locus-tag class description GUY37_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GUY37_RS00010 ENOG41084CH 50S ribosomal protein l34 GUY37_RS00020 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GUY37_RS00025 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GUY37_RS00035 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GUY37_RS00040 ENOG4107QJE Chromosome Partitioning Protein GUY37_RS00050 ENOG4108E1C hydrolase GUY37_RS00055 ENOG4105K63 Thioredoxin GUY37_RS00060 ENOG4105C3M thioredoxin reductase GUY37_RS00085 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GUY37_RS00090 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GUY37_RS00095 ENOG4105BZ4 penicillin-binding protein GUY37_RS00105 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) GUY37_RS00115 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GUY37_RS00120 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GUY37_RS00135 ENOG4105CWC Acetylornithine deacetylase GUY37_RS00140 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GUY37_RS00145 ENOG4106BRA Membrane GUY37_RS00165 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GUY37_RS00180 ENOG4105CDU Replicative dna helicase GUY37_RS00210 ENOG4108428 Inherit from COG: -acetyltransferase GUY37_RS00240 ENOG4105CH2 amidohydrolase GUY37_RS00260 ENOG4105VEQ Cold shock protein GUY37_RS00265 ENOG4108KGH TRANSCRIPTIONal GUY37_RS00270 ENOG41080RH Thioredoxin GUY37_RS00280 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GUY37_RS00285 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GUY37_RS00290 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein GUY37_RS00305 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) GUY37_RS00315 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) GUY37_RS00320 ENOG4105EM7 Selenocysteine-specific translation elongation factor GUY37_RS00340 ENOG4105CE7 Amidase, hydantoinase carbamoylase family GUY37_RS00345 ENOG4105C7K acetolactate synthase GUY37_RS00350 ENOG4105CSH Transporter GUY37_RS00370 ENOG4105CQB FAD linked oxidase domain protein GUY37_RS00385 ENOG4105BZC d-serine deaminase GUY37_RS00400 ENOG4105CUB amino acid GUY37_RS00410 ENOG4105CMU LysR family (Transcriptional regulator GUY37_RS00415 ENOG4105DVW rieske (2Fe-2S) GUY37_RS00425 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) GUY37_RS00445 ENOG4108JQ7 (ABC) transporter GUY37_RS00450 ENOG4105C3U ABC transporter GUY37_RS00455 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GUY37_RS00470 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GUY37_RS00475 ENOG4105CTU Proline racemase GUY37_RS00490 ENOG4105CSH Transporter GUY37_RS00495 ENOG4105CXN decarboxylase GUY37_RS00500 ENOG4105DDW LysR family Transcriptional regulator GUY37_RS00540 ENOG4105CIG ABC transporter GUY37_RS00550 ENOG4105C85 amino acid GUY37_RS00570 ENOG4108IUX (ABC) transporter GUY37_RS00595 ENOG4105WH1 Two component transcriptional regulator luxr family GUY37_RS00600 ENOG4105BZU Histidine kinase GUY37_RS00610 ENOG4105RNG membrane GUY37_RS00640 ENOG4105EN6 Membrane GUY37_RS00650 ENOG4105CSR polyphosphate kinase 2 GUY37_RS00660 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) GUY37_RS00665 ENOG4107SFI Major Facilitator superfamily GUY37_RS00685 ENOG4105C9U ATP-dependent DNA helicase RecQ GUY37_RS00690 ENOG410836F Transposase GUY37_RS00725 ENOG4105BZP glycoside hydrolase 15-related GUY37_RS00745 ENOG4108FKE two-component system sensor kinase GUY37_RS00750 ENOG4108PYU two-component system response regulator GUY37_RS00775 ENOG4105VPX protein, conserved in bacteria GUY37_RS00785 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GUY37_RS00790 ENOG4108MRH transcriptional regulatory protein GUY37_RS00800 ENOG4105C26 Dehydrogenase GUY37_RS00820 ENOG4105CSH Transporter GUY37_RS00830 ENOG4107QTF adenylosuccinate lyase GUY37_RS00855 ENOG4105CPP Dehydrogenase, E1 component GUY37_RS00860 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 GUY37_RS00865 ENOG4108M0I Transcriptional regulator GUY37_RS00880 ENOG4105W0E 50S ribosomal protein L33 GUY37_RS00885 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GUY37_RS00890 ENOG4108426 dNA-binding protein GUY37_RS00920 ENOG4105DFA alanine racemase domain protein GUY37_RS00950 ENOG4105DHP deoxycytidine triphosphate deaminase GUY37_RS00960 ENOG4105D65 subunit l GUY37_RS00965 ENOG4105MKQ Monovalent cation H antiporter subunit C GUY37_RS00970 ENOG4108JPZ Monovalent cation H antiporter subunit D GUY37_RS00975 ENOG4105SC1 monovalent cation H antiporter subunit E GUY37_RS00985 ENOG4105KJM monovalent cation h antiporter subunit g GUY37_RS00990 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GUY37_RS00995 ENOG41062D9 Histidine kinase GUY37_RS01005 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein GUY37_RS01010 ENOG4105CE4 GlcNAc 6-P deacetylase GUY37_RS01045 ENOG4105F5W AtP-binding protein GUY37_RS01085 ENOG4108HQS Glycine betaine GUY37_RS01090 ENOG4108IJ7 Glycine betaine GUY37_RS01100 ENOG4105FF2 Type I DHQase GUY37_RS01125 ENOG4105IIU Aminopeptidase GUY37_RS01130 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GUY37_RS01155 ENOG4105DTQ mandelate racemase muconate lactonizing GUY37_RS01215 ENOG4108Z6Z Transcriptional regulator GUY37_RS01240 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GUY37_RS01250 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase GUY37_RS01255 ENOG410680H amp-dependent synthetase and ligase GUY37_RS01260 ENOG4105E2T synthase III GUY37_RS01280 ENOG4105CBC glutamate synthase GUY37_RS01290 ENOG4105D94 Major Facilitator Superfamily GUY37_RS01295 ENOG4105E39 Enoyl-CoA hydratase GUY37_RS01305 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GUY37_RS01315 ENOG4105DWY Agmatine deiminase GUY37_RS01320 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GUY37_RS01335 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GUY37_RS01355 ENOG4105CHR reductase GUY37_RS01420 ENOG4105VBF alkaline shock protein GUY37_RS01425 ENOG4105EMN RNA polymerase sigma factor GUY37_RS01445 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GUY37_RS01450 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GUY37_RS01465 ENOG4105C1G acyl-Coa dehydrogenase GUY37_RS01470 ENOG4105X7H acyl-CoA dehydrogenase GUY37_RS01485 ENOG4105WH1 Two component transcriptional regulator luxr family GUY37_RS01495 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GUY37_RS01510 ENOG4107WAU Protein tyrosine phosphatase GUY37_RS01515 ENOG4105D3Q Sugar transferase GUY37_RS01530 ENOG4107YJ4 chain length determinant protein GUY37_RS01555 ENOG4105DIM ABC transporter GUY37_RS01560 ENOG4105CIG ABC transporter GUY37_RS01565 ENOG4108X07 Tetr family transcriptional regulator GUY37_RS01595 ENOG4105BZG amino acid carrier protein GUY37_RS01605 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GUY37_RS01620 ENOG4105W1N transcriptional regulator GUY37_RS01625 ENOG4108YYH Nadph-dependent fmn reductase GUY37_RS01635 ENOG4105WH1 Two component transcriptional regulator luxr family GUY37_RS01640 ENOG4105BZU Histidine kinase GUY37_RS01660 ENOG4105BZU Histidine kinase GUY37_RS01670 ENOG4105WH1 Two component transcriptional regulator luxr family GUY37_RS01705 ENOG4105ENE Histidine kinase GUY37_RS01710 ENOG4105WH1 Two component transcriptional regulator luxr family GUY37_RS01725 ENOG4108QY0 Membrane GUY37_RS01740 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GUY37_RS01755 ENOG4107RB3 L-asparaginase GUY37_RS01790 ENOG4105C7K acetolactate synthase GUY37_RS01795 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GUY37_RS01800 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GUY37_RS01820 ENOG4105DXB Major Facilitator superfamily GUY37_RS01825 ENOG4105KAF membrAne GUY37_RS01835 ENOG4105ENV phosphonate C-P lyase system protein PhnK GUY37_RS01845 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GUY37_RS01855 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) GUY37_RS01875 ENOG4105C9U ATP-dependent DNA helicase RecQ GUY37_RS01895 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GUY37_RS01910 ENOG4105R3A Nitrate reductase GUY37_RS01915 ENOG4108IUE nitrate reductase beta subunit GUY37_RS01930 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GUY37_RS01940 ENOG4107QTZ amino acid GUY37_RS01945 ENOG4105DRR Transcriptional regulator, GntR family GUY37_RS01965 ENOG4105CKI cobalamin synthesis protein GUY37_RS01975 ENOG41073TP transcriptional regulator GUY37_RS01980 ENOG4105DAA L-lactate GUY37_RS01990 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein GUY37_RS01995 ENOG4105J76 Periplasmic binding protein GUY37_RS02005 ENOG4105CHH sulfate transporter GUY37_RS02010 ENOG4105CFG Acts as a chaperone (By similarity) GUY37_RS02015 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GUY37_RS02020 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GUY37_RS02025 ENOG4105KNI merR family transcriptional Regulator GUY37_RS02045 ENOG4107TE5 Lipid kinase GUY37_RS02050 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GUY37_RS02055 ENOG4108X4Q Hydrolase GUY37_RS02060 ENOG4108KP7 hydrolase GUY37_RS02075 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GUY37_RS02095 ENOG4105CUB amino acid GUY37_RS02105 ENOG4108151 Beta-lactamase domain protein GUY37_RS02120 ENOG4108IG5 Transcriptional regulator GUY37_RS02125 ENOG4105EYF MMPL domain protein GUY37_RS02140 ENOG4108KGH TRANSCRIPTIONal GUY37_RS02150 ENOG4105C26 Dehydrogenase GUY37_RS02165 ENOG4105MWK D-amino acid dehydrogenase, small subunit GUY37_RS02170 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GUY37_RS02175 ENOG4105CTU Proline racemase GUY37_RS02180 ENOG4105CHR reductase GUY37_RS02185 ENOG4105CHR reductase GUY37_RS02195 ENOG4105DRP amino acid AbC transporter GUY37_RS02205 ENOG4105DG4 malate L-lactate dehydrogenase GUY37_RS02215 ENOG4105BZG amino acid carrier protein GUY37_RS02225 ENOG4105C26 Dehydrogenase GUY37_RS02230 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GUY37_RS02250 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) GUY37_RS02270 ENOG4105CDH Citrulline--aspartate ligase GUY37_RS02285 ENOG4105E5D amino acid GUY37_RS02300 ENOG4108RWI nicotinamidase GUY37_RS02305 ENOG4105EYF MMPL domain protein GUY37_RS02315 ENOG4105WH1 Two component transcriptional regulator luxr family GUY37_RS02370 ENOG4105CSH Transporter GUY37_RS02375 ENOG4107HP6 Transcriptional regulator GUY37_RS02380 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GUY37_RS02400 ENOG4105BZU Histidine kinase GUY37_RS02415 ENOG4107T8Q Glycosyl transferase (Group 1 GUY37_RS02420 ENOG4107EF8 Glycosyl transferase (Group 1 GUY37_RS02425 ENOG4105BZ1 (ABC) transporter GUY37_RS02430 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) GUY37_RS02445 ENOG4105CPC Aldo Keto reductase GUY37_RS02450 ENOG4105KZX Pterin carbinolamine dehydratase GUY37_RS02455 ENOG4105C6Z Gluconate GUY37_RS02460 ENOG4105FDP GntR family transcriptional regulator GUY37_RS02465 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) GUY37_RS02470 ENOG4107RJ1 sodium solute GUY37_RS02475 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GUY37_RS02490 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) GUY37_RS02495 ENOG4108R6G acetyltransferase GUY37_RS02505 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands GUY37_RS02615 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GUY37_RS02630 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) GUY37_RS02645 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GUY37_RS02650 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GUY37_RS02655 ENOG4107NHD transcriptional regulator GUY37_RS02665 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands GUY37_RS02685 ENOG4105WH1 Two component transcriptional regulator luxr family GUY37_RS02690 ENOG4107VHA regulatoR GUY37_RS02695 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GUY37_RS02705 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GUY37_RS02745 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GUY37_RS02755 ENOG4105SHT UspA domain-containing protein GUY37_RS02775 ENOG4105DEN Luciferase family GUY37_RS02820 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GUY37_RS02840 ENOG4105C09 Bile acid GUY37_RS02845 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GUY37_RS02855 ENOG4108594 Permease of the drug metabolite transporter GUY37_RS02865 ENOG4105BZU Histidine kinase GUY37_RS02870 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GUY37_RS02885 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GUY37_RS02895 ENOG4105C85 amino acid GUY37_RS02915 ENOG4105C8J )-transporter GUY37_RS02920 ENOG4105C8N cysteinyl-tRNA synthetase GUY37_RS02925 ENOG4105C2N RNA methyltransferase TrmH family group 3 GUY37_RS02930 ENOG4105CUB amino acid GUY37_RS02935 ENOG4105CHR reductase GUY37_RS02950 ENOG4105ETE Transcriptional regulator (LacI family GUY37_RS02955 ENOG4105CQ4 Transcriptional regulator GUY37_RS02965 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase GUY37_RS02970 ENOG4108762 serine threonine protein kinase GUY37_RS03000 ENOG4105D4Y metalloprotease GUY37_RS03010 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) GUY37_RS03025 ENOG4105CI2 imidazolone-5-propionate hydrolase GUY37_RS03035 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GUY37_RS03055 ENOG4105VEQ Cold shock protein GUY37_RS03060 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GUY37_RS03085 ENOG4105WQ3 Rna-binding protein GUY37_RS03095 ENOG4105D0M Protease HtpX homolog GUY37_RS03120 ENOG4105BZU Histidine kinase GUY37_RS03125 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GUY37_RS03160 ENOG4105VEQ Cold shock protein GUY37_RS03180 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GUY37_RS03190 ENOG4105C26 Dehydrogenase GUY37_RS03200 ENOG4105K4H Nlp p60 protein GUY37_RS03275 ENOG4105CSH Transporter GUY37_RS03310 ENOG4107ZR7 Membrane GUY37_RS03350 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) GUY37_RS03365 ENOG4105DIK (ABC) transporter GUY37_RS03370 ENOG4105CC5 ABC transporter GUY37_RS03390 ENOG4105C26 Dehydrogenase GUY37_RS03395 ENOG4105CRW Short chain fatty acid transporter GUY37_RS03400 ENOG4105C94 Transporter GUY37_RS03405 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) GUY37_RS03410 ENOG4108R3E Dna-3-methyladenine glycosylase i GUY37_RS03415 ENOG4105M6F mutator MutT protein GUY37_RS03445 ENOG4105MHT Transcriptional regulator, ARSR family GUY37_RS03465 ENOG4105CPC Aldo Keto reductase GUY37_RS03490 ENOG4108KTG Membrane protein, drug metabolite transporter GUY37_RS03515 ENOG4105EGI Transcriptional regulator GUY37_RS03525 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GUY37_RS03550 ENOG4105CEY Amp-dependent synthetase and ligase GUY37_RS03570 ENOG4105EWV Sodium calcium exchanger membrane region GUY37_RS03590 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) GUY37_RS03615 ENOG4105CNI cell division protein FtsW GUY37_RS03625 ENOG4108RIR Molybdenum cofactor biosynthesis protein GUY37_RS03630 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GUY37_RS03635 ENOG4105C9B Cysteine desulfurase GUY37_RS03650 ENOG4105K5X acetyltransferase GUY37_RS03665 ENOG4105C1G acyl-Coa dehydrogenase GUY37_RS03675 ENOG4106P37 HTH-type transcriptional regulator YjhI GUY37_RS03690 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GUY37_RS03700 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GUY37_RS03720 ENOG4105EW9 transcriptional regulator AsnC family GUY37_RS03725 ENOG4105CSH Transporter GUY37_RS03730 ENOG4105EFZ amidohydrolase GUY37_RS03735 ENOG4105C7K acetolactate synthase GUY37_RS03740 ENOG4108JQ1 Dehydrogenase GUY37_RS03755 ENOG4105CMR udp-glucose 4-epimerase GUY37_RS03760 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) GUY37_RS03800 ENOG4105C26 Dehydrogenase GUY37_RS03815 ENOG4107TE1 transport protein GUY37_RS03825 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) GUY37_RS03835 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth GUY37_RS03860 ENOG4107ETC gas vesicle protein GUY37_RS03880 ENOG4105CH6 catalase GUY37_RS03930 ENOG4105EWK phytoene GUY37_RS03935 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GUY37_RS03970 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GUY37_RS03980 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction GUY37_RS03995 ENOG4105FDF Could be involved in DNA repair (By similarity) GUY37_RS04005 ENOG4105BZP glycoside hydrolase 15-related GUY37_RS04010 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GUY37_RS04030 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GUY37_RS04055 ENOG4105CSH Transporter GUY37_RS04060 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase GUY37_RS04065 ENOG41067RQ csbd family GUY37_RS04095 ENOG4105EV8 ectoine hydroxylase GUY37_RS04100 ENOG4105CSH Transporter GUY37_RS04130 ENOG4105C7W Xanthine dehydrogenase GUY37_RS04135 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding GUY37_RS04140 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit GUY37_RS04145 ENOG4105DQE DNA ligase GUY37_RS04155 ENOG4105CBC glutamate synthase GUY37_RS04160 ENOG4105CSH Transporter GUY37_RS04165 ENOG4108ZHJ Organic hydroperoxide resistance protein GUY37_RS04170 ENOG4107ZYR domain protein GUY37_RS04175 ENOG4105CZN Potassium uptake protein GUY37_RS04180 ENOG4108JYK Dehydrogenase GUY37_RS04225 ENOG4107QUT magnesium and cobalt transport protein CorA GUY37_RS04230 ENOG4105BZ9 Cytochrome C oxidase, subunit I GUY37_RS04240 ENOG4105CPC Aldo Keto reductase GUY37_RS04270 ENOG4107YSK Glycerol-3-phosphate cytidylyltransferase GUY37_RS04285 ENOG4105EXC Acyl-transferase GUY37_RS04295 ENOG4107XU6 Glycosyl transferase (Group 1 GUY37_RS04305 ENOG4107RZX Teichoic acid biosynthesis protein GUY37_RS04340 ENOG4105DEF Extracellular solute-binding protein, family 5 GUY37_RS04345 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GUY37_RS04350 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GUY37_RS04370 ENOG4108HUF Transporter GUY37_RS04415 ENOG4105CGD Nad-dependent epimerase dehydratase GUY37_RS04425 ENOG4105CVP deoxyribo-dipyrimidine photolyase GUY37_RS04450 ENOG4105C1J atp-dependent rna helicase GUY37_RS04475 ENOG4108MGF sugar kinase GUY37_RS04480 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GUY37_RS04485 ENOG4105DU0 nucleoside hydrolase GUY37_RS04505 ENOG4108ITV Inner membrane protein yqcE GUY37_RS04520 ENOG4105DIA mandelate racemase muconate lactonizing GUY37_RS04525 ENOG4105CQB FAD linked oxidase domain protein GUY37_RS04540 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein GUY37_RS04550 ENOG4105D5U fad dependent oxidoreductase GUY37_RS04575 ENOG41090UD (LipO)protein GUY37_RS04605 ENOG4105CKU formyltetrahydrofolate synthetase GUY37_RS04610 ENOG4105II7 pyrroline-5-carboxylate reductase GUY37_RS04620 ENOG4105EWI Short-chain dehydrogenase reductase Sdr GUY37_RS04630 ENOG4105BZU Histidine kinase GUY37_RS04640 ENOG4105D01 (LipO)protein GUY37_RS04645 ENOG4108UMI ABC transporter, permease GUY37_RS04655 ENOG41089I4 Inherit from COG: Glycosyl transferase, family 2 GUY37_RS04685 ENOG4107QRS glycosyltransferase group 2 family protein GUY37_RS04690 ENOG4105D2T synthase GUY37_RS04700 ENOG4105FF9 glycosyl transferase, family 39 GUY37_RS04740 ENOG4105F8V Hydrolase, tatD family GUY37_RS04745 ENOG4106839 domain protein GUY37_RS04750 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GUY37_RS04755 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GUY37_RS04775 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GUY37_RS04785 ENOG4105ENX hydrolase GUY37_RS04790 ENOG4105ENX hydrolase GUY37_RS04800 ENOG4105CEY Amp-dependent synthetase and ligase GUY37_RS04810 ENOG4105CSU acyl-Coa dehydrogenase GUY37_RS04820 ENOG4105D3G Pseudouridine synthase GUY37_RS04830 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GUY37_RS04840 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) GUY37_RS04845 ENOG4105DUU IucA IucC family protein GUY37_RS04855 ENOG4105DFW ABC transporter GUY37_RS04860 ENOG4105C2J ABC transporter GUY37_RS04865 ENOG4108HWW ABC transporter GUY37_RS04890 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GUY37_RS04895 ENOG4105DWF phosphomethylpyrimidine kinase GUY37_RS04915 ENOG4105C3J Cysteine desulfurase GUY37_RS04920 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GUY37_RS04925 ENOG4108IYU L-aspartate oxidase GUY37_RS04930 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GUY37_RS04935 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GUY37_RS04940 ENOG4107QQT Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GUY37_RS04955 ENOG4107QVP Dehydrogenase GUY37_RS04970 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GUY37_RS04975 ENOG4107ZYJ bioY protein GUY37_RS04980 ENOG4108JJB ABC transporter GUY37_RS05005 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GUY37_RS05025 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GUY37_RS05030 ENOG4108UJD 30S ribosomal protein S9 GUY37_RS05035 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GUY37_RS05055 ENOG4105BZ1 (ABC) transporter GUY37_RS05060 ENOG4105CS9 pantothenic acid kinase GUY37_RS05070 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) GUY37_RS05075 ENOG4105CH2 amidohydrolase GUY37_RS05090 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GUY37_RS05095 ENOG4108097 ATP-binding protein GUY37_RS05115 ENOG4105CPC Aldo Keto reductase GUY37_RS05125 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GUY37_RS05130 ENOG4108JW7 Maf-like protein GUY37_RS05135 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) GUY37_RS05150 ENOG4105DKT Transcriptional regulator GUY37_RS05170 ENOG4105DEI Mannitol dehydrogenase GUY37_RS05175 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) GUY37_RS05180 ENOG4105EKQ RNA-directed DNA polymerase GUY37_RS05185 ENOG4105K4H Nlp p60 protein GUY37_RS05200 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GUY37_RS05205 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GUY37_RS05210 ENOG4105EMF GntR family transcriptional regulator GUY37_RS05215 ENOG4105C6Z Gluconate GUY37_RS05220 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family GUY37_RS05225 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GUY37_RS05235 ENOG4105C3R Methionine synthase GUY37_RS05240 ENOG4106HWW Acyltransferase family GUY37_RS05250 ENOG4105C5H ABC transporter GUY37_RS05255 ENOG4105DIH basic membrane GUY37_RS05260 ENOG4108JQ9 ABC transporter GUY37_RS05265 ENOG4105UIB (ABC) transporter GUY37_RS05305 ENOG4105DRR Transcriptional regulator, GntR family GUY37_RS05315 ENOG4105DG4 malate L-lactate dehydrogenase GUY37_RS05320 ENOG4105CSH Transporter GUY37_RS05325 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GUY37_RS05330 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain GUY37_RS05395 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) GUY37_RS05400 ENOG4105CAK Cell division ATP-binding protein ftsE GUY37_RS05415 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) GUY37_RS05440 ENOG4105WH1 Two component transcriptional regulator luxr family GUY37_RS05450 ENOG4105CFN oxalyl-CoA decarboxylase GUY37_RS05460 ENOG4105C7K acetolactate synthase GUY37_RS05475 ENOG4105CIH Imidazole acetol-phosphate transaminase GUY37_RS05505 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GUY37_RS05515 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) GUY37_RS05540 ENOG4105E33 succinate dehydrogenase GUY37_RS05560 ENOG4105CJT Mannose-1-phosphate guanylyltransferase GUY37_RS05565 ENOG4107RM1 amidohydrolase GUY37_RS05575 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GUY37_RS05585 ENOG41061H0 Monooxygenase GUY37_RS05600 ENOG4108VHT MarR family transcriptional regulator GUY37_RS05605 ENOG4105CMV Succinyl-CoA synthetase subunit beta GUY37_RS05615 ENOG4105C5W Aldolase GUY37_RS05620 ENOG4105SHT UspA domain-containing protein GUY37_RS05625 ENOG4105CSH Transporter GUY37_RS05630 ENOG4105E98 transcriptional regulator DeoR family GUY37_RS05640 ENOG4105DM4 PTS System GUY37_RS05645 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GUY37_RS05650 ENOG410849S phosphocarrier protein (HPr) GUY37_RS05655 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) GUY37_RS05675 ENOG4105CUB amino acid GUY37_RS05725 ENOG4108JIK carboxylase GUY37_RS05730 ENOG4105P4J Allophanate hydrolase, subunit 1 GUY37_RS05735 ENOG4105CFM UPF0317 protein GUY37_RS05740 ENOG4105E7W lamb ycsf family protein GUY37_RS05745 ENOG4105C5A transporter GUY37_RS05760 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GUY37_RS05800 ENOG4108RVA ribokinase GUY37_RS05805 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GUY37_RS05820 ENOG4105CSV Glutaminase GUY37_RS05845 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GUY37_RS05860 ENOG41080R8 Conserved Protein GUY37_RS05865 ENOG4107QR9 Iron-sulfur cluster binding protein GUY37_RS05870 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GUY37_RS05880 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) GUY37_RS05915 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GUY37_RS05930 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GUY37_RS05940 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GUY37_RS05945 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GUY37_RS05950 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GUY37_RS05960 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GUY37_RS05970 ENOG4105D7W serine acetyltransferase GUY37_RS05980 ENOG4105DEN Luciferase family GUY37_RS05995 ENOG4105F9U Dehydrogenase GUY37_RS06000 ENOG4105C01 Dihydroxy-acid dehydratase GUY37_RS06035 ENOG4105FP9 thiamine pyrophosphate GUY37_RS06065 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GUY37_RS06070 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GUY37_RS06080 ENOG4105BZ1 (ABC) transporter GUY37_RS06085 ENOG4105BZ1 (ABC) transporter GUY37_RS06090 ENOG4105C7K acetolactate synthase GUY37_RS06095 ENOG4108ZP8 Acetolactate synthase small subunit GUY37_RS06100 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GUY37_RS06105 ENOG4105HHS UPF0256 protein GUY37_RS06110 ENOG4108JQ1 Dehydrogenase GUY37_RS06125 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GUY37_RS06130 ENOG4105CM2 brancheD-chain amino acid aminotransferase GUY37_RS06135 ENOG41079KZ Major Facilitator Superfamily GUY37_RS06160 ENOG4105EC3 peptidase S51, dipeptidase E GUY37_RS06175 ENOG4107Z60 histidine triad (HIT) protein GUY37_RS06190 ENOG4105CQ7 ATP-dependent helicase GUY37_RS06200 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GUY37_RS06225 ENOG4107WI4 Aldose-1-epimerase GUY37_RS06235 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) GUY37_RS06255 ENOG4105E98 transcriptional regulator DeoR family GUY37_RS06260 ENOG41069M3 Transcriptional regulator GUY37_RS06265 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GUY37_RS06270 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GUY37_RS06275 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GUY37_RS06285 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GUY37_RS06295 ENOG4105CPF Cell wall formation (By similarity) GUY37_RS06320 ENOG4106H78 methyltransferase GUY37_RS06335 ENOG4105DRP amino acid AbC transporter GUY37_RS06350 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GUY37_RS06365 ENOG41063DX 50S ribosomal protein L32 GUY37_RS06370 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GUY37_RS06375 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GUY37_RS06385 ENOG4105D7N magnesium and cobalt transport protein CorA GUY37_RS06395 ENOG4105C94 Transporter GUY37_RS06415 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GUY37_RS06430 ENOG4105K5M 30s ribosomal protein S16 GUY37_RS06435 ENOG41082KU UPF0109 protein GUY37_RS06440 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GUY37_RS06445 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GUY37_RS06455 ENOG4107QYR Signal peptidase i GUY37_RS06465 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GUY37_RS06475 ENOG41080R2 UPF0102 protein GUY37_RS06500 ENOG4105CE9 30S ribosomal protein S2 GUY37_RS06505 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GUY37_RS06510 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GUY37_RS06515 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GUY37_RS06520 ENOG4105KNE Phosphatidate cytidylyltransferase GUY37_RS06525 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GUY37_RS06540 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GUY37_RS06545 ENOG4105C1G acyl-Coa dehydrogenase GUY37_RS06550 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GUY37_RS06555 ENOG4105DZP Membrane-associated zinc metalloprotease GUY37_RS06560 ENOG4105FQP Beta-lactamase GUY37_RS06565 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GUY37_RS06585 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GUY37_RS06605 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) GUY37_RS06620 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) GUY37_RS06625 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GUY37_RS06655 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GUY37_RS06660 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GUY37_RS06665 ENOG4105C1V Peptidase, M16 GUY37_RS06675 ENOG4105F6U Short-chain dehydrogenase reductase Sdr GUY37_RS06680 ENOG4105D82 Glutamate dehydrogenase GUY37_RS06690 ENOG4105C7K acetolactate synthase GUY37_RS06695 ENOG4105C1G acyl-Coa dehydrogenase GUY37_RS06710 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GUY37_RS06730 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GUY37_RS06735 ENOG4105CN5 Metallo-Beta-Lactamase GUY37_RS06740 ENOG4105DAA L-lactate GUY37_RS06745 ENOG4107R9S Malate synthase GUY37_RS06760 ENOG4105D4T Citrate transporter GUY37_RS06770 ENOG4108MRH transcriptional regulatory protein GUY37_RS06795 ENOG4105CEV competence damage-inducible protein GUY37_RS06800 ENOG4105WBV Transcriptional regulator GUY37_RS06815 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) GUY37_RS06820 ENOG4105KC9 Modulates RecA activity (By similarity) GUY37_RS06825 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GUY37_RS06835 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GUY37_RS06840 ENOG4105D2S major facilitator superfamily GUY37_RS06845 ENOG4105DAE Methylenetetrahydrofolate reductase GUY37_RS06850 ENOG4105CNQ glycine cleavage T protein, aminomethyl transferase GUY37_RS06860 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) GUY37_RS06865 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) GUY37_RS06870 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GUY37_RS06880 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GUY37_RS06890 ENOG4105CIH Imidazole acetol-phosphate transaminase GUY37_RS06895 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GUY37_RS06905 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GUY37_RS06910 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GUY37_RS06920 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B GUY37_RS06925 ENOG4105CFC Transporter GUY37_RS06960 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GUY37_RS06965 ENOG4108BNZ Ribosomal protein L35 GUY37_RS06970 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GUY37_RS06975 ENOG4108RWN rrna methyltransferase GUY37_RS07005 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GUY37_RS07010 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GUY37_RS07015 ENOG4105CHR reductase GUY37_RS07065 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GUY37_RS07090 ENOG4107RSM transcriptional regulator GUY37_RS07125 ENOG4105CKI cobalamin synthesis protein GUY37_RS07140 ENOG4108FUF Transcriptional regulator, IclR family GUY37_RS07160 ENOG4107WUY phosphate acetyltransferase GUY37_RS07165 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GUY37_RS07170 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GUY37_RS07180 ENOG4105DND Transcriptional regulator GUY37_RS07185 ENOG4105CK7 Sodium proline symporter GUY37_RS07215 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GUY37_RS07225 ENOG4105C3U ABC transporter GUY37_RS07250 ENOG4105FDP GntR family transcriptional regulator GUY37_RS07255 ENOG4105MWK D-amino acid dehydrogenase, small subunit GUY37_RS07260 ENOG4105CFC Transporter GUY37_RS07265 ENOG4105J4Q Transcriptional regulator GUY37_RS07270 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 GUY37_RS07275 ENOG4108RTU Aldolase GUY37_RS07280 ENOG4105CXK mandelate racemase muconate lactonizing GUY37_RS07285 ENOG4105DJB Major Facilitator Superfamily GUY37_RS07305 ENOG4105C0D helicase GUY37_RS07355 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GUY37_RS07365 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) GUY37_RS07375 ENOG4105C8Y Acetylornithine aminotransferase GUY37_RS07380 ENOG4105DBV ornithine carbamoyltransferase GUY37_RS07385 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) GUY37_RS07390 ENOG4105CH7 arginosuccinase GUY37_RS07410 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GUY37_RS07450 ENOG4105C94 Transporter GUY37_RS07475 ENOG4105DSU hydrolase GUY37_RS07490 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GUY37_RS07495 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GUY37_RS07530 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GUY37_RS07535 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GUY37_RS07540 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GUY37_RS07550 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) GUY37_RS07555 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) GUY37_RS07570 ENOG4105CAT Cytidine monophosphate kinase GUY37_RS07575 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GUY37_RS07580 ENOG4105DSF transport protein GUY37_RS07585 ENOG4107RTD sua5 ycio yrdc ywlc family protein GUY37_RS07590 ENOG4108IV0 ABC, transporter GUY37_RS07595 ENOG4105C0Z ABC transporter GUY37_RS07600 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GUY37_RS07605 ENOG4105C32 Amino acid ABC transporter (Permease) GUY37_RS07615 ENOG4105CHR reductase GUY37_RS07620 ENOG4105CHU acetyl-coa acetyltransferase GUY37_RS07630 ENOG4105UQX Mate efflux family protein GUY37_RS07670 ENOG4108UW8 fha domain-containing protein GUY37_RS07680 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase GUY37_RS07710 ENOG4107VJY DNA polymerase GUY37_RS07735 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GUY37_RS07740 ENOG4108V6E Cell division protein mraZ GUY37_RS07745 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GUY37_RS07755 ENOG4105CJN penicillin-binding protein GUY37_RS07760 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GUY37_RS07765 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) GUY37_RS07770 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GUY37_RS07775 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GUY37_RS07785 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GUY37_RS07790 ENOG4105DFU Cell wall formation (By similarity) GUY37_RS07800 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GUY37_RS07805 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GUY37_RS07810 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) GUY37_RS07840 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GUY37_RS07845 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) GUY37_RS07865 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GUY37_RS07870 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase GUY37_RS07875 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GUY37_RS07880 ENOG4105D0M Protease HtpX homolog GUY37_RS07890 ENOG4105C4M (Ubiquinol oxidase) subunit I GUY37_RS07895 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GUY37_RS07900 ENOG4108JJ9 ABC, transporter GUY37_RS07910 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GUY37_RS07930 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) GUY37_RS07950 ENOG4107VEG TrkA-N domain protein GUY37_RS07955 ENOG4105C0X amino acid GUY37_RS07960 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GUY37_RS07970 ENOG4107QM5 aconitate hydratase GUY37_RS07975 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GUY37_RS07990 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GUY37_RS07995 ENOG4105C1Q protoporphyrinogen oxidase GUY37_RS08000 ENOG4107JTW chlorite dismutase GUY37_RS08010 ENOG4105K56 Transcriptional regulator GUY37_RS08020 ENOG4105E0X reductase GUY37_RS08035 ENOG4105NX3 Membrane GUY37_RS08065 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GUY37_RS08070 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) GUY37_RS08075 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GUY37_RS08085 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) GUY37_RS08105 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GUY37_RS08115 ENOG4105ENR peptidase, M24 GUY37_RS08140 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein GUY37_RS08145 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GUY37_RS08175 ENOG4107H3J ribonuclease GUY37_RS08180 ENOG4107T5V SNARE associated Golgi GUY37_RS08185 ENOG4105CHF Glutathione S-transferase GUY37_RS08195 ENOG4105C8T Leucyl-tRNA synthetase GUY37_RS08200 ENOG4107RA1 nh(3)-dependent nad( ) synthetase GUY37_RS08210 ENOG4105C6Y Udp-glucose 6-dehydrogenase GUY37_RS08215 ENOG4105EPR degv family GUY37_RS08235 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) GUY37_RS08250 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GUY37_RS08275 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) GUY37_RS08280 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GUY37_RS08285 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GUY37_RS08295 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GUY37_RS08305 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GUY37_RS08345 ENOG4105C22 threonyL-tRNA synthetase GUY37_RS08355 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein GUY37_RS08365 ENOG4105CDY transcriptional regulatory protein GUY37_RS08370 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) GUY37_RS08375 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GUY37_RS08380 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GUY37_RS08390 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GUY37_RS08395 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GUY37_RS08400 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GUY37_RS08410 ENOG4105C99 atpase involved in dna repair GUY37_RS08420 ENOG4105CUT histidyl-tRNA synthetase GUY37_RS08425 ENOG4105C9M aspartyl-trna synthetase GUY37_RS08440 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GUY37_RS08445 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GUY37_RS08450 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) GUY37_RS08455 ENOG4105HHA aminodeoxychorismate lyase GUY37_RS08460 ENOG4105E2X shikimate dehydrogenase GUY37_RS08470 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GUY37_RS08475 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GUY37_RS08480 ENOG4105D49 3-dehydroquinate synthase GUY37_RS08485 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GUY37_RS08490 ENOG410803B Involved in the transcription termination process (By similarity) GUY37_RS08495 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) GUY37_RS08500 ENOG4105CXT aspartate transcarbamylase GUY37_RS08505 ENOG4105CD3 dihydroorotase GUY37_RS08515 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GUY37_RS08520 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GUY37_RS08525 ENOG4105SKN orotidine 5''-phosphate decarboxylase GUY37_RS08530 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GUY37_RS08535 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GUY37_RS08540 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) GUY37_RS08550 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GUY37_RS08560 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GUY37_RS08570 ENOG4105DJV ribulose-phosphate 3-epimerase GUY37_RS08580 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase GUY37_RS08585 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) GUY37_RS08605 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GUY37_RS08610 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GUY37_RS08630 ENOG4105DK0 Indole-3-glycerol phosphate synthase GUY37_RS08635 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GUY37_RS08640 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) GUY37_RS08645 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GUY37_RS08650 ENOG4105CBC glutamate synthase GUY37_RS08660 ENOG4105CA9 Pyruvate kinase GUY37_RS08665 ENOG4107R6U sodium dicarboxylate symporter GUY37_RS08670 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GUY37_RS08685 ENOG4105KA0 thioesterase Superfamily protein GUY37_RS08700 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GUY37_RS08710 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GUY37_RS08715 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GUY37_RS08735 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GUY37_RS08740 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GUY37_RS08745 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GUY37_RS08750 ENOG4105CHW UPF0052 protein GUY37_RS08755 ENOG4105CIE May be required for sporulation (By similarity) GUY37_RS08760 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GUY37_RS08765 ENOG4105BZA Phosphoglycerate kinase GUY37_RS08770 ENOG4105CP7 Triose-phosphate isomerase GUY37_RS08785 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GUY37_RS08800 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GUY37_RS08835 ENOG4105JRK feS assembly protein SufD GUY37_RS08845 ENOG4105C3K feS assembly ATPase SufC GUY37_RS08855 ENOG4108UNV SUF system FeS assembly protein, NifU family GUY37_RS08860 ENOG4105VG1 fes assembly suf system protein GUY37_RS08865 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GUY37_RS08870 ENOG4105C5H ABC transporter GUY37_RS08890 ENOG4105CHR reductase GUY37_RS08905 ENOG4105EAC phosphoserine phosphatase GUY37_RS08915 ENOG4105DKW ABC transporter GUY37_RS08925 ENOG4105FCS tRNA rRNA methyltransferase GUY37_RS08930 ENOG4108XFF GUY37_RS08935 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GUY37_RS08940 ENOG4105NRA 50s ribosomal protein l31 type b GUY37_RS08945 ENOG4105DWF phosphomethylpyrimidine kinase GUY37_RS08950 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GUY37_RS08975 ENOG4105C0B DNA polymerase III (alpha subunit) GUY37_RS08980 ENOG4108IQK o-acetylhomoserine GUY37_RS08985 ENOG4105DWV Homoserine O-trans-acetylase GUY37_RS08990 ENOG4105C1G acyl-Coa dehydrogenase GUY37_RS09000 ENOG4105CHU acetyl-coa acetyltransferase GUY37_RS09005 ENOG4105CHR reductase GUY37_RS09040 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GUY37_RS09045 ENOG4105CPC Aldo Keto reductase GUY37_RS09065 ENOG4105C8N cysteinyl-tRNA synthetase GUY37_RS09095 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) GUY37_RS09105 ENOG4105E5F proteasome GUY37_RS09110 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) GUY37_RS09115 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) GUY37_RS09120 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) GUY37_RS09125 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) GUY37_RS09145 ENOG4108FFZ Transcriptional regulator GUY37_RS09160 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GUY37_RS09170 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GUY37_RS09175 ENOG4105HFS 5'-3' exonuclease GUY37_RS09185 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) GUY37_RS09190 ENOG4105Q70 GUY37_RS09205 ENOG4105K6T rare lipoprotein A GUY37_RS09215 ENOG4105D5Q Arginine ornithine antiporter GUY37_RS09230 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GUY37_RS09270 ENOG4105CH2 amidohydrolase GUY37_RS09275 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GUY37_RS09280 ENOG41090A1 ferritin GUY37_RS09300 ENOG4105XT2 Transcriptional regulator GUY37_RS09310 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GUY37_RS09315 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) GUY37_RS09350 ENOG4108I0Q anthranilate phosphoribosyltransferase GUY37_RS09355 ENOG4105CCU oxidase (Subunit III) GUY37_RS09360 ENOG4107UDY cytochrome C GUY37_RS09365 ENOG4107EUI c reductase, iron-sulfur GUY37_RS09370 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GUY37_RS09390 ENOG4105BZ9 Cytochrome C oxidase, subunit I GUY37_RS09395 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) GUY37_RS09400 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) GUY37_RS09420 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) GUY37_RS09425 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GUY37_RS09445 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) GUY37_RS09450 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) GUY37_RS09465 ENOG4105C5F glutamine synthetase GUY37_RS09475 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) GUY37_RS09480 ENOG4105C5F glutamine synthetase GUY37_RS09495 ENOG4105FDP GntR family transcriptional regulator GUY37_RS09505 ENOG4105DFK Polyphosphate glucokinase GUY37_RS09525 ENOG4105EGD dinuclear metal center protein, YbgI family GUY37_RS09585 ENOG4107ZUX Histidine triad (HIT) protein GUY37_RS09600 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GUY37_RS09615 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GUY37_RS09620 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GUY37_RS09625 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GUY37_RS09700 ENOG4105W1Y Transcriptional regulator GUY37_RS09720 ENOG4105CG5 Glycosyl transferase (Group 1 GUY37_RS09725 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) GUY37_RS09735 ENOG4105DRP amino acid AbC transporter GUY37_RS09740 ENOG4108Q1T ABC transporter GUY37_RS09745 ENOG4107UBR Extracellular solute-binding protein family 3 GUY37_RS09750 ENOG4105CDA abc transporter atp-binding protein GUY37_RS09755 ENOG4105CEY Amp-dependent synthetase and ligase GUY37_RS09780 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GUY37_RS09790 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GUY37_RS09815 ENOG4105DUX Transporter GUY37_RS09825 ENOG41082T9 Membrane GUY37_RS09870 ENOG4105DFA alanine racemase domain protein GUY37_RS09880 ENOG4108VW9 Membrane GUY37_RS09895 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme GUY37_RS09900 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) GUY37_RS09950 ENOG4105SC1 monovalent cation H antiporter subunit E GUY37_RS09955 ENOG4108JPZ Monovalent cation H antiporter subunit D GUY37_RS09960 ENOG4105MKQ Monovalent cation H antiporter subunit C GUY37_RS09965 ENOG4105C8S subunit m GUY37_RS09990 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GUY37_RS10000 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) GUY37_RS10005 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GUY37_RS10010 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GUY37_RS10015 ENOG4105K46 50S ribosomal protein l27 GUY37_RS10020 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GUY37_RS10030 ENOG4105BZG amino acid carrier protein GUY37_RS10040 ENOG4105C03 ribonuclease GUY37_RS10050 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GUY37_RS10060 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GUY37_RS10080 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GUY37_RS10090 ENOG4105C57 major facilitator superfamily GUY37_RS10095 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GUY37_RS10100 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GUY37_RS10105 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GUY37_RS10110 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GUY37_RS10135 ENOG4108YZG isomerase GUY37_RS10140 ENOG4105MC2 DSBA oxidoreductase GUY37_RS10150 ENOG4105D8X mechanosensitive ion channel GUY37_RS10170 ENOG4105C29 acyl-CoA thioesterase GUY37_RS10220 ENOG4105CHU acetyl-coa acetyltransferase GUY37_RS10230 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) GUY37_RS10245 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GUY37_RS10255 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GUY37_RS10260 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GUY37_RS10265 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GUY37_RS10270 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GUY37_RS10275 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GUY37_RS10280 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) GUY37_RS10285 ENOG4105ZA1 atp synthase GUY37_RS10290 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) GUY37_RS10300 ENOG4105ESV Glycosyl transferase, family 4 GUY37_RS10310 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GUY37_RS10315 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GUY37_RS10325 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GUY37_RS10335 ENOG4105D6E homoserine dehydrogenase GUY37_RS10340 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GUY37_RS10345 ENOG4105C75 arginyL-tRNA synthetase GUY37_RS10350 ENOG4105DJ2 Major Facilitator Superfamily GUY37_RS10355 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GUY37_RS10360 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GUY37_RS10390 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GUY37_RS10405 ENOG4105EMN RNA polymerase sigma factor GUY37_RS10415 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GUY37_RS10420 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GUY37_RS10425 ENOG4107TK4 histidinol-phosphate phosphatase GUY37_RS10475 ENOG4105MEW serine threonine protein phosphatase GUY37_RS10495 ENOG4107QIV Cytochrome c biogenesis protein GUY37_RS10520 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GUY37_RS10550 ENOG4105VPX protein, conserved in bacteria GUY37_RS10555 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GUY37_RS10580 ENOG4105D65 subunit l GUY37_RS10585 ENOG4105C8S subunit m GUY37_RS10590 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GUY37_RS10600 ENOG41090UD (LipO)protein GUY37_RS10625 ENOG4105ETS cytosine purines uracil thiamine allantoin GUY37_RS10655 ENOG4107QPD alcohol dehydrogenase GUY37_RS10670 ENOG4105DJZ UPF0182 protein GUY37_RS10675 ENOG41063PX domain protein GUY37_RS10715 ENOG4105C4R Atp-dependent dna helicase GUY37_RS10725 ENOG4108IG5 Transcriptional regulator GUY37_RS10740 ENOG4105C1J atp-dependent rna helicase GUY37_RS10750 ENOG4107T6F Xaa-Pro aminopeptidase GUY37_RS10755 ENOG4105KXX peptidase s58 dmpa GUY37_RS10765 ENOG4105CJW magnesium transporter GUY37_RS10785 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) GUY37_RS10795 ENOG4107ZBN O-methyltransferase GUY37_RS10820 ENOG4108URH decarboxylase GUY37_RS10845 ENOG4108Z4U Ferredoxin GUY37_RS10855 ENOG41073R8 VanW family GUY37_RS10860 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) GUY37_RS10865 ENOG4105CI3 gtp-binding protein typa GUY37_RS10870 ENOG4108JQ6 ABC transporter GUY37_RS10875 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GUY37_RS10895 ENOG4105C5X domain protein GUY37_RS10900 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GUY37_RS10905 ENOG4105C8P )-transporter GUY37_RS10915 ENOG4107104 thymidine kinase GUY37_RS10925 ENOG41060H3 Protein of unknown function (DUF1049) GUY37_RS10940 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GUY37_RS10950 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) GUY37_RS10970 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) GUY37_RS10980 ENOG4105K5B UPF0225 protein GUY37_RS11000 ENOG4105CAY ferredoxin--nadp reductase GUY37_RS11015 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) GUY37_RS11020 ENOG4105CGH 5'-nucleotidase GUY37_RS11070 ENOG4105CKW Inner membrane protein yedI GUY37_RS11075 ENOG4105E0A ABC, transporter GUY37_RS11080 ENOG4105TVJ transport system, permease GUY37_RS11085 ENOG4105DQ5 transport system permease protein GUY37_RS11100 ENOG4105EV9 Alpha Beta Hydrolase GUY37_RS11110 ENOG4105J76 Periplasmic binding protein GUY37_RS11115 ENOG4108IQI permease GUY37_RS11120 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) GUY37_RS11135 ENOG4105WH1 Two component transcriptional regulator luxr family GUY37_RS11150 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GUY37_RS11155 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GUY37_RS11170 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GUY37_RS11190 ENOG4107104 thymidine kinase GUY37_RS11225 ENOG4108JJB ABC transporter GUY37_RS11285 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GUY37_RS11305 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ GUY37_RS11325 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GUY37_RS11330 ENOG4105VDM plasmid maintenance system antidote protein, xre family GUY37_RS11340 ENOG4105C3G gtp-binding protein GUY37_RS11345 ENOG4105CGY Dna recombination protein GUY37_RS11350 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GUY37_RS11355 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GUY37_RS11360 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GUY37_RS11380 ENOG4105C9Q fumarate hydratase class II GUY37_RS11385 ENOG4108IAB Phoh family GUY37_RS11390 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GUY37_RS11405 ENOG4105T1M mycothiol conjugate amidase mca GUY37_RS11415 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GUY37_RS11430 ENOG4107WR6 Maf-like protein GUY37_RS11435 ENOG4108JIK carboxylase GUY37_RS11440 ENOG4105CHP RNA polymerase GUY37_RS11455 ENOG4108Z0R Transferase GUY37_RS11470 ENOG4105C7I Dehydrogenase GUY37_RS11515 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GUY37_RS11525 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea GUY37_RS11535 ENOG4108T3R lipoprotein lpqB GUY37_RS11545 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GUY37_RS11565 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GUY37_RS11585 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) GUY37_RS11590 ENOG4107QKV phosphomannomutase GUY37_RS11615 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GUY37_RS11645 ENOG4105EIP mannose-6-phosphate isomerase GUY37_RS11650 ENOG4105K4H Nlp p60 protein GUY37_RS11655 ENOG4108KGH TRANSCRIPTIONal GUY37_RS11685 ENOG410870F Cyclic nucleotide-binding protein GUY37_RS11695 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GUY37_RS11710 ENOG4105D8K carboxyl transferase GUY37_RS11735 ENOG4105CZM Major Facilitator GUY37_RS11745 ENOG4108WYP Transcriptional regulator GUY37_RS11755 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease GUY37_RS11760 ENOG41079KZ Major Facilitator Superfamily GUY37_RS11770 ENOG4105CSH Transporter GUY37_RS11775 ENOG4105MXW flavin reductase domain protein, FMN-binding GUY37_RS11785 ENOG4107ZXU DSBA oxidoreductase GUY37_RS11800 ENOG4105KT7 mgtC SapB transporter GUY37_RS11825 ENOG4105WH1 Two component transcriptional regulator luxr family GUY37_RS11830 ENOG4105BZU Histidine kinase GUY37_RS11855 ENOG4105E6M Sulphatase-modifying factor protein GUY37_RS11865 ENOG4108T9J Cdp-alcohol phosphatidyltransferase GUY37_RS11870 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GUY37_RS11885 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GUY37_RS11910 ENOG4105BZU Histidine kinase GUY37_RS11915 ENOG4105WH1 Two component transcriptional regulator luxr family GUY37_RS11920 ENOG4105CSH Transporter GUY37_RS11930 ENOG4105CR8 Transcriptional regulator GUY37_RS11950 ENOG4105E9F Enoyl-CoA hydratase GUY37_RS11955 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GUY37_RS11960 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) GUY37_RS11975 ENOG4105CSU acyl-Coa dehydrogenase GUY37_RS12000 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) GUY37_RS12010 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase GUY37_RS12025 ENOG4105C6Z Gluconate GUY37_RS12030 ENOG4105G63 Type III effector Hrp-dependent GUY37_RS12035 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) GUY37_RS12040 ENOG4105MVE transcriptional regulator GUY37_RS12045 ENOG4105CSH Transporter GUY37_RS12070 ENOG4108R85 Short chain dehydrogenase GUY37_RS12080 ENOG4105CEY Amp-dependent synthetase and ligase GUY37_RS12100 ENOG4105E0A ABC, transporter GUY37_RS12105 ENOG4105J76 Periplasmic binding protein GUY37_RS12110 ENOG4105S6R Iron-hydroxamate transporter permease subunit GUY37_RS12120 ENOG4105C7F AcnD-accessory protein PrpF GUY37_RS12125 ENOG4107RSM transcriptional regulator GUY37_RS12130 ENOG4105C5Q Transcriptional regulator GUY37_RS12135 ENOG4105DWT malate dehydrogenase (quinone) GUY37_RS12145 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GUY37_RS12150 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GUY37_RS12155 ENOG4105C3U ABC transporter GUY37_RS12160 ENOG4108JQ7 (ABC) transporter GUY37_RS12165 ENOG4105DYB Isoaspartyl dipeptidase GUY37_RS12170 ENOG4105DFD Na H antiporter GUY37_RS12175 ENOG4108WFR AraC Family Transcriptional Regulator GUY37_RS12190 ENOG4105CK7 Sodium proline symporter GUY37_RS12210 ENOG4105C26 Dehydrogenase GUY37_RS12215 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GUY37_RS12225 ENOG4105CFC Transporter GUY37_RS12230 ENOG4105CZA synthase GUY37_RS12235 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) GUY37_RS12245 ENOG4105CQ7 ATP-dependent helicase GUY37_RS12250 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) GUY37_RS12285 ENOG4105CSR polyphosphate kinase 2 GUY37_RS12305 ENOG4105KVH Transcriptional regulator GUY37_RS12345 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GUY37_RS12360 ENOG41067RQ csbd family GUY37_RS12380 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GUY37_RS12385 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GUY37_RS12395 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GUY37_RS12400 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GUY37_RS12455 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GUY37_RS12465 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GUY37_RS12480 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GUY37_RS12485 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GUY37_RS12490 ENOG4108RQ5 Beta-lactamase domain-containing protein GUY37_RS12500 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) GUY37_RS12525 ENOG4107R37 Glutamate dehydrogenase GUY37_RS12565 ENOG4105C1G acyl-Coa dehydrogenase GUY37_RS12590 ENOG4105C31 Tryptophanyl-tRNA synthetase GUY37_RS12595 ENOG4105D22 carbon starvation protein GUY37_RS12615 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GUY37_RS12620 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GUY37_RS12650 ENOG4105CK7 Sodium proline symporter GUY37_RS12655 ENOG4108ZT0 50S ribosomal protein l17 GUY37_RS12660 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GUY37_RS12665 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GUY37_RS12670 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GUY37_RS12675 ENOG41067V7 50S ribosomal protein L36 GUY37_RS12680 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GUY37_RS12685 ENOG4105C87 Aminotransferase class I and II GUY37_RS12700 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GUY37_RS12705 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GUY37_RS12720 ENOG410849U 50S ribosomal protein L30 GUY37_RS12725 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GUY37_RS12730 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) GUY37_RS12735 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GUY37_RS12740 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GUY37_RS12745 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GUY37_RS12750 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) GUY37_RS12755 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GUY37_RS12760 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GUY37_RS12765 ENOG41082SA 50s ribosomal protein l29 GUY37_RS12770 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GUY37_RS12775 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GUY37_RS12780 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GUY37_RS12785 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GUY37_RS12795 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) GUY37_RS12800 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GUY37_RS12805 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GUY37_RS12810 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) GUY37_RS12815 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GUY37_RS12820 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GUY37_RS12825 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GUY37_RS12830 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GUY37_RS12840 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) GUY37_RS12850 ENOG4105BZU Histidine kinase GUY37_RS12855 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GUY37_RS12860 ENOG4105EDW glycosyl transferase, family 39 GUY37_RS12865 ENOG4105CKK Glycosyl transferase, family 2 GUY37_RS12880 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GUY37_RS12885 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GUY37_RS12890 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GUY37_RS12910 ENOG410836F Transposase GUY37_RS12930 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GUY37_RS12935 ENOG4108VZM 50s ribosomal protein L10 GUY37_RS12945 ENOG4105C26 Dehydrogenase GUY37_RS12950 ENOG4107RR1 TRANSCRIPTIONal GUY37_RS12955 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) GUY37_RS12960 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GUY37_RS12985 ENOG4107R4N Cell wall formation (By similarity) GUY37_RS12990 ENOG410900P UPF0336 protein GUY37_RS13010 ENOG41063NY Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GUY37_RS13015 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GUY37_RS13040 ENOG4105CH2 amidohydrolase GUY37_RS13045 ENOG4105CI2 imidazolone-5-propionate hydrolase GUY37_RS13085 ENOG4105E4C Lytic transglycosylase catalytic GUY37_RS13140 ENOG4105E3B Multicopper oxidase GUY37_RS13150 ENOG4107TPS domain protein GUY37_RS13160 ENOG4105VPX protein, conserved in bacteria GUY37_RS13165 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) GUY37_RS13170 ENOG41085GJ domain protein GUY37_RS13180 ENOG4108VCT Sulfite exporter TauE/SafE GUY37_RS13185 ENOG4108C33 Resolvase GUY37_RS13195 ENOG4108C33 Resolvase GUY37_RS13200 ENOG4108Z7F N-acetyltransferase GUY37_RS13205 ENOG4105HS2 Arsenate reductase GUY37_RS13225 ENOG4105H3G oxidoreductase GUY37_RS13245 ENOG4105K63 Thioredoxin GUY37_RS13250 ENOG4105C3M thioredoxin reductase GUY37_RS13280 ENOG4107QIV Cytochrome c biogenesis protein GUY37_RS13480 ENOG4107T6V glycerophosphoryl diester phosphodiesterase GUY37_RS13505 ENOG4108VPT UPF0234 protein GUY37_RS13515 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GUY37_RS13535 ENOG4107S21 permease GUY37_RS13550 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GUY37_RS13555 ENOG4105E4F Isochorismate synthase GUY37_RS13560 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) GUY37_RS13575 ENOG4107TCW O-succinylbenzoate synthase GUY37_RS13580 ENOG4107SIQ Naphthoate synthase GUY37_RS13600 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GUY37_RS13605 ENOG4105CRE cytochrome C GUY37_RS13610 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) GUY37_RS13615 ENOG4107QIV Cytochrome c biogenesis protein GUY37_RS13625 ENOG4108RH7 phosphoglycerate mutase GUY37_RS13630 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GUY37_RS13640 ENOG4105D52 delta-aminolevulinic acid dehydratase GUY37_RS13650 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GUY37_RS13655 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) GUY37_RS13670 ENOG4105DGU Histone deacetylase GUY37_RS13675 ENOG4105CZN Potassium uptake protein GUY37_RS13680 ENOG4107ZYR domain protein GUY37_RS13690 ENOG4107QN1 sodium solute GUY37_RS13705 ENOG4105II7 pyrroline-5-carboxylate reductase GUY37_RS13710 ENOG4105EY0 Xylose isomerase domain protein TIM barrel GUY37_RS13720 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GUY37_RS13725 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GUY37_RS13730 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GUY37_RS13735 ENOG4107R33 ppx gppa phosphatase GUY37_RS13740 ENOG4108UKI Enoyl-CoA hydratase GUY37_RS13745 ENOG4105BZN citrate synthase GUY37_RS13750 ENOG4105CR4 methylisocitrate lyase GUY37_RS13770 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein GUY37_RS13775 ENOG4108JJB ABC transporter GUY37_RS13800 ENOG4105DDW LysR family Transcriptional regulator GUY37_RS13810 ENOG4105C26 Dehydrogenase GUY37_RS13820 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GUY37_RS13840 ENOG4105CEN a g-specific adenine glycosylase GUY37_RS13870 ENOG4105CRK lysyL-tRNA synthetase GUY37_RS13895 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GUY37_RS13905 ENOG4105EUJ GTP cyclohydrolase i GUY37_RS13910 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GUY37_RS13915 ENOG4108UGV hypoxanthine phosphoribosyltransferase GUY37_RS13920 ENOG4105DJ2 Major Facilitator Superfamily GUY37_RS13930 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GUY37_RS13970 ENOG4105C0R drug resistance transporter emrb qaca subfamily GUY37_RS13980 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GUY37_RS13990 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GUY37_RS14000 ENOG4105DJG MaoC domain protein dehydratase GUY37_RS14005 ENOG4105CVJ phosphoglycerate mutase GUY37_RS14015 ENOG41082BM Transcriptional regulator, arsr family GUY37_RS14025 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GUY37_RS14030 ENOG4105C1G acyl-Coa dehydrogenase GUY37_RS14040 ENOG4107QX3 carboxylase GUY37_RS14055 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GUY37_RS14060 ENOG4105CHU acetyl-coa acetyltransferase GUY37_RS14085 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GUY37_RS14100 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GUY37_RS14110 ENOG4108I5C dEAD DEAH box helicase GUY37_RS14160 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GUY37_RS14170 ENOG4105P8F nudix hydrolase GUY37_RS14205 ENOG4105BZ4 penicillin-binding protein GUY37_RS14215 ENOG4105CC5 ABC transporter GUY37_RS14220 ENOG4105DIK (ABC) transporter GUY37_RS14235 ENOG4105CFH Aspartokinase GUY37_RS14240 ENOG4105VMP Transcriptional regulator GUY37_RS14250 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GUY37_RS14295 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GUY37_RS14345 ENOG4105ME7 Membrane GUY37_RS14350 ENOG4105CHP RNA polymerase GUY37_RS14365 ENOG4108Z0Z intracellular protease Pfpi family GUY37_RS14395 ENOG4108MES Periplasmic binding protein GUY37_RS14400 ENOG4105WBV Transcriptional regulator GUY37_RS14410 ENOG4105WH1 Two component transcriptional regulator luxr family GUY37_RS14415 ENOG4105BZU Histidine kinase GUY37_RS14420 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GUY37_RS14425 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GUY37_RS14440 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GUY37_RS14445 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GUY37_RS14470 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GUY37_RS14480 ENOG4105DEN Luciferase family GUY37_RS14520 ENOG4105DGW oligopeptidase A GUY37_RS14530 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) GUY37_RS14535 ENOG4107QK5 Homocysteine s-methyltransferase GUY37_RS14540 ENOG4105CQB FAD linked oxidase domain protein GUY37_RS14545 ENOG4105CIH Imidazole acetol-phosphate transaminase GUY37_RS14550 ENOG4105DWT malate dehydrogenase (quinone) GUY37_RS14570 ENOG4107HP6 Transcriptional regulator GUY37_RS14595 ENOG4105BZW Glycerate kinase GUY37_RS14615 ENOG41060W2 glyoxylate carboligase GUY37_RS14620 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GUY37_RS14625 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) GUY37_RS14630 ENOG4107QUY Guanine deaminase GUY37_RS14650 ENOG4105C7N Xanthine uracil vitamin C permease GUY37_RS14660 ENOG4108Z6B deaminase GUY37_RS14670 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GUY37_RS14675 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GUY37_RS14715 ENOG4105C26 Dehydrogenase GUY37_RS14725 ENOG4105ERH Fumarylacetoacetate hydrolase GUY37_RS14730 ENOG4105CSH Transporter GUY37_RS14735 ENOG4105QPS Monooxygenase GUY37_RS14775 ENOG4105C7F AcnD-accessory protein PrpF GUY37_RS14780 ENOG4105D2S major facilitator superfamily GUY37_RS14825 ENOG4107STQ Multicopper oxidase GUY37_RS14835 ENOG4105ENE Histidine kinase GUY37_RS14855 ENOG4108UVJ appr-1-p processing domain protein GUY37_RS14870 ENOG4105CUC YeeE YedE family protein GUY37_RS14875 ENOG4105DXD 2-methylcitrate dehydratase GUY37_RS14920 ENOG4105C83 adenylosuccinate lyase GUY37_RS14925 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase GUY37_RS14930 ENOG4105F27 Major Facilitator GUY37_RS14940 ENOG4105CSH Transporter GUY37_RS14945 ENOG4106PMH Extracellular solute-binding protein family 3 GUY37_RS14950 ENOG4105EAD ABC transporter GUY37_RS14960 ENOG4105CTU Proline racemase GUY37_RS14965 ENOG4105CXN decarboxylase GUY37_RS14970 ENOG4105C7K acetolactate synthase GUY37_RS14980 ENOG4108JPW Aminotransferase GUY37_RS14985 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GUY37_RS14990 ENOG4108Z66 YbaK ebsC protein GUY37_RS15015 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GUY37_RS15020 ENOG4108W6C Dehydrogenase GUY37_RS15035 ENOG4107QNK )-transporter GUY37_RS15040 ENOG4105SHT UspA domain-containing protein GUY37_RS15050 ENOG4105CJW magnesium transporter GUY37_RS15055 ENOG4105BZ1 (ABC) transporter GUY37_RS15060 ENOG4105BZ1 (ABC) transporter GUY37_RS15070 ENOG4105CI2 imidazolone-5-propionate hydrolase GUY37_RS15075 ENOG4105C1G acyl-Coa dehydrogenase GUY37_RS15080 ENOG4106NZI LysR family Transcriptional regulator GUY37_RS15085 ENOG4105C26 Dehydrogenase GUY37_RS15100 ENOG4105W1N transcriptional regulator GUY37_RS15120 ENOG4105CPC Aldo Keto reductase GUY37_RS15130 ENOG4105H3G oxidoreductase GUY37_RS15150 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GUY37_RS15155 ENOG4105CH6 catalase GUY37_RS15170 ENOG4105CSH Transporter GUY37_RS15205 ENOG41086D8 Transcriptional regulator GUY37_RS15235 ENOG4105CXB phosphoribosylaminoimidazole synthetase GUY37_RS15260 ENOG4105C26 Dehydrogenase GUY37_RS15275 ENOG4105C12 Phosphoribosylglycinamide synthetase GUY37_RS15295 ENOG4105CI2 imidazolone-5-propionate hydrolase GUY37_RS15300 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GUY37_RS15315 ENOG4105D38 putrescine abc transporter GUY37_RS15320 ENOG4105CJP fad dependent oxidoreductase GUY37_RS15325 ENOG410839H phosphoribosylformylglycinamidine synthase GUY37_RS15330 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I GUY37_RS15415 ENOG4105ECP epimerase GUY37_RS15420 ENOG4105C72 UPF0176 protein GUY37_RS15425 ENOG4107QIK phosphoribosylformylglycinamidine synthase GUY37_RS15430 ENOG4105IIP Membrane GUY37_RS15450 ENOG4105CBG Sulfatase GUY37_RS15455 ENOG4105C94 Transporter GUY37_RS15465 ENOG410814C multidrug resistance protein GUY37_RS15515 ENOG4105C57 major facilitator superfamily GUY37_RS15530 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family GUY37_RS15535 ENOG4105CPQ Dehydrogenase GUY37_RS15555 ENOG4105DJ2 Major Facilitator Superfamily GUY37_RS15570 ENOG4105CAQ asparagine synthetase GUY37_RS15575 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system GUY37_RS15585 ENOG4108IJ8 ABC transporter GUY37_RS15590 ENOG4105R40 Glycine betaine carnitine choline GUY37_RS15595 ENOG4105CSV Glutaminase GUY37_RS15605 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase GUY37_RS15620 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GUY37_RS15640 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GUY37_RS15655 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GUY37_RS15660 ENOG4105WH1 Two component transcriptional regulator luxr family GUY37_RS15665 ENOG4105BZU Histidine kinase GUY37_RS15675 ENOG4107SQD Transcriptional regulator, GntR family GUY37_RS15685 ENOG4107JBM CrcB-like protein GUY37_RS15690 ENOG41083TI Protein CrcB homolog GUY37_RS15700 ENOG41062D9 Histidine kinase GUY37_RS15705 ENOG4105ETX regulatoR GUY37_RS15720 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GUY37_RS15725 ENOG4105YVS arsR family transcriptional regulator GUY37_RS15760 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GUY37_RS15770 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) GUY37_RS15775 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GUY37_RS15790 ENOG4108ZHJ Organic hydroperoxide resistance protein GUY37_RS15820 ENOG4106NZI LysR family Transcriptional regulator GUY37_RS15830 ENOG4105CAY ferredoxin--nadp reductase GUY37_RS15865 ENOG4105YB8 TM2 domain containing protein GUY37_RS15870 ENOG4107QQR Sporulation GUY37_RS15875 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GUY37_RS15920 ENOG4107QJT sodium dicarboxylate symporter GUY37_RS15965 ENOG4105CHR reductase GUY37_RS16000 ENOG4106A3M Cytochrome p-450 GUY37_RS16010 ENOG4108PTX LysR family Transcriptional regulator GUY37_RS16020 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase GUY37_RS16025 ENOG4105CMD Transcriptional regulator, GntR family GUY37_RS16040 ENOG4105MSY salicylate hydroxylase GUY37_RS16055 ENOG4105CHU acetyl-coa acetyltransferase GUY37_RS16065 ENOG4105D94 Major Facilitator Superfamily GUY37_RS16070 ENOG4105CSH Transporter GUY37_RS16095 ENOG4105C5X domain protein GUY37_RS16100 ENOG4105D2S major facilitator superfamily GUY37_RS16110 ENOG4105U5Y Transcriptional regulator GUY37_RS16135 ENOG4105QPS Monooxygenase GUY37_RS16150 ENOG4107VFR oxidoreductase GUY37_RS16175 ENOG4105CBP Major Facilitator GUY37_RS16180 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GUY37_RS16185 ENOG4105W1N transcriptional regulator GUY37_RS16235 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase GUY37_RS16245 ENOG4105CEV competence damage-inducible protein GUY37_RS16255 ENOG4105CEP NADH dehydrogenase GUY37_RS16325 ENOG4107SJB teichoic acid biosynthesis GUY37_RS16325 ENOG4107SJB teichoic acid biosynthesis GUY37_RS16330 ENOG4107SJB teichoic acid biosynthesis GUY37_RS16340 ENOG4105EY8 ABC transporter GUY37_RS16350 ENOG4105BZF Glycosyl transferase (Group 1 GUY37_RS16360 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GUY37_RS16370 ENOG4108SHN Glycosyl transferase, family 2 GUY37_RS16405 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GUY37_RS16410 ENOG4107RGD Major Facilitator superfamily GUY37_RS16435 ENOG4107QTZ amino acid GUY37_RS16445 ENOG4105D2S major facilitator superfamily GUY37_RS16455 ENOG4107YCY Transcriptional regulator GUY37_RS16460 ENOG4105CB5 ATP-dependent DNA helicase recG GUY37_RS16470 ENOG4108Z4U Ferredoxin GUY37_RS16475 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GUY37_RS16490 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GUY37_RS16495 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) GUY37_RS16505 ENOG410635A Membrane GUY37_RS16515 ENOG4105CSH Transporter GUY37_RS16530 ENOG4105EY8 ABC transporter GUY37_RS16560 ENOG4105VFE sira family GUY37_RS16570 ENOG4105CSV Glutaminase GUY37_RS16585 ENOG4108Z4U Ferredoxin GUY37_RS16605 ENOG4105VZ8 Transcriptional regulator GUY37_RS16620 ENOG4105CXG d-lactate dehydrogenase GUY37_RS16625 ENOG4105D1H recombination factor protein RarA GUY37_RS16650 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) GUY37_RS16655 ENOG4107RSM transcriptional regulator GUY37_RS16660 ENOG4105DEN Luciferase family GUY37_RS16665 ENOG4105D8V Glucose sorbosone dehydrogenase GUY37_RS16675 ENOG4105VT3 DNA binding domain protein, excisionase family GUY37_RS16690 ENOG4105C9K Endothelin-converting enzyme 1 GUY37_RS16705 ENOG4105DFM M18 family aminopeptidase GUY37_RS16730 ENOG4105C7Z Conserved Protein GUY37_RS16745 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GUY37_RS16760 ENOG4105CSH Transporter GUY37_RS16765 ENOG4105CHR reductase GUY37_RS16770 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GUY37_RS16780 ENOG4105EV8 ectoine hydroxylase GUY37_RS16790 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) GUY37_RS16800 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase GUY37_RS16815 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GUY37_RS16820 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GUY37_RS16825 ENOG4105CSH Transporter GUY37_RS16835 ENOG4105C1G acyl-Coa dehydrogenase GUY37_RS16840 ENOG4105CHR reductase GUY37_RS16845 ENOG4105CEY Amp-dependent synthetase and ligase GUY37_RS16855 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GUY37_RS16860 ENOG4105PMW Domain of unknown function (DUF1990) GUY37_RS16865 ENOG4107RSM transcriptional regulator GUY37_RS16875 ENOG4105C1G acyl-Coa dehydrogenase GUY37_RS16905 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GUY37_RS16925 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) GUY37_RS16930 ENOG4105MT3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) GUY37_RS16945 ENOG4105KI2 Urea amidohydrolase subunit beta GUY37_RS16950 ENOG4108YZ9 Urea amidohydrolase subunit gamma GUY37_RS16960 ENOG4108IPW abc transporter atp-binding protein GUY37_RS16965 ENOG4105CM4 permease protein GUY37_RS16990 ENOG4105CQB FAD linked oxidase domain protein GUY37_RS16995 ENOG4105SHT UspA domain-containing protein GUY37_RS17000 ENOG4105D29 Helix-turn-helix type 11 domain protein GUY37_RS17010 ENOG4107R9S Malate synthase GUY37_RS17030 ENOG4105D5U fad dependent oxidoreductase GUY37_RS17035 ENOG4107QMH DNA methylase GUY37_RS17060 ENOG4107QTZ amino acid GUY37_RS17075 ENOG4107HP6 Transcriptional regulator GUY37_RS17090 ENOG4105BZJ Electron transfer flavoprotein GUY37_RS17095 ENOG4105C10 Electron transfer flavoprotein GUY37_RS17120 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GUY37_RS17150 ENOG4107RPQ ABC transporter GUY37_RS17160 ENOG4105C94 Transporter GUY37_RS17235 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) GUY37_RS17240 ENOG4105C94 Transporter GUY37_RS17260 ENOG4105C84 Histidine ammonia-lyase GUY37_RS17265 ENOG4105CI2 imidazolone-5-propionate hydrolase GUY37_RS17270 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GUY37_RS17275 ENOG4105CGP Urocanate hydratase GUY37_RS17280 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GUY37_RS17285 ENOG4105CSU acyl-Coa dehydrogenase GUY37_RS17290 ENOG4105DND Transcriptional regulator GUY37_RS17295 ENOG4105CSH Transporter GUY37_RS17315 ENOG4107RSM transcriptional regulator GUY37_RS17320 ENOG4105CHU acetyl-coa acetyltransferase GUY37_RS17330 ENOG4105C1G acyl-Coa dehydrogenase GUY37_RS17335 ENOG4105ETS cytosine purines uracil thiamine allantoin GUY37_RS17345 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GUY37_RS17350 ENOG4105CSH Transporter GUY37_RS17355 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GUY37_RS17360 ENOG4105CE7 Amidase, hydantoinase carbamoylase family GUY37_RS17365 ENOG4105CSH Transporter GUY37_RS17395 ENOG4107SYZ Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GUY37_RS17415 ENOG4108QIU Dehydrogenase GUY37_RS17420 ENOG4105MWK D-amino acid dehydrogenase, small subunit GUY37_RS17425 ENOG4105CHM Aminotransferase GUY37_RS17450 ENOG4108Z6Z Transcriptional regulator GUY37_RS17460 ENOG4105CSH Transporter GUY37_RS17465 ENOG4107S4Y M20 DapE family protein YgeY GUY37_RS17490 ENOG4107WTH Galactitol-1-phosphate dehydrogenase GUY37_RS17495 ENOG4105C0D helicase GUY37_RS17535 ENOG4105C5R Aminotransferase GUY37_RS17540 ENOG4105CQB FAD linked oxidase domain protein GUY37_RS17545 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GUY37_RS17555 ENOG4105DRR Transcriptional regulator, GntR family GUY37_RS17560 ENOG4105CFC Transporter GUY37_RS17570 ENOG4108IJ0 Aspartate ammonia-lyase GUY37_RS17635 ENOG4105C1J atp-dependent rna helicase GUY37_RS17645 ENOG4105IYB L-carnitine dehydratase bile acid-inducible protein F GUY37_RS17650 ENOG4108M9J MaoC like domain protein GUY37_RS17655 ENOG4105C1G acyl-Coa dehydrogenase GUY37_RS17660 ENOG4105C1G acyl-Coa dehydrogenase GUY37_RS17685 ENOG4105EUB pirin domain protein GUY37_RS17690 ENOG4105FS7 Transcriptional regulator GUY37_RS17700 ENOG4105ES4 Nitrilase GUY37_RS17720 ENOG4105EW9 transcriptional regulator AsnC family GUY37_RS17725 ENOG4105CH2 amidohydrolase GUY37_RS17730 ENOG4107RCH Diaminopropionate ammonia-lyase GUY37_RS17755 ENOG4105C0D helicase GUY37_RS17780 ENOG4105E3J oxidoreductase GUY37_RS17785 ENOG4105C84 Histidine ammonia-lyase GUY37_RS17790 ENOG4105Q56 cytochrome P450 GUY37_RS17800 ENOG4107QN2 dihydrolipoyl dehydrogenase GUY37_RS17805 ENOG4108IA2 Sodium pantothenate symporter GUY37_RS17840 ENOG4106ZX3 phosphonate ABC transporter, periplasmic phosphonate-binding protein GUY37_RS17845 ENOG4105D5T phosphonate abc transporter GUY37_RS17850 ENOG4105S7S phosphonate abc transporter GUY37_RS17855 ENOG4108KAZ Involved in phosphonate degradation (By similarity) GUY37_RS17865 ENOG4105EQX glucarate dehydratase GUY37_RS17875 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase GUY37_RS17880 ENOG4105DIA mandelate racemase muconate lactonizing GUY37_RS17885 ENOG4105EQX glucarate dehydratase GUY37_RS17900 ENOG4105SHT UspA domain-containing protein GUY37_RS17920 ENOG4106NZI LysR family Transcriptional regulator GUY37_RS17945 ENOG4108UZX fmn reductase GUY37_RS17975 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GUY37_RS17980 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GUY37_RS17990 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GUY37_RS18000 ENOG4105ERH Fumarylacetoacetate hydrolase GUY37_RS18010 ENOG4105CUB amino acid GUY37_RS18030 ENOG4105FDP GntR family transcriptional regulator GUY37_RS18040 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GUY37_RS18045 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GUY37_RS18060 ENOG4105XPP Protein of unknown function (DUF1275) GUY37_RS18065 ENOG4105CSH Transporter GUY37_RS18085 ENOG4108R85 Short chain dehydrogenase GUY37_RS18090 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GUY37_RS18095 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ GUY37_RS18100 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GUY37_RS18105 ENOG4105CHR reductase GUY37_RS18110 ENOG4105CEY Amp-dependent synthetase and ligase GUY37_RS18130 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit GUY37_RS18135 ENOG4105DDW LysR family Transcriptional regulator GUY37_RS18140 ENOG4105E2A Dehydrogenase GUY37_RS18160 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GUY37_RS18180 ENOG4105EMU Dehydrogenase GUY37_RS18205 ENOG4105E39 Enoyl-CoA hydratase GUY37_RS18210 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GUY37_RS18215 ENOG4105E39 Enoyl-CoA hydratase GUY37_RS18220 ENOG4105CHU acetyl-coa acetyltransferase GUY37_RS18225 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GUY37_RS18230 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit GUY37_RS18235 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit GUY37_RS18240 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit GUY37_RS18245 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit GUY37_RS18260 ENOG4108RZE Tetr family transcriptional regulator GUY37_RS18275 ENOG4105CQB FAD linked oxidase domain protein GUY37_RS18280 ENOG4107TE5 Lipid kinase GUY37_RS18285 ENOG4105DXM phenylacetic acid degradation protein GUY37_RS18300 ENOG4105CSH Transporter GUY37_RS18305 ENOG4105C7B Threonine dehydratase GUY37_RS18315 ENOG4105DKW ABC transporter GUY37_RS18325 ENOG4107258 Transcriptional regulator GUY37_RS18350 ENOG4105EJQ L-serine dehydratase GUY37_RS18375 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GUY37_RS18380 ENOG4105DRR Transcriptional regulator, GntR family GUY37_RS18385 ENOG4108K88 Membrane GUY37_RS18390 ENOG4107258 Transcriptional regulator GUY37_RS18405 ENOG4105C94 Transporter GUY37_RS18420 ENOG4105C10 Electron transfer flavoprotein GUY37_RS18425 ENOG4105BZJ Electron transfer flavoprotein GUY37_RS18470 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 GUY37_RS18480 ENOG4105E1V na solute symporter GUY37_RS18490 ENOG4105FDT acyl-CoA dehydrogenase GUY37_RS18505 ENOG4108RZE Tetr family transcriptional regulator GUY37_RS18520 ENOG4105C57 major facilitator superfamily GUY37_RS18530 ENOG4105C26 Dehydrogenase GUY37_RS18535 ENOG4105BZG amino acid carrier protein GUY37_RS18570 ENOG4105CFC Transporter GUY37_RS18575 ENOG4105CE7 Amidase, hydantoinase carbamoylase family GUY37_RS18580 ENOG4105DDW LysR family Transcriptional regulator GUY37_RS18615 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GUY37_RS18620 ENOG4105C2W permease GUY37_RS18650 ENOG4105JAB phenazine biosynthesis protein, phzf family GUY37_RS18655 ENOG4107VUZ GUY37_RS18675 ENOG4105DQ4 alcohol dehydrogenase GUY37_RS18685 ENOG4105CQB FAD linked oxidase domain protein GUY37_RS18755 ENOG4105CJN penicillin-binding protein GUY37_RS18760 ENOG4107TPY serine threonine protein kinase GUY37_RS18785 ENOG4108U4N (sortase) family GUY37_RS18790 ENOG4105ZJT Cell division protein CrgA GUY37_RS18800 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) GUY37_RS18810 ENOG4105DJ2 Major Facilitator Superfamily GUY37_RS18815 ENOG4105C75 arginyL-tRNA synthetase GUY37_RS18820 ENOG4107RE3 peptidase, S41 GUY37_RS18830 ENOG4108IPT Naphthoate synthase GUY37_RS18835 ENOG4105C1G acyl-Coa dehydrogenase GUY37_RS18840 ENOG4105CHR reductase GUY37_RS18845 ENOG4105CEY Amp-dependent synthetase and ligase GUY37_RS18875 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) GUY37_RS18885 ENOG4105C26 Dehydrogenase GUY37_RS18930 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GUY37_RS18935 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GUY37_RS18940 ENOG4105K7N UPF0232 protein GUY37_RS18945 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GUY37_RS18950 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)