04990	COG1129	ABC transporter
CXR29_RS05000	COG2801	Transposase and inactivated derivatives
CXR29_RS05005	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CXR29_RS05010	COG0431	NADPH-dependent FMN reductase
CXR29_RS05015	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CXR29_RS05020	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CXR29_RS05025	COG1780	Probably involved in ribonucleotide reductase function
CXR29_RS05035	COG1121	(ABC) transporter
CXR29_RS05040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CXR29_RS05050	COG1321	iron dependent repressor
CXR29_RS05080	COG0805	protein transport
CXR29_RS05085	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CXR29_RS05105	COG2030	dehydratase
CXR29_RS05115	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CXR29_RS05140	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CXR29_RS05145	COG0081	regulation of translation
CXR29_RS05165	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CXR29_RS05170	COG0222	ribosome binding
CXR29_RS05195	COG0085	RNA polymerase activity
CXR29_RS05200	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CXR29_RS05215	COG0463	Glycosyl transferase, family 2
CXR29_RS05220	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CXR29_RS05225	COG0745	RESPONSE REGULATOR receiver
CXR29_RS05230	COG2205	protein histidine kinase activity
CXR29_RS05240	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CXR29_RS05250	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CXR29_RS05255	COG0049	tRNA binding
CXR29_RS05260	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CXR29_RS05265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CXR29_RS05270	COG0051	transcription antitermination factor activity, RNA binding
CXR29_RS05275	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CXR29_RS05280	COG0088	Forms part of the polypeptide exit tunnel
CXR29_RS05285	COG0089	rRNA binding
CXR29_RS05290	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CXR29_RS05295	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CXR29_RS05300	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CXR29_RS05305	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CXR29_RS05310	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CXR29_RS05315	COG0255	Belongs to the universal ribosomal protein uL29 family
CXR29_RS05320	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CXR29_RS05325	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CXR29_RS05330	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CXR29_RS05335	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CXR29_RS05340	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CXR29_RS05345	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CXR29_RS05350	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CXR29_RS05355	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CXR29_RS05360	COG1841	ribosomal large subunit assembly
CXR29_RS05365	COG0200	Binds to the 23S rRNA
CXR29_RS05375	COG0563	adenylate kinase activity
CXR29_RS05380	COG0024	Methionine aminopeptidase
CXR29_RS05400	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CXR29_RS05405	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CXR29_RS05410	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CXR29_RS05415	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CXR29_RS05420	COG0202	RNA polymerase activity
CXR29_RS05425	COG0203	ribosomal protein L17
CXR29_RS05430	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CXR29_RS05460	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CXR29_RS05465	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CXR29_RS05475	COG2801	Transposase and inactivated derivatives
CXR29_RS05490	COG0180	Tryptophanyl-tRNA synthetase
CXR29_RS05520	COG1846	Transcriptional regulator
CXR29_RS05550	COG2801	Transposase and inactivated derivatives
CXR29_RS05560	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CXR29_RS05585	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CXR29_RS05595	COG1234	tRNA 3'-trailer cleavage
CXR29_RS05600	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CXR29_RS05605	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CXR29_RS05610	COG0747	negative chemotaxis
CXR29_RS05620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXR29_RS05630	COG0154	amidase activity
CXR29_RS05685	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CXR29_RS05695	COG2267	carboxylic ester hydrolase activity
CXR29_RS05705	COG0193	aminoacyl-tRNA hydrolase activity
CXR29_RS05725	COG3237	CsbD-like
CXR29_RS05740	COG0148	phosphopyruvate hydratase activity
CXR29_RS05780	COG1733	regulation of RNA biosynthetic process
CXR29_RS05795	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CXR29_RS05800	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CXR29_RS05805	COG0156	8-amino-7-oxononanoate synthase activity
CXR29_RS05810	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CXR29_RS05825	COG2326	polyphosphate kinase activity
CXR29_RS05860	COG1914	H( )-stimulated, divalent metal cation uptake system
CXR29_RS05865	COG1643	Atp-dependent helicase
CXR29_RS05875	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CXR29_RS05880	COG1260	myo-inositol-1-phosphate synthase
CXR29_RS05885	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CXR29_RS05910	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CXR29_RS05925	COG2207	Transcriptional regulator
CXR29_RS05930	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CXR29_RS05935	COG4608	Belongs to the ABC transporter superfamily
CXR29_RS05940	COG0444	Belongs to the ABC transporter superfamily
CXR29_RS05945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXR29_RS05950	COG0601	transmembrane transport
CXR29_RS05955	COG4166	transmembrane transport
CXR29_RS05960	COG0579	oxidoreductase
CXR29_RS05980	COG1120	ATPase activity
CXR29_RS06000	COG0318	PFAM AMP-dependent synthetase and ligase
CXR29_RS06030	COG0477	Major facilitator Superfamily
CXR29_RS06035	COG1349	DNA-binding transcription factor activity
CXR29_RS06040	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CXR29_RS06045	COG3395	kinase activity
CXR29_RS06050	COG2610	gluconate transmembrane transporter activity
CXR29_RS06055	COG1063	alcohol dehydrogenase
CXR29_RS06060	COG2217	Heavy metal translocating P-type atpase
CXR29_RS06065	COG2514	catechol 2,3-dioxygenase activity
CXR29_RS06075	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CXR29_RS06080	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CXR29_RS06105	COG1960	acyl-CoA dehydrogenase activity
CXR29_RS06115	COG2197	response regulator
CXR29_RS06120	COG4585	Histidine kinase
CXR29_RS06135	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CXR29_RS06170	COG4585	Histidine kinase
CXR29_RS06175	COG2197	response regulator
CXR29_RS06200	COG1285	pathogenesis
CXR29_RS06205	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CXR29_RS06215	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CXR29_RS06220	COG0477	Major facilitator Superfamily
CXR29_RS06230	COG0477	Major facilitator Superfamily
CXR29_RS06245	COG1802	Transcriptional regulator
CXR29_RS06255	COG2814	Major facilitator Superfamily
CXR29_RS06275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CXR29_RS06290	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CXR29_RS06300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CXR29_RS06300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CXR29_RS06330	COG1316	TRANSCRIPTIONal
CXR29_RS06335	COG0791	NLP P60 protein
CXR29_RS06340	COG1482	cell wall glycoprotein biosynthetic process
CXR29_RS06360	COG0778	Nitroreductase
CXR29_RS06360	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
CXR29_RS06390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CXR29_RS06395	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CXR29_RS06415	COG0714	Associated with various cellular activities
CXR29_RS06435	COG0745	RESPONSE REGULATOR receiver
CXR29_RS06440	COG5002	protein histidine kinase activity
CXR29_RS06440	COG5000	phosphorelay sensor kinase activity
CXR29_RS06445	COG5401	PFAM Sporulation and spore germination
CXR29_RS06455	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CXR29_RS06465	COG0653	protein targeting
CXR29_RS06510	COG2902	Dehydrogenase
CXR29_RS06545	COG4770	biotin carboxylase activity
CXR29_RS06550	COG0424	maF-like protein
CXR29_RS06565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CXR29_RS06575	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CXR29_RS06590	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CXR29_RS06595	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CXR29_RS06600	COG0114	fumarate hydratase activity
CXR29_RS06620	COG1722	exodeoxyribonuclease VII activity
CXR29_RS06625	COG1570	exodeoxyribonuclease VII activity
CXR29_RS06630	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CXR29_RS06635	COG1322	Protein conserved in bacteria
CXR29_RS06705	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXR29_RS06720	COG4716	Myosin-crossreactive antigen
CXR29_RS06730	COG0693	protein deglycase activity
CXR29_RS06735	COG0656	L-ascorbic acid biosynthetic process
CXR29_RS06800	COG2267	carboxylic ester hydrolase activity
CXR29_RS06815	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CXR29_RS06880	COG1122	ATPase activity
CXR29_RS06910	COG1435	thymidine kinase activity
CXR29_RS06935	COG2022	thiamine diphosphate biosynthetic process
CXR29_RS06945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXR29_RS06950	COG0352	thiamine-phosphate diphosphorylase activity
CXR29_RS06975	COG1309	transcriptional regulator
CXR29_RS06980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXR29_RS06980	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CXR29_RS06985	COG0833	amino acid
CXR29_RS07000	COG0596	Alpha beta hydrolase
CXR29_RS07015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXR29_RS07020	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXR29_RS07025	COG1120	ATPase activity
CXR29_RS07030	COG2354	Protein conserved in bacteria
CXR29_RS07090	COG0737	Belongs to the 5'-nucleotidase family
CXR29_RS07095	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CXR29_RS07110	COG0492	ferredoxin-NADP+ reductase activity
CXR29_RS07135	COG3012	SEC-C Motif Domain Protein
CXR29_RS07145	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CXR29_RS07165	COG0433	COG0433 Predicted ATPase
CXR29_RS07170	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CXR29_RS07180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXR29_RS07190	COG2091	lysine biosynthetic process via aminoadipic acid
CXR29_RS07195	COG5416	Lipopolysaccharide assembly protein A domain
CXR29_RS07200	COG2838	Isocitrate dehydrogenase
CXR29_RS07205	COG1435	thymidine kinase activity
CXR29_RS07215	COG1902	pentaerythritol trinitrate reductase activity
CXR29_RS07220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CXR29_RS07235	COG0601	transmembrane transport
CXR29_RS07240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXR29_RS07250	COG1217	gtp-binding protein TYPA
CXR29_RS07255	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CXR29_RS07260	COG2720	vancomycin resistance protein
CXR29_RS07295	COG1611	Belongs to the LOG family
CXR29_RS07300	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CXR29_RS07320	COG4122	O-methyltransferase activity
CXR29_RS07330	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CXR29_RS07345	COG2239	Acts as a magnesium transporter
CXR29_RS07355	COG3191	aminopeptidase activity
CXR29_RS07360	COG0006	proline dipeptidase activity
CXR29_RS07370	COG0513	Belongs to the DEAD box helicase family
CXR29_RS07435	COG3480	Lon protease (S16) C-terminal proteolytic domain
CXR29_RS07440	COG1615	UPF0182 protein
CXR29_RS07460	COG0483	inositol monophosphate 1-phosphatase activity
CXR29_RS07465	COG1162	GTPase activity
CXR29_RS07470	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CXR29_RS07480	COG1595	DNA-templated transcription, initiation
CXR29_RS07500	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXR29_RS07500	COG0567	Dehydrogenase, E1 component
CXR29_RS07530	COG0577	efflux transmembrane transporter activity
CXR29_RS07530	COG1136	(ABC) transporter
CXR29_RS07535	COG0577	efflux transmembrane transporter activity
CXR29_RS07540	COG2807	transmembrane transport
CXR29_RS07550	COG0019	diaminopimelate decarboxylase activity
CXR29_RS07555	COG0460	homoserine dehydrogenase
CXR29_RS07565	COG0083	homoserine kinase activity
CXR29_RS07575	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CXR29_RS07590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CXR29_RS07600	COG0356	it plays a direct role in the translocation of protons across the membrane
CXR29_RS07605	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CXR29_RS07610	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CXR29_RS07615	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CXR29_RS07620	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CXR29_RS07625	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CXR29_RS07630	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CXR29_RS07635	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CXR29_RS07650	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
CXR29_RS07665	COG0183	Belongs to the thiolase family
CXR29_RS07715	COG1946	Acyl-CoA thioesterase
CXR29_RS07735	COG0668	transmembrane transport
CXR29_RS07745	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CXR29_RS07750	COG0698	ribose 5-phosphate isomerase
CXR29_RS07755	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CXR29_RS07805	COG2801	Transposase and inactivated derivatives
CXR29_RS07835	COG0544	peptidyl-prolyl cis-trans isomerase activity
CXR29_RS07845	COG0740	serine-type endopeptidase activity
CXR29_RS07850	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CXR29_RS07855	COG0477	Major facilitator Superfamily
CXR29_RS07865	COG0525	valine-tRNA ligase activity
CXR29_RS07885	COG0285	dihydrofolate synthase activity
CXR29_RS07895	COG0105	UTP biosynthetic process
CXR29_RS07905	COG1530	ribonuclease E activity
CXR29_RS07915	COG1115	amino acid carrier protein
CXR29_RS07925	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CXR29_RS07930	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CXR29_RS07935	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CXR29_RS07940	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CXR29_RS07945	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CXR29_RS07950	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CXR29_RS07960	COG0799	negative regulation of ribosome biogenesis
CXR29_RS07975	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CXR29_RS07975	COG2111	Na H antiporter
CXR29_RS07980	COG1006	Multisubunit Na H antiporter MnhC subunit
CXR29_RS07985	COG0651	ATP synthesis coupled electron transport
CXR29_RS07990	COG1863	multisubunit Na H antiporter MnhE subunit
CXR29_RS08030	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXR29_RS08035	COG3246	L-lysine catabolic process to acetate
CXR29_RS08050	COG2364	Membrane
CXR29_RS08060	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CXR29_RS08105	COG1950	PFAM Membrane protein of
CXR29_RS08115	COG3104	oligopeptide transport
CXR29_RS08240	COG1950	PFAM Membrane protein of
CXR29_RS08250	COG3104	oligopeptide transport
CXR29_RS08260	COG0303	'Molybdopterin
CXR29_RS08275	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CXR29_RS08285	COG0315	cyclic pyranopterin monophosphate synthase activity
CXR29_RS08310	COG0318	PFAM AMP-dependent synthetase and ligase
CXR29_RS08320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CXR29_RS08410	COG0789	Transcriptional regulator
CXR29_RS08450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CXR29_RS08455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CXR29_RS08470	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CXR29_RS08485	COG0537	adenosine 5'-monophosphoramidase activity
CXR29_RS08495	COG0626	cystathionine gamma-synthase activity
CXR29_RS08540	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CXR29_RS08550	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CXR29_RS08570	COG1940	carbohydrate kinase activity
CXR29_RS08580	COG1725	Transcriptional regulator
CXR29_RS08595	COG0174	glutamine synthetase
CXR29_RS08600	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CXR29_RS08625	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CXR29_RS08630	COG0321	lipoyl(octanoyl) transferase activity
CXR29_RS08640	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXR29_RS08645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CXR29_RS08650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CXR29_RS08655	COG0167	dihydroorotate dehydrogenase activity
CXR29_RS08675	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CXR29_RS08680	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CXR29_RS08685	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CXR29_RS08695	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CXR29_RS08700	COG0723	plastoquinol--plastocyanin reductase activity
CXR29_RS08705	COG2010	Cytochrome c
CXR29_RS08710	COG1845	cytochrome c oxidase, subunit III
CXR29_RS08715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CXR29_RS08750	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CXR29_RS08765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXR29_RS08785	COG1528	Iron-storage protein
CXR29_RS08790	COG0154	amidase activity
CXR29_RS08850	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CXR29_RS08875	COG1216	Glycosyl transferase, family 2
CXR29_RS08885	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CXR29_RS08890	COG0653	protein targeting
CXR29_RS08900	COG0805	protein transport
CXR29_RS08905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CXR29_RS08915	COG2378	regulation of single-species biofilm formation
CXR29_RS08940	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CXR29_RS08945	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CXR29_RS08955	COG4122	O-methyltransferase activity
CXR29_RS08965	COG1222	aaa ATPase
CXR29_RS08995	COG0215	cysteine-tRNA ligase activity
CXR29_RS09020	COG0667	Aldo Keto reductase
CXR29_RS09025	COG1968	undecaprenyl-diphosphatase activity
CXR29_RS09045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CXR29_RS09055	COG2030	dehydratase
CXR29_RS09065	COG0183	Belongs to the thiolase family
CXR29_RS09085	COG1960	acyl-CoA dehydrogenase activity
CXR29_RS09090	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CXR29_RS09095	COG2873	o-acetylhomoserine
CXR29_RS09100	COG0587	DNA-directed DNA polymerase activity
CXR29_RS09105	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CXR29_RS09125	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CXR29_RS09130	COG0351	phosphomethylpyrimidine kinase
CXR29_RS09135	COG0254	rRNA binding
CXR29_RS09140	COG0442	prolyl-tRNA aminoacylation
CXR29_RS09155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CXR29_RS09165	COG1119	ATPase activity
CXR29_RS09175	COG0560	Phosphoserine phosphatase
CXR29_RS09210	COG0488	(ABC) transporter
CXR29_RS09215	COG0328	RNA-DNA hybrid ribonuclease activity
CXR29_RS09220	COG2151	metal-sulfur cluster biosynthetic enzyme
CXR29_RS09225	COG0822	iron-sulfur transferase activity
CXR29_RS09235	COG0396	ATPase activity
CXR29_RS09245	COG0719	Fe-S assembly protein
CXR29_RS09280	COG0109	protoheme IX farnesyltransferase activity
CXR29_RS09290	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CXR29_RS09295	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CXR29_RS09300	COG0166	Belongs to the GPI family
CXR29_RS09305	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CXR29_RS09310	COG0149	triose-phosphate isomerase activity
CXR29_RS09315	COG0126	phosphoglycerate kinase activity
CXR29_RS09320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CXR29_RS09325	COG1481	regulation of sporulation
CXR29_RS09335	COG1660	Displays ATPase and GTPase activities
CXR29_RS09340	COG0322	excinuclease ABC activity
CXR29_RS09365	COG0556	nucleotide-excision repair
CXR29_RS09370	COG0237	dephospho-CoA kinase activity
CXR29_RS09370	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CXR29_RS09380	COG0539	negative regulation of cytoplasmic translation
CXR29_RS09385	COG2226	methyltransferase
CXR29_RS09395	COG2050	protein possibly involved in aromatic compounds catabolism
CXR29_RS09415	COG1301	dicarboxylic acid transport
CXR29_RS09420	COG0469	pyruvate kinase activity
CXR29_RS09430	COG0067	glutamate synthase
CXR29_RS09430	COG0069	glutamate synthase activity
CXR29_RS09430	COG0070	glutamate synthase
CXR29_RS09440	COG0159	tryptophan synthase activity
CXR29_RS09445	COG0133	tryptophan synthase activity
CXR29_RS09450	COG0134	indole-3-glycerol-phosphate synthase activity
CXR29_RS09470	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CXR29_RS09475	COG0107	imidazoleglycerol-phosphate synthase activity
CXR29_RS09495	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CXR29_RS09500	COG0140	phosphoribosyl-ATP diphosphatase activity
CXR29_RS09505	COG3201	nicotinamide mononucleotide transporter
CXR29_RS09510	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CXR29_RS09520	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CXR29_RS09530	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CXR29_RS09540	COG1758	RNA polymerase activity
CXR29_RS09545	COG0194	GDP metabolic process
CXR29_RS09550	COG0194	GDP metabolic process
CXR29_RS09555	COG0284	orotidine-5'-phosphate decarboxylase activity
CXR29_RS09560	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CXR29_RS09565	COG0505	Belongs to the CarA family
CXR29_RS09575	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CXR29_RS09580	COG0540	Belongs to the ATCase OTCase family
CXR29_RS09585	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CXR29_RS09590	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CXR29_RS09595	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CXR29_RS09600	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CXR29_RS09605	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CXR29_RS09610	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CXR29_RS09620	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CXR29_RS09625	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CXR29_RS09630	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CXR29_RS09635	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CXR29_RS09640	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CXR29_RS09655	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CXR29_RS09660	COG0124	histidyl-tRNA synthetase
CXR29_RS09665	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CXR29_RS09670	COG1196	nuclear chromosome segregation
CXR29_RS09680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CXR29_RS09685	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CXR29_RS09690	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CXR29_RS09700	COG2255	four-way junction helicase activity
CXR29_RS09705	COG0632	four-way junction helicase activity
CXR29_RS09710	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CXR29_RS09715	COG0217	transcriptional regulatory protein
CXR29_RS09725	COG1506	peptidase
CXR29_RS09725	COG4946	Tricorn protease homolog
CXR29_RS09725	COG0823	Involved in the tonB-independent uptake of proteins
CXR29_RS09735	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CXR29_RS09785	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CXR29_RS09800	COG0484	heat shock protein binding
CXR29_RS09805	COG1420	regulation of RNA biosynthetic process
CXR29_RS09830	COG0481	GTPase activity
CXR29_RS09845	COG0268	Binds directly to 16S ribosomal RNA
CXR29_RS09865	COG1307	EDD domain protein, DegV family
CXR29_RS09870	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CXR29_RS09880	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CXR29_RS09885	COG0495	leucyl-tRNA aminoacylation
CXR29_RS09890	COG1022	Amp-dependent synthetase and ligase
CXR29_RS09895	COG0435	Glutathione S-transferase
CXR29_RS09900	COG1295	ribonuclease BN
CXR29_RS09930	COG0358	DNA primase activity
CXR29_RS09935	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CXR29_RS09945	COG0488	(ABC) transporter
CXR29_RS09960	COG0006	proline dipeptidase activity
CXR29_RS09970	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CXR29_RS09985	COG0423	glycine-tRNA ligase activity
CXR29_RS09995	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CXR29_RS10000	COG1381	Involved in DNA repair and RecF pathway recombination
CXR29_RS10005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CXR29_RS10035	COG3739	integral membrane protein
CXR29_RS10050	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CXR29_RS10055	COG2153	protein acetylation
CXR29_RS10070	COG3253	May function as heme-dependent peroxidase
CXR29_RS10075	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CXR29_RS10080	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CXR29_RS10095	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CXR29_RS10100	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CXR29_RS10110	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CXR29_RS10115	COG0531	amino acid
CXR29_RS10120	COG0569	domain protein
CXR29_RS10140	COG0756	dUTP diphosphatase activity
CXR29_RS10160	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CXR29_RS10170	COG4988	ABC transporter
CXR29_RS10175	COG1294	oxidase, subunit
CXR29_RS10180	COG1271	oxidase subunit
CXR29_RS10195	COG0187	DNA topoisomerase II activity
CXR29_RS10200	COG0860	N-Acetylmuramoyl-L-alanine amidase
CXR29_RS10205	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CXR29_RS10225	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CXR29_RS10230	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CXR29_RS10260	COG1799	cell septum assembly
CXR29_RS10265	COG1496	oxidoreductase activity
CXR29_RS10270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CXR29_RS10280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CXR29_RS10285	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CXR29_RS10295	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CXR29_RS10300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CXR29_RS10305	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CXR29_RS10310	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CXR29_RS10315	COG0768	penicillin binding
CXR29_RS10325	COG0275	rRNA processing
CXR29_RS10330	COG2001	Belongs to the MraZ family
CXR29_RS10335	COG0714	Associated with various cellular activities
CXR29_RS10345	COG1305	Transglutaminase-like
CXR29_RS10360	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CXR29_RS10370	COG0142	geranyltranstransferase activity
CXR29_RS10385	COG0515	serine threonine protein kinase
CXR29_RS10385	COG2815	serine threonine protein kinase
CXR29_RS10390	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CXR29_RS10400	COG1716	ATPase activity
CXR29_RS10405	COG0509	glycine decarboxylation via glycine cleavage system
CXR29_RS10480	COG0076	glutamate decarboxylase activity
CXR29_RS10490	COG1175	transmembrane transport
CXR29_RS10495	COG0395	ABC-type sugar transport system, permease component
CXR29_RS10505	COG0738	Major facilitator superfamily
CXR29_RS10520	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CXR29_RS10540	COG0534	Mate efflux family protein
CXR29_RS10550	COG0183	Belongs to the thiolase family
CXR29_RS10555	COG1028	Short-chain dehydrogenase reductase Sdr
CXR29_RS10565	COG0559	Belongs to the binding-protein-dependent transport system permease family
CXR29_RS10570	COG4177	L-phenylalanine transmembrane transporter activity
CXR29_RS10580	COG1120	ATPase activity
CXR29_RS10590	COG2801	Transposase and inactivated derivatives
CXR29_RS10630	COG0009	L-threonylcarbamoyladenylate synthase
CXR29_RS10635	COG0628	permease
CXR29_RS10640	COG1160	GTP binding
CXR29_RS10645	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CXR29_RS10660	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CXR29_RS10680	COG0494	nUDIX hydrolase
CXR29_RS10685	COG0504	CTP synthase activity
CXR29_RS10700	COG0728	peptidoglycan biosynthetic process
CXR29_RS10720	COG0497	DNA recombination
CXR29_RS10725	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CXR29_RS10740	COG0647	UMP catabolic process
CXR29_RS10755	COG1012	belongs to the aldehyde dehydrogenase family
CXR29_RS10765	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CXR29_RS10805	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CXR29_RS10810	COG3284	Transcriptional regulator
CXR29_RS10820	COG1012	belongs to the aldehyde dehydrogenase family
CXR29_RS10825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CXR29_RS10835	COG0165	Argininosuccinate lyase
CXR29_RS10840	COG1438	arginine binding
CXR29_RS10845	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CXR29_RS10850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CXR29_RS10855	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CXR29_RS10860	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CXR29_RS10865	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CXR29_RS10905	COG1484	DNA-dependent DNA replication
CXR29_RS10910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CXR29_RS10915	COG1061	Type III restriction enzyme res subunit
CXR29_RS10940	COG1074	ATP-dependent DNA helicase activity
CXR29_RS10960	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CXR29_RS10970	COG4691	Plasmid stability protein
CXR29_RS11005	COG1794	racemase activity, acting on amino acids and derivatives
CXR29_RS11035	COG0477	Major facilitator Superfamily
CXR29_RS11060	COG0072	phenylalanine-tRNA ligase activity
CXR29_RS11060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CXR29_RS11065	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CXR29_RS11100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CXR29_RS11105	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CXR29_RS11110	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CXR29_RS11115	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CXR29_RS11140	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CXR29_RS11145	COG1473	amidohydrolase
CXR29_RS11155	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CXR29_RS11160	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CXR29_RS11170	COG0131	Imidazoleglycerol-phosphate dehydratase
CXR29_RS11175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CXR29_RS11185	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CXR29_RS11195	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CXR29_RS11205	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CXR29_RS11210	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CXR29_RS11220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CXR29_RS11225	COG2137	regulation of response to DNA damage stimulus
CXR29_RS11230	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CXR29_RS11245	COG1396	sequence-specific DNA binding
CXR29_RS11250	COG1058	Belongs to the CinA family
CXR29_RS11250	COG1546	Belongs to the CinA family
CXR29_RS11260	COG1674	ftsk spoiiie
CXR29_RS11285	COG4565	transcriptional regulatory protein
CXR29_RS11295	COG2851	Citrate transporter
CXR29_RS11310	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CXR29_RS11315	COG1620	l-lactate permease
CXR29_RS11320	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CXR29_RS11325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXR29_RS11330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CXR29_RS11340	COG1902	pentaerythritol trinitrate reductase activity
CXR29_RS11340	COG0446	pyridine nucleotide-disulphide oxidoreductase
CXR29_RS11360	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CXR29_RS11370	COG1960	acyl-CoA dehydrogenase activity
CXR29_RS11385	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CXR29_RS11395	COG0612	Peptidase, M16
CXR29_RS11400	COG1185	polyribonucleotide nucleotidyltransferase activity
CXR29_RS11405	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CXR29_RS11425	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CXR29_RS11435	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CXR29_RS11440	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CXR29_RS11455	COG0779	Required for maturation of 30S ribosomal subunits
CXR29_RS11475	COG0442	prolyl-tRNA aminoacylation
CXR29_RS11495	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CXR29_RS11500	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CXR29_RS11505	COG0750	zinc metalloprotease
CXR29_RS11510	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CXR29_RS11515	COG1960	acyl-CoA dehydrogenase activity
CXR29_RS11520	COG2890	protein-(glutamine-N5) methyltransferase activity
CXR29_RS11535	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CXR29_RS11540	COG0575	Belongs to the CDS family
CXR29_RS11545	COG0233	cytoplasmic translational termination
CXR29_RS11550	COG0528	UMP kinase activity
CXR29_RS11555	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CXR29_RS11560	COG0052	Belongs to the universal ribosomal protein uS2 family
CXR29_RS11570	COG4974	Belongs to the 'phage' integrase family
CXR29_RS11585	COG0792	nuclease activity
CXR29_RS11595	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CXR29_RS11605	COG0681	Belongs to the peptidase S26 family
CXR29_RS11615	COG0336	Belongs to the RNA methyltransferase TrmD family
CXR29_RS11620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CXR29_RS11625	COG1837	Belongs to the UPF0109 family
CXR29_RS11630	COG0228	four-way junction DNA binding
CXR29_RS11670	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CXR29_RS11675	COG0571	ribonuclease III activity
CXR29_RS11680	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CXR29_RS11705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXR29_RS11710	COG0765	amino acid transport
CXR29_RS11715	COG0765	amino acid transport
CXR29_RS11720	COG1126	abc transporter atp-binding protein
CXR29_RS11725	COG0742	ribosomal rna small subunit methyltransferase
CXR29_RS11735	COG1461	Dihydroxyacetone kinase
CXR29_RS11740	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CXR29_RS11750	COG1181	Belongs to the D-alanine--D-alanine ligase family
CXR29_RS11760	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CXR29_RS11770	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CXR29_RS11775	COG0066	3-isopropylmalate dehydratase activity
CXR29_RS11780	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CXR29_RS11785	COG1414	Transcriptional regulator
CXR29_RS11790	COG1349	DNA-binding transcription factor activity
CXR29_RS11810	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CXR29_RS11815	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CXR29_RS11825	COG2017	converts alpha-aldose to the beta-anomer
CXR29_RS11850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CXR29_RS11860	COG1643	Atp-dependent helicase
CXR29_RS11890	COG3340	Belongs to the peptidase S51 family
CXR29_RS11900	COG1505	serine-type exopeptidase activity
CXR29_RS11915	COG0477	Major facilitator Superfamily
CXR29_RS11920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CXR29_RS11925	COG0473	3-isopropylmalate dehydrogenase activity
CXR29_RS11940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CXR29_RS11945	COG4552	Acetyltransferase involved in intracellular survival and related
CXR29_RS11950	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CXR29_RS11955	COG0440	acetolactate synthase activity
CXR29_RS11960	COG0028	Belongs to the TPP enzyme family
CXR29_RS11965	COG1132	(ABC) transporter
CXR29_RS11970	COG1132	(ABC) transporter
CXR29_RS11975	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CXR29_RS11980	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CXR29_RS12030	COG0129	dihydroxy-acid dehydratase activity
CXR29_RS12035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CXR29_RS12050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CXR29_RS12055	COG1045	serine acetyltransferase
CXR29_RS12065	COG0242	peptide deformylase activity
CXR29_RS12075	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CXR29_RS12080	COG0154	amidase activity
CXR29_RS12085	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CXR29_RS12095	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CXR29_RS12110	COG0482	sulfurtransferase activity
CXR29_RS12160	COG0659	secondary active sulfate transmembrane transporter activity
CXR29_RS12170	COG0247	lactate metabolic process
CXR29_RS12175	COG1139	Iron-sulfur cluster binding protein
CXR29_RS12180	COG1556	Lactate utilization protein
CXR29_RS12190	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CXR29_RS12205	COG2066	Belongs to the glutaminase family
CXR29_RS12220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXR29_RS12225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CXR29_RS12270	COG1914	H( )-stimulated, divalent metal cation uptake system
CXR29_RS12275	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CXR29_RS12280	COG4336	lyase activity
CXR29_RS12285	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CXR29_RS12290	COG4770	biotin carboxylase activity
CXR29_RS12335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CXR29_RS12340	COG0531	amino acid
CXR29_RS12360	COG2813	Specifically methylates the guanine in position
CXR29_RS12365	COG0589	response to stress
CXR29_RS12370	COG2207	Transcriptional regulator
CXR29_RS12395	COG0045	succinate-CoA ligase (ADP-forming) activity
CXR29_RS12400	COG1846	Transcriptional regulator
CXR29_RS12430	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CXR29_RS12440	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CXR29_RS12440	COG1473	amidohydrolase
CXR29_RS12445	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CXR29_RS12445	COG0662	Cupin 2, conserved barrel domain protein
CXR29_RS12450	COG2009	succinate dehydrogenase
CXR29_RS12470	COG1686	Belongs to the peptidase S11 family
CXR29_RS12480	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CXR29_RS12495	COG0714	Associated with various cellular activities
CXR29_RS12525	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CXR29_RS12570	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CXR29_RS12585	COG2884	Cell division ATP-binding protein ftsE
CXR29_RS12590	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CXR29_RS12650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CXR29_RS12670	COG1079	Belongs to the binding-protein-dependent transport system permease family
CXR29_RS12675	COG4603	Belongs to the binding-protein-dependent transport system permease family
CXR29_RS12680	COG3845	ABC transporter
CXR29_RS12685	COG1744	ABC transporter substrate-binding protein PnrA-like
CXR29_RS12690	COG0488	(ABC) transporter
CXR29_RS12700	COG3594	Acyltransferase
CXR29_RS12705	COG1410	methionine synthase
CXR29_RS12705	COG0646	methionine synthase
CXR29_RS12710	COG0477	Major facilitator Superfamily
CXR29_RS12715	COG0318	PFAM AMP-dependent synthetase and ligase
CXR29_RS12720	COG3835	regulator
CXR29_RS12730	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CXR29_RS12735	COG3265	gluconokinase activity
CXR29_RS12750	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CXR29_RS12755	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CXR29_RS12775	COG1472	Belongs to the glycosyl hydrolase 3 family
CXR29_RS12785	COG0395	ABC-type sugar transport system, permease component
CXR29_RS12805	COG1070	Carbohydrate kinase
CXR29_RS12810	COG3842	ATPase activity
CXR29_RS12815	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CXR29_RS12825	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CXR29_RS12835	COG0667	Aldo Keto reductase
CXR29_RS12845	COG0456	acetyltransferase
CXR29_RS12845	COG1214	PFAM Peptidase M22, glycoprotease
CXR29_RS12850	COG0802	atpase or kinase
CXR29_RS12855	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CXR29_RS12870	COG0736	holo-[acyl-carrier-protein] synthase activity
CXR29_RS12875	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CXR29_RS12880	COG1072	(Pantothenic acid kinase))
CXR29_RS12885	COG1132	(ABC) transporter
CXR29_RS12890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CXR29_RS12895	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CXR29_RS12900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CXR29_RS12915	COG0737	Belongs to the 5'-nucleotidase family
CXR29_RS12915	COG1525	nuclease
CXR29_RS12915	COG4085	toxin activity
CXR29_RS12920	COG0101	tRNA pseudouridine synthase activity
CXR29_RS12930	COG0438	transferase activity, transferring glycosyl groups
CXR29_RS12950	COG1122	ATPase activity
CXR29_RS12955	COG1268	BioY protein
CXR29_RS12960	COG0519	Catalyzes the synthesis of GMP from XMP
CXR29_RS12960	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CXR29_RS12975	COG0516	GMP reductase activity
CXR29_RS12980	COG0583	DNA-binding transcription factor activity
CXR29_RS12990	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CXR29_RS12995	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CXR29_RS13000	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CXR29_RS13005	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CXR29_RS13010	COG0157	Belongs to the NadC ModD family
CXR29_RS13035	COG0351	phosphomethylpyrimidine kinase
CXR29_RS13040	COG0352	thiamine-phosphate diphosphorylase activity
CXR29_RS13045	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CXR29_RS13050	COG4214	carbohydrate transport
CXR29_RS13055	COG1129	ABC transporter
CXR29_RS13060	COG4213	ABC transporter substrate-binding protein
CXR29_RS13065	COG1609	Transcriptional regulator
CXR29_RS13090	COG0564	pseudouridine synthase activity
CXR29_RS13100	COG1960	acyl-CoA dehydrogenase activity
CXR29_RS13115	COG0577	efflux transmembrane transporter activity
CXR29_RS13120	COG1136	(ABC) transporter
CXR29_RS13130	COG0459	protein refolding
CXR29_RS13135	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CXR29_RS13140	COG3583	domain protein
CXR29_RS13145	COG0084	hydrolase, TatD family'
CXR29_RS13195	COG2089	acid synthase
CXR29_RS13200	COG1216	Glycosyl transferase, family 2
CXR29_RS13240	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CXR29_RS13245	COG2011	ABC-type metal ion transport system permease component
CXR29_RS13250	COG1464	Belongs to the NlpA lipoprotein family
CXR29_RS13260	COG4585	Histidine kinase
CXR29_RS13265	COG2197	response regulator
CXR29_RS13270	COG1028	Short-chain dehydrogenase reductase Sdr
CXR29_RS13295	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CXR29_RS13330	COG0579	oxidoreductase
CXR29_RS13350	COG0028	Belongs to the TPP enzyme family
CXR29_RS13395	COG0415	Belongs to the DNA photolyase family
CXR29_RS13405	COG0702	epimerase
CXR29_RS13450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXR29_RS13455	COG0601	transmembrane transport
CXR29_RS13460	COG0747	negative chemotaxis
CXR29_RS13510	COG1215	transferase activity, transferring glycosyl groups
CXR29_RS13535	COG0438	transferase activity, transferring glycosyl groups
CXR29_RS13545	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CXR29_RS13545	COG2755	lipolytic protein G-D-S-L family
CXR29_RS13560	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CXR29_RS13585	COG0667	Aldo Keto reductase
CXR29_RS13590	COG1301	dicarboxylic acid transport
CXR29_RS13595	COG0598	Magnesium transport protein CorA
CXR29_RS13600	COG0438	transferase activity, transferring glycosyl groups
CXR29_RS13635	COG1793	dna ligase
CXR29_RS13635	COG3285	dna ligase
CXR29_RS13640	COG2080	2 iron, 2 sulfur cluster binding
CXR29_RS13645	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CXR29_RS13650	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CXR29_RS13710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXR29_RS13715	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CXR29_RS13725	COG1028	Short-chain dehydrogenase reductase Sdr
CXR29_RS13790	COG2814	Major facilitator Superfamily
CXR29_RS13835	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CXR29_RS13835	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CXR29_RS13845	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CXR29_RS13845	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CXR29_RS13900	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CXR29_RS13905	COG0521	Mo-molybdopterin cofactor biosynthetic process
CXR29_RS13920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CXR29_RS13925	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CXR29_RS13930	COG0387	Pfam Sodium calcium exchanger
CXR29_RS13960	COG3328	transposase activity
CXR29_RS13965	COG0318	PFAM AMP-dependent synthetase and ligase
CXR29_RS14000	COG0667	Aldo Keto reductase
CXR29_RS14005	COG2814	Major facilitator Superfamily
CXR29_RS14025	COG2818	Glycosylase
CXR29_RS14030	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CXR29_RS14035	COG2031	fatty acid transporter
CXR29_RS14040	COG1012	belongs to the aldehyde dehydrogenase family
CXR29_RS14055	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXR29_RS14095	COG2855	membrane
CXR29_RS14125	COG0477	Major facilitator Superfamily
CXR29_RS14165	COG1970	mechanosensitive ion channel activity
CXR29_RS14255	COG0791	NLP P60 protein
CXR29_RS14255	COG1388	LysM domain
CXR29_RS14255	COG3103	Sh3 type 3 domain protein
CXR29_RS14265	COG1012	belongs to the aldehyde dehydrogenase family
CXR29_RS14270	COG0259	pyridoxamine-phosphate oxidase activity
CXR29_RS14275	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CXR29_RS14280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXR29_RS14300	COG1278	Cold shock
CXR29_RS14335	COG0745	RESPONSE REGULATOR receiver
CXR29_RS14340	COG2205	protein histidine kinase activity
CXR29_RS14345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CXR29_RS14365	COG0501	Belongs to the peptidase M48B family
CXR29_RS14375	COG2501	S4 domain
CXR29_RS14400	COG0459	protein refolding
CXR29_RS14405	COG1278	Cold shock
CXR29_RS14425	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CXR29_RS14435	COG1228	amidohydrolase
CXR29_RS14450	COG3483	tryptophan 2,3-dioxygenase activity
CXR29_RS14470	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CXR29_RS14490	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CXR29_RS14505	COG1609	Transcriptional regulator
CXR29_RS14510	COG3842	ATPase activity
CXR29_RS14520	COG1028	Short-chain dehydrogenase reductase Sdr
CXR29_RS14525	COG0531	amino acid
CXR29_RS14535	COG0215	cysteine-tRNA ligase activity
CXR29_RS14540	COG0733	neurotransmitter:sodium symporter activity
CXR29_RS14560	COG1113	amino acid transport
CXR29_RS14570	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CXR29_RS14590	COG0745	RESPONSE REGULATOR receiver
CXR29_RS14605	COG0588	phosphoglycerate mutase activity
CXR29_RS14610	COG0385	Bile acid
CXR29_RS14625	COG0297	glycogen (starch) synthase activity
CXR29_RS14675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CXR29_RS14695	COG0589	response to stress
CXR29_RS14710	COG0519	Catalyzes the synthesis of GMP from XMP
CXR29_RS14710	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CXR29_RS14735	COG1619	proteins homologs of microcin C7 resistance protein MccF
CXR29_RS14755	COG0019	diaminopimelate decarboxylase activity
CXR29_RS14760	COG3835	regulator
CXR29_RS14765	COG2197	response regulator
CXR29_RS14785	COG4044	May play a role in the intracellular transport of hydrophobic ligands
CXR29_RS14795	COG0745	RESPONSE REGULATOR receiver
CXR29_RS14800	COG0456	acetyltransferase
CXR29_RS14800	COG0454	-acetyltransferase
CXR29_RS14805	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CXR29_RS14830	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CXR29_RS14850	COG0306	phosphate transporter
CXR29_RS14890	COG0667	Aldo Keto reductase
CXR29_RS14915	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CXR29_RS14920	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CXR29_RS14925	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CXR29_RS14930	COG2188	Transcriptional regulator
CXR29_RS14935	COG2154	pterin-4-alpha-carbinolamine dehydratase
CXR29_RS14940	COG0667	Aldo Keto reductase
CXR29_RS14955	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CXR29_RS14960	COG1132	(ABC) transporter
CXR29_RS14970	COG0438	transferase activity, transferring glycosyl groups
CXR29_RS14985	COG2205	protein histidine kinase activity
CXR29_RS15000	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CXR29_RS15020	COG1082	Xylose isomerase domain protein TIM barrel
CXR29_RS15020	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CXR29_RS15065	COG2197	response regulator
CXR29_RS15070	COG4585	Histidine kinase
CXR29_RS15075	COG2409	Drug exporters of the RND superfamily
CXR29_RS15080	COG1335	isochorismatase
CXR29_RS15095	COG0531	amino acid
CXR29_RS15110	COG0137	argininosuccinate synthase activity
CXR29_RS15125	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CXR29_RS15175	COG1316	TRANSCRIPTIONal
CXR29_RS15190	COG2409	Drug exporters of the RND superfamily
CXR29_RS15195	COG1309	transcriptional regulator
CXR29_RS15215	COG0531	amino acid
CXR29_RS15235	COG1966	Carbon starvation protein
CXR29_RS15240	COG0604	alcohol dehydrogenase
CXR29_RS15255	COG0561	phosphatase activity
CXR29_RS15260	COG0561	phosphatase activity
CXR29_RS15265	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CXR29_RS15270	COG1597	lipid kinase activity
CXR29_RS15290	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CXR29_RS15295	COG0829	nickel cation binding
CXR29_RS15300	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CXR29_RS15310	COG0804	urea catabolic process
CXR29_RS15315	COG0832	Belongs to the urease beta subunit family
CXR29_RS15320	COG0831	urea catabolic process
CXR29_RS15335	COG0789	Transcriptional regulator
CXR29_RS15340	COG0484	heat shock protein binding
CXR29_RS15345	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CXR29_RS15350	COG0443	Heat shock 70 kDa protein
CXR29_RS15355	COG0659	secondary active sulfate transmembrane transporter activity
CXR29_RS15360	COG0789	Transcriptional regulator
CXR29_RS15365	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CXR29_RS15370	COG4592	Periplasmic binding protein
CXR29_RS15380	COG1620	l-lactate permease
CXR29_RS15385	COG2186	Transcriptional regulator
CXR29_RS15390	COG0523	cobalamin synthesis protein
CXR29_RS15415	COG0154	amidase activity
CXR29_RS15435	COG0514	ATP-dependent DNA helicase (RecQ)
CXR29_RS15450	COG0583	DNA-binding transcription factor activity
CXR29_RS15460	COG1162	GTPase activity
CXR29_RS15470	COG4107	phosphonate C-P lyase system protein PhnK
CXR29_RS15485	COG3152	Membrane
CXR29_RS15490	COG2814	Major facilitator Superfamily
CXR29_RS15510	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CXR29_RS15510	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CXR29_RS15515	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CXR29_RS15520	COG0028	Belongs to the TPP enzyme family
CXR29_RS15555	COG2315	Protein conserved in bacteria
CXR29_RS15560	COG0252	asparaginase activity
CXR29_RS15565	COG2130	NADP-dependent
CXR29_RS15580	COG2323	membrane
CXR29_RS15590	COG2197	response regulator
CXR29_RS15595	COG4585	Histidine kinase
CXR29_RS15635	COG2197	response regulator
CXR29_RS15645	COG0431	NADPH-dependent FMN reductase
CXR29_RS15650	COG3226	Transcriptional regulator
CXR29_RS15665	COG0601	transmembrane transport
CXR29_RS15675	COG1115	amino acid carrier protein
CXR29_RS15695	COG1960	acyl-CoA dehydrogenase activity
CXR29_RS15700	COG1960	acyl-CoA dehydrogenase activity
CXR29_RS15715	COG3842	ATPase activity
CXR29_RS15720	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CXR29_RS15735	COG4221	oxidoreductase activity
CXR29_RS15770	COG3573	Dehydrogenase
CXR29_RS15795	COG0542	response to heat
CXR29_RS15810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXR29_RS15815	COG2957	Belongs to the agmatine deiminase family
CXR29_RS15825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXR29_RS15835	COG1024	Enoyl-CoA hydratase
CXR29_RS15840	COG2814	Major facilitator Superfamily
CXR29_RS15850	COG0069	glutamate synthase activity
CXR29_RS15865	COG1028	Short-chain dehydrogenase reductase Sdr
CXR29_RS15875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CXR29_RS15880	COG0318	PFAM AMP-dependent synthetase and ligase
CXR29_RS15885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CXR29_RS15905	COG1120	ATPase activity
CXR29_RS15910	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXR29_RS15915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXR29_RS15920	COG4592	Periplasmic binding protein
CXR29_RS15925	COG2207	Transcriptional regulator
CXR29_RS15995	COG0436	Aminotransferase
CXR29_RS16025	COG4948	Mandelate Racemase Muconate Lactonizing
CXR29_RS16045	COG2234	aminopeptidase activity
CXR29_RS16075	COG2267	carboxylic ester hydrolase activity
CXR29_RS16080	COG3448	diguanylate cyclase activity
CXR29_RS16080	COG4175	Glycine betaine
CXR29_RS16085	COG4176	ABC-type proline glycine betaine transport system permease component
CXR29_RS16095	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CXR29_RS16095	COG2169	Transcriptional regulator
CXR29_RS16105	COG3547	Transposase (IS116 IS110 IS902 family)
CXR29_RS16110	COG2801	Transposase and inactivated derivatives
CXR29_RS16140	COG3547	Transposase (IS116 IS110 IS902 family)
CXR29_RS16150	COG2801	Transposase and inactivated derivatives
CXR29_RS16210	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CXR29_RS16215	COG0823	Involved in the tonB-independent uptake of proteins
CXR29_RS16215	COG1506	peptidase
CXR29_RS16230	COG0745	RESPONSE REGULATOR receiver
CXR29_RS16235	COG1320	monovalent cation:proton antiporter activity
CXR29_RS16250	COG0651	ATP synthesis coupled electron transport
CXR29_RS16255	COG1006	Multisubunit Na H antiporter MnhC subunit
CXR29_RS16260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CXR29_RS16260	COG2111	Na H antiporter
CXR29_RS16270	COG0717	Belongs to the dCTP deaminase family
CXR29_RS16310	COG1028	Short-chain dehydrogenase reductase Sdr
CXR29_RS16325	COG0776	regulation of translation
CXR29_RS16330	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CXR29_RS16335	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CXR29_RS16340	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CXR29_RS16350	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXR29_RS16355	COG0022	dehydrogenase e1 component
CXR29_RS16390	COG0477	Major facilitator Superfamily
CXR29_RS16410	COG1012	belongs to the aldehyde dehydrogenase family
CXR29_RS16425	COG3290	protein histidine kinase activity
CXR29_RS16435	COG1937	Protein conserved in bacteria
CXR29_RS16460	COG0745	RESPONSE REGULATOR receiver
CXR29_RS16465	COG2205	protein histidine kinase activity
CXR29_RS16485	COG3387	PFAM Glycoside hydrolase 15-related
CXR29_RS16520	COG0514	ATP-dependent DNA helicase (RecQ)
CXR29_RS16535	COG2801	Transposase and inactivated derivatives
CXR29_RS16550	COG2814	Major facilitator Superfamily
CXR29_RS16565	COG2326	polyphosphate kinase activity
CXR29_RS16575	COG2860	membrane
CXR29_RS16580	COG1764	response to oxidative stress
CXR29_RS16605	COG2226	methyltransferase
CXR29_RS16610	COG3851	Histidine kinase
CXR29_RS16615	COG2197	response regulator
CXR29_RS16625	COG3764	Sortase (surface protein transpeptidase)
CXR29_RS16640	COG4152	abc transporter atp-binding protein
CXR29_RS16650	COG2197	response regulator
CXR29_RS16665	COG1131	(ABC) transporter
CXR29_RS16670	COG1785	Belongs to the alkaline phosphatase family
CXR29_RS16700	COG3835	regulator
CXR29_RS16725	COG0583	DNA-binding transcription factor activity
CXR29_RS16730	COG1982	Orn Lys Arg decarboxylase major
CXR29_RS16740	COG0583	DNA-binding transcription factor activity
CXR29_RS16750	COG0531	amino acid
CXR29_RS16790	COG0277	FAD linked oxidase domain protein
CXR29_RS16810	COG0477	Major facilitator Superfamily
CXR29_RS16820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CXR29_RS16865	COG1012	belongs to the aldehyde dehydrogenase family
CXR29_RS16875	COG1921	L-seryl-tRNASec selenium transferase activity
CXR29_RS16885	COG0709	Synthesizes selenophosphate from selenide and ATP
CXR29_RS16905	COG0437	4 iron, 4 sulfur cluster binding
CXR29_RS16910	COG3383	formate dehydrogenase (NAD+) activity
CXR29_RS16910	COG0243	molybdopterin cofactor binding
CXR29_RS16915	COG0243	molybdopterin cofactor binding
CXR29_RS16915	COG3383	formate dehydrogenase (NAD+) activity
CXR29_RS16925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CXR29_RS16930	COG1316	TRANSCRIPTIONal
CXR29_RS16935	COG1278	Cold shock
CXR29_RS16945	COG1011	Hydrolase
CXR29_RS16955	COG1607	acyl-coa hydrolase
CXR29_RS16995	COG0305	Participates in initiation and elongation during chromosome replication
CXR29_RS17010	COG1136	(ABC) transporter
CXR29_RS17015	COG2733	membrane
CXR29_RS17025	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CXR29_RS17045	COG0359	binds to the 23S rRNA
CXR29_RS17050	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CXR29_RS17060	COG0360	Binds together with S18 to 16S ribosomal RNA
CXR29_RS17070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CXR29_RS17075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CXR29_RS17085	COG0617	tRNA 3'-terminal CCA addition
CXR29_RS17110	COG0492	ferredoxin-NADP+ reductase activity
CXR29_RS17115	COG3118	belongs to the thioredoxin family
CXR29_RS17120	COG3409	Peptidoglycan-binding domain 1 protein
CXR29_RS17120	COG0860	N-Acetylmuramoyl-L-alanine amidase
CXR29_RS17130	COG1192	Involved in chromosome partitioning
CXR29_RS17135	COG0357	Ribosomal RNA small subunit methyltransferase G
CXR29_RS17145	COG0706	membrane insertase activity
CXR29_RS17150	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CXR29_RS17155	COG0594	ribonuclease P activity
CXR29_RS17160	COG0230	Belongs to the bacterial ribosomal protein bL34 family