locus-tag	class	description
CPF12_RS00010	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CPF12_RS00015	COG1058	Belongs to the CinA family
CPF12_RS00015	COG1546	Belongs to the CinA family
CPF12_RS00020	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CPF12_RS00025	COG1426	Protein conserved in bacteria
CPF12_RS00030	COG0612	Peptidase, M16
CPF12_RS00040	COG1280	lysine exporter protein (LysE YggA)
CPF12_RS00040	COG1674	ftsk spoiiie
CPF12_RS00045	COG2378	regulation of single-species biofilm formation
CPF12_RS00065	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CPF12_RS00070	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CPF12_RS00085	COG0107	imidazoleglycerol-phosphate synthase activity
CPF12_RS00090	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CPF12_RS00105	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CPF12_RS00115	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CPF12_RS00135	COG0039	L-malate dehydrogenase activity
CPF12_RS00140	COG1620	l-lactate permease
CPF12_RS00165	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CPF12_RS00175	COG4869	propanediol catabolic process
CPF12_RS00185	COG1454	alcohol dehydrogenase
CPF12_RS00185	COG1012	belongs to the aldehyde dehydrogenase family
CPF12_RS00195	COG4816	utilization protein
CPF12_RS00200	COG4302	ethanolamine ammonia-lyase activity
CPF12_RS00205	COG4303	Ethanolamine ammonia lyase large subunit
CPF12_RS00210	COG4819	ethanolamine utilization protein
CPF12_RS00220	COG2201	protein-glutamate methylesterase activity
CPF12_RS00235	COG2096	Adenosyltransferase
CPF12_RS00245	COG2723	6-phospho-beta-galactosidase activity
CPF12_RS00250	COG2190	(PTS) system
CPF12_RS00250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPF12_RS00250	COG1263	PTS System
CPF12_RS00255	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CPF12_RS00260	COG1418	mRNA catabolic process
CPF12_RS00275	COG3842	ATPase activity
CPF12_RS00280	COG2207	Transcriptional regulator
CPF12_RS00280	COG4753	response regulator
CPF12_RS00285	COG2972	Histidine kinase
CPF12_RS00295	COG1653	transport
CPF12_RS00300	COG0395	ABC-type sugar transport system, permease component
CPF12_RS00305	COG1175	transmembrane transport
CPF12_RS00315	COG1609	Transcriptional regulator
CPF12_RS00325	COG0383	alpha-mannosidase activity
CPF12_RS00330	COG1940	carbohydrate kinase activity
CPF12_RS00345	COG2176	DNA-directed DNA polymerase activity
CPF12_RS00350	COG2076	Multidrug Resistance protein
CPF12_RS00355	COG2076	Multidrug Resistance protein
CPF12_RS00360	COG0383	alpha-mannosidase activity
CPF12_RS00365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPF12_RS00370	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPF12_RS00370	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CPF12_RS00370	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPF12_RS00375	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CPF12_RS00380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CPF12_RS00380	COG3711	transcriptional antiterminator
CPF12_RS00400	COG4221	oxidoreductase activity
CPF12_RS00405	COG1733	regulation of RNA biosynthetic process
CPF12_RS00410	COG1979	alcohol dehydrogenase
CPF12_RS00415	COG0328	RNA-DNA hybrid ribonuclease activity
CPF12_RS00415	COG3341	Caulimovirus viroplasmin
CPF12_RS00420	COG1132	(ABC) transporter
CPF12_RS00480	COG1174	glycine betaine transport
CPF12_RS00485	COG1125	glycine betaine transport
CPF12_RS00485	COG0517	IMP dehydrogenase activity
CPF12_RS00490	COG2315	Protein conserved in bacteria
CPF12_RS00505	COG1028	Short-chain dehydrogenase reductase Sdr
CPF12_RS00510	COG3275	phosphorelay sensor kinase activity
CPF12_RS00515	COG3279	Response regulator of the LytR AlgR family
CPF12_RS00530	COG1346	cytolysis
CPF12_RS00570	COG1595	DNA-templated transcription, initiation
CPF12_RS00655	COG1136	(ABC) transporter
CPF12_RS00655	COG0577	efflux transmembrane transporter activity
CPF12_RS00660	COG1136	(ABC) transporter
CPF12_RS00675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CPF12_RS00680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CPF12_RS00690	COG0488	(ABC) transporter
CPF12_RS00700	COG1349	DNA-binding transcription factor activity
CPF12_RS00710	COG1461	Dihydroxyacetone kinase
CPF12_RS00725	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CPF12_RS00730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPF12_RS00730	COG1263	PTS System
CPF12_RS00735	COG1737	Transcriptional regulator
CPF12_RS00745	COG0217	transcriptional regulatory protein
CPF12_RS00755	COG1027	Aspartate ammonia-lyase
CPF12_RS00780	COG0477	Major facilitator Superfamily
CPF12_RS00785	COG1846	Transcriptional regulator
CPF12_RS00795	COG1131	(ABC) transporter
CPF12_RS00825	COG0519	Catalyzes the synthesis of GMP from XMP
CPF12_RS00825	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CPF12_RS00835	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CPF12_RS00840	COG1970	mechanosensitive ion channel activity
CPF12_RS00845	COG1388	LysM domain
CPF12_RS00845	COG1705	Flagellar rod assembly protein muramidase FlgJ
CPF12_RS00855	COG1660	Displays ATPase and GTPase activities
CPF12_RS00860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CPF12_RS00865	COG0463	Glycosyl transferase, family 2
CPF12_RS00875	COG1134	teichoic acid transport
CPF12_RS00880	COG1682	transport, permease protein
CPF12_RS00885	COG0693	protein deglycase activity
CPF12_RS00890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CPF12_RS00895	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CPF12_RS00910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CPF12_RS00920	COG2190	(PTS) system
CPF12_RS00920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPF12_RS00920	COG1263	PTS System
CPF12_RS00930	COG1609	Transcriptional regulator
CPF12_RS00940	COG1876	peptidase activity
CPF12_RS00945	COG1079	Belongs to the binding-protein-dependent transport system permease family
CPF12_RS00950	COG4603	Belongs to the binding-protein-dependent transport system permease family
CPF12_RS00955	COG3845	ABC transporter
CPF12_RS00960	COG1744	ABC transporter substrate-binding protein PnrA-like
CPF12_RS00975	COG1254	Belongs to the acylphosphatase family
CPF12_RS00980	COG5002	protein histidine kinase activity
CPF12_RS00985	COG0745	RESPONSE REGULATOR receiver
CPF12_RS00990	COG0077	Prephenate dehydratase
CPF12_RS00995	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CPF12_RS01005	COG0133	tryptophan synthase activity
CPF12_RS01010	COG0135	phosphoribosylanthranilate isomerase activity
CPF12_RS01015	COG0134	indole-3-glycerol-phosphate synthase activity
CPF12_RS01020	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CPF12_RS01020	COG0512	Glutamine amidotransferase of anthranilate synthase
CPF12_RS01025	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CPF12_RS01035	COG2066	Belongs to the glutaminase family
CPF12_RS01040	COG1473	amidohydrolase
CPF12_RS01045	COG2271	Major facilitator Superfamily
CPF12_RS01050	COG4122	O-methyltransferase activity
CPF12_RS01055	COG2962	Rard protein
CPF12_RS01060	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CPF12_RS01065	COG2868	ribosomal protein
CPF12_RS01070	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CPF12_RS01075	COG0251	oxidation-reduction process
CPF12_RS01085	COG2894	cell division
CPF12_RS01090	COG0850	regulation of cytokinetic process
CPF12_RS01100	COG1792	Involved in formation and maintenance of cell shape
CPF12_RS01105	COG1077	Cell shape determining protein MreB Mrl
CPF12_RS01110	COG2003	Belongs to the UPF0758 family
CPF12_RS01120	COG0285	dihydrofolate synthase activity
CPF12_RS01125	COG0525	valine-tRNA ligase activity
CPF12_RS01130	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CPF12_RS01135	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CPF12_RS01140	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CPF12_RS01145	COG0544	peptidyl-prolyl cis-trans isomerase activity
CPF12_RS01215	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
CPF12_RS01320	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CPF12_RS01335	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CPF12_RS01375	COG0697	spore germination
CPF12_RS01400	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CPF12_RS01415	COG0561	phosphatase activity
CPF12_RS01425	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CPF12_RS01430	COG0569	domain protein
CPF12_RS01435	COG2197	response regulator
CPF12_RS01440	COG4585	Histidine kinase
CPF12_RS01445	COG4758	membrane
CPF12_RS01450	COG2996	Protein conserved in bacteria
CPF12_RS01460	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CPF12_RS01465	COG0510	thiamine kinase activity
CPF12_RS01470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CPF12_RS01475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CPF12_RS01480	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CPF12_RS01485	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CPF12_RS01495	COG1302	Protein conserved in bacteria
CPF12_RS01500	COG0439	Biotin carboxylase
CPF12_RS01505	COG0511	ligase activity, forming carbon-carbon bonds
CPF12_RS01510	COG0006	proline dipeptidase activity
CPF12_RS01515	COG3872	metal-dependent enzyme
CPF12_RS01520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CPF12_RS01525	COG0281	malic enzyme
CPF12_RS01530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CPF12_RS01535	COG0436	Aminotransferase
CPF12_RS01545	COG3425	synthase
CPF12_RS01550	COG0183	Belongs to the thiolase family
CPF12_RS01565	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CPF12_RS01575	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CPF12_RS01580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CPF12_RS01585	COG1459	type II secretion system
CPF12_RS01615	COG0826	peptidase U32
CPF12_RS01625	COG1940	carbohydrate kinase activity
CPF12_RS01635	COG0705	Rhomboid family
CPF12_RS01635	COG0457	Tetratricopeptide repeat
CPF12_RS01640	COG0137	argininosuccinate synthase activity
CPF12_RS01645	COG0165	Argininosuccinate lyase
CPF12_RS01655	COG1823	symporter activity
CPF12_RS01685	COG3620	sequence-specific DNA binding
CPF12_RS01690	COG1879	ABC-type sugar transport system periplasmic component
CPF12_RS01695	COG1172	Belongs to the binding-protein-dependent transport system permease family
CPF12_RS01700	COG1129	ABC transporter
CPF12_RS01705	COG1869	D-ribose catabolic process
CPF12_RS01710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CPF12_RS01720	COG1609	Transcriptional regulator
CPF12_RS01725	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CPF12_RS01730	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CPF12_RS01745	COG0768	penicillin binding
CPF12_RS01750	COG5521	maltodextrose utilization protein MalA
CPF12_RS01755	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CPF12_RS01760	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CPF12_RS01765	COG0640	Transcriptional regulator
CPF12_RS01775	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CPF12_RS01780	COG0124	histidyl-tRNA synthetase
CPF12_RS01785	COG1114	Component of the transport system for branched-chain amino acids
CPF12_RS01790	COG0508	dehydrogenase complex catalyzes the overall conversion of
CPF12_RS01795	COG0022	dehydrogenase e1 component
CPF12_RS01800	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CPF12_RS01805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CPF12_RS01815	COG0280	phosphate acetyltransferase
CPF12_RS01830	COG1490	D-aminoacyl-tRNA deacylase activity
CPF12_RS01835	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CPF12_RS01845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CPF12_RS01850	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CPF12_RS01850	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CPF12_RS01855	COG5416	Lipopolysaccharide assembly protein A domain
CPF12_RS01860	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CPF12_RS01860	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CPF12_RS01865	COG1862	Preprotein translocase
CPF12_RS01870	COG0343	queuine tRNA-ribosyltransferase activity
CPF12_RS01875	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CPF12_RS01880	COG2255	four-way junction helicase activity
CPF12_RS01890	COG1346	cytolysis
CPF12_RS01895	COG1380	Effector of murein hydrolase LrgA
CPF12_RS01910	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CPF12_RS01915	COG0066	3-isopropylmalate dehydratase activity
CPF12_RS01920	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CPF12_RS01925	COG0473	3-isopropylmalate dehydrogenase activity
CPF12_RS01930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CPF12_RS01935	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CPF12_RS01940	COG0440	acetolactate synthase activity
CPF12_RS01945	COG0028	Belongs to the TPP enzyme family
CPF12_RS01950	COG0129	dihydroxy-acid dehydratase activity
CPF12_RS01960	COG0671	phosphoesterase, PA-phosphatase related
CPF12_RS01965	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CPF12_RS01970	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CPF12_RS01975	COG3599	regulation of cell shape
CPF12_RS01985	COG0762	integral membrane protein
CPF12_RS01990	COG1799	cell septum assembly
CPF12_RS01995	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CPF12_RS02000	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CPF12_RS02005	COG0849	cell division
CPF12_RS02010	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CPF12_RS02015	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CPF12_RS02020	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CPF12_RS02035	COG0768	penicillin binding
CPF12_RS02040	COG4839	cell division protein FtsL
CPF12_RS02050	COG2001	Belongs to the MraZ family
CPF12_RS02065	COG1399	metal-binding, possibly nucleic acid-binding protein
CPF12_RS02075	COG3480	Lon protease (S16) C-terminal proteolytic domain
CPF12_RS02080	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CPF12_RS02085	COG0742	ribosomal rna small subunit methyltransferase
CPF12_RS02090	COG4471	UPF0298 protein
CPF12_RS02095	COG3679	Belongs to the UPF0342 family
CPF12_RS02105	COG0109	protoheme IX farnesyltransferase activity
CPF12_RS02110	COG1612	heme a metabolic process
CPF12_RS02115	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CPF12_RS02120	COG0772	Belongs to the SEDS family
CPF12_RS02135	COG1217	gtp-binding protein TYPA
CPF12_RS02140	COG0483	inositol monophosphate 1-phosphatase activity
CPF12_RS02145	COG4493	Belongs to the UPF0637 family
CPF12_RS02160	COG2267	carboxylic ester hydrolase activity
CPF12_RS02165	COG4476	Belongs to the UPF0223 family
CPF12_RS02180	COG1120	ATPase activity
CPF12_RS02195	COG0508	dehydrogenase complex catalyzes the overall conversion of
CPF12_RS02200	COG0022	dehydrogenase e1 component
CPF12_RS02210	COG0242	peptide deformylase activity
CPF12_RS02220	COG2918	glutathione biosynthetic process
CPF12_RS02220	COG0189	ligase activity
CPF12_RS02225	COG4166	transmembrane transport
CPF12_RS02230	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CPF12_RS02235	COG0488	(ABC) transporter
CPF12_RS02260	COG1131	(ABC) transporter
CPF12_RS02270	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CPF12_RS02275	COG0114	fumarate hydratase activity
CPF12_RS02280	COG0456	acetyltransferase
CPF12_RS02285	COG1214	PFAM Peptidase M22, glycoprotease
CPF12_RS02290	COG0802	atpase or kinase
CPF12_RS02295	COG0772	Belongs to the SEDS family
CPF12_RS02345	COG3118	belongs to the thioredoxin family
CPF12_RS02350	COG1193	negative regulation of DNA recombination
CPF12_RS02365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CPF12_RS02365	COG0072	phenylalanine-tRNA ligase activity
CPF12_RS02370	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CPF12_RS02375	COG1733	regulation of RNA biosynthetic process
CPF12_RS02380	COG0756	dUTP diphosphatase activity
CPF12_RS02385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CPF12_RS02395	COG1304	FMN binding
CPF12_RS02400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CPF12_RS02400	COG0551	DNA topoisomerase type I activity
CPF12_RS02440	COG0438	transferase activity, transferring glycosyl groups
CPF12_RS02445	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CPF12_RS02445	COG1215	transferase activity, transferring glycosyl groups
CPF12_RS02455	COG1609	Transcriptional regulator
CPF12_RS02460	COG3459	Glycosyltransferase 36 associated
CPF12_RS02470	COG1653	transport
CPF12_RS02475	COG1175	transmembrane transport
CPF12_RS02480	COG0395	ABC-type sugar transport system, permease component
CPF12_RS02485	COG3842	ATPase activity
CPF12_RS02495	COG0415	Belongs to the DNA photolyase family
CPF12_RS02505	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CPF12_RS02510	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CPF12_RS02515	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CPF12_RS02520	COG0726	polysaccharide deacetylase
CPF12_RS02525	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CPF12_RS02530	COG0861	Integral membrane protein TerC family
CPF12_RS02535	COG0861	Integral membrane protein TerC family
CPF12_RS02550	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CPF12_RS02555	COG1363	Peptidase, m42
CPF12_RS02560	COG0477	Major facilitator Superfamily
CPF12_RS02575	COG0656	L-ascorbic acid biosynthetic process
CPF12_RS02585	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CPF12_RS02595	COG0564	pseudouridine synthase activity
CPF12_RS02605	COG2357	RelA SpoT domain protein
CPF12_RS02625	COG4116	CYTH
CPF12_RS02630	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CPF12_RS02635	COG0248	Ppx GppA phosphatase
CPF12_RS02640	COG2755	lipolytic protein G-D-S-L family
CPF12_RS02640	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CPF12_RS02645	COG0768	penicillin binding
CPF12_RS02650	COG1126	abc transporter atp-binding protein
CPF12_RS02655	COG0765	amino acid transport
CPF12_RS02660	COG1164	Oligoendopeptidase f
CPF12_RS02675	COG4862	establishment of competence for transformation
CPF12_RS02680	COG1393	Belongs to the ArsC family
CPF12_RS02685	COG0180	Tryptophanyl-tRNA synthetase
CPF12_RS02690	COG0386	Belongs to the glutathione peroxidase family
CPF12_RS02705	COG1129	ABC transporter
CPF12_RS02720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CPF12_RS02735	COG0588	phosphoglycerate mutase activity
CPF12_RS02780	COG0602	queuosine metabolic process
CPF12_RS02785	COG1328	CTP reductase activity
CPF12_RS02790	COG2151	metal-sulfur cluster biosynthetic enzyme
CPF12_RS02795	COG0561	phosphatase activity
CPF12_RS02830	COG0778	Nitroreductase
CPF12_RS02835	COG0095	Lipoate-protein ligase
CPF12_RS02845	COG4473	ABC transporter
CPF12_RS02850	COG1131	(ABC) transporter
CPF12_RS02855	COG0537	adenosine 5'-monophosphoramidase activity
CPF12_RS02860	COG4980	gas vesicle protein
CPF12_RS02870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CPF12_RS02875	COG3481	metal-dependent phosphohydrolase, HD sub domain
CPF12_RS02880	COG4717	serine-type aminopeptidase activity
CPF12_RS02885	COG0420	3'-5' exonuclease activity
CPF12_RS02890	COG3679	Belongs to the UPF0342 family
CPF12_RS02895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CPF12_RS02910	COG0564	pseudouridine synthase activity
CPF12_RS02915	COG0656	L-ascorbic acid biosynthetic process
CPF12_RS02920	COG1392	Phosphate transport regulator
CPF12_RS02925	COG0306	phosphate transporter
CPF12_RS02935	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CPF12_RS02945	COG1914	H( )-stimulated, divalent metal cation uptake system
CPF12_RS02950	COG1396	sequence-specific DNA binding
CPF12_RS02960	COG1011	Hydrolase
CPF12_RS02970	COG1126	abc transporter atp-binding protein
CPF12_RS02975	COG0765	amino acid transport
CPF12_RS02980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CPF12_RS02985	COG1252	NADH dehydrogenase
CPF12_RS02995	COG2153	protein acetylation
CPF12_RS03000	COG0656	L-ascorbic acid biosynthetic process
CPF12_RS03005	COG2814	Major facilitator Superfamily
CPF12_RS03010	COG0431	NADPH-dependent FMN reductase
CPF12_RS03065	COG2814	Major facilitator Superfamily
CPF12_RS03080	COG0346	lactoylglutathione lyase activity
CPF12_RS03090	COG0346	lactoylglutathione lyase activity
CPF12_RS03110	COG0604	alcohol dehydrogenase
CPF12_RS03125	COG1522	sequence-specific DNA binding
CPF12_RS03135	COG1959	2 iron, 2 sulfur cluster binding
CPF12_RS03140	COG0604	alcohol dehydrogenase
CPF12_RS03155	COG2814	Major facilitator Superfamily
CPF12_RS03165	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CPF12_RS03170	COG0110	maltose O-acetyltransferase activity
CPF12_RS03220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CPF12_RS03240	COG0534	Mate efflux family protein
CPF12_RS03245	COG1309	transcriptional regulator
CPF12_RS03250	COG0028	Belongs to the TPP enzyme family
CPF12_RS03260	COG0688	phosphatidylethanolamine metabolic process
CPF12_RS03265	COG0586	Pfam SNARE associated Golgi protein
CPF12_RS03270	COG1183	phosphatidylcholine synthase activity
CPF12_RS03285	COG0673	inositol 2-dehydrogenase activity
CPF12_RS03290	COG1854	S-ribosylhomocysteine lyase activity
CPF12_RS03295	COG3142	Participates in the control of copper homeostasis
CPF12_RS03315	COG1447	Phosphotransferase system cellobiose-specific component IIA
CPF12_RS03320	COG1940	carbohydrate kinase activity
CPF12_RS03325	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CPF12_RS03335	COG2723	6-phospho-beta-galactosidase activity
CPF12_RS03345	COG1132	(ABC) transporter
CPF12_RS03385	COG2706	6-phosphogluconolactonase activity
CPF12_RS03400	COG2363	Small membrane protein
CPF12_RS03405	COG0280	phosphate acetyltransferase
CPF12_RS03415	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CPF12_RS03420	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CPF12_RS03425	COG3253	May function as heme-dependent peroxidase
CPF12_RS03430	COG0561	phosphatase activity
CPF12_RS03435	COG0351	phosphomethylpyrimidine kinase
CPF12_RS03440	COG2322	membrane
CPF12_RS03450	COG1054	Belongs to the UPF0176 family
CPF12_RS03575	COG1272	protein, Hemolysin III
CPF12_RS03580	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CPF12_RS03590	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CPF12_RS03595	COG0626	cystathionine gamma-synthase activity
CPF12_RS03600	COG0626	cystathionine gamma-synthase activity
CPF12_RS03605	COG0646	methionine synthase
CPF12_RS03605	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CPF12_RS03610	COG0628	permease
CPF12_RS03615	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CPF12_RS03635	COG0561	phosphatase activity
CPF12_RS03640	COG0561	phosphatase activity
CPF12_RS03650	COG0436	Aminotransferase
CPF12_RS03655	COG4485	Bacterial membrane protein, YfhO
CPF12_RS03660	COG4549	nuclear export factor GLE1
CPF12_RS03665	COG1276	copper resistance
CPF12_RS03665	COG2372	response to copper ion
CPF12_RS03670	COG1349	DNA-binding transcription factor activity
CPF12_RS03685	COG1278	Cold shock
CPF12_RS03690	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CPF12_RS03700	COG4166	transmembrane transport
CPF12_RS03705	COG4166	transmembrane transport
CPF12_RS03710	COG4608	Belongs to the ABC transporter superfamily
CPF12_RS03715	COG0444	Belongs to the ABC transporter superfamily
CPF12_RS03720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CPF12_RS03725	COG0601	transmembrane transport
CPF12_RS03735	COG0588	phosphoglycerate mutase activity
CPF12_RS03740	COG2357	RelA SpoT domain protein
CPF12_RS03755	COG2252	PERMEase
CPF12_RS03770	COG0701	Predicted permease
CPF12_RS03775	COG3689	TIGRFAM TIGR03943 family protein
CPF12_RS03830	COG1388	LysM domain
CPF12_RS03830	COG3584	3D domain protein
CPF12_RS03845	COG1464	Belongs to the NlpA lipoprotein family
CPF12_RS03870	COG2365	Tyrosine phosphatase family
CPF12_RS03875	COG2376	Dihydroxyacetone kinase
CPF12_RS03880	COG1461	Dihydroxyacetone kinase
CPF12_RS03885	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CPF12_RS03895	COG1473	amidohydrolase
CPF12_RS03910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CPF12_RS03915	COG1121	(ABC) transporter
CPF12_RS03920	COG4166	transmembrane transport
CPF12_RS03925	COG4166	transmembrane transport
CPF12_RS03930	COG0531	amino acid
CPF12_RS03935	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CPF12_RS03950	COG2059	Chromate
CPF12_RS03955	COG2059	Chromate
CPF12_RS03975	COG2011	ABC-type metal ion transport system permease component
CPF12_RS03980	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CPF12_RS03985	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CPF12_RS03995	COG1482	cell wall glycoprotein biosynthetic process
CPF12_RS04000	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CPF12_RS04000	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CPF12_RS04010	COG3715	PTS system
CPF12_RS04015	COG3716	PTS system mannose fructose sorbose family IID component
CPF12_RS04070	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CPF12_RS04080	COG1136	(ABC) transporter
CPF12_RS04095	COG1120	ATPase activity
CPF12_RS04100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPF12_RS04105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPF12_RS04110	COG0492	ferredoxin-NADP+ reductase activity
CPF12_RS04115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CPF12_RS04125	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CPF12_RS04135	COG2723	6-phospho-beta-galactosidase activity
CPF12_RS04140	COG2116	formate transmembrane transporter activity
CPF12_RS04145	COG4989	oxidoreductase activity
CPF12_RS04155	COG1301	dicarboxylic acid transport
CPF12_RS04170	COG1725	Transcriptional regulator
CPF12_RS04175	COG4555	ABC transporter
CPF12_RS04185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CPF12_RS04195	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CPF12_RS04205	COG2211	Major facilitator Superfamily
CPF12_RS04215	COG1940	carbohydrate kinase activity
CPF12_RS04240	COG1033	growth of symbiont in host cell
CPF12_RS04240	COG2409	Drug exporters of the RND superfamily
CPF12_RS04245	COG1263	PTS System
CPF12_RS04245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPF12_RS04250	COG2190	(PTS) system
CPF12_RS04250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPF12_RS04250	COG1263	PTS System
CPF12_RS04280	COG1705	Flagellar rod assembly protein muramidase FlgJ
CPF12_RS04295	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CPF12_RS04310	COG3842	ATPase activity
CPF12_RS04320	COG1177	transmembrane transport
CPF12_RS04340	COG2723	6-phospho-beta-galactosidase activity
CPF12_RS04345	COG2723	6-phospho-beta-galactosidase activity
CPF12_RS04350	COG1263	PTS System
CPF12_RS04350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPF12_RS04350	COG2190	(PTS) system
CPF12_RS04355	COG1263	PTS System
CPF12_RS04355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPF12_RS04355	COG2190	(PTS) system
CPF12_RS04360	COG3711	transcriptional antiterminator
CPF12_RS04365	COG2233	PERMEase
CPF12_RS04370	COG1063	alcohol dehydrogenase
CPF12_RS04375	COG0252	asparaginase activity
CPF12_RS04380	COG2190	(PTS) system
CPF12_RS04380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPF12_RS04380	COG1263	PTS System
CPF12_RS04385	COG3711	transcriptional antiterminator
CPF12_RS04390	COG2824	Alkylphosphonate utilization operon protein PhnA
CPF12_RS04405	COG4753	response regulator
CPF12_RS04405	COG2207	Transcriptional regulator
CPF12_RS04410	COG2972	Histidine kinase
CPF12_RS04420	COG3842	ATPase activity
CPF12_RS04425	COG1840	ABC-type Fe3 transport system, periplasmic component
CPF12_RS04430	COG1757	Na H antiporter
CPF12_RS04450	COG1033	growth of symbiont in host cell
CPF12_RS04450	COG2409	Drug exporters of the RND superfamily
CPF12_RS04460	COG0583	DNA-binding transcription factor activity
CPF12_RS04465	COG0431	NADPH-dependent FMN reductase
CPF12_RS04470	COG0454	-acetyltransferase
CPF12_RS04475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CPF12_RS04480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CPF12_RS04485	COG0765	amino acid transport
CPF12_RS04490	COG0765	amino acid transport
CPF12_RS04495	COG1126	abc transporter atp-binding protein
CPF12_RS04500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CPF12_RS04505	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CPF12_RS04510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CPF12_RS04525	COG0352	thiamine-phosphate diphosphorylase activity
CPF12_RS04530	COG0351	phosphomethylpyrimidine kinase
CPF12_RS04545	COG2807	transmembrane transport
CPF12_RS04555	COG2246	polysaccharide biosynthetic process
CPF12_RS04585	COG1136	(ABC) transporter
CPF12_RS04610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CPF12_RS04620	COG3961	Belongs to the TPP enzyme family
CPF12_RS04630	COG0583	DNA-binding transcription factor activity
CPF12_RS04635	COG5002	protein histidine kinase activity
CPF12_RS04635	COG3850	Histidine kinase
CPF12_RS04640	COG0745	RESPONSE REGULATOR receiver
CPF12_RS04645	COG1705	Flagellar rod assembly protein muramidase FlgJ
CPF12_RS04650	COG4807	Protein conserved in bacteria
CPF12_RS04655	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CPF12_RS04670	COG0346	lactoylglutathione lyase activity
CPF12_RS04675	COG0110	maltose O-acetyltransferase activity
CPF12_RS04695	COG4335	DNA alkylation repair
CPF12_RS04700	COG0488	(ABC) transporter
CPF12_RS04710	COG0659	secondary active sulfate transmembrane transporter activity
CPF12_RS04715	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CPF12_RS04725	COG2153	protein acetylation
CPF12_RS04735	COG2188	Transcriptional regulator
CPF12_RS04740	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CPF12_RS04745	COG2723	6-phospho-beta-galactosidase activity
CPF12_RS04750	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CPF12_RS04755	COG3711	transcriptional antiterminator
CPF12_RS04760	COG1263	PTS System
CPF12_RS04760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPF12_RS04760	COG2190	(PTS) system
CPF12_RS04785	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CPF12_RS04790	COG1368	sulfuric ester hydrolase activity
CPF12_RS04805	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CPF12_RS04810	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CPF12_RS04810	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CPF12_RS04815	COG0307	riboflavin synthase, alpha
CPF12_RS04820	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CPF12_RS04820	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CPF12_RS04885	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CPF12_RS04895	COG1408	metallophosphoesterase
CPF12_RS04900	COG0191	fructose-bisphosphate aldolase activity
CPF12_RS04905	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPF12_RS04905	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPF12_RS04910	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPF12_RS04915	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CPF12_RS04915	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPF12_RS04915	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPF12_RS04930	COG0583	DNA-binding transcription factor activity
CPF12_RS04955	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CPF12_RS04970	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CPF12_RS04970	COG0463	Glycosyl transferase, family 2
CPF12_RS04980	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CPF12_RS04990	COG0577	efflux transmembrane transporter activity
CPF12_RS04995	COG1136	(ABC) transporter
CPF12_RS05000	COG5002	protein histidine kinase activity
CPF12_RS05005	COG0745	RESPONSE REGULATOR receiver
CPF12_RS05015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CPF12_RS05020	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CPF12_RS05035	COG5002	protein histidine kinase activity
CPF12_RS05040	COG0745	RESPONSE REGULATOR receiver
CPF12_RS05045	COG4607	ABC-type enterochelin transport system periplasmic component
CPF12_RS05050	COG4604	ABC transporter, ATP-binding protein
CPF12_RS05055	COG4605	iron ion homeostasis
CPF12_RS05060	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPF12_RS05090	COG0640	Transcriptional regulator
CPF12_RS05095	COG0803	Belongs to the bacterial solute-binding protein 9 family
CPF12_RS05100	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CPF12_RS05110	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CPF12_RS05135	COG3684	Belongs to the aldolase LacD family
CPF12_RS05140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPF12_RS05140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPF12_RS05140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CPF12_RS05155	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CPF12_RS05160	COG4720	Psort location CytoplasmicMembrane, score
CPF12_RS05165	COG0436	Aminotransferase
CPF12_RS05180	COG0346	lactoylglutathione lyase activity
CPF12_RS05185	COG0400	carboxylic ester hydrolase activity
CPF12_RS05190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CPF12_RS05205	COG1114	Component of the transport system for branched-chain amino acids
CPF12_RS05210	COG0475	glutathione-regulated potassium exporter activity
CPF12_RS05220	COG0583	DNA-binding transcription factor activity
CPF12_RS05225	COG0039	L-malate dehydrogenase activity
CPF12_RS05245	COG1196	nuclear chromosome segregation
CPF12_RS05245	COG0739	heme binding
CPF12_RS05245	COG0741	lytic transglycosylase activity
CPF12_RS05260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CPF12_RS05270	COG2211	Major facilitator Superfamily
CPF12_RS05280	COG3655	Transcriptional regulator
CPF12_RS05295	COG2169	Transcriptional regulator
CPF12_RS05310	COG0028	Belongs to the TPP enzyme family
CPF12_RS05325	COG4990	cell redox homeostasis
CPF12_RS05335	COG0246	Mannitol dehydrogenase
CPF12_RS05345	COG2814	Major facilitator Superfamily
CPF12_RS05350	COG0305	Participates in initiation and elongation during chromosome replication
CPF12_RS05365	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CPF12_RS05375	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CPF12_RS05380	COG0629	single-stranded DNA binding
CPF12_RS05395	COG1012	belongs to the aldehyde dehydrogenase family
CPF12_RS05400	COG1396	sequence-specific DNA binding
CPF12_RS05410	COG0012	GTP binding
CPF12_RS05420	COG1316	TRANSCRIPTIONal
CPF12_RS05430	COG1316	TRANSCRIPTIONal
CPF12_RS05435	COG4481	Protein conserved in bacteria
CPF12_RS05440	COG1475	DNA binding
CPF12_RS05445	COG1192	Involved in chromosome partitioning
CPF12_RS05450	COG3620	sequence-specific DNA binding
CPF12_RS05460	COG1475	DNA binding
CPF12_RS05465	COG0357	Ribosomal RNA small subunit methyltransferase G
CPF12_RS05470	COG0445	tRNA wobble uridine modification
CPF12_RS05475	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CPF12_RS05485	COG0594	ribonuclease P activity
CPF12_RS05495	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CPF12_RS05500	COG0592	DNA-directed DNA polymerase activity
CPF12_RS05505	COG3620	sequence-specific DNA binding
CPF12_RS05520	COG2501	S4 domain
CPF12_RS05525	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CPF12_RS05530	COG0187	DNA topoisomerase II activity
CPF12_RS05535	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CPF12_RS05550	COG1845	cytochrome c oxidase, subunit III
CPF12_RS05555	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CPF12_RS05565	COG0516	GMP reductase activity
CPF12_RS05565	COG0517	IMP dehydrogenase activity
CPF12_RS05575	COG1686	Belongs to the peptidase S11 family
CPF12_RS05585	COG0406	alpha-ribazole phosphatase activity
CPF12_RS05590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CPF12_RS05595	COG0590	tRNA wobble adenosine to inosine editing
CPF12_RS05605	COG1271	oxidase subunit
CPF12_RS05610	COG1294	oxidase, subunit
CPF12_RS05615	COG4988	ABC transporter
CPF12_RS05620	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CPF12_RS05640	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CPF12_RS05645	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CPF12_RS05650	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CPF12_RS05665	COG3870	Protein conserved in bacteria
CPF12_RS05670	COG3104	oligopeptide transport
CPF12_RS05675	COG0470	DNA polymerase III
CPF12_RS05680	COG1774	PSP1 C-terminal conserved region
CPF12_RS05685	COG4467	Involved in initiation control of chromosome replication
CPF12_RS05690	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CPF12_RS05695	COG2827	Endonuclease containing a URI domain
CPF12_RS05700	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CPF12_RS05710	COG0084	hydrolase, TatD family'
CPF12_RS05715	COG1388	LysM domain
CPF12_RS05715	COG3584	3D domain protein
CPF12_RS05720	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CPF12_RS05725	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CPF12_RS05730	COG4466	Protein conserved in bacteria
CPF12_RS05735	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CPF12_RS05740	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CPF12_RS05750	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CPF12_RS05755	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CPF12_RS05760	COG0039	L-malate dehydrogenase activity
CPF12_RS05765	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CPF12_RS05775	COG0193	aminoacyl-tRNA hydrolase activity
CPF12_RS05780	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CPF12_RS05785	COG2244	polysaccharide biosynthetic process
CPF12_RS05790	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CPF12_RS05800	COG1098	S1 RNA binding domain
CPF12_RS05805	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CPF12_RS05805	COG0037	tRNA processing
CPF12_RS05810	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CPF12_RS05810	COG0037	tRNA processing
CPF12_RS05815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CPF12_RS05825	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CPF12_RS05830	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CPF12_RS05835	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CPF12_RS05920	COG0542	response to heat
CPF12_RS05925	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CPF12_RS05930	COG4956	integral membrane protein (PIN domain superfamily)
CPF12_RS05935	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CPF12_RS05940	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CPF12_RS05945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CPF12_RS05950	COG1045	serine acetyltransferase
CPF12_RS05955	COG0215	cysteine-tRNA ligase activity
CPF12_RS05965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CPF12_RS05970	COG3688	RNA-binding protein containing a PIN domain
CPF12_RS05975	COG1595	DNA-templated transcription, initiation
CPF12_RS05985	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CPF12_RS05990	COG0250	Participates in transcription elongation, termination and antitermination
CPF12_RS05995	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CPF12_RS06000	COG0081	regulation of translation
CPF12_RS06010	COG0222	ribosome binding
CPF12_RS06015	COG2813	Specifically methylates the guanine in position
CPF12_RS06035	COG0049	tRNA binding
CPF12_RS06040	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CPF12_RS06055	COG0051	transcription antitermination factor activity, RNA binding
CPF12_RS06060	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CPF12_RS06070	COG0089	rRNA binding
CPF12_RS06075	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CPF12_RS06080	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CPF12_RS06085	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CPF12_RS06090	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CPF12_RS06095	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CPF12_RS06100	COG0255	Belongs to the universal ribosomal protein uL29 family
CPF12_RS06105	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CPF12_RS06110	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CPF12_RS06115	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CPF12_RS06125	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CPF12_RS06140	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CPF12_RS06145	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CPF12_RS06160	COG0201	protein transport
CPF12_RS06165	COG0563	adenylate kinase activity
CPF12_RS06170	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CPF12_RS06175	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CPF12_RS06190	COG0202	RNA polymerase activity
CPF12_RS06195	COG0203	ribosomal protein L17
CPF12_RS06205	COG1122	ATPase activity
CPF12_RS06210	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CPF12_RS06215	COG0101	tRNA pseudouridine synthase activity
CPF12_RS06220	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CPF12_RS06225	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CPF12_RS06230	COG1694	Mazg nucleotide pyrophosphohydrolase
CPF12_RS06245	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CPF12_RS06250	COG1263	PTS System
CPF12_RS06250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPF12_RS06260	COG1737	Transcriptional regulator
CPF12_RS06275	COG1122	ATPase activity
CPF12_RS06285	COG1268	BioY protein
CPF12_RS06290	COG0768	penicillin binding
CPF12_RS06350	COG1473	amidohydrolase
CPF12_RS06355	COG2514	catechol 2,3-dioxygenase activity
CPF12_RS06375	COG0095	Lipoate-protein ligase
CPF12_RS06380	COG1078	dGTPase activity
CPF12_RS06390	COG1942	4-Oxalocrotonate Tautomerase
CPF12_RS06400	COG0018	arginyl-trna synthetase
CPF12_RS06420	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CPF12_RS06425	COG0254	rRNA binding
CPF12_RS06430	COG1435	thymidine kinase activity
CPF12_RS06435	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CPF12_RS06440	COG2890	protein-(glutamine-N5) methyltransferase activity
CPF12_RS06445	COG0009	L-threonylcarbamoyladenylate synthase
CPF12_RS06450	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CPF12_RS06455	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CPF12_RS06460	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CPF12_RS06475	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CPF12_RS06480	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CPF12_RS06485	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CPF12_RS06490	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CPF12_RS06495	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CPF12_RS06505	COG4836	Membrane
CPF12_RS06510	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CPF12_RS06515	COG1077	Cell shape determining protein MreB Mrl
CPF12_RS06530	COG4948	Mandelate Racemase Muconate Lactonizing
CPF12_RS06535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CPF12_RS06560	COG4464	protein tyrosine phosphatase activity
CPF12_RS06565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CPF12_RS06570	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CPF12_RS06575	COG1215	transferase activity, transferring glycosyl groups
CPF12_RS06600	COG2244	polysaccharide biosynthetic process
CPF12_RS06605	COG1316	TRANSCRIPTIONal
CPF12_RS06615	COG1739	Uncharacterized protein family UPF0029
CPF12_RS06625	COG1307	EDD domain protein, DegV family
CPF12_RS06630	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CPF12_RS06645	COG0653	protein targeting
CPF12_RS06655	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CPF12_RS06660	COG2884	Cell division ATP-binding protein ftsE
CPF12_RS06665	COG2177	Part of the ABC transporter FtsEX involved in
CPF12_RS06670	COG0791	NLP P60 protein
CPF12_RS06670	COG1388	LysM domain
CPF12_RS06670	COG3103	Sh3 type 3 domain protein
CPF12_RS06675	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CPF12_RS06680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CPF12_RS06685	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CPF12_RS06690	COG0745	RESPONSE REGULATOR receiver
CPF12_RS06695	COG5002	protein histidine kinase activity
CPF12_RS06700	COG0573	inorganic phosphate transmembrane transporter activity
CPF12_RS06705	COG0581	inorganic phosphate transmembrane transporter activity
CPF12_RS06715	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CPF12_RS06720	COG0704	Plays a role in the regulation of phosphate uptake
CPF12_RS06740	COG0556	nucleotide-excision repair
CPF12_RS06745	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CPF12_RS06755	COG3595	metallopeptidase activity
CPF12_RS06760	COG1983	PspC domain protein
CPF12_RS06765	COG1950	PFAM Membrane protein of
CPF12_RS06775	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CPF12_RS06780	COG1012	belongs to the aldehyde dehydrogenase family
CPF12_RS06790	COG0492	ferredoxin-NADP+ reductase activity
CPF12_RS06810	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CPF12_RS06815	COG1481	regulation of sporulation
CPF12_RS06820	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CPF12_RS06825	COG0584	glycerophosphoryl diester phosphodiesterase
CPF12_RS06835	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CPF12_RS06845	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CPF12_RS06850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPF12_RS06850	COG1263	PTS System
CPF12_RS06855	COG0740	serine-type endopeptidase activity
CPF12_RS06860	COG0366	Alpha amylase catalytic
CPF12_RS06865	COG2188	Transcriptional regulator
CPF12_RS06900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CPF12_RS06905	COG0126	phosphoglycerate kinase activity
CPF12_RS06925	COG1393	Belongs to the ArsC family
CPF12_RS06965	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CPF12_RS06970	COG4844	belongs to the
CPF12_RS06975	COG4837	Protein of unknown function (DUF1462)
CPF12_RS06980	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CPF12_RS06990	COG0534	Mate efflux family protein
CPF12_RS06995	COG0628	permease
CPF12_RS07000	COG1227	inorganic diphosphatase activity
CPF12_RS07005	COG1121	(ABC) transporter
CPF12_RS07010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CPF12_RS07015	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CPF12_RS07030	COG0710	3-dehydroquinate dehydratase activity
CPF12_RS07035	COG1247	-acetyltransferase
CPF12_RS07045	COG1113	amino acid transport
CPF12_RS07055	COG0492	ferredoxin-NADP+ reductase activity
CPF12_RS07060	COG1252	NADH dehydrogenase
CPF12_RS07065	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CPF12_RS07070	COG1320	monovalent cation:proton antiporter activity
CPF12_RS07075	COG2212	antiporter activity
CPF12_RS07080	COG1863	multisubunit Na H antiporter MnhE subunit
CPF12_RS07090	COG1006	Multisubunit Na H antiporter MnhC subunit
CPF12_RS07095	COG2111	Na H antiporter
CPF12_RS07100	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CPF12_RS07100	COG2111	Na H antiporter
CPF12_RS07105	COG2814	Major facilitator Superfamily
CPF12_RS07110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CPF12_RS07115	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CPF12_RS07120	COG1098	S1 RNA binding domain
CPF12_RS07125	COG0166	Belongs to the GPI family
CPF12_RS07270	COG1472	Belongs to the glycosyl hydrolase 3 family
CPF12_RS07280	COG0346	lactoylglutathione lyase activity
CPF12_RS07330	COG1396	sequence-specific DNA binding
CPF12_RS07335	COG1309	transcriptional regulator
CPF12_RS07350	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CPF12_RS07395	COG1696	Membrane protein involved in D-alanine export
CPF12_RS07400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CPF12_RS07405	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CPF12_RS07450	COG0477	Major facilitator Superfamily
CPF12_RS07465	COG1028	Short-chain dehydrogenase reductase Sdr
CPF12_RS07470	COG0583	DNA-binding transcription factor activity
CPF12_RS07480	COG1011	Hydrolase
CPF12_RS07485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPF12_RS07490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPF12_RS07495	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CPF12_RS07500	COG1120	ATPase activity
CPF12_RS07515	COG2217	Heavy metal translocating P-type atpase
CPF12_RS07520	COG2314	TM2 domain
CPF12_RS07525	COG0475	glutathione-regulated potassium exporter activity
CPF12_RS07535	COG1131	(ABC) transporter
CPF12_RS07540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CPF12_RS07550	COG1619	proteins homologs of microcin C7 resistance protein MccF
CPF12_RS07560	COG1396	sequence-specific DNA binding
CPF12_RS07565	COG3620	sequence-specific DNA binding
CPF12_RS07570	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CPF12_RS07575	COG1647	Serine aminopeptidase, S33
CPF12_RS07580	COG0557	exoribonuclease II activity
CPF12_RS07585	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CPF12_RS07620	COG1846	Transcriptional regulator
CPF12_RS07625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CPF12_RS07630	COG2723	6-phospho-beta-galactosidase activity
CPF12_RS07645	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CPF12_RS07650	COG0561	phosphatase activity
CPF12_RS07670	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CPF12_RS07675	COG2011	ABC-type metal ion transport system permease component
CPF12_RS07680	COG1464	Belongs to the NlpA lipoprotein family
CPF12_RS07685	COG1846	Transcriptional regulator
CPF12_RS07690	COG0534	Mate efflux family protein
CPF12_RS07695	COG0191	fructose-bisphosphate aldolase activity
CPF12_RS07700	COG1597	lipid kinase activity
CPF12_RS07715	COG0500	methyltransferase
CPF12_RS07720	COG3842	ATPase activity
CPF12_RS07730	COG3833	ABC-type maltose transport systems, permease component
CPF12_RS07735	COG1175	transmembrane transport
CPF12_RS07740	COG2182	Extracellular solute-binding protein
CPF12_RS07755	COG1609	Transcriptional regulator
CPF12_RS07770	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
CPF12_RS07780	COG0772	Belongs to the SEDS family
CPF12_RS07785	COG1393	Belongs to the ArsC family
CPF12_RS07790	COG0509	glycine decarboxylation via glycine cleavage system
CPF12_RS07800	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CPF12_RS07805	COG2011	ABC-type metal ion transport system permease component
CPF12_RS07810	COG1464	Belongs to the NlpA lipoprotein family
CPF12_RS07815	COG1464	Belongs to the NlpA lipoprotein family
CPF12_RS07820	COG0396	ATPase activity
CPF12_RS07825	COG0719	Fe-S assembly protein
CPF12_RS07830	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CPF12_RS07835	COG0822	iron-sulfur transferase activity
CPF12_RS07840	COG0719	Fe-S assembly protein
CPF12_RS07850	COG2188	Transcriptional regulator
CPF12_RS07855	COG1263	PTS System
CPF12_RS07855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPF12_RS07855	COG2190	(PTS) system
CPF12_RS07860	COG2723	6-phospho-beta-galactosidase activity
CPF12_RS07885	COG1940	carbohydrate kinase activity
CPF12_RS07905	COG3764	Sortase (surface protein transpeptidase)
CPF12_RS07910	COG2186	Transcriptional regulator
CPF12_RS07915	COG1070	Carbohydrate kinase
CPF12_RS07920	COG2610	gluconate transmembrane transporter activity
CPF12_RS07925	COG1801	Protein of unknown function DUF72
CPF12_RS07930	COG2365	Tyrosine phosphatase family
CPF12_RS07940	COG0737	Belongs to the 5'-nucleotidase family
CPF12_RS07945	COG4470	Protein conserved in bacteria
CPF12_RS07950	COG0647	UMP catabolic process
CPF12_RS07955	COG2807	transmembrane transport
CPF12_RS07980	COG1349	DNA-binding transcription factor activity
CPF12_RS07985	COG1105	Belongs to the carbohydrate kinase PfkB family
CPF12_RS07990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CPF12_RS07990	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPF12_RS07990	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPF12_RS07995	COG0561	phosphatase activity
CPF12_RS08000	COG1253	flavin adenine dinucleotide binding
CPF12_RS08005	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CPF12_RS08010	COG0582	viral genome integration into host DNA
CPF12_RS08060	COG0247	lactate metabolic process
CPF12_RS08065	COG1139	Iron-sulfur cluster binding protein
CPF12_RS08075	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CPF12_RS08080	COG0025	NhaP-type Na H and K H
CPF12_RS08085	COG2910	NAD(P)H-binding
CPF12_RS08090	COG1396	sequence-specific DNA binding
CPF12_RS08090	COG3800	Transcriptional regulator
CPF12_RS08095	COG3842	ATPase activity
CPF12_RS08100	COG1176	ABC-type spermidine putrescine transport system, permease component I
CPF12_RS08120	COG0657	acetylesterase activity
CPF12_RS08130	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CPF12_RS08135	COG1368	sulfuric ester hydrolase activity
CPF12_RS08140	COG0753	catalase activity
CPF12_RS08145	COG3764	Sortase (surface protein transpeptidase)
CPF12_RS08155	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CPF12_RS08165	COG1959	2 iron, 2 sulfur cluster binding
CPF12_RS08170	COG0783	Belongs to the Dps family
CPF12_RS08180	COG0628	permease
CPF12_RS08190	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CPF12_RS08195	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CPF12_RS08210	COG2267	carboxylic ester hydrolase activity
CPF12_RS08220	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CPF12_RS08225	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CPF12_RS08230	COG0582	viral genome integration into host DNA
CPF12_RS08270	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CPF12_RS08290	COG2188	Transcriptional regulator
CPF12_RS08295	COG3830	Belongs to the UPF0237 family
CPF12_RS08300	COG2848	UPF0210 protein
CPF12_RS08315	COG1278	Cold shock
CPF12_RS08320	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CPF12_RS08335	COG2050	protein possibly involved in aromatic compounds catabolism
CPF12_RS08345	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CPF12_RS08355	COG2309	aminopeptidase activity
CPF12_RS08360	COG1597	lipid kinase activity
CPF12_RS08365	COG0716	FMN binding
CPF12_RS08370	COG0024	Methionine aminopeptidase
CPF12_RS08375	COG0024	Methionine aminopeptidase
CPF12_RS08385	COG1295	ribonuclease BN
CPF12_RS08405	COG0006	proline dipeptidase activity
CPF12_RS08410	COG4109	DRTGG domain
CPF12_RS08415	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CPF12_RS08420	COG0708	Exodeoxyribonuclease III
CPF12_RS08425	COG0587	DNA-directed DNA polymerase activity
CPF12_RS08430	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CPF12_RS08450	COG3030	protein affecting phage T7 exclusion by the F plasmid
CPF12_RS08455	COG2707	UPF0756 membrane protein
CPF12_RS08465	COG0372	Belongs to the citrate synthase family
CPF12_RS08470	COG0538	isocitrate dehydrogenase activity
CPF12_RS08475	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CPF12_RS08475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CPF12_RS08480	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CPF12_RS08485	COG0237	dephospho-CoA kinase activity
CPF12_RS08495	COG3611	Membrane attachment protein
CPF12_RS08500	COG1484	DNA-dependent DNA replication
CPF12_RS08505	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CPF12_RS08510	COG2211	Major facilitator Superfamily
CPF12_RS08525	COG2508	Transcriptional regulator
CPF12_RS08530	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CPF12_RS08535	COG1309	transcriptional regulator
CPF12_RS08540	COG0477	Major facilitator Superfamily
CPF12_RS08545	COG0745	RESPONSE REGULATOR receiver
CPF12_RS08550	COG3850	Histidine kinase
CPF12_RS08550	COG5002	protein histidine kinase activity
CPF12_RS08560	COG0577	efflux transmembrane transporter activity
CPF12_RS08565	COG1136	(ABC) transporter
CPF12_RS08570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CPF12_RS08575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CPF12_RS08580	COG2084	Dehydrogenase
CPF12_RS08595	COG0436	Aminotransferase
CPF12_RS08610	COG0517	IMP dehydrogenase activity
CPF12_RS08615	COG0583	DNA-binding transcription factor activity
CPF12_RS08625	COG1473	amidohydrolase
CPF12_RS08630	COG0668	transmembrane transport
CPF12_RS08635	COG2190	(PTS) system
CPF12_RS08640	COG1363	Peptidase, m42
CPF12_RS08660	COG0004	ammonium transporteR
CPF12_RS08665	COG0347	Belongs to the P(II) protein family
CPF12_RS08670	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CPF12_RS08675	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CPF12_RS08680	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CPF12_RS08685	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CPF12_RS08690	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CPF12_RS08695	COG0047	phosphoribosylformylglycinamidine synthase activity
CPF12_RS08700	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CPF12_RS08705	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CPF12_RS08710	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CPF12_RS08715	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CPF12_RS08725	COG0151	Belongs to the GarS family
CPF12_RS08730	COG4496	protein, YerC YecD
CPF12_RS08735	COG0210	DNA helicase
CPF12_RS08745	COG4851	CamS sex pheromone cAM373 precursor
CPF12_RS08750	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CPF12_RS08755	COG0154	amidase activity
CPF12_RS08770	COG5002	protein histidine kinase activity
CPF12_RS08780	COG0318	PFAM AMP-dependent synthetase and ligase
CPF12_RS08790	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CPF12_RS08795	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CPF12_RS08845	COG1086	Polysaccharide biosynthesis protein
CPF12_RS08865	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CPF12_RS08870	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CPF12_RS08880	COG0110	maltose O-acetyltransferase activity
CPF12_RS08890	COG3944	biosynthesis protein
CPF12_RS08895	COG0489	protein tyrosine kinase activity
CPF12_RS08905	COG0110	maltose O-acetyltransferase activity
CPF12_RS08920	COG1956	GAF domain-containing protein
CPF12_RS08925	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CPF12_RS08930	COG1104	cysteine desulfurase activity
CPF12_RS08935	COG0301	tRNA thio-modification
CPF12_RS08940	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CPF12_RS08945	COG0827	DNA restriction-modification system
CPF12_RS08950	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CPF12_RS08955	COG0589	response to stress
CPF12_RS08960	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CPF12_RS08965	COG1136	(ABC) transporter
CPF12_RS08970	COG0577	efflux transmembrane transporter activity
CPF12_RS08975	COG0745	RESPONSE REGULATOR receiver
CPF12_RS08985	COG0371	Dehydrogenase
CPF12_RS08990	COG0583	DNA-binding transcription factor activity
CPF12_RS08995	COG0513	Belongs to the DEAD box helicase family
CPF12_RS09005	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CPF12_RS09010	COG0513	Belongs to the DEAD box helicase family
CPF12_RS09015	COG3402	PFAM membrane-flanked domain
CPF12_RS09030	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CPF12_RS09035	COG2337	Toxic component of a toxin-antitoxin (TA) module
CPF12_RS09045	COG2208	phosphoserine phosphatase activity
CPF12_RS09055	COG2172	sigma factor antagonist activity
CPF12_RS09060	COG1191	sigma factor activity
CPF12_RS09065	COG2183	response to ionizing radiation
CPF12_RS09110	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CPF12_RS09115	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CPF12_RS09120	COG0833	amino acid
CPF12_RS09125	COG0513	Belongs to the DEAD box helicase family
CPF12_RS09140	COG1266	CAAX protease self-immunity
CPF12_RS09155	COG1942	4-Oxalocrotonate Tautomerase
CPF12_RS09160	COG2217	Heavy metal translocating P-type atpase
CPF12_RS09165	COG1902	pentaerythritol trinitrate reductase activity
CPF12_RS09170	COG2271	Major facilitator Superfamily
CPF12_RS09180	COG1331	Highly conserved protein containing a thioredoxin domain
CPF12_RS09205	COG2081	HI0933 family
CPF12_RS09210	COG2384	SAM-dependent methyltransferase
CPF12_RS09215	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CPF12_RS09220	COG1570	exodeoxyribonuclease VII activity
CPF12_RS09230	COG0142	geranyltranstransferase activity
CPF12_RS09235	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CPF12_RS09240	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CPF12_RS09245	COG1438	arginine binding
CPF12_RS09250	COG0497	DNA recombination
CPF12_RS09275	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CPF12_RS09280	COG1420	regulation of RNA biosynthetic process
CPF12_RS09285	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CPF12_RS09295	COG0484	heat shock protein binding
CPF12_RS09305	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CPF12_RS09315	COG1610	YqeY-like protein
CPF12_RS09320	COG1030	water channel activity
CPF12_RS09325	COG4864	UPF0365 protein
CPF12_RS09335	COG1702	phosphate starvation-inducible protein PhoH
CPF12_RS09350	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CPF12_RS09365	COG3853	Toxic anion resistance protein (TelA)
CPF12_RS09380	COG0735	belongs to the Fur family
CPF12_RS09395	COG0019	diaminopimelate decarboxylase activity
CPF12_RS09400	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CPF12_RS09405	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CPF12_RS09410	COG1187	pseudouridine synthase activity
CPF12_RS09415	COG0745	RESPONSE REGULATOR receiver
CPF12_RS09420	COG5002	protein histidine kinase activity
CPF12_RS09425	COG1607	acyl-coa hydrolase
CPF12_RS09430	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CPF12_RS09440	COG2378	regulation of single-species biofilm formation
CPF12_RS09455	COG0514	ATP-dependent DNA helicase (RecQ)
CPF12_RS09465	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CPF12_RS09470	COG0539	negative regulation of cytoplasmic translation
CPF12_RS09480	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CPF12_RS09490	COG0302	gtp cyclohydrolase
CPF12_RS09495	COG0142	geranyltranstransferase activity
CPF12_RS09505	COG0142	geranyltranstransferase activity
CPF12_RS09510	COG0105	UTP biosynthetic process
CPF12_RS09530	COG4401	Chorismate mutase type I
CPF12_RS09535	COG0287	Prephenate dehydrogenase
CPF12_RS09565	COG0457	Tetratricopeptide repeat
CPF12_RS09575	COG2738	Putative neutral zinc metallopeptidase
CPF12_RS09580	COG1131	(ABC) transporter
CPF12_RS09585	COG0842	Transport permease protein
CPF12_RS09600	COG1959	2 iron, 2 sulfur cluster binding
CPF12_RS09605	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CPF12_RS09615	COG1104	cysteine desulfurase activity
CPF12_RS09620	COG0482	sulfurtransferase activity
CPF12_RS09630	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CPF12_RS09640	COG1764	response to oxidative stress
CPF12_RS09645	COG1846	Transcriptional regulator
CPF12_RS09650	COG0778	Nitroreductase
CPF12_RS09655	COG3759	membrane
CPF12_RS09665	COG5002	protein histidine kinase activity
CPF12_RS09665	COG3850	Histidine kinase
CPF12_RS09670	COG0745	RESPONSE REGULATOR receiver
CPF12_RS09675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CPF12_RS09680	COG4472	Bacterial protein of unknown function (DUF965)
CPF12_RS09685	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CPF12_RS09690	COG3906	Belongs to the UPF0473 family
CPF12_RS09695	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CPF12_RS09700	COG0572	uridine kinase
CPF12_RS09705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CPF12_RS09715	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CPF12_RS09720	COG0519	Catalyzes the synthesis of GMP from XMP
CPF12_RS09730	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CPF12_RS09735	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CPF12_RS09740	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CPF12_RS09745	COG1534	Rna-binding protein
CPF12_RS09750	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CPF12_RS09755	COG1713	HD superfamily hydrolase involved in NAD metabolism
CPF12_RS09760	COG0799	negative regulation of ribosome biogenesis
CPF12_RS09765	COG2226	methyltransferase
CPF12_RS09770	COG1555	photosystem II stabilization
CPF12_RS09770	COG1596	polysaccharide export
CPF12_RS09775	COG2131	deaminase
CPF12_RS09780	COG0658	competence protein
CPF12_RS09780	COG2333	competence protein COMEC
CPF12_RS09785	COG1466	dna polymerase III delta subunit
CPF12_RS09790	COG0083	homoserine kinase activity
CPF12_RS09795	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CPF12_RS09800	COG0460	homoserine dehydrogenase
CPF12_RS09815	COG1705	Flagellar rod assembly protein muramidase FlgJ
CPF12_RS09820	COG2195	Cleaves the N-terminal amino acid of tripeptides
CPF12_RS09830	COG0681	Belongs to the peptidase S26 family
CPF12_RS09835	COG0598	Magnesium transport protein CorA
CPF12_RS09845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CPF12_RS09855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CPF12_RS09875	COG5386	Cell surface protein
CPF12_RS09880	COG5386	Cell surface protein
CPF12_RS09895	COG4509	Sortase family
CPF12_RS09900	COG2309	aminopeptidase activity
CPF12_RS09915	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CPF12_RS09915	COG1605	Chorismate mutase
CPF12_RS09940	COG1959	2 iron, 2 sulfur cluster binding
CPF12_RS09945	COG1511	domain protein
CPF12_RS09950	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CPF12_RS09950	COG0392	lysyltransferase activity
CPF12_RS09955	COG0586	Pfam SNARE associated Golgi protein
CPF12_RS09960	COG1090	epimerase
CPF12_RS09965	COG2137	regulation of response to DNA damage stimulus
CPF12_RS09970	COG1988	membrane-bound metal-dependent
CPF12_RS09975	COG1194	a g-specific adenine glycosylase
CPF12_RS09980	COG1028	Short-chain dehydrogenase reductase Sdr
CPF12_RS09985	COG3557	Belongs to the UPF0374 family
CPF12_RS09990	COG0735	belongs to the Fur family
CPF12_RS10215	COG1575	Belongs to the MenA family. Type 1 subfamily
CPF12_RS10220	COG1169	isochorismate synthase
CPF12_RS10225	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CPF12_RS10230	COG0596	Alpha beta hydrolase
CPF12_RS10235	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CPF12_RS10245	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CPF12_RS10250	COG3442	glutamine amidotransferase
CPF12_RS10265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CPF12_RS10280	COG1694	Mazg nucleotide pyrophosphohydrolase
CPF12_RS10285	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CPF12_RS10290	COG0617	tRNA 3'-terminal CCA addition
CPF12_RS10305	COG2390	Transcriptional regulator
CPF12_RS10315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CPF12_RS10320	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CPF12_RS10325	COG1199	ATP-dependent helicase activity
CPF12_RS10325	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CPF12_RS10340	COG0017	Asparaginyl-tRNA synthetase
CPF12_RS10345	COG3935	DnaD domain protein
CPF12_RS10350	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CPF12_RS10355	COG2190	(PTS) system
CPF12_RS10355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPF12_RS10355	COG1263	PTS System
CPF12_RS10360	COG2723	6-phospho-beta-galactosidase activity
CPF12_RS10365	COG3711	transcriptional antiterminator
CPF12_RS10375	COG0577	efflux transmembrane transporter activity
CPF12_RS10385	COG0513	Belongs to the DEAD box helicase family
CPF12_RS10390	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CPF12_RS10395	COG1968	undecaprenyl-diphosphatase activity
CPF12_RS10400	COG0488	(ABC) transporter
CPF12_RS10405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CPF12_RS10405	COG4499	WXG100 protein secretion system (Wss), protein YukC
CPF12_RS10410	COG3331	DNA recombination
CPF12_RS10420	COG4474	Belongs to the UPF0398 family
CPF12_RS10435	COG0116	Belongs to the methyltransferase superfamily
CPF12_RS10440	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CPF12_RS10455	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CPF12_RS10460	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CPF12_RS10495	COG0346	lactoylglutathione lyase activity
CPF12_RS10505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CPF12_RS10510	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CPF12_RS10515	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CPF12_RS10525	COG1940	carbohydrate kinase activity
CPF12_RS10530	COG0328	RNA-DNA hybrid ribonuclease activity
CPF12_RS10540	COG1321	iron dependent repressor
CPF12_RS10550	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CPF12_RS10555	COG0488	(ABC) transporter
CPF12_RS10565	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CPF12_RS10580	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CPF12_RS10590	COG0584	glycerophosphoryl diester phosphodiesterase
CPF12_RS10595	COG1307	EDD domain protein, DegV family
CPF12_RS10600	COG2755	lipolytic protein G-D-S-L family
CPF12_RS10620	COG4479	Belongs to the UPF0346 family
CPF12_RS10625	COG0813	purine-nucleoside phosphorylase activity
CPF12_RS10635	COG0577	efflux transmembrane transporter activity
CPF12_RS10635	COG1136	(ABC) transporter
CPF12_RS10650	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CPF12_RS10655	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CPF12_RS10660	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CPF12_RS10665	COG2205	protein histidine kinase activity
CPF12_RS10670	COG0745	RESPONSE REGULATOR receiver
CPF12_RS10675	COG1131	(ABC) transporter
CPF12_RS10700	COG1937	Protein conserved in bacteria
CPF12_RS10705	COG3409	Peptidoglycan-binding domain 1 protein
CPF12_RS10705	COG0793	Belongs to the peptidase S41A family
CPF12_RS10715	COG2814	Major facilitator Superfamily
CPF12_RS10725	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CPF12_RS10740	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CPF12_RS10745	COG3958	Transketolase
CPF12_RS10755	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
CPF12_RS10760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CPF12_RS10795	COG2814	Major facilitator Superfamily
CPF12_RS10800	COG1309	transcriptional regulator
CPF12_RS10805	COG1929	Belongs to the glycerate kinase type-1 family
CPF12_RS10840	COG3964	amidohydrolase
CPF12_RS10855	COG1454	alcohol dehydrogenase
CPF12_RS10855	COG1012	belongs to the aldehyde dehydrogenase family
CPF12_RS10870	COG2207	Transcriptional regulator
CPF12_RS10875	COG1454	alcohol dehydrogenase
CPF12_RS10875	COG1012	belongs to the aldehyde dehydrogenase family
CPF12_RS10900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CPF12_RS10905	COG2814	Major facilitator Superfamily
CPF12_RS10915	COG0601	transmembrane transport
CPF12_RS10920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CPF12_RS10925	COG4684	Psort location CytoplasmicMembrane, score
CPF12_RS10935	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CPF12_RS10940	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CPF12_RS10945	COG0363	glucosamine-6-phosphate deaminase activity
CPF12_RS10955	COG1942	4-Oxalocrotonate Tautomerase
CPF12_RS10960	COG1349	DNA-binding transcription factor activity
CPF12_RS10965	COG1012	belongs to the aldehyde dehydrogenase family
CPF12_RS10970	COG3718	enzyme involved in inositol metabolism
CPF12_RS10975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CPF12_RS10980	COG3962	Belongs to the TPP enzyme family
CPF12_RS10990	COG2814	Major facilitator Superfamily
CPF12_RS10995	COG0673	inositol 2-dehydrogenase activity
CPF12_RS11000	COG1082	Xylose isomerase domain protein TIM barrel
CPF12_RS11005	COG1082	Xylose isomerase domain protein TIM barrel
CPF12_RS11010	COG0191	fructose-bisphosphate aldolase activity
CPF12_RS11015	COG0456	acetyltransferase
CPF12_RS11020	COG1388	LysM domain
CPF12_RS11020	COG3584	3D domain protein
CPF12_RS11025	COG0833	amino acid
CPF12_RS11035	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CPF12_RS11040	COG0028	Belongs to the TPP enzyme family
CPF12_RS11045	COG3527	Alpha-acetolactate decarboxylase
CPF12_RS11050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CPF12_RS11060	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CPF12_RS11065	COG1234	tRNA 3'-trailer cleavage
CPF12_RS11070	COG0300	oxidoreductase activity
CPF12_RS11075	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CPF12_RS11085	COG0752	glycyl-tRNA synthetase alpha subunit
CPF12_RS11100	COG0358	DNA primase activity
CPF12_RS11100	COG0305	Participates in initiation and elongation during chromosome replication
CPF12_RS11105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CPF12_RS11125	COG0577	efflux transmembrane transporter activity
CPF12_RS11125	COG1136	(ABC) transporter
CPF12_RS11130	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CPF12_RS11140	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CPF12_RS11145	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CPF12_RS11150	COG0367	asparagine synthase
CPF12_RS11160	COG1064	alcohol dehydrogenase
CPF12_RS11165	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CPF12_RS11210	COG0495	leucyl-tRNA aminoacylation
CPF12_RS11220	COG1136	(ABC) transporter
CPF12_RS11220	COG0577	efflux transmembrane transporter activity
CPF12_RS11225	COG1760	l-serine dehydratase
CPF12_RS11230	COG1760	l-serine dehydratase
CPF12_RS11235	COG1522	sequence-specific DNA binding
CPF12_RS11240	COG2244	polysaccharide biosynthetic process
CPF12_RS11245	COG1187	pseudouridine synthase activity
CPF12_RS11250	COG0735	belongs to the Fur family
CPF12_RS11270	COG1522	sequence-specific DNA binding
CPF12_RS11275	COG1609	Transcriptional regulator
CPF12_RS11285	COG1733	regulation of RNA biosynthetic process
CPF12_RS11290	COG2910	NAD(P)H-binding
CPF12_RS11295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CPF12_RS11305	COG0564	pseudouridine synthase activity
CPF12_RS11315	COG2233	PERMEase
CPF12_RS11325	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CPF12_RS11335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CPF12_RS11345	COG0167	dihydroorotate dehydrogenase activity
CPF12_RS11350	COG0284	orotidine-5'-phosphate decarboxylase activity
CPF12_RS11370	COG1136	(ABC) transporter
CPF12_RS11405	COG0477	Major facilitator Superfamily
CPF12_RS11420	COG1028	Short-chain dehydrogenase reductase Sdr
CPF12_RS11425	COG0697	spore germination
CPF12_RS11430	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CPF12_RS11435	COG0194	GDP metabolic process
CPF12_RS11445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CPF12_RS11450	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CPF12_RS11455	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CPF12_RS11460	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CPF12_RS11460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CPF12_RS11470	COG0515	serine threonine protein kinase
CPF12_RS11470	COG2815	serine threonine protein kinase
CPF12_RS11475	COG1162	GTPase activity
CPF12_RS11480	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CPF12_RS11485	COG1564	THIamine pyrophosphokinase
CPF12_RS11490	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CPF12_RS11495	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CPF12_RS11510	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CPF12_RS11520	COG0416	fatty acid biosynthetic process
CPF12_RS11525	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CPF12_RS11530	COG1028	Short-chain dehydrogenase reductase Sdr
CPF12_RS11535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CPF12_RS11545	COG1196	nuclear chromosome segregation
CPF12_RS11550	COG0552	protein localization to endoplasmic reticulum
CPF12_RS11555	COG4555	ABC transporter
CPF12_RS11590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CPF12_RS11595	COG0583	DNA-binding transcription factor activity
CPF12_RS11605	COG0667	Aldo Keto reductase
CPF12_RS11615	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CPF12_RS11620	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CPF12_RS11625	COG0228	four-way junction DNA binding
CPF12_RS11635	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CPF12_RS11640	COG0336	Belongs to the RNA methyltransferase TrmD family
CPF12_RS11645	COG0335	large ribosomal subunit rRNA binding
CPF12_RS11660	COG3279	Response regulator of the LytR AlgR family
CPF12_RS11710	COG1690	Belongs to the RtcB family
CPF12_RS11750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CPF12_RS11760	COG0561	phosphatase activity
CPF12_RS11770	COG0583	DNA-binding transcription factor activity
CPF12_RS11795	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CPF12_RS11800	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CPF12_RS11805	COG0758	DNA mediated transformation
CPF12_RS11810	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CPF12_RS11815	COG4974	Belongs to the 'phage' integrase family
CPF12_RS11820	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CPF12_RS11825	COG0824	Thioesterase
CPF12_RS11835	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CPF12_RS11840	COG0187	DNA topoisomerase II activity
CPF12_RS11845	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CPF12_RS11850	COG0584	glycerophosphoryl diester phosphodiesterase
CPF12_RS11855	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CPF12_RS11860	COG0789	Transcriptional regulator
CPF12_RS11865	COG0174	glutamine synthetase
CPF12_RS11890	COG1692	metallophosphoesterase
CPF12_RS11895	COG4550	Control of competence regulator ComK, YlbF/YmcA
CPF12_RS11900	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CPF12_RS11910	COG0745	RESPONSE REGULATOR receiver
CPF12_RS11920	COG1136	(ABC) transporter
CPF12_RS11925	COG1136	(ABC) transporter
CPF12_RS11950	COG1131	(ABC) transporter
CPF12_RS11960	COG1131	(ABC) transporter
CPF12_RS11975	COG3279	Response regulator of the LytR AlgR family
CPF12_RS11985	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CPF12_RS11995	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CPF12_RS12000	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CPF12_RS12005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CPF12_RS12010	COG1335	isochorismatase
CPF12_RS12020	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CPF12_RS12065	COG1113	amino acid transport
CPF12_RS12075	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CPF12_RS12085	COG0765	amino acid transport
CPF12_RS12090	COG0765	amino acid transport
CPF12_RS12095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CPF12_RS12100	COG1126	abc transporter atp-binding protein
CPF12_RS12105	COG0488	(ABC) transporter
CPF12_RS12110	COG0519	Catalyzes the synthesis of GMP from XMP
CPF12_RS12115	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CPF12_RS12120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CPF12_RS12125	COG0527	aspartate kinase activity
CPF12_RS12130	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CPF12_RS12135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CPF12_RS12140	COG0697	spore germination
CPF12_RS12145	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CPF12_RS12155	COG1185	polyribonucleotide nucleotidyltransferase activity
CPF12_RS12160	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CPF12_RS12165	COG0196	riboflavin kinase activity
CPF12_RS12175	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CPF12_RS12180	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CPF12_RS12195	COG0195	Participates in both transcription termination and antitermination
CPF12_RS12200	COG0779	Required for maturation of 30S ribosomal subunits
CPF12_RS12225	COG2176	DNA-directed DNA polymerase activity
CPF12_RS12235	COG0488	(ABC) transporter
CPF12_RS12255	COG1695	Transcriptional regulator
CPF12_RS12275	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CPF12_RS12280	COG1518	maintenance of DNA repeat elements
CPF12_RS12285	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
CPF12_RS12310	COG0750	zinc metalloprotease
CPF12_RS12315	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CPF12_RS12320	COG4589	Belongs to the CDS family
CPF12_RS12325	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CPF12_RS12330	COG0233	cytoplasmic translational termination
CPF12_RS12335	COG0528	UMP kinase activity
CPF12_RS12340	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CPF12_RS12345	COG0052	Belongs to the universal ribosomal protein uS2 family
CPF12_RS12350	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CPF12_RS12360	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CPF12_RS12370	COG0419	ATPase involved in DNA repair
CPF12_RS12375	COG0420	3'-5' exonuclease activity
CPF12_RS12385	COG0204	Acyl-transferase
CPF12_RS12395	COG1704	LemA family
CPF12_RS12405	COG4846	Membrane protein involved in cytochrome C biogenesis
CPF12_RS12410	COG1132	(ABC) transporter
CPF12_RS12415	COG1132	(ABC) transporter
CPF12_RS12425	COG3763	UPF0154 protein
CPF12_RS12430	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CPF12_RS12445	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CPF12_RS12460	COG0113	porphobilinogen synthase activity
CPF12_RS12465	COG0181	hydroxymethylbilane synthase activity
CPF12_RS12470	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CPF12_RS12475	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III