locus-tag	class	description
EW640_RS00015	ENOG4105D22	carbon starvation protein
EW640_RS00020	ENOG4105C31	Tryptophanyl-tRNA synthetase
EW640_RS00045	ENOG4105E33	succinate dehydrogenase
EW640_RS00070	ENOG4107RM1	amidohydrolase
EW640_RS00080	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
EW640_RS00100	ENOG4105GVJ	transcriptional regulator
EW640_RS00105	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
EW640_RS00120	ENOG4105SHT	UspA domain-containing protein
EW640_RS00125	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
EW640_RS00160	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
EW640_RS00220	ENOG4105CJW	magnesium transporter
EW640_RS00230	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
EW640_RS00265	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
EW640_RS00285	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
EW640_RS00315	ENOG41081AP	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
EW640_RS00320	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
EW640_RS00325	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
EW640_RS00335	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
EW640_RS00345	ENOG4105D7W	serine acetyltransferase
EW640_RS00365	ENOG4105C01	Dihydroxy-acid dehydratase
EW640_RS00395	ENOG4105BZ1	(ABC) transporter
EW640_RS00400	ENOG4105BZ1	(ABC) transporter
EW640_RS00425	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
EW640_RS00430	ENOG4105HHS	UPF0256 protein
EW640_RS00435	ENOG4108JQ1	Dehydrogenase
EW640_RS00445	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
EW640_RS00450	ENOG4105CM2	brancheD-chain amino acid aminotransferase
EW640_RS00455	ENOG41079KZ	Major Facilitator Superfamily
EW640_RS00460	ENOG4107S5Z	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity)
EW640_RS00485	ENOG4105CQ7	ATP-dependent helicase
EW640_RS00500	ENOG4105C5B	carbamate kinase
EW640_RS00510	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
EW640_RS00525	ENOG4107REC	cytoplasmic protein
EW640_RS00530	ENOG4105G5A	Protein of unknown function (DUF2877)
EW640_RS00540	ENOG4105C2W	permease
EW640_RS00570	ENOG4105ERH	Fumarylacetoacetate hydrolase
EW640_RS00575	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
EW640_RS00610	ENOG41069M3	Transcriptional regulator
EW640_RS00615	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
EW640_RS00620	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
EW640_RS00625	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
EW640_RS00635	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
EW640_RS00645	ENOG4105CPF	Cell wall formation (By similarity)
EW640_RS00660	ENOG4105DP4	dak2 domain fusion protein ylov
EW640_RS00670	ENOG4106H78	methyltransferase
EW640_RS00680	ENOG4105E5Q	amino acid AbC transporter
EW640_RS00685	ENOG4105E5Q	amino acid AbC transporter
EW640_RS00695	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
EW640_RS00705	ENOG41063DX	50S ribosomal protein L32
EW640_RS00710	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
EW640_RS00720	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
EW640_RS00725	ENOG4105J5T	Amp-dependent synthetase and ligase
EW640_RS00730	ENOG4105CRW	Short chain fatty acid transporter
EW640_RS00740	ENOG4105KRQ	Addiction module toxin, Txe YoeB family
EW640_RS00750	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
EW640_RS00760	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
EW640_RS00770	ENOG4105K5M	30s ribosomal protein S16
EW640_RS00775	ENOG41082KU	UPF0109 protein
EW640_RS00785	ENOG4107XUM	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
EW640_RS00790	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
EW640_RS00795	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
EW640_RS00810	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
EW640_RS00820	ENOG4107RDP	Dehydrogenase
EW640_RS00835	ENOG41080R2	UPF0102 protein
EW640_RS00855	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
EW640_RS00870	ENOG4105CE9	30S ribosomal protein S2
EW640_RS00875	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
EW640_RS00880	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
EW640_RS00885	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
EW640_RS00890	ENOG4105KNE	Phosphatidate cytidylyltransferase
EW640_RS00895	ENOG4105CQB	FAD linked oxidase domain protein
EW640_RS00910	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
EW640_RS00930	ENOG4105C1G	acyl-Coa dehydrogenase
EW640_RS00935	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
EW640_RS00940	ENOG4105DZP	Membrane-associated zinc metalloprotease
EW640_RS00950	ENOG4105H1G	trap transporter solute receptor taxi family
EW640_RS00960	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
EW640_RS00975	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
EW640_RS00980	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
EW640_RS00985	ENOG4105FBW	Monooxygenase
EW640_RS01015	ENOG4107Z1I	Required for maturation of 30S ribosomal subunits (By similarity)
EW640_RS01030	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
EW640_RS01035	ENOG4107ZPY	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
EW640_RS01050	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
EW640_RS01060	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
EW640_RS01065	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
EW640_RS01070	ENOG4105C1V	Peptidase, M16
EW640_RS01090	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
EW640_RS01110	ENOG4105CN5	Metallo-Beta-Lactamase
EW640_RS01120	ENOG4105DG4	malate L-lactate dehydrogenase
EW640_RS01130	ENOG4105CEV	competence damage-inducible protein
EW640_RS01135	ENOG4105WBV	Transcriptional regulator
EW640_RS01145	ENOG410849A	acetyltransferase, (GNAT) family
EW640_RS01150	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
EW640_RS01155	ENOG4105KC9	Modulates RecA activity (By similarity)
EW640_RS01165	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
EW640_RS01170	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
EW640_RS01175	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
EW640_RS01185	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
EW640_RS01195	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
EW640_RS01205	ENOG4105CIH	Imidazole acetol-phosphate transaminase
EW640_RS01210	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
EW640_RS01220	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
EW640_RS01225	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
EW640_RS01240	ENOG4105CH6	catalase
EW640_RS01250	ENOG4105CFC	Transporter
EW640_RS01265	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
EW640_RS01270	ENOG41084BS	50S ribosomal protein L35
EW640_RS01275	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
EW640_RS01280	ENOG4108RWN	rrna methyltransferase
EW640_RS01285	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
EW640_RS01290	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
EW640_RS01295	ENOG41080V3	Major Facilitator superfamily
EW640_RS01305	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
EW640_RS01310	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
EW640_RS01315	ENOG4105CHR	reductase
EW640_RS01325	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
EW640_RS01335	ENOG4105D3Q	Sugar transferase
EW640_RS01350	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
EW640_RS01365	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
EW640_RS01370	ENOG4107W19	lmbE family
EW640_RS01380	ENOG4108RJ9	Glycosyl transferase, family 2
EW640_RS01390	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
EW640_RS01395	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
EW640_RS01400	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
EW640_RS01405	ENOG4105CAS	nag kinase
EW640_RS01415	ENOG4105DBV	ornithine carbamoyltransferase
EW640_RS01420	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
EW640_RS01425	ENOG4105CDH	Citrulline--aspartate ligase
EW640_RS01430	ENOG4105CH7	arginosuccinase
EW640_RS01440	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
EW640_RS01475	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
EW640_RS01495	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
EW640_RS01510	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
EW640_RS01550	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
EW640_RS01570	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
EW640_RS01575	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
EW640_RS01590	ENOG4105CAT	Cytidine monophosphate kinase
EW640_RS01595	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
EW640_RS01600	ENOG4105DSF	transport protein
EW640_RS01610	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
EW640_RS01620	ENOG4105CEY	Amp-dependent synthetase and ligase
EW640_RS01625	ENOG4105CHR	reductase
EW640_RS01635	ENOG4105CHR	reductase
EW640_RS01640	ENOG4105D2B	acyl-CoA dehydrogenase
EW640_RS01645	ENOG4105D2B	acyl-CoA dehydrogenase
EW640_RS01650	ENOG4105CHU	acetyl-coa acetyltransferase
EW640_RS01655	ENOG4105CEY	Amp-dependent synthetase and ligase
EW640_RS01660	ENOG4105UQX	Mate efflux family protein
EW640_RS01695	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
EW640_RS01715	ENOG4108RWP	Major Facilitator Superfamily protein
EW640_RS01745	ENOG4105CPF	Cell wall formation (By similarity)
EW640_RS01750	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
EW640_RS01785	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
EW640_RS01855	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
EW640_RS01870	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
EW640_RS01885	ENOG4105E9H	Lytic Murein transglycosylase
EW640_RS01925	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
EW640_RS01930	ENOG4108V6E	Cell division protein mraZ
EW640_RS01935	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
EW640_RS01945	ENOG4105CJN	penicillin-binding protein
EW640_RS01950	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
EW640_RS01960	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
EW640_RS01965	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
EW640_RS01975	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
EW640_RS01980	ENOG4105DFU	Cell wall formation (By similarity)
EW640_RS01990	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
EW640_RS01995	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
EW640_RS02000	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
EW640_RS02025	ENOG4105C0B	DNA polymerase III (alpha subunit)
EW640_RS02030	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
EW640_RS02035	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
EW640_RS02055	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
EW640_RS02060	ENOG4108RU2	n-acetylmuramoyl-l-alanine amidase
EW640_RS02065	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
EW640_RS02085	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
EW640_RS02090	ENOG4108JJ9	ABC, transporter
EW640_RS02100	ENOG4107QME	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
EW640_RS02120	ENOG4107ZFB	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
EW640_RS02140	ENOG4107VEG	TrkA-N domain protein
EW640_RS02145	ENOG4105C0X	amino acid
EW640_RS02150	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
EW640_RS02155	ENOG4107QM5	aconitate hydratase
EW640_RS02160	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
EW640_RS02190	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
EW640_RS02200	ENOG4107JTW	chlorite dismutase
EW640_RS02205	ENOG4107YB6	acetyltransferase, (GNAT) family
EW640_RS02210	ENOG4105E0X	reductase
EW640_RS02220	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
EW640_RS02240	ENOG4107QXN	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
EW640_RS02250	ENOG4106DBE	Involved in DNA repair and RecF pathway recombination (By similarity)
EW640_RS02255	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
EW640_RS02280	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
EW640_RS02305	ENOG4105CSH	Transporter
EW640_RS02315	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
EW640_RS02320	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
EW640_RS02325	ENOG4108JQ1	Dehydrogenase
EW640_RS02345	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
EW640_RS02365	ENOG4108VX5	3-methyladenine DNA glycosylase
EW640_RS02370	ENOG4107H3J	ribonuclease
EW640_RS02375	ENOG4105CSR	polyphosphate kinase 2
EW640_RS02380	ENOG4108IQE	Amp-dependent synthetase and ligase
EW640_RS02385	ENOG4105C8T	Leucyl-tRNA synthetase
EW640_RS02390	ENOG4105C4K	Nad synthetase
EW640_RS02400	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
EW640_RS02405	ENOG4105EPR	degv family
EW640_RS02410	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
EW640_RS02425	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
EW640_RS02440	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
EW640_RS02465	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
EW640_RS02470	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
EW640_RS02475	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
EW640_RS02480	ENOG4105C9A	Phoh family
EW640_RS02485	ENOG4107VNR	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
EW640_RS02495	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
EW640_RS02500	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
EW640_RS02505	ENOG4105CSR	polyphosphate kinase 2
EW640_RS02540	ENOG4105C22	threonyL-tRNA synthetase
EW640_RS02550	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
EW640_RS02560	ENOG4105CDY	transcriptional regulatory protein
EW640_RS02565	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
EW640_RS02570	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
EW640_RS02575	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
EW640_RS02585	ENOG4107RSV	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
EW640_RS02590	ENOG4107RTU	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
EW640_RS02595	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
EW640_RS02605	ENOG4105C99	atpase involved in dna repair
EW640_RS02615	ENOG4105CUT	histidyl-tRNA synthetase
EW640_RS02620	ENOG41082SX	arsR family transcriptional regulator
EW640_RS02625	ENOG4105C9M	aspartyl-trna synthetase
EW640_RS02635	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
EW640_RS02640	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
EW640_RS02645	ENOG41080G3	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
EW640_RS02650	ENOG4105HHA	aminodeoxychorismate lyase
EW640_RS02655	ENOG4105E2X	shikimate dehydrogenase
EW640_RS02665	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
EW640_RS02670	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
EW640_RS02675	ENOG4105D49	3-dehydroquinate synthase
EW640_RS02680	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
EW640_RS02685	ENOG410803B	Involved in the transcription termination process (By similarity)
EW640_RS02695	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
EW640_RS02700	ENOG4105CXT	aspartate transcarbamylase
EW640_RS02705	ENOG4105CD3	dihydroorotase
EW640_RS02715	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
EW640_RS02720	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
EW640_RS02725	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
EW640_RS02730	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
EW640_RS02735	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
EW640_RS02740	ENOG4105MTQ	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
EW640_RS02760	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
EW640_RS02770	ENOG4105DJV	ribulose-phosphate 3-epimerase
EW640_RS02785	ENOG4105WH1	Two component transcriptional regulator luxr family
EW640_RS02790	ENOG4105DA5	(ABC) transporter
EW640_RS02800	ENOG4105M0N	phosphoribosyl-ATP pyrophosphatase
EW640_RS02805	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
EW640_RS02825	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
EW640_RS02830	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
EW640_RS02835	ENOG4105CRQ	synthase (Component I)
EW640_RS02850	ENOG4105DK0	Indole-3-glycerol phosphate synthase
EW640_RS02855	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
EW640_RS02860	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
EW640_RS02865	ENOG4107TBN	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
EW640_RS02870	ENOG4105CA9	Pyruvate kinase
EW640_RS02875	ENOG41082T9	Membrane
EW640_RS02890	ENOG4105KA0	thioesterase Superfamily protein
EW640_RS02935	ENOG4105J1P	transposase, IS3 IS911 family protein
EW640_RS02975	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
EW640_RS03025	ENOG4105KA0	thioesterase Superfamily protein
EW640_RS03035	ENOG4108YRB	methyltransferase
EW640_RS03040	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
EW640_RS03050	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
EW640_RS03055	ENOG4108Z9K	Osmotically inducible protein
EW640_RS03060	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
EW640_RS03080	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
EW640_RS03085	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
EW640_RS03090	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
EW640_RS03095	ENOG4105CHW	UPF0052 protein
EW640_RS03100	ENOG4105CIE	May be required for sporulation (By similarity)
EW640_RS03105	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
EW640_RS03110	ENOG4105BZA	Phosphoglycerate kinase
EW640_RS03115	ENOG4105CP7	Triose-phosphate isomerase
EW640_RS03125	ENOG4107QYV	phosphohexose isomerase
EW640_RS03130	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
EW640_RS03140	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
EW640_RS03170	ENOG4105DIW	FeS assembly protein SUFB
EW640_RS03175	ENOG4105JRK	feS assembly protein SufD
EW640_RS03185	ENOG4105C3K	feS assembly ATPase SufC
EW640_RS03195	ENOG4108UNV	SUF system FeS assembly protein, NifU family
EW640_RS03200	ENOG4105VG1	fes assembly suf system protein
EW640_RS03210	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
EW640_RS03215	ENOG4105C5H	ABC transporter
EW640_RS03235	ENOG4105CHR	reductase
EW640_RS03240	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
EW640_RS03250	ENOG4105EAC	phosphoserine phosphatase
EW640_RS03260	ENOG4105DKW	ABC transporter
EW640_RS03270	ENOG4105FCS	tRNA rRNA methyltransferase
EW640_RS03280	ENOG4108XFF	
EW640_RS03290	ENOG4105NRA	50s ribosomal protein l31 type b
EW640_RS03295	ENOG4105DWF	phosphomethylpyrimidine kinase
EW640_RS03300	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
EW640_RS03315	ENOG4105C0B	DNA polymerase III (alpha subunit)
EW640_RS03320	ENOG4108IQK	o-acetylhomoserine
EW640_RS03325	ENOG4105DWV	Homoserine O-trans-acetylase
EW640_RS03330	ENOG4105C1G	acyl-Coa dehydrogenase
EW640_RS03340	ENOG4105CHU	acetyl-coa acetyltransferase
EW640_RS03345	ENOG4105CHR	reductase
EW640_RS03390	ENOG4105CVJ	phosphoglycerate mutase
EW640_RS03395	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
EW640_RS03400	ENOG4105CPC	Aldo Keto reductase
EW640_RS03420	ENOG4105C8N	cysteinyl-tRNA synthetase
EW640_RS03430	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
EW640_RS03450	ENOG4105DHM	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity)
EW640_RS03460	ENOG4105E5F	proteasome
EW640_RS03465	ENOG4105WFD	Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity)
EW640_RS03470	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
EW640_RS03475	ENOG4105F7N	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
EW640_RS03510	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
EW640_RS03515	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
EW640_RS03525	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
EW640_RS03530	ENOG4105HFS	5'-3' exonuclease
EW640_RS03540	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
EW640_RS03545	ENOG4105Q70	
EW640_RS03550	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
EW640_RS03560	ENOG4105K6T	rare lipoprotein A
EW640_RS03580	ENOG4108ZJ4	polysaccharide deacetylase
EW640_RS03595	ENOG4105CB2	alcohol dehydrogenase
EW640_RS03620	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
EW640_RS03625	ENOG4108JIJ	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)
EW640_RS03630	ENOG4107RH8	nuclease SbcCD subunit D
EW640_RS03635	ENOG4105EYH	Exonuclease
EW640_RS03640	ENOG4107QJE	Chromosome Partitioning Protein
EW640_RS03650	ENOG4105F6E	Acyl-transferase
EW640_RS03675	ENOG4108I0Q	anthranilate phosphoribosyltransferase
EW640_RS03680	ENOG4105CCU	oxidase (Subunit III)
EW640_RS03685	ENOG4107UDY	cytochrome C
EW640_RS03690	ENOG4107EUI	c reductase, iron-sulfur
EW640_RS03695	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
EW640_RS03700	ENOG4108ZRS	Part of cytochrome c oxidase, its function is
EW640_RS03705	ENOG4105BZ9	Cytochrome C oxidase, subunit I
EW640_RS03710	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
EW640_RS03715	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
EW640_RS03725	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
EW640_RS03735	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
EW640_RS03740	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
EW640_RS03760	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
EW640_RS03765	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
EW640_RS03780	ENOG4105C5F	glutamine synthetase
EW640_RS03790	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
EW640_RS03795	ENOG4105C5F	glutamine synthetase
EW640_RS03805	ENOG4105DCF	alanine dehydrogenase
EW640_RS03815	ENOG4105DFK	Polyphosphate glucokinase
EW640_RS03820	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
EW640_RS03825	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
EW640_RS03830	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
EW640_RS03835	ENOG4107WHG	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
EW640_RS03850	ENOG4107XFJ	UPF0246 protein
EW640_RS03860	ENOG4105EGD	dinuclear metal center protein, YbgI family
EW640_RS03865	ENOG4105CEY	Amp-dependent synthetase and ligase
EW640_RS03905	ENOG4105ECQ	AraC Family Transcriptional Regulator
EW640_RS03920	ENOG410829K	Lysine exporter protein (Lyse ygga)
EW640_RS03925	ENOG4105C57	major facilitator superfamily
EW640_RS03940	ENOG4105CHR	reductase
EW640_RS03945	ENOG4105CS1	NAD(P)H quinone oxidoreductase
EW640_RS03960	ENOG4105KPY	Small multidrug resistance protein
EW640_RS03965	ENOG4105KPY	Small multidrug resistance protein
EW640_RS04005	ENOG4108M15	ABC transporter
EW640_RS04015	ENOG4105CSH	Transporter
EW640_RS04025	ENOG41069M3	Transcriptional regulator
EW640_RS04045	ENOG4108R3E	Dna-3-methyladenine glycosylase i
EW640_RS04050	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
EW640_RS04075	ENOG4107XI7	Tetr family transcriptional regulator
EW640_RS04095	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
EW640_RS04110	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
EW640_RS04115	ENOG41082KT	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
EW640_RS04120	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
EW640_RS04135	ENOG4105DIM	ABC transporter
EW640_RS04140	ENOG4105CIG	ABC transporter
EW640_RS04145	ENOG4108X07	Tetr family transcriptional regulator
EW640_RS04165	ENOG4105C57	major facilitator superfamily
EW640_RS04170	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
EW640_RS04175	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
EW640_RS04205	ENOG4105EGD	dinuclear metal center protein, YbgI family
EW640_RS04215	ENOG4105C7K	acetolactate synthase
EW640_RS04290	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
EW640_RS04305	ENOG4108KQ5	Integrase catalytic subunit
EW640_RS04310	ENOG4105E7U	AraC family transcriptional regulator
EW640_RS04320	ENOG4105VPX	protein, conserved in bacteria
EW640_RS04355	ENOG4105C57	major facilitator superfamily
EW640_RS04365	ENOG4108EQM	faD-dependent pyridine nucleotide-disulfide oxidoreductase
EW640_RS04405	ENOG4105SC1	monovalent cation H antiporter subunit E
EW640_RS04410	ENOG4108JPZ	Monovalent cation H antiporter subunit D
EW640_RS04415	ENOG4105MKQ	Monovalent cation H antiporter subunit C
EW640_RS04420	ENOG4105D65	subunit l
EW640_RS04425	ENOG4108TJN	glycosyl transferase group 1
EW640_RS04430	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
EW640_RS04445	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
EW640_RS04455	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
EW640_RS04460	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
EW640_RS04465	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EW640_RS04470	ENOG4105K46	50S ribosomal protein l27
EW640_RS04475	ENOG410826X	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
EW640_RS04480	ENOG4105EHE	chorismate mutase- prephenate dehydrogenase
EW640_RS04490	ENOG4105BZG	amino acid carrier protein
EW640_RS04495	ENOG4105C03	ribonuclease
EW640_RS04515	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
EW640_RS04540	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
EW640_RS04550	ENOG41082BM	Transcriptional regulator, arsr family
EW640_RS04560	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
EW640_RS04565	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
EW640_RS04570	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
EW640_RS04575	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
EW640_RS04625	ENOG4108YZG	isomerase
EW640_RS04630	ENOG4105MC2	DSBA oxidoreductase
EW640_RS04640	ENOG4105D8X	mechanosensitive ion channel
EW640_RS04660	ENOG4105C29	acyl-CoA thioesterase
EW640_RS04700	ENOG4105CHU	acetyl-coa acetyltransferase
EW640_RS04715	ENOG4105CYV	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity)
EW640_RS04720	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
EW640_RS04730	ENOG410825K	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
EW640_RS04735	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
EW640_RS04740	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
EW640_RS04745	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
EW640_RS04750	ENOG4108T62	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
EW640_RS04755	ENOG4107Z0K	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
EW640_RS04760	ENOG4105ZA1	atp synthase
EW640_RS04765	ENOG4107UH5	it plays a direct role in the translocation of protons across the membrane (By similarity)
EW640_RS04775	ENOG4105ESV	Glycosyl transferase, family 4
EW640_RS04780	ENOG4107UIY	sua5 ycio yrdc ywlc family protein
EW640_RS04785	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
EW640_RS04790	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
EW640_RS04800	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
EW640_RS04805	ENOG4107R5I	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
EW640_RS04810	ENOG4105D6E	homoserine dehydrogenase
EW640_RS04820	ENOG4105C75	arginyL-tRNA synthetase
EW640_RS04920	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
EW640_RS04935	ENOG4105EMN	RNA polymerase sigma factor
EW640_RS04940	ENOG4105VEQ	Cold shock protein
EW640_RS04955	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
EW640_RS04965	ENOG4107TK4	histidinol-phosphate phosphatase
EW640_RS04975	ENOG4105DJ2	Major Facilitator Superfamily
EW640_RS04985	ENOG4105DJZ	UPF0182 protein
EW640_RS04990	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
EW640_RS05035	ENOG4105C5N	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EW640_RS05040	ENOG4107XI7	Tetr family transcriptional regulator
EW640_RS05060	ENOG4105DB7	PHP domain protein
EW640_RS05065	ENOG4107T6F	Xaa-Pro aminopeptidase
EW640_RS05120	ENOG4108URH	decarboxylase
EW640_RS05125	ENOG4105EJ3	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)
EW640_RS05140	ENOG4108Z4U	Ferredoxin
EW640_RS05160	ENOG4105CWN	amidohydrolase
EW640_RS05165	ENOG41073R8	VanW family
EW640_RS05170	ENOG4108KZ5	Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity)
EW640_RS05175	ENOG4105CI3	gtp-binding protein typa
EW640_RS05180	ENOG4105WH1	Two component transcriptional regulator luxr family
EW640_RS05210	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
EW640_RS05235	ENOG4105KPY	Small multidrug resistance protein
EW640_RS05245	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
EW640_RS05250	ENOG4105C8P	)-transporter
EW640_RS05255	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
EW640_RS05260	ENOG4107104	thymidine kinase
EW640_RS05280	ENOG4108UVJ	appr-1-p processing domain protein
EW640_RS05290	ENOG4108UKZ	OsmC family
EW640_RS05295	ENOG4105DUX	Transporter
EW640_RS05300	ENOG4105CKW	Inner membrane protein yedI
EW640_RS05310	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
EW640_RS05340	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
EW640_RS05345	ENOG4105D3R	alkyl hydroperoxide reductase
EW640_RS05375	ENOG4105K5B	UPF0225 protein
EW640_RS05390	ENOG4105EV9	Alpha Beta Hydrolase
EW640_RS05405	ENOG4105KT7	mgtC SapB transporter
EW640_RS05420	ENOG4105C94	Transporter
EW640_RS05465	ENOG4105D7A	ATP-binding protein
EW640_RS05500	ENOG4105DQE	DNA ligase
EW640_RS05505	ENOG4105FDF	Could be involved in DNA repair (By similarity)
EW640_RS05515	ENOG4108V0E	nucleoside 2-deoxyribosyltransferase YtoQ
EW640_RS05520	ENOG4108KQ5	Integrase catalytic subunit
EW640_RS05525	ENOG4106HB6	Alpha beta hydrolase
EW640_RS05610	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
EW640_RS05615	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
EW640_RS05625	ENOG4105C3G	gtp-binding protein
EW640_RS05640	ENOG4108UGD	Serine Threonine protein kinase
EW640_RS05645	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
EW640_RS05650	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
EW640_RS05655	ENOG4105YX8	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
EW640_RS05670	ENOG4108V9Q	carbonic anhydrase
EW640_RS05675	ENOG4105C9Q	fumarate hydratase class II
EW640_RS05680	ENOG4108IAB	Phoh family
EW640_RS05685	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
EW640_RS05700	ENOG4105T1M	mycothiol conjugate amidase mca
EW640_RS05710	ENOG4107YD5	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
EW640_RS05725	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
EW640_RS05730	ENOG4105CSH	Transporter
EW640_RS05745	ENOG4108JIK	carboxylase
EW640_RS05760	ENOG4108Z0R	Transferase
EW640_RS05775	ENOG4105C7I	Dehydrogenase
EW640_RS05820	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
EW640_RS05825	ENOG4105T0Z	Conserved Protein
EW640_RS05830	ENOG4108S7Q	sigma 54 modulation protein ribosomal protein S30ea
EW640_RS05845	ENOG4105BZU	Histidine kinase
EW640_RS05850	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
EW640_RS05870	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
EW640_RS05895	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
EW640_RS05900	ENOG4107QKV	phosphomannomutase
EW640_RS05925	ENOG4105K51	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
EW640_RS05930	ENOG41088YA	Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity)
EW640_RS05955	ENOG4105EIP	mannose-6-phosphate isomerase
EW640_RS05965	ENOG4108KGH	TRANSCRIPTIONal
EW640_RS06020	ENOG410870F	Cyclic nucleotide-binding protein
EW640_RS06025	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
EW640_RS06055	ENOG4105D8K	carboxyl transferase
EW640_RS06070	ENOG4105DZR	Type I site-specific deoxyribonuclease
EW640_RS06085	ENOG4105CVR	type I restriction-modification system
EW640_RS06100	ENOG4107V0Z	fmn reductase
EW640_RS06130	ENOG4105C54	Major Facilitator superfamily
EW640_RS06140	ENOG4105CZM	Major Facilitator
EW640_RS06150	ENOG4105CZM	Major Facilitator
EW640_RS06155	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
EW640_RS06160	ENOG410835K	Tripartite ATP-Independent Periplasmic transporter DctQ
EW640_RS06165	ENOG41085JF	Trap dicarboxylate transporter-dctp subunit
EW640_RS06200	ENOG4105CFC	Transporter
EW640_RS06210	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
EW640_RS06220	ENOG4105CQ7	ATP-dependent helicase
EW640_RS06240	ENOG4105EYW	Ion transport protein
EW640_RS06250	ENOG4105PGM	cation diffusion facilitator family transporter
EW640_RS06270	ENOG4105E2A	Dehydrogenase
EW640_RS06280	ENOG4105CEP	NADH dehydrogenase
EW640_RS06285	ENOG41090GG	peptidase S8 and S53, subtilisin, kexin, sedolisin
EW640_RS06305	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
EW640_RS06315	ENOG4105DXN	mazG family
EW640_RS06330	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
EW640_RS06340	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
EW640_RS06345	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
EW640_RS06375	ENOG4105DC1	bifunctional purine biosynthesis protein purh
EW640_RS06410	ENOG4105HAC	ABC-2 type transporter
EW640_RS06415	ENOG4105DV0	amidase (EC 3.5.1.4
EW640_RS06425	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
EW640_RS06435	ENOG4105DEF	Extracellular solute-binding protein, family 5
EW640_RS06445	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
EW640_RS06450	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
EW640_RS06455	ENOG4108RQ5	Beta-lactamase domain-containing protein
EW640_RS06465	ENOG4105KEN	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
EW640_RS06490	ENOG4105D82	Glutamate dehydrogenase
EW640_RS06525	ENOG4108RAV	Conserved protein
EW640_RS06540	ENOG4105C1G	acyl-Coa dehydrogenase
EW640_RS06545	ENOG4105E39	Enoyl-CoA hydratase
EW640_RS06575	ENOG4105CKI	cobalamin synthesis protein
EW640_RS06580	ENOG4107R3N	Filamentation induced by cAMP protein fic
EW640_RS06590	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
EW640_RS06595	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
EW640_RS06605	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
EW640_RS06645	ENOG4105C7K	acetolactate synthase
EW640_RS06655	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
EW640_RS06670	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
EW640_RS06680	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
EW640_RS06685	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
EW640_RS06705	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
EW640_RS06725	ENOG4105CAK	Cell division ATP-binding protein ftsE
EW640_RS06730	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
EW640_RS06800	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
EW640_RS06805	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
EW640_RS06825	ENOG4105UIB	(ABC) transporter
EW640_RS06830	ENOG4108JQ9	ABC transporter
EW640_RS06835	ENOG4105DIH	basic membrane
EW640_RS06845	ENOG4105C5H	ABC transporter
EW640_RS06860	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
EW640_RS06865	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
EW640_RS06880	ENOG4108VCA	G U mismatch-specific DNA glycosylase
EW640_RS06890	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
EW640_RS06895	ENOG4106KXD	ATP-dependent carboxylate-amine ligase (By similarity)
EW640_RS06905	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
EW640_RS06915	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
EW640_RS06925	ENOG4108097	ATP-binding protein
EW640_RS06930	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
EW640_RS06935	ENOG4107QTJ	carbohydrate kinase, YjeF related protein
EW640_RS06940	ENOG4105CH2	amidohydrolase
EW640_RS06950	ENOG41082KK	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
EW640_RS06955	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
EW640_RS06970	ENOG4105CUB	amino acid
EW640_RS06975	ENOG4105CS9	pantothenic acid kinase
EW640_RS06980	ENOG4105BZ1	(ABC) transporter
EW640_RS07020	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
EW640_RS07025	ENOG4108UJD	30S ribosomal protein S9
EW640_RS07030	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
EW640_RS07045	ENOG4105CGH	5'-nucleotidase
EW640_RS07050	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
EW640_RS07065	ENOG4107QCX	Transporter
EW640_RS07070	ENOG4108JJB	ABC transporter
EW640_RS07075	ENOG4107ZYJ	bioY protein
EW640_RS07080	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
EW640_RS07095	ENOG4107QVP	Dehydrogenase
EW640_RS07125	ENOG4105RQF	LysR family Transcriptional regulator
EW640_RS07140	ENOG4105DWF	phosphomethylpyrimidine kinase
EW640_RS07145	ENOG4105DWF	phosphomethylpyrimidine kinase
EW640_RS07150	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
EW640_RS07165	ENOG4105C29	acyl-CoA thioesterase
EW640_RS07170	ENOG4105DSE	periplasmic solute binding protein
EW640_RS07175	ENOG4105DIK	(ABC) transporter
EW640_RS07185	ENOG4107R5H	iron (metal) dependent repressor, dtxr family
EW640_RS07190	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
EW640_RS07195	ENOG4105ETE	Transcriptional regulator (LacI family
EW640_RS07200	ENOG4105CIF	Ornithine Cyclodeaminase
EW640_RS07210	ENOG4105E5Q	amino acid AbC transporter
EW640_RS07215	ENOG4105CT1	(ABC) transporter
EW640_RS07220	ENOG4108KPW	sugar kinase
EW640_RS07240	ENOG4105D3G	Pseudouridine synthase
EW640_RS07250	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
EW640_RS07255	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
EW640_RS07275	ENOG4105F8V	Hydrolase, tatD family
EW640_RS07310	ENOG4105F0R	Cytidylyltransferase
EW640_RS07315	ENOG4105D2T	synthase
EW640_RS07320	ENOG4107QRS	glycosyltransferase group 2 family protein
EW640_RS07340	ENOG41089I4	Inherit from COG: Glycosyl transferase, family 2
EW640_RS07350	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
EW640_RS07355	ENOG4108UMI	ABC transporter, permease
EW640_RS07360	ENOG4105D01	(LipO)protein
EW640_RS07365	ENOG4105CKU	formyltetrahydrofolate synthetase
EW640_RS07385	ENOG4108I69	Glycosyl transferases group 1
EW640_RS07400	ENOG4105CMR	udp-glucose 4-epimerase
EW640_RS07405	ENOG4107YSK	Glycerol-3-phosphate cytidylyltransferase
EW640_RS07420	ENOG4105CPC	Aldo Keto reductase
EW640_RS07440	ENOG4105CRW	Short chain fatty acid transporter
EW640_RS07450	ENOG4105C26	Dehydrogenase
EW640_RS07460	ENOG4105F35	Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity)
EW640_RS07470	ENOG4105CEY	Amp-dependent synthetase and ligase
EW640_RS07475	ENOG4108UKI	Enoyl-CoA hydratase
EW640_RS07490	ENOG4105CHU	acetyl-coa acetyltransferase
EW640_RS07495	ENOG4105XDZ	Tripartite ATP-independent periplasmic transporter
EW640_RS07500	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
EW640_RS07505	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
EW640_RS07520	ENOG4107ZR7	Membrane
EW640_RS07530	ENOG4105J0Q	Transcriptional regulator
EW640_RS07600	ENOG41080UU	5-formyltetrahydrofolate cyclo-ligase
EW640_RS07640	ENOG4105C9U	ATP-dependent DNA helicase RecQ
EW640_RS07645	ENOG4105BZ1	(ABC) transporter
EW640_RS07650	ENOG4105BZ1	(ABC) transporter
EW640_RS07675	ENOG4105ES4	Nitrilase
EW640_RS07685	ENOG4105CSR	polyphosphate kinase 2
EW640_RS07715	ENOG4108FKR	NLP P60 protein
EW640_RS07725	ENOG4105C26	Dehydrogenase
EW640_RS07730	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
EW640_RS07735	ENOG4107R8H	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
EW640_RS07755	ENOG4105VEQ	Cold shock protein
EW640_RS07770	ENOG4105CFI	type iii restriction protein res subunit
EW640_RS07790	ENOG4105CBC	glutamate synthase
EW640_RS07795	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
EW640_RS07800	ENOG4105BZU	Histidine kinase
EW640_RS07810	ENOG4105C0H	protease
EW640_RS07830	ENOG4105D0M	Protease HtpX homolog
EW640_RS07855	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
EW640_RS07880	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
EW640_RS07885	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
EW640_RS07895	ENOG4105CI2	imidazolone-5-propionate hydrolase
EW640_RS07900	ENOG41063V1	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
EW640_RS07905	ENOG4105C7N	Xanthine uracil vitamin C permease
EW640_RS07910	ENOG4106F59	XRE family Transcriptional regulator
EW640_RS07930	ENOG4105I7Z	Short-chain dehydrogenase reductase Sdr
EW640_RS07940	ENOG41083TI	Protein CrcB homolog
EW640_RS07945	ENOG4105WMR	Protein CrcB homolog
EW640_RS07950	ENOG4108YYC	ycei family
EW640_RS07960	ENOG4105EVE	HAD-superfamily hydrolase subfamily IA variant 3
EW640_RS07965	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
EW640_RS07985	ENOG4108762	serine threonine protein kinase
EW640_RS07990	ENOG4105C1K	alpha-alpha-trehalose-phosphate synthase
EW640_RS08000	ENOG4105ETE	Transcriptional regulator (LacI family
EW640_RS08010	ENOG4105CHR	reductase
EW640_RS08020	ENOG4105C2N	RNA methyltransferase TrmH family group 3
EW640_RS08025	ENOG4105C8N	cysteinyl-tRNA synthetase
EW640_RS08040	ENOG4105C8J	)-transporter
EW640_RS08055	ENOG4107VMB	Beta-lactamase domain protein
EW640_RS08070	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
EW640_RS08075	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
EW640_RS08095	ENOG4105BZU	Histidine kinase
EW640_RS08105	ENOG4108594	Permease of the drug metabolite transporter
EW640_RS08110	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
EW640_RS08125	ENOG4108RAV	Conserved protein
EW640_RS08140	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
EW640_RS08180	ENOG4108A04	Beta-lactamase
EW640_RS08185	ENOG4105DEN	Luciferase family
EW640_RS08190	ENOG4105C09	Bile acid
EW640_RS08255	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
EW640_RS08265	ENOG4108X6U	May play a role in the intracellular transport of hydrophobic ligands
EW640_RS08275	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
EW640_RS08290	ENOG4107QJG	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
EW640_RS08305	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
EW640_RS08345	ENOG4105D29	Helix-turn-helix type 11 domain protein
EW640_RS08410	ENOG4107YCY	Transcriptional regulator
EW640_RS08415	ENOG4105E3J	oxidoreductase
EW640_RS08450	ENOG4105E7W	lamb ycsf family protein
EW640_RS08460	ENOG4108JIK	carboxylase
EW640_RS08470	ENOG4105CFM	UPF0317 protein
EW640_RS08475	ENOG4105C5A	transporter
EW640_RS08485	ENOG4105W1N	transcriptional regulator
EW640_RS08490	ENOG4105E89	ABC transporter
EW640_RS08495	ENOG4105EAD	ABC transporter
EW640_RS08505	ENOG4108HW3	(ABC) transporter
EW640_RS08520	ENOG4105CSH	Transporter
EW640_RS08530	ENOG4105C7K	acetolactate synthase
EW640_RS08540	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
EW640_RS08545	ENOG4108Z66	YbaK ebsC protein
EW640_RS08585	ENOG4105CE7	Amidase, hydantoinase carbamoylase family
EW640_RS08620	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
EW640_RS08670	ENOG4105C12	Phosphoribosylglycinamide synthetase
EW640_RS08675	ENOG4105C8V	SAICAR synthetase
EW640_RS08685	ENOG410839H	phosphoribosylformylglycinamidine synthase
EW640_RS08690	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
EW640_RS08720	ENOG4105C72	UPF0176 protein
EW640_RS08730	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
EW640_RS08740	ENOG4105C94	Transporter
EW640_RS08780	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
EW640_RS08800	ENOG4105EY8	ABC transporter
EW640_RS08810	ENOG4108EQM	faD-dependent pyridine nucleotide-disulfide oxidoreductase
EW640_RS08825	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
EW640_RS08830	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
EW640_RS08840	ENOG4105BZG	amino acid carrier protein
EW640_RS08865	ENOG4108IA2	Sodium pantothenate symporter
EW640_RS08870	ENOG4105ETE	Transcriptional regulator (LacI family
EW640_RS08905	ENOG4105NX3	Membrane
EW640_RS08920	ENOG4105X7H	acyl-CoA dehydrogenase
EW640_RS08925	ENOG4105C1G	acyl-Coa dehydrogenase
EW640_RS08965	ENOG4108IUX	(ABC) transporter
EW640_RS08970	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
EW640_RS08985	ENOG4105CQB	FAD linked oxidase domain protein
EW640_RS09000	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
EW640_RS09010	ENOG4105VT3	DNA binding domain protein, excisionase family
EW640_RS09015	ENOG4105E39	Enoyl-CoA hydratase
EW640_RS09035	ENOG4105CEU	Arginine dihydrolase
EW640_RS09060	ENOG4105VT3	DNA binding domain protein, excisionase family
EW640_RS09080	ENOG4105F27	Major Facilitator
EW640_RS09090	ENOG4107DZG	Ribbon-helix-helix protein, copG family
EW640_RS09105	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
EW640_RS09125	ENOG4105CHR	reductase
EW640_RS09130	ENOG4108MES	Periplasmic binding protein
EW640_RS09140	ENOG4105CM4	permease protein
EW640_RS09145	ENOG4108IPW	abc transporter atp-binding protein
EW640_RS09155	ENOG410841Q	phosphoesterase PA-phosphatase related protein
EW640_RS09165	ENOG4108MXC	l-carnitine dehydratase bile acid-inducible protein F
EW640_RS09175	ENOG4105CHU	acetyl-coa acetyltransferase
EW640_RS09180	ENOG4105BZJ	Electron transfer flavoprotein
EW640_RS09205	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
EW640_RS09225	ENOG4105C6K	Malic enzyme
EW640_RS09235	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
EW640_RS09255	ENOG4108FUF	Transcriptional regulator, IclR family
EW640_RS09270	ENOG4105S0E	allantoin catabolism protein
EW640_RS09285	ENOG4108N16	Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region
EW640_RS09310	ENOG4105BZW	Glycerate kinase
EW640_RS09325	ENOG41060W2	glyoxylate carboligase
EW640_RS09330	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
EW640_RS09335	ENOG4107TFQ	Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity)
EW640_RS09340	ENOG4105C2W	permease
EW640_RS09350	ENOG4105CKI	cobalamin synthesis protein
EW640_RS09370	ENOG4105J1P	transposase, IS3 IS911 family protein
EW640_RS09390	ENOG4108KQ5	Integrase catalytic subunit
EW640_RS09395	ENOG4107QUY	Guanine deaminase
EW640_RS09405	ENOG4105C7W	Xanthine dehydrogenase
EW640_RS09415	ENOG4105C7N	Xanthine uracil vitamin C permease
EW640_RS09460	ENOG4105E39	Enoyl-CoA hydratase
EW640_RS09470	ENOG4105C7K	acetolactate synthase
EW640_RS09480	ENOG4105QPS	Monooxygenase
EW640_RS09495	ENOG4105C26	Dehydrogenase
EW640_RS09520	ENOG4107SCA	Formamidase (EC 3.5.1.49)
EW640_RS09530	ENOG4105KZX	Pterin carbinolamine dehydratase
EW640_RS09555	ENOG4105CHR	reductase
EW640_RS09560	ENOG4107QIV	Cytochrome c biogenesis protein
EW640_RS09570	ENOG4105E2T	synthase III
EW640_RS09575	ENOG410680H	amp-dependent synthetase and ligase
EW640_RS09580	ENOG4107VBM	3-beta hydroxysteroid dehydrogenase isomerase
EW640_RS09600	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
EW640_RS09630	ENOG4105CIH	Imidazole acetol-phosphate transaminase
EW640_RS09645	ENOG4105DTQ	mandelate racemase muconate lactonizing
EW640_RS09650	ENOG4105EYF	MMPL domain protein
EW640_RS09670	ENOG4108VCT	Sulfite exporter TauE/SafE
EW640_RS09680	ENOG4105ENR	peptidase, M24
EW640_RS09685	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
EW640_RS09695	ENOG4105FF2	Type I DHQase
EW640_RS09715	ENOG4108IJ7	Glycine betaine
EW640_RS09720	ENOG4107U14	binding-protein-dependent transport systems inner membrane Component
EW640_RS09745	ENOG4107QUT	magnesium and cobalt transport protein CorA
EW640_RS09755	ENOG4105D29	Helix-turn-helix type 11 domain protein
EW640_RS09770	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
EW640_RS09850	ENOG4108KQ5	Integrase catalytic subunit
EW640_RS09855	ENOG4105VE1	Phosphatidylcholine synthase
EW640_RS09860	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
EW640_RS09880	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
EW640_RS09885	ENOG4105KJM	monovalent cation h antiporter subunit g
EW640_RS09890	ENOG410684G	monovalent cation H antiporter subunit F
EW640_RS09900	ENOG4108JPZ	Monovalent cation H antiporter subunit D
EW640_RS09905	ENOG4105MKQ	Monovalent cation H antiporter subunit C
EW640_RS09910	ENOG4105D65	subunit l
EW640_RS09920	ENOG4105DHP	deoxycytidine triphosphate deaminase
EW640_RS09945	ENOG4105DFA	alanine racemase domain protein
EW640_RS09965	ENOG4105K70	DNA-binding protein
EW640_RS09970	ENOG41080FR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
EW640_RS09975	ENOG4105W0E	50S ribosomal protein L33
EW640_RS09990	ENOG4107RN0	branched-chain alpha-keto acid dehydrogenase subunit E2
EW640_RS09995	ENOG4105CPP	Dehydrogenase, E1 component
EW640_RS10025	ENOG4107QTF	adenylosuccinate lyase
EW640_RS10050	ENOG4105C26	Dehydrogenase
EW640_RS10055	ENOG4105VPX	protein, conserved in bacteria
EW640_RS10080	ENOG4108PYU	two-component system response regulator
EW640_RS10085	ENOG4108FKE	two-component system sensor kinase
EW640_RS10100	ENOG4105BZP	glycoside hydrolase 15-related
EW640_RS10105	ENOG4105NAU	thioesterase Superfamily protein
EW640_RS10125	ENOG4105BZ1	(ABC) transporter
EW640_RS10140	ENOG4107RAX	Methyltransferase
EW640_RS10185	ENOG410900G	Protein of unknown function (DUF421)
EW640_RS10205	ENOG4105T38	integral membrane protein
EW640_RS10215	ENOG4105EN6	Membrane
EW640_RS10250	ENOG410814C	multidrug resistance protein
EW640_RS10280	ENOG4105CDU	Replicative dna helicase
EW640_RS10305	ENOG4108KQ5	Integrase catalytic subunit
EW640_RS10310	ENOG4107RSM	transcriptional regulator
EW640_RS10325	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
EW640_RS10330	ENOG4106BRA	Membrane
EW640_RS10340	ENOG4107TXC	Transcriptional regulator
EW640_RS10345	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
EW640_RS10350	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
EW640_RS10360	ENOG410829C	Binds together with S18 to 16S ribosomal RNA (By similarity)
EW640_RS10370	ENOG4105BZ4	penicillin-binding protein
EW640_RS10375	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
EW640_RS10380	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
EW640_RS10405	ENOG4105C3M	thioredoxin reductase
EW640_RS10410	ENOG4105K63	Thioredoxin
EW640_RS10415	ENOG4108E1C	hydrolase
EW640_RS10420	ENOG4105FA0	parb-like partition protein
EW640_RS10425	ENOG4107QJE	Chromosome Partitioning Protein
EW640_RS10430	ENOG4107XUG	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
EW640_RS10440	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
EW640_RS10445	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
EW640_RS10450	ENOG4105XH8	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
EW640_RS10455	ENOG41084CH	50S ribosomal protein l34
EW640_RS10460	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
EW640_RS10465	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
EW640_RS10470	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
EW640_RS10485	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
EW640_RS10490	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
EW640_RS10510	ENOG4105EYG	tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity)
EW640_RS10525	ENOG4108KQ5	Integrase catalytic subunit
EW640_RS10530	ENOG4108C33	Resolvase
EW640_RS10540	ENOG4108Q5F	Tetr family transcriptional regulator
EW640_RS10550	ENOG4108C33	Resolvase
EW640_RS10565	ENOG4105FD8	phosphonate metabolism protein PhnM
EW640_RS10640	ENOG41083WA	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
EW640_RS10645	ENOG41082BM	Transcriptional regulator, arsr family
EW640_RS10660	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
EW640_RS10665	ENOG4105W1Y	Transcriptional regulator
EW640_RS10680	ENOG410836F	Transposase
EW640_RS10690	ENOG4105J1P	transposase, IS3 IS911 family protein
EW640_RS10725	ENOG4108KQ5	Integrase catalytic subunit
EW640_RS10750	ENOG4107STF	Involved in phosphonate degradation (By similarity)
EW640_RS10755	ENOG4105C94	Transporter
EW640_RS10770	ENOG4105DZ6	Band 7 protein
EW640_RS10795	ENOG4105BZU	Histidine kinase
EW640_RS10800	ENOG4105I2S	Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity)
EW640_RS10805	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
EW640_RS10820	ENOG4107XH4	PPIases accelerate the folding of proteins (By similarity)
EW640_RS10830	ENOG4108VW9	Membrane
EW640_RS10835	ENOG4105ZJT	Cell division protein CrgA
EW640_RS10855	ENOG4108U4N	(sortase) family
EW640_RS10875	ENOG4107TPY	serine threonine protein kinase
EW640_RS10880	ENOG4105CJN	penicillin-binding protein
EW640_RS10895	ENOG4105HZM	Fha domain containing protein
EW640_RS10915	ENOG4105CI2	imidazolone-5-propionate hydrolase
EW640_RS10935	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
EW640_RS10950	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
EW640_RS10960	ENOG4105F38	ABC transporter, permease
EW640_RS10970	ENOG4105CJP	fad dependent oxidoreductase
EW640_RS10980	ENOG4105C26	Dehydrogenase
EW640_RS10990	ENOG4105BZG	amino acid carrier protein
EW640_RS11005	ENOG4105K6H	D-cysteine desulfhydrase
EW640_RS11010	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
EW640_RS11025	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
EW640_RS11030	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
EW640_RS11035	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
EW640_RS11055	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
EW640_RS11060	ENOG4108ZHR	arsR family transcriptional regulator
EW640_RS11085	ENOG4108ZGX	Histidine kinase
EW640_RS11090	ENOG4105CJA	serine threonine protein kinase
EW640_RS11115	ENOG4105C57	major facilitator superfamily
EW640_RS11130	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
EW640_RS11145	ENOG4105DWF	phosphomethylpyrimidine kinase
EW640_RS11190	ENOG4108R85	Short chain dehydrogenase
EW640_RS11195	ENOG4105C9U	ATP-dependent DNA helicase RecQ
EW640_RS11200	ENOG4105D4F	Synthesizes selenophosphate from selenide and ATP (By similarity)
EW640_RS11210	ENOG4105C1Y	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity)
EW640_RS11215	ENOG4105EM7	Selenocysteine-specific translation elongation factor
EW640_RS11220	ENOG4105CPN	adenine deaminase
EW640_RS11230	ENOG4107QN1	sodium solute
EW640_RS11235	ENOG4107RN0	branched-chain alpha-keto acid dehydrogenase subunit E2
EW640_RS11270	ENOG4105DXM	phenylacetic acid degradation protein
EW640_RS11310	ENOG41079KZ	Major Facilitator Superfamily
EW640_RS11315	ENOG4105ETE	Transcriptional regulator (LacI family
EW640_RS11325	ENOG4105CRS	phenylacetate-CoA oxygenase PaaG subunit
EW640_RS11330	ENOG4105N76	Phenylacetate-CoA oxygenase, subunit
EW640_RS11335	ENOG4105D9S	phenylacetate-CoA oxygenase PaaI subunit
EW640_RS11340	ENOG4108ZA2	phenylacetate-CoA oxygenase PaaJ subunit
EW640_RS11345	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
EW640_RS11355	ENOG4105CHF	Glutathione S-transferase
EW640_RS11365	ENOG4105C1G	acyl-Coa dehydrogenase
EW640_RS11370	ENOG4108IA2	Sodium pantothenate symporter
EW640_RS11380	ENOG4107R3N	Filamentation induced by cAMP protein fic
EW640_RS11390	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
EW640_RS11400	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
EW640_RS11415	ENOG4105DJ2	Major Facilitator Superfamily
EW640_RS11435	ENOG4105JSC	dimethylmenaquinone methyltransferase
EW640_RS11450	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
EW640_RS11460	ENOG4105D38	putrescine abc transporter
EW640_RS11470	ENOG4105C84	Histidine ammonia-lyase
EW640_RS11475	ENOG4105Q56	cytochrome P450
EW640_RS11495	ENOG4107VHA	regulatoR
EW640_RS11505	ENOG4105C26	Dehydrogenase
EW640_RS11510	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
EW640_RS11520	ENOG4105CK7	Sodium proline symporter
EW640_RS11565	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
EW640_RS11575	ENOG4105F44	Two component transcriptional regulator, winged helix family
EW640_RS11580	ENOG4106F60	Histidine kinase
EW640_RS11620	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
EW640_RS11635	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
EW640_RS11640	ENOG4105WH1	Two component transcriptional regulator luxr family
EW640_RS11645	ENOG4105BZU	Histidine kinase
EW640_RS11710	ENOG4108KTG	Membrane protein, drug metabolite transporter
EW640_RS11715	ENOG4108RYK	Nad-dependent epimerase dehydratase
EW640_RS11720	ENOG41062A4	Transcriptional regulator
EW640_RS11730	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
EW640_RS11745	ENOG4105RE0	Asp Glu hydantoin racemase
EW640_RS11755	ENOG4105F27	Major Facilitator
EW640_RS11760	ENOG4105E7U	AraC family transcriptional regulator
EW640_RS11790	ENOG4107URF	beta-phospho-glucomutase
EW640_RS11810	ENOG4107RUE	extracellular solute-binding protein family 1
EW640_RS11840	ENOG4105CSH	Transporter
EW640_RS11850	ENOG4107S4Y	M20 DapE family protein YgeY
EW640_RS11860	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
EW640_RS11865	ENOG4105C0D	helicase
EW640_RS11875	ENOG4105F04	LysR family Transcriptional regulator
EW640_RS11885	ENOG4105BZ4	penicillin-binding protein
EW640_RS11935	ENOG41073TP	transcriptional regulator
EW640_RS11940	ENOG4105DAA	L-lactate
EW640_RS11945	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
EW640_RS11955	ENOG41080R8	Conserved Protein
EW640_RS11960	ENOG4105CGP	Urocanate hydratase
EW640_RS11965	ENOG4105CB5	ATP-dependent DNA helicase recG
EW640_RS11985	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
EW640_RS11995	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
EW640_RS12020	ENOG4105CI2	imidazolone-5-propionate hydrolase
EW640_RS12025	ENOG4105C84	Histidine ammonia-lyase
EW640_RS12035	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
EW640_RS12040	ENOG4107HP6	Transcriptional regulator
EW640_RS12045	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
EW640_RS12075	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
EW640_RS12090	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
EW640_RS12095	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
EW640_RS12130	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
EW640_RS12145	ENOG4105CZN	Potassium uptake protein
EW640_RS12150	ENOG4107ZYR	domain protein
EW640_RS12160	ENOG4105BZU	Histidine kinase
EW640_RS12165	ENOG4105WH1	Two component transcriptional regulator luxr family
EW640_RS12170	ENOG4107QMH	DNA methylase
EW640_RS12180	ENOG4105D5U	fad dependent oxidoreductase
EW640_RS12220	ENOG4107R9S	Malate synthase
EW640_RS12230	ENOG4105S6R	Iron-hydroxamate transporter permease subunit
EW640_RS12235	ENOG4108HUF	Transporter
EW640_RS12240	ENOG4105E0A	ABC, transporter
EW640_RS12250	ENOG4105SHT	UspA domain-containing protein
EW640_RS12265	ENOG4105CQB	FAD linked oxidase domain protein
EW640_RS12280	ENOG4105EFZ	amidohydrolase
EW640_RS12290	ENOG4105C5X	domain protein
EW640_RS12295	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EW640_RS12300	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
EW640_RS12310	ENOG4105EJQ	L-serine dehydratase
EW640_RS12325	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
EW640_RS12340	ENOG4105C4B	ABC transporter, permease
EW640_RS12350	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
EW640_RS12370	ENOG4105C7Z	Conserved Protein
EW640_RS12405	ENOG4105DFM	M18 family aminopeptidase
EW640_RS12425	ENOG4105C9K	Endothelin-converting enzyme 1
EW640_RS12435	ENOG4105KJF	protein tyrosine phosphatase
EW640_RS12465	ENOG4105WZW	rhodanese family
EW640_RS12480	ENOG4105W1N	transcriptional regulator
EW640_RS12520	ENOG4105WH1	Two component transcriptional regulator luxr family
EW640_RS12555	ENOG4107QXG	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EW640_RS12565	ENOG4108PYU	two-component system response regulator
EW640_RS12595	ENOG4105F9F	transposase
EW640_RS12600	ENOG4108ZEY	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
EW640_RS12610	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
EW640_RS12615	ENOG4105HDK	L-asparaginase
EW640_RS12640	ENOG4105EWK	phytoene
EW640_RS12660	ENOG4105DPV	During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction
EW640_RS12665	ENOG4105FDP	GntR family transcriptional regulator
EW640_RS12670	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
EW640_RS12695	ENOG4105E90	ABC transporter
EW640_RS12700	ENOG4108IJ8	ABC transporter
EW640_RS12705	ENOG4105E90	ABC transporter
EW640_RS12735	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
EW640_RS12755	ENOG4105CFG	Acts as a chaperone (By similarity)
EW640_RS12760	ENOG4108093	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EW640_RS12765	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
EW640_RS12770	ENOG4105KNI	merR family transcriptional Regulator
EW640_RS12785	ENOG4107QPK	)-transporter
EW640_RS12800	ENOG4107TE5	Lipid kinase
EW640_RS12805	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
EW640_RS12810	ENOG4108X4Q	Hydrolase
EW640_RS12830	ENOG410667J	hydrolase
EW640_RS12840	ENOG4108VC7	Protein of unknown function (DUF2587)
EW640_RS12845	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
EW640_RS12870	ENOG4105CHH	sulfate transporter
EW640_RS12910	ENOG4108M9J	MaoC like domain protein
EW640_RS12915	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
EW640_RS12920	ENOG4108IG5	Transcriptional regulator
EW640_RS12925	ENOG4105EYF	MMPL domain protein
EW640_RS12940	ENOG4108KGH	TRANSCRIPTIONal
EW640_RS12975	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
EW640_RS12985	ENOG4107QN1	sodium solute
EW640_RS13005	ENOG4105C26	Dehydrogenase
EW640_RS13015	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
EW640_RS13025	ENOG4105DWT	malate dehydrogenase (quinone)
EW640_RS13045	ENOG4105EFI	regulatoR
EW640_RS13055	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
EW640_RS13065	ENOG4108Z6B	deaminase
EW640_RS13105	ENOG4107XZA	Glycosyl transferase family 2
EW640_RS13115	ENOG4108RWI	nicotinamidase
EW640_RS13120	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
EW640_RS13130	ENOG4105CIH	Imidazole acetol-phosphate transaminase
EW640_RS13135	ENOG4105CQB	FAD linked oxidase domain protein
EW640_RS13145	ENOG4105ERH	Fumarylacetoacetate hydrolase
EW640_RS13150	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
EW640_RS13165	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
EW640_RS13170	ENOG4105DGW	oligopeptidase A
EW640_RS13175	ENOG4105D94	Major Facilitator Superfamily
EW640_RS13180	ENOG4105C26	Dehydrogenase
EW640_RS13230	ENOG4108W6C	Dehydrogenase
EW640_RS13305	ENOG4108Z0Z	intracellular protease Pfpi family
EW640_RS13375	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
EW640_RS13385	ENOG4105VMP	Transcriptional regulator
EW640_RS13390	ENOG4105CFH	Aspartokinase
EW640_RS13405	ENOG4105DIK	(ABC) transporter
EW640_RS13420	ENOG4105BZ4	penicillin-binding protein
EW640_RS13430	ENOG4105KME	endoribonuclease L-psp
EW640_RS13460	ENOG4105P8F	nudix hydrolase
EW640_RS13470	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
EW640_RS13515	ENOG4108I5C	dEAD DEAH box helicase
EW640_RS13525	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
EW640_RS13540	ENOG4105C6E	dna polymerase iii
EW640_RS13565	ENOG4105CUC	YeeE YedE family protein
EW640_RS13575	ENOG4108YV4	Universal stress protein
EW640_RS13580	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
EW640_RS13600	ENOG4107QX3	carboxylase
EW640_RS13610	ENOG4105C1G	acyl-Coa dehydrogenase
EW640_RS13615	ENOG4107VXZ	Hydrolase
EW640_RS13620	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
EW640_RS13645	ENOG4105CE7	Amidase, hydantoinase carbamoylase family
EW640_RS13655	ENOG4108Z86	Glutamine amidotransferase
EW640_RS13660	ENOG4105C26	Dehydrogenase
EW640_RS13665	ENOG4105CHR	reductase
EW640_RS13675	ENOG4105CH2	amidohydrolase
EW640_RS13685	ENOG4105CK7	Sodium proline symporter
EW640_RS13695	ENOG4107QN1	sodium solute
EW640_RS13715	ENOG4105CEY	Amp-dependent synthetase and ligase
EW640_RS13735	ENOG4108RBJ	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
EW640_RS13745	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
EW640_RS13755	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
EW640_RS13790	ENOG4107RD1	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
EW640_RS13795	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
EW640_RS13800	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
EW640_RS13805	ENOG4105EUJ	GTP cyclohydrolase i
EW640_RS13840	ENOG4105CRK	lysyL-tRNA synthetase
EW640_RS13905	ENOG4105E59	Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity)
EW640_RS13920	ENOG4105C26	Dehydrogenase
EW640_RS13925	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
EW640_RS13930	ENOG4107F9Y	LysR family transcriptional regulator
EW640_RS13935	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
EW640_RS13945	ENOG4108JJB	ABC transporter
EW640_RS13950	ENOG4105NSK	ABC superfamily ATP binding cassette transporter membrane protein
EW640_RS13970	ENOG4105CR4	methylisocitrate lyase
EW640_RS13975	ENOG4105BZN	citrate synthase
EW640_RS13980	ENOG4105E39	Enoyl-CoA hydratase
EW640_RS13990	ENOG4105CIG	ABC transporter
EW640_RS14000	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
EW640_RS14010	ENOG4107R33	ppx gppa phosphatase
EW640_RS14015	ENOG4105EY0	Xylose isomerase domain protein TIM barrel
EW640_RS14020	ENOG4105II7	pyrroline-5-carboxylate reductase
EW640_RS14025	ENOG4105CHH	sulfate transporter
EW640_RS14030	ENOG4107ZYR	domain protein
EW640_RS14035	ENOG4105DGU	Histone deacetylase
EW640_RS14050	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
EW640_RS14055	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
EW640_RS14065	ENOG4105D52	delta-aminolevulinic acid dehydratase
EW640_RS14075	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
EW640_RS14080	ENOG4108RH7	phosphoglycerate mutase
EW640_RS14090	ENOG4107QIV	Cytochrome c biogenesis protein
EW640_RS14095	ENOG4105EBH	Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity)
EW640_RS14100	ENOG4105CRE	cytochrome C
EW640_RS14105	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
EW640_RS14125	ENOG4107SIQ	Naphthoate synthase
EW640_RS14160	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
EW640_RS14175	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
EW640_RS14180	ENOG4105P52	geranylgeranyl reductase
EW640_RS14200	ENOG4108VPT	UPF0234 protein
EW640_RS14245	ENOG4105CSV	Glutaminase
EW640_RS14250	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
EW640_RS14265	ENOG4105CEY	Amp-dependent synthetase and ligase
EW640_RS14285	ENOG410900P	UPF0336 protein
EW640_RS14295	ENOG4107R4N	Cell wall formation (By similarity)
EW640_RS14320	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
EW640_RS14325	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
EW640_RS14330	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
EW640_RS14340	ENOG4108VZM	50s ribosomal protein L10
EW640_RS14345	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
EW640_RS14370	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
EW640_RS14375	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
EW640_RS14385	ENOG4105CTQ	phosphohexokinase
EW640_RS14395	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
EW640_RS14400	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
EW640_RS14405	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
EW640_RS14410	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
EW640_RS14435	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
EW640_RS14440	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
EW640_RS14445	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
EW640_RS14450	ENOG4105KZR	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
EW640_RS14455	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EW640_RS14460	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
EW640_RS14465	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
EW640_RS14470	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
EW640_RS14475	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
EW640_RS14480	ENOG41082SA	50s ribosomal protein l29
EW640_RS14485	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
EW640_RS14490	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
EW640_RS14495	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
EW640_RS14500	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EW640_RS14505	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
EW640_RS14510	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
EW640_RS14515	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
EW640_RS14520	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
EW640_RS14525	ENOG410849U	50S ribosomal protein L30
EW640_RS14530	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
EW640_RS14535	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
EW640_RS14540	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
EW640_RS14545	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
EW640_RS14560	ENOG4105C87	Aminotransferase class I and II
EW640_RS14575	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
EW640_RS14580	ENOG41067V7	50S ribosomal protein L36
EW640_RS14585	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EW640_RS14590	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
EW640_RS14595	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
EW640_RS14600	ENOG4108ZT0	50S ribosomal protein l17
EW640_RS14635	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
EW640_RS14640	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)