locus-tag	class	description
E4341_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4341_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4341_RS00035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4341_RS00035	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E4341_RS00045	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4341_RS00050	COG0318	PFAM AMP-dependent synthetase and ligase
E4341_RS00070	COG0175	sulfate reduction
E4341_RS00075	COG0529	Catalyzes the synthesis of activated sulfate
E4341_RS00075	COG2895	sulfate adenylyltransferase (ATP) activity
E4341_RS00080	COG3264	Mechanosensitive ion channel
E4341_RS00080	COG1196	nuclear chromosome segregation
E4341_RS00105	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E4341_RS00120	COG1218	3'(2'),5'-bisphosphate nucleotidase
E4341_RS00130	COG0745	RESPONSE REGULATOR receiver
E4341_RS00145	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4341_RS00150	COG1684	flagellar biosynthetic protein fliR
E4341_RS00155	COG1987	bacterial-type flagellum assembly
E4341_RS00160	COG0302	gtp cyclohydrolase
E4341_RS00170	COG0477	Major facilitator Superfamily
E4341_RS00175	COG0784	Response regulator, receiver
E4341_RS00175	COG2205	protein histidine kinase activity
E4341_RS00180	COG2197	response regulator
E4341_RS00190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4341_RS00210	COG1476	TRANSCRIPTIONal
E4341_RS00220	COG1322	Protein conserved in bacteria
E4341_RS00230	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4341_RS00235	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E4341_RS00240	COG0778	Nitroreductase
E4341_RS00245	COG3474	cytochrome
E4341_RS00250	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E4341_RS00255	COG2816	NAD+ diphosphatase activity
E4341_RS00305	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E4341_RS00310	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4341_RS00325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4341_RS00345	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4341_RS00385	COG2917	probably involved in intracellular septation
E4341_RS00390	COG0552	protein localization to endoplasmic reticulum
E4341_RS00400	COG0024	Methionine aminopeptidase
E4341_RS00410	COG2824	Alkylphosphonate utilization operon protein PhnA
E4341_RS00415	COG0523	cobalamin synthesis protein
E4341_RS00420	COG1899	peptidyl-lysine modification to peptidyl-hypusine
E4341_RS00435	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4341_RS00445	COG3639	organic phosphonate transmembrane transporter activity
E4341_RS00450	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E4341_RS00455	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4341_RS00460	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4341_RS00465	COG3135	benzoate transporter
E4341_RS00475	COG0625	glutathione transferase activity
E4341_RS00480	COG3422	double-strand break repair
E4341_RS00485	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4341_RS00495	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4341_RS00500	COG1748	Saccharopine dehydrogenase
E4341_RS00510	COG0793	Belongs to the peptidase S41A family
E4341_RS00520	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E4341_RS00525	COG0799	negative regulation of ribosome biogenesis
E4341_RS00530	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E4341_RS00540	COG0735	belongs to the Fur family
E4341_RS00555	COG2130	NADP-dependent
E4341_RS00560	COG0784	Response regulator, receiver
E4341_RS00600	COG0433	COG0433 Predicted ATPase
E4341_RS00605	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E4341_RS00615	COG0456	acetyltransferase
E4341_RS00625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4341_RS00630	COG1702	phosphate starvation-inducible protein PhoH
E4341_RS00640	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4341_RS00645	COG1396	sequence-specific DNA binding
E4341_RS00650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4341_RS00665	COG2205	protein histidine kinase activity
E4341_RS00675	COG2095	MarC family integral membrane protein
E4341_RS00695	COG0501	Belongs to the peptidase M48B family
E4341_RS00710	COG1272	protein, Hemolysin III
E4341_RS00730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4341_RS00740	COG0463	Glycosyl transferase, family 2
E4341_RS00745	COG0459	protein refolding
E4341_RS00760	COG0166	Belongs to the GPI family
E4341_RS00770	COG0514	ATP-dependent DNA helicase (RecQ)
E4341_RS00790	COG2814	Major facilitator Superfamily
E4341_RS00795	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4341_RS00820	COG4232	protein-disulfide reductase activity
E4341_RS00825	COG0596	Alpha beta hydrolase
E4341_RS00830	COG1024	Enoyl-CoA hydratase
E4341_RS00840	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E4341_RS00845	COG1297	OPT oligopeptide transporter protein
E4341_RS00880	COG1937	Protein conserved in bacteria
E4341_RS00940	COG0527	aspartate kinase activity
E4341_RS00945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4341_RS00955	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E4341_RS00975	COG0730	response to heat
E4341_RS00980	COG1959	2 iron, 2 sulfur cluster binding
E4341_RS00990	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4341_RS01015	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4341_RS01020	COG0045	succinate-CoA ligase (ADP-forming) activity
E4341_RS01025	COG2814	Major facilitator Superfamily
E4341_RS01030	COG4771	TonB-dependent receptor
E4341_RS01070	COG1196	nuclear chromosome segregation
E4341_RS01070	COG0741	lytic transglycosylase activity
E4341_RS01070	COG0739	heme binding
E4341_RS01105	COG2197	response regulator
E4341_RS01115	COG5001	Diguanylate cyclase
E4341_RS01115	COG4251	negative regulation of phosphorylation
E4341_RS01115	COG2203	Gaf domain
E4341_RS01115	COG3706	GGDEF domain
E4341_RS01135	COG0405	Gamma-glutamyltransferase
E4341_RS01145	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4341_RS01145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4341_RS01150	COG0671	phosphoesterase, PA-phosphatase related
E4341_RS01155	COG0427	acetyl-CoA hydrolase
E4341_RS01165	COG0137	argininosuccinate synthase activity
E4341_RS01170	COG0612	Peptidase, M16
E4341_RS01180	COG0706	membrane insertase activity
E4341_RS01190	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E4341_RS01195	COG0398	Pfam SNARE associated Golgi protein
E4341_RS01200	COG0642	Histidine kinase
E4341_RS01205	COG1064	alcohol dehydrogenase
E4341_RS01230	COG0784	Response regulator, receiver
E4341_RS01230	COG2205	protein histidine kinase activity
E4341_RS01230	COG2198	Histidine kinase
E4341_RS01285	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4341_RS01295	COG0189	ligase activity
E4341_RS01300	COG0606	chelatase, subunit chli
E4341_RS01310	COG2211	Major facilitator Superfamily
E4341_RS01330	COG0336	Belongs to the RNA methyltransferase TrmD family
E4341_RS01335	COG0335	large ribosomal subunit rRNA binding
E4341_RS01345	COG3483	tryptophan 2,3-dioxygenase activity
E4341_RS01355	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E4341_RS01370	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4341_RS01385	COG0779	Required for maturation of 30S ribosomal subunits
E4341_RS01390	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4341_RS01395	COG1228	amidohydrolase
E4341_RS01405	COG1671	Belongs to the UPF0178 family
E4341_RS01470	COG0454	-acetyltransferase
E4341_RS01535	COG1872	DUF167
E4341_RS01545	COG2086	electron transfer activity
E4341_RS01575	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4341_RS01575	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4341_RS01585	COG0346	lactoylglutathione lyase activity
E4341_RS01600	COG1131	(ABC) transporter
E4341_RS01605	COG0596	Alpha beta hydrolase
E4341_RS01610	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4341_RS01625	COG0673	inositol 2-dehydrogenase activity
E4341_RS01640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4341_RS01645	COG2364	Membrane
E4341_RS01650	COG0745	RESPONSE REGULATOR receiver
E4341_RS01655	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4341_RS01660	COG0352	thiamine-phosphate diphosphorylase activity
E4341_RS01675	COG0495	leucyl-tRNA aminoacylation
E4341_RS01725	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4341_RS01740	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E4341_RS01745	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E4341_RS01750	COG0424	maF-like protein
E4341_RS01755	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4341_RS01760	COG0237	dephospho-CoA kinase activity
E4341_RS01765	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4341_RS01770	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E4341_RS01775	COG0484	heat shock protein binding
E4341_RS01780	COG0443	Heat shock 70 kDa protein
E4341_RS01805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4341_RS01815	COG0180	Tryptophanyl-tRNA synthetase
E4341_RS01820	COG0728	peptidoglycan biosynthetic process
E4341_RS01850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4341_RS01855	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4341_RS01860	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4341_RS01865	COG2226	methyltransferase
E4341_RS01875	COG0494	nUDIX hydrolase
E4341_RS01880	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E4341_RS01895	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4341_RS01905	COG2902	Dehydrogenase
E4341_RS01915	COG1846	Transcriptional regulator
E4341_RS01920	COG1764	response to oxidative stress
E4341_RS01925	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E4341_RS01935	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E4341_RS01940	COG0697	spore germination
E4341_RS01945	COG0756	dUTP diphosphatase activity
E4341_RS01950	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E4341_RS01975	COG0633	Ferredoxin
E4341_RS02005	COG1741	Belongs to the pirin family
E4341_RS02010	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4341_RS02025	COG0538	isocitrate dehydrogenase activity
E4341_RS02065	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4341_RS02085	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4341_RS02095	COG1674	ftsk spoiiie
E4341_RS02100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4341_RS02115	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4341_RS02120	COG0281	malic enzyme
E4341_RS02120	COG0280	phosphate acetyltransferase
E4341_RS02130	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4341_RS02135	COG1505	serine-type exopeptidase activity
E4341_RS02140	COG1505	serine-type exopeptidase activity
E4341_RS02155	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4341_RS02170	COG2885	chlorophyll binding
E4341_RS02170	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E4341_RS02175	COG2885	chlorophyll binding
E4341_RS02195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4341_RS02205	COG1741	Belongs to the pirin family
E4341_RS02210	COG1522	sequence-specific DNA binding
E4341_RS02240	COG0300	oxidoreductase activity
E4341_RS02245	COG1959	2 iron, 2 sulfur cluster binding
E4341_RS02255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4341_RS02255	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4341_RS02270	COG0138	bifunctional purine biosynthesis protein purh
E4341_RS02275	COG0412	Dienelactone hydrolase
E4341_RS02285	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4341_RS02290	COG1420	regulation of RNA biosynthetic process
E4341_RS02305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4341_RS02310	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4341_RS02320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4341_RS02330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4341_RS02340	COG2942	2-epimerase
E4341_RS02350	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4341_RS02350	COG0506	proline dehydrogenase activity
E4341_RS02350	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4341_RS02370	COG0438	transferase activity, transferring glycosyl groups
E4341_RS02405	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4341_RS02420	COG0318	PFAM AMP-dependent synthetase and ligase
E4341_RS02450	COG2171	N-acyltransferase activity
E4341_RS02465	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4341_RS02470	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4341_RS02480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4341_RS02490	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4341_RS02525	COG0670	Belongs to the BI1 family
E4341_RS02535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4341_RS02545	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E4341_RS02560	COG0640	Transcriptional regulator
E4341_RS02580	COG2205	protein histidine kinase activity
E4341_RS02580	COG0784	Response regulator, receiver
E4341_RS02620	COG3046	protein related to deoxyribodipyrimidine photolyase
E4341_RS02645	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4341_RS02650	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4341_RS02655	COG4133	protoheme IX ABC transporter activity
E4341_RS02660	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E4341_RS02665	COG1012	belongs to the aldehyde dehydrogenase family
E4341_RS02680	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E4341_RS02690	COG1253	flavin adenine dinucleotide binding
E4341_RS02705	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E4341_RS02710	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E4341_RS02715	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E4341_RS02725	COG0477	Major facilitator Superfamily
E4341_RS02730	COG2962	Rard protein
E4341_RS02735	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4341_RS02740	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E4341_RS02765	COG0656	L-ascorbic acid biosynthetic process
E4341_RS02770	COG2267	carboxylic ester hydrolase activity
E4341_RS02775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4341_RS02820	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4341_RS02820	COG1024	Enoyl-CoA hydratase
E4341_RS02825	COG0183	Belongs to the thiolase family
E4341_RS02865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4341_RS02870	COG0165	Argininosuccinate lyase
E4341_RS02880	COG0019	diaminopimelate decarboxylase activity
E4341_RS02895	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4341_RS02900	COG0339	signal peptide processing
E4341_RS02905	COG0598	Magnesium transport protein CorA
E4341_RS02910	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E4341_RS02915	COG2861	carbohydrate metabolic process
E4341_RS02960	COG2261	transglycosylase associated protein
E4341_RS02970	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
E4341_RS02975	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4341_RS02980	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4341_RS02990	COG3655	Transcriptional regulator
E4341_RS03000	COG1309	transcriptional regulator
E4341_RS03015	COG0124	histidyl-tRNA synthetase
E4341_RS03030	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4341_RS03040	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4341_RS03085	COG0101	tRNA pseudouridine synthase activity
E4341_RS03100	COG0242	peptide deformylase activity
E4341_RS03140	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E4341_RS03155	COG2311	Membrane
E4341_RS03165	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4341_RS03180	COG2351	hydroxyisourate hydrolase activity
E4341_RS03185	COG3040	lipid binding
E4341_RS03195	COG1028	Short-chain dehydrogenase reductase Sdr
E4341_RS03210	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E4341_RS03220	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4341_RS03235	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E4341_RS03240	COG2081	HI0933 family
E4341_RS03255	COG0745	RESPONSE REGULATOR receiver
E4341_RS03260	COG2205	protein histidine kinase activity
E4341_RS03265	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E4341_RS03270	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4341_RS03270	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4341_RS03275	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4341_RS03280	COG2205	protein histidine kinase activity
E4341_RS03285	COG0745	RESPONSE REGULATOR receiver
E4341_RS03305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4341_RS03310	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4341_RS03315	COG4206	TonB-dependent receptor
E4341_RS03345	COG5487	UPF0391 membrane protein
E4341_RS03400	COG4964	Belongs to the GSP D family
E4341_RS03440	COG1473	amidohydrolase
E4341_RS03450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4341_RS03480	COG0842	Transport permease protein
E4341_RS03495	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4341_RS03500	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4341_RS03525	COG0730	response to heat
E4341_RS03535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4341_RS03545	COG2860	membrane
E4341_RS03565	COG1201	RNA secondary structure unwinding
E4341_RS03570	COG1199	ATP-dependent helicase activity
E4341_RS03575	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4341_RS03590	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4341_RS03600	COG0204	Acyl-transferase
E4341_RS03615	COG2884	Cell division ATP-binding protein ftsE
E4341_RS03630	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4341_RS03635	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4341_RS03655	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4341_RS03660	COG0545	Peptidyl-prolyl cis-trans isomerase
E4341_RS03665	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E4341_RS03695	COG2813	Specifically methylates the guanine in position
E4341_RS03700	COG1187	pseudouridine synthase activity
E4341_RS03705	COG0135	phosphoribosylanthranilate isomerase activity
E4341_RS03710	COG0133	tryptophan synthase activity
E4341_RS03720	COG0159	tryptophan synthase activity
E4341_RS03735	COG0285	dihydrofolate synthase activity
E4341_RS03760	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4341_RS03765	COG3178	'Phosphotransferase
E4341_RS03770	COG0802	atpase or kinase
E4341_RS03780	COG1506	peptidase
E4341_RS03780	COG0823	Involved in the tonB-independent uptake of proteins
E4341_RS03785	COG1506	peptidase
E4341_RS03785	COG0823	Involved in the tonB-independent uptake of proteins
E4341_RS03795	COG2982	Protein involved in outer membrane biogenesis
E4341_RS03830	COG1446	asparaginase
E4341_RS03855	COG3932	Exopolysaccharide synthesis, ExoD
E4341_RS03870	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
E4341_RS03875	COG0183	Belongs to the thiolase family
E4341_RS03880	COG1028	Short-chain dehydrogenase reductase Sdr
E4341_RS03885	COG2885	chlorophyll binding
E4341_RS03885	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E4341_RS03900	COG2957	Belongs to the agmatine deiminase family
E4341_RS03905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4341_RS03915	COG0859	PFAM glycosyl transferase family 9
E4341_RS03920	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E4341_RS03930	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4341_RS03935	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4341_RS03940	COG5002	protein histidine kinase activity
E4341_RS03940	COG0784	Response regulator, receiver
E4341_RS03965	COG0072	phenylalanine-tRNA ligase activity
E4341_RS03965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4341_RS03995	COG0784	Response regulator, receiver
E4341_RS04040	COG1280	lysine exporter protein (LysE YggA)
E4341_RS04045	COG0542	response to heat
E4341_RS04060	COG2852	Protein conserved in bacteria
E4341_RS04065	COG2890	protein-(glutamine-N5) methyltransferase activity
E4341_RS04070	COG1295	ribonuclease BN
E4341_RS04075	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4341_RS04085	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E4341_RS04150	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4341_RS04165	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E4341_RS04170	COG0539	negative regulation of cytoplasmic translation
E4341_RS04190	COG3104	oligopeptide transport
E4341_RS04210	COG0312	modulator of DNA gyrase
E4341_RS04220	COG0842	Transport permease protein
E4341_RS04225	COG1131	(ABC) transporter
E4341_RS04240	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E4341_RS04245	COG1138	Cytochrome C-type biogenesis protein
E4341_RS04270	COG2205	protein histidine kinase activity
E4341_RS04275	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E4341_RS04320	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E4341_RS04335	COG0837	glucose binding
E4341_RS04345	COG0363	glucosamine-6-phosphate deaminase activity
E4341_RS04350	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E4341_RS04360	COG0107	imidazoleglycerol-phosphate synthase activity
E4341_RS04365	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E4341_RS04370	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E4341_RS04400	COG2308	Evidence 4 Homologs of previously reported genes of
E4341_RS04420	COG4774	siderophore transport
E4341_RS04425	COG3128	pkhd-type hydroxylase
E4341_RS04445	COG1477	protein flavinylation
E4341_RS04450	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E4341_RS04455	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4341_RS04460	COG1619	proteins homologs of microcin C7 resistance protein MccF
E4341_RS04465	COG0358	DNA primase activity
E4341_RS04470	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4341_RS04490	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
E4341_RS04495	COG5507	3-demethylubiquinone-9 3-methyltransferase
E4341_RS04515	COG1733	regulation of RNA biosynthetic process
E4341_RS04525	COG0513	Belongs to the DEAD box helicase family
E4341_RS04540	COG3584	3D domain protein
E4341_RS04540	COG1388	LysM domain
E4341_RS04550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4341_RS04560	COG0754	glutathionylspermidine amidase activity
E4341_RS04570	COG3789	protein conserved in bacteria
E4341_RS04595	COG0183	Belongs to the thiolase family
E4341_RS04605	COG2205	protein histidine kinase activity
E4341_RS04605	COG2202	Pas domain
E4341_RS04615	COG0516	GMP reductase activity
E4341_RS04615	COG0517	IMP dehydrogenase activity
E4341_RS04620	COG2304	oxidoreductase activity
E4341_RS04625	COG0475	glutathione-regulated potassium exporter activity
E4341_RS04625	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4341_RS04645	COG1742	UPF0060 membrane protein
E4341_RS04650	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4341_RS04655	COG4771	TonB-dependent receptor
E4341_RS04680	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
E4341_RS04685	COG1733	regulation of RNA biosynthetic process
E4341_RS04705	COG2205	protein histidine kinase activity
E4341_RS04710	COG2166	iron-sulfur cluster assembly
E4341_RS04740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4341_RS04745	COG2205	protein histidine kinase activity
E4341_RS04750	COG0745	RESPONSE REGULATOR receiver
E4341_RS04765	COG3693	PFAM glycoside hydrolase, family 10
E4341_RS04765	COG3507	Belongs to the glycosyl hydrolase 43 family
E4341_RS04765	COG2382	esterase
E4341_RS04785	COG5006	permease, DMT superfamily
E4341_RS04795	COG3920	Histidine kinase
E4341_RS04820	COG2885	chlorophyll binding
E4341_RS04835	COG4957	zinc ion binding
E4341_RS04875	COG2076	Multidrug Resistance protein
E4341_RS04880	COG2983	Belongs to the UPF0260 family
E4341_RS04905	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E4341_RS04915	COG4695	Portal protein
E4341_RS04960	COG0484	heat shock protein binding
E4341_RS04970	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E4341_RS04985	COG0564	pseudouridine synthase activity
E4341_RS05015	COG0129	dihydroxy-acid dehydratase activity
E4341_RS05020	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E4341_RS05035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4341_RS05040	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E4341_RS05045	COG0066	3-isopropylmalate dehydratase activity
E4341_RS05055	COG0004	ammonium transporteR
E4341_RS05070	COG2819	hydrolase of the alpha beta superfamily
E4341_RS05075	COG2190	(PTS) system
E4341_RS05075	COG2211	Major facilitator Superfamily
E4341_RS05080	COG1082	Xylose isomerase domain protein TIM barrel
E4341_RS05085	COG1609	Transcriptional regulator
E4341_RS05090	COG0366	Alpha amylase catalytic
E4341_RS05130	COG0753	catalase activity
E4341_RS05135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4341_RS05140	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4341_RS05150	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4341_RS05160	COG0849	cell division
E4341_RS05165	COG4771	TonB-dependent receptor
E4341_RS05175	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E4341_RS05190	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4341_RS05215	COG2205	protein histidine kinase activity
E4341_RS05220	COG0745	RESPONSE REGULATOR receiver
E4341_RS05225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4341_RS05230	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4341_RS05250	COG1573	uracil-dna glycosylase
E4341_RS05260	COG1766	The M ring may be actively involved in energy transduction
E4341_RS05265	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4341_RS05270	COG1317	bacterial-type flagellum organization
E4341_RS05275	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4341_RS05280	COG2204	response regulator
E4341_RS05290	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4341_RS05295	COG5002	protein histidine kinase activity
E4341_RS05300	COG0784	Response regulator, receiver
E4341_RS05305	COG0745	RESPONSE REGULATOR receiver
E4341_RS05310	COG1051	belongs to the nudix hydrolase family
E4341_RS05315	COG3237	CsbD-like
E4341_RS05345	COG1722	exodeoxyribonuclease VII activity
E4341_RS05350	COG0142	geranyltranstransferase activity
E4341_RS05355	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4341_RS05365	COG0583	DNA-binding transcription factor activity
E4341_RS05370	COG1648	precorrin-2 dehydrogenase activity
E4341_RS05370	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4341_RS05380	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4341_RS05385	COG0175	sulfate reduction
E4341_RS05410	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E4341_RS05415	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
E4341_RS05420	COG4786	Flagellar basal body rod
E4341_RS05425	COG4786	Flagellar basal body rod
E4341_RS05470	COG0490	domain, Protein
E4341_RS05470	COG0471	metal ion transport
E4341_RS05490	COG4221	oxidoreductase activity
E4341_RS05500	COG0318	PFAM AMP-dependent synthetase and ligase
E4341_RS05520	COG4771	TonB-dependent receptor
E4341_RS05540	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4341_RS05545	COG2818	Glycosylase
E4341_RS05555	COG0354	folic acid binding
E4341_RS05580	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4341_RS05615	COG0316	Belongs to the HesB IscA family
E4341_RS05635	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E4341_RS05640	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4341_RS05645	COG0784	Response regulator, receiver
E4341_RS05645	COG2198	Histidine kinase
E4341_RS05645	COG2205	protein histidine kinase activity
E4341_RS05650	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4341_RS05660	COG0356	it plays a direct role in the translocation of protons across the membrane
E4341_RS05665	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E4341_RS05670	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E4341_RS05675	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E4341_RS05695	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4341_RS05705	COG0509	glycine decarboxylation via glycine cleavage system
E4341_RS05710	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4341_RS05720	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E4341_RS05725	COG1335	isochorismatase
E4341_RS05730	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4341_RS05745	COG0018	arginyl-trna synthetase
E4341_RS05765	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4341_RS05785	COG0151	Belongs to the GarS family
E4341_RS05805	COG1519	Transferase
E4341_RS05810	COG2121	Domain of unknown function (DUF374)
E4341_RS05815	COG1132	(ABC) transporter
E4341_RS05840	COG0483	inositol monophosphate 1-phosphatase activity
E4341_RS05845	COG0312	modulator of DNA gyrase
E4341_RS05865	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E4341_RS05875	COG0656	L-ascorbic acid biosynthetic process
E4341_RS05885	COG0405	Gamma-glutamyltransferase
E4341_RS05890	COG0848	biopolymer transport protein
E4341_RS05895	COG0302	gtp cyclohydrolase
E4341_RS05900	COG0215	cysteine-tRNA ligase activity
E4341_RS05910	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4341_RS05930	COG2204	response regulator
E4341_RS06005	COG0012	GTP binding
E4341_RS06010	COG2847	Copper chaperone PCu(A)C
E4341_RS06030	COG0193	aminoacyl-tRNA hydrolase activity
E4341_RS06040	COG2205	protein histidine kinase activity
E4341_RS06040	COG0784	Response regulator, receiver
E4341_RS06050	COG0573	inorganic phosphate transmembrane transporter activity
E4341_RS06060	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E4341_RS06070	COG0745	RESPONSE REGULATOR receiver
E4341_RS06085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4341_RS06095	COG5001	Diguanylate cyclase
E4341_RS06095	COG3447	MASE1 domain protein
E4341_RS06095	COG5002	protein histidine kinase activity
E4341_RS06100	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4341_RS06105	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E4341_RS06120	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4341_RS06130	COG4152	abc transporter atp-binding protein
E4341_RS06140	COG0739	heme binding
E4341_RS06175	COG0604	alcohol dehydrogenase
E4341_RS06175	COG1028	Short-chain dehydrogenase reductase Sdr
E4341_RS06175	COG3321	synthase
E4341_RS06200	COG1132	(ABC) transporter
E4341_RS06210	COG0483	inositol monophosphate 1-phosphatase activity
E4341_RS06215	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4341_RS06225	COG2193	ferroxidase activity
E4341_RS06235	COG0352	thiamine-phosphate diphosphorylase activity
E4341_RS06260	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4341_RS06270	COG0259	pyridoxamine-phosphate oxidase activity
E4341_RS06275	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4341_RS06280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4341_RS06285	COG1522	sequence-specific DNA binding
E4341_RS06295	COG0251	oxidation-reduction process
E4341_RS06300	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E4341_RS06345	COG0784	Response regulator, receiver
E4341_RS06345	COG2205	protein histidine kinase activity
E4341_RS06355	COG0602	queuosine metabolic process
E4341_RS06380	COG2378	regulation of single-species biofilm formation
E4341_RS06390	COG0745	RESPONSE REGULATOR receiver
E4341_RS06400	COG0482	sulfurtransferase activity
E4341_RS06410	COG1749	Flagellar hook protein flgE
E4341_RS06440	COG1573	uracil-dna glycosylase
E4341_RS06445	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4341_RS06485	COG0488	(ABC) transporter
E4341_RS06490	COG2199	diguanylate cyclase activity
E4341_RS06490	COG2200	EAL domain
E4341_RS06500	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4341_RS06505	COG1706	bacterial-type flagellum-dependent cell motility
E4341_RS06520	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4341_RS06530	COG1611	Belongs to the LOG family
E4341_RS06540	COG1320	monovalent cation:proton antiporter activity
E4341_RS06545	COG2212	antiporter activity
E4341_RS06550	COG1863	multisubunit Na H antiporter MnhE subunit
E4341_RS06555	COG0651	ATP synthesis coupled electron transport
E4341_RS06560	COG1006	Multisubunit Na H antiporter MnhC subunit
E4341_RS06565	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E4341_RS06565	COG2111	Na H antiporter
E4341_RS06585	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E4341_RS06600	COG0525	valine-tRNA ligase activity
E4341_RS06605	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
E4341_RS06615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4341_RS06630	COG1686	Belongs to the peptidase S11 family
E4341_RS06645	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E4341_RS06675	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E4341_RS06680	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4341_RS06695	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4341_RS06715	COG0557	exoribonuclease II activity
E4341_RS06725	COG0626	cystathionine gamma-synthase activity
E4341_RS06740	COG1278	Cold shock
E4341_RS06755	COG2852	Protein conserved in bacteria
E4341_RS06760	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E4341_RS06765	COG2200	EAL domain
E4341_RS06770	COG3739	integral membrane protein
E4341_RS06775	COG0586	Pfam SNARE associated Golgi protein
E4341_RS06785	COG0494	nUDIX hydrolase
E4341_RS06795	COG4774	siderophore transport
E4341_RS06830	COG3590	peptidase
E4341_RS06835	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4341_RS06845	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E4341_RS06850	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E4341_RS06855	COG0248	Ppx GppA phosphatase
E4341_RS06860	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E4341_RS06875	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4341_RS06880	COG1253	flavin adenine dinucleotide binding
E4341_RS06890	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4341_RS06895	COG0250	Participates in transcription elongation, termination and antitermination
E4341_RS06900	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4341_RS06905	COG0081	regulation of translation
E4341_RS06920	COG1733	regulation of RNA biosynthetic process
E4341_RS06940	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4341_RS06945	COG0222	ribosome binding
E4341_RS06975	COG0545	Peptidyl-prolyl cis-trans isomerase
E4341_RS06980	COG0085	RNA polymerase activity
E4341_RS06985	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E4341_RS07005	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E4341_RS07010	COG0049	tRNA binding
E4341_RS07015	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4341_RS07020	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4341_RS07035	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4341_RS07055	COG0681	Belongs to the peptidase S26 family
E4341_RS07060	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E4341_RS07065	COG0439	Biotin carboxylase
E4341_RS07070	COG0511	ligase activity, forming carbon-carbon bonds
E4341_RS07085	COG2022	thiamine diphosphate biosynthetic process
E4341_RS07100	COG0318	PFAM AMP-dependent synthetase and ligase
E4341_RS07140	COG1410	methionine synthase
E4341_RS07140	COG0646	methionine synthase
E4341_RS07150	COG2226	methyltransferase
E4341_RS07160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4341_RS07170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4341_RS07180	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4341_RS07200	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E4341_RS07220	COG1187	pseudouridine synthase activity
E4341_RS07235	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
E4341_RS07240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4341_RS07265	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4341_RS07275	COG0235	Class ii aldolase
E4341_RS07285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4341_RS07290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4341_RS07295	COG3474	cytochrome
E4341_RS07305	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E4341_RS07305	COG1918	ferrous iron import across plasma membrane
E4341_RS07325	COG1904	glucuronate isomerase
E4341_RS07330	COG0246	Mannitol dehydrogenase
E4341_RS07335	COG2721	sulfolactate sulfo-lyase activity
E4341_RS07360	COG3618	amidohydrolase
E4341_RS07365	COG1028	Short-chain dehydrogenase reductase Sdr
E4341_RS07370	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4341_RS07375	COG4948	Mandelate Racemase Muconate Lactonizing
E4341_RS07380	COG1414	Transcriptional regulator
E4341_RS07405	COG1028	Short-chain dehydrogenase reductase Sdr
E4341_RS07410	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
E4341_RS07420	COG1609	Transcriptional regulator
E4341_RS07430	COG2271	Major facilitator Superfamily
E4341_RS07440	COG2272	Belongs to the type-B carboxylesterase lipase family
E4341_RS07460	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
E4341_RS07470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4341_RS07490	COG5442	Flagellar protein FlaF
E4341_RS07495	COG3932	Exopolysaccharide synthesis, ExoD
E4341_RS07505	COG1960	acyl-CoA dehydrogenase activity
E4341_RS07515	COG2239	Acts as a magnesium transporter
E4341_RS07530	COG0321	lipoyl(octanoyl) transferase activity
E4341_RS07570	COG5328	Belongs to the UPF0262 family
E4341_RS07575	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4341_RS07580	COG0424	maF-like protein
E4341_RS07590	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E4341_RS07605	COG0848	biopolymer transport protein
E4341_RS07620	COG0667	Aldo Keto reductase
E4341_RS07630	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4341_RS07635	COG2234	aminopeptidase activity
E4341_RS07645	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E4341_RS07660	COG0546	phosphoglycolate phosphatase activity
E4341_RS07675	COG1940	carbohydrate kinase activity
E4341_RS07685	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
E4341_RS07700	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E4341_RS07720	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4341_RS07735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4341_RS07740	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4341_RS07745	COG1561	YicC-like family, N-terminal region
E4341_RS07750	COG0194	GDP metabolic process
E4341_RS07755	COG0784	Response regulator, receiver
E4341_RS07755	COG2205	protein histidine kinase activity
E4341_RS07765	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4341_RS07770	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E4341_RS07795	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4341_RS07820	COG1741	Belongs to the pirin family
E4341_RS07825	COG2259	Doxx family
E4341_RS07880	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4341_RS07890	COG1971	Probably functions as a manganese efflux pump
E4341_RS07895	COG2986	histidine ammonia-lyase
E4341_RS07900	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4341_RS07920	COG1228	amidohydrolase
E4341_RS07925	COG0784	Response regulator, receiver
E4341_RS07930	COG3920	Histidine kinase
E4341_RS08020	COG2205	protein histidine kinase activity
E4341_RS08020	COG2198	Histidine kinase
E4341_RS08020	COG0784	Response regulator, receiver
E4341_RS08025	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E4341_RS08035	COG5002	protein histidine kinase activity
E4341_RS08060	COG4191	Histidine kinase
E4341_RS08065	COG4566	intracellular signal transduction
E4341_RS08105	COG4771	TonB-dependent receptor
E4341_RS08165	COG2165	general secretion pathway protein
E4341_RS08180	COG4795	General secretion pathway protein
E4341_RS08240	COG0583	DNA-binding transcription factor activity
E4341_RS08260	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4341_RS08265	COG0039	L-malate dehydrogenase activity
E4341_RS08275	COG1525	nuclease
E4341_RS08285	COG1396	sequence-specific DNA binding
E4341_RS08295	COG0668	transmembrane transport
E4341_RS08300	COG0668	transmembrane transport
E4341_RS08355	COG4974	Belongs to the 'phage' integrase family
E4341_RS08370	COG0582	viral genome integration into host DNA
E4341_RS08380	COG0531	amino acid
E4341_RS08405	COG0154	amidase activity
E4341_RS08425	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
E4341_RS08445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4341_RS08475	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4341_RS08510	COG0297	glycogen (starch) synthase activity
E4341_RS08525	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E4341_RS08540	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4341_RS08545	COG0649	NAD binding
E4341_RS08575	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E4341_RS08585	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4341_RS08610	COG1007	ATP synthesis coupled electron transport
E4341_RS08620	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E4341_RS08645	COG0442	prolyl-tRNA aminoacylation
E4341_RS08655	COG1136	(ABC) transporter
E4341_RS08660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4341_RS08675	COG0052	Belongs to the universal ribosomal protein uS2 family
E4341_RS08685	COG0528	UMP kinase activity
E4341_RS08690	COG0233	cytoplasmic translational termination
E4341_RS08695	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4341_RS08710	COG0750	zinc metalloprotease
E4341_RS08715	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4341_RS08725	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4341_RS08740	COG3494	Protein of unknown function (DUF1009)
E4341_RS08745	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4341_RS08755	COG0372	Belongs to the citrate synthase family
E4341_RS08760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4341_RS08765	COG0658	competence protein
E4341_RS08765	COG2333	competence protein COMEC
E4341_RS08770	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4341_RS08775	COG0134	indole-3-glycerol-phosphate synthase activity
E4341_RS08795	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4341_RS08805	COG0149	triose-phosphate isomerase activity
E4341_RS08815	COG0504	CTP synthase activity
E4341_RS08845	COG1960	acyl-CoA dehydrogenase activity
E4341_RS08855	COG0009	L-threonylcarbamoyladenylate synthase
E4341_RS08865	COG1028	Short-chain dehydrogenase reductase Sdr
E4341_RS08875	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E4341_RS08880	COG1360	Flagellar Motor Protein
E4341_RS08885	COG2084	Dehydrogenase
E4341_RS08895	COG0113	porphobilinogen synthase activity
E4341_RS08905	COG0156	8-amino-7-oxononanoate synthase activity
E4341_RS08920	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4341_RS08925	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4341_RS08930	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4341_RS08930	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4341_RS08945	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E4341_RS08955	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E4341_RS08965	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E4341_RS08985	COG0416	fatty acid biosynthetic process
E4341_RS08990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4341_RS08995	COG0776	regulation of translation
E4341_RS09020	COG1612	heme a metabolic process
E4341_RS09030	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4341_RS09035	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E4341_RS09045	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4341_RS09055	COG3243	poly(R)-hydroxyalkanoic acid synthase
E4341_RS09065	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4341_RS09065	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E4341_RS09075	COG1278	Cold shock
E4341_RS09115	COG1595	DNA-templated transcription, initiation
E4341_RS09140	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4341_RS09140	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4341_RS09145	COG0347	Belongs to the P(II) protein family
E4341_RS09150	COG0174	glutamine synthetase
E4341_RS09155	COG0805	protein transport
E4341_RS09160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4341_RS09165	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4341_RS09170	COG0328	RNA-DNA hybrid ribonuclease activity
E4341_RS09175	COG2814	Major facilitator Superfamily
E4341_RS09185	COG0330	HflC and HflK could
E4341_RS09200	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E4341_RS09200	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E4341_RS09210	COG0415	Belongs to the DNA photolyase family
E4341_RS09215	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4341_RS09220	COG2897	thiosulfate sulfurtransferase activity
E4341_RS09225	COG1301	dicarboxylic acid transport
E4341_RS09230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4341_RS09245	COG0187	DNA topoisomerase II activity
E4341_RS09255	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4341_RS09260	COG0785	Cytochrome C biogenesis protein
E4341_RS09260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4341_RS09265	COG1381	Involved in DNA repair and RecF pathway recombination
E4341_RS09275	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4341_RS09290	COG0681	Belongs to the peptidase S26 family
E4341_RS09295	COG0736	holo-[acyl-carrier-protein] synthase activity
E4341_RS09310	COG1611	Belongs to the LOG family
E4341_RS09320	COG1758	RNA polymerase activity
E4341_RS09330	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E4341_RS09340	COG1573	uracil-dna glycosylase
E4341_RS09350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4341_RS09355	COG0741	lytic transglycosylase activity
E4341_RS09360	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E4341_RS09365	COG4139	cobalamin transport
E4341_RS09385	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4341_RS09385	COG0116	Belongs to the methyltransferase superfamily
E4341_RS09390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4341_RS09395	COG0477	Major facilitator Superfamily
E4341_RS09400	COG1643	Atp-dependent helicase
E4341_RS09405	COG0531	amino acid
E4341_RS09520	COG0783	Belongs to the Dps family
E4341_RS09545	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E4341_RS09565	COG0393	Putative heavy-metal-binding
E4341_RS09570	COG1902	pentaerythritol trinitrate reductase activity
E4341_RS09580	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4341_RS09605	COG0114	fumarate hydratase activity
E4341_RS09665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4341_RS09670	COG0386	Belongs to the glutathione peroxidase family
E4341_RS09675	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4341_RS09685	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4341_RS09685	COG0022	dehydrogenase e1 component
E4341_RS09690	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E4341_RS09700	COG0148	phosphopyruvate hydratase activity
E4341_RS09715	COG0110	maltose O-acetyltransferase activity
E4341_RS09720	COG0579	oxidoreductase
E4341_RS09725	COG2867	negative regulation of translational initiation
E4341_RS09735	COG0318	PFAM AMP-dependent synthetase and ligase
E4341_RS09735	COG0204	Acyl-transferase
E4341_RS09740	COG3384	dioxygenase
E4341_RS09745	COG0655	NAD(P)H dehydrogenase (quinone) activity
E4341_RS09765	COG3956	TIGRFAM MazG family protein
E4341_RS09775	COG0025	NhaP-type Na H and K H
E4341_RS09780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4341_RS09785	COG1923	regulation of RNA biosynthetic process
E4341_RS09790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4341_RS09795	COG2204	response regulator
E4341_RS09800	COG5000	phosphorelay sensor kinase activity
E4341_RS09805	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4341_RS09820	COG1546	Belongs to the CinA family
E4341_RS09820	COG1058	Belongs to the CinA family
E4341_RS09830	COG1295	ribonuclease BN
E4341_RS09840	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E4341_RS09845	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E4341_RS09850	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4341_RS09855	COG0321	lipoyl(octanoyl) transferase activity
E4341_RS09855	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E4341_RS09860	COG0084	hydrolase, TatD family'
E4341_RS09870	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4341_RS09885	COG0443	Heat shock 70 kDa protein
E4341_RS09890	COG1960	acyl-CoA dehydrogenase activity
E4341_RS09895	COG1960	acyl-CoA dehydrogenase activity
E4341_RS09900	COG0772	Belongs to the SEDS family
E4341_RS09935	COG0436	Aminotransferase
E4341_RS09945	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4341_RS09955	COG1862	Preprotein translocase
E4341_RS09980	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4341_RS09990	COG0006	proline dipeptidase activity
E4341_RS09990	COG0006	proline dipeptidase activity
E4341_RS09995	COG2264	protein methyltransferase activity
E4341_RS10005	COG0513	Belongs to the DEAD box helicase family
E4341_RS10025	COG0316	Belongs to the HesB IscA family
E4341_RS10030	COG2151	metal-sulfur cluster biosynthetic enzyme
E4341_RS10035	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4341_RS10040	COG0719	Fe-S assembly protein
E4341_RS10045	COG0396	ATPase activity
E4341_RS10050	COG0719	Fe-S assembly protein
E4341_RS10060	COG1959	2 iron, 2 sulfur cluster binding
E4341_RS10065	COG2945	thiolester hydrolase activity
E4341_RS10090	COG3876	Protein conserved in bacteria
E4341_RS10105	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4341_RS10110	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4341_RS10125	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E4341_RS10130	COG1764	response to oxidative stress
E4341_RS10145	COG1950	PFAM Membrane protein of
E4341_RS10150	COG0537	adenosine 5'-monophosphoramidase activity
E4341_RS10155	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
E4341_RS10170	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E4341_RS10175	COG1845	cytochrome c oxidase, subunit III
E4341_RS10180	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4341_RS10185	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4341_RS10190	COG0477	Major facilitator Superfamily
E4341_RS10210	COG4191	Histidine kinase
E4341_RS10215	COG2204	response regulator
E4341_RS10230	COG1304	FMN binding
E4341_RS10240	COG1131	(ABC) transporter
E4341_RS10290	COG1215	transferase activity, transferring glycosyl groups
E4341_RS10300	COG4529	Protein conserved in bacteria
E4341_RS10340	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4341_RS10345	COG0154	amidase activity
E4341_RS10350	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4341_RS10360	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E4341_RS10370	COG0540	Belongs to the ATCase OTCase family
E4341_RS10375	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4341_RS10380	COG0584	glycerophosphoryl diester phosphodiesterase
E4341_RS10390	COG0758	DNA mediated transformation
E4341_RS10400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4341_RS10400	COG1754	DNA topoisomerase type I activity
E4341_RS10420	COG0742	ribosomal rna small subunit methyltransferase
E4341_RS10425	COG3548	integral membrane protein
E4341_RS10435	COG1187	pseudouridine synthase activity
E4341_RS10440	COG0590	tRNA wobble adenosine to inosine editing
E4341_RS10450	COG2070	2-Nitropropane dioxygenase
E4341_RS10460	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4341_RS10470	COG4974	Belongs to the 'phage' integrase family
E4341_RS10490	COG2201	protein-glutamate methylesterase activity
E4341_RS10500	COG5265	(ABC) transporter
E4341_RS10510	COG0668	transmembrane transport
E4341_RS10515	COG1793	dna ligase
E4341_RS10525	COG2205	protein histidine kinase activity
E4341_RS10525	COG2198	Histidine kinase
E4341_RS10525	COG0784	Response regulator, receiver
E4341_RS10550	COG1530	ribonuclease E activity
E4341_RS10575	COG1131	(ABC) transporter
E4341_RS10595	COG0203	ribosomal protein L17
E4341_RS10605	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4341_RS10610	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4341_RS10625	COG0201	protein transport
E4341_RS10630	COG0200	Binds to the 23S rRNA
E4341_RS10645	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4341_RS10655	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4341_RS10660	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4341_RS10665	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4341_RS10675	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4341_RS10680	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4341_RS10685	COG0255	Belongs to the universal ribosomal protein uL29 family
E4341_RS10690	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4341_RS10695	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4341_RS10700	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4341_RS10705	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E4341_RS10710	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4341_RS10715	COG0089	rRNA binding
E4341_RS10725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4341_RS10730	COG0051	transcription antitermination factor activity, RNA binding
E4341_RS10760	COG1376	ErfK ybiS ycfS ynhG family protein
E4341_RS10765	COG2272	Belongs to the type-B carboxylesterase lipase family
E4341_RS10770	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4341_RS10785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4341_RS10790	COG0861	Integral membrane protein TerC family
E4341_RS10795	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4341_RS10810	COG0534	Mate efflux family protein
E4341_RS10835	COG1024	Enoyl-CoA hydratase
E4341_RS10840	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4341_RS10845	COG0360	Binds together with S18 to 16S ribosomal RNA
E4341_RS10850	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4341_RS10855	COG0359	binds to the 23S rRNA
E4341_RS10860	COG4771	TonB-dependent receptor
E4341_RS10880	COG0305	Participates in initiation and elongation during chromosome replication
E4341_RS10885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4341_RS10905	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4341_RS10910	COG1028	Short-chain dehydrogenase reductase Sdr
E4341_RS10915	COG0300	oxidoreductase activity
E4341_RS10920	COG2207	Transcriptional regulator
E4341_RS10930	COG1160	GTP binding
E4341_RS10975	COG1393	Belongs to the ArsC family
E4341_RS10995	COG4771	TonB-dependent receptor
E4341_RS11000	COG3842	ATPase activity
E4341_RS11010	COG0395	ABC-type sugar transport system, permease component
E4341_RS11015	COG1175	transmembrane transport
E4341_RS11020	COG1653	transport
E4341_RS11045	COG1024	Enoyl-CoA hydratase
E4341_RS11105	COG1937	Protein conserved in bacteria
E4341_RS11150	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E4341_RS11150	COG2755	lipolytic protein G-D-S-L family
E4341_RS11220	COG2217	Heavy metal translocating P-type atpase
E4341_RS11285	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4341_RS11295	COG0789	Transcriptional regulator
E4341_RS11300	COG2124	cytochrome p450
E4341_RS11310	COG0672	)-iron permease
E4341_RS11315	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4341_RS11315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4341_RS11330	COG0798	PFAM Bile acid sodium symporter
E4341_RS11370	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4341_RS11370	COG0519	Catalyzes the synthesis of GMP from XMP
E4341_RS11380	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4341_RS11380	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4341_RS11405	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4341_RS11415	COG0297	glycogen (starch) synthase activity
E4341_RS11415	COG0438	transferase activity, transferring glycosyl groups
E4341_RS11460	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4341_RS11470	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E4341_RS11485	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
E4341_RS11490	COG2807	transmembrane transport
E4341_RS11495	COG1846	Transcriptional regulator
E4341_RS11505	COG0142	geranyltranstransferase activity
E4341_RS11520	COG0343	queuine tRNA-ribosyltransferase activity
E4341_RS11540	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4341_RS11550	COG0729	surface antigen
E4341_RS11560	COG1393	Belongs to the ArsC family
E4341_RS11580	COG1012	belongs to the aldehyde dehydrogenase family
E4341_RS11585	COG3724	N-succinylarginine dihydrolase activity
E4341_RS11590	COG0477	Major facilitator Superfamily
E4341_RS11595	COG3186	Phenylalanine-4-hydroxylase
E4341_RS11605	COG0248	Ppx GppA phosphatase
E4341_RS11610	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4341_RS11630	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4341_RS11635	COG2032	superoxide dismutase activity
E4341_RS11650	COG0629	single-stranded DNA binding
E4341_RS11665	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4341_RS11680	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4341_RS11685	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4341_RS11690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4341_RS11695	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4341_RS11740	COG0617	tRNA 3'-terminal CCA addition
E4341_RS11760	COG1024	Enoyl-CoA hydratase
E4341_RS11790	COG0497	DNA recombination
E4341_RS11795	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4341_RS11815	COG2224	Isocitrate lyase
E4341_RS11840	COG2857	Cytochrome c1
E4341_RS11840	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E4341_RS11845	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E4341_RS11850	COG0723	plastoquinol--plastocyanin reductase activity
E4341_RS11855	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E4341_RS11865	COG0408	coproporphyrinogen oxidase activity
E4341_RS11875	COG2855	membrane
E4341_RS11880	COG0519	Catalyzes the synthesis of GMP from XMP
E4341_RS11885	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4341_RS11900	COG1063	alcohol dehydrogenase
E4341_RS11905	COG0156	8-amino-7-oxononanoate synthase activity
E4341_RS11915	COG0346	lactoylglutathione lyase activity
E4341_RS11930	COG4770	biotin carboxylase activity
E4341_RS11935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4341_RS11945	COG3800	Transcriptional regulator
E4341_RS11945	COG1396	sequence-specific DNA binding
E4341_RS11950	COG0673	inositol 2-dehydrogenase activity
E4341_RS11955	COG0469	pyruvate kinase activity
E4341_RS11965	COG2354	Protein conserved in bacteria
E4341_RS11970	COG0436	Aminotransferase
E4341_RS12005	COG4771	TonB-dependent receptor
E4341_RS12025	COG1028	Short-chain dehydrogenase reductase Sdr
E4341_RS12030	COG3387	PFAM Glycoside hydrolase 15-related
E4341_RS12035	COG1028	Short-chain dehydrogenase reductase Sdr
E4341_RS12040	COG1028	Short-chain dehydrogenase reductase Sdr
E4341_RS12055	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E4341_RS12070	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E4341_RS12075	COG1607	acyl-coa hydrolase
E4341_RS12095	COG4181	ATPase activity
E4341_RS12130	COG2211	Major facilitator Superfamily
E4341_RS12140	COG0477	Major facilitator Superfamily
E4341_RS12145	COG0475	glutathione-regulated potassium exporter activity
E4341_RS12150	COG1472	Belongs to the glycosyl hydrolase 3 family
E4341_RS12180	COG3655	Transcriptional regulator
E4341_RS12225	COG3284	Transcriptional regulator
E4341_RS12230	COG3047	cAMP biosynthetic process
E4341_RS12235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4341_RS12245	COG1294	oxidase, subunit
E4341_RS12260	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E4341_RS12265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4341_RS12340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4341_RS12365	COG0297	glycogen (starch) synthase activity
E4341_RS12390	COG1335	isochorismatase
E4341_RS12405	COG3546	catalase activity
E4341_RS12440	COG1335	isochorismatase
E4341_RS12540	COG4191	Histidine kinase
E4341_RS12545	COG4566	intracellular signal transduction
E4341_RS12595	COG0517	IMP dehydrogenase activity
E4341_RS12595	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E4341_RS12610	COG1462	curli production assembly transport component CsgG
E4341_RS12630	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4341_RS12635	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4341_RS12635	COG4651	solute:proton antiporter activity
E4341_RS12660	COG1028	Short-chain dehydrogenase reductase Sdr
E4341_RS12665	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E4341_RS12675	COG2030	dehydratase
E4341_RS12680	COG0196	riboflavin kinase activity
E4341_RS12690	COG1702	phosphate starvation-inducible protein PhoH
E4341_RS12695	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E4341_RS12735	COG2863	cytochrome
E4341_RS12740	COG3038	cytochrome b561
E4341_RS12750	COG0583	DNA-binding transcription factor activity
E4341_RS12755	COG2814	Major facilitator Superfamily
E4341_RS12765	COG0840	transmembrane signaling receptor activity
E4341_RS12775	COG0784	Response regulator, receiver
E4341_RS12775	COG2205	protein histidine kinase activity
E4341_RS12785	COG0840	transmembrane signaling receptor activity
E4341_RS12910	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4341_RS12915	COG5383	Protein conserved in bacteria
E4341_RS12935	COG1028	Short-chain dehydrogenase reductase Sdr
E4341_RS12960	COG1028	Short-chain dehydrogenase reductase Sdr
E4341_RS12985	COG0322	excinuclease ABC activity
E4341_RS12990	COG0288	reversible hydration of carbon dioxide
E4341_RS12995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4341_RS13015	COG1024	Enoyl-CoA hydratase
E4341_RS13020	COG1566	PFAM secretion protein HlyD family protein
E4341_RS13025	COG1136	(ABC) transporter
E4341_RS13040	COG3591	Belongs to the peptidase S1B family
E4341_RS13040	COG4990	cell redox homeostasis
E4341_RS13080	COG0438	transferase activity, transferring glycosyl groups
E4341_RS13095	COG1194	a g-specific adenine glycosylase
E4341_RS13110	COG0784	Response regulator, receiver
E4341_RS13120	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4341_RS13120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4341_RS13165	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4341_RS13180	COG0275	rRNA processing
E4341_RS13195	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4341_RS13205	COG0616	signal peptide processing
E4341_RS13210	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
E4341_RS13215	COG2968	Membrane
E4341_RS13260	COG1475	DNA binding
E4341_RS13390	COG1956	GAF domain-containing protein
E4341_RS13400	COG2301	Belongs to the HpcH HpaI aldolase family
E4341_RS13435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4341_RS13435	COG0574	Belongs to the PEP-utilizing enzyme family
E4341_RS13445	COG0751	glycine-tRNA ligase activity
E4341_RS13455	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
E4341_RS13475	COG1573	uracil-dna glycosylase
E4341_RS13480	COG1196	nuclear chromosome segregation
E4341_RS13480	COG0741	lytic transglycosylase activity
E4341_RS13480	COG0739	heme binding
E4341_RS13500	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4341_RS13520	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
E4341_RS13530	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4341_RS13535	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4341_RS13540	COG1881	PFAM PEBP family protein
E4341_RS13545	COG2814	Major facilitator Superfamily
E4341_RS13550	COG0047	phosphoribosylformylglycinamidine synthase activity
E4341_RS13585	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4341_RS13595	COG2124	cytochrome p450
E4341_RS13605	COG1692	metallophosphoesterase
E4341_RS13610	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4341_RS13635	COG0346	lactoylglutathione lyase activity
E4341_RS13640	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E4341_RS13645	COG1966	Carbon starvation protein
E4341_RS13655	COG0793	Belongs to the peptidase S41A family
E4341_RS13670	COG4771	TonB-dependent receptor
E4341_RS13680	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E4341_RS13710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4341_RS13725	COG0492	ferredoxin-NADP+ reductase activity
E4341_RS13730	COG0667	Aldo Keto reductase
E4341_RS13750	COG4191	Histidine kinase
E4341_RS13750	COG0784	Response regulator, receiver
E4341_RS13775	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E4341_RS13790	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4341_RS13795	COG0840	transmembrane signaling receptor activity
E4341_RS13815	COG2169	Transcriptional regulator
E4341_RS13840	COG0556	nucleotide-excision repair
E4341_RS13870	COG0513	Belongs to the DEAD box helicase family
E4341_RS13880	COG1546	Belongs to the CinA family
E4341_RS13880	COG1058	Belongs to the CinA family
E4341_RS13885	COG0024	Methionine aminopeptidase
E4341_RS13945	COG0583	DNA-binding transcription factor activity
E4341_RS13955	COG1271	oxidase subunit
E4341_RS13960	COG1294	oxidase, subunit
E4341_RS13970	COG3781	membrane
E4341_RS13975	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4341_RS14085	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4341_RS14110	COG3920	Histidine kinase
E4341_RS14125	COG0271	Belongs to the BolA IbaG family
E4341_RS14135	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E4341_RS14155	COG3300	MHYT domain
E4341_RS14155	COG5001	Diguanylate cyclase
E4341_RS14165	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4341_RS14175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4341_RS14180	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4341_RS14190	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E4341_RS14200	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E4341_RS14210	COG2885	chlorophyll binding
E4341_RS14220	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E4341_RS14230	COG3655	Transcriptional regulator
E4341_RS14240	COG0789	Transcriptional regulator
E4341_RS14245	COG1960	acyl-CoA dehydrogenase activity
E4341_RS14250	COG1960	acyl-CoA dehydrogenase activity
E4341_RS14255	COG2161	toxin-antitoxin pair type II binding
E4341_RS14260	COG4115	mRNA cleavage
E4341_RS14265	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4341_RS14280	COG0784	Response regulator, receiver
E4341_RS14280	COG5002	protein histidine kinase activity
E4341_RS14285	COG3609	addiction module antidote protein, CC2985 family
E4341_RS14320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4341_RS14340	COG0167	dihydroorotate dehydrogenase activity
E4341_RS14380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4341_RS14425	COG0659	secondary active sulfate transmembrane transporter activity
E4341_RS14435	COG1278	Cold shock
E4341_RS14445	COG0431	NADPH-dependent FMN reductase
E4341_RS14485	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E4341_RS14495	COG0109	protoheme IX farnesyltransferase activity
E4341_RS14500	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4341_RS14525	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E4341_RS14540	COG1476	TRANSCRIPTIONal
E4341_RS14555	COG2264	protein methyltransferase activity
E4341_RS14560	COG0693	protein deglycase activity
E4341_RS14570	COG2321	neutral zinc metallopeptidase
E4341_RS14600	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E4341_RS14620	COG0626	cystathionine gamma-synthase activity
E4341_RS14640	COG0505	Belongs to the CarA family
E4341_RS14660	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E4341_RS14665	COG4993	Dehydrogenase
E4341_RS14680	COG0004	ammonium transporteR
E4341_RS14685	COG0071	Belongs to the small heat shock protein (HSP20) family
E4341_RS14695	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4341_RS14700	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4341_RS14705	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E4341_RS14710	COG1137	ATPase activity
E4341_RS14735	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
E4341_RS14745	COG1596	polysaccharide export
E4341_RS14750	COG1677	Flagellar hook-basal body complex protein FliE
E4341_RS14755	COG1558	bacterial-type flagellum-dependent cell motility
E4341_RS14765	COG3190	flagellar
E4341_RS14770	COG1338	Plays a role in the flagellum-specific transport system
E4341_RS14775	COG0776	regulation of translation
E4341_RS14795	COG0351	phosphomethylpyrimidine kinase
E4341_RS14810	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4341_RS14840	COG0037	tRNA processing
E4341_RS14855	COG2885	chlorophyll binding
E4341_RS14860	COG0823	Involved in the tonB-independent uptake of proteins
E4341_RS14895	COG0824	Thioesterase
E4341_RS14915	COG2255	four-way junction helicase activity
E4341_RS14920	COG0632	four-way junction helicase activity
E4341_RS14925	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4341_RS14930	COG1285	pathogenesis
E4341_RS14940	COG0217	transcriptional regulatory protein
E4341_RS14950	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4341_RS14985	COG1506	peptidase
E4341_RS14995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4341_RS15020	COG2515	1-aminocyclopropane-1-carboxylate deaminase
E4341_RS15045	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E4341_RS15095	COG2205	protein histidine kinase activity
E4341_RS15100	COG0745	RESPONSE REGULATOR receiver
E4341_RS15120	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E4341_RS15125	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E4341_RS15140	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
E4341_RS15145	COG2205	protein histidine kinase activity
E4341_RS15150	COG0745	RESPONSE REGULATOR receiver
E4341_RS15155	COG0123	including yeast histone deacetylase and acetoin utilization protein
E4341_RS15175	COG0745	RESPONSE REGULATOR receiver
E4341_RS15185	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
E4341_RS15190	COG0745	RESPONSE REGULATOR receiver
E4341_RS15195	COG2201	protein-glutamate methylesterase activity
E4341_RS15200	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E4341_RS15205	COG0835	chemotaxis
E4341_RS15210	COG0643	Histidine kinase
E4341_RS15210	COG2198	Histidine kinase
E4341_RS15215	COG0745	RESPONSE REGULATOR receiver
E4341_RS15225	COG0840	transmembrane signaling receptor activity
E4341_RS15235	COG4191	Histidine kinase
E4341_RS15240	COG4566	intracellular signal transduction
E4341_RS15260	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4341_RS15275	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4341_RS15280	COG0308	aminopeptidase N
E4341_RS15295	COG4251	negative regulation of phosphorylation
E4341_RS15305	COG1278	Cold shock
E4341_RS15315	COG2326	polyphosphate kinase activity
E4341_RS15325	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4341_RS15330	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4341_RS15350	COG1396	sequence-specific DNA binding
E4341_RS15370	COG2197	response regulator
E4341_RS15375	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E4341_RS15385	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4341_RS15385	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4341_RS15390	COG0588	phosphoglycerate mutase activity
E4341_RS15400	COG0268	Binds directly to 16S ribosomal RNA