locus-tag	class	description
EW640_RS00005	COG0488	(ABC) transporter
EW640_RS00015	COG1966	Carbon starvation protein
EW640_RS00020	COG0180	Tryptophanyl-tRNA synthetase
EW640_RS00045	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EW640_RS00060	COG2009	succinate dehydrogenase
EW640_RS00070	COG1473	amidohydrolase
EW640_RS00070	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EW640_RS00080	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EW640_RS00100	COG1846	Transcriptional regulator
EW640_RS00105	COG0045	succinate-CoA ligase (ADP-forming) activity
EW640_RS00120	COG0589	response to stress
EW640_RS00160	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EW640_RS00220	COG2239	Acts as a magnesium transporter
EW640_RS00230	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EW640_RS00265	COG0482	sulfurtransferase activity
EW640_RS00285	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EW640_RS00295	COG4122	O-methyltransferase activity
EW640_RS00300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EW640_RS00315	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EW640_RS00320	COG0154	amidase activity
EW640_RS00325	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EW640_RS00335	COG0242	peptide deformylase activity
EW640_RS00345	COG1045	serine acetyltransferase
EW640_RS00365	COG0129	dihydroxy-acid dehydratase activity
EW640_RS00395	COG1132	(ABC) transporter
EW640_RS00400	COG1132	(ABC) transporter
EW640_RS00425	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EW640_RS00430	COG4552	Acetyltransferase involved in intracellular survival and related
EW640_RS00435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EW640_RS00445	COG0473	3-isopropylmalate dehydrogenase activity
EW640_RS00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EW640_RS00455	COG0477	Major facilitator Superfamily
EW640_RS00460	COG0095	Lipoate-protein ligase
EW640_RS00485	COG1643	Atp-dependent helicase
EW640_RS00500	COG0549	Belongs to the carbamate kinase family
EW640_RS00510	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EW640_RS00525	COG1304	FMN binding
EW640_RS00540	COG2233	PERMEase
EW640_RS00570	COG0179	Fumarylacetoacetate (FAA) hydrolase
EW640_RS00575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EW640_RS00585	COG1028	Short-chain dehydrogenase reductase Sdr
EW640_RS00610	COG1414	Transcriptional regulator
EW640_RS00615	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EW640_RS00620	COG0066	3-isopropylmalate dehydratase activity
EW640_RS00625	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EW640_RS00635	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EW640_RS00645	COG1181	Belongs to the D-alanine--D-alanine ligase family
EW640_RS00660	COG1461	Dihydroxyacetone kinase
EW640_RS00670	COG0742	ribosomal rna small subunit methyltransferase
EW640_RS00675	COG1126	abc transporter atp-binding protein
EW640_RS00680	COG0765	amino acid transport
EW640_RS00690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EW640_RS00695	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EW640_RS00705	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EW640_RS00710	COG0571	ribonuclease III activity
EW640_RS00720	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EW640_RS00730	COG2031	fatty acid transporter
EW640_RS00740	COG4115	mRNA cleavage
EW640_RS00750	COG1196	nuclear chromosome segregation
EW640_RS00770	COG0228	four-way junction DNA binding
EW640_RS00775	COG1837	Belongs to the UPF0109 family
EW640_RS00785	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EW640_RS00790	COG0336	Belongs to the RNA methyltransferase TrmD family
EW640_RS00795	COG0335	large ribosomal subunit rRNA binding
EW640_RS00805	COG0681	Belongs to the peptidase S26 family
EW640_RS00810	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EW640_RS00820	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EW640_RS00830	COG2161	toxin-antitoxin pair type II binding
EW640_RS00835	COG0792	nuclease activity
EW640_RS00860	COG0702	epimerase
EW640_RS00870	COG0052	Belongs to the universal ribosomal protein uS2 family
EW640_RS00875	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EW640_RS00880	COG0528	UMP kinase activity
EW640_RS00885	COG0233	cytoplasmic translational termination
EW640_RS00890	COG0575	Belongs to the CDS family
EW640_RS00895	COG0277	FAD linked oxidase domain protein
EW640_RS00910	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EW640_RS00935	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EW640_RS00940	COG0750	zinc metalloprotease
EW640_RS00950	COG2358	TRAP transporter, solute receptor (TAXI family
EW640_RS00960	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EW640_RS00975	COG1028	Short-chain dehydrogenase reductase Sdr
EW640_RS00980	COG0442	prolyl-tRNA aminoacylation
EW640_RS00995	COG0431	NADPH-dependent FMN reductase
EW640_RS01015	COG0779	Required for maturation of 30S ribosomal subunits
EW640_RS01030	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EW640_RS01035	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EW640_RS01050	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EW640_RS01060	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EW640_RS01065	COG1185	polyribonucleotide nucleotidyltransferase activity
EW640_RS01070	COG0612	Peptidase, M16
EW640_RS01090	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EW640_RS01110	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EW640_RS01115	COG1674	ftsk spoiiie
EW640_RS01130	COG1546	Belongs to the CinA family
EW640_RS01130	COG1058	Belongs to the CinA family
EW640_RS01135	COG1396	sequence-specific DNA binding
EW640_RS01145	COG0456	acetyltransferase
EW640_RS01150	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EW640_RS01155	COG2137	regulation of response to DNA damage stimulus
EW640_RS01165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EW640_RS01170	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EW640_RS01175	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EW640_RS01185	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EW640_RS01195	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EW640_RS01205	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EW640_RS01210	COG0131	Imidazoleglycerol-phosphate dehydratase
EW640_RS01220	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EW640_RS01225	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EW640_RS01250	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EW640_RS01265	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EW640_RS01270	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EW640_RS01275	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EW640_RS01280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EW640_RS01290	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EW640_RS01295	COG0477	Major facilitator Superfamily
EW640_RS01305	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EW640_RS01310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EW640_RS01310	COG0072	phenylalanine-tRNA ligase activity
EW640_RS01320	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EW640_RS01325	COG0542	response to heat
EW640_RS01335	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EW640_RS01350	COG0438	transferase activity, transferring glycosyl groups
EW640_RS01360	COG1086	Polysaccharide biosynthesis protein
EW640_RS01365	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EW640_RS01370	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EW640_RS01380	COG1216	Glycosyl transferase, family 2
EW640_RS01395	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EW640_RS01400	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EW640_RS01405	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EW640_RS01415	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EW640_RS01420	COG1438	arginine binding
EW640_RS01425	COG0137	argininosuccinate synthase activity
EW640_RS01430	COG0165	Argininosuccinate lyase
EW640_RS01440	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EW640_RS01475	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EW640_RS01495	COG0647	UMP catabolic process
EW640_RS01510	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EW640_RS01550	COG0504	CTP synthase activity
EW640_RS01570	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EW640_RS01575	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EW640_RS01590	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EW640_RS01595	COG1160	GTP binding
EW640_RS01600	COG0628	permease
EW640_RS01610	COG0009	L-threonylcarbamoyladenylate synthase
EW640_RS01620	COG0318	PFAM AMP-dependent synthetase and ligase
EW640_RS01635	COG1028	Short-chain dehydrogenase reductase Sdr
EW640_RS01640	COG1960	acyl-CoA dehydrogenase activity
EW640_RS01645	COG1960	acyl-CoA dehydrogenase activity
EW640_RS01650	COG0183	Belongs to the thiolase family
EW640_RS01655	COG0318	PFAM AMP-dependent synthetase and ligase
EW640_RS01660	COG0534	Mate efflux family protein
EW640_RS01695	COG1074	ATP-dependent DNA helicase activity
EW640_RS01715	COG2814	Major facilitator Superfamily
EW640_RS01750	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EW640_RS01785	COG1028	Short-chain dehydrogenase reductase Sdr
EW640_RS01855	COG0509	glycine decarboxylation via glycine cleavage system
EW640_RS01870	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
EW640_RS01880	COG0515	serine threonine protein kinase
EW640_RS01880	COG2815	serine threonine protein kinase
EW640_RS01885	COG1388	LysM domain
EW640_RS01885	COG0741	lytic transglycosylase activity
EW640_RS01905	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EW640_RS01925	COG0714	Associated with various cellular activities
EW640_RS01930	COG2001	Belongs to the MraZ family
EW640_RS01935	COG0275	rRNA processing
EW640_RS01945	COG0768	penicillin binding
EW640_RS01950	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EW640_RS01955	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EW640_RS01960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EW640_RS01965	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EW640_RS01975	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EW640_RS01980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EW640_RS01990	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EW640_RS02000	COG1799	cell septum assembly
EW640_RS02015	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EW640_RS02025	COG0587	DNA-directed DNA polymerase activity
EW640_RS02035	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EW640_RS02055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EW640_RS02060	COG0860	N-Acetylmuramoyl-L-alanine amidase
EW640_RS02065	COG0187	DNA topoisomerase II activity
EW640_RS02085	COG1294	oxidase, subunit
EW640_RS02090	COG4988	ABC transporter
EW640_RS02120	COG0756	dUTP diphosphatase activity
EW640_RS02140	COG0569	domain protein
EW640_RS02145	COG0531	amino acid
EW640_RS02150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EW640_RS02155	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EW640_RS02160	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EW640_RS02190	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EW640_RS02205	COG2153	protein acetylation
EW640_RS02210	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EW640_RS02220	COG0039	L-malate dehydrogenase activity
EW640_RS02240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EW640_RS02250	COG1381	Involved in DNA repair and RecF pathway recombination
EW640_RS02255	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EW640_RS02280	COG0423	glycine-tRNA ligase activity
EW640_RS02305	COG0477	Major facilitator Superfamily
EW640_RS02320	COG0358	DNA primase activity
EW640_RS02325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EW640_RS02345	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EW640_RS02365	COG2094	Belongs to the DNA glycosylase MPG family
EW640_RS02370	COG1295	ribonuclease BN
EW640_RS02375	COG2326	polyphosphate kinase activity
EW640_RS02380	COG1022	Amp-dependent synthetase and ligase
EW640_RS02385	COG0495	leucyl-tRNA aminoacylation
EW640_RS02390	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EW640_RS02400	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EW640_RS02405	COG1307	EDD domain protein, DegV family
EW640_RS02410	COG1555	photosystem II stabilization
EW640_RS02425	COG0268	Binds directly to 16S ribosomal RNA
EW640_RS02440	COG0481	GTPase activity
EW640_RS02465	COG1420	regulation of RNA biosynthetic process
EW640_RS02470	COG0484	heat shock protein binding
EW640_RS02475	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EW640_RS02480	COG1702	phosphate starvation-inducible protein PhoH
EW640_RS02485	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EW640_RS02495	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EW640_RS02500	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EW640_RS02505	COG2326	polyphosphate kinase activity
EW640_RS02540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EW640_RS02550	COG0823	Involved in the tonB-independent uptake of proteins
EW640_RS02550	COG4946	Tricorn protease homolog
EW640_RS02550	COG1506	peptidase
EW640_RS02560	COG0217	transcriptional regulatory protein
EW640_RS02565	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EW640_RS02570	COG0632	four-way junction helicase activity
EW640_RS02575	COG2255	four-way junction helicase activity
EW640_RS02585	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EW640_RS02590	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EW640_RS02595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EW640_RS02605	COG1196	nuclear chromosome segregation
EW640_RS02615	COG0124	histidyl-tRNA synthetase
EW640_RS02620	COG0640	Transcriptional regulator
EW640_RS02625	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EW640_RS02635	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EW640_RS02640	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EW640_RS02645	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EW640_RS02650	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EW640_RS02655	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EW640_RS02665	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EW640_RS02670	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EW640_RS02675	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EW640_RS02680	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EW640_RS02685	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EW640_RS02690	COG0596	Alpha beta hydrolase
EW640_RS02695	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EW640_RS02700	COG0540	Belongs to the ATCase OTCase family
EW640_RS02705	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EW640_RS02715	COG0505	Belongs to the CarA family
EW640_RS02720	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EW640_RS02725	COG0284	orotidine-5'-phosphate decarboxylase activity
EW640_RS02730	COG0194	GDP metabolic process
EW640_RS02735	COG0194	GDP metabolic process
EW640_RS02740	COG1758	RNA polymerase activity
EW640_RS02750	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EW640_RS02760	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EW640_RS02770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EW640_RS02775	COG3201	nicotinamide mononucleotide transporter
EW640_RS02785	COG2197	response regulator
EW640_RS02790	COG1131	(ABC) transporter
EW640_RS02800	COG0140	phosphoribosyl-ATP diphosphatase activity
EW640_RS02805	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EW640_RS02825	COG0107	imidazoleglycerol-phosphate synthase activity
EW640_RS02830	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EW640_RS02835	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EW640_RS02850	COG0134	indole-3-glycerol-phosphate synthase activity
EW640_RS02855	COG0133	tryptophan synthase activity
EW640_RS02860	COG0159	tryptophan synthase activity
EW640_RS02865	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EW640_RS02870	COG0469	pyruvate kinase activity
EW640_RS02875	COG1950	PFAM Membrane protein of
EW640_RS02890	COG2050	protein possibly involved in aromatic compounds catabolism
EW640_RS02930	COG2801	Transposase and inactivated derivatives
EW640_RS03025	COG2050	protein possibly involved in aromatic compounds catabolism
EW640_RS03035	COG2226	methyltransferase
EW640_RS03040	COG0539	negative regulation of cytoplasmic translation
EW640_RS03050	COG0237	dephospho-CoA kinase activity
EW640_RS03050	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EW640_RS03055	COG1764	response to oxidative stress
EW640_RS03060	COG0556	nucleotide-excision repair
EW640_RS03085	COG0322	excinuclease ABC activity
EW640_RS03090	COG1660	Displays ATPase and GTPase activities
EW640_RS03095	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EW640_RS03100	COG1481	regulation of sporulation
EW640_RS03105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EW640_RS03110	COG0126	phosphoglycerate kinase activity
EW640_RS03115	COG0149	triose-phosphate isomerase activity
EW640_RS03120	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EW640_RS03125	COG0166	Belongs to the GPI family
EW640_RS03130	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EW640_RS03140	COG0109	protoheme IX farnesyltransferase activity
EW640_RS03170	COG0719	Fe-S assembly protein
EW640_RS03175	COG0719	Fe-S assembly protein
EW640_RS03185	COG0396	ATPase activity
EW640_RS03195	COG0822	iron-sulfur transferase activity
EW640_RS03200	COG2151	metal-sulfur cluster biosynthetic enzyme
EW640_RS03210	COG0328	RNA-DNA hybrid ribonuclease activity
EW640_RS03215	COG0488	(ABC) transporter
EW640_RS03235	COG1028	Short-chain dehydrogenase reductase Sdr
EW640_RS03240	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EW640_RS03250	COG0560	Phosphoserine phosphatase
EW640_RS03250	COG3830	Belongs to the UPF0237 family
EW640_RS03260	COG1119	ATPase activity
EW640_RS03270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EW640_RS03290	COG0254	rRNA binding
EW640_RS03295	COG0351	phosphomethylpyrimidine kinase
EW640_RS03300	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EW640_RS03315	COG0587	DNA-directed DNA polymerase activity
EW640_RS03320	COG2873	o-acetylhomoserine
EW640_RS03325	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EW640_RS03330	COG1960	acyl-CoA dehydrogenase activity
EW640_RS03340	COG0183	Belongs to the thiolase family
EW640_RS03350	COG2030	dehydratase
EW640_RS03390	COG0406	alpha-ribazole phosphatase activity
EW640_RS03395	COG1968	undecaprenyl-diphosphatase activity
EW640_RS03400	COG0667	Aldo Keto reductase
EW640_RS03420	COG0215	cysteine-tRNA ligase activity
EW640_RS03430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EW640_RS03450	COG1222	aaa ATPase
EW640_RS03460	COG4122	O-methyltransferase activity
EW640_RS03470	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
EW640_RS03475	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
EW640_RS03510	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EW640_RS03515	COG0805	protein transport
EW640_RS03525	COG0653	protein targeting
EW640_RS03530	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EW640_RS03540	COG0463	Glycosyl transferase, family 2
EW640_RS03550	COG0584	glycerophosphoryl diester phosphodiesterase
EW640_RS03560	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EW640_RS03580	COG0726	polysaccharide deacetylase
EW640_RS03595	COG0604	alcohol dehydrogenase
EW640_RS03625	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EW640_RS03630	COG0420	3'-5' exonuclease activity
EW640_RS03635	COG0419	ATPase involved in DNA repair
EW640_RS03640	COG1192	Involved in chromosome partitioning
EW640_RS03650	COG0204	Acyl-transferase
EW640_RS03675	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EW640_RS03680	COG1845	cytochrome c oxidase, subunit III
EW640_RS03685	COG2010	Cytochrome c
EW640_RS03690	COG0723	plastoquinol--plastocyanin reductase activity
EW640_RS03695	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EW640_RS03705	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EW640_RS03710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EW640_RS03715	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EW640_RS03725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EW640_RS03735	COG0167	dihydroorotate dehydrogenase activity
EW640_RS03740	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EW640_RS03745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EW640_RS03750	COG0508	dehydrogenase complex catalyzes the overall conversion of
EW640_RS03760	COG0321	lipoyl(octanoyl) transferase activity
EW640_RS03765	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EW640_RS03790	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EW640_RS03795	COG0174	glutamine synthetase
EW640_RS03805	COG0686	Belongs to the AlaDH PNT family
EW640_RS03815	COG1940	carbohydrate kinase activity
EW640_RS03820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EW640_RS03825	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EW640_RS03830	COG0156	8-amino-7-oxononanoate synthase activity
EW640_RS03835	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EW640_RS03850	COG3022	response to hydroperoxide
EW640_RS03860	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EW640_RS03865	COG0318	PFAM AMP-dependent synthetase and ligase
EW640_RS03920	COG1280	lysine exporter protein (LysE YggA)
EW640_RS03925	COG0477	Major facilitator Superfamily
EW640_RS03940	COG1028	Short-chain dehydrogenase reductase Sdr
EW640_RS03945	COG0655	NAD(P)H dehydrogenase (quinone) activity
EW640_RS03960	COG2076	Multidrug Resistance protein
EW640_RS03965	COG2076	Multidrug Resistance protein
EW640_RS03985	COG1819	glycosyl
EW640_RS04005	COG1131	(ABC) transporter
EW640_RS04025	COG1414	Transcriptional regulator
EW640_RS04045	COG2818	Glycosylase
EW640_RS04050	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EW640_RS04075	COG1309	transcriptional regulator
EW640_RS04095	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EW640_RS04110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EW640_RS04115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EW640_RS04135	COG3559	Exporter of polyketide antibiotics
EW640_RS04140	COG1131	(ABC) transporter
EW640_RS04145	COG1309	transcriptional regulator
EW640_RS04165	COG0477	Major facilitator Superfamily
EW640_RS04170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EW640_RS04175	COG0438	transferase activity, transferring glycosyl groups
EW640_RS04205	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EW640_RS04215	COG0028	Belongs to the TPP enzyme family
EW640_RS04290	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EW640_RS04305	COG2801	Transposase and inactivated derivatives
EW640_RS04305	COG3415	Transposase
EW640_RS04310	COG1917	Cupin 2, conserved barrel domain protein
EW640_RS04310	COG4977	sequence-specific DNA binding
EW640_RS04320	COG1937	Protein conserved in bacteria
EW640_RS04325	COG2217	Heavy metal translocating P-type atpase
EW640_RS04355	COG0477	Major facilitator Superfamily
EW640_RS04365	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EW640_RS04420	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EW640_RS04420	COG2111	Na H antiporter
EW640_RS04430	COG0588	phosphoglycerate mutase activity
EW640_RS04435	COG0799	negative regulation of ribosome biogenesis
EW640_RS04445	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EW640_RS04455	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EW640_RS04460	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EW640_RS04465	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EW640_RS04470	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EW640_RS04475	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EW640_RS04480	COG1605	Chorismate mutase
EW640_RS04480	COG0287	Prephenate dehydrogenase
EW640_RS04490	COG1115	amino acid carrier protein
EW640_RS04495	COG1530	ribonuclease E activity
EW640_RS04515	COG0285	dihydrofolate synthase activity
EW640_RS04540	COG0525	valine-tRNA ligase activity
EW640_RS04550	COG0640	Transcriptional regulator
EW640_RS04560	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EW640_RS04565	COG0740	serine-type endopeptidase activity
EW640_RS04575	COG0544	peptidyl-prolyl cis-trans isomerase activity
EW640_RS04625	COG0698	ribose 5-phosphate isomerase
EW640_RS04630	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EW640_RS04640	COG0668	transmembrane transport
EW640_RS04660	COG1946	Acyl-CoA thioesterase
EW640_RS04700	COG0183	Belongs to the thiolase family
EW640_RS04715	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
EW640_RS04730	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EW640_RS04735	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EW640_RS04740	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EW640_RS04745	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EW640_RS04750	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EW640_RS04755	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EW640_RS04760	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EW640_RS04765	COG0356	it plays a direct role in the translocation of protons across the membrane
EW640_RS04775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EW640_RS04780	COG0009	L-threonylcarbamoyladenylate synthase
EW640_RS04790	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EW640_RS04800	COG0083	homoserine kinase activity
EW640_RS04805	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EW640_RS04810	COG0460	homoserine dehydrogenase
EW640_RS04820	COG0018	arginyl-trna synthetase
EW640_RS04920	COG0567	Dehydrogenase, E1 component
EW640_RS04920	COG0508	dehydrogenase complex catalyzes the overall conversion of
EW640_RS04935	COG1595	DNA-templated transcription, initiation
EW640_RS04940	COG1278	Cold shock
EW640_RS04955	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EW640_RS04965	COG0483	inositol monophosphate 1-phosphatase activity
EW640_RS04975	COG2807	transmembrane transport
EW640_RS04985	COG1615	UPF0182 protein
EW640_RS04990	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EW640_RS05040	COG1309	transcriptional regulator
EW640_RS05060	COG0613	PHP domain protein
EW640_RS05065	COG0006	proline dipeptidase activity
EW640_RS05120	COG1611	Belongs to the LOG family
EW640_RS05125	COG2171	N-acyltransferase activity
EW640_RS05165	COG2720	vancomycin resistance protein
EW640_RS05170	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EW640_RS05180	COG2197	response regulator
EW640_RS05210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EW640_RS05235	COG2076	Multidrug Resistance protein
EW640_RS05245	COG1902	pentaerythritol trinitrate reductase activity
EW640_RS05250	COG0471	metal ion transport
EW640_RS05255	COG2267	carboxylic ester hydrolase activity
EW640_RS05260	COG1435	thymidine kinase activity
EW640_RS05265	COG2838	Isocitrate dehydrogenase
EW640_RS05290	COG1765	OsmC-like protein
EW640_RS05295	COG3104	oligopeptide transport
EW640_RS05300	COG2354	Protein conserved in bacteria
EW640_RS05310	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EW640_RS05320	COG1063	alcohol dehydrogenase
EW640_RS05340	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EW640_RS05345	COG0450	alkyl hydroperoxide reductase
EW640_RS05375	COG3012	SEC-C Motif Domain Protein
EW640_RS05390	COG0596	Alpha beta hydrolase
EW640_RS05405	COG1285	pathogenesis
EW640_RS05420	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EW640_RS05465	COG0433	COG0433 Predicted ATPase
EW640_RS05500	COG3285	dna ligase
EW640_RS05500	COG1793	dna ligase
EW640_RS05505	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
EW640_RS05520	COG2801	Transposase and inactivated derivatives
EW640_RS05520	COG3415	Transposase
EW640_RS05525	COG2267	carboxylic ester hydrolase activity
EW640_RS05610	COG0259	pyridoxamine-phosphate oxidase activity
EW640_RS05625	COG0012	GTP binding
EW640_RS05630	COG1322	Protein conserved in bacteria
EW640_RS05640	COG0515	serine threonine protein kinase
EW640_RS05645	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EW640_RS05650	COG1570	exodeoxyribonuclease VII activity
EW640_RS05655	COG1722	exodeoxyribonuclease VII activity
EW640_RS05665	COG1494	fructose-1,6-bisphosphatase
EW640_RS05670	COG0288	reversible hydration of carbon dioxide
EW640_RS05675	COG0114	fumarate hydratase activity
EW640_RS05680	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EW640_RS05685	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EW640_RS05700	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EW640_RS05710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EW640_RS05725	COG0402	S-adenosylhomocysteine deaminase activity
EW640_RS05730	COG0477	Major facilitator Superfamily
EW640_RS05735	COG2755	lipolytic protein G-D-S-L family
EW640_RS05740	COG0424	maF-like protein
EW640_RS05745	COG4770	biotin carboxylase activity
EW640_RS05775	COG2902	Dehydrogenase
EW640_RS05820	COG0653	protein targeting
EW640_RS05825	COG3214	Protein conserved in bacteria
EW640_RS05830	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EW640_RS05845	COG5002	protein histidine kinase activity
EW640_RS05845	COG5000	phosphorelay sensor kinase activity
EW640_RS05850	COG0745	RESPONSE REGULATOR receiver
EW640_RS05870	COG0714	Associated with various cellular activities
EW640_RS05930	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
EW640_RS05930	COG0778	Nitroreductase
EW640_RS05955	COG1482	cell wall glycoprotein biosynthetic process
EW640_RS05965	COG1316	TRANSCRIPTIONal
EW640_RS06020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EW640_RS06020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EW640_RS06025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EW640_RS06055	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EW640_RS06070	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EW640_RS06085	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EW640_RS06100	COG0431	NADPH-dependent FMN reductase
EW640_RS06105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EW640_RS06120	COG3835	regulator
EW640_RS06130	COG2271	Major facilitator Superfamily
EW640_RS06140	COG2814	Major facilitator Superfamily
EW640_RS06150	COG2814	Major facilitator Superfamily
EW640_RS06160	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EW640_RS06165	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EW640_RS06200	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EW640_RS06210	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EW640_RS06220	COG1643	Atp-dependent helicase
EW640_RS06240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EW640_RS06280	COG1252	NADH dehydrogenase
EW640_RS06285	COG1404	Belongs to the peptidase S8 family
EW640_RS06305	COG0148	phosphopyruvate hydratase activity
EW640_RS06315	COG3956	TIGRFAM MazG family protein
EW640_RS06330	COG0193	aminoacyl-tRNA hydrolase activity
EW640_RS06335	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EW640_RS06345	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EW640_RS06375	COG0138	bifunctional purine biosynthesis protein purh
EW640_RS06410	COG0842	Transport permease protein
EW640_RS06435	COG0747	negative chemotaxis
EW640_RS06445	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EW640_RS06450	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EW640_RS06455	COG1234	tRNA 3'-trailer cleavage
EW640_RS06465	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EW640_RS06490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EW640_RS06525	COG2135	peptidase activity
EW640_RS06540	COG1960	acyl-CoA dehydrogenase activity
EW640_RS06545	COG1024	Enoyl-CoA hydratase
EW640_RS06560	COG1024	Enoyl-CoA hydratase
EW640_RS06575	COG0523	cobalamin synthesis protein
EW640_RS06590	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EW640_RS06595	COG1780	Probably involved in ribonucleotide reductase function
EW640_RS06605	COG0714	Associated with various cellular activities
EW640_RS06655	COG0519	Catalyzes the synthesis of GMP from XMP
EW640_RS06655	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EW640_RS06670	COG1619	proteins homologs of microcin C7 resistance protein MccF
EW640_RS06680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EW640_RS06685	COG0601	transmembrane transport
EW640_RS06705	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EW640_RS06725	COG2884	Cell division ATP-binding protein ftsE
EW640_RS06730	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EW640_RS06800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EW640_RS06805	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EW640_RS06845	COG0488	(ABC) transporter
EW640_RS06860	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EW640_RS06865	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EW640_RS06890	COG1472	Belongs to the glycosyl hydrolase 3 family
EW640_RS06895	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EW640_RS06905	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EW640_RS06915	COG0456	acetyltransferase
EW640_RS06925	COG0802	atpase or kinase
EW640_RS06930	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EW640_RS06935	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EW640_RS06935	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EW640_RS06940	COG1473	amidohydrolase
EW640_RS06950	COG0736	holo-[acyl-carrier-protein] synthase activity
EW640_RS06955	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EW640_RS06970	COG0531	amino acid
EW640_RS06975	COG1072	(Pantothenic acid kinase))
EW640_RS06980	COG1132	(ABC) transporter
EW640_RS06985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EW640_RS07020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EW640_RS07025	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EW640_RS07030	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EW640_RS07050	COG0101	tRNA pseudouridine synthase activity
EW640_RS07060	COG0438	transferase activity, transferring glycosyl groups
EW640_RS07065	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EW640_RS07070	COG1122	ATPase activity
EW640_RS07075	COG1268	BioY protein
EW640_RS07080	COG0519	Catalyzes the synthesis of GMP from XMP
EW640_RS07080	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EW640_RS07095	COG0516	GMP reductase activity
EW640_RS07100	COG2318	DinB family
EW640_RS07125	COG0583	DNA-binding transcription factor activity
EW640_RS07140	COG0351	phosphomethylpyrimidine kinase
EW640_RS07140	COG0352	thiamine-phosphate diphosphorylase activity
EW640_RS07140	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EW640_RS07145	COG0351	phosphomethylpyrimidine kinase
EW640_RS07150	COG0352	thiamine-phosphate diphosphorylase activity
EW640_RS07165	COG1946	Acyl-CoA thioesterase
EW640_RS07170	COG0803	Belongs to the bacterial solute-binding protein 9 family
EW640_RS07175	COG1121	(ABC) transporter
EW640_RS07180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EW640_RS07185	COG1321	iron dependent repressor
EW640_RS07195	COG1609	Transcriptional regulator
EW640_RS07200	COG2423	ornithine cyclodeaminase activity
EW640_RS07205	COG1126	abc transporter atp-binding protein
EW640_RS07210	COG0765	amino acid transport
EW640_RS07215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EW640_RS07220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EW640_RS07250	COG0459	protein refolding
EW640_RS07255	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EW640_RS07275	COG0084	hydrolase, TatD family'
EW640_RS07310	COG1083	cytidylyl-transferase
EW640_RS07315	COG2089	acid synthase
EW640_RS07320	COG1216	Glycosyl transferase, family 2
EW640_RS07350	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EW640_RS07355	COG2011	ABC-type metal ion transport system permease component
EW640_RS07360	COG1464	Belongs to the NlpA lipoprotein family
EW640_RS07365	COG2759	Belongs to the formate--tetrahydrofolate ligase family
EW640_RS07385	COG0438	transferase activity, transferring glycosyl groups
EW640_RS07400	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EW640_RS07405	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EW640_RS07420	COG0667	Aldo Keto reductase
EW640_RS07440	COG2031	fatty acid transporter
EW640_RS07450	COG1012	belongs to the aldehyde dehydrogenase family
EW640_RS07460	COG1250	3-hydroxyacyl-CoA dehydrogenase
EW640_RS07470	COG0318	PFAM AMP-dependent synthetase and ligase
EW640_RS07475	COG1024	Enoyl-CoA hydratase
EW640_RS07490	COG0183	Belongs to the thiolase family
EW640_RS07495	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EW640_RS07505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EW640_RS07520	COG2855	membrane
EW640_RS07600	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EW640_RS07615	COG1970	mechanosensitive ion channel activity
EW640_RS07630	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EW640_RS07640	COG0514	ATP-dependent DNA helicase (RecQ)
EW640_RS07645	COG1132	(ABC) transporter
EW640_RS07650	COG1132	(ABC) transporter
EW640_RS07675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EW640_RS07685	COG2326	polyphosphate kinase activity
EW640_RS07725	COG1012	belongs to the aldehyde dehydrogenase family
EW640_RS07730	COG0259	pyridoxamine-phosphate oxidase activity
EW640_RS07755	COG1278	Cold shock
EW640_RS07770	COG1061	Type III restriction enzyme res subunit
EW640_RS07790	COG0069	glutamate synthase activity
EW640_RS07795	COG0745	RESPONSE REGULATOR receiver
EW640_RS07800	COG2205	protein histidine kinase activity
EW640_RS07810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EW640_RS07830	COG0501	Belongs to the peptidase M48B family
EW640_RS07855	COG0459	protein refolding
EW640_RS07860	COG1278	Cold shock
EW640_RS07885	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EW640_RS07895	COG1228	amidohydrolase
EW640_RS07900	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EW640_RS07905	COG2252	PERMEase
EW640_RS07910	COG1396	sequence-specific DNA binding
EW640_RS07940	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EW640_RS07945	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EW640_RS07950	COG2353	YceI-like domain
EW640_RS07960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EW640_RS07965	COG0363	glucosamine-6-phosphate deaminase activity
EW640_RS07985	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EW640_RS07985	COG0515	serine threonine protein kinase
EW640_RS07990	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
EW640_RS08000	COG1609	Transcriptional regulator
EW640_RS08010	COG1028	Short-chain dehydrogenase reductase Sdr
EW640_RS08025	COG0215	cysteine-tRNA ligase activity
EW640_RS08040	COG0733	neurotransmitter:sodium symporter activity
EW640_RS08055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EW640_RS08070	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EW640_RS08075	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EW640_RS08095	COG5002	protein histidine kinase activity
EW640_RS08110	COG0588	phosphoglycerate mutase activity
EW640_RS08120	COG3409	Peptidoglycan-binding domain 1 protein
EW640_RS08125	COG2135	peptidase activity
EW640_RS08140	COG0297	glycogen (starch) synthase activity
EW640_RS08180	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EW640_RS08185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EW640_RS08190	COG0385	Bile acid
EW640_RS08195	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EW640_RS08255	COG0354	folic acid binding
EW640_RS08265	COG4044	May play a role in the intracellular transport of hydrophobic ligands
EW640_RS08275	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EW640_RS08305	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EW640_RS08345	COG2378	regulation of single-species biofilm formation
EW640_RS08350	COG1028	Short-chain dehydrogenase reductase Sdr
EW640_RS08410	COG2186	Transcriptional regulator
EW640_RS08415	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EW640_RS08430	COG0028	Belongs to the TPP enzyme family
EW640_RS08450	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EW640_RS08460	COG4770	biotin carboxylase activity
EW640_RS08470	COG4336	lyase activity
EW640_RS08475	COG1914	H( )-stimulated, divalent metal cation uptake system
EW640_RS08485	COG3226	Transcriptional regulator
EW640_RS08490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EW640_RS08495	COG0765	amino acid transport
EW640_RS08505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EW640_RS08520	COG0477	Major facilitator Superfamily
EW640_RS08530	COG0028	Belongs to the TPP enzyme family
EW640_RS08540	COG1739	Uncharacterized protein family UPF0029
EW640_RS08545	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EW640_RS08585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EW640_RS08620	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EW640_RS08650	COG0626	cystathionine gamma-synthase activity
EW640_RS08670	COG0151	Belongs to the GarS family
EW640_RS08675	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EW640_RS08685	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EW640_RS08690	COG0047	phosphoribosylformylglycinamidine synthase activity
EW640_RS08725	COG3177	Filamentation induced by cAMP protein fic
EW640_RS08730	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EW640_RS08740	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EW640_RS08750	COG2409	Drug exporters of the RND superfamily
EW640_RS08780	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EW640_RS08800	COG1388	LysM domain
EW640_RS08800	COG1134	teichoic acid transport
EW640_RS08810	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EW640_RS08825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EW640_RS08830	COG0601	transmembrane transport
EW640_RS08840	COG1115	amino acid carrier protein
EW640_RS08850	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
EW640_RS08865	COG4145	pantothenate transmembrane transporter activity
EW640_RS08870	COG1609	Transcriptional regulator
EW640_RS08880	COG1316	TRANSCRIPTIONal
EW640_RS08900	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EW640_RS08905	COG3739	integral membrane protein
EW640_RS08920	COG1960	acyl-CoA dehydrogenase activity
EW640_RS08925	COG1960	acyl-CoA dehydrogenase activity
EW640_RS08965	COG4152	abc transporter atp-binding protein
EW640_RS08970	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EW640_RS08985	COG0277	FAD linked oxidase domain protein
EW640_RS09000	COG0542	response to heat
EW640_RS09005	COG1569	PIN domain
EW640_RS09010	COG3311	Transcriptional regulator
EW640_RS09015	COG1024	Enoyl-CoA hydratase
EW640_RS09035	COG2235	arginine
EW640_RS09045	COG1215	transferase activity, transferring glycosyl groups
EW640_RS09060	COG3311	Transcriptional regulator
EW640_RS09065	COG1569	PIN domain
EW640_RS09080	COG2814	Major facilitator Superfamily
EW640_RS09130	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EW640_RS09155	COG0671	phosphoesterase, PA-phosphatase related
EW640_RS09165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EW640_RS09175	COG0183	Belongs to the thiolase family
EW640_RS09180	COG2086	electron transfer activity
EW640_RS09205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EW640_RS09225	COG0857	belongs to the CobB CobQ family
EW640_RS09225	COG0280	phosphate acetyltransferase
EW640_RS09235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EW640_RS09255	COG1414	Transcriptional regulator
EW640_RS09270	COG3257	ureidoglycine aminohydrolase activity
EW640_RS09285	COG1414	Transcriptional regulator
EW640_RS09310	COG1929	Belongs to the glycerate kinase type-1 family
EW640_RS09320	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EW640_RS09325	COG3960	tartronate-semialdehyde synthase activity
EW640_RS09330	COG2084	Dehydrogenase
EW640_RS09335	COG3622	Belongs to the hyi family
EW640_RS09340	COG2233	PERMEase
EW640_RS09350	COG0523	cobalamin synthesis protein
EW640_RS09375	COG2801	Transposase and inactivated derivatives
EW640_RS09390	COG3415	Transposase
EW640_RS09390	COG2801	Transposase and inactivated derivatives
EW640_RS09395	COG0402	S-adenosylhomocysteine deaminase activity
EW640_RS09405	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EW640_RS09415	COG2252	PERMEase
EW640_RS09460	COG1024	Enoyl-CoA hydratase
EW640_RS09470	COG0028	Belongs to the TPP enzyme family
EW640_RS09495	COG1012	belongs to the aldehyde dehydrogenase family
EW640_RS09505	COG3971	2-oxopent-4-enoate hydratase activity
EW640_RS09530	COG2154	pterin-4-alpha-carbinolamine dehydratase
EW640_RS09555	COG1028	Short-chain dehydrogenase reductase Sdr
EW640_RS09560	COG0785	Cytochrome C biogenesis protein
EW640_RS09570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EW640_RS09575	COG0318	PFAM AMP-dependent synthetase and ligase
EW640_RS09580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EW640_RS09630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EW640_RS09645	COG4948	Mandelate Racemase Muconate Lactonizing
EW640_RS09650	COG2409	Drug exporters of the RND superfamily
EW640_RS09670	COG0730	response to heat
EW640_RS09680	COG0006	proline dipeptidase activity
EW640_RS09685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EW640_RS09695	COG0710	3-dehydroquinate dehydratase activity
EW640_RS09715	COG4175	Glycine betaine
EW640_RS09715	COG0517	IMP dehydrogenase activity
EW640_RS09720	COG4176	ABC-type proline glycine betaine transport system permease component
EW640_RS09745	COG0598	Magnesium transport protein CorA
EW640_RS09755	COG2378	regulation of single-species biofilm formation
EW640_RS09770	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EW640_RS09850	COG3415	Transposase
EW640_RS09850	COG2801	Transposase and inactivated derivatives
EW640_RS09860	COG0823	Involved in the tonB-independent uptake of proteins
EW640_RS09860	COG1506	peptidase
EW640_RS09880	COG0745	RESPONSE REGULATOR receiver
EW640_RS09885	COG1320	monovalent cation:proton antiporter activity
EW640_RS09890	COG2212	antiporter activity
EW640_RS09910	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EW640_RS09910	COG2111	Na H antiporter
EW640_RS09920	COG0717	Belongs to the dCTP deaminase family
EW640_RS09945	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EW640_RS09965	COG0776	regulation of translation
EW640_RS09970	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EW640_RS09975	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EW640_RS09980	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EW640_RS09990	COG0508	dehydrogenase complex catalyzes the overall conversion of
EW640_RS09995	COG0022	dehydrogenase e1 component
EW640_RS10025	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EW640_RS10050	COG1012	belongs to the aldehyde dehydrogenase family
EW640_RS10055	COG1937	Protein conserved in bacteria
EW640_RS10080	COG0745	RESPONSE REGULATOR receiver
EW640_RS10085	COG2205	protein histidine kinase activity
EW640_RS10100	COG3387	PFAM Glycoside hydrolase 15-related
EW640_RS10105	COG1607	acyl-coa hydrolase
EW640_RS10125	COG1132	(ABC) transporter
EW640_RS10140	COG2226	methyltransferase
EW640_RS10165	COG3896	Chloramphenicol phosphotransferase-like protein
EW640_RS10185	COG2323	membrane
EW640_RS10200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EW640_RS10205	COG0697	spore germination
EW640_RS10215	COG2860	membrane
EW640_RS10230	COG1132	(ABC) transporter
EW640_RS10255	COG2076	Multidrug Resistance protein
EW640_RS10280	COG0305	Participates in initiation and elongation during chromosome replication
EW640_RS10305	COG2801	Transposase and inactivated derivatives
EW640_RS10305	COG3415	Transposase
EW640_RS10310	COG0583	DNA-binding transcription factor activity
EW640_RS10325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EW640_RS10330	COG2733	membrane
EW640_RS10340	COG0789	Transcriptional regulator
EW640_RS10345	COG0359	binds to the 23S rRNA
EW640_RS10350	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EW640_RS10360	COG0360	Binds together with S18 to 16S ribosomal RNA
EW640_RS10370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EW640_RS10375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EW640_RS10380	COG0617	tRNA 3'-terminal CCA addition
EW640_RS10405	COG0492	ferredoxin-NADP+ reductase activity
EW640_RS10410	COG3118	belongs to the thioredoxin family
EW640_RS10415	COG0860	N-Acetylmuramoyl-L-alanine amidase
EW640_RS10415	COG3409	Peptidoglycan-binding domain 1 protein
EW640_RS10420	COG1475	DNA binding
EW640_RS10425	COG1192	Involved in chromosome partitioning
EW640_RS10430	COG0357	Ribosomal RNA small subunit methyltransferase G
EW640_RS10440	COG0706	membrane insertase activity
EW640_RS10445	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EW640_RS10450	COG0594	ribonuclease P activity
EW640_RS10455	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EW640_RS10460	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EW640_RS10465	COG0592	DNA-directed DNA polymerase activity
EW640_RS10470	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EW640_RS10485	COG0187	DNA topoisomerase II activity
EW640_RS10490	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EW640_RS10510	COG0582	viral genome integration into host DNA
EW640_RS10525	COG2801	Transposase and inactivated derivatives
EW640_RS10525	COG3415	Transposase
EW640_RS10530	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EW640_RS10540	COG1309	transcriptional regulator
EW640_RS10565	COG3454	Phosphonate metabolism
EW640_RS10640	COG0346	lactoylglutathione lyase activity
EW640_RS10645	COG0640	Transcriptional regulator
EW640_RS10665	COG0789	Transcriptional regulator
EW640_RS10680	COG3547	Transposase (IS116 IS110 IS902 family)
EW640_RS10685	COG2801	Transposase and inactivated derivatives
EW640_RS10725	COG2801	Transposase and inactivated derivatives
EW640_RS10725	COG3415	Transposase
EW640_RS10750	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EW640_RS10755	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EW640_RS10760	COG1012	belongs to the aldehyde dehydrogenase family
EW640_RS10770	COG2268	Band 7 protein
EW640_RS10795	COG4585	Histidine kinase
EW640_RS10795	COG2203	Gaf domain
EW640_RS10800	COG0577	efflux transmembrane transporter activity
EW640_RS10805	COG1136	(ABC) transporter
EW640_RS10820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EW640_RS10830	COG2364	Membrane
EW640_RS10855	COG3764	Sortase (surface protein transpeptidase)
EW640_RS10870	COG0515	serine threonine protein kinase
EW640_RS10875	COG0515	serine threonine protein kinase
EW640_RS10880	COG0768	penicillin binding
EW640_RS10895	COG1716	ATPase activity
EW640_RS10915	COG1228	amidohydrolase
EW640_RS10920	COG1473	amidohydrolase
EW640_RS10935	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EW640_RS10950	COG3842	ATPase activity
EW640_RS10960	COG1176	ABC-type spermidine putrescine transport system, permease component I
EW640_RS10970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EW640_RS10980	COG1012	belongs to the aldehyde dehydrogenase family
EW640_RS10990	COG1115	amino acid carrier protein
EW640_RS11005	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EW640_RS11010	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EW640_RS11025	COG0243	molybdopterin cofactor binding
EW640_RS11025	COG3383	formate dehydrogenase (NAD+) activity
EW640_RS11030	COG3383	formate dehydrogenase (NAD+) activity
EW640_RS11030	COG0243	molybdopterin cofactor binding
EW640_RS11035	COG0437	4 iron, 4 sulfur cluster binding
EW640_RS11055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EW640_RS11060	COG0640	Transcriptional regulator
EW640_RS11080	COG2197	response regulator
EW640_RS11085	COG4585	Histidine kinase
EW640_RS11090	COG0515	serine threonine protein kinase
EW640_RS11115	COG0477	Major facilitator Superfamily
EW640_RS11130	COG2226	methyltransferase
EW640_RS11145	COG0351	phosphomethylpyrimidine kinase
EW640_RS11190	COG1028	Short-chain dehydrogenase reductase Sdr
EW640_RS11195	COG0514	ATP-dependent DNA helicase (RecQ)
EW640_RS11200	COG0709	Synthesizes selenophosphate from selenide and ATP
EW640_RS11210	COG1921	L-seryl-tRNASec selenium transferase activity
EW640_RS11230	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EW640_RS11235	COG0508	dehydrogenase complex catalyzes the overall conversion of
EW640_RS11270	COG2030	dehydratase
EW640_RS11270	COG1012	belongs to the aldehyde dehydrogenase family
EW640_RS11310	COG0477	Major facilitator Superfamily
EW640_RS11315	COG1609	Transcriptional regulator
EW640_RS11325	COG3396	Phenylacetate-CoA oxygenase
EW640_RS11330	COG3460	Phenylacetate-CoA oxygenase
EW640_RS11335	COG3396	Phenylacetate-CoA oxygenase
EW640_RS11340	COG2151	metal-sulfur cluster biosynthetic enzyme
EW640_RS11345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EW640_RS11355	COG0435	Glutathione S-transferase
EW640_RS11365	COG1960	acyl-CoA dehydrogenase activity
EW640_RS11370	COG4145	pantothenate transmembrane transporter activity
EW640_RS11390	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EW640_RS11400	COG0405	Gamma-glutamyltransferase
EW640_RS11415	COG2807	transmembrane transport
EW640_RS11430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EW640_RS11435	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EW640_RS11450	COG3842	ATPase activity
EW640_RS11460	COG1177	transmembrane transport
EW640_RS11470	COG2986	histidine ammonia-lyase
EW640_RS11475	COG2124	cytochrome p450
EW640_RS11495	COG3835	regulator
EW640_RS11520	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EW640_RS11565	COG0577	efflux transmembrane transporter activity
EW640_RS11565	COG1136	(ABC) transporter
EW640_RS11575	COG0745	RESPONSE REGULATOR receiver
EW640_RS11580	COG2205	protein histidine kinase activity
EW640_RS11620	COG0653	protein targeting
EW640_RS11635	COG0653	protein targeting
EW640_RS11640	COG2197	response regulator
EW640_RS11645	COG4585	Histidine kinase
EW640_RS11710	COG0697	spore germination
EW640_RS11715	COG2910	NAD(P)H-binding
EW640_RS11720	COG1846	Transcriptional regulator
EW640_RS11730	COG2814	Major facilitator Superfamily
EW640_RS11745	COG3473	Maleate cis-trans isomerase
EW640_RS11755	COG2814	Major facilitator Superfamily
EW640_RS11770	COG2801	Transposase and inactivated derivatives
EW640_RS11790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EW640_RS11810	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EW640_RS11815	COG2188	Transcriptional regulator
EW640_RS11840	COG0477	Major facilitator Superfamily
EW640_RS11850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EW640_RS11855	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EW640_RS11860	COG1028	Short-chain dehydrogenase reductase Sdr
EW640_RS11865	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EW640_RS11875	COG0583	DNA-binding transcription factor activity
EW640_RS11885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EW640_RS11935	COG2186	Transcriptional regulator
EW640_RS11940	COG1620	l-lactate permease
EW640_RS11945	COG0247	lactate metabolic process
EW640_RS11950	COG1139	Iron-sulfur cluster binding protein
EW640_RS11955	COG1556	Lactate utilization protein
EW640_RS11960	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EW640_RS11985	COG0438	transferase activity, transferring glycosyl groups
EW640_RS11995	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EW640_RS11995	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EW640_RS12020	COG1228	amidohydrolase
EW640_RS12025	COG2986	histidine ammonia-lyase
EW640_RS12035	COG0402	S-adenosylhomocysteine deaminase activity
EW640_RS12040	COG1414	Transcriptional regulator
EW640_RS12045	COG0303	'Molybdopterin
EW640_RS12050	COG2318	DinB family
EW640_RS12075	COG0315	cyclic pyranopterin monophosphate synthase activity
EW640_RS12090	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EW640_RS12130	COG0154	amidase activity
EW640_RS12145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EW640_RS12150	COG0569	domain protein
EW640_RS12160	COG4585	Histidine kinase
EW640_RS12165	COG2197	response regulator
EW640_RS12180	COG0579	oxidoreductase
EW640_RS12235	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EW640_RS12240	COG1120	ATPase activity
EW640_RS12250	COG0589	response to stress
EW640_RS12265	COG0247	lactate metabolic process
EW640_RS12265	COG0277	FAD linked oxidase domain protein
EW640_RS12275	COG0483	inositol monophosphate 1-phosphatase activity
EW640_RS12280	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EW640_RS12290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EW640_RS12295	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EW640_RS12295	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EW640_RS12300	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EW640_RS12305	COG0509	glycine decarboxylation via glycine cleavage system
EW640_RS12310	COG1760	l-serine dehydratase
EW640_RS12325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EW640_RS12340	COG0390	transport system, permease component
EW640_RS12370	COG1331	Highly conserved protein containing a thioredoxin domain
EW640_RS12405	COG1362	aminopeptidase activity
EW640_RS12425	COG3590	peptidase
EW640_RS12435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EW640_RS12465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EW640_RS12480	COG3226	Transcriptional regulator
EW640_RS12520	COG2197	response regulator
EW640_RS12530	COG1937	Protein conserved in bacteria
EW640_RS12555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EW640_RS12565	COG0745	RESPONSE REGULATOR receiver
EW640_RS12580	COG2217	Heavy metal translocating P-type atpase
EW640_RS12595	COG2826	transposase and inactivated derivatives, IS30 family
EW640_RS12600	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
EW640_RS12610	COG2130	NADP-dependent
EW640_RS12615	COG0252	asparaginase activity
EW640_RS12660	COG0783	Belongs to the Dps family
EW640_RS12665	COG2188	Transcriptional regulator
EW640_RS12670	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EW640_RS12670	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EW640_RS12695	COG1174	glycine betaine transport
EW640_RS12705	COG1174	glycine betaine transport
EW640_RS12735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EW640_RS12755	COG0443	Heat shock 70 kDa protein
EW640_RS12760	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EW640_RS12765	COG0484	heat shock protein binding
EW640_RS12770	COG0789	Transcriptional regulator
EW640_RS12785	COG0471	metal ion transport
EW640_RS12800	COG1597	lipid kinase activity
EW640_RS12805	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EW640_RS12810	COG0561	phosphatase activity
EW640_RS12830	COG0561	phosphatase activity
EW640_RS12845	COG0604	alcohol dehydrogenase
EW640_RS12865	COG0789	Transcriptional regulator
EW640_RS12870	COG0659	secondary active sulfate transmembrane transporter activity
EW640_RS12875	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EW640_RS12880	COG0798	PFAM Bile acid sodium symporter
EW640_RS12910	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
EW640_RS12915	COG0154	amidase activity
EW640_RS12920	COG1309	transcriptional regulator
EW640_RS12925	COG2409	Drug exporters of the RND superfamily
EW640_RS12940	COG1316	TRANSCRIPTIONal
EW640_RS12975	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
EW640_RS12985	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EW640_RS13005	COG1012	belongs to the aldehyde dehydrogenase family
EW640_RS13015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EW640_RS13025	COG0579	oxidoreductase
EW640_RS13045	COG0745	RESPONSE REGULATOR receiver
EW640_RS13055	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EW640_RS13105	COG1216	Glycosyl transferase, family 2
EW640_RS13115	COG1335	isochorismatase
EW640_RS13120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EW640_RS13130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EW640_RS13135	COG0277	FAD linked oxidase domain protein
EW640_RS13145	COG0179	Fumarylacetoacetate (FAA) hydrolase
EW640_RS13150	COG0343	queuine tRNA-ribosyltransferase activity
EW640_RS13175	COG2814	Major facilitator Superfamily
EW640_RS13230	COG0300	oxidoreductase activity
EW640_RS13305	COG0693	protein deglycase activity
EW640_RS13375	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EW640_RS13385	COG3655	Transcriptional regulator
EW640_RS13405	COG1121	(ABC) transporter
EW640_RS13415	COG1408	metallophosphoesterase
EW640_RS13420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EW640_RS13470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EW640_RS13515	COG1205	dead DEAH box helicase
EW640_RS13515	COG1111	helicase
EW640_RS13525	COG1754	DNA topoisomerase type I activity
EW640_RS13525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EW640_RS13540	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EW640_RS13565	COG2391	methyltransferase activity
EW640_RS13570	COG0425	Belongs to the sulfur carrier protein TusA family
EW640_RS13575	COG0589	response to stress
EW640_RS13580	COG0557	exoribonuclease II activity
EW640_RS13585	COG1309	transcriptional regulator
EW640_RS13600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EW640_RS13610	COG1960	acyl-CoA dehydrogenase activity
EW640_RS13615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EW640_RS13620	COG0154	amidase activity
EW640_RS13645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EW640_RS13655	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EW640_RS13660	COG1012	belongs to the aldehyde dehydrogenase family
EW640_RS13665	COG1028	Short-chain dehydrogenase reductase Sdr
EW640_RS13675	COG1473	amidohydrolase
EW640_RS13685	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EW640_RS13695	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EW640_RS13715	COG0318	PFAM AMP-dependent synthetase and ligase
EW640_RS13735	COG0242	peptide deformylase activity
EW640_RS13745	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EW640_RS13755	COG0477	Major facilitator Superfamily
EW640_RS13760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EW640_RS13780	COG2027	D-alanyl-D-alanine carboxypeptidase
EW640_RS13790	COG0037	tRNA processing
EW640_RS13800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EW640_RS13805	COG0302	gtp cyclohydrolase
EW640_RS13815	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EW640_RS13840	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EW640_RS13890	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EW640_RS13905	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
EW640_RS13920	COG1012	belongs to the aldehyde dehydrogenase family
EW640_RS13925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EW640_RS13930	COG0583	DNA-binding transcription factor activity
EW640_RS13935	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EW640_RS13945	COG1122	ATPase activity
EW640_RS13950	COG4721	ABC-type cobalt transport system, permease component
EW640_RS13965	COG2079	MmgE PrpD family protein
EW640_RS13970	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EW640_RS13980	COG1024	Enoyl-CoA hydratase
EW640_RS13990	COG1131	(ABC) transporter
EW640_RS14000	COG1196	nuclear chromosome segregation
EW640_RS14010	COG0248	Ppx GppA phosphatase
EW640_RS14015	COG1082	Xylose isomerase domain protein TIM barrel
EW640_RS14025	COG0659	secondary active sulfate transmembrane transporter activity
EW640_RS14030	COG0569	domain protein
EW640_RS14035	COG0123	including yeast histone deacetylase and acetoin utilization protein
EW640_RS14050	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EW640_RS14055	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EW640_RS14065	COG0113	porphobilinogen synthase activity
EW640_RS14075	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EW640_RS14080	COG0406	alpha-ribazole phosphatase activity
EW640_RS14090	COG0785	Cytochrome C biogenesis protein
EW640_RS14095	COG1333	cytochrome c biogenesis protein
EW640_RS14100	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EW640_RS14105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EW640_RS14125	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EW640_RS14130	COG4948	Mandelate Racemase Muconate Lactonizing
EW640_RS14160	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EW640_RS14175	COG2226	methyltransferase
EW640_RS14180	COG0644	oxidoreductase
EW640_RS14200	COG1666	GTP binding
EW640_RS14245	COG2066	Belongs to the glutaminase family
EW640_RS14245	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EW640_RS14250	COG0584	glycerophosphoryl diester phosphodiesterase
EW640_RS14265	COG0318	PFAM AMP-dependent synthetase and ligase
EW640_RS14285	COG2030	dehydratase
EW640_RS14295	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EW640_RS14300	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EW640_RS14315	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EW640_RS14320	COG0250	Participates in transcription elongation, termination and antitermination
EW640_RS14325	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EW640_RS14330	COG0081	regulation of translation
EW640_RS14340	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EW640_RS14345	COG0222	ribosome binding
EW640_RS14370	COG0085	RNA polymerase activity
EW640_RS14375	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EW640_RS14385	COG0205	6-phosphofructokinase activity
EW640_RS14395	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EW640_RS14400	COG0049	tRNA binding
EW640_RS14405	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EW640_RS14410	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EW640_RS14435	COG0051	transcription antitermination factor activity, RNA binding
EW640_RS14440	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EW640_RS14445	COG0088	Forms part of the polypeptide exit tunnel
EW640_RS14450	COG0089	rRNA binding
EW640_RS14455	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EW640_RS14460	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EW640_RS14465	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EW640_RS14470	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EW640_RS14475	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EW640_RS14480	COG0255	Belongs to the universal ribosomal protein uL29 family
EW640_RS14485	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EW640_RS14490	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EW640_RS14495	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EW640_RS14500	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EW640_RS14505	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EW640_RS14510	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EW640_RS14515	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EW640_RS14520	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EW640_RS14525	COG1841	ribosomal large subunit assembly
EW640_RS14530	COG0200	Binds to the 23S rRNA
EW640_RS14540	COG0563	adenylate kinase activity
EW640_RS14545	COG0024	Methionine aminopeptidase
EW640_RS14575	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EW640_RS14580	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EW640_RS14585	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EW640_RS14590	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EW640_RS14595	COG0202	RNA polymerase activity
EW640_RS14600	COG0203	ribosomal protein L17
EW640_RS14635	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EW640_RS14640	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate